CN101703631B - Chinese medicinal preparation for treating menopausal syndromes and impotence and preparation method thereof - Google Patents
Chinese medicinal preparation for treating menopausal syndromes and impotence and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating menopausal syndromes and impotence and a preparation method thereof. The Chinese medicinal preparation comprises the main raw material medicaments in part by weight: 3 to 18 parts of ginseng, 2 to 16 parts of flos caryophyllata, 2 to 12 parts of Chinese eaglewood, 3 to 18 parts of szechuan lovage rhizome, 6 to 30 parts of tribulus terrestris and 6 to 30 parts of tuber fleeceflower root. The preparation method comprises the following steps: 1, cleaning medicinal materials, stir-frying hulled sharpleaf galangal fruit, stir-frying desertliving cistanche and pangolin scales, processing south dodder seed and the tuber fleeceflower root with wine, and stir-frying the tribulus terrestris, wherein thinleaf milkwort root-bark is prepared thinleaf milkwort root-bark; 2, drying and pulverizing the medicinal materials to 100 to 200-mesh powders, and mixing the powders uniformly; 3, putting the powders in an extractor for decoction for two times, merging two-time filtered decoction to obtain an active extract, concentrating the active extract into thick paste of which the density is between 1.30 and 1.35, and pulverizing the thick paste into the 100 to 200-mesh powders; and 4, adding adjuvant materials into the powders to prepare capsules and tablets in the conventional process. The Chinese medicinal preparation has the effects of nourishing yin and heart, calming the mind and soothing the nerves, improving the level of female hormone, activating blood circulation and stimulating meridians, preventing and treating osteoporosis and addressing both the symptoms and root causes, and has obvious curative effect, short treatment period and low recurrence rate.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, specifically refer to a kind of Chinese medicine preparation of treating climacteric syndrome and impotence and preparation method thereof.
Background technology:
Climacteric syndrome and impotence are a kind of common middle aged and aged women diseases, and not only sickness rate is high, has a strong impact on women's health, and the trend of rejuvenation is arranged.Especially in modern times people's rhythm of life is fast in the life, stress big, fat, diet and erratic sexual life mode; Very easily cause " menses ends " three YANG pulse to decline in last; Ovarian function descends; Estrogen level reduces, and symptoms such as insomnia forgetfulness, cardiopalmus agitation, extremities aching pain, osteoporosis, headache tinnitus, nervous dysfunction and detest sexual life occur.
It is theoretical to press Chinese medical discrimination; Cause the main etiology and pathogenesis of climacteric syndrome and impotence to be; Due to accumulateing in deficiency of both QI and YIN, cloudy smart consume, deficiency of kidney-YIN, disorder of emotion, asthenia of essence and blood, the long-pending heat; Treatment should reach the treating both the principal and the secondary aspects of a disease at the same time purpose with nourishing YIN to benefit the heart, depressed liver-energy dispersing and QI regulating, the kidney invigorating and essence nourishing, the sharp brain of spleen invigorating, promoting blood circulation to restore menstrual flow.Have multiple complementing estrogen medicine to be used for alleviating climacteric and impotence symptom in the market, but mostly curative effect is not obvious, the cycle is long, and takes the estrogens medicine for a long time and can cause side effect greatly, does not reach the purpose of effective healing.
Summary of the invention:
The purpose of this invention is to provide a kind of treating both the principal and the secondary aspects of a disease at the same time, the Chinese medicine preparation of obvious curative effect treatment climacteric syndrome and impotence, and treatment cycle is short, relapse rate is low, does not take for a long time to cause side effect.Another object of the present invention is to provide a kind of Chinese medicine preparation method for preparing of treating climacteric syndrome and impotence.
The objective of the invention is to realize like this, its primary raw material medicine and weight proportion are following:
Radix Ginseng 3-18 part, Flos Caryophylli 2-16 part, Lignum Aquilariae Resinatum 2-12 part, Rhizoma Chuanxiong 3-18 part, Fructus Tribuli 6-30 part, Radix Polygoni Multiflori 6-30 part.
Optimum weight proportioning of the present invention is following: 5 parts of Radix Ginsengs, 2 parts of Flos Caryophyllis, 2 parts of Lignum Aquilariae Resinatum, 4 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Tribulis, 6 parts of Radix Polygoni Multiflori.
The present invention also comprises one of following crude drug or its combination:
Radix Polygalae 2-16 part, Fructus Alpiniae Oxyphyllae 3-18 part, Squama Manis 3-18 part, Fructus Schisandrae Chinensis 3-18 part, Rhizoma Curculiginis 3-18 part, Radix Angelicae Sinensis 3-18 part, Radix Aconiti Lateralis Preparata 4-40 part, Herba Cistanches 5-28 part, Semen Cuscutae 5-28 part, hippocampus 3-18 part, Radix Bupleuri 3-18 part, Rhizoma Dioscoreae Septemlobae 4-20 part, Radix Glycyrrhizae 2-16 part.
Be the monarch drug group with Radix Ginseng, Flos Caryophylli, Lignum Aquilariae Resinatum, Radix Polygalae, Fructus Alpiniae Oxyphyllae in the side.Radix Ginseng, strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind; The regulating action that the central nervous system is arranged can obviously promote learning capacity and memory, and cerebral blood flow and brain energy metabolism are had facilitation; Can increase adrenocortical hormone secretion, increase uterus and ovary weight, prolong female rats rutting period.Flos Caryophylli, the warming the kidney sending down the abnormal ascending QI has the sombre effect of anti-bacteria and anti-virus treatment.Lignum Aquilariae Resinatum, warming middle-JIAO to send down the adverse QI, the warming the kidney improving inspiration by invigorating kidney-QI has regulating action to the central nervous system.Can obviously prolong mouse sleep time, and digestive system is had the enhancing Digestion.Radix Polygalae, intelligence promoting and the mind tranquilizing has maincenter calmness and anticonvulsant action, can promote muscle power, intelligence to strengthen.Fructus Alpiniae Oxyphyllae is calmed the nerves and is reduced phlegm, and the warming the spleen warming the kidney has mind tranquilizing and the heart calming, dementia and delaying senility function.Above-mentioned five kinds of Chinese medicine strongly invigorating primordial QI, intelligence promoting and the mind tranquilizing, warming the kidney improving inspiration by invigorating kidney-QI, mind calming spleen invigorating.
With Rhizoma Chuanxiong, Squama Manis, Fructus Schisandrae Chinensis, Rhizoma Curculiginis, when being classified as the ministerial drug group.Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression has coronary blood flow increasing and antiplatelet aggregative activity, and myocardial ischemia and cerebral ischemia are had protective effect, can reduce ovary prostaglandin content, improves uterus progesterone receptor specific bond amount.Squama Manis, promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle; Can significantly increase the bone blood flow volume, reduce peripheral resistance, blood vessel wall is had direct dilating effect and reduces the blood viscosity effect; Fructus Schisandrae Chinensis, restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid; Wheat Protein and promotion metabolism can promote DNA, RNA and protein biosynthesis in the brain, strengthen the cardiovascular blood flow.Rhizoma Curculiginis, dispelling cold and dehumidification can promote ovary and uterus weight obviously to increase, and the effect of the hypothalamic pituitary gonadal axis function of adjusting and excited uterus is arranged.Radix Angelicae Sinensis is enriched blood and is invigorated blood circulation, and menstruction regulating and pain relieving has arrhythmia and anti-cerebral ischemia damnification effect, and can hepatic cholagogic.Above Chinese medicine of the five flavours, promoting blood circulation to restore menstrual flow, restrain astringent or styptic treatment for spontaneous sweating, dispelling cold and dehumidification, menstruction regulating and pain relieving.
With Fructus Tribuli, Radix Aconiti Lateralis Preparata, Herba Cistanches, Semen Cuscutae, Hippocampus is the adjuvant drug group.Fructus Tribuli, the suppressing the hyperactive liver resolving depression can promote female rats to oestrus, and improves reproductive performance, the prevention climacteric syndrome.Radix Aconiti Lateralis Preparata returns the moon and rescues contraryly, can regulate the hypothalamic pituitary adrenal axis dysfunction, and effect of the estrogen of enhancing appearance and resisting myocardial ischemia anoxia functions are arranged.Herba Cistanches, tonifying kidney-yin, beneficial menses have endocrine regulation, promote metabolism, can suppress atherosclerosis, slow down aging.Semen Cuscutae, the kidney invigorating and essence nourishing Gu tire antidiarrheal can make rat ovary and uterus weight increase, has excited gonad (ovary) s function, and myocardial ischemia is had obvious prevention and therapeutical effect.Hippocampus, the kidney invigorating eliminating stagnation has the effect of estrogen appearance, and the prolongation in rutting period of normal female mice, uterus and ovary weight are increased.Above Chinese medicine of the five flavours, recuperating depleted YANG and rescuing the patient from collapse, the suppressing the hyperactive liver resolving depression, replenishing kidney-YIN strengthens female sexual function.
With Radix Polygoni Multiflori, Radix Bupleuri, Rhizoma Dioscoreae Septemlobae, Radix Glycyrrhizae is the messenger drug group.The Radix Polygoni Multiflori, nourishing the blood and yin, the detoxifcation of dispeling the wind has anti-inflammatory and antalgic, improves immunity function, Radix Bupleuri, detoxifcation is brought down a fever, and dispersing the stagnated live-QI to relieve the stagnation of QI has antiinflammatory, antibiotic, antiviral and refrigeration function, and liver is had obvious protective effect.Rhizoma Dioscoreae Septemlobae, wind-damp dispelling, dampness removing is turbid, and function of resisting osteoporosis is arranged, and can breed by stimulating osteoblast, suppresses bone loss, improves bone density.Radix Glycyrrhizae, heat-clearing and toxic substances removing is in harmonious proportion hundred medicines.More than four flavor Chinese medicines, dispel the wind detoxifcation and middle emergency, dispersing the stagnated live-QI to relieve the stagnation of QI improves curative effect.
The all Chinese medicine of above-mentioned monarch is respectively executed its effect, nourishing YIN to benefit the heart, intelligence promoting and the mind tranquilizing, warming the spleen warming the kidney; Dispersing the stagnated live-QI to relieve the stagnation of QI is regulated the central nervous system gonad axis (ovary) of unifying, and promotes uterus and ovary weight to increase, the raising serum estrogen level; Inspire rutting period, improve learning capacity and memory, promoting blood circulation to restore menstrual flow reduces blood viscosity; Prevent and treat osteoporosis, prolong the length of one's sleep, treating both the principal and the secondary aspects of a disease at the same time, curative effect is obvious, stable; Treatment cycle is short, relapse rate is low; Cause does not contain the estrogens medicine, do not take for a long time to cause side effect, and the ability health invigorating, resisting fatigue, slow down aging.
The Chinese medicine preparation method for preparing of above-mentioned treatment climacteric syndrome and impotence may further comprise the steps: 1. earlier medical material washed, and stir-frys of shelling of Herba Cistanches processed with wine wherein, Fructus Alpiniae Oxyphyllae, Radix Polygalae is a Radix Polygalae (processed), Squama Manis is fried, Semen Cuscutae processed with wine, Fructus Tribuli stir-fry, Radix Polygoni Multiflori processed with wine; 2. be crushed to 100-200 order fine powder with all medical material natural dryings or after drying, and mix homogeneously.3. put into extractor, soaked 3 hours, decocted 2.5-3 hour for the first time, leach; Decocted 1.5-2 hour for the second time, leach, twice filtrating is merged, get activity extract, stir, it is 1.30-1.35 thick paste shape that filtrating is condensed into density, dries, and pulverizes to be 100-200 order medicated powder; 4. medicated powder is added right amount of auxiliary materials, process capsule, tablet, granule with common process.
Adjuvant is meant filler, lubricant, antiseptic.Filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose.Lubricant comprises one or more in micropowder silica gel, the magnesium stearate.
The clinical trial of Chinese medicine preparation of the present invention, pharmacodynamics and toxicity study result of the test are following:
Clinical test results: the present invention is example through clinical practice for many years with the 45-55 year patient treatment of 168 examples being suffered from climacteric syndrome.41 examples of wherein having a sleepless night, nausea and vomiting 22 examples, forgetful 36 examples, weak 18 examples of cardiopalmus, menoxenia 7 examples, extremities aching pain 35 examples, irritated irritability 9 examples.After the patient took medicine 20,96% patient's symptom has in various degree to be improved, and had patient's symptom of 60.7% to alleviate fully.Specifically see table 1.
Table 1 climacteric syndrome cardinal symptom curative effect table
| Symptom | Alleviate fully | Produce effects | Effectively | Invalid | Add up to |
| Insomnia | 26 | 12 | 3 | 0 | 41 |
| Nausea and vomiting | 14 | 5 | 2 | 1 | 22 |
| Hypomnesis, forgetful | 21 | 11 | 4 | 0 | 36 |
| Nervous weak | 13 | 5 | 0 | 0 | 18 |
| Menoxenia | 4 | 2 | 1 | 0 | 7 |
| Extremities aching pain | 18 | 9 | 3 | 5 | 35 |
| Irritated irritability | 6 | 2 | 1 | 0 | 9 |
The therapeutic evaluation standard:
Alleviate fully: treatment back symptom is improved basically, keeps more than 4 weeks.
Produce effects: treatment back symptom is obviously improved.
Effectively: treatment back symptom has improvement on former basis.
Invalid: as to treat back symptom no change or do not have improvement.
From table, can find out that climacteric syndrome patient's cardinal symptom is obviously improved, treat that laggard promoting the circulation of blood is conventional, routine urianlysis, blood, urine, liver, renal function are normal.
To women's impotence result of the test: to be example to 139 routine age groups impotence patient treatments, 21 examples below 35 years old wherein, 59 examples in 35-42 year; 49 examples in 42-49 year, 10 examples more than 50 are after the patient took medicine 1 month; 96.4% impotence patient sexual function improves in various degree; Libido strengthens, and rutting period can occur: wherein impotence patient's libido of 68.3% obviously strengthens, and success rate of sexual intercourse is more than 75%; Impotence patient's libido enhancing of 22.3% is arranged, the sensation in rutting period is arranged, success rate of sexual intercourse is more than 50%; Have 5.8% impotence patient on original basis, to increase the sexual intercourse requirement, success rate of sexual intercourse is more than 25%.There is 3.6% female patient invalid.Specifically see table 2.
Table 2 age groups impotence curative effect table
| Age | Alleviate fully | Produce effects | Effectively | Invalid | Add up to |
| Below 35 years old | 18 | 3 | 0 | 0 | 21 |
| 35-42 | 44 | 14 | 1 | 0 | 59 |
| 43-49 | 32 | 12 | 3 | 2 | 49 |
| 50-56 | 1 | 2 | 4 | 3 | 10 |
The therapeutic evaluation standard:
Alleviate fully: treatment back libido obviously strengthens, and gets into rutting period fast, and success rate of sexual intercourse kept for 4 weeks more than 75%.
Produce effects: treatment back libido strengthens, and can get into rutting period, and success rate of sexual intercourse is more than 50%.
Effectively: the libido requirement is arranged after the treatment, or on former basis, enhancing is arranged, success rate of sexual intercourse is more than 25%.
Invalid: as to treat the back no change or do not have improvement.
The main pharmacodynamics result:
1, this medicine is to the protective effect of liver
Get 55 of ICR female mices, body weight 19-22g is divided into 5 groups at random by body weight, promptly normal control group, model control group, administration group little, in, heavy dose of group (1.375,2.750,5.500g/kg); Conventional administration 4 days, after the last administration 5 hours, the abdominal cavity was given and 0.2%CCl4, the 0.1ml/10g body weight; Routine is administered once once more simultaneously, and animal fasting subsequently 16 hours is weighed; Mouse orbit venous plexus blood sampling, 300 rev/mins centrifugal 15 minutes, get supernatant and survey ALT, AST.Mice is dissected, got liver, spleen is weighed, and calculates liver, spleen coefficient.See table 3.
The influence of chmice acute hepatic injury each item index that this medicine of table 3 duplicates CCl4
| The normal control group | Model control group | Small dose group (1.375g/kg) | Middle dose groups (2.750g/kg) | Heavy dose of group (5.500g/kg) | |
| Body weight | 21.13±1.20 | 21.96±1.20 | 21.42±1.59 | 21.55±1.35 | 21.78±0.88 |
| The liver coefficient | 4.37±0.25 | 4.77±0.50 | 5.04±0.44 | 4.74±0.16 | 5.07±0.30 |
| The spleen coefficient | 0.41±0.10 | 0.43±0.08 | 0.51±0.10* | 0.47±0.12 | 0.45±0.11 |
| ALT | -11.23±12.10 | 112.16±30.33 | 94.31±35.40 | 101.36±36.67 | 73.69± 31.31 ** |
| AST | 175.04±9.98 | 194.33±9.43 | 198.18±19.28 | 201.82±14.40 | 193.60±9.94 |
Annotate: compare * P＜0.05, * * P＜0.01 with model control group.
From table, can find out lumbar injection 0.2%CCl
4, after the 0.1ml/10g body weight, normal control group and model control group be ALT relatively, and AST all has significant difference, and each dose groups has the obvious suppression effect to the rising of the chmice acute hepatic injury ALT that CCl4 duplicates, and the spleen coefficient shows can effectively strengthen immune function of mice.
2, this medicine influences the hyperlipidemia rats WBV
Get 50 of Wistar female rats, body weight 140 ± 20g is divided into 5 groups at random, and 10 every group, matched group is given with normal diet and fed, and all the other four groups is that high lipid food is fed.Wherein model group (normal saline), little, in, heavy dose of group (1.375,2.750,5.500g/kg) raises and rose in the 16th day, according to group administration or saline, once a day, measures WBV after the 21st day.See table 4.
This medicine of table 4 influences the hyperlipidemia rats WBV
Annotate: compare with model group: * P＜0.05, * * P＜0.01
As can be seen from the table, this Chinese medicine composition can obviously reduce the hyperlipidemia rats WBV.
3, this medicine is to spay rat body weight and uterus weight influence
Get 30 of female rats, be divided into 3 groups at random, wherein normal group is 10; 10 of model group are the removal ovary female rats; 10 of treatment groups (administration group) are the removal ovary female rats, and administration every day 2.75g/kg continued for 12 weeks.Normal group, model group are normal raising, not administration.Sacrifice of animal after 12 weeks is got rat uterus and is weighed, and each organizes rat body weight and the uterus weight situation is seen table 5.
Table 5 is respectively organized rat body weight and uterus weight table
| Group | The example number | Body weight (g) | Uterus heavy (g) | Uterus coefficient (mg/g) |
| Normal group | 10 | 310.32±18.75 | 0.932±0.10 | 3.06±0.50 |
| Model group | 10 | 346.18±23.47 | 0.328±0.066 | 0.94±0.22 |
| The treatment group | 10 | 335.14±16.28 | 0.512±0.058 * | 2.05±0.96 ** |
Annotate: compare with model group: * P＜0.05, * * P＜0.01
As can be seen from the table, female rats body weight after spay obviously increases than normal group, and uterus weight and uterus coefficient obviously reduce, and treatment group body weight and normal group comparison body weight have increase, but with model group minimizing trend are arranged relatively, but not statistically significant.Its uterus weight and uterus coefficient be apparently higher than model group, explains that this medicine has to pick up anti-metratrophia pathological changes function.
4, this medicine is to rat E
2, FSH, LH value influence
Get 30 of female rats, be divided into 3 groups at random, wherein normal group is 10, and 10 of model group are the removal ovary female rats, and 10 of treatment groups (administration group) are the removal ovary female rats.Administration every day 2.75g/kg continued for 12 weeks, and normal group, model group are normal raising, not administration.12 weeks back inspection E
2, FSH, LH situation of change, see table 6.
Table 6 is respectively organized rat E
2, FSH, LH change list
| Group | The example number | E 2(μg/L) | FSH(U/L) | LH(U/L) |
| Normal group | 10 | 33.05±6.81 | 46.19±13.01 | 40.14±13.03 |
| Model group | 10 | 12.13±2.18 | 48.36±1.13 | 28.12±11.14 |
| The treatment group | 10 | 28.44±5.17 ** | 47.12±4.32 * | 29.31±17.16 * |
Compare * P＜0.05, * * P＜0.01 with model group
From table, can find out that the treatment group is got ovary rat blood serum estradiol (E
2) content is than model group (E
2) content obviously raises, FSH slightly reduces, and LH slightly raises, and explains that this medicine obviously has estrogen-like effects.
5, this medicine influences spay rat femur bone density
Get 30 of female rats, be divided into 3 groups at random, wherein normal group is 10, and 10 of model group are the removal ovary female rats, and 10 of treatment groups (administration group) are the removal ovary female rats.Administration every day 2.75g/kg continued for 12 weeks, and normal group, model group are normal raising, not administration.12 weeks back inspection bone density situation of change is seen table 7.
Table 7 is respectively organized rat femur bone density (g/m3) change list
| Group | The example number | Bone density (g/m 3) |
| Matched group | 10 | 0.149±0.018 |
| Model group | 10 | 0.122±0.015 |
| The treatment group | 10 | 0.150±0.023 ** |
Annotate: compare with matched group: * P＜0.05, compare with model group: * * P＜0.01
As can be seen from the table, removal ovary rat model group obviously reduces than normal group bone density, and treatment group (administration group) obviously increases than model group bone density, illustrates that Chinese medicine composition of the present invention can effectively improve bone density, prevents the osteoporosis pathology of removal ovary rat.
6, acute toxicity testing result:
Get 40 of ICR system cleaning level white mice, body weight 18-20g, male and female half and half are divided into 2 groups at random: administration group and matched group, 20 every group.Fasting (can't help water) before the experiment, administration group mice is irritated stomach (ig) with Cmax 0.25g/ml medicated powder and gives and maximum volume 0.8ml/20g.Matched group is irritated the distilled water of stomach equal volume, and administration is 3 times in one day, and the accumulative total dosage is 30g medicated powder/kg, and observe animal behavior activity etc. and animals survived situation in 14 days every day after the administration.Result's table 8 of meeting each other.
This Chinese medicinal composition preparation of table 8 The acute toxicity tests
Annotate: compare * P＞0.05 with matched group
Can find out that from table the toxicity of this Chinese medicine preparation is given mouse stomach with Cmax, maximum volume, animal dead all do not occur, can not ask LD
50Successive administration is 3 times in 1 day, 1 day the accumulative total dosage (maximum dosage-feeding) reach 30g medicated powder/kg, be equivalent to be grown up 210 times of clinical consumption of 70kg by kg body weight conversion, observed the animal no abnormality seen continuously 14 days.The result shows it is safe.
The specific embodiment:
Embodiment 1: get 5 parts of Radix Ginsengs, 2 parts of Flos Caryophyllis, 2 parts of Lignum Aquilariae Resinatum, 4 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Tribulis, 6 parts of Radix Polygoni Multiflori.Wherein Fructus Tribuli is fried, Radix Polygoni Multiflori system.Earlier medical material is washed, be crushed to 100-200 order medicated powder behind the natural drying, put into extractor, extract twice, get activity extract, process capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, yellow wine or plain boiled water take.
Embodiment 2: get 3 parts of Radix Ginsengs, 2 parts of Flos Caryophyllis, 2 parts of Lignum Aquilariae Resinatum, 3 parts of Fructus Alpiniae Oxyphyllae, 2 parts of Radix Polygalaes, 3 parts of Fructus Schisandrae Chinensis; 3 parts of Rhizoma Chuanxiongs, 3 parts of Squama Maniss, 3 parts of Rhizoma Curculiginises, 3 parts of Radix Angelicae Sinensis, 5 parts of Herba Cistanches, 4 parts of Radix Aconiti Lateralis Preparata; 5 parts of Semen Cuscutae, 6 parts of Fructus Tribulis, 6 parts of Radix Polygoni Multiflori, hippocampus 3 part, 2 parts in Radix Glycyrrhizae.Wherein Fructus Tribuli is fried, Radix Polygoni Multiflori system, Semen Cuscutae processed with wine.Earlier medical material is washed, be crushed to 100-200 order medicated powder behind the natural drying, put into extractor, extract twice, get activity extract, process capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, yellow wine or plain boiled water take.
Embodiment 3: get 18 parts of Radix Ginsengs, 16 parts of Flos Caryophyllis, 12 parts of Lignum Aquilariae Resinatum, 18 parts of Fructus Alpiniae Oxyphyllae, 16 parts of Radix Polygalaes; 18 parts of Fructus Schisandrae Chinensis, 18 parts of Rhizoma Chuanxiongs, 18 parts of Squama Maniss, 18 parts of Rhizoma Curculiginises, 18 parts of Radix Angelicae Sinensis; 28 parts of Herba Cistanches, 40 parts of Radix Aconiti Lateralis Preparata, 28 parts of Semen Cuscutae, 30 parts of Fructus Tribulis, 18 parts of Hippocampus; 30 parts of Radix Polygoni Multiflori, 18 parts of Radix Bupleuri, 20 parts of Rhizoma Dioscoreae Septemlobaes, 16 parts in Radix Glycyrrhizae.Wherein Fructus Tribuli is fried, Radix Polygoni Multiflori system, Fructus Alpiniae Oxyphyllae stir-frys of shelling, Radix Polygalae system, Squama Manis stir-fry, Herba Cistanches processed with wine, Semen Cuscutae processed with wine.Earlier medical material is washed, be crushed to 100-200 order medicated powder behind the natural drying, put into extractor, extract twice, get activity extract, process capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, yellow wine or plain boiled water take.
Concrete case
1, patient woman normal headache and dizzy before 54 years old half a year, self-induction cardiopalmus tinnitus, susceptible to lose temper due to restlessness, sleep unreal night, menoxenia, the distention and pain of breast before menstruation costalgia, the pulse condition string is little, after taking medicine one month, transference cures such as headache tinnitus, mammary swelling, sleep is normal, the muscle power enhancing.
2,47 years of patient woman not all right through the several months, spirit depressing, irritated irritability, lower abdominal distention pain, tongue limit purple is dim, deep and hesitant pulse.After taking medicine two months, the eumenorrhea, lower abdominal distention pain disappears, and pulse condition is normal, and through examination in hospital, ovulation is normal, and the subjective symptom libido strengthens.
3, the patient woman cold and pain in the lower abdomen occurs before 35 years old three months, frequent micturition, and libido is indifferent, and vaginal dryness is afraid of the having sexual intercourse thing, a little less than the deep-thready pulse.After taking medicine one month, cold and pain in the lower abdomen disappears, and urine is normal, and libido strengthens, initiatively sexual life.
Claims (3)
1. Chinese medicine preparation of treating climacteric syndrome and impotence, it is characterized in that: its crude drug and weight proportion are following: Radix Ginseng 3-18 part, Flos Caryophylli 2-16 part, Lignum Aquilariae Resinatum 2-12 part, Rhizoma Chuanxiong 3-18 part, Fructus Tribuli 6-30 part, processed with wine Radix Polygoni Multiflori 6-30 part.
2. the Chinese medicine preparation of treatment climacteric syndrome according to claim 1 and impotence is characterized in that: the best proportioning of its crude drug and weight is following: 5 parts of Radix Ginsengs, 2 parts of Flos Caryophyllis, 2 parts of Lignum Aquilariae Resinatum, 4 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Tribulis, 6 parts of processed with wine Radix Polygoni Multiflori.
3. the Chinese medicine preparation of treatment climacteric syndrome according to claim 1 and 2 and impotence is characterized in that: it is capsule, tablet or granule.
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|---|---|---|---|---|
| CN102319365B (en) * | 2011-08-31 | 2013-04-24 | 刘巧 | Shouwu capsules |
| CN102614371B (en) * | 2012-04-08 | 2013-09-04 | 申志恩 | Drug for treatment of female impotence and production method thereof |
| CN102716404A (en) * | 2012-06-29 | 2012-10-10 | 遵义臻坤中草医药研究所 | Medicament for regulating male and female climacteric syndrome and preparation method thereof |
| CN104398697A (en) * | 2014-11-06 | 2015-03-11 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating osteoporosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475237A (en) * | 2002-08-13 | 2004-02-18 | 孙兴望 | Medicine for strengthening yang and tonifying kidney, treating male infecundity and male and female climacteric syndrome |
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- 2009-11-30 CN CN2009102270610A patent/CN101703631B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475237A (en) * | 2002-08-13 | 2004-02-18 | 孙兴望 | Medicine for strengthening yang and tonifying kidney, treating male infecundity and male and female climacteric syndrome |
Non-Patent Citations (1)
| Title |
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| 王琦.杨绍伯老中医治疗阴痿的经验.《辽宁中医杂志》.1988,(第4期),第10-11页. * |
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