CN101804165A - Preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and preparation method thereof - Google Patents

Abstract

The invention relates to a preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and a preparation method thereof. The preparation comprises more than 80 Chinese medicines, such as rare local tyrant, cordyceps sinensis, ganoderma lucidum, astragalus, lyceum, quangui, quanbie, polygonum, rosa roxburghii tratt juice, rootless vine, russian boschniakia, sealwort, cornus, epimedium, ginseng, deerhorn gelatin, pearl powder, pueraria, cassia, plum participation, royal fetal and the like. The preparation method comprises the following steps that: ganoderma lucidum, astragalus and the like are soaked, steamed, stewed, semi-dried and sliced with the original juice removed, dried, epimedium is fried to be yellow, the pearl powder water is ground, the quangui, the quanbie and the like are dried and crushed, mixed and then added with rosa roxburghii tratt juice and femented with local tyrant, to prepare the mother solution of the local tyrant; the ginseng, colla corii asini, aloe, goat placenta powder and the like are crushed, alcohol is extracted, to prepare liquid medicine; and the liquid medicine is mixed with the mother solution of the local tyrant to prepare the preparation. The invention has a unique, scientific and reasonable formula, can regulate and improve the kidney functions by adding a reasonable preparation process, improve the body immunity, strengthening the internal organs, enhancing physique and preventing aging.

Description

A kind of clearing kidney toxicity, the strong vital organs of the human body, preparation of health invigorating slow down aging and preparation method thereof

Technical field

The present invention relates to a kind of clearing kidney toxicity, the strong vital organs of the human body, preparation of health invigorating slow down aging and preparation method thereof.

Background technology

The strong in the market vital organs of the human body, the preparation that comprehensively strengthens human body constitution has a lot.Its prescription is different, the effect difference.As " Chinese medicine preparation of a kind of health invigorating, allaying tiredness " (Chinese patent application number 200610170948), it is Cordyceps, Ganoderma, male bombyx mori, Cornu Cervi Pantotrichum, Herba Epimedii, Folium Allii tuberosi seed, Poria, Auricularia, Herba Cistanches, the Radix Astragali, Fructus Ligustri Lucidi, Fructus Lycii, Radix Salviae Miltiorrhizae, Fructus Jujubae, Rhizoma Zingiberis Recens, Arillus Longan, Radix Rehmanniae, Colla Corii Asini, Rhizoma Dioscoreae, Radix Rhodiolae, Cortex Cinnamomi and Folium Ginkgo that raw material is formed." a kind of pharmaceutical composition that strengthens hepatogastric function " (Chinese patent application number 200410089343), by the Radix Paeoniae Alba, white lotus, Semen Coicis, water caltrop pulp, Poria, Rhizoma Dioscoreae is that primary raw material is formed.

Summary of the invention

The objective of the invention is at above-mentioned present situation, aim to provide a kind of energy clearing kidney toxicity, the strong vital organs of the human body, preparation of health invigorating slow down aging and preparation method thereof.

The implementation of the object of the invention is, a kind of clearing kidney toxicity, and the strong vital organs of the human body, the preparation of health invigorating slow down aging, form by following components by weight proportion:

Cordyceps militaris (L.) Link. 13-16 gram Cornu Cervi Pantotrichum 14-17 gram Radix Codonopsis 19-22 gram

Caulis Spatholobi 12-16 gram Radix Rehmanniae Preparata 19-23 gram Fructus Mori 23-26 gram

Gecko 14-17 gram Rhizoma Anemarrhenae 12-16 gram Fructus Ligustri Lucidi 13-17 gram

Folium Ginkgo 13-16 gram Semen Vitis viniferae extract 13-17 gram Margarita powder 13-16 gram

Propolis 13-16 gram Radix Puerariae 14-17 gram Fructus Hippophae 12-16 gram

Poria 14-17 gram Arillus Longan 17-21 Keshan short, bristly hair or beard 12-16 gram

Fructus Rosae Laevigatae 12-16 gram Semen Coicis 12-17 gram Semen Persicae 13-17 gram

Pericarpium Citri Reticulatae 17-21 gram Rhizoma Polygonati Odorati 13-16 gram Folium Nelumbinis 18-21 gram

Ganoderma's 300 gram Aloe 48-52 gram Radix Angelicae Sinensis 38-41 grams

Radix Ginseng 23-26 gram Colla Corii Asini 38-41 gram Foetus Caprae seu Ovis powder 48-52 gram

Cordyceps 13-16 kairine sesame 14-16 gram Radix Astragali 23-26 gram

Fructus Lycii 28-31 gram QUANGUI 13-16 gram Trionyx sinensis (Wiegmann) 18-22 gram

Radix Polygoni Multiflori 23-26 gram Sucus Rosae Normalis 14-17 gram Radix Glycyrrhizae 14-16 gram

Dodder laurel 13-16 gram Herba Cynomorii 14-18 gram Rhizoma Polygonati 13-16 gram

Fructus Corni 12-16 gram Herba Epimedii 13-17 gram Radix Panacis Quinquefolii 18-21 gram

Colla cornus cervi 13-16 gram Semen Cassiae 18-21 gram Thelenota ananas (Jaeger) 13-16 gram

HUANGTAI 14-17 gram.

A kind of clearing kidney toxicity, the strong vital organs of the human body, the preparation method of health invigorating slow down aging preparation, concrete steps are as follows:

(1) 14-17 is restrained Cornu Cervi Pantotrichum, 19-22 gram Radix Codonopsis, 12-16 gram Caulis Spatholobi, 14-16 kairine sesame, the 23-26 gram Radix Astragali, 13-16 gram Thelenota ananas (Jaeger), 23-26 gram Radix Polygoni Multiflori and remove impurity, soaked 12-24 hour, clean, pick up, greatly only rive, midway trickle, run through, put in the food steamer, steamed foot 8 hours every day, stewing spending the night, stir up and down next morning 1 time, steam again, steam 4 days so repeatedly, stewing 4 nights, all be moist black to inside and outside, take out, shine to half-dried shave, the natural juice of gained is admixed in the time of will steaming, make it to exhaust drying, sieve dedust bits;

(2) with 12-16 Keshan short, bristly hair or beard, 13-17 restrains Semen Persicae, Herba Epimedii 13-17 restrains into a pot parching to brown, 13-16 gram Margarita powder adopts elutriation to grind, and 13-16 restrains Cordyceps militaris (L.) Link., 19-23 restrains Radix Rehmanniae Preparata, 23-26 restrains Fructus Mori, 14-17 restrains Gecko, 12-16 restrains the Rhizoma Anemarrhenae, 13-17 restrains Fructus Ligustri Lucidi, 13-16 restrains Folium Ginkgo, 13-16 restrains propolis, 14-17 restrains Radix Puerariae, 12-16 restrains Fructus Hippophae, 14-17 restrains Poria, 17-21 restrains Arillus Longan, 12-16 restrains Fructus Rosae Laevigatae, 12-17 restrains Semen Coicis, 17-21 restrains Pericarpium Citri Reticulatae, 13-16 restrains Rhizoma Polygonati Odorati, 18-21 restrains Folium Nelumbinis, 13-16 restrains Cordyceps, 28-31 restrains Fructus Lycii, 13-16 restrains QUANGUI, 18-22 restrains Trionyx sinensis (Wiegmann), 14-16 restrains Radix Glycyrrhizae, 13-16 restrains dodder laurel, 14-18 restrains Herba Cynomorii, 13-16 restrains Rhizoma Polygonati, the 12-16 Keshan Fructus Evodiae, 18-21 restrains Radix Panacis Quinquefolii, 13-16 restrains Colla cornus cervi, 18-21 restrains Semen Cassiae, the oven dry of 14-17 gram HUANGTAI, pulverize, mix;

Said mixture and step (1) gains are mixed, add 13-17 gram Semen Vitis viniferae extract again, 14-17 gram Sucus Rosae Normalis restrains Ganodermas with 300 and places fermentation tank, the mineral water that adds 3600 milliliters, slowly rotate clockwise, the temperature that controls environment is 20-26 ℃, and humidity 35%--65% goes through fermentation in 6--8 month under sealing condition, after filtration, remove slag, receive juice, obtain concentration and be 70 ± 2% TAISUIMUYE;

(3) 48-52 is restrained Aloe, 38-41 gram Radix Angelicae Sinensis, 23-26 gram Radix Ginseng, 38-41 gram Colla Corii Asini, 48-52 gram Foetus Caprae seu Ovis powder drying, pulverize, cross 100 mesh sieves with Universalpulverizer, causing blender mixes all, taking-up places extraction pot, add 800 ml concns and be 75% ethanol, soaked 2 hours, adopt the extraction of CO 2 fluid abstraction technique, filter, concentrate, obtain pale brown color medicinal liquid, through alkali treatment, cross macropore adsorption chromatography post, 95% ethanol elution, reclaim under reduced pressure concentrates, and obtaining concentration is 70 ± 2% medicinal liquids;

(4) be 1: 3 mixed by weight with step (2) gained TAISUIMUYE and step (3) gained medicinal liquid, shelved 48-72 hour, filter that sterilization gets preparation.

The present invention utilizes solid molecular dispersion technology to be prepared into the high and bioavailability height of stability for increasing the dissolubility and the stability of ingredient, absorbs fast compound preparation.

The present invention's uniqueness of filling a prescription, scientific and reasonable, add rational preparation technology, the preparation of production includes more than 100 kind of necessary for human body bioactive ingredients such as multidimensional peptide, pyrroles's quinoline a kind of jade (PQQ) and protein, aminoacid, nucleic acid, polysaccharide, flavone, Saponin, glycoside, vitamin, profitable strain, trace element.

This preparation can be regulated renal function, can alleviate the nephropathy of chronic disease, improve renal function, alleviate the infringement of toxicant kidney, promote the Excretion of kidney, remove the kidney toxin, human body immunity improving power is regulated the enhancing heart, liver, spleen, stomach, kidney, lung, large intestine, small intestinal, bladder, three warmers, cholic allomeric function, promptly has clearing kidney toxicity, the strong vital organs of the human body, the health invigorating function in delaying senility has certain effect to the common disease of person in middle and old age.

The specific embodiment

This preparation is by natural rare Ganoderma and Cordyceps, Ganoderma, Cordyceps militaris (L.) Link., Cornu Cervi Pantotrichum, the Radix Astragali, Radix Codonopsis, Caulis Spatholobi, Radix Rehmanniae Preparata, Fructus Mori, Fructus Lycii, QUANGUI, Trionyx sinensis (Wiegmann), Gecko, the Rhizoma Anemarrhenae, Radix Polygoni Multiflori, Sucus Rosae Normalis, Radix Glycyrrhizae, Fructus Ligustri Lucidi, dodder laurel, Herba Cynomorii, Rhizoma Polygonati, Fructus Corni, Herba Epimedii, Radix Panacis Quinquefolii, Colla cornus cervi, Folium Ginkgo, Semen Vitis viniferae extract, Margarita powder, propolis, Radix Puerariae, Fructus Hippophae, Semen Cassiae, Poria, Arillus Longan, Fructus Crataegi, Fructus Rosae Laevigatae, Semen Coicis, Semen Persicae, Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Folium Nelumbinis, Thelenota ananas (Jaeger), HUANGTAI, Radix Ginseng, Aloe, Colla Corii Asini, Radix Angelicae Sinensis, 80 pleasant impression Chinese medicines such as Foetus Caprae seu Ovis powder are formed.

Wherein the Ganoderma is mainly contained compositions such as nucleic acid, lecithin, chitin, pyrroloquinoline quinone, albumin, flavonoid, polysaccharide." nucleic acid " has antioxidation, anti-radical action, repairs impaired organ, strengthens the human organ function, strengthens brain and nervous function, and liver and other endocrine organs' function, raise immunity are strengthened in protection; Contained " lecithin " has too much toxin in the liver protecting, cholesterol reducing, memory reinforcing, the energy decomposer; " chitin " has immunomodulating, regulates pH value, regulates hormone, prevents aging, gets rid of unnecessary bad cholesterol, gets rid of toxin, and immunologic function is strengthened.The pyrroloquinoline quinone (PQQ) that " Ganoderma " is contained experimental results show that the speed of its kill tumor cell and completeness have reached unprecedented height, is the human up to now the most potent bioactive substance of finding improving immunology." polysaccharide " that the Ganoderma is contained studies have shown that, and be more remarkable than ganoderan effect, can improve body immunity and human body hypoxia-bearing capability, eliminate free radical, suppress tumor, anti-radiation improves liver, bone marrow, blood synthetic DNA, RNA and protein ability, life lengthening etc.

Ganoderma's strengthening the body resistance has concurrently and fills blood, and equilibrium between yin and yang is regulated in enriching yin and nourishing kidney, building body, and effects such as toxin expelling with all medicine compatibilities, strengthen effect.In addition, in this prescription, Qi-tonifying drug and kidney yang-tonifying medicinal dual-purpose such as Cordyceps militaris (L.) Link., Cordyceps, Radix Codonopsis, Cornu Cervi Pantotrichum, Herba Epimedii, Fructus Mori, Gecko, Rhizoma Anemarrhenae compatibility.The same usefulness of drugs for nourishing yin and blood-nourishing drugs is as QUANGUI, Trionyx sinensis (Wiegmann), Radix Panacis Quinquefolii, Herba Cynomorii, Radix Polygoni Multiflori, Sucus Rosae Normalis, Caulis Spatholobi, Colla cornus cervi, Thelenota ananas (Jaeger), Rhizoma Polygonati compatibility.With the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Process etc. by salt in the side that the concocting method priming is descending goes into kidney, make it to have clearing kidney toxicity, invigorating primordial QI, the effect of conditioning comprehensively.Wherein Cordyceps militaris (L.) Link. has good cancer-resisting, antiviral, removing toxins in human body, enhancing human immunity, multiple function such as antioxidation.Cornu Cervi Pantotrichum contains than Radix Ginseng more rich in amino acid, lecithin, vitamin and trace element etc., and Cornu Cervi Pantotrichum is the good systemic antasthenic.Radix Codonopsis has spleen reinforcing, QI invigorating, promotes the production of body fluid, lung heat clearing, the effect of quenching the thirst.Caulis Spatholobi is enriched blood, and invigorates blood circulation collateral dredging.The Radix Rehmanniae Preparata clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening.Fructus Mori has nourishing YIN and benefiting blood, promotes the production of body fluid, the intestine moistening effect.Gecko energy tonifying the lung gas helps kidney yang, and Dingchuan is coughed, benefiting essence-blood.The Rhizoma Anemarrhenae has clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, laxation effect.Fructus Ligustri Lucidi energy tonifying liver kidney yin, strong waist knee joint, crow must make eye bright.Folium Ginkgo has the promoting blood circulation and stopping pain effect.Propolis is natural broad ectrum antibiotic, natural immunity reinforcing agent, the Natural antioxidant, blood " street cleaner " and healthy patron saint.Margarita powder can enhancing immunity, supplement calcium, Bao Chunyan decline, improvement is slept, treat ulcer, nourishing the liver to improve visual acuity, secondary buck.The blood fat reducing of Radix Puerariae energy, blood pressure lowering, pathogenic fire reducing, heat clearing away, enhancing immunity, control cardiovascular and cerebrovascular disease, blood sugar lowering.Fructus Hippophae is blood pressure regulation, blood fat, blood glucose effectively, directly removes peroxylradicals, and spleen invigorating, sharp lung, removing dampness YIN nourishing strengthen immune function of human body.Poria has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Arillus Longan has enriching yin and nourishing kidney, invigorating the spleen and replenishing QI, lung moistening, appetizing strengthening the spleen reinforcing the heart spleen, replenishing QI and blood effect.Fructus Crataegi can reduce the deposition of Animal fat in blood vessel wall, has certain to prevent or alleviate arteriosclerotic effect that the mill that can help digestion is long-pending, aid digestion, is good for the stomach.Fructus Rosae Laevigatae has reinforcing the kidney and controlling nocturnal emission, effects such as reducing urination and antidiarrheal.Semen Coicis has effects such as inducing diuresis to remove edema, spleen invigorating are dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus.Semen Persicae has kidney invigorating and YANG supporting, astringing lung QI for relieving asthma, the effect of blood stasis removing and clots absorbing, loosening bowel to relieve constipation.Pericarpium Citri Reticulatae is led cold-evil in the heart, the broken gas that stagnates, strengthening the spleen stomach effect.Effects such as Rhizoma Polygonati Odorati has blood sugar lowering, replenishing YIN and removing heat, the cough-relieving of promoting the production of body fluid.Folium Nelumbinis energy heat-clearing and toxic substances removing, diuresis has the effect of blood pressure lowering, blood fat reducing, fat-reducing.Aloe can heart tonifying be invigorated blood circulation, eliminating inflammation and expelling toxin, antitumor, improves immunity.Radix Angelicae Sinensis can blood circulation promoting, improve immunity, protect the liver kidney, pain-stopping anti-tumor, antioxidation and removing free radical radioprotective.Radix Ginseng blood pressure lowering, blood fat reducing, protection heart strengthen the aging of the anti-liver poison of renal function anti-tumor.Colla Corii Asini has tangible blood tonification effect, can improve calcium balance in the animal body.Foetus Caprae seu Ovis powder can be regulated female incretion, strengthens cell viability and improves human immunologic function's slow down aging.Cordyceps energy invigorating the lung and the kidney is regulated body's immunity, relievings asthma, protects renal function, is strengthened effects such as hemopoietic function, slow down aging, also has protecting the liver, suppresses organ transplant rejection, suppresses effects such as lupus erythematosus, blood sugar lowering, antitumor.Ganoderma contains several physiological active substances, can regulate, strengthen body immunity, neurasthenia, rheumatic arthritis, coronary heart disease, hypertension, hepatitis, diabetes, tumor etc. there is good synergistic therapeutic action, also has resisting fatigue, looks improving and the skin nourishing, slow down aging is prevented and treated effects such as AIDS.

Herba Cynomorii has kidney invigorating and YANG supporting, loosening bowel to relieve constipation, body-building, life lengthening effect.The dodder laurel clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.Rhizoma Polygonati energy nourishing kidney lung moistening, invigorating the spleen and replenishing QI.The Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming.The Radix Astragali has the effect of invigorating QI to consolidate the body surface resistance, hidroschesis detoxification, granulation promoting, diuresis, detumescent.The invigorating middle warmer of Radix Astragali Preparata QI invigorating.The Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight, the scalable body's immunity, can effectively suppress tumor growth and cell mutation, have slow down aging, anti-fatty liver, blood lipid regulation and blood glucose, the effect of aspect such as promotion hemopoietic function.Trionyx sinensis (Wiegmann): Carapax Trionycis replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, hard masses softening and resolving; Carnis Trionycis YIN nourishing removing heat from blood.QUANGUI: Carapax et Plastrum Testudinis YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, key bone; The Carnis Testudinis YIN nourishing, enrich blood.The Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening can promote hemopoietic function, the human body immunity improving function, blood fat reducing, atherosclerosis protects the liver, slow down aging, loosening bowel to relieve constipation.Sucus Rosae Normalis has antioxidation, study of anti-atherogenic effect.Semen Vitis viniferae extract has the powerful effect of removing free radical, improving body immunity.The invigorating kidney-YANG of Herba Epimedii energy, hard muscles and bones, wind-damp dispelling.Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, the double effects that the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, pathogenic fire reducing are relieved summer heat.The Colla cornus cervi enrich and benefit essence and blood.The liver heat removing of Semen Cassiae energy makes eye bright diuretic, relieving constipation.Radix Glycyrrhizae energy invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Thelenota ananas (Jaeger) can the kidney invigorating, benefit is smart, nourish blood.HUANGTAI nourishes blood and allays excitement, the liver benefiting spleen invigorating.

All medicines are with using, add rational technology, the preparation of producing can be regulated renal function, can alleviate the nephropathy of chronic disease, improve renal function, alleviate the infringement of toxicant to kidney, promote the Excretion of kidney, remove the kidney toxin, human body immunity improving power is regulated the enhancing heart, liver, spleen, stomach, kidney, lung, large intestine, small intestinal, bladder, three warmers, cholic allomeric function, promptly has clearing kidney toxicity, the strong vital organs of the human body strengthen the human body constitution function in delaying senility comprehensively, and the common disease of person in middle and old age is had certain effect.

Enumerate specific embodiments of the invention below.

Impurity is removed with 15 gram Cornu Cervi Pantotrichums, 20 gram Radix Codonopsis, 15 gram Caulis Spatholobis, 14 kairine sesames, the 23 gram Radixs Astragali, 16 gram Thelenota ananas (Jaeger), 25 gram Radix Polygoni Multiflori in example 1, (1), soaks 16 hours, cleans, and picks up, greatly only rive, trickle runs through midway, puts in the food steamer, steamed foot 8 hours every day, and stewing spending the night stirred up and down 1 next morning, steams again, steam 4 days so repeatedly, all be moist black to inside and outside stewing 4 nights, take out, shine to half-dried, shave, the natural juice of gained is admixed in the time of will steaming, make it to exhaust drying, sieve dedust bits;

(2) with 15 Keshan short, bristly hair or beards, 15 gram Semen Persicaes, 15 gram Herba Epimedii are gone into a pot parching to brown, 15 gram Margarita powder adopt elutriation to grind, 15 gram Cordyceps militaris (L.) Link., 20 gram Radix Rehmanniaes Preparata, 25 gram Fructus Mori, 15 gram Geckos, the 15 gram Rhizoma Anemarrhenaes, 15 gram Fructus Ligustri Lucidi, 15 gram Folium Ginkgos, 15 gram propolis, 15 gram Radix Puerariaes, 16 gram Fructus Hippophaes, 15 gram Poria, 20 gram Arillus Longans, 15 gram Fructus Rosae Laevigatae, 15 gram Semen Coiciss, 20 gram Pericarpium Citri Reticulataes, 15 gram Rhizoma Polygonati Odorati, 18 gram Folium Nelumbinis, 15 gram Cordyceps, 30 gram Fructus Lycii, 15 gram QUANGUI, 20 gram Trionyx sinensis (Wiegmann), 15 gram Radix Glycyrrhizaes, 13 gram dodder laurels, 15 gram Herba Cynomorii, 16 gram Rhizoma Polygonatis, the 15 Keshan Fructus Evodiaes, 20 gram Radix Panacis Quinquefoliis, 13 gram Colla cornus cervis, 20 gram Semen Cassiaes, 15 gram HUANGTAI oven dry, pulverize, mix;

Said mixture and step (1) gains are mixed, add 15 gram Semen Vitis viniferae extracts again, 14 gram Sucus Rosae Normalis restrain Ganodermas with 300 and place fermentation tank, the mineral water that adds 3600 milliliters, slowly rotate clockwise, the temperature that controls environment is 23-26 ℃, and humidity 45%--55% goes through 7 first quarter moon fermentations under sealing condition, after filtration, remove slag, receive juice, obtain concentration and be 72% TAISUIMUYE;

(3) with 50 gram Aloes, 40 gram Radix Angelicae Sinensis, 23 gram Radix Ginsengs, 40 gram Colla Corii Asini, 50 gram Foetus Caprae seu Ovis powder dryings, pulverize, cross 100 mesh sieves, cause blender and mix all with Universalpulverizer, taking-up places extraction pot, adds 800 ml concns and be 75% ethanol, soaks 2 hours, adopt the extraction of CO 2 fluid abstraction technique, filter, concentrate, obtain pale brown color medicinal liquid, through alkali treatment, cross macropore adsorption chromatography post, 95% ethanol elution, reclaim under reduced pressure concentrates, and obtaining concentration is 71% medicinal liquid;

(4) be 1: 3 mixed by weight with step (2) gained TAISUIMUYE and step (3) gained medicinal liquid, shelved 48 hours, filter that sterilization gets preparation.

Example 2, with example 1, different is: get 15 gram Cornu Cervi Pantotrichums, 21 gram Radix Codonopsis, 12 gram Caulis Spatholobis, 15 kairine sesames, the 24 gram Radixs Astragali, 13 gram Thelenota ananas (Jaeger), 23 gram Radix Polygoni Multiflori and soaked 20 hours.

Get 14 gram Cordyceps militaris (L.) Link., 21 gram Radix Rehmanniaes Preparata, 25 gram Fructus Mori, 14 gram Geckos, the 13 gram Rhizoma Anemarrhenaes, 14 gram Fructus Ligustri Lucidi, 16 gram Folium Ginkgos, 14 gram Margarita powder, 16 gram propolis, 14 gram Radix Puerariaes, 12 gram Fructus Hippophaes, 15 gram Poria, 17 gram Arillus Longans, 14 Keshan short, bristly hair or beards, 15 gram Fructus Rosae Laevigatae, 14 gram Semen Coiciss, 16 gram Semen Persicaes, 19 gram Pericarpium Citri Reticulataes, 14 gram Rhizoma Polygonati Odorati, 20 gram Folium Nelumbinis, 14 gram Cordyceps, 28 gram Fructus Lycii, 14 gram QUANGUI, 21 gram Trionyx sinensis (Wiegmann), 14 gram Radix Glycyrrhizaes, 15 gram dodder laurels, 16 gram Herba Cynomorii, 15 gram Rhizoma Polygonatis, the 14 Keshan Fructus Evodiaes, 16 gram Herba Epimedii, 18 gram Radix Panacis Quinquefoliis, 16 gram Colla cornus cervis, 19 gram Semen Cassiaes, 17 gram HUANGTAI, 16 gram Semen Vitis viniferae extracts, 17 gram Sucus Rosae Normalis, 52 gram Aloes, 39 gram Radix Angelicae Sinensis, 25 gram Radix Ginsengs, 38 gram Colla Corii Asini, 48 gram Foetus Caprae seu Ovis powder, 300 gram Ganodermas.The temperature that controls environment is 22-25 ℃, and humidity 40%--55% goes through the fermentation of 6 first quarter moons under sealing condition, step (2) concentration is 68% TAISUIMUYE, step (3) concentration is 69% medicinal liquid.Step (2) gained TAISUIMUYE is mixed with step (3) gained medicinal liquid, shelved 60 hours.

Example 3, with example 1, different is: get 16 gram Cornu Cervi Pantotrichums, 19 gram Radix Codonopsis, 16 gram Caulis Spatholobis, 16 kairine sesames, the 25 gram Radixs Astragali, 15 gram Thelenota ananas (Jaeger), 25 gram Radix Polygoni Multiflori and soaked 24 hours.

Get 14 Keshan short, bristly hair or beards, 15 gram Semen Persicaes, 15 gram Margarita powder, 13 gram Cordyceps militaris (L.) Link., 22 gram Radix Rehmanniaes Preparata, 23 gram Fructus Mori, 13 gram Geckos, the 12 gram Rhizoma Anemarrhenaes, 13 gram Fructus Ligustri Lucidi, 14 gram Folium Ginkgos, 14 gram propolis, 17 gram Radix Puerariaes, 12 gram Fructus Hippophaes, 16 gram Poria, 18 gram Arillus Longans, 13 gram Fructus Rosae Laevigatae, 12 gram Semen Coiciss, 20 gram Pericarpium Citri Reticulataes, 14 gram Rhizoma Polygonati Odorati, 21 gram Folium Nelumbinis, 14 gram Cordyceps, 29 gram Fructus Lycii, 14 gram QUANGUI, 21 gram Trionyx sinensis (Wiegmann), 14 gram Radix Glycyrrhizaes, 15 gram dodder laurels, 16 gram Herba Cynomorii, 13 gram Rhizoma Polygonatis, the 12 Keshan Fructus Evodiaes, 16 gram Herba Epimedii, 18 gram Radix Panacis Quinquefoliis, 16 gram Colla cornus cervis, 19 gram Semen Cassiaes, 16 gram HUANGTAI, 17 gram Semen Vitis viniferae extracts, 15 gram Sucus Rosae Normalis, 48 gram Aloes, 40 gram Radix Angelicae Sinensis, 26 gram Radix Ginsengs, 38 gram Colla Corii Asini, 51 gram Foetus Caprae seu Ovis powder, 300 gram Ganodermas.The temperature that controls environment is 21-25.5 ℃, and humidity 45%--65% goes through fermentation in 7 months under sealing condition, step (2) concentration is 70% TAISUIMUYE, step (3) concentration is 70% medicinal liquid.Step (2) gained TAISUIMUYE is mixed with step (3) gained medicinal liquid, shelved 48 hours.

Example 4, with example 1, different is: get 17 gram Cornu Cervi Pantotrichums, 20 gram Radix Codonopsis, 13 gram Caulis Spatholobis, 16 kairine sesames, the 25 gram Radixs Astragali, 16 gram Thelenota ananas (Jaeger), 26 gram Radix Polygoni Multiflori and soaked 12 hours.

Get 12 Keshan short, bristly hair or beards, 13 gram Semen Persicaes, 13 gram Margarita powder, 16 gram Cordyceps militaris (L.) Link., 19 gram Radix Rehmanniaes Preparata, 26 gram Fructus Mori, 16 gram Geckos, the 15 gram Rhizoma Anemarrhenaes, 17 gram Fructus Ligustri Lucidi, 15 gram Folium Ginkgos, 15 gram propolis, 16 gram Radix Puerariaes, 15 gram Fructus Hippophaes, 14 gram Poria, 19 gram Arillus Longans, 12 gram Fructus Rosae Laevigatae, 13 gram Semen Coiciss, 17 gram Pericarpium Citri Reticulataes, 13 gram Rhizoma Polygonati Odorati, 19 gram Folium Nelumbinis, 15 gram Cordyceps, 30 gram Fructus Lycii, 13 gram QUANGUI, 18 gram Trionyx sinensis (Wiegmann), 16 gram Radix Glycyrrhizaes, 13 gram dodder laurels, 14 gram Herba Cynomorii, 16 gram Rhizoma Polygonatis, the 13 Keshan Fructus Evodiaes, 13 gram Herba Epimedii, 20 gram Radix Panacis Quinquefoliis, 15 gram Colla cornus cervis, 20 gram Semen Cassiaes, 15 gram HUANGTAI, 13 gram Semen Vitis viniferae extracts, 16 gram Sucus Rosae Normalis, 49 gram Aloes, 38 gram Radix Angelicae Sinensis, 23 gram Radix Ginsengs, 41 gram Colla Corii Asini, 52 gram Foetus Caprae seu Ovis powder, Ganoderma's 300 grams.The temperature that controls environment is 22-25 ℃, and humidity 35%--55% goes through fermentation in 6 months under sealing condition, step (2) concentration is 68% TAISUIMUYE, step (3) concentration is 68% medicinal liquid.Step (2) gained TAISUIMUYE is mixed with step (3) gained medicinal liquid, shelved 72 hours.

Example 5, with example 1, different is: get 16 gram Cornu Cervi Pantotrichums, 22 gram Radix Codonopsis, 15 gram Caulis Spatholobis, 15 kairine sesames, the 26 gram Radixs Astragali, 13 gram Thelenota ananas (Jaeger), 23 gram Radix Polygoni Multiflori and soaked 22 hours.

Get 15 Keshan short, bristly hair or beards, 15 gram Semen Persicaes, 16 gram Margarita powder, 15 gram Cordyceps militaris (L.) Link., 23 gram Radix Rehmanniaes Preparata, 23 gram Fructus Mori, 17 gram Geckos, the 16 gram Rhizoma Anemarrhenaes, 13 gram Fructus Ligustri Lucidi, 16 gram Folium Ginkgos, 13 gram propolis, 16 gram Radix Puerariaes, 13 gram Fructus Hippophaes, 15 gram Poria, 21 gram Arillus Longans, 16 gram Fructus Rosae Laevigatae, 15 gram Semen Coiciss, 21 gram Pericarpium Citri Reticulataes, 15 gram Rhizoma Polygonati Odorati, 20 gram Folium Nelumbinis, 13 gram Cordyceps, 30 gram Fructus Lycii, 16 gram QUANGUI, 18 gram Trionyx sinensis (Wiegmann), 15 gram Radix Glycyrrhizaes, 16 gram dodder laurels, 15 gram Herba Cynomorii, 14 gram Rhizoma Polygonatis, the 16 Keshan Fructus Evodiaes, 17 gram Herba Epimedii, 21 gram Radix Panacis Quinquefoliis, 14 gram Colla cornus cervis, 21 gram Semen Cassiaes, 14 gram HUANGTAI, 14 gram Semen Vitis viniferae extracts, 17 gram Sucus Rosae Normalis, 48 gram Aloes, 41 gram Radix Angelicae Sinensis, 24 gram Radix Ginsengs, 39 gram Colla Corii Asini, 50 gram Foetus Caprae seu Ovis powder, 300 gram Ganodermas.The temperature that controls environment is 22-26 ℃, and humidity 45%--65% goes through fermentation in 8 months under sealing condition, step (2) concentration is 72% TAISUIMUYE, step (3) concentration is 70% medicinal liquid.Step (2) gained TAISUIMUYE is mixed with step (3) gained medicinal liquid, shelved 52 hours.

Example 6, with example 1, different is: get 14 gram Cornu Cervi Pantotrichums, 19 gram Radix Codonopsis, 14 gram Caulis Spatholobis, 15 kairine sesames, the 26 gram Radixs Astragali, 14 gram Thelenota ananas (Jaeger), 24 gram Radix Polygoni Multiflori and soaked 18 hours.

Get 16 Keshan short, bristly hair or beards, 17 gram Semen Persicaes, 15 gram Margarita powder, 14 gram Cordyceps militaris (L.) Link., 20 gram Radix Rehmanniaes Preparata, 26 gram Fructus Mori, 16 gram Geckos, the 15 gram Rhizoma Anemarrhenaes, 15 gram Fructus Ligustri Lucidi, 13 gram Folium Ginkgos, 15 gram propolis, 16 gram Radix Puerariaes, 15 gram Fructus Hippophaes, 17 gram Poria, 20 gram Arillus Longans, 15 gram Fructus Rosae Laevigatae, 17 gram Semen Coiciss, 18 gram Pericarpium Citri Reticulataes, 16 gram Rhizoma Polygonati Odorati, 19 gram Folium Nelumbinis, 16 gram Cordyceps, 31 gram Fructus Lycii, 15 gram QUANGUI, 20 gram Trionyx sinensis (Wiegmann), 16 gram Radix Glycyrrhizaes, 14 gram dodder laurels, 18 gram Herba Cynomorii, 13 gram Rhizoma Polygonatis, the 14 Keshan Fructus Evodiaes, 15 gram Herba Epimedii, 19 gram Radix Panacis Quinquefoliis, 13 gram Colla cornus cervis, 18 gram Semen Cassiaes, 15 gram HUANGTAI, 15 gram Semen Vitis viniferae extracts, 14 gram Sucus Rosae Normalis, 50 gram Aloes, 40 gram Radix Angelicae Sinensis, 23 gram Radix Ginsengs, 39 gram Colla Corii Asini, 52 gram Foetus Caprae seu Ovis powder, 300 gram Ganodermas.The temperature that controls environment is 22-25 ℃, and humidity 35%--55% goes through fermentation in 6 months under sealing condition, step (2) concentration is 69% TAISUIMUYE, step (3) concentration is 72% medicinal liquid.Step (2) gained TAISUIMUYE is mixed with step (3) gained medicinal liquid, shelved 64 hours.

In June, 2008 to the 2009 year December outpatient service renal deficiency type chronic fatigue syndrome patient of Wuhan City XX hospital, patient's 203 examples of stable disease are divided into treatment at random and organize 118 examples, matched group 85 examples before being tried.Before the treatment state of an illness situation treatment group light, in, heavy type is 59,48,11, example deficiency of the kidney yin type, kidney yang deficiency syndrome, kidney yin and yang deficiency type are 75,12,31 examples, matched group is light, in, heavy type is 42,35,8 examples, deficiency of the kidney yin type, kidney yang deficiency syndrome, kidney yin and yang deficiency type are 53,10,22 examples.

The treatment group gives this preparation every day 2 times, each 10ml,

Matched group gives LIUWEI DIHUANG WAN (manufacturer: Henan Province Wanxi Pharmacy Stock Co., Ltd, product batch number: 080401, date of manufacture: 20080402, valid until 201303), and is oral, every day 3 times, each 8.

Comprehensive therapeutic effect the results are shown in Table 1:

Table 1

^＊p＜0.05， ^＊＊p＜0.01

Tcm syndrome relatively sees Table 2

Table 2

^＊p＜0.05， ^＊＊p＜0.01

Done hemorheological influence test, result of the test is: the whole blood contrast viscosity before and after the treatment of treatment group (low cutting), packed cell volume divide relatively, significant difference (p＜0.05), and this effect of matched group is not obvious, relatively, difference is remarkable (p＞0.05) not between two groups.Results suggest, this preparation have the effect of blood circulation promoting and blood stasis dispelling, blood viscosity lowering, and this effect of LIUWEI DIHUANG WAN is not obvious.

Done the influence test to blood fat, result of the test is: treat front and back serum TC, TG values relatively for two groups, and significant difference or highly significant (p＜0.05, p＜0.01), the serum hdl value compares significant difference (p＜0.05) before and after the treatment of treatment group.Show that this preparation has effect for reducing blood fat.

Done the safety evaluatio test, result of the test is: routine blood test, hepatic and renal function do not occur unusually before and after the treatment of treatment group, and blood pressure, heart rate do not have significant change before and after the treatment,

Conclusion: this preparation can obviously improve chronic fatigue syndrome patient suffer from a deficiency of the kidney symptom and sign, (P＜0.01); Efficacy evaluation: this preparation group is 84.75% to the comprehensive therapeutic effect total effective rate of fatigue syndrome, and light-duty, medium-sized, heavy total effective rate is respectively 93.22%, 79.17%, 63.64%; Total effective rate to deficiency of the kidney yin type, kidney yang deficiency syndrome, kidney yin sun amphitypy is respectively 89.33%, 88.89%, 85.71%; To soreness of the waist and knees, weak asthenia, meet that labor increases the weight of, total effective rate dizzy, headache is respectively 88.14%, 85.59%, 85.0%, 84.3%, 83.1%; Has blood fat reducing simultaneously, the effect of blood viscosity lowering.Wherein the improvement rate to each symptom of fatigue syndrome is higher than LIUWEI DIHUANG WAN, and the effect of blood fat reducing, blood viscosity lowering is better than LIUWEI DIHUANG WAN.At viewing duration, no obvious adverse reaction and adverse events take place.Show that this preparation can alleviate the nephropathy of chronic disease, improve renal function, alleviate the infringement of toxicant to kidney, promote the Excretion of kidney, remove the kidney toxin, human body immunity improving power is regulated the enhancing heart, liver, spleen, stomach, kidney, lung, large intestine, small intestinal, bladder, three warmers, cholic allomeric function.Promptly have clearing kidney toxicity, multiple deficient syndrome symptom can be alleviated or remove to the strong vital organs of the human body, strengthens the human body constitution function in delaying senility comprehensively.

Claims (2)

1. clearing kidney toxicity, the strong vital organs of the human body, the preparation of health invigorating slow down aging is characterized in that being made up of following components by weight proportion:

Cordyceps militaris (L.) Link. 13-16 gram Cornu Cervi Pantotrichum 14-17 gram Radix Codonopsis 19-22 gram

Caulis Spatholobi 12-16 gram Radix Rehmanniae Preparata 19-23 gram Fructus Mori 23-26 gram

Gecko 14-17 gram Rhizoma Anemarrhenae 12-16 gram Fructus Ligustri Lucidi 13-17 gram

Folium Ginkgo 13-16 gram Semen Vitis viniferae extract 13-17 gram Margarita powder 13-16 gram

Propolis 13-16 gram Radix Puerariae 14-17 gram Fructus Hippophae 12-16 gram

Poria 14-17 gram Arillus Longan 17-21 Keshan short, bristly hair or beard 12-16 gram

Fructus Rosae Laevigatae 12-16 gram Semen Coicis 12-17 gram Semen Persicae 13-17 gram

Pericarpium Citri Reticulatae 17-21 gram Rhizoma Polygonati Odorati 13-16 gram Folium Nelumbinis 18-21 gram

Ganoderma's 300 gram Aloe 48-52 gram Radix Angelicae Sinensis 38-41 grams

Radix Ginseng 23-26 gram Colla Corii Asini 38-41 gram Foetus Caprae seu Ovis powder 48-52 gram

Cordyceps 13-16 kairine sesame 14-16 gram Radix Astragali 23-26 gram

Fructus Lycii 28-31 gram QUANGUI 13-16 gram Trionyx sinensis (Wiegmann) 18-22 gram

Radix Polygoni Multiflori 23-26 gram Sucus Rosae Normalis 14-17 gram Radix Glycyrrhizae 14-16 gram

Dodder laurel 13-16 gram Herba Cynomorii 14-18 gram Rhizoma Polygonati 13-16 gram

Fructus Corni 12-16 gram Herba Epimedii 13-17 gram Radix Panacis Quinquefolii 18-21 gram

Colla cornus cervi 13-16 gram Semen Cassiae 18-21 gram Thelenota ananas (Jaeger) 13-16 gram

HUANGTAI 14-17 gram.

2. the described a kind of clearing kidney toxicity of claim 1, the strong vital organs of the human body, the preparation method of the preparation of health invigorating slow down aging is characterized in that concrete steps are as follows:

(1) 14-17 is restrained Cornu Cervi Pantotrichum, 19-22 gram Radix Codonopsis, 12-16 gram Caulis Spatholobi, 14-16 kairine sesame, the 23-26 gram Radix Astragali, 13-16 gram Thelenota ananas (Jaeger), 23-26 gram Radix Polygoni Multiflori and remove impurity, soaked 12-24 hour, clean, pick up, greatly only rive, midway trickle, run through, put in the food steamer, steamed foot 8 hours every day, stewing spending the night, stir up and down next morning 1 time, steam again, steam 4 days so repeatedly, stewing 4 nights, all be moist black to inside and outside, take out, shine to half-dried shave, the natural juice of gained is admixed in the time of will steaming, make it to exhaust drying, sieve dedust bits;

(2) with 12-16 Keshan short, bristly hair or beard, 13-17 restrains Semen Persicae, Herba Epimedii 13-17 restrains into a pot parching to brown, 13-16 gram Margarita powder adopts elutriation to grind, and 13-16 restrains Cordyceps militaris (L.) Link., 19-23 restrains Radix Rehmanniae Preparata, 23-26 restrains Fructus Mori, 14-17 restrains Gecko, 12-16 restrains the Rhizoma Anemarrhenae, 13-17 restrains Fructus Ligustri Lucidi, 13-16 restrains Folium Ginkgo, 13-16 restrains propolis, 14-17 restrains Radix Puerariae, 12-16 restrains Fructus Hippophae, 14-17 restrains Poria, 17-21 restrains Arillus Longan, 12-16 restrains Fructus Rosae Laevigatae, 12-17 restrains Semen Coicis, 17-21 restrains Pericarpium Citri Reticulatae, 13-16 restrains Rhizoma Polygonati Odorati, 18-21 restrains Folium Nelumbinis, 13-16 restrains Cordyceps, 28-31 restrains Fructus Lycii, 13-16 restrains QUANGUI, 18-22 restrains Trionyx sinensis (Wiegmann), 14-16 restrains Radix Glycyrrhizae, 13-16 restrains dodder laurel, 14-18 restrains Herba Cynomorii, 13-16 restrains Rhizoma Polygonati, the 12-16 Keshan Fructus Evodiae, 18-21 restrains Radix Panacis Quinquefolii, 13-16 restrains Colla cornus cervi, 18-21 restrains Semen Cassiae, the oven dry of 14-17 gram HUANGTAI, pulverize, mix;

Said mixture and step (1) gains are mixed, add 13-17 gram Semen Vitis viniferae extract again, 14-17 gram Sucus Rosae Normalis restrains Ganodermas with 300 and places fermentation tank, the mineral water that adds 3600 milliliters, slowly rotate clockwise, the temperature that controls environment is 20-26 ℃, and humidity 35%--65% goes through fermentation in 6-8 month under sealing condition, after filtration, remove slag, receive juice, obtain concentration and be 70 ± 2% TAISUIMUYE;

(3) 48-52 is restrained Aloe, 38-41 gram Radix Angelicae Sinensis, 23-26 gram Radix Ginseng, 38-41 gram Colla Corii Asini, 48-52 gram Foetus Caprae seu Ovis powder drying, pulverize, cross 100 mesh sieves with Universalpulverizer, causing blender mixes all, taking-up places extraction pot, add 800 ml concns and be 75% ethanol, soaked 2 hours, adopt the extraction of CO 2 fluid abstraction technique, filter, concentrate, obtain pale brown color medicinal liquid, through alkali treatment, cross macropore adsorption chromatography post, 95% ethanol elution, reclaim under reduced pressure concentrates, and obtaining concentration is 70 ± 2% medicinal liquids;

(4) be 1: 3 mixed by weight with step (2) gained TAISUIMUYE and step (3) gained medicinal liquid, shelved 48-72 hour, filter that sterilization gets preparation.