CN101185727B - Traditional Chinese medicine preparation containing ginseng and pilose antler capable of nourishing heart and nourishing kidney - Google Patents
Traditional Chinese medicine preparation containing ginseng and pilose antler capable of nourishing heart and nourishing kidney Download PDFInfo
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- CN101185727B CN101185727B CN2007101935069A CN200710193506A CN101185727B CN 101185727 B CN101185727 B CN 101185727B CN 2007101935069 A CN2007101935069 A CN 2007101935069A CN 200710193506 A CN200710193506 A CN 200710193506A CN 101185727 B CN101185727 B CN 101185727B
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Abstract
The invention provides a traditional Chinese medicine preparation for nourishing heart and reinforcing kidney, which comprises deer antler, ginseng, south dodder seed (liquor making), desertliving cistanche, prepared tuber fleeceflower root, rhizoma polygonati, Chinese magnoliavine fruit, spina date seed, hawthorn fruit, garlic (fresh) and so on, the traditional Chinese medicine preparation is prepared by scientific processing method and is used for the treatment of various diseases caused by deficiency of both yin and yang of heart and kidney; the invention is the pure traditional Chinese medicine preparation, the toxicity and side effects are small, the efficacy is significant, the clinical symptoms are disappeared rapidly, and no rebound phenomenon is existed after cure.
Description
Technical field
The present invention discloses a kind of ginseng and pilose antler nourishing the heart and kidney Chinese medicine preparation and preparation technology thereof, belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology
Suffering from a deficiency of the kidney is person in middle and old age's commonly encountered diseases, main and endocrine regulation, and psychological factor, nerve etc. are relevant, heart kidney insufficiency can cause vertigo and tinnitus, spiritlessness and weakness, shortness of breath and palpitation, dysphoria with feverish sensation in the chest palms and soles, two dryness and uneasy feeling of the eye, insomnia and dreamful sleep, soreness of the waist and knees, spontaneous sweating and impotence and premature ejaculation etc., operative treatment is comparatively painful, the method of this disease of traditional treatment mainly is oral or non-oral drugs, onset is slow, and it is short to keep effective time, and untoward reaction is more.
Summary of the invention
The invention provides a kind of ginseng and pilose antler nourishing the heart and kidney Chinese medicine preparation, be pure Chinese medicinal preparation, toxic and side effects is little, and it is evident in efficacy to be used for the treatment of the various diseases that is caused by heart kidney insufficiency.
The object of the present invention is achieved like this: with motherland's Chinese medicine heart kidney insufficiency to pathogenesis is managed and the Therapeutic Principle, the selected Chinese herbal medicine that has invigorating heart and kidney, promotes the production of body fluid effects such as moisturizing, QI invigorating is enriched blood is prepared into Chinese medicine preparation through the science processing procedure.
Following consumption is weight portion, and basic recipe is as follows:
Cornu Cervi Pantotrichum 35～45, Radix Ginseng 110～130, Fructus Crataegi 110～120, Rhizoma Polygonati 110～130,
Herba Cistanches 110～130, Radix Polygoni Multiflori Preparata 150～180, Semen Ziziphi Spinosae 110～130,
Fresh garlic 120～160, Fructus Schisandrae Chinensis 110～130, processed with wine Semen Cuscutae 110～130;
Concrete preparation technology is as follows:
Take by weighing above medicine in proportion, the Radix Ginseng powder who gets Cornu Cervi Pantotrichum and 1/2 amount is broken into fine powder; Get the Bulbus Allii lyophilization, be ground into fine powder; All the other medicines such as Radix Ginseng, Radix Polygoni Multiflori decoct with water secondary, add 8 times of amounts of water at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge decoction liquor, being concentrated into relative density is the thick paste of 1.35～1.45 (50 ℃); Radix Ginseng and velvet powder are mixed with thick paste, and 80 ℃ of dryings are ground into fine powder, add the about 20g of starch-dextrin (3: 2) mixture, mixing, paste granule with 12% starch, drying, granule and lyophilizing Bulbus Allii fine powder merge, and add magnesium stearate 2.1g, mixing is pressed into 1000, coating, promptly.
On the basis of basic recipe, add following better drug curative effect:
Fructus Mori 110～130, Radix Puerariae 110～130, Flos Sophorae 110～120, Pheretima 110～130.
Preparation technology:
Fructus Mori, Radix Puerariae, Flos Sophorae, Pheretima are taken by weighing in proportion, and all the other medicines such as Radix Ginseng, Radix Polygoni Multiflori of incorporating above-mentioned preparation technology into decoct with water step, until compress tablet coating.
Above-mentioned medicament can be a said dosage form on any pharmaceutics.
Function cures mainly: invigorating heart and kidney.Be used for due to the heart kidney insufficiency vertigo and tinnitus, spiritlessness and weakness, have a delicate constitution, shortness of breath and palpitation, immunity degradation, dysphoria with feverish sensation in the chest palms and soles, two dryness and uneasy feeling of the eye, insomnia and dreamful sleep, feel dizzy, disease such as soreness of the waist and knees, hypomnesis, spontaneous perspiration, night sweat, sexual impotence, premature ejaculation.
Usage and consumption: oral, one time 4,3 times on the one; Every heavy 0.42g.
The Fang Xieyu pharmacology analysis:
Cornu Cervi Pantotrichum, Radix Ginseng are principal agent in the side, get strong kidney yang, the enrich and benefit essence and blood of Cornu Cervi Pantotrichum, the effect of strengthening the tendons and bones; Get the effect that the strongly invigorating primordial QI of Radix Ginseng, multiple arteries and veins take off admittedly, promote the production of body fluid, calm the nerves, win disease determined curative effects such as the empty cold extremities of body, heart failure to prolonged illness is empty; Help simultaneously with Semen Cuscutae, Fructus Mori, Rhizoma Polygonati, blood-enriching qi-invigorating yin nourishing; Tonification kidney yang, benefiting essence-blood, the convergence that is aided with Herba Cistanches, Radix Polygoni Multiflori Preparata again is astringent or styptic treatment for spontaneous sweating, the characteristics of supplementing QI for promoting the production of body fluid strengthening the tendons and bones, the effect that Fructus Mori, Rhizoma Polygonati, Radix Puerariae, Flos Sophorae etc. have boosting qi and nourishing yin, nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, promote the production of body fluid and moisturize, but clearing away liver-fire, circulation of qi promoting dissipating blood stasis, promote the production of body fluid moisturize, heat clearing away arresting convulsion, activating qi and collateral, removing heat from blood, hemostasis, the effect of yang invigorating antidiarrheal, the palpitation and insomnia that deficiency of kidney yin is caused, the interior-heat mouth is drunk, fatigue and asthenia, stiff nape and back, puckery, the dizzy tinnitus of liver-heat order, and symptoms such as early whitening of beard and hair give to correct with slow; Tonifying YANG on the basis of nourishing kidney yin, reach equilibrium between yin and yang in the body, system balancing in the conditioning human body, thereby finish tonifying YANG and do not decrease the moon, nourishing YIN is the therapeutical effect of tonifying YANG again, be used for due to the heart kidney insufficiency vertigo and tinnitus, spiritlessness and weakness, have a delicate constitution, shortness of breath and palpitation, immunity degradation, dysphoria with feverish sensation in the chest palms and soles, two dryness and uneasy feeling of the eye, insomnia and dreamful sleep, feel dizzy, disease such as soreness of the waist and knees, hypomnesis, spontaneous perspiration, night sweat, sexual impotence, premature ejaculation.
Be animal model with the hydrocortisone deficiency of kidney-YANG syndrome below, prove that medicine of the present invention causes the treatment of diseases effect to heart kidney insufficiency.
1 material
1.1 animal
Kunming mouse, body weight 18-22g, male and female half and half are purchased the Experimental Animal Center in Jilin University, the quality certification number: 10-1023; Kunming mouse, body weight 18-20g, male and female half and half are purchased in Changchun Biological Products Institute, the quality certification number: SCXK-2002-0001.
1.2 medicine
Hydrocortisone, Shandong Boshan pharmaceutical factory, lot number: 040412.
Medicine of the present invention is provided by the Drug Manufacturing Room of this institute, and content of puerarin must not be lower than 1.44mg in every capsules
2 experimental techniques and result
2.1 influence the experimental technique of non-specific immunity
16～18g mice is got in experiment, every batch of same sex, and it is as shown in table 1 to divide into groups.Medicine of the present invention is once a day irritated stomach 35mg/kg, 70mg/kg, and 140mg/kg, continuous 5 days, eye socket blood-letting next day was cutd open and is got spleen and weigh.Other gets 18～19g mice, and medicine of the present invention is once a day irritated stomach 35mg/kg, and continuous 6 days, simultaneously at the 1st, 3,5 day lumbar injection meticortelone 15mg/kg, or the 4th day intraperitoneal injection of cyclophosphamide 60mg/kg be once after giving medicine of the present invention.By table 1 as seen, it is heavy that medicine of the present invention work increases spleen, and can make the spleen weight of meticortelone and cyclophosphamide group mice significantly go up (seeing Table 1).
Table 1 medicine of the present invention is to the effect of the influence of mouse spleen weight and antagonism immunosuppressant (X ± SE)
Compare * * p＜0.01, * * * p＜0.001 with matched group; Compare with the inhibition group
△ △P＜0.01,
△ △ △P＜0.001 (down together)
2.2 medicine of the present invention influences mice peripheral blood T cells percentage ratio
70 of mices are got in experiment, are divided into 7 groups (seeing Table 2), and medicine group (1: 1 water decoction-alcohol sedimentation liquid) is pressed 10mg/kg every day and irritated stomach, simultaneously subcutaneous injection hydrocortisone 40mg/kg; Blank group is with the volume ionized water, and the hydrocortisone group gives dosage same as described above, continuous 8 times.1h after the last administration cuts the Mus tail and gets blood smear, hatches, dyeing, microscopy, and every animal blood smear specimen is all looked into 100 lymphocytes, calculates the lymphocytic percentage ratio of T.By table 2 result as can be known, the hydrocortisone group makes T cell percentage ratio be starkly lower than blank group.And the T cell percentage ratio of medication group does not relatively have equal notable difference with blank group.Medicine medicinal part of the present invention is described, can resists the immunosuppressive action of hydrocortisone.
Table 2 drug combination hydrocortisone of the present invention is to the influence of mice peripheral blood T cells percentage ratio (X ± SE)
2.3 medicine of the present invention is to the influence of survival time of mice
100 of the Kunming mouses at 13 monthly ages (Jilin University's Experimental Animal Center provides), wherein male mice is 40,60 of female mices.Be divided into two groups at random, every group of mice divided and supports in 25 mouse cages, and wherein male and female are with 20 couple of cage, two female 5 couples with cage.Raise under the same conditions, the receptacle temperature is 22～31 ℃.The administration group is baked the medicine cookies with drug substance contents of the present invention and is fed group's (calling the medicine group in the following text), and dosage is equivalent to 20 times of clinical adult's dosage, and feed once every day, and mice is fully taken food, and remainder is provided with feedstuff cookies and Semen Tritici aestivi.Control group mice is fed with feedstuff cookies and Semen Tritici aestivi.The life cycle of this laboratory observation mice and the fertility condition of female mice.
Test till 26 monthly ages of mice, remaining Aged Mice alive this moment provides and makes further experiment and use.
(1) mouse death rate: till 26 monthly ages, dead 37 of control group mice is survived 13, and mortality rate is dead 32 of 74% a medicine group mice, survives 18, and mortality rate is 64%.
(2) dead mouse number of elements and time: see Table 3
Table 3 medicine of the present invention is to the influence of mouse diing time (X ± SE)
The half death time of (3) two groups of mices: the half death time of matched group is 642 days.The half death time of medicine group is 689 days.
On average the survive comparison of natural law of (4) two groups of mices sees Table 4
Table 4 medicine group is on average the survive influence (X ± SE) of natural law of mice
￠p＜0.05
Medicine group energy significant prolongation mouse life is described by statistics, and not remarkable to female Mus statistics, male Mus is remarkable.
2.4 medicine of the present invention is to the effect of androgen sample
Select body weight male mice 9～14 childhood, etherization, excision both sides testis.Postoperative was divided into matched group, administration group (filling stomach) on the 7th day at random.Be administered once every day, continuous 14 days.In administration the 15th day, put to death animal, cut the seminal fluid capsule and weigh.Calculate seminal fluid capsule weight percent, and do the t test.Test sees Table 5
Table 5 medicine androgen of the present invention sample exercising result (X ± SE)
Illustrate that by statistics medicine of the present invention is remarkable to androgen-like action.
2.5 medicine of the present invention is to the influence of rat chest gland weight childhood
Get rat childhood, weigh 70 ± 10g, male and female half and half.Random packet, the medicine group is baked the medicine cookies with drug substance contents of the present invention and is fed group, and dosage is 35mg/kg, and feed once every day, and mice is fully taken food, and remainder is provided with feedstuff cookies and Semen Tritici aestivi.Control group mice is fed with feedstuff cookies and Semen Tritici aestivi.Once a day, continuous 5 days.24h puts to death animal after the last administration, takes out thymus and weighs, and it is heavy to calculate every 100g body weight thymus.The results are shown in Table 6
Table 6 medicine of the present invention is to the result of the test of rat chest gland weight childhood (X ± SE)
The obvious atrophy of administration group thymus illustrates that medicine has the effect of 17-hydroxy-11-dehydrocorticosterone sample.
Good effect of the present invention is: prescription is based on pure Chinese medicinal preparation, causes the curative effect of disease higher to heart kidney insufficiency, and treating both the principal and secondary aspects of a disease is evident in efficacy, has no adverse reaction, and has no side effect, and clinical symptom disappearance is rapid, cures the no rebound phenomena in back.
The specific embodiment:
Further describe the present invention for example by following examples, and do not limit the present invention in any way.
Embodiment 1
Take by weighing Cornu Cervi Pantotrichum 40g, Radix Ginseng 120g, Semen Cuscutae (processed with wine) 120g, Herba Cistanches 120g, Radix Polygoni Multiflori Preparata 160g, Rhizoma Polygonati 120g, Fructus Schisandrae Chinensis 120g, Semen Ziziphi Spinosae 130g, Fructus Crataegi 130g, Bulbus Allii (aquatic foods) 140g respectively, Cornu Cervi Pantotrichum and 1/2 Radix Ginseng powder who measures are broken into fine powder; Get the Bulbus Allii lyophilization, be ground into fine powder; All the other medicines such as Radix Ginseng, Radix Polygoni Multiflori decoct with water secondary, add 8 times of amounts of water at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.35～1.45 (50 ℃); Above-mentioned Radix Ginseng, velvet powder are mixed with thick paste, dry below 80 ℃, be ground into fine powder, add the about 20g of starch-dextrin (3: 2) mixture, mixing pastes granule with 12% starch, dry, granule and lyophilizing Bulbus Allii fine powder merge, and add magnesium stearate 2.1g, mixing, be pressed into 1000, coating, the technical parameter of coating: the rotating speed of coating pan is 43-50 rev/min, pathogenic wind-warm is 48-55 ℃.
Embodiment 2
On the prescription basis of embodiment 1, other gets Fructus Mori 120g, Radix Puerariae 120g, Flos Sophorae 120g, Pheretima 120g, connects all the other medicines such as Radix Ginseng, Radix Polygoni Multiflori and decocts with water step, until compress tablet coating.
Embodiment 3
Take by weighing Cornu Cervi Pantotrichum 45g, Radix Ginseng 110g, Semen Cuscutae (processed with wine) 120g, Herba Cistanches 120g, Radix Polygoni Multiflori Preparata 180g, Rhizoma Polygonati 110g, Fructus Schisandrae Chinensis 110g, Semen Ziziphi Spinosae 110g, Fructus Crataegi 120g, Bulbus Allii (aquatic foods) 150g, Fructus Mori 120g, Radix Puerariae 110g, Flos Sophorae 110g, Pheretima 110g respectively, Cornu Cervi Pantotrichum and 1/2 Radix Ginseng powder who measures are broken into fine powder; Get the Bulbus Allii lyophilization, be ground into fine powder; All the other medicines such as Radix Ginseng, Radix Polygoni Multiflori decoct with water secondary, add 8 times of amounts of water at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.35～1.45 (50 ℃); Above-mentioned Radix Ginseng, velvet powder are mixed with thick paste, dry below 80 ℃, be ground into fine powder, make capsule preparations, other should meet under People's Republic of China's version pharmacopeia in 2000 capsule item.
Embodiment 4
Take by weighing Cornu Cervi Pantotrichum 35g, Radix Ginseng 130g, Semen Cuscutae (processed with wine) 110g, Herba Cistanches 110g, Radix Polygoni Multiflori Preparata 160g, Rhizoma Polygonati 130g, Fructus Schisandrae Chinensis 130g, Semen Ziziphi Spinosae 120g, Fructus Crataegi 110g, Bulbus Allii (aquatic foods) 160g, Fructus Mori 130g, Radix Puerariae 130g, Flos Sophorae 120g, Pheretima 130g respectively, Cornu Cervi Pantotrichum and 1/2 Radix Ginseng powder who measures are broken into fine powder; Get the Bulbus Allii lyophilization, be ground into fine powder; All the other medicines such as Radix Ginseng, Radix Polygoni Multiflori decoct with water secondary, add 8 times of amounts of water at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.35～1.45 (50 ℃); Above-mentioned Radix Ginseng, velvet powder are mixed with thick paste, dry below 80 ℃, be ground into fine powder, make concentrated pill and water-honeyed pill by the preparation technology of concentrated pill and water-honeyed pill, other should meet under People's Republic of China's version pharmacopeia in 2000 concentrated pill and the water-honeyed pill item.
Embodiment 5
Take by weighing Cornu Cervi Pantotrichum 30g, Radix Ginseng 110g, Semen Cuscutae (processed with wine) 125g, Herba Cistanches 115g, Radix Polygoni Multiflori Preparata 170g, Rhizoma Polygonati 115g, Fructus Schisandrae Chinensis 125g, Semen Ziziphi Spinosae 125g, Fructus Crataegi 115g, Bulbus Allii (aquatic foods) 155g, Fructus Mori 125g, Radix Puerariae 130g, Flos Sophorae 120g, Pheretima 115g respectively, Cornu Cervi Pantotrichum and 1/2 Radix Ginseng powder who measures are broken into fine powder; Get the Bulbus Allii lyophilization, be ground into fine powder; All the other medicines such as Radix Ginseng, Radix Polygoni Multiflori decoct with water secondary, add 8 times of amounts of water at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.35～1.45 (50 ℃); Above-mentioned Radix Ginseng, velvet powder are mixed with thick paste, dry below 80 ℃, be ground into fine powder, make drop pill by the preparation technology of drop pill, or make soft capsule, promptly by preparation of soft capsule technology.
Claims (4)
1. nourishing the heart and kidney Chinese medicine preparation is characterized in that it mainly being to be made by following materials of weight proportions medicine:
Cornu Cervi Pantotrichum 35～45g, Radix Ginseng 110～130g, Fructus Crataegi 110～120g, Rhizoma Polygonati 110～130g,
Herba Cistanches 110～130g, Radix Polygoni Multiflori Preparata 150～180g, Semen Ziziphi Spinosae 110～130g,
Fresh garlic 120～160g, Fructus Schisandrae Chinensis 110～130g, processed with wine Semen Cuscutae 110～130g.
2. according to the described Chinese medicine preparation of claim 1, it is characterized in that also being added with following materials of weight proportions medicine and make:
Fructus Mori 110～130g, Radix Puerariae 110～130g, Flos Sophorae 110～120g, Pheretima 110～130g.
3. according to the preparation technology of the described Chinese medicine preparation of claim 1, it is characterized in that: take by weighing above medicine in proportion, the Radix Ginseng powder who gets Cornu Cervi Pantotrichum and 1/2 amount is broken into fine powder; Get the Bulbus Allii lyophilization, be ground into fine powder; All the other medicines such as Radix Ginseng, Radix Polygoni Multiflori decoct with water secondary, add 8 times of amounts of water at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge decoction liquor, be concentrated into 50 ℃ of relative densities and be 1.35～1.45 thick paste; Radix Ginseng and velvet powder are mixed with thick paste, and 80 ℃ of dryings are ground into fine powder, add starch--and dextrin is 3: 2 mixture 20g, mixing, paste granule with 12% starch, drying, granule and lyophilizing Bulbus Allii fine powder merge, and add magnesium stearate 2.1g, mixing is pressed into 1000, coating, promptly.
4. according to the preparation technology of the described Chinese medicine of claim 2, it is characterized in that: Fructus Mori, Radix Puerariae, Flos Sophorae, Pheretima are taken by weighing in proportion, and all the other medicines such as Radix Ginseng, Radix Polygoni Multiflori of incorporating the described preparation technology of claim 3 into decoct with water step, until compress tablet coating.
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| CN2007101935069A CN101185727B (en) | 2007-12-07 | 2007-12-07 | Traditional Chinese medicine preparation containing ginseng and pilose antler capable of nourishing heart and nourishing kidney |
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| CN105902875A (en) * | 2016-06-27 | 2016-08-31 | 马健 | Pharmaceutical composition for treating night sweat of children |
| CN109865067A (en) * | 2019-04-11 | 2019-06-11 | 蒋付正 | A kind of functionality Tea containing traditional Chinese medicine |
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| CN1382784A (en) * | 2001-04-26 | 2002-12-04 | 王凤越 | Medical wine for invigorating vital function of kidney and its preparing process |
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| CN1382784A (en) * | 2001-04-26 | 2002-12-04 | 王凤越 | Medical wine for invigorating vital function of kidney and its preparing process |
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