CN106860656A - It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application - Google Patents
It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application Download PDFInfo
- Publication number
- CN106860656A CN106860656A CN201510919775.3A CN201510919775A CN106860656A CN 106860656 A CN106860656 A CN 106860656A CN 201510919775 A CN201510919775 A CN 201510919775A CN 106860656 A CN106860656 A CN 106860656A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- osteoporosis
- medicine composition
- stir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
Chinese medicine composition of osteoporosis and its preparation method and application is treated the invention discloses a kind of.Described Chinese medicine composition is to merge to extract by the bulk drug of following weight portion to be obtained：10~60 parts of 8~40 parts of barrenwort, 10~60 parts of the rhizome of davallia, 10~60 parts of the Radix Astragali, 10~60 parts of stir-baked SEMEN PSORALEAE with salt solution, 15~80 parts of prepared rhizome of rehmannia, 8~40 parts of Radix Angelicae Sinensis, 10~60 parts of stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron, specific preparation comprise the following steps：Each composition Chinese medicine is weighed by proportioning, is added water to decoct together and is extracted, merged and decoct extract solution, filtering, concentration, centrifugation is dried, and dry extract is obtained.Pharmacodynamics test shows：The Chinese medicine composition of the treatment osteoporosis that the present invention is provided, is remarkably improved the overall bone amount and calcium, phosphorus, the content of organic matter of osteoporosis rat lumbar vertebra, improves bone structure；Effect with good treatment osteoporosis, and without the obvious side effect of appearance, it is expected to the pharmaceutical preparation for preparing treatment osteoporosis, with prospect in medicine.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to it is a kind of treat Chinese medicine composition of osteoporosis and preparation method thereof and
Using.
Background technology
Osteoporosis (Osteoporosis, OP) is reduced with bone amount, and bone tissue microstructure degenerative change is characterized, and is caused
Increase bone fragility, easily a kind of general metabolism osteopathy of hair fracture.Its feature is that bone amount and bone matrix are in ratio in unit volume
Reduce, cortex of bone is thinning, and bone trabecula number and volume size are reduced, and pulp cavity broadens, and bone ore deposit composition is unbalance, cause the crisp of bone
Property increase, biomechanics of bone intensity declines, and load endurance is reduced, and the visible cortex of bone of pathological anatomy is thinning, the sparse atrophy of bone trabecula,
Bone bed is not thick, thus clinical manifestation to have a pain in the back, skeleton pain, deformity of spine, or even fracture.The disease is multiple to be born in absolutely
Women, the elderly and various chronics after, once it is difficult to effect a radical cure.With the increase of the aged, OP suffers from
Person is also continuously increased.According to statistics, the current whole world has more than 200,000,000 people with osteoporosis, and it is various that its incidence of disease has leapt to the world
The 7th of common disease, China's patients with osteoporosis is more than 100,000,000 people, it is contemplated that be up to 2.12 hundred million people to the year two thousand fifty.This is
One serious social concern, WHO is classified as one of three big diseases of old people, has been subjected to the height weight of national governments and medical matters circle
Depending on.
The disease is main based on drug therapy at present, clinical many using calcium preparation, sex hormone, diphosphonate, calcitonin, fluorination
Thing, activated vitamin D etc..But existed in western medicine adverse drug reaction, patient do not tolerate and some medicines treatment
The problems such as imitating imprecise, its application is subject to a definite limitation.And ten several or even tens kinds of biologies can be contained in compound Chinese medicinal preparation
Active component, the effect of performance treatment osteoporosis, including stimulate the synthesis of extracellular matrix components, promote osteoblast adhesion
Propagation, increases the balance of bone density, promoting bone growing and trace element；Estrogen-like effect is played, is increased osteocytic and is swashed
The sensitiveness of plain acceptor；Suppress bone conversion, reduce the many-sides such as bone information.The traditional Chinese medicine of China is for anti-curing osteoporosis side
There is rich experience in face, but is not widely used at present.What Chinese medicine compound prescription was developed in osteoporosis is treated
Depth, range aspect need further raising.
The content of the invention
In view of the above-mentioned problems existing in the prior art, it is an object of the invention to provide one kind can effectively, low toxicity treatment osteoporosis
Chinese medicine composition and its preparation method and application.
For achieving the above object, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine composition for treating osteoporosis, merges extraction and is prepared from by the bulk drug of following masses part：Barrenwort
8~40 parts, 10~60 parts of the rhizome of davallia, 10~60 parts of the Radix Astragali, 10~60 parts of stir-baked SEMEN PSORALEAE with salt solution, 15~80 parts of prepared rhizome of rehmannia, Radix Angelicae Sinensis 8~40
10~60 parts of part, 10~60 parts of stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron.
Used as a kind of preferred scheme, the Chinese medicine composition of described treatment osteoporosis is merged by the bulk drug of following masses part
Extraction is prepared from：It is 10~25 parts of barrenwort, 20~40 parts of the rhizome of davallia, 20~40 parts of the Radix Astragali, 20~40 parts of stir-baked SEMEN PSORALEAE with salt solution, ripe
20~40 parts of 20~60 parts of glutinous rehmannia, 10~25 parts of Radix Angelicae Sinensis, 20~40 parts of stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron.
Used as further preferred scheme, the Chinese medicine composition of described treatment osteoporosis, is by the bulk drug of following masses part
Merge extraction to be prepared from：10 parts of barrenwort, 15 parts of the rhizome of davallia, 15 parts of the Radix Astragali, 15 parts of stir-baked SEMEN PSORALEAE with salt solution, prepared rhizome of rehmannia 20
Part, 10 parts of Radix Angelicae Sinensis, 15 parts of stir-baked CORTEX EUCOMMIAE with salt solution and 15 parts of vinegar tortoise plastron.
A kind of preparation method of the Chinese medicine composition of described treatment osteoporosis, comprises the following steps：Each group is weighed by proportioning
Into Chinese medicine, add water to decoct together and extract, merge and decoct extract solution, filtering, concentration, centrifugation is dried, and dry extract is obtained.
Used as a kind of preferred scheme, when adding water to cook extraction, the volume that adds water every time is 8~15 times of medicinal material gross mass, is decocted every time
Boil 0.5~2 hour, decoct extract 1~3 time altogether.
Used as a kind of preferred scheme, it is 1.0~2.0 to be concentrated into the relative density at 20 DEG C.
Used as a kind of preferred scheme, described centrifugation is centrifuged 10~30 minutes under the rotating speed of 5000~8000r/min.
Used as a kind of preferred scheme, described drying is spray drying or vacuum drying, and drying temperature is 60~80 DEG C.
Further, the optimum extraction condition：The volume that adds water is 12 times of medicinal material gross mass, extraction time 3 times, every time
1 hour extraction time；Described concentration densities most preferably 1.07；It is vacuum dried under conditions of most preferably 70 DEG C of the drying means.
The application of the Chinese medicine composition of described treatment osteoporosis, is the pharmaceutical preparation for preparing treatment osteoporosis.
The Chinese medicinal composition preparation of described treatment osteoporosis, is formulation described in any pharmacy.
The Chinese medicinal composition preparation of described treatment osteoporosis, pharmaceutical dosage forms can be any pharmaceutically useful oral agents
Type, these formulations include：Tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, flexible glue
Wafer, oral liquid, mouth containing agent, granule, electuary, pill, powder etc..
The Chinese medicinal composition preparation of described treatment osteoporosis, adds dextrin to mix obtained dry extract, is profit with ethanol
Humectant, granulation is dried, whole grain, that is, granule is obtained.
Application of the described Chinese medicine composition in treatment osteoporosis agents are prepared.
Pharmacodynamics test shows：The Chinese medicine composition of the treatment osteoporosis that the present invention is provided, is remarkably improved osteoporosis big
The overall bone amount and calcium of mouse lumbar vertebra, phosphorus, the content of organic matter, improve bone structure；Effect with good treatment osteoporosis,
And without the obvious side effect of appearance, it is expected to the pharmaceutical preparation for preparing treatment osteoporosis, with prospect in medicine.
The present composition comes from the proved recipe that clinical long-term use confirms effectively treatment osteoporosis, with good treatment bone
The loose effect of matter.Its prescription is by barrenwort, the rhizome of davallia, the Radix Astragali, stir-baked SEMEN PSORALEAE with salt solution, prepared rhizome of rehmannia, Radix Angelicae Sinensis, stir-baked CORTEX EUCOMMIAE with salt solution and vinegar
Tortoise plastron is constituted.Medicinal material barrenwort is the drying of Berberidaceae plant barrenwort, Epimedium sagittatum, E. Pubescens or korean epimedium herb
Leaf, with kidney-replenishing, strengthening the bones and muscles, effect of wind-damp dispelling.Modern study shows that barren wort total chromocor and its metabolite have
Promoting bone growing activity, suppresses the effect that osteoclast beta-actin is produced.The rhizome of davallia is the dry root of fire hose section plant Mongolian oak fern
Stem, with analgesic of curing the wound, effect of The strong bone of kidney tonifying.Process of Total Flavonoids in Drynaria Fortunei is to the osteoporosis animal models caused by ovary excision
Its bone density and blood calcium can be significantly improved.The Radix Astragali is the dry root of legume astragalus mongolicus or Astragalus membranacus, with benefit
Gas lift sun, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, the stagnant arthritis of row, pus draining and toxin expelling, effect of expelling pus and promoting granulation.Modern times grind
Study carefully discovery, astragalus flavonid extract can substantially suppress the bone ore deposit dissolving of the osteoporosis rat that vitamin A acid is caused and lose, moreover it is possible to
The effectively damage of protection reproductive organs, meanwhile, astragalus polyose energy dosage relatively promotes the propagation of rat primary Gegenbaur's cell, divides
Change and mineralising.Psoralea corylifolia is the dry mature fruit of legumes psoraleae, and with warming kidney and enhancing yang, gas of receiving is relievingd asthma, warming spleen and stopping diarrha
The effects such as.The coumarin kind compound extracted in Psoralea corylifolia, psoralen, Isopsoralen have estrogenic activity, energy
Cell ALP activity is significantly improved, increased calcium content, promoted osteocalcin secretion.Glutinous rehmannia is fresh or dry for scrophulariaceae rehmannia glutinosa plant
Dry root tuber, prepared rhizome of rehmannia is the Preparation process product of radix rehmanniae recen, with enriching yin of enriching blood, effect of beneficial to spirit and marrow.Modern study, cultivated land
Yellow and its different compatibility drugs have obvious adjustment effect to bone metabolism of diabetic rats, can dramatically increase diabetes rat tibial bone close
Degree, improves bone calcium, phosphorus content, suppresses generation and the bone resorption activity of osteoclast, can improve the Bone m etabolism in osteoporosis.When
The dry root of umbelliferae angelica is classified as, with replenishing and activating blood, menstruction regulating and pain relieving, the effect for relaxing bowel.Experiment proves Radix Angelicae Sinensis
Polysaccharide can immune cell activated and complement system, promote cell factor generation and antibody generation.The bark of eucommia is Eucommiaceae plant
The dry bark of the bark of eucommia, with filling liver kidney, strengthening the bones and muscles, antiabortive effect.Modern study proves that eucommia ulmoides extracts have class female
Steroids sample is acted on, and is had and is suppressed bone conversion, improve bone density, suppress bone information, the drug action of regulation Bone m etabolism function.Tortoise
First is the carapace and plastron of Testudinidae animal tortoise, with nourishing and suppressing Yang, the strong bone of kidney-nourishing, and blood-nourishing bushing, Gu the effect through only collapsing.
Tortoise plastron enters kidney, Liver Channel, and kidney tonifying, essence replenishing, raw marrow are enriched blood, and modern study shows, is reached by the expression for regulating and controlling retinoic acid receptors RAR
To the propagation for promoting mesenchymal stem cells MSCs MSC, improve the effect of hematopoieticmicroenviron-ment.
Relative to modern technologies, Chinese medicine preparation of the present invention is with broken with promoting bone growing, the barrenwort for suppressing bone differentiation, bone
Benefit, the Radix Astragali, stir-baked SEMEN PSORALEAE with salt solution, prepared rhizome of rehmannia, Radix Angelicae Sinensis, stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron medicinal material are combined for raw material, pharmacodynamic experiment card
Bright Chinese medicine composition of the present invention has the function for the treatment of osteoporosis, and without there is obvious side effect, before medicinal
Scape.
Specific embodiment
The present invention is made with reference to embodiment further illustrate in detail, intactly.
Barrenwort used, the rhizome of davallia, the Radix Astragali, Psoralea corylifolia, prepared rhizome of rehmannia, Radix Angelicae Sinensis, the bark of eucommia and tortoise plastron are accorded with following embodiments
Close the relevant every regulation under each medicinal material of text of Chinese Pharmacopoeia 2010 edition.Each medicinal material by net system, cutting, processing,
The working processes such as crushing, before feeding intake, by identification, ingredients material object is consistent with title, and quality meets NF standard (tool
Body Med Mat Appreciation method is performed with reference to standards of pharmacopoeia).
Embodiment 1
Weigh barrenwort 100g, rhizome of davallia 150g, Radix Astragali 150g, stir-baked SEMEN PSORALEAE with salt solution 150g, prepared rhizome of rehmannia 200g, Radix Angelicae Sinensis 150g, salt
Bark of eucommia 150g and vinegar tortoise plastron 150g, adds water to decoct together and extracts：12 times of amount water are added every time, is decocted 3 times altogether, 1 is decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.07 (20 DEG C)；In the rotating speed of 5000r/min
Lower centrifugation 30 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 2
Weigh barrenwort 200g, rhizome of davallia 300g, Radix Astragali 300g, stir-baked SEMEN PSORALEAE with salt solution 300g, prepared rhizome of rehmannia 400g, Radix Angelicae Sinensis 300g, salt
Bark of eucommia 300g and vinegar tortoise plastron 300g, adds water to decoct together and extracts：12 times of amount water are added every time, is decocted 3 times altogether, 1 is decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.00 (20 DEG C)；In the rotating speed of 5000r/min
Lower centrifugation 30 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 3
Weigh barrenwort 400g, rhizome of davallia 600g, Radix Astragali 600g, stir-baked SEMEN PSORALEAE with salt solution 600g, prepared rhizome of rehmannia 800g, Radix Angelicae Sinensis 600g, salt
Bark of eucommia 600g and vinegar tortoise plastron 600g, adds water to decoct together and extracts：15 times of amount water being added every time, being decocted 3 times altogether, 1.5 are decocted every time
Hour；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.10 (20 DEG C)；In turning for 6000r/min
The lower centrifugation of speed 20 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 4
Weigh barrenwort 200g, rhizome of davallia 300g, Radix Astragali 300g, stir-baked SEMEN PSORALEAE with salt solution 300g, prepared rhizome of rehmannia 400g, Radix Angelicae Sinensis 300g, salt
Bark of eucommia 300g and vinegar tortoise plastron 300g, adds water to decoct together and extracts：12 times of amount water are added every time, is decocted 2 times altogether, 1 is decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.30 (20 DEG C)；In the rotating speed of 6000r/min
Lower centrifugation 30 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 5
Weigh barrenwort 400g, rhizome of davallia 600g, Radix Astragali 600g, stir-baked SEMEN PSORALEAE with salt solution 600g, prepared rhizome of rehmannia 800g, Radix Angelicae Sinensis 600g, salt
Bark of eucommia 600g and vinegar tortoise plastron 600g, adds water to decoct together and extracts：15 times of amount water are added every time, is decocted 1 time altogether, 1 is decocted every time small
When；Merge extract solution, filtering, Aqueous extracts are concentrated into relative density for 1.40 (20 DEG C)；20 are centrifuged under the rotating speed of 6000r/min
Minute；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 6
Weigh barrenwort 200g, rhizome of davallia 300g, Radix Astragali 300g, stir-baked SEMEN PSORALEAE with salt solution 300g, prepared rhizome of rehmannia 400g, Radix Angelicae Sinensis 300g, salt
Bark of eucommia 300g and vinegar tortoise plastron 300g, adds water to decoct together and extracts：12 times of amount water are added every time, is decocted 3 times altogether, 1 is decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.20 (20 DEG C)；In the rotating speed of 5000r/min
Lower centrifugation 30 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 7
Weigh barrenwort 67g, rhizome of davallia 100g, Radix Astragali 100g, stir-baked SEMEN PSORALEAE with salt solution 100g, prepared rhizome of rehmannia 134g, Radix Angelicae Sinensis 100g, salt Du
Secondary 100g and vinegar tortoise plastron 100g, adds water to decoct together and extracts：12 times of amount water are added every time, is decocted 3 times altogether, 0.5 is decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.10 (20 DEG C)；In the rotating speed of 6000r/min
Lower centrifugation 20 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 8
Weigh barrenwort 800g, rhizome of davallia 10000g, Radix Astragali 10000g, stir-baked SEMEN PSORALEAE with salt solution 10000g, prepared rhizome of rehmannia 20000g, Radix Angelicae Sinensis
10000g, stir-baked CORTEX EUCOMMIAE with salt solution 10000g and vinegar tortoise plastron 100g, add water to decoct together and extract：12 times of amount water are added every time, are decocted 3 times altogether,
Decoct 2 hours every time；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.30 (20 DEG C)；In 6000r/min
Rotating speed under be centrifuged 20 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 9
Weigh barrenwort 400g, rhizome of davallia 600g, Radix Astragali 600g, stir-baked SEMEN PSORALEAE with salt solution 600g, prepared rhizome of rehmannia 600g, Radix Angelicae Sinensis 600g, salt
Bark of eucommia 600g and vinegar tortoise plastron 600g, adds water to decoct together and extracts：15 times of amount water are added every time, is decocted 3 times altogether, 1 is decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.60 (20 DEG C)；In the rotating speed of 5000r/min
Lower centrifugation 15 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 10
Weigh barrenwort 400g, rhizome of davallia 600g, Radix Astragali 10g, stir-baked SEMEN PSORALEAE with salt solution 100g, prepared rhizome of rehmannia 800g, Radix Angelicae Sinensis 100g, salt Du
Secondary 100g and vinegar tortoise plastron 100g, adds water to decoct together and extracts：12 times of amount water are added every time, is decocted 3 times altogether, 1.5 are decocted every time small
When；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.70 (20 DEG C)；In the rotating speed of 5000r/min
Lower centrifugation 10 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 11
Weigh barrenwort 100g, rhizome of davallia 350g, Radix Astragali 350g, stir-baked SEMEN PSORALEAE with salt solution 350g, prepared rhizome of rehmannia 240g, Radix Angelicae Sinensis 350g, salt
Bark of eucommia 350g and vinegar tortoise plastron 100g, adds water to decoct together and extracts：8 times of amount water are added every time, is decocted 3 times altogether, decoct 2 hours every time；
Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.80 (20 DEG C)；Under the rotating speed of 8000r/min from
The heart 20 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 12
Weigh barrenwort 80g, rhizome of davallia 600g, Radix Astragali 350g, stir-baked SEMEN PSORALEAE with salt solution 350g, prepared rhizome of rehmannia 350g, Radix Angelicae Sinensis 240g, salt Du
Secondary 240g and vinegar tortoise plastron 90g, adds water to decoct together and extracts：15 times of amount water are added every time, is decocted 1 time altogether, decoct 2 hours every time；
Merge and decoct extract solution, filtering, Aqueous extracts are concentrated into relative density for 1.50 (20 DEG C)；15 are centrifuged under the rotating speed of 6000r/min
Minute；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 13
Weigh barrenwort 400g, rhizome of davallia 3500g, Radix Astragali 600g, stir-baked SEMEN PSORALEAE with salt solution 240g, prepared rhizome of rehmannia 800g, Radix Angelicae Sinensis 160g, salt
Bark of eucommia 100g and vinegar tortoise plastron 100g, adds water to decoct together and extracts：8 times of amount water are added every time, is decocted 3 times altogether, decoct 2 hours every time；
Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.90 (20 DEG C)；Under the rotating speed of 6000r/min from
The heart 20 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 14
Weigh the weight portion of barrenwort 67, the weight portion of the rhizome of davallia 150, the weight portion of the Radix Astragali 150, the weight portion of stir-baked SEMEN PSORALEAE with salt solution 150, prepared rhizome of rehmannia
150 weight portions, the weight portion of Radix Angelicae Sinensis 150, the weight portion of stir-baked CORTEX EUCOMMIAE with salt solution 150 and the weight portion of vinegar tortoise plastron 53, add water to decoct together and extract：Every time
12 times of amount water are added, is decocted 3 times altogether, decocted 2 hours every time；Merge and decoct extract solution, filtering, Aqueous extracts are concentrated into relatively close
It is 2.00 (20 DEG C) to spend；It is centrifuged 10 minutes under the rotating speed of 8000r/min；In 70 DEG C of vacuum drying, dry extract is obtained.
Embodiment 15
Weigh barrenwort 100g, rhizome of davallia 350g, Radix Astragali 320g, stir-baked SEMEN PSORALEAE with salt solution 350g, prepared rhizome of rehmannia 200g, Radix Angelicae Sinensis 120g, salt
Bark of eucommia 320g and vinegar tortoise plastron 120g, adds water to decoct together and extracts：10 times of amount water being added every time, being decocted 3 times altogether, 1.5 are decocted every time
Hour；Merge 3 decoction extract solutions, filtering, Aqueous extracts are concentrated into relative density for 1.10 (20 DEG C)；In turning for 7000r/min
The lower centrifugation of speed 30 minutes；In 70 DEG C of vacuum drying, dry extract is obtained.
Any one dry extract that above-described embodiment 1-15 is obtained is crushed, and adds appropriate soluble starch, dextrin mixing, with
Ethanol is wetting agent, granulation, is dried, and whole grain can be obtained granule；Or any one for obtaining above-described embodiment 1-15
Dry extract is crushed, and adds appropriate superfine silica gel powder, microcrystalline cellulose mixing, and with ethanol as wetting agent, granulation is dried, whole grain,
It is encapsulated, capsule can be obtained；Or any one dry extract for obtaining above-described embodiment 1-15 is crushed, add appropriate solvable
Property starch, dextrin mixing, with ethanol as wetting agent, granulation is dried, and whole grain, compressing tablet can be obtained tablet；Or to above-mentioned
Suitable amount of sucrose, essence mixing are added in concentrate after any one centrifugation that embodiment 1-15 is obtained, sterilizing is filling, can make
Obtain oral liquid.
Below the preferred embodiment to the invention is illustrated, but the invention is not limited to described implementation
Example, those of ordinary skill in the art can also make a variety of equivalent modifications on the premise of without prejudice to the invention spirit
Or replace, these equivalent modifications or replacement are all contained in the application claim limited range.
Claims (10)
1. a kind of Chinese medicine composition for treating osteoporosis, it is characterised in that merged by the bulk drug of following masses part and extracted
It is prepared from：8~40 parts of barrenwort, 10~60 parts of the rhizome of davallia, 10~60 parts of the Radix Astragali, 10~60 parts of stir-baked SEMEN PSORALEAE with salt solution, prepared rhizome of rehmannia
10~60 parts of 15~80 parts, 8~40 parts of Radix Angelicae Sinensis, 10~60 parts of stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron.
2. the Chinese medicine composition for the treatment of osteoporosis according to claim 1, it is characterised in that by following masses part
Bulk drug merge extraction be prepared from：10~25 parts of barrenwort, 20~40 parts of the rhizome of davallia, 20~40 parts of the Radix Astragali, stir-baked SEMEN PSORALEAE with salt solution
20~40 parts of 20~40 parts, 20~60 parts of prepared rhizome of rehmannia, 10~25 parts of Radix Angelicae Sinensis, 20~40 parts of stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron.
3. the Chinese medicine composition for the treatment of osteoporosis according to claim 2, it is characterised in that by following masses part
Bulk drug merge extraction be prepared from：It is 10 parts of barrenwort, 15 parts of the rhizome of davallia, 15 parts of the Radix Astragali, 15 parts of stir-baked SEMEN PSORALEAE with salt solution, ripe
15 parts of 20 parts of glutinous rehmannia, 10 parts of Radix Angelicae Sinensis, 15 parts of stir-baked CORTEX EUCOMMIAE with salt solution and vinegar tortoise plastron.
4. a kind of preparation method of the Chinese medicine composition of the treatment osteoporosis described in claim 1, it is characterised in that bag
Include following steps：Each composition Chinese medicine is weighed by proportioning, is added water to decoct together and is extracted, merged and decoct extract solution, filtering, concentration,
Centrifugation, dries, and dry extract is obtained.
5. it is according to claim 4 treatment osteoporosis Chinese medicine composition preparation method, it is characterised in that：Plus
During water boiling and extraction, the volume that adds water every time is 8~15 times of medicinal material gross mass, and each extraction time is 0.5~2 hour, is extracted
Number of times is 1~3 time.
6. it is according to claim 4 treatment osteoporosis Chinese medicine composition preparation method, it is characterised in that：It is dense
It is 1.0~2.0 to be reduced to the relative density at 20 DEG C.
7. it is according to claim 4 treatment osteoporosis Chinese medicine composition preparation method, it is characterised in that：Institute
The centrifugation stated is centrifuged 10~30 minutes under the rotating speed of 5000~8000r/min.
8. it is according to claim 4 treatment osteoporosis Chinese medicine composition preparation method, it is characterised in that：Institute
The drying stated is for spray drying or is vacuum dried, and drying temperature is 60~80 DEG C.
9. application of the Chinese medicine composition as described in claims 1 to 3 is any in prevention or treatment osteoporosis agents is prepared.
10. the Chinese medicine composition for the treatment of osteoporosis according to claim 9 is preparing prevention or is treating osteoporosis
Application in medicine, it is characterised in that described medicine be using the Chinese medicine composition as described in claims 1 to 3 is any as
Active ingredient and pharmaceutic adjuvant are made pharmaceutical preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510919775.3A CN106860656A (en) | 2015-12-11 | 2015-12-11 | It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510919775.3A CN106860656A (en) | 2015-12-11 | 2015-12-11 | It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106860656A true CN106860656A (en) | 2017-06-20 |
Family
ID=59177332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510919775.3A Pending CN106860656A (en) | 2015-12-11 | 2015-12-11 | It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106860656A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272943A (en) * | 2018-03-08 | 2018-07-13 | 广东安诺药业股份有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating osteoporotic fracture |
| CN114767764A (en) * | 2022-04-21 | 2022-07-22 | 董万涛 | Traditional Chinese medicine prescription for osteoporosis and preparation method thereof |
-
2015
- 2015-12-11 CN CN201510919775.3A patent/CN106860656A/en active Pending
Non-Patent Citations (5)
| Title |
|---|
| 施杞: "《中国中医药年鉴. 2000》", 31 January 2001, 中医药出版社 * |
| 李向高: "《中药材加工学》", 31 January 2004, 中国农业出版社 * |
| 范晓楠等: "骨松灵颗粒质量标准研究", 《世界中医药》 * |
| 赵雷等: "骨松灵汤治疗骨质疏松症疗效观察", 《山东医药》 * |
| 陆兔林等: "《中药炮制学》", 30 June 2013, 上海科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272943A (en) * | 2018-03-08 | 2018-07-13 | 广东安诺药业股份有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating osteoporotic fracture |
| CN108272943B (en) * | 2018-03-08 | 2021-03-30 | 广东安诺药业股份有限公司 | A pharmaceutical composition for treating osteoporotic fracture, and its preparation method |
| CN114767764A (en) * | 2022-04-21 | 2022-07-22 | 董万涛 | Traditional Chinese medicine prescription for osteoporosis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101513437B (en) | Antifatigue Chinese pharmaceutical composition and preparation method thereof | |
| CN103340341B (en) | Functional food with bone strengthening effect and preparation method thereof | |
| CN1139396C (en) | Life essence-filling, marrow-benefitting and kidney invigorating Chinese medicine preparation | |
| CN104306959A (en) | Medicine composition for treating osteoporosis and preparation method thereof | |
| CN101062080B (en) | Medicinal composition for relieving fatigue and preparing process thereof | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN109602836A (en) | Hippocampus multiple penis pill and preparation method thereof | |
| CN101491343A (en) | Health product capable of increasing human immunity and preparation method thereof | |
| CN1284567C (en) | Medicinal liquid for treating osteoporosis and its preparation method | |
| CN103110762A (en) | Traditional Chinese medicine composition for treating old fracture | |
| CN104825528B (en) | Have effects that increase the composition and its preparation method and application of bone density | |
| CN1907316A (en) | Orthopaedics disease treating and preventing medicinal composition | |
| CN104800720A (en) | Medicine for improving sexual desire of breeding bull and increasing yield of semen and preparation method of medicine | |
| CN102671178A (en) | Chinese medicinal composition for treating nephrotic syndrome and uremia and preparation method and application thereof | |
| CN1742775A (en) | Medicine composition for preventing and treating orthopedic diseases | |
| CN106860656A (en) | It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application | |
| CN107375605A (en) | Semifluid extract of deer foetus and preparation method thereof | |
| CN102114070B (en) | Compound traditional Chinese medicine for treating osteoporosis and preparation method thereof | |
| CN104257839B (en) | A kind of Chinese medicine composition with hypoglycemic protection blood vessel endothelium effect and preparation method thereof | |
| CN104524524B (en) | Medicine treating osteoporosis and preparing method | |
| CN105853689A (en) | Application of green plum extract to preparation of health care product for treating osteoporosis | |
| CN101934046B (en) | Semifluid extract of deer foetus and preparation method thereof | |
| CN105012507A (en) | Traditional Chinese medicine composition for treating osteoporosis and preparation method of traditional Chinese medicine composition | |
| CN104758534A (en) | Medicine for treating osteoporosis and preparing method thereof | |
| CN103705831B (en) | A kind of pharmaceutical composition treating menopausal syndrome and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170620 |
|
| RJ01 | Rejection of invention patent application after publication |