CN102293927A - Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof - Google Patents
Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation with antifatigue and antioxidation effects, and a preparation method thereof. The compound Chinese medicinal preparation is characterized by comprising the following components in part by weight: 2 to 10 parts of manyflower solomonseal rhizome, 3 to 10 parts of astragalus, 1 to 5 parts of American ginseng, 1 to 3 parts of lucid ganoderma, 0.5 to 1.5 parts of cordyceps sinensis, and 0.5 to 1.5 parts of cornu cervi pantotrichum. According to a formula, the medicines can be prepared into various formulations. Through the administration experiment of aging mice and crowd, compound Chinese medicinal preparation oral liquid can obviously improve the content of superoxide dismutase (SOD) and glutathione (GSH-Px) of an organism, has an effect of resisting and removing free radicals of the organism and delays the aging process; and by observing time of swimming with a load attached to the body of mice, SOD and the content of malondialdehyde (MDA), large and middle doses of the Chinese medicinal preparation can prolong the time of swimming with the load attached to the body of mice, improve the SOD activity of serum, and reduce MDA value, so that the compound Chinese medicinal preparation can enhance the antifatigue and antioxidation effects of mice by resisting free radicals.
Description
Technical field
The present invention relates to the herbal mixture field, specifically refer to a kind of Chinese traditional compound medicine and preparation method thereof with resisting fatigue and anti-oxidation function.
Background technology
With the quickening pace of modern life and other a variety of causes, many people's health is in " subhealth state " state.Be that health does not have organic disease, but functional change occurred, quality of life is poor, for example often feel tired, spirit is not good enough, muscle power " overdraw ", immunocompetence are low, easily catch a cold, symptoms such as naturally-aged acceleration are in the heart, cerebrovascular or other chronic disease in earlier stage.But all do not reach the clinical diagnosis level to all indexs of examination in hospital, this is " sub-health state " concrete manifestation in our life.Secular fatigue and human free radical increase multiple diseases such as may causing chronic fatigue syndrome, diabetes, hyperlipidemia, hypertension, tumor, cancer.Along with improving constantly of living standard, people more and more pay attention to health, change anosis prevention into from ill the seeing a doctor in past, to reach the purpose of the health that secures good health.Therefore the compound preparation of health food and medicine has the very big market demand.And sub-health state is because no tangible organic disease, therefore also do not have at present suitable medicine that it is prevented and treats.
Summary of the invention
Technical problem to be solved by this invention is that the present situation at prior art provides a kind of Chinese traditional compound medicine with resisting fatigue and anti-oxidation function, to reach the body constitution of improving people, the purpose of avoiding sub-health state.
Another technical problem to be solved by this invention provides a kind of preparation method with Chinese traditional compound medicine of resisting fatigue and anti-oxidation function.
The present invention solves the problems of the technologies described above the technical scheme that is adopted: this has the Chinese traditional compound medicine of resisting fatigue and anti-oxidation function, it is characterized in that comprising the following weight component:
Rhizoma Polygonati in the above-mentioned prescription is rhizome such as liliaceous plant Rhizoma Polygonati, capsule silk Rhizoma Polygonati, hot river Rhizoma Polygonati, Yunnan Rhizoma Polygonati, polygonatum cirrhifolium Royle.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, the function of kidney tonifying.Cure mainly weakness of the spleen and stomach, fatigue and asthenia, the xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat disease such as quench one's thirst is simultaneously very effective in cure for diabetes.
The Radix Astragali has the effect of invigorating QI to consolidate the body surface resistance, diuresis, and among the people also have the winter to get the custom that the Radix Astragali is made into the food of nourishing and fit keeping function.Be " key medicine of QI invigorating is mended all empty not enough " from ancient times.It has good scavenging action to multiple free radical, can prevent biomembranous lipid peroxidation.
Radix Panacis Quinquefolii is a medicinal and edible plant, is famous and precious top grade Chinese medicine, is again the high-grade nourishing good merchantable brand.Have anticancer, resisting fatigue, anti-hypoxia, radioprotective, the anti-ageing multiple function of waiting for a long time, coronary heart disease, hypertension, anemia, neurosis, diabetes etc. are had good curative effect.Often take Radix Panacis Quinquefolii, but building body, life lengthening.
Ganoderma is called as " Herba mesonae chinensis ", goes into the five internal organs, and the gas of completion body is so a little less than the heart, lung, liver,spleen,kidney deficiency of five ZANG-organs, all can obey it.Has strengthening the body resistance, raise immunity, the huge effect that improves Abwehrkraft des Koepers.Effect with antitumor, anticancer, defying age, antiallergic, treatment hypertension, diabetes, beauty treatment.
Cordyceps has the effect of " reason weakness ", and effect and Radix Ginseng are similar, can control weakness, with its gas that gets negative and positive entirely also.Property of medicine gentleness, old and young sick empty person all should eat.
Cornu Cervi Pantotrichum is good at kidney invigorating and YANG supporting, and spermatogenesis benefit blood is mended the strong bone of marrow.The Cornu Cervi Pantotrichum property of medicine is temperature partially, and is can tonifying YANG but not dry, and companion's Yin-nourishing prescription usefulness then can yin nourishing and oiliness, takes so be well suited for the old people.For the degenerative disease of skeletal system, and the function of other internal organs weakens gradually and many morbid state occurs, breathes heavily as frequent urination at night and sexual impotence erectile problem, failure of the kidney in receiving QI, the not good key of kidney and ear tinnitus of deficiency type, even becomes deaf etc. certain curative effect is all arranged!
This Chinese traditional compound medicine is a principal agent with Rhizoma Polygonati, the Radix Astragali, Radix Panacis Quinquefolii, be aided with Ganoderma, Cordyceps and Cornu Cervi Pantotrichum, from Chinese medicine health preserving essence, gas, refreshing three aspect nourishing kidney replenishing essences, invigorating QI to consolidate the body surface resistance, nourishing blood to tranquillize the mind, from the human body five elements start with tranquilizing by nourishing the heart, kidney tonifying, essence replenishing, strong board appetizing, lung moistening YIN nourishing, hemopoietic nourishing the liver, thereby reach YIN and YANG balancing, the five internal organs with mending enhancing immunity, resisting fatigue and antioxidative effect.
Above-mentioned preparation method with Chinese traditional compound medicine of resisting fatigue and anti-oxidation function is characterized in that comprising the steps:
1) takes by weighing described Rhizoma Polygonati, the Radix Astragali, Radix Panacis Quinquefolii, Ganoderma, Cordyceps and Cornu Cervi Pantotrichum in proportion, join in the water of 8-12 times of above-mentioned substance gross weight and decocted 1-3 hour, filter, obtain filtrate and filtering residue for the first time;
2) in described filtering residue, add 6-10 once more and doubly boiled 0.5-1.5 hour, filter, obtain filtrate for the second time to the decocting of filtering residue weight;
3) merge for the first time filtrate and for the second time filtrate obtain filtrate;
4) be mixed with oral liquid, concrete steps are as follows:
After being concentrated into relative density 1.05-1.15 behind the described filtrate high speed centrifugation, adding purified water, flavoring agent are mixed with oral liquid; Described flavoring agent is selected oligosaccharide syrup, white sugar or sweeting agent etc. usually for use; The consumption of purified water and flavoring agent consumption use routinely gets final product; Described relative density is that the density with water is reference;
Perhaps make granule, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; Add the granule adjuvant then and do soft material in extractum, make the wet granular oven dry, fill becomes granule;
Wherein, described adjuvant is flavoring agent and magnesium stearate; Described flavoring agent can be Icing Sugar, maltodextrin, glucose and/or sweeting agent etc.; The addition of adjuvant consumption routinely gets final product;
Perhaps be mixed with pill, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; In extractum, add the pill adjuvant, make soft material; Make wet ball with pellet processing machine then, oven dry, coating is packaged into pill;
The part by weight of described extractum and adjuvant is 1: 2～4, and wherein said adjuvant is starch, maltodextrin and/or microcrystalline Cellulose;
Perhaps be mixed with capsule, tablet or soft capsule, concrete steps are as follows:
With the centrifugal relative density 1.2～1.4 that is concentrated into of described filtrate, pulverize behind the vacuum drying, add adjuvant and make tablet or capsule; Wherein prepare the used adjuvant of tablet and be selected from lactose, microcrystalline Cellulose, starch, dextrin and/or magnesium stearate etc., the used adjuvant of preparation soft capsule can be selected vegetable oil and Cera Flava etc. for use.
Chinese traditional compound medicine oral liquid provided by the present invention, by to significantly improving body superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) content through mouse aging and crowd are taken evidence, have opposing and remove the effect of body free radical, slow down aging process; Observe mice swimming with a load attached to the body time, serum superoxide dismutases (SOD), malonaldehyde (MDA) content value, the result proves that the big or middle dosage of this product can prolong the mice swimming with a load attached to the body time, activity of SOD in serum is increased, the MDA value descends, and illustrates that this product can strengthen the mouse anti-reflecting fatigue effect by free radical resisting.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment 1
Rhizoma Polygonati 4.0kg, Radix Astragali 10.0kg, Radix Panacis Quinquefolii 5.0kg, Ganoderma 3.0kg, Cordyceps 1.5kg, Cornu Cervi Pantotrichum 1.5kg adds water 250kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
In filtering residue, add water 200kg and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
To be concentrated into 20L behind the filtrate high speed centrifugation, the oligosaccharide syrup 25kg of Jia Ruing, potassium sorbate 0.165kg, purified water 5kg are mixed with oral liquid 50L then, and boiling sterilization 30 minutes is up to the standards, and fill obtains 1000 of oral liquids.
Its mouse oral gives this product oral liquid 30d, adopts the swimming with a load attached to the body experiment, observes the mice swimming death time; Blood sampling detects the serum urea nitrogen content behind the swimming certain hour; Getting liver detects hepatic glycogen content and measures the variation of mice at motion and quiet front and back blood lactic acid content.The result shows that the mice swimming with a load attached to the body time obviously prolongs, and the serum urea nitrogen content that produces during motion reduces, and hepatic glycogen content increases, and the elimination value that motion finishes quiet 20min bleeding from anus lactic acid increases, and weight of mice is not had influence.Presentation of results this product has the effect of alleviating the mice physical fatigue.
Embodiment 2
Rhizoma Polygonati 6kg, Radix Astragali 3kg, Radix Panacis Quinquefolii 1.0kg, Ganoderma 1.0kg, Cordyceps 1.0kg, Cornu Cervi Pantotrichum 0.8kg adds water 128kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 10.2kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density about 1.3, adds Icing Sugar 5.7g and make soft material, after 14 eye mesh screens filter, waving in the granulation machine and making granule,, after the arrangement of 14 eye mesh screens, add 25g silicon dioxide, make 2000 bags of granules then 60 ℃ of oven dry.
Embodiment 3
Rhizoma Polygonati 6.0kg, Radix Astragali 6.0kg, Radix Panacis Quinquefolii 1.0kg, Ganoderma 1.0kg, Cordyceps 0.5kg, Cornu Cervi Pantotrichum 1.0kg adds water 155kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 124kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density about 1.3, adds starch 9.3kg and make soft material, make wet ball with pellet processing machine, 65 ℃ of oven dry, dried ball coating, packing is made 100000 of pills.
Embodiment 4
Rhizoma Polygonati 4.0kg, Radix Astragali 4.0kg, Radix Panacis Quinquefolii 1.2kg, Ganoderma 1.2kg, Cordyceps 0.5kg, Cornu Cervi Pantotrichum 0.5kg adds water 114kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 91.2kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.27, vacuum-0.008Mpa, 80 ℃ of dryings, pulverize at low temperature adds lactose 1.2kg, medicinal alcohol 0.5kg makes soft material, and 14 eye mesh screens are made wet granular, 60 ℃ of oven dry, 14 mesh sieve granulate, add the 30g magnesium stearate, mixing, tabletting is made 20000 in tablet.
Adopt the nape subcutaneous injection D-of portion galactose to set up aging model, give mouse stomach 30d with this product tablet continuously with 2.0g/k gd and 4.0g/kgd, and irritate stomach with normal saline and do the blank group.This product tablet can significantly improve the activity (P＜0.01) that D-galactose D-causes superoxide dismutase in the mouse aging serum (SOD) as a result, significantly reduces the activity (P＜0.01) of malonaldehyde (MDA), and can improve the activity of glutathion (PSH-PX).Presentation of results this product is set up mouse aging to the D-galactose better antioxidation.
Embodiment 5
Rhizoma Polygonati 5.0kg, Radix Astragali 4.0kg, 1.0 parts of Radix Panacis Quinquefoliis, 1.0 parts of Ganodermas, 0.8 part of Cordyceps, 0.8 part in Cornu Cervi Pantotrichum adds water 126kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 100.8kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.27, vacuum-0.008Mpa, 80 ℃ of dryings, pulverize at low temperature, add starch 1.7kg, medicinal alcohol 0.56kg makes soft material, and 14 eye mesh screens are made wet granular, 60 ℃ of oven dry, 14 mesh sieve granulate add the 30g magnesium stearate, mixing, capsule charge is made 20000 of capsules.
Embodiment 6
Rhizoma Polygonati 5.0kg, Radix Astragali 3.0kg, Radix Panacis Quinquefolii 1.5kg, Ganoderma 1.0kg, Cordyceps 0.5kg, Cornu Cervi Pantotrichum 0.5kg adds water 115kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 92kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.28, vacuum-0.008Mpa, 80 ℃ of dryings, pulverize at low temperature is crossed 100 mesh sieves, and the 0.3kg Cera Flava is added an amount of vegetable oil, heating and melting, add residue vegetable oil mix homogeneously, vegetable oil is 4.7kg altogether, after oily wax mixture temperature drops to below 40 ℃, extract powder is added in the above-mentioned oily wax mixture, mix homogeneously, cross 100 mesh sieves, leave standstill 30 minutes de-bubbled, 10000 of soft capsules are made in fill.
Claims (2)
1. Chinese traditional compound medicine with resisting fatigue and anti-oxidation function is characterized in that comprising the following weight component:
2. the preparation method with Chinese traditional compound medicine of resisting fatigue and anti-oxidation function as claimed in claim 1 is characterized in that comprising the steps:
1) takes by weighing described Rhizoma Polygonati, the Radix Astragali, Radix Panacis Quinquefolii, Ganoderma, Cordyceps and Cornu Cervi Pantotrichum in proportion, join in the water of 8-12 times of above-mentioned substance gross weight and decocted 1-3 hour, filter, obtain filtrate and filtering residue for the first time;
2) in described filtering residue, add 6-10 once more and doubly boiled 0.5-1.5 hour, filter, obtain filtrate for the second time to the decocting of filtering residue weight;
3) merge for the first time filtrate and for the second time filtrate obtain filtrate;
4) be mixed with oral liquid, concrete steps are as follows:
After described filtrate high speed centrifugation is concentrated into relative density 1.05-1.15, adds purified water and/or flavoring agent and be mixed with oral liquid;
Perhaps make granule, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; Add the granule adjuvant then and do soft material in extractum, make the wet granular oven dry, fill becomes granule;
Perhaps be mixed with pill, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; In extractum, add the pill adjuvant, make soft material; Make wet ball with pellet processing machine then, oven dry, coating is packaged into pill;
The part by weight of described extractum and adjuvant is 1: 2～4, and wherein said adjuvant is selected from starch, maltodextrin and/or microcrystalline Cellulose, and the addition of each material consumption use routinely gets final product;
Perhaps be mixed with capsule, tablet or soft capsule, concrete steps are as follows:
With the centrifugal relative density 1.2～1.4 that is concentrated into of described filtrate, pulverize behind the vacuum drying, add capsule, additive of tablet, make capsule, tablet; Or adding soft capsule adjuvant is made soft capsule.Wherein, described capsule, tablet dressing can be lactose, microcrystalline Cellulose, starch, dextrin and/or magnesium stearate etc., and described soft capsule adjuvant can be materials such as vegetable oil and Cera Flava.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211219A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food for relieving physical fatigue and preparation method thereof |
| CN104857046A (en) * | 2014-02-20 | 2015-08-26 | 吉林大清鹿苑保健科技有限公司 | Panax quinquefolius-hairy antler particles and preparation method thereof |
| CN106138715A (en) * | 2016-09-27 | 2016-11-23 | 杭州本草养正堂生物科技有限公司 | A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue |
| CN106266573A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of resisting fatigue, the compound preparation and preparation method thereof of defying age |
| CN106309910A (en) * | 2016-04-09 | 2017-01-11 | 王书德 | Cordyceps sinensis kidney pancreas pill |
| CN107744564A (en) * | 2016-08-10 | 2018-03-02 | 杨丛刚 | A kind of benefiting qi and nourishing blood, the antler health-care product of strengthen immunity and preparation technology |
| CN108175825A (en) * | 2017-01-25 | 2018-06-19 | 青海春天药用资源科技利用有限公司 | For tonifying Qi of the kidney, pharmaceutical composition of invigorating the spleen moistening lung and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101804165A (en) * | 2010-04-16 | 2010-08-18 | 武汉枫叶红生物科技有限公司 | Preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and preparation method thereof |
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2011
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804165A (en) * | 2010-04-16 | 2010-08-18 | 武汉枫叶红生物科技有限公司 | Preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211219A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food for relieving physical fatigue and preparation method thereof |
| CN103211219B (en) * | 2013-04-25 | 2014-08-20 | 福建永生活力生物工程有限公司 | Health food for relieving physical fatigue and preparation method thereof |
| CN104857046A (en) * | 2014-02-20 | 2015-08-26 | 吉林大清鹿苑保健科技有限公司 | Panax quinquefolius-hairy antler particles and preparation method thereof |
| CN106309910A (en) * | 2016-04-09 | 2017-01-11 | 王书德 | Cordyceps sinensis kidney pancreas pill |
| CN107744564A (en) * | 2016-08-10 | 2018-03-02 | 杨丛刚 | A kind of benefiting qi and nourishing blood, the antler health-care product of strengthen immunity and preparation technology |
| CN106138715A (en) * | 2016-09-27 | 2016-11-23 | 杭州本草养正堂生物科技有限公司 | A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue |
| CN106266573A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of resisting fatigue, the compound preparation and preparation method thereof of defying age |
| CN108175825A (en) * | 2017-01-25 | 2018-06-19 | 青海春天药用资源科技利用有限公司 | For tonifying Qi of the kidney, pharmaceutical composition of invigorating the spleen moistening lung and preparation method thereof |
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