CN106138715A - A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue - Google Patents
A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue Download PDFInfo
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- CN106138715A CN106138715A CN201610856830.3A CN201610856830A CN106138715A CN 106138715 A CN106138715 A CN 106138715A CN 201610856830 A CN201610856830 A CN 201610856830A CN 106138715 A CN106138715 A CN 106138715A
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- 239000011669 selenium Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 231100001265 toxicological assessment Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses compound preparation of a kind of defying age, resisting fatigue and preparation method thereof, specifically, this compound preparation is made up of adjuvant by weight and following Chinese medicinal components: 25 35 parts of Radixs Astragali, 25 35 portions of Ganodermas, 13 17 parts of Rhizoma Polygonatis, 13 17 parts of Fructus Lycii, 8 12 parts of Radix Panacis Quinquefoliis, 57 portions of Radix Notoginseng and 6 10 parts of Hirsutella hepiali Chen et Shen filaments.The method preparing this compound preparation, comprises the following steps: 1) Radix Panacis Quinquefolii and Radix Notoginseng are pulverized；2) Radix Astragali, Ganoderma, Rhizoma Polygonati, Fructus Lycii are carried out water and carry, cream drying and crushing processed；3) adjuvant preparation is added.The free radical that this compound preparation can produce in purged body effectively, promotes immunity and the metabolism of body inner cell, has the effect of preferable defying age, resisting fatigue.This compound preparation is through inspection, and active component is high, have no side effect.
Description
Technical field
The present invention relates to Chinese medicine compound field, be specifically related to a kind of defying age, the compound preparation of resisting fatigue and preparation side thereof
Method.
Background technology
" gas " of the traditional Chinese medical science is relevant with human defense's function, if " gas " is abundant, function perfects, and resistance against diseases is the strongest.
Vital essence, the vital essence of spleen transporting and transforming nutrients from foodstuff that " gas " of the traditional Chinese medical science is sucked by lung form, with immune relationship with the congenital essence three part of kidney
The closest is " kidney ", " the kidney being the origin of congenital constitution ", kidney controlling essence storage, improving inspiration by invigorating kidney-QI.Modern medicine study think the traditional Chinese medical science " kidney " with interior point
Secrete function and have substantial connection, thalamus pituitary adrenal cortical reaction hypofunction in the presence of the patient that suffers from a deficiency of the kidney, cellular immunization with
The problems such as humoral immune function reduces, and microcirculatory perfusion is not enough.The traditional Chinese medical science thinks " kidney governing bones ", " the raw marrow of bone ", kidney and immunocompetence
Hemapoiesis is relevant.Immunologic function after patient's the kidney invigorating of suffering from a deficiency of the kidney can be improved.Lung governing qi, whether lung qi abundance defends with human immunity
Effect is strong and weak relevant.The traditional Chinese medical science thinks that " lung governing skin and hair ", lung qi the most then space between skin and muscles are consolidated the closeest, and exopathogen is difficult to invade, insufficiency of lung-QI then people
Body defense function weakens, and exopathogen is easily invaded, modern medicine study, finds that insufficiency of lung-QI patient's immunologic function reduces.Spleen, the main fortune of spleen
Change, for the foundation of acquired constitution, source of generating QI and blood.The power of human righteousness, depends on the keeping of taste, temper healthy and vigorous.The merit of spleen
Can be normal, it is that body is able to key factor that is the most steady and that possess defence capability.
The aging of cell is closely related with apoptosis.Think in the industry at present, cause apoptotic main extraneous factor
May be free radical, free radical be attacked biomembrane, polyunsaturated fatty acid, DNA, protein and other biological macromole and is caused
Oxidative damage be to cause organism aging process and the principal element of many senile disease.Main free radical in human body is hydroxyl radical free radical
And ultra-oxygen anion free radical.
Along with the development of society, people's rhythm of life is accelerated, and job market competition is the fiercest, and health is chronically at spirit
Tense situation, chronic fatigue syndrome also threatens the health of people.Fatigue is a sufficiently complex physiological and pathological phenomenon, and
Affected by various factors.Tired allomeric function state changes, and depends on the common regulation of the five internal organs, in physical tiredness state
Middle liver occupy core status；Under spirituality fatigue state, attach most importance to the heart；Under the chronic consumptive disease state of chronic fatigue syndrome, with
Spleen kidney is crucial, also depends on the coordination of conscience and lung.
Chinese medicine includes removing free radical, increasing glycogen deposit, regulation testosterone and cortex in terms of antifatigue effect mechanism
Alcohol level, reduce motion after the level of metabolite, the regulation Transmitters such as maincenter 5-HT, DA and regulate intracellular relevant enzyme
Level.
Chinese herbal preparations can improve the activity of body antioxidase, prevents the Radical Metabolism caused by motion to strengthen, and protects
Protect histiocyte and there is certain antifatigue effect.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention aims to provide the compound recipe of a kind of defying age, resisting fatigue
Preparation.
The purpose of the present invention realizes by the following technical solutions:
A kind of defying age, the compound preparation of resisting fatigue, be made up of adjuvant by weight and following Chinese medicinal components:
Preferably, this compound preparation is made up of adjuvant by weight and following Chinese medicinal components:
Preferably, this compound preparation is made up of adjuvant by weight and following Chinese medicinal components:
Preferably, adjuvant described in this compound preparation is magnesium stearate.
Preferably, the weight portion of described adjuvant is 0.1-0.5 part.
The method that another object of the present invention is to the compound preparation providing preparation to state, comprises the following steps:
1) pulverize: the Radix Panacis Quinquefolii and the Radix Notoginseng that take formula ratio are pulverized；
2) water carries: take the Radix Astragali of formula ratio, Ganoderma, Rhizoma Polygonati, Fructus Lycii, boiling, takes extracting solution, and concentrating under reduced pressure must soak
Cream, vacuum drying, pulverize；
3) preparation: by step 1) pulverize after material and step 2) pulverize after material, add adjuvant mix homogeneously, packaging.
Preferably, step 2) in, adding water volume is after mixing 8-12 times of material cumulative volume, decocts 2 times, when decocting every time
Between be 2-3 hour.
Step 2) in, the pressure of concentrating under reduced pressure is 0.06-0.08Mpa, and temperature is 70-80 DEG C.
Preferably, step 2) in, being concentrated into relative density is 1.25-1.30.
Preferably, step 3) in, described adjuvant is magnesium stearate, fills capsulation.
The defying age of this formula offer, the compound preparation of resisting fatigue, from strengthening the body resistance, regulation function is started with, comprehensively
Adjust body function, dredge mechanism of qi, make negative and positive of qi and blood tend to normal and balance.In side, the Radix Astragali returns lung, spleen channel, function QI invigorating
Yang invigorating, strengthening superficial resistance to stop perspiration, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation；Ganoderma GUIXIN, lung, liver, kidney channel, completion body QI of five ZANG-organs, strengthening the body resistance；
Rhizoma Polygonati enters spleen, kidney, lung meridian, has boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying；Fructus Lycii returns liver, kidney channel, nourishing the liver and kidney,
Replenishing vital essence to improve eyesight, can be remarkably reinforced the immune function of body；Radix Panacis Quinquefolii GUIXIN, lung, kidney channel, function boosting qi and nourishing yin, clearing away heat and promoting production of body fluid；Bat
Bat is by hair spore mycelium invigorating the lung and the kidney；Radix Notoginseng returns liver, stomach, the heart and small intestine meridian, function hemostasis, dissipating blood stasis, detumescence, pain relieving, qi-restoratives.
Many medicines phases 5, spleen invigorating lung moistening, liver nourishing kidney tonifying, benefit essence is filled out marrow, boosting qi and nourishing yin, strengthening the body resistance, is improved the mental energy of people, the most anti-
Old and feeble, resisting fatigue.
In the present invention, astragalus polysaccharides, ganoderan, polygonatum polysaccharide, Lycium barbarum polysaccharides, Radix Panacis Quinquefolii total sugar, Radix Panacis Quinquefolii saponin,
Arasaponin can significantly improve cytophagous phagocytic function, improves the multiplication capacity of lymphocyte, and the cell improving body is lived
Power, promote the cell of body newly except metaboilic level, thus effectively defying age, resisting fatigue.
Lycium barbarum polysaccharide can dramatically increase Mouse Muscle glycogen, liver glycogen reserves amount, improves blood lactic acid dehydrogenase before and after motion
Total activity；Reduce blood urea nitrogen increments after mice strenuous exercise, the clearance rate of blood urea nitrogen after accelerating to move.This shows Chinese holly
Qi polysaccharide has fairly obvious effect to allaying tiredness.Fructus Lycii is rich in total flavonoids of lycium barbarum L and lycium barbarum polysaccharide, and wherein Fructus Lycii is many
Sugar is a kind of water soluble polysaccharide, by arabinose, glucose, galactose, mannose, xylose, these 6 kinds of monosaccharide components groups of rhamnose
Become, there is physiologically active, it is possible to enhancing non-specific immunity function, improve resistance against diseases.Lycium barbarum polysaccharide can release mice fortune
Dynamic property Skeletal Muscle Fatigue, after retardation motion, muscle glycogen content significantly reduces.
The chemical composition of the former plant of Radix Notoginseng is more, mainly by tetracyclic triterpene dammarane type protopanoxadiol saponins and Fourth Ring
Triterpene dammarane type Protopanaxatriol's saponins forms, and has heart tonifying, coronary artery dilator, increase coronary blood to cardio-cerebrovascular
Flow, reduction surface activity of blood platelet, the suppression effect such as platelet adhesion reaction and gathering, reduction blood viscosity, antithrombotic, to cerebrovascular
Hypoxic-ischemic damage, cerebral ischemia, the protected effect of reperfusion injury, have inhibitory action to cranial nerve cell apoptosis.
Hirsutella hepiali Chen et Shen filament (Hirsutella hepiali Chen et Shen) is to separate from natural cs
The cordyceps species that purification obtains, utilizes the artificial aweto that modern biological project fermentation technique is produced.Mortierella hepiali mycelia
Body polysaccharide can substantially suppress H22 hepatocarcinoma, and regulates humoral immunity of organism function, promotes the phagocytic activity of macrophage.
This defying age, resisting fatigue formula are started with from strengthening the body resistance, regulation function, overall regulation of body function,
Dredge mechanism of qi, make negative and positive of qi and blood tend to normal and balance.Many medicine compatibilities, spleen invigorating lung moistening, liver nourishing kidney tonifying, benefit essence fills out marrow, and QI invigorating is supported
The moon, strengthening the body resistance, the free radical in the regulation metabolic balance of body, purged body, the metabolic activity of enhancing cell, defying age resists tired
Labor.
Compared to existing technology, the beneficial effects of the present invention is:
Defying age that the present invention provides, the compound preparation of resisting fatigue, its free radical that can effectively produce in purged body, promote
Enter immunity and the metabolism of body inner cell, there is the effect of preferable defying age, resisting fatigue.This compound preparation is through inspection, activity
Composition is high, have no side effect.
Detailed description of the invention
Below, in conjunction with detailed description of the invention, the present invention is described further:
The present invention provides the compound preparation of a kind of defying age, resisting fatigue, by adjuvant by weight and following Chinese drug-treated group
Divide and make:
In this compound preparation, the Radix Astragali contains multiple saponin, flavone, polysaccharide, and aminoacid, linoleic acid, alkaloid etc. are multiple
Miscellaneous chemical composition, wherein the compound such as astragalus polysaccharides, saponin, flavone has stronger biological activity.Ganoderma contain polysaccharide, three
150 multiple compounds such as terpene, protein, polypeptide, aminoacid, steroid and various trace element, wherein ganoderan can improve little
Non-specific and the specific cellular immunity function of Mus.The metabolic activity of enhancing body.Rhizoma Polygonati contains sibiricoside, nicotinic acid, sugar
Class, quinones, aminoacid and trace element.Fructus Lycii contains lycium barbarum polysaccharide, aminoacid, carotene, vitamin E, phylloxanthin, multiple
The Multiple components such as trace element (such as zinc, copper, selenium etc.).The chemical composition of Radix Panacis Quinquefolii be mainly monosaccharide, polysaccharide, saponin, aminoacid,
Protein, enzyme, organic acid and trace element etc..Radix Notoginseng main component has Radix Notoginseng total arasaponins, dencichine, flavone, volatile oil, ammonia
Base acid, saccharide and various trace element etc..Hirsutella hepiali Chen et Shen filament main component have adenosine, uridnine, urine purine, guanosine,
Mannitol, ergosterol, polysaccharide etc..
Raw material employed in the present invention all can obtain by the way of commercially available.In detailed description below, all in
Medicine component all meets the Pharmacopoeia of the People's Republic of China one middle respective standard requirement of version in 2010, is purchased from Hebei Qi Xin Chinese medicine
Granule pieces company limited.Magnesium stearate meets the Pharmacopoeia of the People's Republic of China two middle respective standard requirements of version in 2010,
Purchased from Huzhou Zhanwang Pharmaceutical Co., Ltd..
Embodiment 1
A kind of defying age, the compound preparation of resisting fatigue, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 4kg Radix Panacis Quinquefolii and 2.4kg Radix Notoginseng is pulverized；
2) water carries: takes the 12kg Radix Astragali, 12kg Ganoderma, 6kg Rhizoma Polygonati, the mixing of 6kg Fructus Lycii, adds 5 times of volumes of mixed material
Water decoct, decoct after 2h, take extracting solution, add the water of 5 times of volumes and again decoct 2h, united extraction liquid, 70-80 DEG C
It is concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtains extractum, vacuum drying, pulverize,
15.78kg fine powder；
3) preparation: by step 1) pulverize after material and step 2) fine powder that obtains, add the mixing of 0.08kg magnesium stearate, mixed
Close uniformly, fill capsulation.
Embodiment 2
A kind of defying age, the compound preparation of resisting fatigue, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 4.4kg Radix Panacis Quinquefolii and 2.8kg Radix Notoginseng is pulverized；
2) water carries: takes the 10kg Radix Astragali, 14kg Ganoderma, 5.2kg Rhizoma Polygonati, the mixing of 6.8kg Fructus Lycii, adds mixed material 4 times
The water of volume decocts, and after decocting 2h, takes extracting solution, and the water adding 4 times of volumes decocts 2h, united extraction liquid, 70-again
80 DEG C are concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtain extractum, vacuum drying, powder
Broken, obtain 15.94kg fine powder；
3) preparation: by step 1) pulverize after material and step 2) fine powder that obtains, add the mixing of 0.08kg magnesium stearate, mixed
Close uniformly, fill capsulation.
Embodiment 3
A kind of defying age, the compound preparation of resisting fatigue, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 3.6kg Radix Panacis Quinquefolii and 2kg Radix Notoginseng is pulverized；
2) water carries: takes the 14kg Radix Astragali, 10kg Ganoderma, 6.8kg Rhizoma Polygonati, the mixing of 5.2kg Fructus Lycii, adds mixed material 4 times
The water of volume decocts, and after decocting 2h, takes extracting solution, and the water adding 4 times of volumes decocts 2h, united extraction liquid, 70-again
80 DEG C are concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtain extractum, vacuum drying, powder
Broken, obtain 15.66kg fine powder；
3) preparation: by step 1) pulverize after material and step 2) fine powder that obtains, add the mixing of 0.08kg magnesium stearate, mixed
Close uniformly, fill capsulation.
Comparative example 1:
A kind of defying age, the compound preparation of resisting fatigue, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) pulverize: take 3.6kg Radix Panacis Quinquefolii；
2) water carries: takes the 14kg Radix Astragali, 10kg Ganoderma, 6.8kg Rhizoma Polygonati, 5.2kg Fructus Lycii and 2kg Radix Notoginseng and is pulverized and mixed, adds
The water entering 4 times of volumes of mixed material decocts, and after decocting 2h, takes extracting solution, and the water adding 4 times of volumes decocts 2h again,
United extraction liquid, 70-80 DEG C is concentrated into mastic relative density as 1.25-1.30 with the pressure of 0.06-0.08Mpa, obtains leaching
Cream, vacuum drying, pulverize, obtain 16.09kg fine powder；
3) preparation: by step 1) pulverize after material and step 2) fine powder that obtains, add the mixing of 0.08kg magnesium stearate, mixed
Close uniformly, fill capsulation.
Comparative example 2:
A kind of defying age, the compound preparation of resisting fatigue, be made up of following components by weight:
The method preparing this compound preparation, comprises the following steps:
1) water carries: take the 14kg Radix Astragali, 10kg Ganoderma, 6.8kg Rhizoma Polygonati, 5.2kg Fructus Lycii, 3.6kg Radix Panacis Quinquefolii, 2kg Radix Notoginseng
Being pulverized and mixed, the water adding 4 times of volumes of mixed material decocts, and after decocting 2h, takes extracting solution, adds the water of 4 times of volumes
Again decocting 2h, united extraction liquid, 70-80 DEG C is concentrated into mastic relative density with the pressure of 0.06-0.08Mpa and is
1.25-1.30, obtains extractum, vacuum drying, pulverizes, obtains 16.31kg fine powder；
2) preparation: by step 1) pulverize after the fine powder that obtains, add the mixing of 0.08kg magnesium stearate, mix homogeneously, fill glue
Capsule is packed.
The compound preparation that embodiment 1-3 and comparative example 1-2 obtain is capsule, and its content is powder, content face
Color is brown, is visible by naked eyes impurity.Its dosage form is capsule, and preparation packing specification is 0.4g/ grain, it is recommended that day dose 6
Grain, i.e. every day 2 times, each 3.
Detection embodiment
1. functional component inspection
By Ministry of Public Health " health food detection and assessment technique specification " 2003, embodiment 1-3 and comparative example 1-2 are obtained
To compound preparation carry out total saponins, crude polysaccharides detection, its result is as shown in the table:
Table 1 functional component is checked
As shown in Table 1, embodiment 1-3 obtains its total saponins of compound preparation and crude polysaccharides content the most relatively comparative example 1 and 2
Height, and comparative example 1 the most relatively comparative example 2 is high, say, that Radix Panacis Quinquefolii and Radix Notoginseng are directly pulverized, and other Chinese medicinal components uses water
The mode of extraction, contributes to the abundant release of effective ingredient.
2. physicochemical property detection
By the requirement of GB16740-1997, the compound preparation obtaining embodiment 1-3 and comparative example 1-2 carries out a huge sum of money
The physicochemical property detection of genus, moisture, ash and disintegration time, its result is as shown in the table.
Table 2 compound preparation physical and chemical index detects
As shown in Table 2, the physicochemical property of the compound preparation that embodiment 1-3 and comparative example 1-2 obtain is satisfied by GB16740-
The requirement of 1997.
3. sanitary microorganism detection
By the requirement of GB16740-1997, it is total that the compound preparation obtaining embodiment 1-3 and comparative example 1-2 carries out bacterium colony
Number, coliform group count, mycete, yeast, gold-coloured staphylococci, Salmonella, shigella, Hemolytic streptococcus health micro-
Biological detection, its result is as shown in the table.
Table 3 sanitary microorganism detects
As shown in Table 3, the sanitary microorganism index of the compound preparation that embodiment 1-3 and comparative example 1-2 obtain is satisfied by
The requirement of GB16740-1997.
4. Toxicological evaluation
The compound preparation obtaining embodiment 1-3 and comparative example 1-2 carries out acute oral toxicity test, genetoxic examination
Test, 30 days feeding trials of rat, its result is as shown in the table:
Table 4 safety Toxicological Assessment
As seen from the above table, the compound preparation that embodiment 1-3 and comparative example 1-2 obtain all belongs to non-toxic type, to mice without causing
Mutability, 30 days feeding trials of rat maximum without agent is human body recommended amounts 100 times.
5. immune effect test
According to Ministry of Public Health " health food inspection and assessment technique specification ", the compound preparation that embodiment 1 obtains is glue
Capsule, gives 0.4g/kg.bw, 0.8g/kg.bw and 1.2g/kg.bw dosage to mice (Balb/c), carries out 30 days tardy respectively
Allergic reaction type test (DTH), antibody-producting cell, lymphocyte transformation test (MTT), serolysin test and NK cell
Determination of activity, with aquesterilisa gavage as matched group.
Compound preparation is as shown in the table on the impact of Mouse Weight:
The impact on Mouse Weight of table 5 compound preparation
0.4g/kg.bw, 0.8g/kg.bw with 1.2g/kg.bw dosage group compared with matched group, the body weight gains of mice, spleen
Dirty/body weight ratio, thymus/body weight ratio there are no significant difference (P > 0.05).
Table 6 delayed allergy is tested
In delayed allergy is tested, 1.2g/kg.bw dosage group is compared with matched group, and its swelling degree of the paw has aobvious
Write difference (P < 0.05).
Table 7 antibody-producting cell is tested
Antibody tormation test in, 0.8g/kg.bw and 1.2g/kg.bw dosage group, its antibody-producting cell number with compare
Group is compared by mice, has significant difference (P < 0.05), and 1.2g/kg.bw dosage group difference is more notable (P < 0.01).
Table 8 serolysin test
In serolysin test, each dosage group is compared with matched group, and there were significant differences for the antibody product in Mice Body
(P < 0.05), 0.8g/kg.bw and 1.2g/kg.bw dosage group difference is more notable (P < 0.01).
Table 9 lymphocyte transformation test
In lymphocyte transformation test, 0.8g/kg.bw and 1.2g/kg.bw dosage group, its optical density difference with compare
Group mice compares all that there were significant differences (P < 0.05).
Table 10 NK cytoactive detection is tested
In NK cytoactive detection is tested, 0.8g/kg.bw with 1.2g/kg.bw dosage group is compared with matched group, and NK is thin
Cytoactive rate has significant difference (P < 0.01).
Immune effect test proves, is recommending 10-30 times of agent, and compound preparation is to the body weight of mice, body weight gains, dirty
The most there is not appreciable impact in device/weight ratio, and can cause certain immunoreation, the cell viability of enhancing body, lifting body
Cellular metabolic activity, it is thus possible to effectively play the effect of defying age, resisting fatigue.
6. function of physical fatigue alleviation animal experiment
Using SPF male mice, body must be 18-22g, often group 44, carries out swimming with a load attached to the body, serum urea, blood breast respectively
Acid and hepatic glycogen measure, and during experiment, ambient temperature is 22-24 DEG C, humidity 50-54%.Use the compound recipe system that embodiment 1 obtains
Agent, sets dosage as 0.4g/kg.bw, 0.8g/kg.bw, 1.2g/kg.bw, and with aquesterilisa gavage as matched group, gavage feeds 30
My god.
Table 11 Loaned swimming test
After gavage is fed 30 days, each dosage group mice burden swimming time is obviously prolonged, wherein, and wherein 1.2g/kg.bw agent
Amount group is compared with matched group, and there were significant differences (P < 0.05).
The serum urea detection of table 12 mice
Compared with matched group, itself 0.8g/kg.bw with 1.2g/kg.bw dosage group is compared with matched group, and the serum of mice is urinated
There is significant difference (P < 0.05) in element level.
The change impact of table 13 Mouse Blood lactose
As shown above, compared with matched group, there is not significant difference to the change impact of mice lactose level in each dosage group
(P<0.05)。
Table 14 Mouse Liver glycogen storage level
As shown above, 0.8g/kg.bw with 1.2g/kg.bw dosage group compared with matched group, Mouse Liver glycogen storage level
There is significant difference (P < 0.05).
Function of physical fatigue alleviation animal experiment illustrates, when 1.2g/kg.bw dosage can be obviously prolonged the swimming with a load attached to the body of mice
Between, 0.8g/kg.bw and 1.2g/kg.bw dosage can increase the serum urine after the liver glycogen reserves amount of mice, reduction mouse movement
Element level, Mouse Blood lactose area under curve is had no and significantly affects by each dosage group, illustrates that this compound preparation has alleviation muscle power
Fatigue function.
In sum, the present invention provide defying age, the compound preparation of resisting fatigue, under recommended dose use it is believed that
It is comparatively safe, the effect of defying age, resisting fatigue can be effectively played.
It addition, it will be apparent to those skilled in the art that can technical scheme as described above and design, make other
Various corresponding changes and deformation, and all these change and deformation all should belong to the protection of the claims in the present invention
Within the scope of.
Claims (10)
1. a defying age, the compound preparation of resisting fatigue, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make:
Compound preparation the most according to claim 1, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make:
Compound preparation the most according to claim 1, it is characterised in that by adjuvant by weight and following Chinese medicinal components
Make:
4. according to the compound preparation described in any one of claim 1-3, it is characterised in that described adjuvant is magnesium stearate.
5. according to the compound preparation described in any one of claim 1-3, it is characterised in that the weight portion of described adjuvant is 0.1-
0.5 part.
6. the method for preparation compound preparation described in claim 1-5, comprises the following steps:
1) pulverize: the Radix Panacis Quinquefolii and the Radix Notoginseng that take formula ratio are pulverized；
2) water carries: take the Radix Astragali of formula ratio, Ganoderma, Rhizoma Polygonati, Fructus Lycii, boiling, takes extracting solution, and concentrating under reduced pressure obtains extractum,
Vacuum drying, pulverizes；
3) preparation: by step 1) pulverize after material and step 2) pulverize after material, add adjuvant mix homogeneously, packaging.
Method the most according to claim 6, it is characterised in that step 2) in, add water volume for material cumulative volume after mixing
8-12 times, decoct 2 times, each decocting time is 2-3 hour.
Method the most according to claim 6, it is characterised in that step 2) in, being concentrated into relative density is 1.25-1.30.
Method the most according to claim 6, it is characterised in that step 2) in, the pressure of concentrating under reduced pressure is 0.06-
0.08Mpa, temperature is 70-80 DEG C.
Method the most according to claim 6, it is characterised in that step 3) in, described adjuvant is magnesium stearate, fills glue
Capsule is packed.
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