CN107812039A - A kind of beautiful millettia root Chinese medicine composition with function of reinforcing the kidney to strengthen the bone and preparation method thereof - Google Patents
A kind of beautiful millettia root Chinese medicine composition with function of reinforcing the kidney to strengthen the bone and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of beautiful millettia root Chinese medicine composition with function of reinforcing the kidney to strengthen the bone and preparation method thereof.Chinese medicine composition of the present invention is mainly made up of beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root, root of kudzu vine etc., prescription is rigorous, the few power of medicine is special, all medicines share can play the integrally-regulated advantage of Chinese medicine compound prescription, the effect of with kidney tonifying, strong muscles and bones, there is the effect of good to osteoporosis, soreness of waist and knee joint, eak after being ill, the aching and limp symptom such as powerless.
Description
Technical field
Have the present invention relates to one kind and reinforce the kidney to strengthen the bone function, can the beautiful millettia root Chinese medicine composition of anti-osteoporosis and its specific
Preparation method.
Background technology
Osteoporosis (OP) be one kind characterized by Low BMD and bone tissue Microstructure Fracture, cause sclerotin fragility increase and
It is easy to the systemic bone metabolic disease of fracture.In most osteoporosises, the reduction of bone tissue increases mainly due to bone absorption
It is more caused.With ostalgia and lumbago, hunchback, easily hair fracture for three big cardinal symptoms, with becoming clear day by day for aging population, bone
The illness rate of matter osteoporosis increasingly raises, therefore how anti-curing osteoporosis has become the focus that the world of medicine is studied in recent years.
At present, the method for western medicine osteoporosis mainly has anti-absorption therapy, anabolism therapy and promotes bone mineralising method, but west
Medicine treatment is undesirable there is late result to varying degrees, and side effect is big, the shortcomings of drug price costliness, and treatment by Chinese herbs
Positive effect and Small side effects, therefore in recent years, treatment by Chinese herbs osteoporosis increasingly attracts people's attention.
The general extracting method of Chinese medicine be medicine materical crude slice directly decoct or coarse crushing after solvent extraction, these extracting methods are to equipment
It is required that low, but longer the time required to extracting, and composition in cell wall is more difficult extracts, and causes effective component extraction rate low, and
Medicinal material can then improve the above situation after ultramicro grinding.Ultramicro grinding is to develop very fast one in the world in recent years
New technology, compared with general crush, particle is smaller, and particle diameter can reach 0.1~10 μm.Chinese medicine is after ultramicro grinding, granularity
Uniformly fine and closely woven, cell membrane crushes, and cell-wall breaking ratio can reach more than 95%, is advantageous to the dissolution of active ingredient in medicinal material, makes medicine
The recovery rate of material active ingredient greatly increases, while can shorten extraction time, reduces using and wasting for solvent.
The present invention is to provide a kind of beautiful millettia root Chinese medicine composition with function of reinforcing the kidney to strengthen the bone and preparation method thereof.At present
It can effectively alleviate or treat the medicine or health food and few of osteoporosis, and the present composition is in traditional Chinese medical theory
Under guidance, scientific formula, the pain of patient can be relieved, the quality of life of the elderly is improved, is worth application.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition with function of reinforcing the kidney to strengthen the bone and preparation method thereof, the group
Compound is made up of the bulk drug of following parts by weight：
Beautiful millettia root 10-30 parts, bark of eucommia 10-30 parts, barrenwort 5-25 parts, Semen Cuscutae 5-25 parts, red sage root 5-25 parts, root of kudzu vine 5-
15 parts, FOS 5-10 parts, calcium gluconate 0.05-2.0 parts.
The weight part ratio of the bulk drug of the present composition is preferably：
10 parts of beautiful millettia root, 10 parts of the bark of eucommia, 5 parts of barrenwort, 5 parts of Semen Cuscutae, 5 parts of the red sage root, 5 parts of the root of kudzu vine, 5 parts of FOS,
0.05 part of calcium gluconate.
The weight part ratio of the bulk drug of the present composition is also preferably：
20 parts of beautiful millettia root, 20 parts of the bark of eucommia, 15 parts of barrenwort, 15 parts of Semen Cuscutae, 15 parts of the red sage root, 10 parts of the root of kudzu vine, FOS 7
Part, 1.0 parts of calcium gluconate.
The weight part ratio of the bulk drug of the present composition is also preferably：
30 parts of beautiful millettia root, 30 parts of the bark of eucommia, 25 parts of barrenwort, 25 parts of Semen Cuscutae, 25 parts of the red sage root, 15 parts of the root of kudzu vine, FOS
10 parts, 2.0 parts of calcium gluconate.
Chinese medicine composition of the present invention is mainly made up of following steps：
(1) beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root and the root of kudzu vine are cleaned, dried, by required bulk drug weight ratio
Example weighs；
(2) load weighted Chinese medicine is put into micronizer and crushed, collect micro mist (crossing 300 mesh), it is standby；
(3) micro mist obtained by step (2) is put into Multifunctional Chinese medicine extractor, adds the 8-10 times of water measured, heating extraction
1-3 times, each 0.5-2h, filtering, filtrate is collected, merged；
(4) filtrate heating is condensed into thick medicinal extract, be dried under reduced pressure blocking (moisture≤5%), crushed, collect fine powder；
(5) fine powder obtained by step (4) is well mixed with required FOS, calcium gluconate, produced.
Wherein, the formulation of the present composition is oral powder, tablet, capsule or granule.
Modern Chinese medicine is from dialectical angle analysis osteoporosis, it is believed that this sick cause of disease, the interpretation of the cause, onset and process of an illness are summarized as kidney deficiency, insufficiency of the spleen and blood
The stasis of blood, thus clinically the treatment to osteoporosis should with warming and invigorating kidney Yang, strengthen muscles and bones, based on replenishing essence life marrow, and supported with QI invigorating
Blood, functions dispelling wind and clearing away cold, removing dampness, remove obstruction in channels to relieve pain based on.
Beautiful millettia root, it is the dry root of pulse family Papillionoideae Millettia plant beautiful millettia, also known as beautiful millettia root, blood
Rattan, energetically Tianniudali, potato etc., sweet mild-natured, the active effect of the moistening lung of tool qi-restoratives, strengthening tendons.Beautiful millettia root is extensive in Guangdong and Guangxi Provinces area
As Baoshang raw material, herbal cuisine, medicinal liquor etc. are made, it is notable to mend waist kidney, strengthening the bones and muscles effect.Clinically lumbar muscle strain, rheumatic are closed
The chronic diseases and stable damage, seminal emission, leukorrhea etc. such as section inflammation, pulmonary tuberculosis, chronic bronchitis have certain curative effect.
The bark of eucommia, it is the dry bark that the Eucommiaceae bark of eucommia belongs to perennial deciduous tree gutta-percha tree, there is the strong kidney of tonifying liver, strengthening tendons to be good for
The effect of bone, its chemical composition contained are mainly lignanoids, iridoids, flavonoids, Phenylpropanoid Glycosides class, terpene and polysaccharide
Class etc..Modern pharmacological research proves that the bark of eucommia has lowering blood pressure and blood fat, hypoglycemic, antitumor, anti-inflammatory, anti-oxidant, liver protection shield
Kidney, anti-osteoporosis etc. act on.Its anti-osteoporosis mechanism is stimulated osteoblastic proliferation, differentiation and maturation and suppresses osteoclastic thin
Intracellular growth；Promote the propagation of medulla mesenchyma cell；Promote Mineralization, increase bone density, improve bone trabecula microbody structure.
Barrenwort, it is warm-natured, it is sweet, pungent, it is traditional tonifying kidney and strengthening yang using kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling as primary efficacy
Class Chinese medicine.Its principle active component is polysaccharide and flavones, has extensive pharmacological action, can promote hematopoiesis function, suppresses cardiac muscle
Convergent force, improve cerebral hypoxia ischemia, improve immunologic function and regulation Bone m etabolism etc..The main mechanism of its anti-osteoporosis disease effect
It is the activity for suppressing osteoclast, promotes function of osteoblast, body Bone m etabolism is in bon e formation just flat more than bone information
Weighing apparatus state, so as to suppress bone loss, and reach the purpose for treating and preventing osteoporosis.
Semen Cuscutae, it is annual parasitics draft, Convolvulaceae, the mature seed of platymiscium, also known as dragon, spins
Son, it is pungent, sweet, put down, Return liver, kidney, the spleen channel, there is kidney-supplementing liver-boosting, astringent sperm contracting urine, antiabortive, improving eyesight, antidiarrheal and other effects.It is main to contain Huang
The chemical compositions such as ketone, polysaccharide, alkaloids, volatile oil and amino acids, to reproductive system, immune system, liver, blood
Glucemia fat, bone and cartilage have certain adjustment effect.Cell experiment has proven to thin with extracting solution of south dodder seed in vitro culture skeletonization
Born of the same parents, the matrix calcium of Gegenbaur's cell can be improved, promote propagation and improve the activity of alkaline phosphatase, while suppress the life of osteoclast
Deposit rate and can induce its apoptosis, play a part of suppressing osteoporosis.
The red sage root, cold nature is bitter, pungent, and there is promoting blood circulation and removing blood stasis, cool blood to disappear carbuncle, relieving restlessness to calm the nerves and other effects, be that tcm clinical practice passes
The blood-activating and menstruation-regulating medicinal of system.The red sage root is appeared in frequently as ancillary drug in the prescription for the treatment of osteoporosis, according to theory of traditional Chinese medical science master
The effect of applying its promoting blood circulation and removing blood stasis, carry out promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain on the basis of kidney and spleen invigorating, can preferably treat by
The hemostasis caused by kidney deficiency, while alleviate because of bone pain symptom caused by osteoporosis.Its composition is mainly fat-soluble pellet
Join ketone and water miscible danshinolic acid class, modern pharmacology test result indicates that, the red sage root can promote osteocyte like cell ripe, add
Fast union, and increase key weight.
The root of kudzu vine, it is the dry root of legume pueraria lobata or Pachyrhizua angulatus, first recorded in《Sheng Nong's herbal classic》, it is sweet, pungent, it is cool, there is expelling pathogenic factors from muscles and skin
Bring down a fever, promoting eruption, promote the production of body fluid to quench thirst, the work(of Shengyang Zhixie.Contain a kind of osajin composition, referred to as Puerarin in the root of kudzu vine, be a kind of
Phytoestrogen, alkaline phosphatase (ALT) can be stimulated active, MAPK (MAPK) level be improved, to broken
Osteoclastic bone resorption function has direct repression, prevents bone density and bone mineral content from reducing, there is certain anti-sclerotin to dredge
The effect of pine.
FOS is a kind of typical prebiotics, has excellent physicochemical property and physiological function, can breed in enteron aisle
Bifidobacterium, improve gut flora；Relax bowel；The content of the lipid and cholesterol in blood is reduced, improves lipid-metabolism；
Suppress the generation of corrupt substance in enteron aisle, promote the absorption of the mineral elements such as calcium and magnesium；Strengthen immunity of organisms, cancer wind is suffered from reduction
Danger, is widely applied in the industries such as food, health products, feed.
Calcium gluconate, be odorless, tasteless, white crystal or graininess powder, be mainly used as the Creta Preparata of food with
Nutritional agents and intercalating agent etc..Low blood Ca can be prevented2+, control tetany disease breaking-out, it can also be used to nettle rash, acute eczema,
Antipruritic, the balance of calcium ion in holding body of dermatitis etc..
The present composition is mainly made up of beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root, root of kudzu vine etc., is in the traditional Chinese medical science
On the basis of medicine traditional theory, it is formulated with reference to the theory of medication experience among the people and science.Prescription is rigorous, the few power of medicine is special, all
Medicine shares the integrally-regulated advantage that can play Chinese medicine compound prescription, has the effect of kidney tonifying, strong muscles and bones, to osteoporosis, waist and knee acid
Bitterly, eak after being ill, the aching and limp symptom such as powerless have the effect of good.
Embodiment
With reference to embodiment, technical scheme is further illustrated.
Raw material used in following examples is purchased from the peaceful medicinal material market in Guangzhou.
Embodiment 1
Prescription：
10 parts of beautiful millettia root, 10 parts of the bark of eucommia, 5 parts of barrenwort, 5 parts of Semen Cuscutae, 5 parts of the red sage root, 5 parts of the root of kudzu vine, 5 parts of FOS,
0.05 part of calcium gluconate.
Preparation method：
(1) beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root and the root of kudzu vine are cleaned, dried, by required bulk drug weight ratio
Example weighs；
(2) load weighted Chinese medicine is put into micronizer and crushed, collect micro mist (crossing 300 mesh), it is standby；
(3) micro mist obtained by step (2) is put into Multifunctional Chinese medicine extractor, adds the 8-10 times of water measured, heating extraction
1-3 times, each 0.5-2h, filtering, filtrate is collected, merged；
(4) filtrate heating is condensed into thick medicinal extract, be dried under reduced pressure blocking (moisture≤5%), crushed, collect fine powder；
(5) fine powder obtained by step (4) is well mixed with required FOS, calcium gluconate, produced.
Embodiment 2
Prescription：
20 parts of beautiful millettia root, 20 parts of the bark of eucommia, 15 parts of barrenwort, 15 parts of Semen Cuscutae, 15 parts of the red sage root, 10 parts of the root of kudzu vine, FOS 7
Part, 1.0 parts of calcium gluconate.
Preparation method：
(1) beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root and the root of kudzu vine are cleaned, dried, by required bulk drug weight ratio
Example weighs；
(2) load weighted Chinese medicine is put into micronizer and crushed, collect micro mist (crossing 300 mesh), it is standby；
(3) micro mist obtained by step (2) is put into Multifunctional Chinese medicine extractor, adds the 8-10 times of water measured, heating extraction
1-3 times, each 0.5-2h, filtering, filtrate is collected, merged；
(4) filtrate heating is condensed into thick medicinal extract, be dried under reduced pressure blocking (moisture≤5%), crushed, collect fine powder；
(5) fine powder obtained by step (4) is well mixed with required FOS, calcium gluconate, produced.
Embodiment 3
Prescription：
30 parts of beautiful millettia root, 30 parts of the bark of eucommia, 25 parts of barrenwort, 25 parts of Semen Cuscutae, 25 parts of the red sage root, 15 parts of the root of kudzu vine, FOS
10 parts, 2.0 parts of calcium gluconate.
Preparation method：
(1) beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root and the root of kudzu vine are cleaned, dried, by required bulk drug weight ratio
Example weighs；
(2) load weighted Chinese medicine is put into micronizer and crushed, collect micro mist (crossing 300 mesh), it is standby；
(3) micro mist obtained by step (2) is put into Multifunctional Chinese medicine extractor, adds the 8-10 times of water measured, heating extraction
1-3 times, each 0.5-2h, filtering, filtrate is collected, merged；
(4) filtrate heating is condensed into thick medicinal extract, be dried under reduced pressure blocking (moisture≤5%), crushed, collect fine powder；
(5) fine powder obtained by step (4) is well mixed with required FOS, calcium gluconate, produced.
In order to confirm that Chinese medicine composition of the present invention has the effect of reinforcing the kidney to strengthen the bone, with the micro mist as made from the method for embodiment 1,
Experimental study is carried out：
1 experiment material
1.1 experimental animal：Using 6 months aged Wistar rats 60, female, SPF levels, body weight (300 ± 20) g, by Guangdong
Experimental Animal Center is saved to provide.
1.2 experimental drug：Test sample：The solution of dosage needed for gavage is made in beautiful millettia root Chinese medicine composition micro mist, and valeric acid is female
Glycol (Zhejiang Province XianJu Pharmacy stock Co., Ltd), quadracycline (Shanghai Liu Shi Pharmaceutical Technology Co., Ltd), 10% hydration
Chloral solution, penicillin (800,000 U/ branch, Huabei Pharmaceutic Co., Ltd).
2 experimental methods
All Animal adaptabilities feed 10d before the experiment of 2.1 animal packets, by 60 rats according to random digits table point
For two groups：One group is blank control group 10, and another group is modeling group 50.5 groups are randomly divided into again after modeling success, i.e.,
Model control group 10, composition high dose group 10 of reinforcing the kidney to strengthen the bone, composition middle dose group of reinforcing the kidney to strengthen the bone 10, reinforces the kidney to strengthen the bone
Composition low dose group 10, estrogen group 10.
After 2.2 50 rats of animal model modeling group are with 10% chloraldurate solution 3mL/kg intraperitoneal injection of anesthesia, bow
Clinostatism is fixed on experiment operating table, is lost hair or feathers in back surgery incision, after Iodophor partly sterilised skin, is cut through back center
After mouth approach for resection bilateral ovaries, successively close, sew up the incision.After alcohol disinfecting, postoperative that 3d gluteal muscle penicillin is used in conjunction is pre-
Anti- infection, postoperative continuation routine feeding 3 months.Continuous 3d does vaginal smear within postoperative 2nd day, it turned out that ovary has been cut off
Entirely, osteoporosis models in ovariectomized rats is successfully established.
2.3 animals administration modeling success after 4d start, into the gavage stage, composition low dose group of reinforcing the kidney to strengthen the bone with into
People's routine dose is converted into 1 times of dose,equivalent by people's mouse Shape Coefficient, and middle dose group is with 2 times of calculating, and high dose group is in terms of 4 times
Calculate, gavage liquid dosages are calculated with 1mL/100g gauge, concentrate is made in respective sets gavage；It is female that estrogen group gives valeric acid
Glycol presses daily 90 μ g/kg gavages by people mouse dose,equivalent.Normal group and model control group with etc. dosage physiological saline fill
Stomach.All rats 15d before execution carries out the 1st fluorescence labeling, the daily 30mg/kg of quadracycline, is injected intraperitoneally, continuously
2d.3d before execution rat, carries out the 2nd mark, and method is same as above.Each drug dose is carried out according to people's mouse body surface area scaling method
Conversion.
3 Indexs measures
3.1 bone densities (BMD) measure Dual X-ray BMD measuring instruments measure rat femur and lumbar vertebrae BMD.
3.2 bone biomechanicals determine femur three point bending test：Femur bone biomechanical is determined using three-point bending method, surveyed
Timing span 20mm, middle tibia is pushed with 10mm/min loading speeds, until femur is broken.By Experiments of Machanics test machine
Software records load-deflection curve and analyze data are carried, records load-displacement curves, modulus of elasticity, maximum load is calculated, bends
Take the bone biomechanical index such as intensity.
Rat femur is put into baking box by 3.3 bone mineral salt contents measure, 105 DEG C dry to constant weight after to weigh be dry weight, it is roasting
Sample after dry is put into 650 DEG C of ashing 36h of ashing furnace, and it is Ash weight to take out weighing, and mineral content is Ash weight and dry weight
The ratio between.
3.4 statistical method application SPSS17.0 statistical softwares carry out data processing, and measurement data is with mean ± standard deviationRepresent, multigroup is compared using one-way analysis of variance, is compared between group and is examined using q, and P ＜ 0.05 are that difference has statistics
Learn meaning.
4 experimental results
4.1 each group rats with left femur BMD values and bone mineral content comparision contents are compared with blank control group, model control group stock
Bone BMD values are decreased obviously, and illustrate that rat BMD and bone mineral content content are decreased obviously after removing ovary, difference is statistically significant
(P ＜ 0.05).Compared with model control group, the BMD and bone mineral content of high dose group and estrogen group contain in composition of reinforcing the kidney to strengthen the bone
Amount is significantly improved, composition high dose group of reinforcing the kidney to strengthen the bone and estrogen group no significant difference (P ＞ 0.05).It is shown in Table
1。
The each group rats with left femur BMD values of table 1 and bone mineral content comparision contents
Biomechanical properties index determining results contrast model control group and blank control group phase on the right side of 4.2 each group rats
Than the modulus of elasticity of rat femur, maximum load, yield strength decline, and difference is statistically significant (P ＜ 0.05).This explanation
After rat excision ovary, biomechanical property has decline.High dose group in composition of reinforcing the kidney to strengthen the bone is compared with model control group,
Every biomechanical has different degrees of improvement, and difference is statistically significant (P ＜ 0.05), compared with blank control group
No significant difference (P ＞ 0.05).This explanation rat is after ovary is cut off with the continuous reduction of sclerotin content, bone biology
Mechanical properties decrease；It after being treated using composition of reinforcing the kidney to strengthen the bone, can be improved its bone biomechanical property.It is shown in Table 2.
Biomechanical properties index determining results contrast on the right side of each group rat of table 2
5 experiment conclusions
Test result indicates that the bone density of ovariectomized rats, bone mineral content content, modulus of elasticity, maximum load and surrender
After intensity is decreased obviously, but gavage gives composition of reinforcing the kidney to strengthen the bone, These parameters have risen.Give middle high dose group
The group of compound, even there was no significant difference with blank control group for its index, illustrates to reinforce the kidney to strengthen the bone composition to a certain extent
Ovariectomized female rats bone amount can be prevented to lose, its mechanism is with reducing bone degree of switching, and promoting bone growing enters while suppressing bone information
And maintain bone amount relevant, there is good anti-osteoporosis.
Claims (7)
1. a kind of beautiful millettia root Chinese medicine composition with function of reinforcing the kidney to strengthen the bone and preparation method thereof, it is characterised in that by following weight
The bulk drug of part is made：Beautiful millettia root 10-30 parts, bark of eucommia 10-30 parts, barrenwort 5-25 parts, Semen Cuscutae 5-25 parts, red sage root 5-25
Part, root of kudzu vine 5-15 parts, FOS 5-10 parts, calcium gluconate 0.05-2.0 parts.
2. application according to claim 1, it is characterised in that be made up of the bulk drug of following parts by weight：10 parts of beautiful millettia root,
10 parts of the bark of eucommia, 5 parts of barrenwort, 5 parts of Semen Cuscutae, 5 parts of the red sage root, 5 parts of the root of kudzu vine, 5 parts of FOS, 0.05 part of calcium gluconate.
3. application according to claim 1, it is characterised in that be made up of the bulk drug of following parts by weight：20 parts of beautiful millettia root,
20 parts of the bark of eucommia, 15 parts of barrenwort, 15 parts of Semen Cuscutae, 15 parts of the red sage root, 10 parts of the root of kudzu vine, 7 parts of FOS, 1.0 parts of calcium gluconate.
4. application according to claim 1, it is characterised in that be made up of the bulk drug of following parts by weight：30 parts of beautiful millettia root,
30 parts of the bark of eucommia, 25 parts of barrenwort, 25 parts of Semen Cuscutae, 25 parts of the red sage root, 15 parts of the root of kudzu vine, 10 parts of FOS, calcium gluconate 2.0
Part.
5. according to the application described in claim any one of 1-4, it is characterised in that the Chinese medicine composition comprises the steps of：
(1) beautiful millettia root, the bark of eucommia, barrenwort, Semen Cuscutae, the red sage root and the root of kudzu vine are cleaned, dries, claim by required bulk drug part by weight
Take；
(2) load weighted Chinese medicine is put into micronizer and crushed, collect micro mist (crossing 300 mesh), it is standby；
(3) micro mist obtained by step (2) is put into Multifunctional Chinese medicine extractor, adds the 8-10 times of water measured, heating extraction 1-3
It is secondary, each 0.5-2h, filtering, filtrate is collected, merged；
(4) filtrate heating is condensed into thick medicinal extract, be dried under reduced pressure blocking (moisture≤5%), crushed, collect fine powder；
(5) fine powder obtained by step (4) is well mixed with required FOS, calcium gluconate, produced.
6. composition according to claim 5, it is characterised in that：The formulation of composition is oral powder or preparation.
7. composition according to claim 6, it is characterised in that：Oral formulations are selected from tablet, capsule, granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108094808A (en) * | 2017-11-30 | 2018-06-01 | 佛山科学技术学院 | A kind of beautiful millettia root instant solid drink and preparation method thereof |
| CN110448590A (en) * | 2019-09-23 | 2019-11-15 | 玉林师范学院 | A kind of Millettia speciosa Champ.extract with enhancing sexual function effect and preparation method thereof and purposes |
-
2017
- 2017-10-23 CN CN201711060487.2A patent/CN107812039A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108094808A (en) * | 2017-11-30 | 2018-06-01 | 佛山科学技术学院 | A kind of beautiful millettia root instant solid drink and preparation method thereof |
| CN110448590A (en) * | 2019-09-23 | 2019-11-15 | 玉林师范学院 | A kind of Millettia speciosa Champ.extract with enhancing sexual function effect and preparation method thereof and purposes |
| CN110448590B (en) * | 2019-09-23 | 2023-08-25 | 玉林师范学院 | Oriental millettia root extract with sexual function enhancing effect, and preparation method and application thereof |
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Application publication date: 20180320 |