CN104800532A - Calcium supplementing substances used in health food - Google Patents
Calcium supplementing substances used in health food Download PDFInfo
- Publication number
- CN104800532A CN104800532A CN201510173143.7A CN201510173143A CN104800532A CN 104800532 A CN104800532 A CN 104800532A CN 201510173143 A CN201510173143 A CN 201510173143A CN 104800532 A CN104800532 A CN 104800532A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- calcium
- herbal medicine
- chinese herbal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides calcium supplementing Chinese herbal medicine used in health food. The calcium supplementing Chinese herbal medicine comprises active pharmaceutical ingredients as follows: psoralea corylifolia linn, cornus officinalis, radix cyathulae, kudzuvine roots, lamium amplexicaule, rheum franzenbachii munt, cryptotaenia japonica hassk, meadowrue root and rhizome, maidenhair, large-flowered gardenia, semen cuscutae, semen euryales, galla chinensis, asparagus, radix adenophorae, common bluebeard herb, indigofera pseudotinctoria, semen astragali complanati and liquorice. The Chinese herbal medicine is applied to edible cookies and adopted to prepare health food, the calcium supplementing effect of the ingredients of the Chinese herbal medicine is sufficiently utilized, and the bone mineral density of a patient with osteoporosis is increased, so that the anti-osteoporosis function is realized.
Description
Technical field
The present invention relates to functional food technical field, particularly relate to the Chinese herbal medicine of replenishing the calcium used in a kind of health food.
Background technology
Osteoporosis (Osteoporosis, OP) be reduce with bone amount, osseous tissue microstructure is degenerated, and (Grafting Cancellous Bone Bolt girder attenuates, rupture, quantity minimizing; Cortical bone porous, thinning) be feature, so that a kind of general osteopathia that the fragility of bone increases and fracture risk increases.Primary osteoporosis is that old people is common, frequently-occurring disease.Along with China steps into aging society, the average life span extends, and prevalence and the complication rate thereof of osteoporosis also improve constantly, and osteoporosis and complication thereof have become life of elderly person Quality Down and dead important diseases.The pathogenesis of osteoporosis is mainly lacked of proper care relevant with endocrine regulation and calcium balance.
Calcium is one of mineral element of needed by human, closely bound up with health.Latest survey confirms, due to China's most people dietary habit, the general calcium deficiency of people of current all ages, especially women, child and old people, calcium deficiency rate is about 50%.And hypocalcia can cause various diseases in human body, as inflexible building disease, osteoporosis etc., calcium required in every day added body not only can the associated disease of prophylactic treatment, can also slow down aging, improve health.The nutritional survey data of China shows, in the diet structure of people, and the intake wretched insufficiency of calcium, especially in old man and child, calcium deficiency phenomenon is very general, cookies is as the most popular bakery product of this colony, and its nutrient composition content enriches, and has wide space and market.
Functional food refers to the food with trophic function, sensory function and adjustment physiological activity function.Its scope comprises: the food strengthening human body constitution (strengthen immunocompetence, activate lymphsystem etc.); Prevent the food of disease (hypertension, diabetes, coronary heart disease, constipation and tumor etc.); Get well and (control cholesterol, prevent platelet aggregation, regulate the food of hemopoietic function; Regulate the food of body rhythms (nerve centre, nerve ending, picked-up and absorption function etc.) and the tableware of slow down aging to have the food of These characteristics, all belong to functional food.
Cookies is the important bakery product integrating the functions such as nutrition, convenience and leisure, and shelf life is long, instant, numerous in variety, and applicable various different crowd and occasion are enjoyed.The biscuit industry growth momentum of China is good, is entering a stable development stage, 2013 annual productions oneself through reaching more than 6,000,000 tons, after nineteen ninety-five over nearly 20 years cracker product annual production with annual 10% to 15% speed increase.But compared with consuming big country with cakes thousand such as Europe, development potentiality is huge, China per capita cookies Year's consumption is only about 1 kilogram, the Year's consumption per capita 25 to 35 kilograms of developed country's cookies, 12 to 18 kilograms of medium-developed country, although due to the dietary habit very different of CHINESE REGION economic disparities and people, perhaps be not very very rational pointer with consumption per capita, but the so huge difference of pre-capita consumption still can show china biscuit market still to be had development greatly and dive.
, in cookies industry, there is the strong new product development tendency be the theme with health in current developed country, particularly Japan.Utilize the various functional nutrient batching of the feature of cookies exploitation interpolation to produce the cookies with specific nutrition function or health care function and achieve huge success.
Along with the exploitation of China's functional food, the particularly exploitation of food function factor, the functional biscuit that Development and Production goes out how applicable specific crowd to be needed is the direction that our cookies industry needs constantly to make great efforts, and thinks customer service, serve the people, realize the market value of enterprise better.Also can avoid better because the concept that had of the light that the deficiency of functional food ingredient causes simultaneously, and the embarrassment of good product without good applicable consumer taste, as the Sugarless type cookies that some producer once developed.
Osteoporosis belongs to " atrophic debility of bones " scope of Chinese medicine, mainly with suffer from a deficiency of the kidney, insufficiency of the spleen and blood stasis is relevant.Its pathogenic characteristic can be summarized as the systemic skeletal disease of many void, many stasis of bloods, multisystem, multi viscera, and the main principle for the treatment of is invigorating the kidney and strengthening the bones, invigorating the spleen and benefiting QI, promoting blood circulation to remove obstruction in the collateral.Adopt the osteoporotic mechanism for the treatment of by Chinese herbs should be Mutiple Targets, too many levels, adopt Chinese medicine can improve Induced by Corticosteroids sufferers of osteoporosis face bone density, improve biochemical markers of bone metabolism and bone biomechanical property, thus play function of resisting osteoporosis, therefore, adopt Chinese herbal medicine to replenish the calcium, treatment osteoporosis has significant effect.
Chinese herbal medicine is applied to edible biscuits by the present invention, is made into health food, makes full use of the effect of supplemented calcium of medicinal herb components, improves the bone density of patients with osteoporosis, thus plays function of resisting osteoporosis.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of health food calcium milk biscuit containing medicinal herb components, and it makes full use of the effect of supplemented calcium of medicinal herb components, improves the bone density of patients with osteoporosis, thus plays function of resisting osteoporosis.
For solving the problems of the technologies described above, the invention provides the Chinese herbal medicine of replenishing the calcium in a kind of health food, its raw material comprises: Fructus Psoraleae, Fructus Corni, Radix Cyathulae, Radix Puerariae, Herba Lamii Amplexicaulis, Radix et Rhizoma Rhei Franzenbachii, Caulis et folium cryptotaeniae japonicae, Radix et Rhizoma Thalictri, Herba Tagetis Patulae, Fructus Gardeniae grandiflorae, Semen Cuscutae, Semen Euryales, Galla Chinensis, Radix Asparagi, Radix Adenophorae, Herba Caryopteridis Incanae, horse sour jujube, Semen Astragali Complanati and Radix Glycyrrhizae.
Wherein, in described Chinese herbal medicine of replenishing the calcium, the weight portion of each crude drug is respectively Fructus Psoraleae 40 weight portion ~ 50 weight portion, Fructus Corni 25 weight portion ~ 35 weight portion, Radix Cyathulae 20 weight portion ~ 30 weight portion, Radix Puerariae 10 weight portion ~ 20 weight portion, Herba Lamii Amplexicaulis 10 weight portion ~ 20 weight portion, Radix et Rhizoma Rhei Franzenbachii 15 weight portion ~ 25 weight portion, Caulis et folium cryptotaeniae japonicae 10 weight portion ~ 20 weight portion, Radix et Rhizoma Thalictri 10 weight portion ~ 20 weight portion, Herba Tagetis Patulae 10 weight portion ~ 20 weight portion, Fructus Gardeniae grandiflorae 15 weight portion ~ 25 weight portion, Semen Cuscutae 25 weight portion ~ 35 weight portion, Semen Euryales 20 weight portion ~ 30 weight portion, Galla Chinensis 20 weight portion ~ 30 weight portion, Radix Asparagi 25 weight portion ~ 35 weight portion, Radix Adenophorae 30 weight portion ~ 40 weight portion, Herba Caryopteridis Incanae 15 weight portion ~ 25 weight portion, horse sour jujube 10 weight portion ~ 20 weight portion, Semen Astragali Complanati 10 weight portion ~ 20 weight portion and Radix Glycyrrhizae 15 weight portion ~ 25 weight portion.
Wherein, in described Chinese herbal medicine of replenishing the calcium, the weight portion of each crude drug is respectively Fructus Psoraleae 43 weight portion ~ 47 weight portion, Fructus Corni 28 weight portion ~ 32 weight portion, Radix Cyathulae 23 weight portion ~ 27 weight portion, Radix Puerariae 13 weight portion ~ 17 weight portion, Herba Lamii Amplexicaulis 13 weight portion ~ 17 weight portion, Radix et Rhizoma Rhei Franzenbachii 18 weight portion ~ 22 weight portion, Caulis et folium cryptotaeniae japonicae 13 weight portion ~ 17 weight portion, Radix et Rhizoma Thalictri 13 weight portion ~ 17 weight portion, Herba Tagetis Patulae 13 weight portion ~ 17 weight portion, Fructus Gardeniae grandiflorae 18 weight portion ~ 22 weight portion, Semen Cuscutae 28 weight portion ~ 32 weight portion, Semen Euryales 23 weight portion ~ 27 weight portion, Galla Chinensis 23 weight portion ~ 27 weight portion, Radix Asparagi 28 weight portion ~ 32 weight portion, Radix Adenophorae 33 weight portion ~ 37 weight portion, Herba Caryopteridis Incanae 18 weight portion ~ 22 weight portion, horse sour jujube 13 weight portion ~ 17 weight portion, Semen Astragali Complanati 13 weight portion ~ 17 weight portion and Radix Glycyrrhizae 18 weight portion ~ 22 weight portion.
Wherein, the weight portion of each crude drug in Chinese herbal medicine of replenishing the calcium described in is respectively Fructus Psoraleae 45 weight portion, Fructus Corni 30 weight portion, Radix Cyathulae 25 weight portion, Radix Puerariae 15 weight portion, Herba Lamii Amplexicaulis 15 weight portion, Radix et Rhizoma Rhei Franzenbachii 20 weight portion, Caulis et folium cryptotaeniae japonicae 15 weight portion, Radix et Rhizoma Thalictri 15 weight portion, Herba Tagetis Patulae 15 weight portion, Fructus Gardeniae grandiflorae 20 weight portion, Semen Cuscutae 30 weight portion, Semen Euryales 25 weight portion, Galla Chinensis 25 weight portion, Radix Asparagi 30 weight portion, Radix Adenophorae 35 weight portion, Herba Caryopteridis Incanae 20 weight portion, horse sour jujube 15 weight portion, Semen Astragali Complanati 15 weight portion and Radix Glycyrrhizae 20 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese herbal medicine of replenishing the calcium, it comprises:
The first step, gets Fructus Psoraleae, Fructus Corni, Radix Cyathulae, Radix et Rhizoma Rhei Franzenbachii, Semen Cuscutae, Semen Euryales, Galla Chinensis, Radix Asparagi, Radix Adenophorae and Semen Astragali Complanati, pulverizes respectively, puts into ethanol and soaks, and heating and refluxing extraction 2 times, obtains the first powder;
Second step, pulverizes respectively by remaining crude drug, adopts carbon dioxide supercritical fluid extraction to extract, obtains the second powder;
3rd step, by the first powder and the mixing of the second powder, cross 100 mesh sieves, sieved powder is medicinal herb components of replenishing the calcium.
Wherein, the described first step is specially gets each crude drug and is ground into 60 order coarse powder respectively, mixes, obtain mixture, adding relative to the determining alcohol of mixture 5-10 times amount is soak 1 ~ 2 hour in 70% ~ 80% ethanol, heating extraction 2 times, each 1 ~ 2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100 ~ 120 orders filter, then are the ultrafiltration post ultrafiltration of 5000 ~ 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains and gets dry extract, and is ground into the first powder.
Wherein, described second step is specially and remaining crude drug is ground into 60 order coarse powder respectively, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 30 ~ 40Mpa, extraction temperature 30 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 50 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 40 ~ 50L per hour, extracting solution, get and extract concentrating under reduced pressure and obtain and get dry extract, be ground into the second powder.
Present invention also offers a kind of Calcium-supplementinhealth health food, it is characterized in that: comprise above-mentioned Chinese herbal medicine of replenishing the calcium.
Present invention also offers the above-mentioned application of Chinese herbal medicine in preparation Calcium-supplementinhealth health food of replenishing the calcium.
Beneficial effect of the present invention:
Chinese herbal medicine is applied to edible biscuits by the present invention, is made into health food, makes full use of the effect of supplemented calcium of medicinal herb components, improves the bone density of patients with osteoporosis, thus plays function of resisting osteoporosis.
Detailed description of the invention
The invention provides one to replenish the calcium medicinal herb components, its raw material comprises: Fructus Psoraleae, Fructus Corni, Radix Cyathulae, Radix Puerariae, Herba Lamii Amplexicaulis, Radix et Rhizoma Rhei Franzenbachii, Caulis et folium cryptotaeniae japonicae, Radix et Rhizoma Thalictri, Herba Tagetis Patulae, Fructus Gardeniae grandiflorae, Semen Cuscutae, Semen Euryales, Galla Chinensis, Radix Asparagi, Radix Adenophorae, Herba Caryopteridis Incanae, horse sour jujube, Semen Astragali Complanati and Radix Glycyrrhizae.
Further preferably, medicinal herb components of replenishing the calcium described in is only prepared from by above-mentioned raw materials medicine.
Fang Zhong, Fructus Psoraleae kidney invigorating and YANG supporting, warming spleen and stopping diarrha, mesangial cell can be strengthened and promote osteoblastic proliferation and secreting alkaline phosphorus phytase, the function of osteopontin, Fructus Corni nourishing kidney-yin replenishing essence marrow, Radix Cyathulae can suppress bone resorption, reduce bone conversion, the ability of secreting type i collagen can be strengthened by stimulating osteoblast reproduction restraint in vitro, Radix Puerariae has the minimizing bone resorption of estrogen-like, promoting bone growing, increase the effect of bone density, Herba Lamii Amplexicaulis promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling, by improving alkaline phosphatase activities, promote osteoblastic proliferation, the formation of bone, suppress the bone resorption of osteoclast, body bone metabolism is played regulatory role, Radix et Rhizoma Rhei Franzenbachii can increase bone density, improve skeleton external force resistance, regulate blood calcium, parathyroid gland, alkaline phosphatase levels, promoting bone growing, suppress bone resorption, Caulis et folium cryptotaeniae japonicae blood-activating analgetic, by suppressing the differentiation of osteoclast, ripe, suppress bone resorption, Radix et Rhizoma Thalictri heat clearing and damp drying, eliminating fire and detoxication, its effective ingredient is combined with androgen receptor, play and intend androgen effect, thus suppress bone resorption and promote osteogenesis, improve bone density, Herba Tagetis Patulae clearing away heat-damp and promoting diuresis, the proliferation and function of osteoclast can be stimulated to express, Fructus Gardeniae grandiflorae reducing swelling and alleviating pain, can express by reinforced collagen, Herba Polygoni Capitati promoting blood circulation and detoxication, there is certain phytoestrogen effect, Semen Cuscutae effective ingredient significantly can promote that the osteogenic of mesenchymal stem cells MSCs breaks up, Semen Euryales supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, Galla Chinensis astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, hemostasis removing toxic substances, Radix Asparagi nourishing YIN and clearing away lung-heat, Radix Adenophorae nourishing the stomach to promote the production of body fluid, can promote that mesenchymal cell is to osteoblast system and the differentiation of chondroblast system, and its synthesizing activity can be promoted, Herba Caryopteridis Incanae dehumidifying dissipating blood stasis, horse sour jujube dissipating blood stasis removing food stagnancy, Rhizoma Chuanxiong blood-activating and qi-promoting, Semen Astragali Complanati temperature compensation Liver and kidney, blood calcium can be made, serium inorganic phosphorus, bone calcium, bone phosphorus and bone collagen content increase, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines share, play invigorating the kidney and strengthening the bones altogether, invigorating the spleen and benefiting QI, the merit of promoting blood circulation to remove obstruction in the collateral.
Each crude drug pharmacology is as follows:
Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, enter kidney, spleen channel, have kidney invigorating and YANG supporting, warming spleen and stopping diarrha effect, is mainly used in decline of the fire from the gate of life, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea; Insufficiency of kidney-YANG, spleen soil loses using warming therapy stomachache limb and trembles with fear, and Diarrhoea, Fructus Psoraleae also has the effect of antidiarrheal.
Fructus Corni: latin name corni fructus, sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat such as to be quenched one's thirst at the card.
Radix Cyathulae: sweet in the mouth, micro-hardship, property is put down, and enters liver, kidney channel, has the effect of blood circulation promoting and blood stasis dispelling, sharp joint, strong waist knee joint, inducing diuresis for treating stranguria syndrome, for blood stasis amenorrhea, dysmenorrhea, treating swelling and pain by traumatic injury, Fengshi Guanjie pain, with the passing of time soreness of the waist and knees, the cards such as pyretic stranguria, stranguria with blood, hematuria.
Radix Puerariae: latin name Puerariae Lobatae Radix, sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, have inspiration gastric qi, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, and raw sun, oozes the effect of rash, be mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and calentura is thirsty, quenches one's thirst; Diarrhea due to hypofunction of the spleen, the cards such as clear YANG failing to ascend.
Herba Lamii Amplexicaulis: be the herb of Labiatae lamium plant Herba Lamii Amplexicaulis, acrid in the mouth, hardship, slightly warm in nature, has promoting blood circulation to remove obstruction in the collateral, and effect of removing toxic substances and promoting subsidence of swelling, cures mainly traumatic injury, bones and muscles pain, numb limbs and tense tendons, hemiplegia, facial paralysis, jaundice, nasal sinusitis, toxic swelling, the cards such as impetigo.
Radix et Rhizoma Rhei Franzenbachii: latin name Radix et Rhizome Rhei Franzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter in the mouth; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of removing heat from blood clots absorbing, cures mainly jaundice due to damp-heat; Dysentery; Amenorrhea is suffered from abdominal pain; Hematemesis and epistaxis; Traumatic injury stasis of blood pain; Carbuncle furunculosis; Aphthous stomatitis; The cards such as burn and scald.
Caulis et folium cryptotaeniae japonicae: acrid in the mouth is bitter; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; Effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, gonorrhea, hernia, acute toothache, and carbuncle furuncle swells, herpes zoster, the cards such as skin pruritus.
Radix et Rhizoma Thalictri: be the root and rhizome of Ranunculaceae thalictrum spp spun gold Radix et Rhizoma Thalictri, Zhaotong Thalictrum aquilegifolium L. var. sibiricum Regel, plateau Thalictrum aquilegifolium L. var. sibiricum Regel, leafy Thalictrum aquilegifolium L. var. sibiricum Regel, bitter in the mouth, cold in nature, GUIXIN, liver, large intestine channel, there is heat clearing and damp drying, effect of eliminating fire and detoxication, cures mainly diarrhea due to damp-heat, dysentery, jaundice, cold, fever, measles, the cards such as conjunctival congestion and swelling pain.
Herba Tagetis Patulae: be the herb of Compositae plants of tagetes species Herba Tagetis Patulae, bitter in the mouth, property is put down, and have clearing away heat-damp and promoting diuresis, effect of cough-relieving pain relieving, cures mainly upper respiratory tract infection, dysentery, cough, pertussis, toothache, acute conjunctivitis due to pathogenic windfire, the cards such as mastitis.
Fructus Gardeniae grandiflorae: be the fruit of Rubiaceae Gardenia Ellis plant Flos Caryophylli Fructus Gardeniae, bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain, cure mainly pyretic toxicity, jaundice, oedema due to nephritis, dampen cards such as spraining.
Herba Polygoni Capitati: be the herb of Polygonaceae arsesmart Herba Polygoni Capitati, bitter in the mouth, pungent, cool in nature, have clearing away heat-damp and promoting diuresis, effect of promoting blood circulation and detoxication, cures mainly dysentery, pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, rheumatalgia, traumatic injury, skin infection, the cards such as eczema.
Semen Cuscutae: sweet in the mouth, pungent, property is put down, and enters liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity, be mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; To suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the symptoms such as aqueous-grainy diarrhea.
Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.
Galla Chinensis: sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, have hidroschesis of astringing the lung, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, effect of hemostasis removing toxic substances, cures mainly chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle.
Radix Asparagi: sweet in the mouth, hardship, cold in nature, return lung, kidney channel, there is nourishing YIN to relieve dryness, effect that lung heat clearing is promoted the production of body fluid, cures mainly cough caused by dryness-heat, deficiency of YIN chronic cough, hyperactivity of fire caused by deficiency of YIN, the laryngopharynx swelling and pain of the not solid seminal emission of kidney essense, premature ejaculation and hyperactivity of deficient fire, calentura Tianjin wound is thirsty, and interior-heat is quenched one's thirst the cards such as dryness of the intestine constipation.
Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enter lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, be mainly used in lung-dryness syndrome due to deficiency of YIN, dry cough few expectorant, chronic cough expectorant blood, the cards such as the few tongue of deficiency of stomach-Yin, mouthfeel parched throat, constipation, red tongue, cellular immunization and non-specific immunity can be improved, suppress humoral immunization, there is the function of immunity moderation balance.
Herba Caryopteridis Incanae: acrid in the mouth, warm in nature, there is cold relieving of inducing sweat, effect of dehumidifying dissipating blood stasis, cure mainly headche due to wind-cold flu, cough, pertussis, coldness and pain in the epigastrium, dyspeptic vomiting and diarrhea, cold stasis of blood dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, anemofrigid-damp arthralgia, traumatic injury congestive edema, eczema, the cards such as snakebite.
Horse sour jujube: bitter in the mouth, puckery, property is put down, and have heat-clearing and toxic substances removing, effect of dissipating blood stasis removing food stagnancy, cures mainly anemopyretic cold, cough due to lung-heat, furuncle, acute mastitis, traumatic injury, dyspeptic abdominal distention, the cards such as venom.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, have blood-activating and qi-promoting, effect of wind-expelling pain-stopping, cures mainly menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; The cards such as ulcer sores.
Semen Astragali Complanati: warm in nature, sweet in the mouth, has temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, frequent micturition, or leukorrhagia, soreness of the waist and knees, lumbago; Deficiency of the liver and kindey, blurred vision order is dark, the cards such as visual deterioration.
Radix Glycyrrhizae: latin name Glycyrrhizae Radix et Rhizoma, sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the work of each component.
In described medicinal herb components of replenishing the calcium, the weight portion of each crude drug is respectively Fructus Psoraleae 40 weight portion ~ 50 weight portion, Fructus Corni 25 weight portion ~ 35 weight portion, Radix Cyathulae 20 weight portion ~ 30 weight portion, Radix Puerariae 10 weight portion ~ 20 weight portion, Herba Lamii Amplexicaulis 10 weight portion ~ 20 weight portion, Radix et Rhizoma Rhei Franzenbachii 15 weight portion ~ 25 weight portion, Caulis et folium cryptotaeniae japonicae 10 weight portion ~ 20 weight portion, Radix et Rhizoma Thalictri 10 weight portion ~ 20 weight portion, Herba Tagetis Patulae 10 weight portion ~ 20 weight portion, Fructus Gardeniae grandiflorae 15 weight portion ~ 25 weight portion, Semen Cuscutae 25 weight portion ~ 35 weight portion, Semen Euryales 20 weight portion ~ 30 weight portion, Galla Chinensis 20 weight portion ~ 30 weight portion, Radix Asparagi 25 weight portion ~ 35 weight portion, Radix Adenophorae 30 weight portion ~ 40 weight portion, Herba Caryopteridis Incanae 15 weight portion ~ 25 weight portion, horse sour jujube 10 weight portion ~ 20 weight portion, Semen Astragali Complanati 10 weight portion ~ 20 weight portion and Radix Glycyrrhizae 15 weight portion ~ 25 weight portion.
Further, in described medicinal herb components of replenishing the calcium, the weight portion of each crude drug is respectively Fructus Psoraleae 43 weight portion ~ 47 weight portion, Fructus Corni 28 weight portion ~ 32 weight portion, Radix Cyathulae 23 weight portion ~ 27 weight portion, Radix Puerariae 13 weight portion ~ 17 weight portion, Herba Lamii Amplexicaulis 13 weight portion ~ 17 weight portion, Radix et Rhizoma Rhei Franzenbachii 18 weight portion ~ 22 weight portion, Caulis et folium cryptotaeniae japonicae 13 weight portion ~ 17 weight portion, Radix et Rhizoma Thalictri 13 weight portion ~ 17 weight portion, Herba Tagetis Patulae 13 weight portion ~ 17 weight portion, Fructus Gardeniae grandiflorae 18 weight portion ~ 22 weight portion, Semen Cuscutae 28 weight portion ~ 32 weight portion, Semen Euryales 23 weight portion ~ 27 weight portion, Galla Chinensis 23 weight portion ~ 27 weight portion, Radix Asparagi 28 weight portion ~ 32 weight portion, Radix Adenophorae 33 weight portion ~ 37 weight portion, Herba Caryopteridis Incanae 18 weight portion ~ 22 weight portion, horse sour jujube 13 weight portion ~ 17 weight portion, Semen Astragali Complanati 13 weight portion ~ 17 weight portion and Radix Glycyrrhizae 18 weight portion ~ 22 weight portion.
Most preferably, the weight portion of each crude drug in medicinal herb components of replenishing the calcium described in is respectively Fructus Psoraleae 45 weight portion, Fructus Corni 30 weight portion, Radix Cyathulae 25 weight portion, Radix Puerariae 15 weight portion, Herba Lamii Amplexicaulis 15 weight portion, Radix et Rhizoma Rhei Franzenbachii 20 weight portion, Caulis et folium cryptotaeniae japonicae 15 weight portion, Radix et Rhizoma Thalictri 15 weight portion, Herba Tagetis Patulae 15 weight portion, Fructus Gardeniae grandiflorae 20 weight portion, Semen Cuscutae 30 weight portion, Semen Euryales 25 weight portion, Galla Chinensis 25 weight portion, Radix Asparagi 30 weight portion, Radix Adenophorae 35 weight portion, Herba Caryopteridis Incanae 20 weight portion, horse sour jujube 15 weight portion, Semen Astragali Complanati 15 weight portion and Radix Glycyrrhizae 20 weight portion.
Present invention also offers the preparation method of above-mentioned medicinal herb components of replenishing the calcium, it comprises:
The first step, gets Fructus Psoraleae, Fructus Corni, Radix Cyathulae, Radix et Rhizoma Rhei Franzenbachii, Semen Cuscutae, Semen Euryales, Galla Chinensis, Radix Asparagi, Radix Adenophorae and Semen Astragali Complanati, pulverizes respectively, puts into ethanol and soaks, and heating and refluxing extraction 2 times, obtains the first powder;
Second step, pulverizes respectively by remaining crude drug, adopts carbon dioxide supercritical fluid extraction to extract, obtains the second powder;
3rd step, by the first powder and the mixing of the second powder, cross 100 mesh sieves, sieved powder is medicinal herb components of replenishing the calcium.
The described first step is specially gets each crude drug and is ground into 60 order coarse powder respectively, mix, obtain mixture, adding relative to the determining alcohol of mixture 5-10 times amount is soak 1 ~ 2 hour in 70% ~ 80% ethanol, heating extraction 2 times, each 1 ~ 2 hour, merge extractive liquid, removed supernatant after leaving standstill, then 100 ~ 120 orders filter, be the ultrafiltration post ultrafiltration of 5000 ~ 10000 again through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains and gets dry extract, and is ground into the first powder.
Described second step is specially and remaining crude drug is ground into 60 order coarse powder respectively, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30 ~ 40Mpa, extraction temperature 30 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 50 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 40 ~ 50L per hour, obtains extracting solution, get and extract concentrating under reduced pressure and obtain and get dry extract, be ground into the second powder.
The invention provides a kind of calcium milk biscuit, its raw material comprises: medicinal herb components of replenishing the calcium, Self-raising flour, white sugar, butter, sodium bicarbonate, consumption ammonium bicarbonate, essence, milk powder and egg.
Further preferably, described calcium milk biscuit is only prepared from by above-mentioned raw materials.
In described calcium milk biscuit, the weight portion of each raw material is respectively medicinal herb components 10 weight portion ~ 20 weight portion of replenishing the calcium, Self-raising flour 450 weight portion ~ 550 weight portion, white sugar 100 weight portion ~ 150 weight portion, butter 70 weight portion ~ 80 weight portion, sodium bicarbonate 5 weight portion ~ 10 weight portion, consumption ammonium bicarbonate 10 weight portion ~ 20 weight portion, essence 0.5 weight portion ~ 1.5 weight portion, milk powder 10 weight portion ~ 20 weight portion and egg 15 weight portion ~ 20 weight portion.
Further preferably, in described calcium milk biscuit, the weight portion of each raw material is respectively medicinal herb components 15 weight portion of replenishing the calcium, Self-raising flour 500 weight portion, white sugar 130 weight portion, butter 75 weight portion, sodium bicarbonate 8 weight portion, consumption ammonium bicarbonate 15 weight portion, essence 1 weight portion, milk powder 15 weight portion and egg 18 weight portion.
Present invention also offers the preparation method of above-mentioned calcium milk biscuit, comprising:
The first step, prepares medicinal herb components of replenishing the calcium, for subsequent use;
Second step, flour sieving process, prevents from adjusting in powder process and lumps;
3rd step, after butter heating and melting, ambient temperatare is put to be cooled to and is slightly solidified, and beats to smooth, and color even, first white sugar is joined at twice in the butter beaten, white sugar is fully combined with butter, enlarged volume; Add egg again, beat to its volume fluffy, the white shape slightly white in color;
3rd step, after Self-raising flour, replenish the calcium medicinal herb components and milk powder mixing, joins in batches in the butter after whipping, stirs evenly at a slow speed, add sodium bicarbonate, consumption ammonium bicarbonate and essence subsequently further, continue to stir half an hour, obtain batter;
4th step, loads batter in mould, is squeezed on the baking tray of oiling, arranges the fire in a stove before fuel is added 150 DEG C, face fire 180 DEG C, comes out of the stove after baking 12min, and after product is come out of the stove, cooling 20min packs to room temperature again, and the sealing of room temperature lucifuge is preserved.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 is replenished the calcium medicinal herb components 1
Get Fructus Psoraleae 45g, Fructus Corni 30g, Radix Cyathulae 25g, Radix et Rhizoma Rhei Franzenbachii 20g, Semen Cuscutae 30g, Semen Euryales 25g, Galla Chinensis 25g, Radix Asparagi 30g, Radix Adenophorae 35g and Semen Astragali Complanati 15g, is ground into 60 order coarse powder respectively, mixes, obtain mixture, the determining alcohol adding 2.2kg is soak 2 hours in 80% ethanol, heating extraction 2 times, each 2 hours, merge extractive liquid, removes supernatant after leaving standstill, and then 100 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains and gets dry extract, and is ground into the first powder, by Radix Puerariae 15g, Herba Lamii Amplexicaulis 15g, Caulis et folium cryptotaeniae japonicae 15g, Radix et Rhizoma Thalictri 15g, Herba Tagetis Patulae 15g, Fructus Gardeniae grandiflorae 20g, Herba Caryopteridis Incanae 20g, horse sour jujube 15g, be ground into 60 order coarse powder respectively with Radix Glycyrrhizae 20g, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 15Mpa, separator temperature 60 DEG C, disengaging time 3 hours, carbon dioxide flow 40L per hour, obtains extracting solution, gets to extract concentrating under reduced pressure and obtain and get dry extract, be ground into the second powder, by the first powder and the mixing of the second powder, cross 100 mesh sieves, sieved powder is medicinal herb components 1 of replenishing the calcium.
Embodiment 2 is replenished the calcium medicinal herb components 2
Get Fructus Psoraleae 43g, Fructus Corni 28g, Radix Cyathulae 23g, Radix et Rhizoma Rhei Franzenbachii 18g, Semen Cuscutae 28g, Semen Euryales 23g, Galla Chinensis 23g, Radix Asparagi 28g, Radix Adenophorae 33g and Semen Astragali Complanati 13g, is ground into 60 order coarse powder respectively, mixes, obtain mixture, the determining alcohol adding 2.2kg is soak 2 hours in 80% ethanol, heating extraction 2 times, each 2 hours, merge extractive liquid, removes supernatant after leaving standstill, and then 100 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains and gets dry extract, and is ground into the first powder, by Radix Puerariae 13g, Herba Lamii Amplexicaulis 13g, Caulis et folium cryptotaeniae japonicae 13g, Radix et Rhizoma Thalictri 13g, Herba Tagetis Patulae 13g, Fructus Gardeniae grandiflorae 18g, Herba Caryopteridis Incanae 18g, horse sour jujube 13g, be ground into 60 order coarse powder respectively with Radix Glycyrrhizae 18g, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 15Mpa, separator temperature 60 DEG C, disengaging time 3 hours, carbon dioxide flow 40L per hour, obtains extracting solution, gets to extract concentrating under reduced pressure and obtain and get dry extract, be ground into the second powder, by the first powder and the mixing of the second powder, cross 100 mesh sieves, sieved powder is medicinal herb components 2 of replenishing the calcium.
Embodiment 3 is replenished the calcium medicinal herb components 3
Get Fructus Psoraleae 47g, Fructus Corni 32g, Radix Cyathulae 27g, Radix et Rhizoma Rhei Franzenbachii 22g, Semen Cuscutae 32g, Semen Euryales 27g, Galla Chinensis 27g, Radix Asparagi 32g, Radix Adenophorae 37g and Semen Astragali Complanati 17g, is ground into 60 order coarse powder respectively, mixes, obtain mixture, the determining alcohol adding 2.2kg is soak 2 hours in 80% ethanol, heating extraction 2 times, each 2 hours, merge extractive liquid, removes supernatant after leaving standstill, and then 100 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains and gets dry extract, and is ground into the first powder, by Radix Puerariae 17g, Herba Lamii Amplexicaulis 17g, Caulis et folium cryptotaeniae japonicae 17g, Radix et Rhizoma Thalictri 17g, Herba Tagetis Patulae 17g, Fructus Gardeniae grandiflorae 22g, Herba Caryopteridis Incanae 22g, horse sour jujube 17g, be ground into 60 order coarse powder respectively with Radix Glycyrrhizae 22g, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 15Mpa, separator temperature 60 DEG C, disengaging time 3 hours, carbon dioxide flow 40L per hour, obtains extracting solution, gets to extract concentrating under reduced pressure and obtain and get dry extract, be ground into the second powder, by the first powder and the mixing of the second powder, cross 100 mesh sieves, sieved powder is medicinal herb components 3 of replenishing the calcium.
Embodiment 4 toxicology test
Acute toxicity test: cleaning grade male and female mice is divided into administration group and matched group at random, the medicinal herb components 1 of replenishing the calcium of administration group feed embodiment 1 preparation, be dissolved in water and be configured to maximum administration concentration, 2.5g crude drug/ml, 90ml/kg, matched group feed disinfectant, 90ml/kg, divide equally three administrations feedwater, within every 4 hours, be administered once, normal breeding observing one week.During administration feedwater, each group mice behavioral activity is normal, has no movable and reduces, rolls up, the phenomenon such as Folium Pini, and nose, eye, oral cavity have no secretions, none dead mouse.The maximum dosage of mice is 260g crude drug/kg body weight.The above results shows, when the maximum dosage of mice is 260g crude drug/kg, drug regimen of the present invention has no acute toxic reaction.
Long term toxicity test: observe medicinal herb components 1 gavage 180 days body weight on rat, hematological indices, serological biochemical markers and Main Organ Coefficients and histological impact continuously of replenishing the calcium prepared by embodiment 1.Cleaning grade male and female rat is divided into large, medium and small administration group and Normal group at random.Large, medium and small administration group dosage is respectively 80,50,25g crude drug/kg/d.Continuous oral administration 180 days.Experimental result shows, during administration, the behavior of each group rat outward appearance, body weight, food-intake are all normal, has no movable and reduces, rolls up, the phenomenon such as Folium Pini, and nose, eye, oral cavity have no secretions; When routine blood test [RBC, HGB, HCT, PLT, WBC and classification (LYM, MID, GRA) thereof], blood coagulation, (CT) is all normal.Biochemical indicator: comprise liver function (AST, ALT), renal function (BUN, Crea), alkali phosphatase (ALP), total serum protein (TP), albumin (ALB) and cholesterol (TC), blood glucose (GLU), 90 days upon administration, 180 days compared with corresponding matched group, all within the scope of normal variation, have no significant change.Rat administration histoorgan (heart, liver,kidney,spleen, lung, adrenal gland, thymus, testis, epididymis, uterus and ovary, brain, stomach, pancreas, thyroid) organ index of two weeks after 90,180 days and after drug withdrawal, visual inspection and Histological section check and are showed no obvious pathological change.The above results shows, the present invention replenish the calcium medicinal herb components 80g crude drug/kg, 50g crude drug/kg and 25g crude drug/kg successive administration within 6 months, have no overt toxicity reaction.
Embodiment 5 calcium milk biscuit
5kg Self-raising flour sieves process, prevents from adjusting in powder process luming, and after getting 0.75kg butter heating and melting, ambient temperatare is put to be cooled to and slightly solidified, beat to smooth, and color even, first 1.3kg white sugar is joined at twice in the butter beaten, white sugar is fully combined, enlarged volume with butter, add 0.18kg egg again, beat fluffy to its volume, the white shape slightly white in color, by 5kg Self-raising flour, 0.15kg prepared by embodiment 1 replenishes the calcium after medicinal herb components 1 and the mixing of 0.15kg milk powder, join in the butter after whipping in batches, stir evenly at a slow speed, add 0.08kg sodium bicarbonate further subsequently, 0.15kg consumption ammonium bicarbonate and 0.01kg essence, continue to stir half an hour, obtain batter, batter is loaded in mould, be squeezed on the baking tray of oiling, the fire in a stove before fuel is added 150 DEG C is set, face fire 180 DEG C, come out of the stove after baking 12min, after product is come out of the stove, cooling 20min packs to room temperature again, the sealing of room temperature lucifuge is preserved.
Embodiment 6 is replenished the calcium test
1, laboratory animal
Select healthy SPF level female sd inbred rats 120, body weight 250 ~ 270g, 4.5 monthly ages, not copulation.Grouping: first separating 1 at random for normal group before modeling, is 30 rats; Oophorectomize group survivor was divided into 3 groups (often organize 30) at random by body weight in postoperative 7 days, that is: 2 be the blank matched group of model, 3 be calcium milk biscuit group, 4 be Gaierqi D (vitamin D3 and calcium carbonate)
600positive drug control group.
2, medicine and reagent
Gaierqi D (vitamin D3 and calcium carbonate)
600, Hui Shi-hundred palace pharmaceutical Co. Ltd product;
Calcium milk biscuit prepared by embodiment 5;
Tartrate resistant acid phosphatase (TRAP) testing cassete, is purchased from Nanjing and builds up bioengineering product company;
BGP content ELISA kit, is purchased from Japanese TAKARA Biological Co., Ltd.
Acrylamide; Methylene-bisacrylamide; Dodecyl sodium sulfate; TEMED; Ethidium bromide, Sigma Products; Glycine, GIBCO Products; Ammonium Persulfate 98.5, A.P.U Products; Boric acid, BBI Products; Tris, BBI Products; Sodium bicarbonate (NaHCO
3), hydrochloric acid (HCl), sodium hydroxide (NaOH), Na
2hPO
412H
2o, NaH
2pO
42H
2o, Tween 20, chloroform, isopropyl alcohol, dehydrated alcohol, EDTA etc. are domestic analytical pure.
3, key instrument
XR-36 type Dual-energy X-rays absorptionmetry, U.S. NORLAND Products; DU640 nucleic acid-protein analyser, U.S. Beckman Products; 550 type microwell plate microplate reader, the place of production U.S.; BT-31 water bath with thermostatic control shaker, Japanese KAMAMOTO Products; MR1822 low-temperature and high-speed centrifuge, French Jouan Products; MODEL 250 electrophresis apparatus, U.S. GIBCO BRL Products; Milli-Q Biocel ultrapure water machine, French MILLIPORE product; Heidolph DIAX90 type refiner, German Heidolph Products.
4, Testing index and method
Bone density index
The mensuration of bone density (BMD), adopts Dual X-ray method (DEXA) to measure whole section of rat femur and femoral head BMD.Get rat left hind femur, reject the muscular fascia of attachment, retain periosteum, use NOR-LAND company XR-36 type Dual-energy X-rays absorptionmetry, adopt toy bone densitometry software, measure rat left hind femur and capital bone density (g/cm
2).
Biochemical markers of bone metabolism
Bone resorption marker: serum Tartrate resistant acid phosphatase (TRAP) measures and adopts enzyme process, and device therefor is DU640 nucleic acid-protein analyser, and TRAP test kit is purchased from Nanjing and builds up biological product company.
Bone formation index: Bone Gla protein (BGP).Enzyme-linked immunoassay method (ELISA method) is adopted to measure.
5, modeling
Except normal group, remaining person carries out modeling process, rat is anaesthetized through lumbar injection ketalar 0.2mL/250g, it is fixed on self-control operation bracket with front lying position, top about 1cm from rat crista iliaca top, lumbar vertebra musculus sacrospinalis both sides approach for resection rats with bilateral ovary, postoperative muscle injection penicillin 0.4mL/250g, continuous 3d modeling.
6, statistical method
Adopt SPSS 11.0 systems soft ware process data, measurement data is used
represent, compare employing one factor analysis of variance between group, enumeration data adopts χ
2inspection, P < 0.05 has statistical significance for difference.
7, result
The result of bone density change, in table 1.
Table 1 calcium milk biscuit is on the impact of rat bone density
| Group | n | Femoral bmd | Femoral head 1/3 bone density |
| Normal group | 30 | 0.183±0.021 | 0.188±0.015 |
| Model control group | 30 | 0.121±0.013 | 0.129±0.017 |
| Calcium milk biscuit group | 30 | 0.191±0.008 | 0.193±0.012 |
| Gaierqi D (vitamin D3 and calcium carbonate) 600Group | 30 | 0.153±0.011 | 0.157±0.015 |
From table 1, after feeding 12w, take Gaierqi D (vitamin D3 and calcium carbonate)
600all femur, capital bone density value obviously can be increased with calcium milk biscuit provided by the invention.The wherein bone density prompting of femur: calcium milk biscuit can reach the bone density value of normal rat, and its effect is better than Gaierqi D (vitamin D3 and calcium carbonate)
600group, significant difference (P < 0.05).Capital bone density prompting: calcium milk biscuit can reach the bone density value of normal rat, and its effect is better than Gaierqi D (vitamin D3 and calcium carbonate)
600group, significant difference (P < 0.05).
Serum Tartrate resistant acid phosphatase (TRAP) content detection result, the results are shown in Table 2.
Table 2 calcium milk biscuit is on the impact of rat blood serum acid phosphatase
| Group | n | Phosphatase acid serum (μ/L) |
| Normal group | 30 | 6.982±1.021 |
| Model control group | 30 | 18.359±1.681 |
| Calcium milk biscuit group | 30 | 12.915±1.539 |
| Gaierqi D (vitamin D3 and calcium carbonate) 600Group | 30 | 14.013±1.298 |
From table 2, model control group compared with normal group phosphatase acid serum content significantly rises, significant difference (P < 0.05), compared with model control group, calcium milk biscuit provided by the invention is adopted can significantly to reduce phosphatase acid serum content, significant difference (P < 0.05).
Serum osteocalcin content detection result, the results are shown in Table 3.
Table 3 calcium milk biscuit is on the impact of serum calcium cellulose content
| Group | n | Serum osteocalcin content (ng/mL) |
| Normal group | 30 | 873.000±92.217 |
| Model control group | 30 | 525.000±83.597 |
| Calcium milk biscuit group | 30 | 733.250±89.166 |
| Gaierqi D (vitamin D3 and calcium carbonate) 600Group | 30 | 632.500±87.267 |
Compare with normal group, model group BGP content is starkly lower than matched group (P < 0.01), and adopts calcium milk biscuit provided by the invention obviously can promote the level of BGP content.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. the Chinese herbal medicine of replenishing the calcium in a health food, it is characterized in that, crude drug comprises: Fructus Psoraleae, Fructus Corni, Radix Cyathulae, Radix Puerariae, Herba Lamii Amplexicaulis, Radix et Rhizoma Rhei Franzenbachii, Caulis et folium cryptotaeniae japonicae, Radix et Rhizoma Thalictri, Herba Tagetis Patulae, Fructus Gardeniae grandiflorae, Semen Cuscutae, Semen Euryales, Galla Chinensis, Radix Asparagi, Radix Adenophorae, Herba Caryopteridis Incanae, horse sour jujube, Semen Astragali Complanati and Radix Glycyrrhizae.
2. to replenish the calcium as claimed in claim 1 Chinese herbal medicine, it is characterized in that: the weight portion of each crude drug is respectively Fructus Psoraleae 40 weight portion ~ 50 weight portion, Fructus Corni 25 weight portion ~ 35 weight portion, Radix Cyathulae 20 weight portion ~ 30 weight portion, Radix Puerariae 10 weight portion ~ 20 weight portion, Herba Lamii Amplexicaulis 10 weight portion ~ 20 weight portion, Radix et Rhizoma Rhei Franzenbachii 15 weight portion ~ 25 weight portion, Caulis et folium cryptotaeniae japonicae 10 weight portion ~ 20 weight portion, Radix et Rhizoma Thalictri 10 weight portion ~ 20 weight portion, Herba Tagetis Patulae 10 weight portion ~ 20 weight portion, Fructus Gardeniae grandiflorae 15 weight portion ~ 25 weight portion, Semen Cuscutae 25 weight portion ~ 35 weight portion, Semen Euryales 20 weight portion ~ 30 weight portion, Galla Chinensis 20 weight portion ~ 30 weight portion, Radix Asparagi 25 weight portion ~ 35 weight portion, Radix Adenophorae 30 weight portion ~ 40 weight portion, Herba Caryopteridis Incanae 15 weight portion ~ 25 weight portion, horse sour jujube 10 weight portion ~ 20 weight portion, Semen Astragali Complanati 10 weight portion ~ 20 weight portion and Radix Glycyrrhizae 15 weight portion ~ 25 weight portion.
3. to replenish the calcium as claimed in claim 1 or 2 Chinese herbal medicine, it is characterized in that: the weight portion of each crude drug is respectively Fructus Psoraleae 43 weight portion ~ 47 weight portion, Fructus Corni 28 weight portion ~ 32 weight portion, Radix Cyathulae 23 weight portion ~ 27 weight portion, Radix Puerariae 13 weight portion ~ 17 weight portion, Herba Lamii Amplexicaulis 13 weight portion ~ 17 weight portion, Radix et Rhizoma Rhei Franzenbachii 18 weight portion ~ 22 weight portion, Caulis et folium cryptotaeniae japonicae 13 weight portion ~ 17 weight portion, Radix et Rhizoma Thalictri 13 weight portion ~ 17 weight portion, Herba Tagetis Patulae 13 weight portion ~ 17 weight portion, Fructus Gardeniae grandiflorae 18 weight portion ~ 22 weight portion, Semen Cuscutae 28 weight portion ~ 32 weight portion, Semen Euryales 23 weight portion ~ 27 weight portion, Galla Chinensis 23 weight portion ~ 27 weight portion, Radix Asparagi 28 weight portion ~ 32 weight portion, Radix Adenophorae 33 weight portion ~ 37 weight portion, Herba Caryopteridis Incanae 18 weight portion ~ 22 weight portion, horse sour jujube 13 weight portion ~ 17 weight portion, Semen Astragali Complanati 13 weight portion ~ 17 weight portion and Radix Glycyrrhizae 18 weight portion ~ 22 weight portion.
4. the Chinese herbal medicine of replenishing the calcium as described in claims 1 to 3, it is characterized in that: the weight portion of each crude drug is respectively Fructus Psoraleae 45 weight portion, Fructus Corni 30 weight portion, Radix Cyathulae 25 weight portion, Radix Puerariae 15 weight portion, Herba Lamii Amplexicaulis 15 weight portion, Radix et Rhizoma Rhei Franzenbachii 20 weight portion, Caulis et folium cryptotaeniae japonicae 15 weight portion, Radix et Rhizoma Thalictri 15 weight portion, Herba Tagetis Patulae 15 weight portion, Fructus Gardeniae grandiflorae 20 weight portion, Semen Cuscutae 30 weight portion, Semen Euryales 25 weight portion, Galla Chinensis 25 weight portion, Radix Asparagi 30 weight portion, Radix Adenophorae 35 weight portion, Herba Caryopteridis Incanae 20 weight portion, horse sour jujube 15 weight portion, Semen Astragali Complanati 15 weight portion and Radix Glycyrrhizae 20 weight portion.
5. to replenish the calcium described in Claims 1-4 the preparation method of Chinese herbal medicine, it is characterized in that, comprising:
The first step, gets Fructus Psoraleae, Fructus Corni, Radix Cyathulae, Radix et Rhizoma Rhei Franzenbachii, Semen Cuscutae, Semen Euryales, Galla Chinensis, Radix Asparagi, Radix Adenophorae and Semen Astragali Complanati, pulverizes respectively, puts into ethanol and soaks, and heating and refluxing extraction 2 times, obtains the first powder;
Second step, pulverizes respectively by remaining crude drug, adopts carbon dioxide supercritical fluid extraction to extract, obtains the second powder;
3rd step, by the first powder and the mixing of the second powder, cross 100 mesh sieves, sieved powder is medicinal herb components of replenishing the calcium.
6. to replenish the calcium as claimed in claim 5 the preparation method of Chinese herbal medicine, it is characterized in that: the described first step is specially gets each crude drug and be ground into 60 order coarse powder respectively, mix, obtain mixture, adding relative to the determining alcohol of mixture 5-10 times amount is soak 1 ~ 2 hour in 70% ~ 80% ethanol, heating extraction 2 times, each 1 ~ 2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100 ~ 120 orders filter, then are the ultrafiltration post ultrafiltration of 5000 ~ 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains and gets dry extract, and is ground into the first powder.
7. the preparation method of the Chinese herbal medicine of replenishing the calcium as described in claim 5 or 6, it is characterized in that: described second step is specially and remaining crude drug is ground into 60 order coarse powder respectively, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30 ~ 40Mpa, extraction temperature 30 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 50 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 40 ~ 50L per hour, extracting solution, get and extract concentrating under reduced pressure and obtain and get dry extract, be ground into the second powder.
8. a Calcium-supplementinhealth health food, is characterized in that: comprise the Chinese herbal medicine of replenishing the calcium described in Claims 1-4.
9. Chinese herbal medicine of replenishing the calcium described in Claims 1-4 is preparing the application in Calcium-supplementinhealth health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510173143.7A CN104800532A (en) | 2015-04-13 | 2015-04-13 | Calcium supplementing substances used in health food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510173143.7A CN104800532A (en) | 2015-04-13 | 2015-04-13 | Calcium supplementing substances used in health food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104800532A true CN104800532A (en) | 2015-07-29 |
Family
ID=53686015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510173143.7A Pending CN104800532A (en) | 2015-04-13 | 2015-04-13 | Calcium supplementing substances used in health food |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104800532A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001001996A1 (en) * | 1999-06-29 | 2001-01-11 | University Of Western Australia | Compositions and methods for treating or preventing osteoporosis |
| CN1695714A (en) * | 2005-05-08 | 2005-11-16 | 杨荣平 | Combination of medication for treating osteoporosis and preparation method |
| CN102614250A (en) * | 2012-04-09 | 2012-08-01 | 赵全成 | Natural medicine composition capable of increasing bone density and preventing and treating osteoporosis |
-
2015
- 2015-04-13 CN CN201510173143.7A patent/CN104800532A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001001996A1 (en) * | 1999-06-29 | 2001-01-11 | University Of Western Australia | Compositions and methods for treating or preventing osteoporosis |
| CN1695714A (en) * | 2005-05-08 | 2005-11-16 | 杨荣平 | Combination of medication for treating osteoporosis and preparation method |
| CN102614250A (en) * | 2012-04-09 | 2012-08-01 | 赵全成 | Natural medicine composition capable of increasing bone density and preventing and treating osteoporosis |
Non-Patent Citations (3)
| Title |
|---|
| 张鼎林等: "《骨质疏松症患者的家庭养护》", 31 October 2007, 科学技术文献出版社 * |
| 徐军: "《骨质疏松症防治问答》", 31 March 2013, 金盾出版社 * |
| 沈霖: "《骨质疏松症》", 31 January 2010, 中国医药科技出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102886038B (en) | Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation | |
| CN101797326B (en) | Chinese materia medica preparation for treating borborygmus diarrhoea and preparation method thereof | |
| CN104606612A (en) | Alcohol-expelling kidney-tonifying tablet candy and preparation method thereof | |
| CN105695258A (en) | Female health wine containing lychee seed saponin | |
| CN104738136A (en) | Calcium milk biscuit | |
| CN101628068A (en) | Pharmaceutical composition for treating juvenile poliosis and preparation method thereof | |
| CN107822040A (en) | A kind of preparation method of rhizoma zingiberis cinnamon health care jelly | |
| CN103690919A (en) | Medicine for treating piglet iron-deficiency anemia and preparation method of medicine | |
| CN106605915A (en) | Intestine-lubricating and bowel-relaxing health-care food for the aged and preparation method thereof | |
| CN104398991A (en) | Medicinal composition for treating hypogalactia symptom of dairy cow and preparation method thereof | |
| CN103239680A (en) | Traditional Chinese medicine for treating fatty liver syndrome in chicken | |
| CN104825855A (en) | Anti-ageing traditional Chinese medicinal composition and preparation method thereof | |
| CN105963648A (en) | Formula of paste for treating asthma diseases, as well as preparation method and application thereof | |
| CN103520302B (en) | Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof | |
| CN110433250A (en) | A kind of tonifying kidney and strengthening yang Chinese medicine composition and preparation method thereof | |
| CN103330837B (en) | Traditional Chinese medicine composition for curing osteoporosis of menopausal women | |
| CN106472680A (en) | A kind of milk product | |
| CN104258199A (en) | Traditional Chinese medicinal composition for preventing and treating white muscle disease of sheep and preparation method thereof | |
| CN102614319B (en) | Medicinal composition for treating fracture healing | |
| CN105998640A (en) | Selenium germanium-enriched snake and turtle liquor | |
| CN105362682A (en) | External-use medicine for treating hypomenorrhea | |
| CN104800532A (en) | Calcium supplementing substances used in health food | |
| CN106620475B (en) | Traditional Chinese medicine composition for preventing and treating diabetes cognitive impairment and preparation method thereof | |
| CN104740404A (en) | Traditional Chinese medicine composition for treating lupus erythematosus | |
| CN103525649A (en) | Formula of kidney-tonifying and bone-strengthening black sesame wine and production method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150729 |