CN103191315B - Traditional Chinese medicine for treating postmenopausal osteoporosis - Google Patents
Traditional Chinese medicine for treating postmenopausal osteoporosis Download PDFInfo
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- CN103191315B CN103191315B CN201310147723.XA CN201310147723A CN103191315B CN 103191315 B CN103191315 B CN 103191315B CN 201310147723 A CN201310147723 A CN 201310147723A CN 103191315 B CN103191315 B CN 103191315B
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine for treating postmenopausal osteoporosis. The traditional Chinese medicine is prepared from prepared rehmannia, rhizoma cibotii, herba epimedii, fructus psoraleae, oyster, yam, prepared fleece-flower root, eucommia bark, gastrodia elata, medlar, dogwood fruit pulp, radix achyranthis bidentatae, codonopsis pilosula, donkey-hide gelatin, black sesame, parasitic loranthus, glossy privet and schisandra chinensis. The traditional Chinese medicine is in accordance with the theory of traditional Chinese medicinal differentiation, and is combined with the fact that the occurrence of postmenopausal osteoporosis is related to kidney deficiency and spleen deficiency, wherein kidney deficiency is a main pathogenesis of postmenopausal osteoporosis. From the view of traditional Chinese medicine, kidney governs bones and belongs to water in five elements, liver governs tendons and belongs to wood in five elements, so that deficiency of spleen and kidney means the loss of water and wood, which causes that wood is nourished; and tendons and bones are not tonified to cause postmenopausal osteoporosis with the passing of time. Thus, postmenopausal osteoporosis is treated by tonifying spleen and nourishing liver kidney to achieve the fundamental treatment effects of treating both principal and secondary aspect of disease, and preventing relapse.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicine for the treatment of postmenopausal osteoporosis.
Background technology
Postmenopausal osteoporosis is to take that bone amount reduces and osseous tissue microstructure degenerative change is feature, and bone fragility increases, be easy to occur a kind of general metabolic bone disease of fracturing.Women after menopause due to the decline of hormonal readiness, the deficiency of calcium and vitamin D intake, the sickness rate of osteoporosis is higher.That main manifestations is that stature becomes is short or bow-backed, lumbar and back pain, easily fracture etc. occurs, have a strong impact on the life quality of middle aged and aged women, it all easily fractures in microtrauma or atraumatic situation, to patient, bring great misery and high medical expense, the quality of life that has had a strong impact on patient's old age, Ye Gei family and society bring white elephant.Consult domestic and foreign literature and find, at present the treatment of this disease is lacked to medicine safely and effectively.The mode of normal adopt hormone, replenishing the calcium, take vitamin, moderate exercise is treated, and effect is not ideal enough, and side effect greatly, easily recurrence, the Chinese herbal medicine of some treatment primary disease, does not have the effect for the treatment of.
Summary of the invention
The object of this invention is to provide and a kind ofly can effect a radical cure postmenopausal osteoporosis and instant effect, short treating period, Chinese medicine that cure rate is high.
For realizing object of the present invention, existing according to following technical scheme.This medicine is to be made by the raw material of following weight portion proportioning:
Radix Rehmanniae Preparata 25-40 part, Rhizoma Cibotii 15-30 part, Herba Epimedii 15-20 part, Fructus Psoraleae 16-25 part, Concha Ostreae 12-20 part, Rhizoma Dioscoreae 25-30 part, Radix Polygoni Multiflori Preparata 10-20 part, Cortex Eucommiae 12-25 part, Rhizoma Gastrodiae 8-15 part, Fructus Lycii 8-15 part, Fructus Corni 8-15 part, Radix Achyranthis Bidentatae 15-30 part, Radix Codonopsis 15-30 part, Colla Corii Asini 10-15 part, Semen Sesami Nigrum 15-20 part, Herba Taxilli 15-30 part,, Fructus Ligustri Lucidi 12-17 part, Fructus Schisandrae Chinensis 8-15 part.
Medicine of the present invention is according to the theory of Chinese medical discrimination, in conjunction with the generation of primary disease mainly with suffer from a deficiency of the kidney, insufficiency of the spleen relevant, wherein suffering from a deficiency of the kidney is the Etiological of primary disease.In Chinese medicine, kidney governing bones, the main water of the five elements, liver governing tendons, the five elements belong to wood, the loss of spleen, kidney, the disappearance of water, soil, causes wood not conserve, and muscles and bones mistake is supported, and with the passing of time brings out primary disease.Therefore, treatment primary disease is worked as with spleen invigorating, and the rule for the treatment of of nourishing the liver and kidney just can be received the radical cure effect for the treatment of both the principal and secondary aspects of a disease, difficult recurrence.
Side separates:
Radix Rehmanniae Preparata: enrich blood moist; Benefit essence is filled out marrow, cures mainly blood deficiency and yellow complexion; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees.
Rhizoma Cibotii: wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.Invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint.Control back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, loses and drowns, frequent micturition, seminal emission, leucorrhea.
Herba Epimedii: taste is returned through acrid, sweet, warm.Return liver, kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Cure mainly impotence and seminal emission; Cold caused by deficiency is sterile; Frequent micturition incontinence; Dyspnea and cough due to deficiency of the kidney; Soreness of the waist and knees; Rheumatic arthralgia; Hemiplegia; Extremity are meciless.
Fructus Psoraleae: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis.
Concha Ostreae: medicine for calming liver and calming endopathic wind; Yin-nourishing drug.There are convergence, calmness, removing toxic substances, analgesic effect.Modern study, Concha Ostreae contains 80%～95% calcium carbonate, calcium phosphate and calcium sulfate, and containing magnesium, aluminum, silicon and ferrum oxide etc., its a lot of dosage forms are used for the treatment of the patient of osteoporosis and other calcium deficiency clinically.
Rhizoma Dioscoreae: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Radix Polygoni Multiflori Preparata: invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening, changes turbid blood fat reducing.For blood deficiency and yellow complexion, dizzy ear toot, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, hyperlipemia.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, there is rubbish in the body of removing, strengthen human body cell substance metabolism, prevent that muscle skeleton is aging, balance human blood-pressure, decomposer inner cholesterol, reduces body fat, recover blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system, improve white blood cell count, strengthen the remarkable efficacy such as body immunity.
Rhizoma Gastrodiae: sweet flat, return Liver Channel, effect endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
Fructus Lycii: nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual unclear; Soreness of the waist and knees; Impotence and seminal emission; Cough due to consumptive disease; The taking fluids profusely of quenching one's thirst.
Fructus Corni: liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping and only collapse hidroschesis and also have in addition promoting the production of body fluid to quench thirst.Be used for soreness of waist and knee joint dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition.
Radix Achyranthis Bidentatae: invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome.
Radix Codonopsis: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Colla Corii Asini: the YIN nourishing of enriching blood, moisturize hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, dysphoria and insomnia, xeropulmonary cough
Semen Sesami Nigrum: invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
Herba Taxilli: invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Hypertension.
Fructus Ligustri Lucidi: liver and kidney tonifying; Crow must improving eyesight.
Fructus Schisandrae Chinensis: astringe the lung, nourishing kidney, promotes the production of body fluid, receives antiperspirant, arresting seminal emission.
The inventor thinks, postmenopausal osteoporosis is clinical modal primary osteoporosis, and its pathogeny is postmenopausal estrogen hyposecretion, the effect reduction that makes it promote calcitonin secretion and suppress osteoclast stimulating osteoblast, osteoclast is too active, bone conversion increases, and bone formation and bone resorption increase, and bone resorption is greater than bone formation, affect maturation and the bone mineralising of ossein, UCaE increases, and intestinal calcium absorption declines, and causes osteoporosis.Apply clinically estrogen effect aspect control postmenopausal osteoporosis remarkable, but at present conventional natural estrogen or the derivant of semi-synthetic estrogen all there is certain side effect, should not apply for a long time.Therefore, can prolonged application, little, the good Therapeutic Method of curative effect of side effect becomes the focus that people inquire into.
Epidemiological study has also confirmed that the bone mineral content of Patients with Kidney Deficiency Type is not only lower than Healthy People of the same age, and lower than the non-patient who suffers from a deficiency of the kidney.Therefore, insufficiency of the spleen, to suffer from a deficiency of the kidney be the basic reason that osteoporosis occurs.Experiment shows, the effect that strengthening spleen, tonifying kidney Chinese medicine has promoting bone growing and suppresses bone resorption, reduces bone turnover rate, improves bone mass.In side, all medicines share, both can tonifying kidney-yin, and benefiting essence-blood, the kidney warming sun, bone and muscle strengthening, suppresses differentiation of osteoclast, promoting bone growing; Again can spleen invigorating to mend the day after tomorrow, intestinal calcium absorption is increased, UCaE reduces, and prevents and treats osteoporosis.All medicines share, and can increase bone density, and promoting bone growing suppresses bone resorption, increases intestinal calcium absorption, improves symptom, evident in efficacy.This research shows, the present invention treats postmenopausal osteoporosis and is obviously better than Western medicine curative effect.
The specific embodiment:
In following ratio, take raw material
Radix Rehmanniae Preparata 25-40 part, Rhizoma Cibotii 15-30 part, Herba Epimedii 15-20 part, Fructus Psoraleae 16-25 part, Concha Ostreae 12-20 part, Rhizoma Dioscoreae 25-30 part, Radix Polygoni Multiflori Preparata 10-20 part, Cortex Eucommiae 12-25 part, Rhizoma Gastrodiae 8-15 part, Fructus Lycii 8-15 part, Fructus Corni 8-15 part, Radix Achyranthis Bidentatae 15-30 part, Radix Codonopsis 15-30 part, Colla Corii Asini 10-15 part, Semen Sesami Nigrum 15-20 part, Herba Taxilli 15-30 part, Fructus Ligustri Lucidi 12-17 part, Fructus Schisandrae Chinensis 8-15 part.
Preparation method of the present invention is as follows:
1), by prescription proportioning, take above-mentioned medical material standby;
2), the pulverizing medicinal materials taking to 120 mesh sieves excessively, mix homogeneously, then flashing is ball, obtains Chinese medicine of the present invention.
Instructions of taking: every day 3 times, one after each meal, each 6 grams, warm water delivery service.General 30 days courses for the treatment of.
For showing the therapeutic effect of Chinese medicine of the present invention to postmenopausal osteoporosis, the inventor has carried out clinical observation to 200 routine cases, and existing report is as follows.
1. data and method
1.1 physical data all patients with reference in January, 1999 China osteoporosis associations according to the growth and development characteristics of Chinese's skeleton and large sample bone densitometry result, formulation be suitable for Chinese unified diagnostic criteria.The bone density (BMD) of take is less than M (peak bone density), and to deduct 2 standard deviations be osteoporosis.
Collect altogether case 200 examples, age age >=45 year old, 1 year above women of menopause, (2) application dual intensity X bone density meter checks, other youngster of proximal femur BMD and the same sex is compared minimizing >=25%; (3) clinical cardinal symptom is spontaneous lumbago and backache and (or) heavy burden pain, and minor symptom is coldness of the body with chills or feverish sensation in the palms and soles, soreness of the waist and knees, and tinnitus, indigestion and loss of appetite, abdominal distention, large dry stool or diarrhea with loose stool, frequent micturition, frequent urination at night, light red tongue, tongue are white, CHI-pulse being weak.Get rid of and to suffer from the Other diseases that can affect bone biochemical markers, or took and can affect the medicine of bone metabolism person, or be associated with the serious primary disease such as cardiovascular, liver, kidney and blood system and psychotic.Be divided at random 2 groups, treatment group 100 examples; Matched group 100 examples.At aspects such as sex, age, the course of disease, the state of an illness, learn by statistics processing for 2 groups, no statistical significance, has comparability (P > 0.01).
Before and after treatment, carry out respectively the mensuration of main pain symptom scoring and bone density (BMD), Bone Gla protein (BGP), urine pyridol (PYD).
Two, Therapeutic Method
Treatment group: oral Chinese medicine of the present invention, days 3 times, each 6 grams, warm water delivery service after meal.
Matched group: oral Caltrate D tablet, (Jiangsu Wyeth Wyeth pharmaceuticals produces, every 600mg), each 1, every day 2 times; Vitamin D3 500U, every day 2 times is oral.
All take 30 as 1 course for the treatment of, observe 1～6 course for the treatment of for above 2 groups.
2.1 result treatment group total effective rates 97.0%, 84.0%, 2 group of matched group total effective rate relatively has statistical significance (P < 0.01).Treatment group is better than matched group (P < 0.01).This invention has that innovation is advanced, method is simple, convenient and practical, safe and reliable, be easy to the features such as popularizations, so has higher clinic popularization and application values, has good Social benefit and economic benefit.
Before and after two groups of patient treatments, curative effect compares in Table 2.1,
Table 2.1 liang group patient curative effect comparison
Note: two groups of curative effect comparisons, difference has statistical significance (P < 0.01)
Three, with domestic and international similar technology comparison
The present invention relatively has following features with current domestic and international similar technology:
(1) systematicness: problem is from clinical symptoms, pathogenesis, and the mechanism of action of the present invention etc. are inquired into, so comprehensively clinical research, at present domestic and international less report.
(2) practicality: this problem is clinical research, therefore selected index is close to clinically, even observation index is also commonly used by clinical, and cogency is strong, easy operating, this promise the clinical practice using value of this research.
(3) objectivity: in problem, most observation index are objective indicator as bone density, Bone Gla protein, urine pyridol etc., and this point is strengthened the reliability of result of study, stability.
(4) advanced, novelty: use Chinese patent drugs for treatment primary osteoporosis, and combine with objective determination index, patient is detected for inquiring into postmenopausal osteoporosis pathogeny, the at present domestic and international less report of seeing.
Top standard based on above several aspect the present invention in domestic similar research.
Claims (1)
1. treat a Chinese medicine for postmenopausal osteoporosis, it is characterized in that it is to be made by the raw material of following weight portion proportioning: Radix Rehmanniae Preparata 25-40 part, Rhizoma Cibotii 15-30 part, Herba Epimedii 15-20 part, Fructus Psoraleae 16-25 part, Concha Ostreae 12-20 part, Rhizoma Dioscoreae 25-30 part, Radix Polygoni Multiflori Preparata 10-20 part, Cortex Eucommiae 12-25 part, Rhizoma Gastrodiae 8-15 part, Fructus Lycii 8-15 part, Fructus Corni 8-15 part, Radix Achyranthis Bidentatae 15-30 part, Radix Codonopsis 15-30 part, Colla Corii Asini 10-15 part, Semen Sesami Nigrum 15-20 part, Herba Taxilli 15-30 part, Fructus Ligustri Lucidi 12-17 part, Fructus Schisandrae Chinensis 8-15 part.
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| CN103599327A (en) * | 2013-11-11 | 2014-02-26 | 漯河医学高等专科学校 | Method for preventing and treating primary osteoporosis by using self-made bone strengthening osteoporosis solidifying drink |
| CN104644732B (en) * | 2015-03-10 | 2016-04-27 | 吴建国 | A kind of Chinese medicine preparation for the treatment of deficiency of the liver and kindey type postmenopausal osteoporosis |
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Patent Citations (4)
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| CN101053608A (en) * | 2006-04-12 | 2007-10-17 | 杨义澄 | 'Gushukang' micropills and its preparation technology |
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