CN102614250A - Natural medicine composition capable of increasing bone density and preventing and treating osteoporosis - Google Patents
Natural medicine composition capable of increasing bone density and preventing and treating osteoporosis Download PDFInfo
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- CN102614250A CN102614250A CN2012101005643A CN201210100564A CN102614250A CN 102614250 A CN102614250 A CN 102614250A CN 2012101005643 A CN2012101005643 A CN 2012101005643A CN 201210100564 A CN201210100564 A CN 201210100564A CN 102614250 A CN102614250 A CN 102614250A
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Abstract
The invention relates to a natural medicine composition capable of increasing the bone density and preventing and treating the osteoporosis. The natural medicine composition is characterized by comprising antler, kudzu root, epimedium, malaytea scurfpea, and pearl powder. The synergistic action of the above components is used to produce an oral preparation, such as hard capsules, soft capsules, tablets, granules, powders, pills, tea bags, medicinal wine, and oral liquid. The composition can be used in the Chinese patent medicine or the health care food capable of preventing and treating the osteoporosis.
Description
Technical field
The invention relates to a kind of natural drug composition of preventing and treating the osteoporosis function that has, the invention belongs to medicine and field of food.
Background technology
Osteoporosis (ostcoporosis, be called for short 0P) be with unit volume internal skeleton amount reduce, the micro structure of bone deteriorates to characteristic so that the fragility of bone increases and a kind of whole body skeletal diseases of the systemic multi-pathogenesis that fracture risk increases.Clinical manifestation lumbago and backache, physical abnormality, fracture etc.The fracture that is caused by osteoporosis accounts for about 50% of the total incidence rate of fracture, and senile fracture, particularly hip fracture are the most serious on pathogenic degree and mortality rate.And common lumbar and back pain also has greatly and is caused by osteoporosis in the women.And when osteoporosis took place the human spine, vertebral body made health shorten under body weight pressure or the formation hunchback because of loose fragile, causes serious consequence.Therefore, exploitation treatment medicine for treating osteoporosis broad market prospect can be brought good social benefit and economic benefit.The theoretical system of its pathogenesis Chinese and western medicine is different, but main theory is common.The traditional Chinese medical science is thought " kidney governing bones ", and suffering from a deficiency of the kidney is the basic pathogenesis of osteoporosis, and insufficiency of the spleen, blood stasis also exerts an influence to it.And doctor trained in Western medicine is thought with age, and gonadal hormone reduces or generation physiological degeneration in the body, causes bone metabolism disturbance; Balance between osteoblast and osteoclast effect is broken; Bone resorption causes that greater than bone formation the bone amount reduces, and bone density descends; The content of this process and body bone calcium, sex hormone level etc. are all closely related.
Natural drug composition of the present invention is formed by Cornu Cervi Pantotrichum, Fructus Psoraleae, Herba Epimedii, Radix Puerariae, Margarita powder five tastes natural drug prescription; It is from traditional Chinese medical science the kidney invigorating; Different mechanism of action such as doctor trained in Western medicine is replenished the calcium, replenishing collagen, sex hormone level regulation set out; Comprehensive function has embodied the advantage of drug combination in body, reaches the effect of preventing preferably and treating osteoporosis.
Cornu Cervi Pantotrichum: Cornu Cervi Pantotrichum is classical the kidney invigorating rare Chinese medicine, takes from the still unossified young horn of Cervus nippon Temminck (Cervus nippon Temminck) or Cervus elaphus linnaeus (C.Elaohus L.).Have invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening is transferred to dash and is appointed, the effect of holder sore.Compendium of Material Medica meaning Cornu Cervi Pantotrichum can " spermatogenesis is mended marrow, the tonifying YIN that nourishes blood, strengthening the tendons and bones; control that all are deficient, deaf, order is dark, dizzy dysentery of deficiency type " contain abundant bone calcium and bone collagen in the Cornu Cervi Pantotrichum; Have synergism between the two, bone calcium can increase the body calcium content and only replenish calcium can not the long term maintenance bone density improving or the effect of bone mineral content, this moment antler collagen albumen; It is calcareous at skeletal deposition that help replenishes; Keep the increase of bone density, it is active to increase osteoblast, increases the outer dia and the bone strength in cortical bone district.And have bibliographical information antler growth element to have to make that osteoporosis rat bone density due to the retinoic acid, bone are heavy, the long effect that raises of bone (Zhao Wenhai etc. the antler growth element is to the experimentation of osteoporosis rat influence due to the retinoic acid. Chinese bone injury; 2003,16 (8) .).
Fructus Psoraleae: Fructus Psoraleae is the seed of plant pulse family Fructus Psoraleae Psoraleasorylifolia L..Be recorded in Lei Gong's Treatise on Preparation and Broiling of Materia Medica the earliest, cure mainly five kinds of strain and seven kinds of impairment, the bone marrow wound loses.Li Shizhen (1518-1593 A.D.) is described Fructus Psoraleae: " its merit of Fructus Psoraleae speech also; Broken solid paper belongs to fire, can receive the sword gods; The fire of pericardium is communicated with fire from the gater of life, so Yuanyang is firm, bone marrow enriches, but Fructus Psoraleae ball strengthening bone and muscle, beneficial vigour." the reinforcing the kidney to strengthen the bone determined curative effect.Fructus Psoraleae contains the Coumarins composition, and it can play the effect of phytoestrogen, prevents bone resorption, and bone density improving (Deng Pingxiang. Fructus Psoraleae is to the experimentation of conversion of removal ovary rat bone and blood lipid metabolism influence. the new traditional Chinese medical science, 2005,37 (7): 94～96).And Fructus Psoraleae extract can promote the expression of type i collagen albumen and Bone Gla protein mRNA, promotes osteocyte propagation, thereby stimulates the effect of bone formation performance osteoporosis.
Herba Epimedii: Herba Epimedii is the dried leaves of (Epimedium brevicornu Maxim.) or (E.sittatum Maxim) or (E.pubescens Maxim) or (E.koreanum Nakai); Be traditional kidney invigorating and YANG supporting Chinese medicine; Beginning is stated from the Shennong's Herbal; Warm in nature, hide suffering, sweet, return liver, kidney channel.Function kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Modern medicine study shows that the Herba Epimedii extracting solution has the activity that suppresses broken cell; Promote simultaneously the function of osteocyte again; Calcified bone is formed to be increased; Bone formation has tangible preventive effect greater than bone resorption to removing the testis osteoporosis rat, and the occurrence probability of the osteoporosis due to the good control glucocorticoid is arranged.And its total flavones can be through promoting the secretion of osteoblast type i collagen in the removal ovary rat bone tissue, reduces the expression of osteoclast cathepsin K simultaneously and suppress the decomposition of type i collagen in the bone matrix, thereby improve rat bone density.
Radix Puerariae: Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Sweet in the mouth is flat.Cure mainly and quench one's thirst, high fever of the body, vomiting, all numbness plays cloudy gas, separates all poison.Radix Puerariae can significantly increase the whole bone density of femur, and is wherein particularly remarkable to the increase of the metaphyseal bone density of femur, and its action intensity and estrogen that increases the bone amount is suitable.Contain a large amount of osajin compositions in the Radix Puerariae, puerarin for example, and isoflavone is typical phytoestrogen, can improve bone strength and density (Zheng Gaoli. Radix Puerariae isoflavone is to prevention and treatment of osteoporosis effect and mechanism research thereof. Zhejiang University 2002.).
Margarita powder: Margarita powder is with hydriopsis cumingii Hyriopsis cumingii (Lea), cristaria plicata Cristaria plicata (Leach), pteria martensii Pteria martensii Margaritas that shell-fish produces such as (Dunker), and grinds the powder that forms.The Pharmacopoeia of the People's Republic of China and " Chinese medicine voluminous dictionary " all indicate: Margarita has effects such as the arresting convulsion of calming the nerves, the nebula that makes eye bright, removing toxic substances and promoting granulation, and modern study shows that also Margarita powder all has unique effect at aspects such as improving body immunity, slow down aging, freckle removing and whitening, supplement calcium.Margarita contains the calcium carbonate of protein (can obtain 18 seed amino acids after the hydrolysis, wherein 7 kinds is essential amino acid), aragonite structure, 20 various trace elements and vitamin B.Modern study shows that Margarita powder contains 18 seed amino acids such as leucine, methionine, alanine, and aminoacid is the lymphoid tissue organ growth, the institute that reaches maturity is essential, and pair cell internal protein synthesis rate and synthetic protein type have a significant effect.Adhere to that for a long time Margarita powder for oral administration can effectively improve the T among the human immune system, the activity of bone-marrow-derived lymphocyte, thus the enhance immunity resistance against diseases.Nutritionist research in modern age proof, the calcium amount of modern humans's daily requirement is seriously lacked of proper care with the actual calcium amount of taking in.Margarita powder is as novel calsium supplement, and positive day more receives the favor and the attention of consumer, and being praised becomes " Margarita calcium ".At first, calcium content is high, contains the activated calcium of 90-92% in the Margarita powder, and wherein pure calcium amount reaches 38-40%, is 220-240mg with taking pure calcium amount quite then if take 600mg every day.The calsium supplement calcium gluconate of the pure calcium molar ratio informal dress of Margarita powder is big 4 times, and is the calcareous of pure natural, and safety is healthy again.Secondly, the digestibility of calcium is high, and calsium supplement in the market is divided into two kinds in organic calcium and inorganic calcium; Its absorbance is between 25-32%, and calcium gluconate is 27%, and calcium citrate is 30%; The absorbance of common Margarita powder is 29%, and nano level Margarita powder absorbance is higher.So Margarita powder is a kind of good calcium complement agent.
Summary of the invention
The purpose of this invention is to provide a kind of natural drug composition with bone density improving Prevention and Treatment of Osteoporosis; It is characterized in that a kind of natural drug composition, it is characterized in that forming by Cornu Cervi Pantotrichum, Fructus Psoraleae, Herba Epimedii, Radix Puerariae, Margarita powder prescription with bone density improving Prevention and Treatment of Osteoporosis.
The principle that natural drug composition of the present invention combines based on modern pharmacological research and Traditional Chinese medical theory; From traditional Chinese medical science the kidney invigorating; Different mechanism of action such as doctor trained in Western medicine is replenished the calcium, replenishing collagen, sex hormone level regulation set out; Comprehensive function has embodied the advantage of drug combination in body, reaches the effect of preventing preferably and treating osteoporosis.Cornu Cervi Pantotrichum provides a large amount of bone calcium, and that the contained collagen protein of itself helps to replenish is calcareous at skeletal deposition.Fructus Psoraleae, Herba Epimedii, Radix Puerariae are again in the sex hormone level adjusting, and upward effect is obvious to influence the bone conversion, has promoted calcareous utilization.Margarita powder is rich in a large amount of activated calciums, and calcium-tonifying bone-strengthening is easy to absorb.A few flavor medical material mechanisms of action are different, and collaborative each other again, strengthened curative effect.And the Fructus Psoraleae in this compositions, Herba Epimedii are the enriching yin and nourishing kidney medicine, and this also meets the theory of traditional Chinese medical science kidney governing bones.The present invention has tangible novelty and technological progress.
Another innovative point of the present invention is: Cornu Cervi Pantotrichum is famous and precious resource, and in the method for preparing of the present invention, Cornu Cervi Pantotrichum is used earlier ethanol extraction, and extracting solution concentrates back reuse Cornu Cervi Pantotrichum medicinal residues combination drying, pulverizes.Cornu Cervi Pantotrichum utilizes ethanol extraction; Estradiol, cholesterol, Oleovitamin A, estrone, cerebrin, lecithin, cephalin, glycolipid, lipid sphyngomyelin etc. in the Cornu Cervi Pantotrichum are fully extracted; Be convenient to absorption of human body; The Cornu Cervi Pantotrichum medicinal residues are pulverized and are contained a large amount of collagen protein, calcareous, are the useful material of needed by human, so the pulverizing of Cornu Cervi Pantotrichum medicinal residues is taken.Simultaneously, through ethanol extraction, concentrate, after the drying, the pathogen in the Cornu Cervi Pantotrichum has obtained removing, takes safety.This is a beneficial effect of the present invention.
The present invention with respect to prior art have the pure natural determined curative effect, have no side effect, taking convenience, advantage such as cheap.
The method for preparing of natural drug composition of the present invention is following: Fructus Psoraleae, Herba Epimedii, Radix Puerariae three flavor medical materials are with 40%-95% ethanol extraction 2-3 time, 1-3 hour at every turn, filtration, filtrate recycling ethanol; Concentrate, drying, Cornu Cervi Pantotrichum is with 40%--95% alcohol reflux 2-3 time, filtration; Filtrate recycling ethanol gets concentrated solution, and the Cornu Cervi Pantotrichum slag behind the ethanol extraction is mixed drying again with concentrated solution; Pulverize, at last Margarita powder, four Chinese medicine material extract are mixed evenly, promptly get.
Composition of natural products of the present invention has the osteoporosis of control function, through following pharmacodynamic experiment be confirmed (test used Pharmaceutical composition in embodiment 2 preparation Pharmaceutical composition).
Therapeutical effect to castrated rats osteoporosis disease: mainly investigate the present composition to rat femur bone density and the exponential influence of rat femur bone, to the influence of rat blood serum calcium, serum paraoxonase, to the influence of rat femur bone ash branch, bone calcium, bone phosphorus.
Get male and female rat (body weight 160g-180g) with the anesthesia of 3% pentobarbital sodium, routine disinfection is extractd bilateral testes or ovary under aseptic condition, sew up the incision at random; Sham operated rats is only done to sew up (not excising testis and ovary) again after the abdominal operation sterilization is cut, with the rat random packet, and 10 every group; The back grouping of one week of operation is by the administration of medication group, once a day; Continuous 90 days, compositions administration group was pressed 0.50g/kg, 0.25g/kg; 0.125g/kg the administration of high, medium and low three administration groups, positive control will be selected hydroxyethyl sodium phosphate 50mg/kg for use, and matched group and model group are given and coordinative solvent.Observation index: administration finishes broken end sudden death animal; Get blood system from serum, press kit method and measure S/Ca, S/P content, get rat bilateral femur and peel meat and hetero-organization thereof off; Wherein a side femur is done bone density scanning on dual intensity X line borne densitometers, measures bone density (g/cm
2), title femur heavy (W) is surveyed bone long (L), dries 1 hour for 110 ℃, puts interior 200 ℃, 400 ℃, 600 ℃, 800 ℃ each ashing of Muffle furnace two hours again, and ashing finishes, and grey weigh (Wash) claimed in cooling, uses 6N HNO
3Extract the back and survey bone ash P, Ca content, show with the gram numerical table of 100g bone ash calcium ions or P.Above result all compares with administration group and model group, and model group and matched group are relatively.Experimental result is seen table 1,2,3.
Table 1, this compositions are to rat femur bone density and the exponential influence of rat femur bone
The Δ ΔCompare with the normal control group P＜0.01,
*P＜0.05,
*Compare with model control group P＜0.01
Table 2, this compositions are to the influence of rat blood serum calcium, serum paraoxonase
Δ
ΔCompare with the normal control group P＜0.01,
*Compare with model control group P＜0.05
Table 3, this compositions are to the influence of rat femur bone ash branch, bone calcium, bone phosphorus
The Δ ΔCompare with the normal control group P＜0.01,
*P＜0.05,
*Compare with model control group P＜0.01
Above result shows that the compositions of mentioning among the present invention all has appreciable impact to castrated rats femoral bmd, bone weight, bone ash weight, bone calcium, bone phosphorus, makes its increase, and to not influence of bone length, serum calcium is increased, and serum paraoxonase is not had influence.
The compositions of mentioning among the present invention in sum has bone density improving, prevents and treats osteoporotic effect.
The present invention carries out detailed explanation through following embodiment, but does not mean that the present invention only limits to this, and specific embodiments is following:
Embodiment 1The extraction preparation of compositions
It is subsequent use to get Margarita powder 50g; Fructus Psoraleae 200g, Herba Epimedii 200g, Radix Puerariae 200g each 1 hour, filter filtrate recycling ethanol with 70% ethanol extraction 3 times; Concentrate, drying, Cornu Cervi Pantotrichum 400g is with 80% alcohol reflux 3 times, filtration; Filtrate recycling ethanol gets concentrated solution, and the Cornu Cervi Pantotrichum slag behind the ethanol extraction is mixed drying again with concentrated solution; Pulverize, at last Margarita powder, four Chinese medicine material extract are mixed evenly, promptly get.
Embodiment 2The extraction preparation of compositions
It is subsequent use to get Margarita powder 50g; Fructus Psoraleae 250g, Herba Epimedii 250g, Radix Puerariae 200g three flavor medical materials are with 80% ethanol extraction 3 times, each 1 hour, filtration, filtrate recycling ethanol; Concentrate, drying, Cornu Cervi Pantotrichum 300g is with 90% alcohol reflux 3 times, filtration; Filtrate recycling ethanol gets concentrated solution, and the Cornu Cervi Pantotrichum slag behind the ethanol extraction is mixed drying again with concentrated solution; Pulverize, at last Margarita powder, four Chinese medicine material extract are mixed evenly, promptly get.
Claims (5)
1. the natural drug composition of a bone density improving, Prevention and Treatment of Osteoporosis is characterized in that being formed by Cornu Cervi Pantotrichum, Fructus Psoraleae, Herba Epimedii, Radix Puerariae, Margarita powder prescription.
2. natural drug composition according to claim 1; It is characterized in that described Cornu Cervi Pantotrichum is the still unossified young horn of Cervus nippon Temminck Cervus nippon Temminck or Cervus elaphus linnaeus C.Elaohus L.; Fructus Psoraleae is the seed of leguminous plant Psoralea sorylifolia L.; Herba Epimedii is the dried leaves of Epimedium brevicornu Maxim or E.sittatum Maxim or E.pubescens Maxim or E.koreanum Nakai; Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata Willd Ohwi; Margarita powder is the Margaritas that shell-fish produced such as hydriopsis cumingii Hyriopsis cumingii Lea, cristaria plicata Cristaria plicata Leach, pteria martensii Pteria martensii Dunker, grinds the powder that forms.
3. natural drug composition according to claim 1 is characterized in that being processed by the raw material of following weight parts: Cornu Cervi Pantotrichum 200-500 part, Fructus Psoraleae 150-400 part, Herba Epimedii 150-400 part, Radix Puerariae 200-500 part, Margarita powder 20-50 part.
4. according to claim 1 and 2 described natural drug compositions, its preparation method is following:
(1) it is subsequent use to get Margarita powder;
(2) Cornu Cervi Pantotrichum filters with 40%-95% alcohol reflux 2-3 time, filtrate recycling ethanol, concentrated solution, the Cornu Cervi Pantotrichum slag behind the ethanol extraction is mixed again drying, pulverizing with concentrated solution;
(3) Fructus Psoraleae, Herba Epimedii, Radix Puerariae three flavor medical materials are with 40%-95% ethanol extraction 2-3 time, and each 1-3 hour, filter, filtrate recycling ethanol, concentrated, drying, pulverizing;
(4) with Margarita powder, Cornu Cervi Pantotrichum extract, Fructus Psoraleae, Herba Epimedii, Radix Puerariae extract mix homogeneously, promptly get.
5. according to claim 1 and 2 described composition of natural products, mix with pharmaceutic adjuvant, process oral formulations, it can be in hard capsule, soft capsule, tablet, granule, powder, the pill any one.
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| CN104800532A (en) * | 2015-04-13 | 2015-07-29 | 青岛华仁技术孵化器有限公司 | Calcium supplementing substances used in health food |
| CN105768094A (en) * | 2016-04-19 | 2016-07-20 | 长春康彼达科技有限公司 | Health-care food for increasing bone density and making method thereof |
| CN108186717A (en) * | 2018-03-05 | 2018-06-22 | 吉林农业大学 | Have the function of to increase bone density, the pilose antler Psoralen oil/fat composition for preventing osteoporosis and its preparation method and application |
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| CN104800532A (en) * | 2015-04-13 | 2015-07-29 | 青岛华仁技术孵化器有限公司 | Calcium supplementing substances used in health food |
| CN105768094A (en) * | 2016-04-19 | 2016-07-20 | 长春康彼达科技有限公司 | Health-care food for increasing bone density and making method thereof |
| CN108186717A (en) * | 2018-03-05 | 2018-06-22 | 吉林农业大学 | Have the function of to increase bone density, the pilose antler Psoralen oil/fat composition for preventing osteoporosis and its preparation method and application |
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Application publication date: 20120801 |