CN106361947A - Preparation method of traditional Chinese medicine for treating osteoporosis - Google Patents

Preparation method of traditional Chinese medicine for treating osteoporosis Download PDF

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CN106361947A
CN106361947A CN201610975262.9A CN201610975262A CN106361947A CN 106361947 A CN106361947 A CN 106361947A CN 201610975262 A CN201610975262 A CN 201610975262A CN 106361947 A CN106361947 A CN 106361947A
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medicine
chinese medicine
decoct
traditional chinese
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姜迪蛟
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Chengdu Ling Xi Luxuries Technology Co Ltd
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Chengdu Ling Xi Luxuries Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a preparation method of a traditional Chinese medicine for treating osteoporosis. The preparation method comprises the following steps: weighing 15-23 parts of Psychotria Serpens, 14-20 parts of Chinese photinia leaf, 10-16 parts of Philippine flemingia root, 16-24 parts of radix achyranthis bidentatae, 17-23 parts of Thladiantha dubia, 13-19 parts of Semiliquidambar cathayensis, 18-24 parts of Chinese holly fruit, 16-22 parts of salvia chinensis, 10-16 parts of Streptopus obtusatus Fassett., 12-20 parts of Abelia biflora, 15-23 parts of phoenix hawksbeard root, 12-20 parts of Aralia echinocaulis and 15-19 parts of Sambucus thunbergiana; soaking all the above traditional Chinese medicine active pharmaceutical ingredients in clear water or pure water; adding the soaked traditional Chinese medicine active pharmaceutical ingredients in a decocting container, and decocting; and after the decocting process is completed, filtering out the liquor, wherein the obtained liquor is the medicine for oral administration. The traditional Chinese medicine disclosed by the invention is based on the understanding and treatment principles on the osteoporosis mechanism, is taken in a direct oral administration manner to realize reinforcement and elimination in combination, has the effects of reinforcing bones and muscles and treating rheumatism, and achieves the advantages of remarkable curative effect, easy quality control, favorable stability and basically no adverse effect.

Description

One kind is used for treating osteoporotic Chinese medicinal preparation method
Technical field
The present invention relates to the field of Chinese medicines, specifically, it is that one kind is used for treating osteoporotic Chinese medicinal preparation method.
Background technology
Osteoporosis are broadly divided into constitutional and Secondary cases, and constitutional, in addition to idiopathic, is divided into i type and ii type, i type is again Referred to as postmenopausal osteoporosiss, are high conversion type, and main cause lacks for estrogen；Ii type is also called senile sclerotin and dredges Pine, is low conversion type, aging due to the age.Caused by many factors, its basic pathology mechanism is bone generation to osteoporosis During thanking, defect in bone resorption and osteoplastic coupling, lead to the alcium and phosphor metabolization in human body uneven, make bone density gradually The clinical symptoms reducing and causing.And osteoporosis fracture may be caused, clinically have for preventing and treating osteoporotic medicine: Calcium preparation, include escape happy, Kai Sili, your strange d of calcium, happy power, calcium gluconate oral solution with effect, imperial prosperous calcium+d oral liquid, strength obtain Calcium, huge energy calcium and micro-calcium；Suppression bone resorption medicine, heir as pregnant in dehydrogenation, Premarin Tablet and livial etc.；Bisphosphonates, such as Fosamax, bone unicorn, Bang get Lin and Ji Li oxazepan；Osteogenic treatment medicine, such as tridin；Promote the vitamin medicaments of mineralising, such as Method can (l Alpha-hydroxy vitamin d3), Rocaltrol (calitriol), Bon-One (alfacalcidol), vertical celebrating (Alfacalcidol Tablets).This Class medicine mostly shields and strengthens Absorption, function not comprehensively it is difficult to complication after preventing and treating osteoporosises, and Easily there is side effect reaction, be unfavorable for healthy.
Content of the invention
It is an object of the invention to provide a kind of evident in efficacy, have no side effect, complete function, be capable of being used for of building body Treat osteoporotic Chinese medicinal preparation method.
The present invention is achieved through the following technical solutions: one kind is used for treating osteoporotic Chinese medicinal preparation method, including with Under several steps:
Step s1: in parts by weight, weigh 15 ~ 23 parts of Ramulus et Folium Psychotriae Serpentis, 14 ~ 20 parts of Folium Photiniae (Folium Photiniae serrulatae), 10 ~ 16 parts of Radix Flemingiae Philippinensiss, Radix Achyranthis Bidentatae 16 ~ 24 Part, red 17 ~ 23 parts, 13 ~ 19 parts of Pterospermi Heterophylli, 18 ~ 24 parts of Fructus Ilicis Cornutae, 16 ~ 22 parts of Radix Salviae Plectranthoidiss, 10 ~ 16 parts of JIZHUASHEN, Fructus Abeliae biflorae 12 ~ 20 parts, 15 ~ 23 parts of Crepis crocea Babc.(C.turczaninowii C.A.Mey.), 12 ~ 20 parts of redwood, 15 ~ 19 parts of Rhizoma seu Herba Elatostematis stewardii；
Step s2: above-mentioned whole raw material of Chinese medicine medicines use in advance clear water or pure water to soak 30 minutes, water consumption for immersion is 0.9 ~ 1.1l；
Step s3: the liquid medicine of the raw material of Chinese medicine medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct；
Step s4: first make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine ~ 3 times；
Step s5: after the completion of decoction, leach medicinal liquid, obtained medicinal liquid is endo-medicine.
Described step s3 includes following step:
Step s301: first Ramulus et Folium Psychotriae Serpentis, Folium Photiniae (Folium Photiniae serrulatae), Radix Flemingiae Philippinensiss, Radix Achyranthis Bidentatae are added in decocting container and are decocted 10 minutes with small fire；
Step s302: more red, Pterospermi Heterophylli, Fructus Ilicis Cornutae, Radix Salviae Plectranthoidiss, JIZHUASHEN are added in decocting container and decoct 10 with small fire Minute；
Step s303: again Fructus Abeliae biflorae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), redwood, Rhizoma seu Herba Elatostematis stewardii are added in decocting container.
Described step s2 ~ s5 is to decoct for the first time, also includes step s6:
Second decoction is carried out using 0.7 ~ 0.8l clear water or pure water repeat step s3 ~ s5；
Carry out third time using 0.5 ~ 0.6l clear water or pure water repeat step s3 ~ s5 to decoct.
Described first time decocts and carries out two hours, decocts for second and carries out one hour, and third time decocts and carries out one hour.
Described decocting container is marmite, enamel ware or rustless steel, avoids and uses ironware.
A kind of crude drug pharmacology for treating osteoporotic Chinese medicine composition of the present invention:
Ramulus et Folium Psychotriae Serpentis: bitter in the mouth, cold nature.Thoughts of returning home warp, Liver Channel, kidney channel.Wind-damp dispelling, strengthening bone and muscle, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia, Laryngopharynx swelling and pain, carbuncle, scabies.
Folium Photiniae (Folium Photiniae serrulatae): mild-natured, acrid in the mouth, hardship.Return liver warp, kidney channel.Wind-damp dispelling, antipruritic, bone and muscle strengthening, liver and kidney tonifying.Belong to medicine for rheumatism Lower classification wind-damp dispelling bone and muscle strengthening medicine.
Radix Flemingiae Philippinensiss: mild-natured, sweet in the mouth, micro-puckery.Return liver warp, kidney channel.Expelling wind and removing dampness, bone and muscle strengthening, promoting blood circulation and detoxication.Belong to and kill wind-dispelling The wind-damp dispelling bone and muscle strengthening medicine of classification under wet medicine.
Radix Achyranthis Bidentatae: mild-natured, bitter in the mouth, acid.Return liver warp, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.Belong to promoting blood circulation The blood-activating and menstruation-regulating medicinal of blood stasis dispelling medicine subordinate classification.
Radix cocculi laurifolii: cold in nature, bitter in the mouth, pungent.Return bladder warp, kidney channel, spleen channel.Expelling wind and removing dampness, dredge the meridian passage, removing toxic substances and promoting subsidence of swelling.Belong to Medicine for rheumatism subordinate classification wind-damp dispelling bone and muscle strengthening medicine.
Pterospermi Heterophylli: sweet in the mouth, warm in nature.Returns spleen warp, Liver Channel.Expelling wind and removing dampness, promoting blood circulation and detumescence.Belong to the wind-dispelling in medicine for rheumatism subordinate Wet cold expelling medicine, cures mainly rheumatic arthralgia, lumbar muscle strain, brothers are tingle powerless, traumatic injury.
Fructus Ilicis Cornutae: bitter, puckery, tepor.Enter liver, kidney two warp.Replenishing YIN and removing heat, bone and muscle strengthening.Invigorating the liver and kidney；Strong muscle is active；Astringent or styptic treatment for spontaneous sweating Lower Jiao.Main not empty low grade fever；Bones and muscles pain；Metrorrhagia；Leukorrhagia；Have loose bowels.
Bombyx mori L.: warm in nature, sweet in the mouth, pungent.Return liver warp, spleen channel, stomach.Expelling wind and removing dampness, regulating the function of the stomach to resolve the turbidity.Belong to medicine for rheumatism subordinate to divide The wind-damp dispelling bone and muscle strengthening medicine of class.
Rhizoma Homalomenae: warm in nature, bitter in the mouth, pungent.Return liver warp, kidney channel.Wind-damp dispelling, muscle reinforcing and bone strengthening.Belong to dispelling of medicine for rheumatism subordinate classification Rheumatism bone and muscle strengthening medicine.
Herba Aristolochiae Mollissimae: mild-natured, acrid in the mouth, hardship.Return liver warp, stomach.Dispelling wind and removing obstruction in the collateral, promoting the circulation of QI to relieve pain.Belong under medicine for rheumatism classification Wind-damp dispelling bone and muscle strengthening medicine.
Rhizoma Cibotii: warm in nature, bitter in the mouth, sweet.Return liver warp, kidney channel.Invigorating the liver and kidney, strong waist and knee, wind-damp dispelling.Belong to medicine for rheumatism subordinate classification Wind-damp dispelling bone and muscle strengthening medicine.
Redwood: warm in nature, mildly bitter flavor.Expelling wind and removing dampness, promoting flow of QI and blood, subduing swelling and detoxicating.Dispelling the wind and dampness pathogens arthralgia pain, Peptic Ulcerss, traumatic injury Damage, carbuncle.
Rhizoma seu Herba Elatostematis stewardii: root sweet in the mouth, mild-natured.Stem and leaf sweet in the mouth, slight bitter, mild-natured.Return liver warp.Root wind-dispelling, dampness removing, promoting blood circulation, dissipating blood stasis, only Blood, stem and leaf wind-dispelling, dampness removing, relaxing muscles and tendons, promoting blood circulation, control edema, tinea pedis, jaundice, stranguria with turbid discharge, leukorrhagia, carbuncle, treat poison.
The present invention compared with prior art, has advantages below and a beneficial effect:
The present invention be based on to the understanding of osteoporosis symptoms mechanism and Therapeutic Principle, the method using being directly administered orally, attack benefit and Apply, there is strengthening muscles and bones, the effect for the treatment of rheumatism, evident in efficacy, quality is easily controlled, and good stability has no adverse reaction substantially.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but embodiments of the present invention not limited to this.
Embodiment 1:
One kind is used for treating osteoporotic Chinese medicine formula, including 15 ~ 23 parts of Ramulus et Folium Psychotriae Serpentis by weight, Folium Photiniae (Folium Photiniae serrulatae) 14 ~ 20 Part, 10 ~ 16 parts of Radix Flemingiae Philippinensiss, 16 ~ 24 parts of Radix Achyranthis Bidentatae, 17 ~ 23 parts of Radix cocculi laurifolii, 13 ~ 19 parts of Pterospermi Heterophylli, 18 ~ 24 parts of Fructus Ilicis Cornutae, Bombyx mori L. 16 ~ 22 parts, 10 ~ 16 parts of Rhizoma Homalomenae, 12 ~ 20 parts of Herba Aristolochiae Mollissimae, 15 ~ 23 parts of Rhizoma Cibotii, 12 ~ 20 parts of redwood, 15 ~ 19 parts of Rhizoma seu Herba Elatostematis stewardii.
The method of the present embodiment medicine preparation, including following step:
Step s1: in parts by weight, weigh 15 ~ 23 parts of Ramulus et Folium Psychotriae Serpentis, 14 ~ 20 parts of Folium Photiniae (Folium Photiniae serrulatae), 10 ~ 16 parts of Radix Flemingiae Philippinensiss, Radix Achyranthis Bidentatae 16 ~ 24 Part, red 17 ~ 23 parts, 13 ~ 19 parts of Pterospermi Heterophylli, 18 ~ 24 parts of Fructus Ilicis Cornutae, 16 ~ 22 parts of Radix Salviae Plectranthoidiss, 10 ~ 16 parts of JIZHUASHEN, Fructus Abeliae biflorae 12 ~ 20 parts, 15 ~ 23 parts of Crepis crocea Babc.(C.turczaninowii C.A.Mey.), 12 ~ 20 parts of redwood, 15 ~ 19 parts of Rhizoma seu Herba Elatostematis stewardii；
Step s2: above-mentioned whole raw material of Chinese medicine medicines use in advance clear water or pure water to soak 30 minutes, water consumption for immersion is 0.9 ~ 1.1l；
Step s3: the liquid medicine of the raw material of Chinese medicine medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct Carry out two hours, be added in the following order when adding medicine:
Step s301: first Ramulus et Folium Psychotriae Serpentis, Folium Photiniae (Folium Photiniae serrulatae), Radix Flemingiae Philippinensiss, Radix Achyranthis Bidentatae are added in decocting container and are decocted 10 minutes with small fire；
Step s302: more red, Pterospermi Heterophylli, Fructus Ilicis Cornutae, Radix Salviae Plectranthoidiss, JIZHUASHEN are added in decocting container and decoct 10 with small fire Minute；
Step s303: again Fructus Abeliae biflorae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), redwood, Rhizoma seu Herba Elatostematis stewardii are added in decocting container；
Step s4: first make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine ~ 3 times；
Step s5: after the completion of decoction, leach medicinal liquid, obtained medicinal liquid is endo-medicine.
Step s6: second decoction is carried out one hour using 0.7 ~ 0.8l clear water or pure water repeat step s3 ~ s5；
Third time is carried out using 0.5 ~ 0.6l clear water or pure water repeat step s3 ~ s5 and decocts one hour.
Embodiment 2:
Including 15 parts of Ramulus et Folium Psychotriae Serpentis by weight, 14 parts of Folium Photiniae (Folium Photiniae serrulatae), 10 parts of Radix Flemingiae Philippinensiss, 16 parts of Radix Achyranthis Bidentatae, 17 parts of Radix cocculi laurifolii, half maple 13 parts of lotus, 18 parts of Fructus Ilicis Cornutae, 16 parts of Bombyx mori L., 10 parts of Rhizoma Homalomenae, 12 parts of Herba Aristolochiae Mollissimae, 15 parts of Rhizoma Cibotii, 12 parts of redwood, Rhizoma seu Herba Elatostematis stewardii 15 Part.
Embodiment 3:
Including 17 parts of Ramulus et Folium Psychotriae Serpentis by weight, 16 parts of Folium Photiniae (Folium Photiniae serrulatae), 13 parts of Radix Flemingiae Philippinensiss, 19 parts of Radix Achyranthis Bidentatae, 19 parts of Radix cocculi laurifolii, half maple 15 parts of lotus, 21 parts of Fructus Ilicis Cornutae, 18 parts of Bombyx mori L., 13 parts of Rhizoma Homalomenae, 15 parts of Herba Aristolochiae Mollissimae, 18 parts of Rhizoma Cibotii, 17 parts of redwood, Rhizoma seu Herba Elatostematis stewardii 16 Part.
Embodiment 4:
Including 15 parts of Ramulus et Folium Psychotriae Serpentis by weight, 14 parts of Folium Photiniae (Folium Photiniae serrulatae), 13 parts of Radix Flemingiae Philippinensiss, 18 parts of Radix Achyranthis Bidentatae, 23 parts of Radix cocculi laurifolii, half maple 16 parts of lotus, 24 parts of Fructus Ilicis Cornutae, 20 parts of Bombyx mori L., 13 parts of Rhizoma Homalomenae, 20 parts of Herba Aristolochiae Mollissimae, 23 parts of Rhizoma Cibotii, 18 parts of redwood, Rhizoma seu Herba Elatostematis stewardii 18 Part.
Toxicology test:
Acute toxicity test:
Experimental observation, because measuring ld50, therefore has carried out the mensure of maximum dosage-feeding.Chinese medicine compound prepared by embodiment 1 Mixture is dissolved in sterile saline, is configured to solution gavage mice, and result shows, raw with medicine maximum administration concentration 9.65 Medicine/ml, maximum administered volume 50ml/kg was administered twice to mouse stomach in 24 hours, and mice maximum dosage-feeding is 763.25g Crude drug/kg, untoward reaction and death in animal, anatomic observation each internal organs no abnormality seen.
Long term toxicity test:
Sd rat 80 is applied in this test, and Chinese medicine compound mixture prepared by embodiment 1 is dissolved in sterile saline, configuration Become solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage group, continuous gavage is administered 12 weeks, observes in the present invention The impact to animal indices for the drug composition.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to big The body weight of Mus, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. all have no significant effect；Blood biochemical 12 Item index determining result, 12 weeks low dose group bili values of administration are higher than matched group (p < 0.05)；Low dose group, middle dose group tp value Higher than matched group (p < 0.05), but all within normal physiologic range, other indexs compare no significant difference with matched group.Recover Phase each administration group indices measured value compares equal no significant difference with matched group.Each group each internal organs gross examination of skeletal muscle no abnormality seen.
Using medicine of the present invention be directed to various sufferers of osteoporosis face clinical statisticses data:
Through the Clinical practice of 200 patients, wherein male patient 116, female patient 84, medication age object 60 ~ 70 years old.Wherein Minimum 60 years old, maximum 69 years old, 65 years old mean age.
Lee, 66 years old, with osteoporosises, frequent seat began to general aching for a moment, and occurrence number more frequency of fracturing Numerous, using the present invention through four courses for the treatment of, osteoporotic symptom starts to disappear, and the body also more strong many than in the past can Enough carry out INVENTIONConventional exercise.
The above, be only presently preferred embodiments of the present invention, and not the present invention is done with any pro forma restriction, every according to Any simple modification above example made according to the technical spirit of the present invention, equivalent variations, each fall within the protection of the present invention Within the scope of.

Claims (5)

1. one kind be used for treating osteoporotic Chinese medicinal preparation method it is characterised in that: include following step:
Step s1: in parts by weight, weigh 15 ~ 23 parts of Ramulus et Folium Psychotriae Serpentis, 14 ~ 20 parts of Folium Photiniae (Folium Photiniae serrulatae), 10 ~ 16 parts of Radix Flemingiae Philippinensiss, Radix Achyranthis Bidentatae 16 ~ 24 Part, red 17 ~ 23 parts, 13 ~ 19 parts of Pterospermi Heterophylli, 18 ~ 24 parts of Fructus Ilicis Cornutae, 16 ~ 22 parts of Radix Salviae Plectranthoidiss, 10 ~ 16 parts of JIZHUASHEN, Fructus Abeliae biflorae 12 ~ 20 parts, 15 ~ 23 parts of Crepis crocea Babc.(C.turczaninowii C.A.Mey.), 12 ~ 20 parts of redwood, 15 ~ 19 parts of Rhizoma seu Herba Elatostematis stewardii；
Step s2: above-mentioned whole raw material of Chinese medicine medicines use in advance clear water or pure water to soak 30 minutes, water consumption for immersion is 0.9 ~ 1.1l；
Step s3: the liquid medicine of the raw material of Chinese medicine medicine after soaking and its immersion is added in decocting container, adds a cover and jointly decoct；
Step s4: first make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine ~ 3 times；
Step s5: after the completion of decoction, leach medicinal liquid, obtained medicinal liquid is endo-medicine.
2. one kind according to claim 1 be used for treating osteoporotic Chinese medicinal preparation method it is characterised in that: described Step s3 includes following step:
Step s301: first Ramulus et Folium Psychotriae Serpentis, Folium Photiniae (Folium Photiniae serrulatae), Radix Flemingiae Philippinensiss, Radix Achyranthis Bidentatae are added in decocting container and are decocted 10 minutes with small fire；
Step s302: more red, Pterospermi Heterophylli, Fructus Ilicis Cornutae, Radix Salviae Plectranthoidiss, JIZHUASHEN are added in decocting container and decoct 10 with small fire Minute；
Step s303: again Fructus Abeliae biflorae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), redwood, Rhizoma seu Herba Elatostematis stewardii are added in decocting container.
3. one kind according to claim 1 be used for treating osteoporotic Chinese medicinal preparation method it is characterised in that: described Step s2 ~ s5 is to decoct for the first time, also includes step s6:
Second decoction is carried out using 0.7 ~ 0.8l clear water or pure water repeat step s3 ~ s5；
Carry out third time using 0.5 ~ 0.6l clear water or pure water repeat step s3 ~ s5 to decoct.
4. one kind according to claim 3 be used for treating osteoporotic Chinese medicinal preparation method it is characterised in that: described Decoct for the first time and carry out two hours, decoct for second and carry out one hour, third time decocts and carries out one hour.
5. one kind according to claim 1 be used for treating osteoporotic Chinese medicinal preparation method it is characterised in that: described Decocting container is marmite, enamel ware or rustless steel, avoids and uses ironware.
CN201610975262.9A 2016-11-07 2016-11-07 Preparation method of traditional Chinese medicine for treating osteoporosis Withdrawn CN106361947A (en)

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CN107468834A (en) * 2017-08-29 2017-12-15 成都泠汐尚品科技有限公司 A kind of Chinese medicinal preparation method for being advantageous to strengthen muscles and bones and remove obstruction in channels to relieve pain
CN107519340A (en) * 2017-08-29 2017-12-29 成都泠汐尚品科技有限公司 A kind of Chinese medicinal preparation method that can treat osteoporosis enhancing bone absorption
CN107582769A (en) * 2017-08-29 2018-01-16 成都泠汐尚品科技有限公司 A kind of Chinese medicine preparation that can treat osteoporosis enhancing bone absorption

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CN107468834A (en) * 2017-08-29 2017-12-15 成都泠汐尚品科技有限公司 A kind of Chinese medicinal preparation method for being advantageous to strengthen muscles and bones and remove obstruction in channels to relieve pain
CN107519340A (en) * 2017-08-29 2017-12-29 成都泠汐尚品科技有限公司 A kind of Chinese medicinal preparation method that can treat osteoporosis enhancing bone absorption
CN107582769A (en) * 2017-08-29 2018-01-16 成都泠汐尚品科技有限公司 A kind of Chinese medicine preparation that can treat osteoporosis enhancing bone absorption

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