CN114767764A - Traditional Chinese medicine prescription for osteoporosis and preparation method thereof - Google Patents
Traditional Chinese medicine prescription for osteoporosis and preparation method thereof Download PDFInfo
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- CN114767764A CN114767764A CN202210422122.4A CN202210422122A CN114767764A CN 114767764 A CN114767764 A CN 114767764A CN 202210422122 A CN202210422122 A CN 202210422122A CN 114767764 A CN114767764 A CN 114767764A
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Abstract
The invention discloses a Chinese medicinal prescription for treating osteoporosis and a preparation method thereof, wherein the Chinese medicinal prescription comprises the following components: 30 g of radix astragali preparata, 12 g of angelica, 12 g of codonopsis pilosula, 12 g of prepared rehmannia root, 9 g of cistanche, 9 g of fructus psoraleae, 9 g of herba epimedii preparata, 12 g of rhizoma cibotii preparata, 3 g of deerhorn glue, 9 g of radix linderae and 9 g of ground beetle. The medicines are combined to play the effects of tonifying spleen and kidney, warming yang and benefiting qi, and activating blood circulation to remove meridian obstruction, and can effectively improve OP.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine prescription for osteoporosis and a preparation method thereof.
Background
With the accelerated aging process of the global population and the prolonged life of human beings, the incidence rate of Osteoporosis (OP) is higher and higher, and the OP becomes a major public health problem influencing the quality of life of the elderly population in China and the financial burden of society.
The drugs currently on the market for the treatment of OP: (1) the bisphosphonate medicines can increase the bone mass, effectively inhibit the activity of osteoclast, hinder the bone transformation, prolong the bone mineralization time, reduce the damage of bone trabecula, increase the accumulation of bone matrix collagen, improve the bone quality and reduce the fracture risk. The main representatives of the drugs are: the representative drugs are alendronate sodium and risedronate sodium. However, long-term use of zoledronate or adverse reactions such as serum creatinine increase and fever are not suitable for long-term administration. (2) Calcitonin class of drugs: the calcitonin drug acts on osteoclasts, accelerates apoptosis, improves bone structure of patients, and increases bone calcium content of the patients, and the representative drug is salmon calcitonin, but because of drug dosage and other reasons, nausea, vomit, dizziness, anaphylaxis and the like appear in some patients. (3) Estrogen replacement therapy: the estrogen replacement therapy can improve the symptoms of postmenopausal women caused by hypoovarianism, decreased secretion of endogenous estrogen, large loss of calcium ions, decreased estrogen receptor on osteocyte, short circuit between bone absorption and bone formation, increase deep vein thrombosis, increase cardiovascular disease risk and risk of breast cancer and endometrial cancer.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine prescription for osteoporosis and a preparation method thereof, so as to solve the technical problems.
In order to solve the technical problems, the invention adopts the following technical scheme:
a Chinese medicinal formulation for osteoporosis comprising: 30 g of radix astragali preparata, 12 g of angelica, 12 g of codonopsis pilosula, 12 g of prepared rehmannia root, 9 g of cistanche, 9 g of fructus psoraleae, 9 g of herba epimedii preparata, 12 g of rhizoma cibotii preparata, 3 g of deerhorn glue, 9 g of radix linderae and 9 g of ground beetle.
A preparation method of a traditional Chinese medicine prescription for osteoporosis comprises the following steps:
(1) cleaning radix astragali Preparata, radix Angelicae sinensis, radix Codonopsis, radix rehmanniae Preparata, Cistanchis herba, fructus Psoraleae, herba Epimedii Preparata, rhizoma Cibotii, colla Cornus Cervi, radix Linderae, and Eupolyphaga Seu Steleophaga, inserting multiple thin steel tubes into the above Chinese medicinal materials, opening multiple holes on the thin steel tubes, fixing a filter screen on the holes, placing into a Chinese medicinal boiling pot, adding water, and pre-steaming for three minutes;
(2) after the pre-cooking is finished, pouring water in the cooking pot, and adding clear water again for cooking for one hour;
(3) after cooking, taking out the thin steel tube inserted into the traditional Chinese medicine, then extruding the traditional Chinese medicine by using a pressing plate, extruding the medicine juice in the traditional Chinese medicine, then putting the extruded medicine juice into a cooking pot, and taking out and storing the liquid medicine in the cooking pot;
(4) and (3) reinserting the cooked traditional Chinese medicine into the thin steel tube in the step (1), and then putting the thin steel tube into a cooking pot for secondary cooking.
Preferably, in the step (1), the whole of the processed astragalus, the angelica, the codonopsis pilosula, the prepared rehmannia root, the cistanche deserticola, the fructus psoraleae, the processed epimedium herb, the scalded rhizoma cibotii, the deer horn glue, the combined spicebush root and the ground beeltle are put into a cooking pot without cutting.
Preferably, in the step (2), after the pre-cooking is finished, the traditional Chinese medicine is cleaned, and residues in the cooking pot are removed.
Preferably, in the step (3), the traditional Chinese medicine should be kept intact when being squeezed.
Preferably, in the step (4), when the cooked traditional Chinese medicine is reinserted into the thin steel tube, the traditional Chinese medicine is prevented from being inserted into the thin steel tube.
The invention has the beneficial effects that:
in the formula, the roasted astragalus root has the effects of tonifying qi and spleen, the Chinese angelica has the effects of enriching blood and activating blood, the astragalus root has sweet and thin taste, and the effects of tonifying spleen and tonifying qi are slightly better; dang Gui is sweet and heavy in flavor, so it can tonify blood. The composition is used together with radix astragali Preparata as principal drug for invigorating qi, invigorating spleen, replenishing blood, and promoting blood circulation. The codonopsis pilosula has the effects of harmonizing medicine property, strengthening the middle-jiao and replenishing qi, and strengthening the spleen-tonifying power, and the codonopsis pilosula is matched with the astragalus and the angelica to enhance the effects of replenishing qi and enriching the blood of the astragalus and the angelica; prepared rehmannia root, radix rehmanniae Praeparata has the effects of replenishing blood, nourishing yin, replenishing essence and benefiting marrow, and Chinese angelica root, radix rehmanniae Praeparata has the effect of replenishing blood when being mutually reinforced, so the effect of replenishing blood is better; cistanchis herba has effects of invigorating kidney yang, replenishing essence and blood, loosening bowel to relieve constipation, and enhancing the effect of radix rehmanniae Preparata in invigorating kidney and marrow. The three medicines are used together as ministerial medicines to regulate yin and yang, replenish essence and benefit marrow. Fructus Psoraleae and herba Epimedii have effects in warming kidney yang, strengthening tendons and bones, warming rhizoma Cibotii, invigorating liver and kidney, replenishing essence, nourishing marrow, strengthening yang, invigorating spleen and kidney, nourishing blood and essence, and warming tendons and bones; the four herbs are used together as adjuvant drugs to warm kidney yang, replenish essence and marrow, strengthen waist and knees. Radix Linderae has effects of regulating qi, dispelling cold, relieving pain, and guiding the herbs into lower energizer; the ground beetle breaks blood and removes stasis, reunites tendons and bones, and the two medicines are used together as a guiding drug to make the whole formula tonify without stagnation. Therefore, the medicines are combined to play the effects of tonifying spleen and kidney, warming yang and benefiting qi, and activating blood circulation to remove meridian obstruction, and can effectively improve OP.
Detailed Description
The present invention will be further described with reference to specific embodiments for the purpose of facilitating an understanding of technical means, characteristics of creation, objectives and functions realized by the present invention, but the following embodiments are only preferred embodiments of the present invention, and are not intended to be exhaustive. Other embodiments obtained by persons skilled in the art without making creative efforts based on the embodiments in the implementation belong to the protection scope of the invention. The experimental procedures in the following examples were carried out in a conventional manner unless otherwise specified, and materials, reagents and the like used in the following examples were commercially available unless otherwise specified.
A Chinese medicinal formula for treating osteoporosis and a preparation method thereof, comprises the following steps: 30 g of radix astragali preparata, 12 g of angelica, 12 g of codonopsis pilosula, 12 g of prepared rehmannia root, 9 g of cistanche, 9 g of fructus psoraleae, 9 g of herba epimedii preparata, 12 g of rhizoma cibotii preparata, 3 g of deerhorn glue, 9 g of radix linderae and 9 g of ground beetle.
A preparation method of a traditional Chinese medicine prescription for osteoporosis comprises the following steps:
(1) cleaning radix astragali Preparata, radix Angelicae sinensis, radix Codonopsis, radix rehmanniae Preparata, Cistanchis herba, fructus Psoraleae, herba Epimedii Preparata, rhizoma Cibotii, colla Cornus Cervi, radix Linderae, and Eupolyphaga Seu Steleophaga, inserting multiple thin steel tubes into the above Chinese medicinal materials, forming multiple openings on the thin steel tubes, fixing a filter screen on the openings, placing into a Chinese medicinal decocting pot, adding water, and pre-decocting for three minutes; radix astragali Preparata, radix Angelicae sinensis, radix Codonopsis, radix rehmanniae Preparata, Cistanchis herba, fructus Psoraleae, herba Epimedii Preparata, rhizoma Cibotii preparata, colla Cornus Cervi, radix Linderae, and Eupolyphaga Seu Steleophaga by placing into a cooking pot without cutting.
(2) After the pre-cooking is finished, pouring water in the cooking pot, and adding clear water again for cooking for one hour; after the pre-cooking is finished, the traditional Chinese medicines are cleaned, and residues in the cooking pot are removed.
(3) After cooking, taking out the thin steel tube inserted into the traditional Chinese medicine, then extruding the traditional Chinese medicine by using a pressing plate, extruding the medicine juice in the traditional Chinese medicine, then putting the extruded medicine juice into a cooking pot, and taking out and storing the liquid medicine in the cooking pot; when squeezing the Chinese herbs, the Chinese herbs should be kept intact.
(4) And (3) reinserting the cooked traditional Chinese medicine into the thin steel tube in the step (1), and then putting the thin steel tube into a cooking pot for secondary cooking. When re-inserting the steamed Chinese medicinal materials into the thin steel tube, the insertion of the Chinese medicinal materials into the thin steel tube is avoided.
218 patients from 218 patients diagnosed as senile primary osteoporosis at the affiliated hospital of traditional Chinese medicine university in Gansu from 2017, 6 months to 2018, 1 month were randomly divided into the present invention group (109 cases) and a bone health supplement group (109 cases), and the bone health supplement group was administered with 1 tablet/time, 1/D, of calcium carbonate D3 chewable tablets; calcitriol capsules are 1 pill/time, 1 time/d, 4 weeks are 1 treatment course, 6 treatment courses are totally treated, the recorded formula is given on the basis of treatment of a bone health supplement group, 1 dose is taken every day, the capsules are decocted with water, the capsules are taken 1 time respectively in the morning and at night, 4 weeks are 1 treatment course, the curative effect is determined after 6 treatment courses are observed, the curative effect is evaluated by adopting VAS (blood pressure of vital energy system) scores, Chinese medicine symptom scores and bone density values, and the occurrence condition of adverse reactions is observed.
The effective rate of the invention group after treatment is 94.50 percent which is obviously higher than 85.32 percent of the positive drug control group (P is less than 0.05);
TABLE 2 clinical efficacy comparison of two groups of OP patients [ n (%) ]
Table 2 Comparison of efficacy between the two groups[n(％)]
| Group of | Number of examples | Show effect | Is effective | Nullification | Total effective rate |
| Bone health supplement group | 109 | 25(22.94) | 68(62.26) | 16(14.68) | 93(85.32) |
| Group of the invention | 109 | 31(8.44) | 72(66.06) | 6(8.26) | 105(94.50＊) |
Note: p < 0.05 compared to the bone health supplement group.
Comparison of VAS scores before and after treatment in two groups of patients
After treatment, VAS scores were reduced in both groups compared to those before treatment (P both < 0.05), but the group of the invention was significantly lower than the bone health supplement group (P < 0.05) as shown in Table 3.
Table 3 two groups of patients VAS score comparison (
Minute)
Table 3 Comparison of the change of VAS score between the two groups(
score2)
| Group of | Number of examples | Before treatment | After treatment |
| Bone health supplement group | 109 | 4.7±0.5 | 1.9±0.5＊ |
| Group of the invention | 109 | 5.1±0.4 | 1.3±0.6＊# |
Note: p < 0.05 compared to pre-treatment; compared to the group of bone health supplements, # P < 0.05.
Comparison of bone density values before and after treatment in two groups of patients
After treatment, BMD was higher in both groups than before treatment (P < 0.05), but the present group was significantly higher than the bone health supplement group (P < 0.05), as shown in Table 4.
TABLE 4 comparison of BMD values before and after treatment in two groups of patients: (
g/cm2)
Table 4 Comparison of the change of BMD value between the two groups(
g/cm2)
| Group of | Number of examples | Time | Femoral neck BMD | Femoral trochanter BMD |
| Bone health supplement group | 109 | Before treatment | 0.57±0.21 | 0.51±0.13 |
| After treatment | 0.65±0.19＊ | 0.64±0.14＊ | ||
| Group of the invention | 109 | Before treatment | 0.55±0.18 | 0.48±0.17 |
| After treatment | 0.74±025＊Δ | 0.71±0.15＊Δ |
Note: p < 0.05 compared to pre-treatment; compared to the group of bone health supplements, # P < 0.05.
Integral comparison of Chinese medicine symptoms before and after treatment of two groups of patients
After treatment, the scores of the main symptoms of spleen-kidney yang deficiency caused by 0P in two groups of patients are obviously reduced compared with the scores before treatment (P is less than 0.05), but the score of the group of the invention is reduced more obviously (P is less than 0.05) compared with the group of bone health supplements, and the table 5 shows.
TABLE 5 comparison of the integrals of the symptoms of TCM for two groups of patients: (
Minute)
Table 5 Comparison ofthe change of TCM syndromes between the two groups(
score)
| Group of | Pain of the back and waist | Increase in nocturia | Soreness and weakness of waist and knees | Mental fatigue and lassitude | Aversion to cold and cold limbs |
| Bone health supplement group (n ═ 109) | |||||
| Before treatment | 2.41±0.55 | 1.07±0.29 | 1.36±0.62 | 1.12±0.34 | 1.37±0.38 |
| After treatment | 2.15±0.41＊ | 0.68±0.27＊ | 0.88±0.34＊ | 0.72±0.21＊ | 0.84±0.21＊ |
| Inventive group (n ═ 109) | |||||
| Before treatment | 2.37±0.57 | 1.12±0.25 | 1.38±0.64 | 1.18±0.27 | 1.14±0.47 |
| After treatment | 1.45±0.39＊# | 0.56±0.22＊# | 0.54±0.32＊# | 0.42±0.25＊# | 0.47±0.14＊# |
Note: p < 0.05 compared to pre-treatment; compared to the bone health supplement group post treatment, # P < 0.05.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. A traditional Chinese medicine prescription for osteoporosis is characterized in that: the method comprises the following steps: 30 g of radix astragali preparata, 12 g of angelica, 12 g of codonopsis pilosula, 12 g of prepared rehmannia root, 9 g of cistanche, 9 g of fructus psoraleae, 9 g of herba epimedii preparata, 12 g of rhizoma cibotii preparata, 3 g of deerhorn glue, 9 g of radix linderae and 9 g of ground beetle.
2. A preparation method of a traditional Chinese medicine prescription for osteoporosis is characterized in that: the method comprises the following steps:
(1) cleaning radix astragali Preparata, radix Angelicae sinensis, radix Codonopsis, radix rehmanniae Preparata, Cistanchis herba, fructus Psoraleae, herba Epimedii Preparata, rhizoma Cibotii, colla Cornus Cervi, radix Linderae, and Eupolyphaga Seu Steleophaga, inserting multiple thin steel tubes into the above Chinese medicinal materials, opening multiple holes on the thin steel tubes, fixing a filter screen on the holes, placing into a Chinese medicinal boiling pot, adding water, and pre-steaming for three minutes;
(2) after the pre-cooking is finished, pouring water in the cooking pot, and adding clear water again for cooking for one hour;
(3) after cooking, taking out the thin steel tube inserted into the traditional Chinese medicine, then extruding the traditional Chinese medicine by using a pressing plate, extruding the medicine juice in the traditional Chinese medicine, then putting the extruded medicine juice into a cooking pot, and taking out and storing the liquid medicine in the cooking pot;
(4) and (2) re-inserting the cooked traditional Chinese medicine into the thin steel tube in the step (1), and then putting the thin steel tube into a cooking pot for secondary cooking.
3. The process for the preparation of a Chinese medicinal formulation for osteoporosis of claim 2, wherein: in the step (1), the roasted astragalus, the angelica, the codonopsis pilosula, the prepared rehmannia root, the cistanche, the fructus psoraleae, the roasted epimedium herb, the scalded rhizoma cibotii, the deer horn glue, the combined spicebush root and the ground beeltle are not cut before being put into a cooking pot, and the whole is required to be put into the cooking pot.
4. The process for the preparation of a Chinese medicinal formulation for osteoporosis of claim 2, wherein: in the step (2), after the pre-cooking is finished, the traditional Chinese medicine is cleaned, and residues in the cooking pot are removed.
5. The process for the preparation of a Chinese medicinal formulation for osteoporosis of claim 2, wherein: in the step (3), the traditional Chinese medicine is kept intact when being squeezed.
6. The method for preparing a Chinese medicinal formulation for osteoporosis of claim 2, wherein the formulation comprises: in the step (4), when the boiled traditional Chinese medicine is inserted into the thin steel tube again, the situation that the traditional Chinese medicine is inserted into the thin steel tube before the thin steel tube is inserted is avoided.
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| CN106860656A (en) * | 2015-12-11 | 2017-06-20 | 中国人民解放军第二军医大学 | It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application |
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