CN101690747B - Chinese materia medica preparation for treating impotence and preparation method thereof - Google Patents
Chinese materia medica preparation for treating impotence and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese materia medica preparation for treating impotence and a preparation method thereof. The Chinese materia medica preparation mainly comprises the following bulk pharmaceutical chemicals in parts by weight: 10-80 parts of costus root, 10-70 parts of clove fruit and 40-280 parts of cooked monkshood. The preparation method comprises the following steps: 1. cleaning medicinal materials, processing herba cistanche by wine, and processing cumin by salt; 2. naturally drying the medicinal materials and pulverizing into100-200 meshes of power, and evenly mixing the power; 3. evenly stirring the medicinal powder and mature vinegar according to the ratio of 2:1 and then drying the mixture by distillation; 4. placing the mixture into an extractor for two-time decoction, and mixing the two-time filtrate to obtain active extract, concentrating in dense paste shape with the density of 1.30-1.35, and pulverizing the powder in100-200 meshes; and 5. adding auxiliary materials to prepare into capsules or troche. The Chinese materia medica preparation has the functions of warming kidney, solidifying sperm, improving erection of penis and prolonging erection time, has obvious healing effect, stability, can not induce heart brain diseases, is not harmful for health, can strengthen physique, resist fatigue and delay aging.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, specifically refer to a kind of Chinese medicine preparation for the treatment of sexual impotence and preparation method thereof.
Background technology:
Sexual impotence is a kind of common andropathy, and not only the sickness rate height has a strong impact on men's health, and the trend of oriented rejuvenation development.Particularly in the modern life, people's rhythm of life is fast, and stress is big, eating and drinking too much at one meal, and monophagia excessive drinkings etc. all very easily cause male sexual disorder, the sexual impotence symptom occurs.
Press the Chinese medical discrimination theory, the main etiology and pathogenesis that causes sexual impotence is that deficiency of kidney-YIN, damage of essence harmony stagnate, depressed emotion, caused by energy stagnation and blood stasis.Treatment should reach the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time with supplementing the kidney to control the nocturnal, nourishing YIN and invigorating YANG, QI regulating by alleviation of mental depression, activating blood circulation to dissipate blood stasis.
The Chinese medicine that multiple treatment sexual impotence is arranged in the market, but mostly a side is laid particular stress in the treatment of sexual impotence, how to be its well-established law to control from the kidney opinion, bias toward kidney-replenishing, kidney yin, or it is supporing yang to mend fire, reaches the purpose of the internal energy enhancing penile erectile function of short-term, but cannot not hold time longly, and therapeutic effect is not obvious, easily brings out cardio-cerebral diseases, is harmful to health.
Summary of the invention:
The object of the present invention is to provide a kind of to the impotence treatment effect obviously, stable, strengthen the Chinese medicine preparation of male's sexual, and often use can health invigorating, resisting fatigue, slow down aging can not bring out cardio-cerebral diseases, useful men's health.Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine preparation of sexual impotence.
The object of the present invention is achieved like this, its primary raw material medicine and weight proportion are as follows:
10～80 parts of Radix Aucklandiae (Radix Vladimiriae), 10～70 parts of Fructus Caryophyllis, 40～280 parts of Radix Aconiti Lateralis Preparata.
The present invention also comprises one of following crude drug or its combination: 20～160 parts of Fructus Cnidiis, 20～160 parts of Fructus Corni, 20～160 parts of Radix Morindae Officinaliss, 30～180 parts of Herba Epimedii, 30～180 parts of Herba Cistanches, 30～180 parts of Fructus Tribulis, 30～180 parts of Fructus Foeniculi, 20～160 parts of Cortex Cinnamomis, 20～100 parts of Hippocampus.
Be the monarch drug group with Radix Aucklandiae (Radix Vladimiriae), Fructus Cnidii, Fructus Corni, Radix Morindae Officinalis in the side.The Radix Aucklandiae (Radix Vladimiriae) promoting the circulation of QI to relieve pain, intestinal stasis relieving in the accent has the kidney of disappearing water, the logical motive, the effect of warming the kidney gas.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO is a three warmers edema caused by disorder of QI key medicine, and constuslactone can effectively strengthen enterokinesia, blood vessel dilating, and blood flow increasing increases the effect of adrenocortical hormone sample.Fructus Cnidii can reduce the heart Peripheral resistance, promotes level of adrenocortical hormone, improves levels of serum testosterone content, the rabbit spongy body that lax phenylephrine causes shrinks, and can prevent osteoporosis, and strengthen the rat model ability of learning and memory of suffering from a deficiency of the kidney, brain-invigorating is arranged.Fructus Corni has the cardiac efficiency of raising, the effect of expansion external perihaemal canal, can obviously strengthen the heart blood supply function.Radix Morindae Officinalis has resisting fatigue and raise immunity effect, prevent neural cell injury due to the corticosterone, improve superoxide dismutase activity in heart kidney brain and the testis tissue, increase old and feeble rat epididymis sperm sum, improve chronic stress rat testicle weight and erection number of times.Intestinal stasis relieving during above-mentioned four medicines are transferred, warming the kidney to invigorate YANG, liver and kidney tonifying, bone and muscle strengthening.
With Fructus Caryophylli, Herba Epimedii, Herba Cistanches, Fructus Tribuli is the ministerial drug group.The tonifying YANG of Fructus Caryophylli warming middle-JIAO, the warming the kidney sending down the abnormal ascending QI has anti-bacteria and anti-virus, treatment sexual impotence sombrely to act on.Herba Epimedii has slow down aging, sexual function improving effect.The icariin rabbit cavernous body of penis smooth muscle that can relax improves tremulous pulse erection disturbance rat model erection function, increases Prostato-seminal vesicle adrenal gland's weight and testosterone levels, promotes teenage male rat adenohypophysis, epididymis and seminal vesicle to grow.Herba Cistanches kidney-replenishing, benefiting essence-blood can increase central nervous system in rat hypothalamus noradrenaline cellulose content, and endocrine regulation obviously improves sex gland hormones receptor-specific adhesion, promote metabolism.The sexual strong effect of Fructus Tribuli can promote sperm to form, and strengthens sexual reflex and libido, improves and the prolongation erection time, increases the number and the motion of sperm.
With Radix Aconiti Lateralis Preparata, Fructus Foeniculi, Cortex Cinnamomi, Hippocampus serves as that assistant makes.The Radix Aconiti Lateralis Preparata recuperating depleted YANG is mended fire, the disorder of the central nervous system of adjusting gonad axis, excited hypophysis, the sample effect of increase adrenocortical hormone is arranged and strengthen mental and physical efforts, blood vessel dilating, reduce eosinophil leucocyte number in the peripheral blood, significantly reduce ascorbic acid content in the adrenal gland, yang-warming kidney-nourishing.The Fructus Foeniculi the kidney warming warms up liver, and promoting the circulation of QI to relieve pain have gonadotropic Effect, testis, deferential total protein concentration are reduced, and seminal vesicle and prostatic total protein obviously increase, and sterilization functions is arranged, can effectively suppress prostatitis and prostatic hyperplasia, prolong the erection time.It is supporing yang that Cortex Cinnamomi is mended fire, warming the meridian and promoting blood circulation, and blood circulation promoting and blood stasis dispelling has the obvious treatment effect to insufficiency of kidney-YANG, decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission.The Hippocampus kidney invigorating and YANG supporting, mass dissipating and swelling eliminating has antithrombotic to form, delaying to decline acts on and gonadotropic Effect, can significantly increase male mice sperm count and sperm survival rate.
Above-mentioned monarch is respectively executed its effect, blood vessel dilating, and blood flow increasing, blood circulation promoting improves the reproductive system blood supply insufficiency.By regulating the central nervous system to gonad axis effect, excited hypophysis, the effect of increase adrenocortical hormone sample, the kidney warming controlling nocturnal emission with astringent drugs improves penile erectile function, prolongs the erection time, and therapeutic effect is obvious, stable; This side does not bias toward kidney-replenishing, kidney yin, or the benefit fire is supporing yang, and therefore often use can not brought out cardio-cerebral diseases yet, impair one's health, and the energy health invigorating, resisting fatigue is arranged, delaying senility function.
The preparation method of the Chinese medicine preparation of above-mentioned treatment sexual impotence may further comprise the steps: 1, earlier medical material is washed Herba Cistanches processed with wine wherein, Fructus Foeniculi processed with salt; 2, will be crushed to 100～200 order fine powders after all medical material natural dryings or the oven dry, and mix homogeneously; 3, medicated powder and the mature vinegar ratio in 2: 1 is stirred, put evaporate to dryness in the container; 4, put into extractor again, soaked 3 hours, decocted 2.5～3 hours for the first time, leach; Decocted 1.5～2 hours for the second time, leach.Twice filtrate is merged, get activity extract, stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into density, oven dry, and pulverizing is 100～200 order medicated powder; 5. medicated powder is added right amount of auxiliary materials, make capsule, tablet, granule with common process.
Adjuvant is meant filler, lubricant, antiseptic.Filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose.Lubricant comprises one or more in micropowder silica gel, the magnesium stearate.
The clinical trial of Chinese medicine preparation of the present invention, pharmacodynamics and toxicity study result of the test are as follows:
Clinical test results: the present invention is example through clinical practice for many years with the age groups patient treatment of 238 examples being suffered from sexual impotence.26 examples below 40 wherein, 40～49 years old 102 example, 50～59 years old 92 example, 60-65 year 18 examples.After the patient took medicine 10,97% patient's sexual function had in various degree and to improve, and had patient's libido of 56.3% obviously to strengthen, and success rate of sexual intercourse is more than 75%; Patient's libido of 25.6% strengthens, and success rate of sexual intercourse is more than 50%.Have 15.1% patient to increase the sexual intercourse requirement on original basis, success rate of sexual intercourse is more than 25%.There is 3% patient invalid.Specifically see Table 1.
Table 1 age groups curative effect table
| Age | Cure | Produce effects | Effectively | Invalid |
| Below 40 | 17 | 9 | ||
| 40～49 | 61 | 24 | 16 | 1 |
| 50～59 | 56 | 21 | 12 | 3 |
| 60～65 | 0 | 7 | 8 | 3 |
The therapeutic evaluation standard:
Cure: treatment back libido obviously strengthens, and has than epistasis and desires, and success rate of sexual intercourse kept for 4 weeks more than 75%.
Produce effects: treatment back libido strengthens, and certain libido is arranged, and success rate of sexual intercourse kept for 4 weeks more than 50%.
Effectively: the libido requirement is arranged after the treatment, or on former basis, enhancing is arranged, erection, success rate of sexual intercourse is more than 25%.
Invalid: as to treat the back no change or do not have improvement.
Clinical trial also confirms, treatment cycle and the curative effect relation of being proportionate.Curative effect and age are formed the inverse correlation relation, and a group curative effect that the age is on the low side is better than higher group of age, erection total effective rate 97%.Sexual intercourse improves total effective rate 93%.Each sexual intercourse time average prolongs 86%.Most of patients obviously obtained effect on 6th.Sensitivity person obtained effect on the same day.
The main pharmacodynamics result:
Prove that through results of pharmacodynamic test Chinese medicine composition of the present invention can strengthen the male rat penile erectile function.The Nocturnal penile tumescence monitoring shows that the average erection number of times of different groups and erection all have prolongation total time, and showing has therapeutical effect to the nerve sexual impotence.Can promote immature rat prostate, Seminal vesicle, testicular weight, the adrenal hormone sample effect of promotion and antifatigue effect are arranged, blood viscosity lowering, microcirculation improvement, the effect of increase reproductive system amount of blood supply are arranged.
Mice mating test.Get 30 every group of kunming mices, wherein male 5,25 of female Mus.5 mouse cages of every component are raised.Every male Mus and 5 female Mus are raised with cage.Be divided into blank group (distilled water), heavy dose of group (dosage 15.2g/kg), middle dosage group (dosage 11.4g/kg), small dose group (dosage 7.6g/kg) immediately.Every group of male Mus of gastric infusion, be administered once afternoon every day, continuous 10 days.Every morning checks that female Mus has the depletion of YIN bolt to occur.It is as shown in the table:
Table 2 mice mating test card
| Group | Female Mus example number | Find cloudy bolt example number (10 days) | Cloudy bolt occurrence rate |
| Blank group | 25 | 10 | 40％ |
| Heavy dose of group | 25 | 16 | 64％ |
| Middle dosage group | 25 | 22 | 88％ |
| Small dose group | 25 | 18 | 72％ |
As can be seen from Table 2, this Chinese medicine preparation can obviously promote the male mice mating.
Mice androgen content (plasma testosterone) experiment:
Get 40 of ICR system cleaning level Kunming male mices, every group 10, be divided into blank group (distilled water), heavy dose of group (the bright 15.2g/kg of administration), middle dosage group (dosage 11.4g/kg) and small dose group (dosage 7.6g/kg) at random, every group of gastric infusion, be administered once afternoon every day, after continuous 10 days, mice plucked eyeball get blood, detect blood plasma testosterone content, it is as shown in the table:
Table 3 mice androgen content (plasma testosterone) experiment:
| Group | Male Mus example number | Testosterone concentration (nmol/l) | P |
| Blank group | 10 | 6.18±3.15 | |
| Heavy dose of group | 10 | 28.26±8.15 | ＜0.01 |
| Middle dosage group | 10 | 48.67±7.34 | ＜0.01 |
| Small dose group | 10 | 41.24±9.76 | ＜0.01 |
As can be seen from Table 3, this Chinese medicine preparation can obviously increase the content of male mice plasma testosterone, promotes the male mice mating, improves the male mice sexual function.
The toxicity study result of the test:
Get 40 of ICR system cleaning level male mices, body weight 18～20g is divided into 2 groups at random: administration group and matched group, 20 every group.Fasting (can't help water) is after 14 hours before the experiment, and administration group mice is irritated stomach (ig) and gives and maximum volume 0.8ml/20g with Cmax 0.38g medicated powder/ml.Matched group is irritated the distilled water of stomach equal volume, and administration is 3 times in one day, and the accumulative total dosage is 45.6g medicated powder/kg, and observe animal behavior activity etc. and animals survived situation in 14 days every day after the administration.The result sees the following form mutually
Table 4 treatment sexual impotence Chinese medicine preparation The acute toxicity tests
Compare * P＞0.05 with matched group
As can be seen from Table 4, the toxicity of this Chinese medicine preparation is given mouse stomach with Cmax, maximum volume, animal dead all do not occur, can not ask LD
50Successive administration is 3 times in 1 day, 1 day accumulative total dosage (maximum dosage-feeding) reach 45.6g medicated powder/kg, be equivalent to 70kg by kg body weight conversion and be grown up 709 times of clinical consumption (being be grown up 79 times of clinical consumption of 70kg), observed the animal no abnormality seen continuously 14 days by the body surface area conversion.The result shows it is safe.
The specific embodiment:
Embodiment 1: get 10 parts of Radix Aucklandiae (Radix Vladimiriae), 10 parts of Fructus Caryophyllis, 40 parts of Radix Aconiti Lateralis Preparata.Earlier medical material is washed, be crushed to 100～200 order medicated powder behind the natural drying, and mix homogeneously.Again medicated powder and the mature vinegar ratio in 2: 1 is stirred, put evaporate to dryness in the container.Put into extractor again, extract twice, get activity extract, make capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, plain boiled water is taken after mixing it with water.
Embodiment 2: get 10 parts of Radix Aucklandiae (Radix Vladimiriae), 10 parts of Fructus Caryophyllis, 40 parts of Radix Aconiti Lateralis Preparata, 20 parts of Fructus Cnidiis, 20 parts of Fructus Corni, 30 parts of Herba Epimedii, 30 parts of Fructus Tribulis, 20 parts of Cortex Cinnamomis.Earlier medical material is washed, be crushed to 100～200 order medicated powder behind the natural drying, and mix homogeneously.Again medicated powder and the mature vinegar ratio in 2: 1 is stirred, put evaporate to dryness in the container.Put into extractor again, extract twice, get activity extract, make capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, plain boiled water is taken after mixing it with water.
Embodiment 3: get 80 parts of Radix Aucklandiae (Radix Vladimiriae), 70 parts of Fructus Caryophyllis, 280 parts of Radix Aconiti Lateralis Preparata, 160 parts of Fructus Cnidiis, 160 parts of Fructus Corni, 180 parts of Radix Morindae Officinaliss, 180 parts of Herba Epimedii, 180 parts of Herba Cistanches, 180 parts of Fructus Tribulis, 180 parts of Fructus Foeniculi, 160 parts of Cortex Cinnamomis, 100 parts of Hippocampus.Herba Cistanches processed with wine wherein, the Fructus Foeniculi processed with salt.Earlier medical material is washed, be crushed to 100～200 order medicated powder behind the natural drying, and mix homogeneously.Again medicated powder and the mature vinegar ratio in 2: 1 is stirred, put evaporate to dryness in the container.Put into extractor again, extract twice, get activity extract, make capsule with common process.Every 0.5 gram, usage is every day 2 times, each 4, plain boiled water is taken after mixing it with water.
Concrete case
1, patient man readme in 53 years old begins sexual impotence in the time of 40 years old after marriage.The same branch of a family impotence, premature ejaculation when once in a while sexual life being arranged, the time soreness of waist lumbago arranged.After taking medicine 20, the sexual impotence symptom takes a turn for the better, and soreness of waist lumbago alleviates, but every month sexual life 1～2 time.
2, patient man 41 years old is married.Sexual function degradation before 3 months, impotence.Face thing flaccidity, premature ejaculation, oligospermia when having the inclination sexual life.Sweat with cardiopalmus.After taking medicine 6, libido strengthens, and erection is strong.During the same branch of a family sustainable 10～15 minutes.
3, the patient man libido indifference occurred because operating pressure is big, depressed in 33 years old, and erection is not hard.Erection on the same day after taking medicine serve on 6, and it is normal that sexual function recovers.
Claims (3)
1. Chinese medicine preparation for the treatment of sexual impotence, it is characterized in that: its crude drug and weight proportion are as follows: 10～80 parts of Radix Aucklandiae (Radix Vladimiriae), 10～70 parts of Fructus Caryophyllis, 40～280 parts of Radix Aconiti Lateralis Preparata, 30～180 parts of Fructus Tribulis, 30～180 parts of Fructus Foeniculi, 20～160 parts of Fructus Cnidiis, 20～160 parts of Fructus Corni, 20～160 parts of Radix Morindae Officinaliss, 30～180 parts of Herba Epimedii, 30～180 parts of Herba Cistanches, 20～160 parts of Cortex Cinnamomis, 20～100 parts of Hippocampus.
2. the Chinese medicine preparation of treatment sexual impotence according to claim 1 is characterized in that: it is capsule, tablet or granule.
3. the preparation method of the Chinese medicine preparation of a treatment sexual impotence as claimed in claim 2 is characterized in that: comprise the steps: 1, earlier medical material washed, Herba Cistanches processed with wine wherein, Fructus Foeniculi processed with salt; 2, will be crushed to 100～200 order fine powders after all medical material natural dryings or the oven dry, and mix homogeneously; 3, medicated powder and the mature vinegar ratio in 2: 1 is stirred, put evaporate to dryness in the container; 4, put into extractor again, soaked 3 hours, decocted 2.5～3 hours for the first time, leach; Decocted 1.5～2 hours for the second time, leach; Twice filtrate is merged, get activity extract, stir, it is 1.30～1.35 thick paste shapes that filtrate is condensed into relative density, oven dry, and pulverizing is 100～200 order medicated powder; 5. medicated powder is added right amount of auxiliary materials, make capsule, tablet, granule with common process.
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Effective date of registration: 20230714 Address after: 1219-55, Building 3, No. 1366, Hongfeng Road, Huzhou, Zhejiang Province, 313098 Patentee after: Zhejiang Pinpinshou Pharmaceutical Technology Co.,Ltd. Address before: 902, room 3, building 1, building 2, 100039 section, Beijing Iron home, Beijing West Road, Fengtai District, Beijing Patentee before: Zhu Youwen |
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