CN104740404A - Traditional Chinese medicine composition for treating lupus erythematosus - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating lupus erythematosus. The traditional Chinese medicine composition is prepared from the following raw herbal materials: rostrate lepidogrammitis, marigold inflorescence, many-nerved bauhinia root, grossedentate clematis root, stem and leaf of slender-spike gouania, Japanese spicebush bark, woolly lespedeza root, delavay schefflera root, indian abutilon root, Chinese mahonia leaf, sanchi flower, slender silene, false lily of the valley, oat grass, leonurus pseudomacranthus, ixora chinensis, suberect spatholobus stem and bunge bedstraw herb with effects of clearing away heat and toxic materials, clearing liver heat, cooling blood to remove stasis, and relaxing tendons and muscles, as well as excrementum pteropi, herb of white clover, flos sophorae, rosa taiwanensis, Chinese blister beetle, ophiopogon latifolius, lithospermum, radix achyranthis bidentatae, seed of Chinese dodder, raspberry, monkshood, rhododendron delavayi, lotus leaf, lotus plumule, grapes, mulberry, ginseng leaf, myrobalan, ginkgo leaf, greenish lily flower, albizia flower, peony and ginseng flower with effects of tonifying the kidneys and detoxifying, cooling blood to remove stasis, nourishing yin and tonifying yang, soothing the livers and benefiting qi, is remarkable in curative effect for lupus erythematosus, and can be used for supplementing qi of a human body, strengthening immunity and improving the effective rate of treating lupus erythematosus.
Description
Technical field
The present invention relates to Chinese medicine technical field, particularly relate to a kind of Chinese medicine composition being used for the treatment of lupus erythematosus and preparation method thereof.
Background technology
Lupus erythematosus (LE) is that a kind of typical autoimmune connective tissue is sick, is more common in 15 ~ 40 years old women.
With heating in various degree, the edematous erythema at Dermal exposure position, arthralgia, pars oralis pharyngis ulcer etc. is main clinical characteristics.Then there is pericarditis, myocarditis or endocarditis in Cardiac Involvemant, even heart failure etc.Then there are nephritis, nephrotic syndrome, renal insufficiency etc. in renal involvement.Digestive system is got involved, and occurs that hepatitis, gastroenteritic ulcer are hemorrhage etc.Then there are epilepsy, meningitis, cerebrovas-cularaccident etc. in neurological involvement.LE take young women as principal pathogenetic crowd.Acute onset is hurried, and with serious poisoning symptom, and multi viscera is got involved, nonfunction, and prognosis is poor.Chronic type plate-like is damaged, and pathological changes is confined to skin, seldom involves internal organs, and course advancement is slow, prognosis bona.
Traditional Chinese medicine does not propose the concept of " lupus erythematosus ".The nomenclature principle of traditional Chinese medical science disease mainly with the cause of disease, pathogenesis, pathological product, sick position, primary symptom, sign for foundation.LE belongs to the category such as " YIN YANG toxin syndrome ", " red butterfly sore ", " lantana ", " cardiopalmus ", " fever due to internal injury ", " arthromyodynia ", " edema ", " asthenia " of the traditional Chinese medical science.
[etiology and pathology]
The cause of disease of LE has endogenous cause of ill and exopathogenic factor two aspect.It is interior because natural endowment is not enough; Outer because daily life careless, sunlight exposure, the evil poison of impression, internal injury caused by excess of seven emotions, labor, for excessive etc., causes the imbalance of internal organs negative and positive of qi and blood, raw and fall ill in scorchingly hot and blood stasis.
Pathological change is excessive noxious heat, broadcasts bright nutrient blood, and damage blood network, be then shown in heating, and glossopharyngeum is burst pain, skin erythema, tells, vomits, urine, feces blood.The bright deficiency of YIN of heat, blood stasis network is empty, exopathogen numbness network, then arthralgia.Deficiency of YIN QI consumed, the evil malicious numbness heart, then shortness of breath and palpitation, uncomfortable in chest or pain, purple lip.Yin deficiency and blood stasis, then low grade fever, erythema color is dim.Damage of kidney-YIN gauge head is swooned, alopecia.Deficiency of YIN affecting YANG, deficiency of spleen-YANG and kidneyYANG, then edema of lower limbs, spinal column is aching and limp.In addition, feelings will internal injury, depression of liver-QI, hematogenous blockage, in ecchymosis, knot surveys the pain over the hypochondriac region with doing lower piece.
Modern medicine is also set forth clear to the basic pathogenesis of lupus erythematosus not yet completely, curative effect satisfied especially is not obtained in clinical treatment yet, still based on Supporting Therapy of suiting the medicine to the illness, although at present according to the research of modern molecular thing, have developed part to carry out offering sacriffices to the gods or the spirits of the dead the medicine to treatment for site morbidity link or mechanism, but the complexity of Pathogenesis of SLE mechanism, multiformity, often can not obtain satisfied therapeutic effect for a morbidity link or pathogenetic treatment separately.The action character of Chinese medicine to human body and disease is multicomponent, too many levels, offer sacriffices to the gods or the spirits of the dead point, integrally-regulated more, drug effect is played by comprehensive effect, can according to the different phase of the lupus erythematosus course of disease and pathogenetic multiformity, carry out for different emphasis and take into account many-sided treatment, thus compensate for many deficiencies of simple western medical treatment.And treat timely and effectively in early days in lupus erythematosus, can effectively block or delay the disease progression of lupus erythematosus, thus shorten the course of disease or gain time for treatment, on the basis that modern medicine infection, maintenance Efficient Cycle, Nutrition and Metabolism support and Intensive care are treated, positive performance Effect of Chinese Medicine Qing thermal detoxification, clear internal organs are captured, invigorating blood circulation is tired and the advantage of strengthening vital QI to eliminate pathogenic factors, will be conducive to improving clinical efficacy.The effect of therapy of combining Chinese and Western medicine lupus erythematosus is better than simple western medicine, is mainly manifested in and improves hemodynamics, increases microcirculatory perfusion, scavenging activated oxygen, reduces inflammatory factor level, promotes that each organ function recovers as early as possible, thus improve cure rate; And patient clinical symptom can be made to take a turn for the better or be clearly better, reduce complication, it is easy to operation, low cost, and during treatment, patient suffering is little, is easy to accept, and is easy to promote.
Therefore; the invention provides a kind of Chinese medicine composition being used for the treatment of lupus erythematosus; by coordinating traditional western medical treatment; can antagonism inflammatory mediator and endotoxic release effectively; better improve patients symptomatic; alleviate or suppress systemic inflammatory response, protect each tract function, improving the effective percentage for the treatment of lupus erythematosus.
Summary of the invention
Technical problem to be solved by this invention is; a kind of Chinese medicine composition being used for the treatment of lupus erythematosus is provided; by coordinating traditional western medical treatment; can antagonism inflammatory mediator and endotoxic release effectively; better improve patients symptomatic; alleviate or suppress systemic inflammatory response, protect each tract function, improving the effective percentage for the treatment of lupus erythematosus.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of lupus erythematosus, its crude drug comprises: above cough tree, Flos Tagetis Erectae inflorescence, Radix Bauhiniae pemervosae, Radix Clematidis Argentilucidae, Caulis et Folium (Gouaniae Leptostachyae), Cortex Linderae Obtusilobae, Radix Lespedezae Tomentosae, Radix Schefflerae Delavayi, Radix abutili indici, Folium Mahoniae, flower of Radix Notoginseng, Radix Silenes Tenuis, Herba Maianthemi Bifolii, Herba avenae fatuae, Herba leonuri pseudoma cranthi, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Caulis Spatholobi, Galium spurium L., Oletum Trogopterori, Herba Trifolii Pepentis, Flos Sophorae, Radix Rosae Cymosae, Mylabris, Radix Ophiopogonis Dracaenoidis, Radix Arnebiae (Radix Lithospermi), Radix Achyranthis Bidentatae, Semen Cuscutae, Fructus Rubi, Radix Aconiti Lateralis Preparata, Flos Rhododendri Delavayi, Folium Nelumbinis, Plumula Nelumbinis, Fructus Vitis viniferae, Fructus Mori, Folium Ginseng, Fructus chebulae immaturus, Folium Ginkgo, Flos Lilii viriduli, Flos Albiziae, Flos Moutan, Flos Ginseng.Tree is coughed wherein, Flos Tagetis Erectae inflorescence, Radix Bauhiniae pemervosae, Radix Clematidis Argentilucidae, Caulis et Folium (Gouaniae Leptostachyae), Cortex Linderae Obtusilobae, Radix Lespedezae Tomentosae, Radix Schefflerae Delavayi, Radix abutili indici, Folium Mahoniae, flower of Radix Notoginseng, Radix Silenes Tenuis, Herba Maianthemi Bifolii, Herba avenae fatuae, Herba leonuri pseudoma cranthi, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Caulis Spatholobi, Galium spurium L. is the medicine heat-clearing and toxic substances removing suppressing the hyperactive liver fire of the monarch and his subjects, cooling blood and removing stasis relaxing muscles and tendons network, with Oletum Trogopterori, Herba Trifolii Pepentis, Flos Sophorae, Radix Rosae Cymosae, Mylabris, Radix Ophiopogonis Dracaenoidis, Radix Arnebiae (Radix Lithospermi), Radix Achyranthis Bidentatae, Semen Cuscutae, Fructus Rubi, Radix Aconiti Lateralis Preparata, Flos Rhododendri Delavayi, Folium Nelumbinis, Plumula Nelumbinis, Fructus Vitis viniferae, Fructus Mori, Folium Ginseng, Fructus chebulae immaturus, Folium Ginkgo, Flos Lilii viriduli, Flos Albiziae, Flos Moutan, the medicine of Flos Ginseng for assisting a ruler in governing a country, kidney tonifying detoxifies, cooling blood and removing stasis, nourishing YIN and invigorating YANG, soothing the liver QI invigorating, all medicines share has significant curative effect for lupus erythematosus pathogenesis, supplement vitality of human body, enhancing immunity.By coordinating traditional western medical treatment, can antagonism inflammatory mediator and endotoxic release effectively, better improve patients symptomatic, alleviate or suppress systemic inflammatory response, protect each tract function, improving the effective percentage for the treatment of lupus erythematosus.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively:
On cough tree 20 weight portion ~ 30 weight portion, Flos Tagetis Erectae inflorescence 20 weight portion ~ 30 weight portion, Radix Bauhiniae pemervosae 20 weight portion ~ 30 weight portion, Radix Clematidis Argentilucidae 20 weight portion ~ 30 weight portion, Caulis et Folium (Gouaniae Leptostachyae) 20 weight portion ~ 30 weight portion, Cortex Linderae Obtusilobae 45 weight portion ~ 55 weight portion, Radix Lespedezae Tomentosae 45 weight portion ~ 55 weight portion, Radix Schefflerae Delavayi 45 weight portion ~ 55 weight portion, Radix abutili indici 45 weight portion ~ 55 weight portion, Folium Mahoniae 55 weight portion ~ 65 weight portion, flower of Radix Notoginseng 55 weight portion ~ 65 weight portion, Radix Silenes Tenuis 55 weight portion ~ 65 weight portion, Herba Maianthemi Bifolii 30 weight portion ~ 40 weight portion, Herba avenae fatuae 30 weight portion ~ 40 weight portion, Herba leonuri pseudoma cranthi 30 weight portion ~ 40 weight portion, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 30 weight portion ~ 40 weight portion, Caulis Spatholobi 30 weight portion ~ 40 weight portion, Galium spurium L. 30 weight portion ~ 40 weight portion, Oletum Trogopterori 10 weight portion ~ 20 weight portion, Herba Trifolii Pepentis 10 weight portion ~ 20 weight portion, Flos Sophorae 10 weight portion ~ 20 weight portion, Radix Rosae Cymosae 10 weight portion ~ 20 weight portion, Mylabris 10 weight portion ~ 20 weight portion, Radix Ophiopogonis Dracaenoidis 10 weight portion ~ 20 weight portion, Radix Arnebiae (Radix Lithospermi) 10 weight portion ~ 20 weight portion, Radix Achyranthis Bidentatae 10 weight portion ~ 20 weight portion, Semen Cuscutae 10 weight portion ~ 20 weight portion, Fructus Rubi 10 weight portion ~ 20 weight portion, Radix Aconiti Lateralis Preparata 10 weight portion ~ 20 weight portion, Flos Rhododendri Delavayi 10 weight portion ~ 20 weight portion, Folium Nelumbinis 10 weight portion ~ 20 weight portion, Plumula Nelumbinis 10 weight portion ~ 20 weight portion, Fructus Vitis viniferae 10 weight portion ~ 20 weight portion, Fructus Mori 10 weight portion ~ 20 weight portion, Folium Ginseng 10 weight portion ~ 20 weight portion, Fructus chebulae immaturus 10 weight portion ~ 20 weight portion, Folium Ginkgo 10 weight portion ~ 20 weight portion, Flos Lilii viriduli 10 weight portion ~ 20 weight portion, Flos Albiziae 10 weight portion ~ 20 weight portion, Flos Moutan 10 weight portion ~ 20 weight portion, Flos Ginseng 10 weight portion ~ 20 weight portion.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively:
On cough tree 23 weight portion ~ 27 weight portion, Flos Tagetis Erectae inflorescence 23 weight portion ~ 27 weight portion, Radix Bauhiniae pemervosae 23 weight portion ~ 27 weight portion, Radix Clematidis Argentilucidae 23 weight portion ~ 27 weight portion, Caulis et Folium (Gouaniae Leptostachyae) 23 weight portion ~ 27 weight portion, Cortex Linderae Obtusilobae 46 weight portion ~ 52 weight portion, Radix Lespedezae Tomentosae 46 weight portion ~ 52 weight portion, Radix Schefflerae Delavayi 46 weight portion ~ 52 weight portion, Radix abutili indici 46 weight portion ~ 52 weight portion, Folium Mahoniae 58 weight portion ~ 63 weight portion, flower of Radix Notoginseng 58 weight portion ~ 63 weight portion, Radix Silenes Tenuis 58 weight portion ~ 63 weight portion, Herba Maianthemi Bifolii 32 weight portion ~ 38 weight portion, Herba avenae fatuae 32 weight portion ~ 38 weight portion, Herba leonuri pseudoma cranthi 32 weight portion ~ 38 weight portion, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 32 weight portion ~ 38 weight portion, Caulis Spatholobi 32 weight portion ~ 38 weight portion, Galium spurium L. 32 weight portion ~ 38 weight portion, Oletum Trogopterori 12 weight portion ~ 18 weight portion, Herba Trifolii Pepentis 12 weight portion ~ 18 weight portion, Flos Sophorae 12 weight portion ~ 18 weight portion, Radix Rosae Cymosae 12 weight portion ~ 18 weight portion, Mylabris 12 weight portion ~ 18 weight portion, Radix Ophiopogonis Dracaenoidis 12 weight portion ~ 18 weight portion, Radix Arnebiae (Radix Lithospermi) 12 weight portion ~ 18 weight portion, Radix Achyranthis Bidentatae 12 weight portion ~ 18 weight portion, Semen Cuscutae 12 weight portion ~ 18 weight portion, Fructus Rubi 12 weight portion ~ 18 weight portion, Radix Aconiti Lateralis Preparata 12 weight portion ~ 18 weight portion, Flos Rhododendri Delavayi 12 weight portion ~ 18 weight portion, Folium Nelumbinis 12 weight portion ~ 18 weight portion, Plumula Nelumbinis 12 weight portion ~ 18 weight portion, Fructus Vitis viniferae 12 weight portion ~ 18 weight portion, Fructus Mori 12 weight portion ~ 18 weight portion, Folium Ginseng 12 weight portion ~ 18 weight portion, Fructus chebulae immaturus 12 weight portion ~ 18 weight portion, Folium Ginkgo 12 weight portion ~ 18 weight portion, Flos Lilii viriduli 12 weight portion ~ 18 weight portion, Flos Albiziae 12 weight portion ~ 18 weight portion, Flos Moutan 12 weight portion ~ 18 weight portion, Flos Ginseng 12 weight portion ~ 18 weight portion.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively:
On cough tree 25 weight portion, Flos Tagetis Erectae inflorescence 25 weight portion, Radix Bauhiniae pemervosae 25 weight portion, Radix Clematidis Argentilucidae 25 weight portion, Caulis et Folium (Gouaniae Leptostachyae) 25 weight portion, Cortex Linderae Obtusilobae 50 weight portion, Radix Lespedezae Tomentosae 50 weight portion, Radix Schefflerae Delavayi 50 weight portion, Radix abutili indici 50 weight portion, Folium Mahoniae 60 weight portion, flower of Radix Notoginseng 60 weight portion, Radix Silenes Tenuis 60 weight portion, Herba Maianthemi Bifolii 35 weight portion, Herba avenae fatuae 35 weight portion, Herba leonuri pseudoma cranthi 35 weight portion, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 35 weight portion, Caulis Spatholobi 35 weight portion, Galium spurium L. 35 weight portion, Oletum Trogopterori 15 weight portion, Herba Trifolii Pepentis 15 weight portion, Flos Sophorae 15 weight portion, Radix Rosae Cymosae 15 weight portion, Mylabris 15 weight portion, Radix Ophiopogonis Dracaenoidis 15 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Radix Achyranthis Bidentatae 15 weight portion, Semen Cuscutae 15 weight portion, Fructus Rubi 15 weight portion, Radix Aconiti Lateralis Preparata 15 weight portion, Flos Rhododendri Delavayi 15 weight portion, Folium Nelumbinis 15 weight portion, Plumula Nelumbinis 15 weight portion, Fructus Vitis viniferae 15 weight portion, Fructus Mori 15 weight portion, Folium Ginseng 15 weight portion, Fructus chebulae immaturus 15 weight portion, Folium Ginkgo 15 weight portion, Flos Lilii viriduli 15 weight portion, Flos Albiziae 15 weight portion, Flos Moutan 15 weight portion, Flos Ginseng 15 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is soup potus, be specially:
Each component is dried pulverizing respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, decoct 2 ~ 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boils rear slow fire, and second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup potus.
Present invention also offers the application of above-mentioned Chinese medicine composition in the medicine for the preparation for the treatment of lupus erythematosus.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention is by coordinating traditional western medical treatment; can antagonism inflammatory mediator and endotoxic release effectively; better improve patients symptomatic, alleviate or suppress systemic inflammatory response, protect each tract function, improving the effective percentage for the treatment of lupus erythematosus.
Detailed description of the invention
The pharmacology of each crude drug is as follows:
Herba Lepidogrammitis rostratae:
[nature and flavor] micro-hardship; Sweet; Flat
[return through] lung; Small intestine meridian
[function cures mainly] clearing away heat and promoting diuresis; Cough-relieving; Relieving restlessness; Removing toxic substances and promoting subsidence of swelling.Main uroschesis; Drench the puckery pain of drop; Heat syndrome cough; Vexed; Skin infection swells and ache; Traumatic injury.
Flos Tagetis Erectae inflorescence: bitter, cool.Suppressing the hyperactive liver is antipyretic, dispelling pathogenic wind and eliminating phlegm.For having a dizzy spell, wind syndrome of head ophthalmalgia, infantile convulsion, cold cough, pertussis, mastalgia, mumps.
Radix Bauhiniae pemervosae:
[nature and flavor] are pungent, sour; Bitter; Temperature
[return through] heart; Lung; Kidney channel
[function cures mainly] stops blooding, antitussive, invigorating kidney for consolidating semen.Main metrorrhagia, cough, seminal emission, spermatorrhea, the enuresis
Radix Clematidis Argentilucidae:
[nature and flavor] acrid in the mouth, warm in nature.
[function cures mainly-Radix Clematidis Argentilucidae effect] promoting flow of QI and blood, wind-damp dispelling, pain relieving.
Caulis et Folium (Gouaniae Leptostachyae):
[meridian distribution of property and flavor] is sour, puckery, cool.
[function cures mainly] removing pathogenic heat from blood and toxic substance from the body, relaxing muscles and tendons and activating QI and blood in the collateral.For numb limbs and tense tendons; Burn and scald is controlled in external, skin infection.
Cortex Linderae Obtusilobae:
Cortex Linderae Obtusilobae is the bark of canella Cortex Linderae Obtusilobae, invigorate blood circulation, relaxing muscles and tendons, dissipating blood stasis, the effect such as detumescence.
[nature and flavor] " Shaanxi Chinese herbal medicine ": " acrid in the mouth, warm in nature."
[function cures mainly] " Shaanxi Chinese herbal medicine ": " relaxing muscles and tendons to promote blood circulation, dissipating blood stasis for subsidence of swelling.Control traumatic injury, swelling and pain due to blood stasis."
Flower of Radix Notoginseng:
[nature and flavor] are cool in nature, sweet in the mouth, micro-hardship.
[function] is mainly used in that heat clearing away, removing toxic substances, removing heat from blood, blood pressure lowering, tune fat, immunomodulating, blood circulation and channel invigorating, health preserving are anti-ageing, the active ingredient of anti-inflammatory analgesic action.There is significant suppressing the hyperactive liver, eliminate the phlegm, relieving asthma, sleeping, effect such as coronary dilating, antiallergic, eliminating toxin and beautifying the skin of easing pain.
Radix Schefflerae Delavayi:
[nature and flavor] mildly bitter flavor; Puckery; Property is put down
[function cures mainly] dispelling, collateral-activating; Strengthening the tendons and bones; Promoting flow of QI and blood.Main air
Pain of dampness syndrome; Soreness of waist and knee joint; Treating swelling and pain by traumatic injury; Breast side of body abdominal distention
2. Guizhou folk medicine ": " logical stool, detumescence poison.”
2. " the practical Chinese herbal medicine in Guangxi newly selects ": " dispelling, collateral-activating.Control fracture, dampen, rheumatic arthritis, lumbar muscle strain.”
Herba Maianthemi Bifolii:
[medical value] cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main haematemesis; Hematuria; Menorrhagia; Traumatic hemorrhage; Sore, carbuncle and painful swelling.
Radix Ophiopogonis Dracaenoidis:
[nature and flavor] property is put down, sweet in the mouth.
[function cures mainly] centering is calmed the nerves, and relieving cough and resolving phlegm, controls cardiopalmus, rheumatic heart disease, pulmonary tuberculosis, chronic tracheitis, bronchitis.
Folium Ginseng:
[meridian distribution of property and flavor] is bitter, sweet, cold.Attach to the lung and stomach meridians.
[function cures mainly] QI invigorating, lung benefiting, drives away summer heat, and promotes the production of body fluid.For qi-asthenia cough, summer-heat is irritated, and Tianjin wound is thirsty, and the head is unclear, and extremity are tired weary.
Radix Lespedezae Tomentosae:
[nature and flavor] are sweet; Micro-light; Property is put down
[return through] spleen channel
[function cures mainly] spleen invigorating tonify deficiency; Clearing away heat-damp and promoting diuresis; Promoting blood flow to regulate menstruation.Main asthenia; Blood deficiency is dizzy; Edema; Ascites; Dysentery; Amenorrhea; Dysmenorrhea
Radix abutili indici:
[meridian distribution of property and flavor] sweet in the mouth, light, property is put down.
" Guangxi Chinese medicinal herbal ": " sweet in the mouth, property is put down, nontoxic.Enter spleen, lung, urinary bladder channel.”[2]
[effect] clearing away heat-damp and promoting diuresis; Sensiblely to invigorate blood circulation.Cure mainly xeropulmonary cough; Stomachache; Stomachache; Have loose bowels; Stranguria; Hernia; Traumatic injury; Hiccough and deaf.
Folium Mahoniae:
[meridian distribution of property and flavor]: bitter, cold; " decoction pieces is newly joined ": " bitter, cool." enter liver, stomach, large intestine three warp; " book on Chinese herbal medicine is new again ": " enter lung meridian.”
[effect]: heat clearing away tonify deficiency, relieving cough and resolving phlegm.
[curing mainly]: control pulmonary tuberculosis hemoptysis, osteopyrexia and fever, dizziness and tinnitus, waist soreness, vexed, conjunctival congestion.
Radix Silenes Tenuis:
Nature and flavor: bitter; Property flat returns through liver; Urinary bladder channel
Function cures mainly: clearing away heat-damp and promoting diuresis; Promoting blood flow to regulate menstruation; Hemostasis.Main pyretic stranguria; Stranguria with blood; Dysuria; Dysentery; Menoxenia; Amenorrhea; Metrorrhagia; Traumatic hemorrhage.
Herba avenae fatuae:
Effect: hidroschesis; Hasten parturition
Nature and flavor with return through: sweet, flat.
Function with cure mainly: astringing to arrest bleeding, strengthening superficial resistance to stop perspiration.For spitting blood, metrorrhagia, leucorrhea, has blood in stool, spontaneous perspiration, night sweat.
Herba leonuri pseudoma cranthi:
[nature and flavor] taste abnormal pigmentary deposit on the skin; Property is put down
[function cures mainly] promoting blood flow to regulate menstruation; Removing toxic substances and promoting subsidence of swelling.Main menoxenia; Amenorrhea; Dysmenorrhea; Postnatal blood stasis is suffered from abdominal pain; Metrorrhagia; Traumatic pain; Carbuncle sore.
Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati):
Effect: dissipating blood stasis stops blooding, and regulating menstruation, blood pressure lowering, liver heat removing, invigorates blood circulation, pain relieving.For hypertension, menoxenia, injured bone, skin infection.Root, stem: hemoptysis of pulmonary tuberculosis, stomachache, rheumatic arthritis, traumatic injury.
Caulis Spatholobi:
[meridian distribution of property and flavor] is bitter, sweet, temperature.Return liver, kidney channel.
[function cures mainly] enriches blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Oletum Trogopterori:
[nature and flavor] are sweet, temperature.
[function cures mainly] promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.It is logical that Oletum Trogopterori hardship lets out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly.”
Galium spurium L.:
Bitter in the mouth is cold in nature, is apt to away blood system, can cooling blood for hemostasis, promoting the circulation of blood of invigorating blood circulation again, thus can be used for bleeding due to blood-heat or blood stasis venation go out blood disorder, for the heat in blood folder stasis of blood various go out blood disorder, particularly suitable.Energy the meridian dredging, clots absorbing is stagnant, thus the available card controlling the blood stasis meridians impatencies such as amenorrhea, traumatic injury, rheumatic arthralgia, particularly Fuke Tiaojing key medicine.
Herba Trifolii Pepentis:
[nature and flavor] property is put down, and taste is micro-sweet.
[function cures mainly] heat clearing away; Removing heat from blood; Mind calming.Main insane disease; Bleeding hemorrhoids; Node is fast.
Flos Sophorae: nature and flavor with return through: bitter in the mouth, be slightly cold.Return liver, large intestine channel.Function with cure mainly: cooling blood for hemostasis, blood pressure lowering.For spitting blood, have blood in stool, bleeding hemorrhoids, hematuria metrorrhagia, hypertension.Suitable amount used externally.Many parch to black that stops blooding are used; The many raw use of expelling phlegm for arresting cough.
Radix Rosae Cymosae: bitter is flat.1. " the SHENGCAO property of medicine is standby to be wanted ": " warm in nature." 2. " Chongqing medical herbs ": " bitter in the mouth, property is put down, nontoxic." enter the heart, liver, lung three warp.Function cures mainly: dissipating blood stasis, hemostasis, subduing swelling and detoxicating.Control menoxenia, uterine prolapse, hemorrhoid, proctoptosis, sore, traumatic hemorrhage.
Mylabris:
[nature and flavor, return through] are pungent, heat; Very toxic.Return liver, stomach, kidney channel.
[function cures mainly] removing blood stasis Xiao wei, merit poison phagedenoma, draws red foaming.Yong Yu WEIJIA lump, stubborn dermatitis for many years, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil.
Radix Arnebiae (Radix Lithospermi): nature and flavor: cold in nature is sweet in the mouth, salty.Gui Jing: GUIXIN, Liver Channel.Function cures mainly removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Radix Achyranthis Bidentatae:
[meridian distribution of property and flavor] bitter in the mouth, acid, flat; Return liver, kidney channel.
[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Semen Cuscutae:
[nature and flavor] Gan Xinping, enters liver, kidney channel.
[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.For caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, the diseases such as frequent fetal movement.
Fructus Rubi:
[nature and flavor] temperature; Sweet, sour; Return kidney, urinary bladder channel.
[function cures mainly] kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.
Radix Aconiti Lateralis Preparata:
[nature and flavor] are pungent, sweet, hot greatly; Poisonous; GUIXIN, kidney, spleen channel.
[function]
recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain." for recuperating depleted YANG and rescuing the patient from collapse first product medicine "
[curing mainly] for excessive YIN keeping YANG externally, profuse sweating
yANG-depletion, vomiting and diarrhoea, it is inverse to faint, cold extremities faint pulse,
trusted subordinatecold type of pain, cold-dysentery, beriberi
edema, anemofrigid-damp arthralgia, sexual impotence, cold womb,
deficiency and coldnessvomit and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.
Flos Rhododendri Delavayi:
[nature and flavor] nature and flavor are bitter, cool, slightly poisonous.
[function cures mainly] heat clearing away is drawn out pus by applying a plaster to the affected part,
hemostasis,
regulating menstruation.Cure mainly
osteomyelitis,
digestive tracthemorrhage,
spitting of blood,
epistaxis,
menoxenia.
Folium Nelumbinis:
[nature and flavor] are pained, flat.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature is put down, acrid in the mouth." 2. " book on Chinese herbal medicine is high former ": " abnormal smells from the patient is bitter, flat, nontoxic." 3. " medical center bun is wanted ": " is pained, flat, micro-salty." enter the heart, liver, spleen channel.1. " book on Chinese herbal medicine is looked for the truth ": " enter gallbladder." 2. " book on Chinese herbal medicine is new again ": " enters the heart, liver, lung three warp." 3. " book on Chinese herbal medicine brief points ": " enters lunar, the Yangming Channel of foot."
[function cures mainly] clearing away summer-heat, sending up the lucid YANG,
cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen,
heat in bloodtell nosebleed, metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.For multiple hemorrhage and puerperal blood faints.
Plumula Nelumbinis:
[nature and flavor] are bitter, cold, nontoxic;
[effect] clears away heart-fire, and reduces phlegm and internal heat, hemostasis, arresting seminal emission.Control vexed, thirsty, spit blood, seminal emission, conjunctival congestion and swelling pain." book on Chinese herbal medicine is new again ": clearing away heart-fire, suppressing the hyperactive liver fire, lung-fire, falls in purgation of spleen excess fire.Relieve summer heat relieving restlessness, promoting the production of body fluid to quench thirst, controls order redness.
Flos Lilii viriduli:
[nature and flavor] Bulbus Lilii sweet in the mouth, cold nature; GUIXIN, lung meridian.
[function cures mainly] nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Have nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN, sputum mixed with blood, as all sorts of flowers cream.Control chronic cough of deficiency lung, chronic cough is spat blood, as baihe gujin decoction.Have clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep etc.
Flos Albiziae:
There is calming effects, mainly control the effects such as pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.Shu Yu, regulates the flow of vital energy, and calms the nerves, active.Control pent-up uncomfortable in chest, insomnia, forgetful, wind-fire ophthalmic, blurring of vision, pharyngalgia, carbuncle, traumatic injury pain.
Flos Moutan:
Paeonia suffruticosa not only has ornamental value, but also has very high medical value.Being processed into " Cortex Moutan " by the root of Paeonia suffruticosa, is famous and precious
chinese herbal medicine.Its cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warp, have dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition,
antibacterialeffect of antiinflammatory, clothes can beneficial body for a long time
lengthen the life.Nourish blood regulating liver-QI, loose strongly fragrant blood stasis dispelling, is applicable to face
chloasma, skin aging, normal drink QI and blood lung alive, appearance is ruddy, improves menoxenia,
dysmenorrhea, only sweating due to debility,
night sweat.
Flos Ginseng:
[nature and flavor]: bitterness Hui Tian, have the pungent sweet taste of Radix Ginseng.
[function]: supplement vitality of human body, regain one's strength, strengthens body immunity.
Fructus Vitis viniferae:
The micro-acid of [nature and flavor] sweet in the mouth, property are put down,
[function] has invigorating the liver and kidney, replenishing QI and blood, appetizing are promoted the production of body fluid, effect of diuresis.Modern medicine study shows, Fructus Vitis viniferae also has anti-cancer, anticancer effect.
Fructus Mori:
[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.
[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary curative effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.
Folium Ginseng:
[meridian distribution of property and flavor] is bitter, sweet, cold.Attach to the lung and stomach meridians.
[function cures mainly] QI invigorating, lung benefiting, drives away summer heat, and promotes the production of body fluid.For qi-asthenia cough, summer-heat is irritated, and Tianjin wound is thirsty, and the head is unclear, and extremity are tired weary.
Fructus chebulae immaturus:
[meridian distribution of property and flavor] is bitter, sour, puckery, flat.Return lung, large intestine channel.
[function cures mainly] clearing away heat and promoting production of body fluid, removing toxic substances.Deficiency of YIN diphtheria.
Folium Ginkgo:
[meridian distribution of property and flavor] bitter in the mouth, puckery, flat; The benefit heart is astringed the lung, removing dampness antidiarrheal.
[function cures mainly] is uncomfortable in chest pained, severe palpitation, and phlegm dyspnea is coughed, dysentery, leucorrhea.
The concrete preparation of embodiment 1 injection 1
By on cough tree 20mg, Flos Tagetis Erectae inflorescence 20 mg, Radix Bauhiniae pemervosae 20 mg, Radix Clematidis Argentilucidae 20 mg, Caulis et Folium (Gouaniae Leptostachyae) 20 mg, Cortex Linderae Obtusilobae 45 mg, Radix Lespedezae Tomentosae 45 mg, Radix Schefflerae Delavayi 45 mg, Radix abutili indici 45 mg, Folium Mahoniae 55 mg, flower of Radix Notoginseng 55 mg, Radix Silenes Tenuis 55 mg, Herba Maianthemi Bifolii 30 mg, Herba avenae fatuae 30 mg, Herba leonuri pseudoma cranthi 30 mg, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 30 mg, Caulis Spatholobi 30 mg, Galium spurium L. 30 mg, Oletum Trogopterori 10 mg, Herba Trifolii Pepentis 10 mg, Flos Sophorae 10 mg, Radix Rosae Cymosae 10 mg, Mylabris 10 mg, Radix Ophiopogonis Dracaenoidis 10 mg, Radix Arnebiae (Radix Lithospermi) 10 mg, Radix Achyranthis Bidentatae 10 mg, Semen Cuscutae 10 mg, Fructus Rubi 10 mg, Radix Aconiti Lateralis Preparata 10 mg, Flos Rhododendri Delavayi 10 mg, Folium Nelumbinis 10 mg, Plumula Nelumbinis 10 mg, Fructus Vitis viniferae 10 mg, Fructus Mori 10 mg, Folium Ginseng 10 mg, Fructus chebulae immaturus 10 mg, Folium Ginkgo 10 mg, Flos Lilii viriduli 10 mg, Flos Albiziae 10 mg, Flos Moutan 10 mg, Flos Ginseng 10 mg dries rear pulverizing respectively, mixing, obtains mixture, add water to and flood mixture powder 5cm, soak 2 hours, heating decocts, boil rear slow fire, decoct 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 5cm, heated and boiled, boil rear slow fire, second time decocts 2 hours after boiling, and filters, merges the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, get 500ml filtrate, inject water to 1000ml, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtained injection 1.
Embodiment 2 toxicological experiment
Choose KM mice 60, be divided into treatment group and matched group at random according to body weight, often organize 30, male and female half and half, before administration, fasting can't help water 12 hours, and treatment group mice of the present invention is according to the administration capacity intravenously administrable of 0.25ml/10g; Matched group gavage water.At once the reaction of animal is observed after administration, comprise the form of animal, behavioral activity, the mental status, appetite, defecation and color thereof, fur, nose, eye, mouth with or without abnormal secretion thing and animal dead situation, the dead timely postmortem of animal, if there is macroscopic pathological changes, carries out histopathologic examination.Administration is observed once for the 1st day every 1 hour, and later every day observes once, Continuous Observation 7 days, the reaction of record animal toxicity and death condition.Weigh mice before the test, the body weight of the 3rd day and the 7th day after test.From the response situation overall merit result of the test of body weight and animal, obtain the maximum tolerated dose of injection of the present invention to mice single dose intravenous and gastric infusion.If occur dead, then carry out acute median lethal dose(LD 50) (LD
50) mensuration, through experiment, KM mice single dose intravenous gives tested injection 17.075g crude drug/kg of the present invention, be equivalent to 187.5 times of the clinical maximum consumption per day of people, the righting reflex loss of animal at once after administration, palpitating speed, in 3min, righting reflex recovers, heartbeating recovery is normal, animal performance without exception, there is not any exception in whole duration of test, body weight increases with the prolongation of test period, with concurrent control group zero difference (p > 0.05), duration of test has no animal dead.Put to death mice at the end of observation period, postmortem is without macroscopic change, and therefore, the quantity of this medicine of this test prompting is a quite safe dosage.
The concrete preparation of embodiment 3 injection 2
By on cough tree 23mg, Flos Tagetis Erectae inflorescence 23 mg, Radix Bauhiniae pemervosae 23 mg, Radix Clematidis Argentilucidae 23 mg, Caulis et Folium (Gouaniae Leptostachyae) 23 mg, Cortex Linderae Obtusilobae 46 mg, Radix Lespedezae Tomentosae 46 mg, Radix Schefflerae Delavayi 46 mg, Radix abutili indici 46 mg, Folium Mahoniae 58 mg, flower of Radix Notoginseng 58 mg, Radix Silenes Tenuis 58 mg, Herba Maianthemi Bifolii 32 mg, Herba avenae fatuae 32 mg, Herba leonuri pseudoma cranthi 32 mg, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 32 mg, Caulis Spatholobi 32 mg, Galium spurium L. 32 mg, Oletum Trogopterori 12 mg, Herba Trifolii Pepentis 12 mg, Flos Sophorae 12 mg, Radix Rosae Cymosae 12 mg, Mylabris 12 mg, Radix Ophiopogonis Dracaenoidis 12 mg, Radix Arnebiae (Radix Lithospermi) 12 mg, Radix Achyranthis Bidentatae 12 mg, Semen Cuscutae 12 mg, Fructus Rubi 12 mg, Radix Aconiti Lateralis Preparata 12 mg, Flos Rhododendri Delavayi 12 mg, Folium Nelumbinis 12 mg, Plumula Nelumbinis 12 mg, Fructus Vitis viniferae 12 mg, Fructus Mori 12 mg, Folium Ginseng 12 mg, Fructus chebulae immaturus 12 mg, Folium Ginkgo 12 mg, Flos Lilii viriduli 12 mg, Flos Albiziae 12 mg, Flos Moutan 12 mg, Flos Ginseng 12 mg pulverizes respectively, mixing, obtains mixture, add water to and flood mixture powder 4cm, soak 2 hours, heating decocts, boil rear slow fire, decoct 3 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 4cm, heated and boiled, boil rear slow fire, second time decocts 2 hours after boiling, and filters, merges the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, get 500ml filtrate, inject water to 1000ml, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtained injection 2.
The concrete preparation of embodiment 4 injection 3
By on cough tree 25mg, Flos Tagetis Erectae inflorescence 25mg, Radix Bauhiniae pemervosae 25mg, Radix Clematidis Argentilucidae 25mg, Caulis et Folium (Gouaniae Leptostachyae) 25mg, Cortex Linderae Obtusilobae 50mg, Radix Lespedezae Tomentosae 50mg, Radix Schefflerae Delavayi 50mg, Radix abutili indici 50mg, Folium Mahoniae 60mg, flower of Radix Notoginseng 60mg, Radix Silenes Tenuis 60mg, Herba Maianthemi Bifolii 35mg, Herba avenae fatuae 35mg, Herba leonuri pseudoma cranthi 35mg, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 35mg, Caulis Spatholobi 35mg, Galium spurium L. 35mg, Oletum Trogopterori 15mg, Herba Trifolii Pepentis 15mg, Flos Sophorae 15mg, Radix Rosae Cymosae 15mg, Mylabris 15mg, Radix Ophiopogonis Dracaenoidis 15mg, Radix Arnebiae (Radix Lithospermi) 15mg, Radix Achyranthis Bidentatae 15mg, Semen Cuscutae 15mg, Fructus Rubi 15mg, Radix Aconiti Lateralis Preparata 15mg, Flos Rhododendri Delavayi 15mg, Folium Nelumbinis 15mg, Plumula Nelumbinis 15mg, Fructus Vitis viniferae 15mg, Fructus Mori 15mg, Folium Ginseng 15mg, Fructus chebulae immaturus 15mg, Folium Ginkgo 15mg, Flos Lilii viriduli 15mg, Flos Albiziae 15mg, Flos Moutan 15mg, Flos Ginseng 15mg pulverizes respectively, mixing, obtains mixture, add water to and flood mixture powder 5cm, soak 2 hours, heating decocts, boil rear slow fire, decoct 3 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 5cm, heated and boiled, boil rear slow fire, second time decocts 2 hours after boiling, and filters, merges the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, get 500ml filtrate, inject water to 1000ml, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtained injection 3.
The concrete preparation of embodiment 5 soup potus
By on cough tree 30mg, Flos Tagetis Erectae inflorescence 30mg, Radix Bauhiniae pemervosae 30mg, Radix Clematidis Argentilucidae 30mg, Caulis et Folium (Gouaniae Leptostachyae) 30mg, Cortex Linderae Obtusilobae 55mg, Radix Lespedezae Tomentosae 55mg, Radix Schefflerae Delavayi 55mg, Radix abutili indici 55mg, Folium Mahoniae 65mg, flower of Radix Notoginseng 65mg, Radix Silenes Tenuis 65mg, Herba Maianthemi Bifolii 40mg, Herba avenae fatuae 40mg, Herba leonuri pseudoma cranthi 40mg, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 40mg, Caulis Spatholobi 40mg, Galium spurium L. 40mg, Oletum Trogopterori 20mg, Herba Trifolii Pepentis 20mg, Flos Sophorae 20mg, Radix Rosae Cymosae 20mg, Mylabris 20mg, Radix Ophiopogonis Dracaenoidis 20mg, Radix Arnebiae (Radix Lithospermi) 20mg, Radix Achyranthis Bidentatae 20mg, Semen Cuscutae 20mg, Fructus Rubi 20mg, Radix Aconiti Lateralis Preparata 20mg, Flos Rhododendri Delavayi 20mg, Folium Nelumbinis 20mg, Plumula Nelumbinis 20mg, Fructus Vitis viniferae 20mg, Fructus Mori 20mg, Folium Ginseng 20mg, Fructus chebulae immaturus 20mg, Folium Ginkgo 20mg, Flos Lilii viriduli 20mg, Flos Albiziae 20mg, Flos Moutan 20mg, Flos Ginseng 20mg pulverizes respectively, mixing, obtains mixture, adds water to and flood mixture powder 5cm, soak 2 hours, heating decocts, and boils rear slow fire, first time decocts 4 hours after boiling, and leaches medicinal liquid, again adds water to and flood mixture powder 5cm in filtering residue, heated and boiled, boils rear slow fire, and second time decocts 2 hours after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 1 hour, extract supernatant, being concentrated into crude drug concentration is 2g/ml, obtains soup potus.
Embodiment 6 clinical data
Patient's physical data
Patient all accepts lupus erythematosus (not accompanying shock) patient for medical treatment from the court's in December ,-2014 emergency treatment in May, 2010, totally 105 examples.All meet lupus erythematosus diagnosis standard.At random patient is divided into 2 groups: matched group and treatment group, treatment group 55 example, matched group 50 example, acquisition and recording patient physical data and state of an illness data after being admitted to hospital, adopts APACHE II standards of grading assess patient severity extent.Two groups of patient population data and APACHE II mark more equal no significant difference (P > 0. 05).
Diagnostic criteria
DLE is mainly according to erythra feature and dermal pathology inspection.The person of having ready conditions can do immunofluorescent band experiment to help to make a definite diagnosis.The diagnosis of SLE is mainly comprehensively determined according to medical history, clinical manifestation and lab testing three aspect.The general SLE diagnostic criteria adopting the revision of Americanism damp disease association's nineteen eighty-two at present.Patient to have in 11 standards 4 or more items, in succession or simultaneously occurs, can make a definite diagnosis.
Standards of Chinese Medical Syndrome Differentiation
Standards of Chinese Medical Syndrome Differentiation: pathological change is excessive noxious heat, broadcasts bright nutrient blood, and damage blood network, be then shown in heating, and glossopharyngeum is burst pain, skin erythema, tells, vomits, urine, feces blood.The bright deficiency of YIN of heat, blood stasis network is empty, exopathogen numbness network, then arthralgia.Deficiency of YIN QI consumed, the evil malicious numbness heart, then shortness of breath and palpitation, uncomfortable in chest or pain, purple lip.Yin deficiency and blood stasis, then low grade fever, erythema color is dim.Damage of kidney-YIN gauge head is swooned, alopecia.Deficiency of YIN affecting YANG, deficiency of spleen-YANG and kidneyYANG, then edema of lower limbs, spinal column is aching and limp.In addition, feelings will internal injury, depression of liver-QI, hematogenous blockage, in ecchymosis, knot surveys the pain over the hypochondriac region with doing lower piece.
Meet above lupus erythematosus diagnosis standard, Standards of Chinese Medical Syndrome Differentiation and signature Informed Consent Form person simultaneously and get rid of following factors for including this research case in.
Exclusion standard
(1) the tract disease such as the chronic heart, liver, lung, kidney, blood coagulation; (2) malignant tumor; (3) spiritedness history of disease person; (4) HIV-ab is positive; (5) age is less than 18 years old or is greater than 80 years old; (6) anemia of pregnant woman or women breast-feeding their children; (7) be reluctant participate in test or mismatch therapist.
Therapeutic Method
Matched group: 1. antimalarial 2. Thalidomide 3. general morbidity example can low-dose Oral hormone.Etc. lupus erythematosus regular western medicine treatment therapeutic scheme as a control group.
Treatment group: at the injection 1 of the basic upper vein instillation embodiment of the present invention 1 preparation for the treatment of of control group scheme, inject 2 every day, each 250ml, the totally 10 days course for the treatment of.
Observation index
Every day observes patient temperature, respiratory frequency, the change of heart rate and other sings and symptomses; To be admitted to hospital the same day and the 5th, 10 day, to check routine blood test, routine urinalysis, electrolyte, Liver and kidney function, electrocardiogram, plasma C RP and PCT.CPR adopts rate scattering Nephelometric Determination, normal value 0 ~ 8mg/L; PCT adopts fluoroimmunoassay to measure, normal value <0. 5ng/ml.Simultaneously can according to change of illness state need increase the above physico-chemical examination of check at any time.
Statistical method
With the analysis of SPSS11. 5 statistical software.Adopt two-sided test, inspection level α=0. 05, measurement data represents with mean ± standard deviation; Between group, ranked data compare employing Wilcoxon rank test, compare the variance analysis adopting repeated measure in group.
Efficacy assessment standard and result
Efficacy assessment standard
Recovery from illness: above all observation index full recoveries are normal; Effective: the state of an illness is clearly better, there is 1 not recover normal in observation index; Effective: sb.'s illness took a favorable turn but not obvious, there are 2 or more not recover normal in MAIN OUTCOME MEASURES; Invalid: the state of an illness has no and takes a turn for the better or increase the weight of, and observation index is without being clearly better or increasing the weight of.
Result
Two groups of general curative effects compare, and the results are shown in Table 1.
A table 1 liang group general curative effect compares [example (%)]
As can be seen from Table 1, adopt Chinese medicine injection of the present invention can improve overall treatment effect to lupus erythematosus, treatment group is compared with matched group, and P<0.05, has comparability.
Before and after two groups of treatments, the change of inflammatory reaction is compared, and the results are shown in Table 2.
The comparison of inflammatory activity before and after table 2 liang group treatment
As can be seen from Table 2, through leukocyte count (WBC) and neutrophilic granulocyte ratio (Neu) situation of change at pre-treatment and after treatment of the patient of injections treatment of the present invention, comparatively matched group is more obvious, P < 0. 05, CRP after 2 groups of treatments, PCT level is all lower than level before the treatment of this group, all there is significant difference, P < 0. 05, and after treatment, the CRP for the treatment of group, PCT level comparatively matched group has obvious reduction, P < 0. 05, can find out from here, Chinese medicine injection of the present invention can antagonism inflammatory mediator and endotoxic release effectively, better improve patients symptomatic, improve the effective percentage for the treatment of lupus erythematosus.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of lupus erythematosus, it is characterized in that: its crude drug comprises: above cough tree, Flos Tagetis Erectae inflorescence, Radix Bauhiniae pemervosae, Radix Clematidis Argentilucidae, Caulis et Folium (Gouaniae Leptostachyae), Cortex Linderae Obtusilobae, Radix Lespedezae Tomentosae, Radix Schefflerae Delavayi, Radix abutili indici, Folium Mahoniae, flower of Radix Notoginseng, Radix Silenes Tenuis, Herba Maianthemi Bifolii, Herba avenae fatuae, Herba leonuri pseudoma cranthi, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Caulis Spatholobi, Galium spurium L., Oletum Trogopterori, Herba Trifolii Pepentis, Flos Sophorae, Radix Rosae Cymosae, Mylabris, Radix Ophiopogonis Dracaenoidis, Radix Arnebiae (Radix Lithospermi), Radix Achyranthis Bidentatae, Semen Cuscutae, Fructus Rubi, Radix Aconiti Lateralis Preparata, Flos Rhododendri Delavayi, Folium Nelumbinis, Plumula Nelumbinis, Fructus Vitis viniferae, Fructus Mori, Folium Ginseng, Fructus chebulae immaturus, Folium Ginkgo, Flos Lilii viriduli, Flos Albiziae, Flos Moutan, Flos Ginseng.
2. a kind of Chinese medicine composition being used for the treatment of lupus erythematosus according to claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively:
On cough tree 20 weight portion ~ 30 weight portion, Flos Tagetis Erectae inflorescence 20 weight portion ~ 30 weight portion, Radix Bauhiniae pemervosae 20 weight portion ~ 30 weight portion, Radix Clematidis Argentilucidae 20 weight portion ~ 30 weight portion, Caulis et Folium (Gouaniae Leptostachyae) 20 weight portion ~ 30 weight portion, Cortex Linderae Obtusilobae 45 weight portion ~ 55 weight portion, Radix Lespedezae Tomentosae 45 weight portion ~ 55 weight portion, Radix Schefflerae Delavayi 45 weight portion ~ 55 weight portion, Radix abutili indici 45 weight portion ~ 55 weight portion, Folium Mahoniae 55 weight portion ~ 65 weight portion, flower of Radix Notoginseng 55 weight portion ~ 65 weight portion, Radix Silenes Tenuis 55 weight portion ~ 65 weight portion, Herba Maianthemi Bifolii 30 weight portion ~ 40 weight portion, Herba avenae fatuae 30 weight portion ~ 40 weight portion, Herba leonuri pseudoma cranthi 30 weight portion ~ 40 weight portion, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 30 weight portion ~ 40 weight portion, Caulis Spatholobi 30 weight portion ~ 40 weight portion, Galium spurium L. 30 weight portion ~ 40 weight portion, Oletum Trogopterori 10 weight portion ~ 20 weight portion, Herba Trifolii Pepentis 10 weight portion ~ 20 weight portion, Flos Sophorae 10 weight portion ~ 20 weight portion, Radix Rosae Cymosae 10 weight portion ~ 20 weight portion, Mylabris 10 weight portion ~ 20 weight portion, Radix Ophiopogonis Dracaenoidis 10 weight portion ~ 20 weight portion, Radix Arnebiae (Radix Lithospermi) 10 weight portion ~ 20 weight portion, Radix Achyranthis Bidentatae 10 weight portion ~ 20 weight portion, Semen Cuscutae 10 weight portion ~ 20 weight portion, Fructus Rubi 10 weight portion ~ 20 weight portion, Radix Aconiti Lateralis Preparata 10 weight portion ~ 20 weight portion, Flos Rhododendri Delavayi 10 weight portion ~ 20 weight portion, Folium Nelumbinis 10 weight portion ~ 20 weight portion, Plumula Nelumbinis 10 weight portion ~ 20 weight portion, Fructus Vitis viniferae 10 weight portion ~ 20 weight portion, Fructus Mori 10 weight portion ~ 20 weight portion, Folium Ginseng 10 weight portion ~ 20 weight portion, Fructus chebulae immaturus 10 weight portion ~ 20 weight portion, Folium Ginkgo 10 weight portion ~ 20 weight portion, Flos Lilii viriduli 10 weight portion ~ 20 weight portion, Flos Albiziae 10 weight portion ~ 20 weight portion, Flos Moutan 10 weight portion ~ 20 weight portion, Flos Ginseng 10 weight portion ~ 20 weight portion.
3. a kind of Chinese medicine composition being used for the treatment of lupus erythematosus according to claim 1 and 2, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively:
On cough tree 23 weight portion ~ 27 weight portion, Flos Tagetis Erectae inflorescence 23 weight portion ~ 27 weight portion, Radix Bauhiniae pemervosae 23 weight portion ~ 27 weight portion, Radix Clematidis Argentilucidae 23 weight portion ~ 27 weight portion, Caulis et Folium (Gouaniae Leptostachyae) 23 weight portion ~ 27 weight portion, Cortex Linderae Obtusilobae 46 weight portion ~ 52 weight portion, Radix Lespedezae Tomentosae 46 weight portion ~ 52 weight portion, Radix Schefflerae Delavayi 46 weight portion ~ 52 weight portion, Radix abutili indici 46 weight portion ~ 52 weight portion, Folium Mahoniae 58 weight portion ~ 63 weight portion, flower of Radix Notoginseng 58 weight portion ~ 63 weight portion, Radix Silenes Tenuis 58 weight portion ~ 63 weight portion, Herba Maianthemi Bifolii 32 weight portion ~ 38 weight portion, Herba avenae fatuae 32 weight portion ~ 38 weight portion, Herba leonuri pseudoma cranthi 32 weight portion ~ 38 weight portion, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 32 weight portion ~ 38 weight portion, Caulis Spatholobi 32 weight portion ~ 38 weight portion, Galium spurium L. 32 weight portion ~ 38 weight portion, Oletum Trogopterori 12 weight portion ~ 18 weight portion, Herba Trifolii Pepentis 12 weight portion ~ 18 weight portion, Flos Sophorae 12 weight portion ~ 18 weight portion, Radix Rosae Cymosae 12 weight portion ~ 18 weight portion, Mylabris 12 weight portion ~ 18 weight portion, Radix Ophiopogonis Dracaenoidis 12 weight portion ~ 18 weight portion, Radix Arnebiae (Radix Lithospermi) 12 weight portion ~ 18 weight portion, Radix Achyranthis Bidentatae 12 weight portion ~ 18 weight portion, Semen Cuscutae 12 weight portion ~ 18 weight portion, Fructus Rubi 12 weight portion ~ 18 weight portion, Radix Aconiti Lateralis Preparata 12 weight portion ~ 18 weight portion, Flos Rhododendri Delavayi 12 weight portion ~ 18 weight portion, Folium Nelumbinis 12 weight portion ~ 18 weight portion, Plumula Nelumbinis 12 weight portion ~ 18 weight portion, Fructus Vitis viniferae 12 weight portion ~ 18 weight portion, Fructus Mori 12 weight portion ~ 18 weight portion, Folium Ginseng 12 weight portion ~ 18 weight portion, Fructus chebulae immaturus 12 weight portion ~ 18 weight portion, Folium Ginkgo 12 weight portion ~ 18 weight portion, Flos Lilii viriduli 12 weight portion ~ 18 weight portion, Flos Albiziae 12 weight portion ~ 18 weight portion, Flos Moutan 12 weight portion ~ 18 weight portion, Flos Ginseng 12 weight portion ~ 18 weight portion.
4. a kind of Chinese medicine composition being used for the treatment of lupus erythematosus according to claims 1 to 3 any one, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively:
On cough tree 25 weight portion, Flos Tagetis Erectae inflorescence 25 weight portion, Radix Bauhiniae pemervosae 25 weight portion, Radix Clematidis Argentilucidae 25 weight portion, Caulis et Folium (Gouaniae Leptostachyae) 25 weight portion, Cortex Linderae Obtusilobae 50 weight portion, Radix Lespedezae Tomentosae 50 weight portion, Radix Schefflerae Delavayi 50 weight portion, Radix abutili indici 50 weight portion, Folium Mahoniae 60 weight portion, flower of Radix Notoginseng 60 weight portion, Radix Silenes Tenuis 60 weight portion, Herba Maianthemi Bifolii 35 weight portion, Herba avenae fatuae 35 weight portion, Herba leonuri pseudoma cranthi 35 weight portion, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 35 weight portion, Caulis Spatholobi 35 weight portion, Galium spurium L. 35 weight portion, Oletum Trogopterori 15 weight portion, Herba Trifolii Pepentis 15 weight portion, Flos Sophorae 15 weight portion, Radix Rosae Cymosae 15 weight portion, Mylabris 15 weight portion, Radix Ophiopogonis Dracaenoidis 15 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Radix Achyranthis Bidentatae 15 weight portion, Semen Cuscutae 15 weight portion, Fructus Rubi 15 weight portion, Radix Aconiti Lateralis Preparata 15 weight portion, Flos Rhododendri Delavayi 15 weight portion, Folium Nelumbinis 15 weight portion, Plumula Nelumbinis 15 weight portion, Fructus Vitis viniferae 15 weight portion, Fructus Mori 15 weight portion, Folium Ginseng 15 weight portion, Fructus chebulae immaturus 15 weight portion, Folium Ginkgo 15 weight portion, Flos Lilii viriduli 15 weight portion, Flos Albiziae 15 weight portion, Flos Moutan 15 weight portion, Flos Ginseng 15 weight portion.
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| CN105288473A (en) * | 2015-10-30 | 2016-02-03 | 江崇礼 | Traditional Chinese medicine composition for treating lupus erythematosus and application thereof |
| CN105395611A (en) * | 2015-12-10 | 2016-03-16 | 刘力旗 | A medicine for external application for treating viral and immunological diseases and a preparing method thereof |
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| CN104042895A (en) * | 2014-06-30 | 2014-09-17 | 崔新明 | Traditional Chinese medicine composition for treating systemic lupus erythematosus and use thereof |
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| CN105288473A (en) * | 2015-10-30 | 2016-02-03 | 江崇礼 | Traditional Chinese medicine composition for treating lupus erythematosus and application thereof |
| CN105395611A (en) * | 2015-12-10 | 2016-03-16 | 刘力旗 | A medicine for external application for treating viral and immunological diseases and a preparing method thereof |
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