CN106362066A - Medicinal liquor for treatment of rheumatic and rheumatoid diseases and preparation method thereof - Google Patents

Medicinal liquor for treatment of rheumatic and rheumatoid diseases and preparation method thereof Download PDF

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CN106362066A
CN106362066A CN201610960525.9A CN201610960525A CN106362066A CN 106362066 A CN106362066 A CN 106362066A CN 201610960525 A CN201610960525 A CN 201610960525A CN 106362066 A CN106362066 A CN 106362066A
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parts
radix
rheumatic
treatment
medicinal liquor
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刘江
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a medicinal liquor for treatment of rheumatic and rheumatoid diseases and a preparation method thereof. The medicinal liquor comprises, by weight, 45-55 parts of rhizoma fagopyri cymosi, 90-100 parts of radix achyranthis bidentatae, 30-40 parts of radix polygoni multiflori, 8-12 parts of tuckahoe, 90-110 parts of polygonum cuspidatum, 14-16 parts of lilium brownii, 30-40 parts of fructus alpiniae oxyphyllae, 10-20 parts of angelica sinensis, 20-30 parts of radix dipsaci, 8-15 parts of cortex eucommiae, 90-110 parts of Fructus Lycii, 30-40 parts of semen euryales, 90-110 parts of fructus jujubae, 30-40 parts of herba portulacae, 45-55 parts of chinaroot greenbrier, 4-6 parts of cortex acanthopanacis, 90-110 parts of caulis spatholobi, 30-40 parts of henry currant root, 10-15 parts of rhizome of rehmannia, 10-15 parts of radix notoginseng. The medicinal liquor is suitable for the treatment of cervical spondylosis, periarthritis of shoulder, intervertebral disc herniation, lumbar muscle strain, arthritis and other common rheumatic and rheumatoid diseases, and effective in treatment. Long term intake of the medicinal liquor has no apparent side effects. The medicinal liquor can improve the patient's work and life quality, and the medicinal liquor is worthy to be promoted and popularized.

Description

A kind of treat medicated wine of rheumatic and rheumatoid disease and preparation method thereof
Technical field
The present invention relates to medicated wine technical field is and in particular to a kind of medicated wine treating rheumatic and rheumatoid disease and its preparation Method.
Background technology
Rheumatic and rheumatoid diseases belong to common clinical, frequently-occurring disease, have " stupid ", " difficult ", " being tired of ", obstinate, repeatedly The feature of outbreak, cardinal symptom show as muscle, joint, muscles and bones etc. pain, miserable, weigh, numb, joint stuffiness, or Arthroncuss, are one of persistent ailments of serious harm human health, sickness rate rises year by year in recent years, disability rate also rises year by year, Have a strong impact on work and the quality of life of patient.Common rheumatic and rheumatoid diseases have scapulohumeral periarthritis, cervical spondylosiss, sciatica, Fibromyalgia, osteoporosis (gout, migrans pain) are struvite, intervertebral disk hernia, lumbar muscle strain, bone joint pain, pass The diseases such as section surrounding soft tissue (including flesh, tendon, ligament).
Think in Chinese medicine that rheumatic and rheumatoid disease is mainly caused by intrusion of pathogenic wind-cold-dampness, belong to the model of Chinese medical ' arthralgia syndrome ' Farmland.When human autoimmune is low, wet three gas cuts of wind and cold enter skin, so that QI-blood circulation is obstructed, blockage of meridian is obstructed, thus outward Showing as various types of pain.Treatment to this kind of disease mainly has non-operative treatment and operative therapy two species at present Type.Non-operative treatment mainly adopts acupuncture, massage, physical therapy, traction, injection treatment, oral nonsteroidal antiinflammatory drug etc..Operation is treated Rule is by analgesia, eliminates and stimulates, and promotes stable, prevents the principle of progressive injury from carrying out, but operative therapy Middle complication is more with contraindication, dangerous high, painful big, is just to select in the case that other therapies are all invalid.And non- In operative therapy, by the Western medicine of the substantial amounts of antibiotic of long-term taking and hormoness, easily make the vital organs of the human body of most of patients impaired And cause other pathological changes, gastrointestinal function disorder, nervous system disorders etc., and treatment cost is high, curative effect is not notable, easily recurs； The physical therapy methods such as traction easily make cervical region multi-joint network ligament elongate and bring injury.
Chinese medicine in rheumatic and rheumatoid disease medication market share critical role because Chinese medicine Small side effects, curative effect Definite it is adaptable to long-term prescription.Therefore, according to the characteristic of Chinese medicine develop a kind of effective and confirmed by most people right There is good using value in the medicated wine that treatment rheumatic and rheumatoid disease has good result.
Content of the invention
For the deficiencies in the prior art, the invention provides a kind for the treatment of rheumatism and rheumatoid disease safe, evident in efficacy Medicated wine of disease and preparation method thereof.
For realizing object above, the present invention is achieved by the following technical programs:
A kind of medicated wine treating rheumatic and rheumatoid disease, is made up of the raw material of following weight portion: Rhizoma Fagopyri Dibotryiss 45-55 part, Radix Achyranthis Bidentatae 90-110 part, Radix Polygoni Multiflori 30-40 part, Poria 8-12 part, Rhizoma Polygoni Cuspidati 90-110 part, Bulbus Lilii 14-16 part, Fructus Alpiniae Oxyphyllae 30-40 Part, Radix Angelicae Sinensis 10-20 part, Radix Dipsaci 20-30 part, Cortex Eucommiae 8-15 part, Fructus Lycii 90-110 part, Semen Euryaless 30-40 part, Fructus Jujubae 90-110 Part, Herba Portulacae 30-40 part, Rhizoma Smilacis Chinensiss 45-55 part, Cortex Acanthopanciss 4-6 part, Caulis Spatholobi 90-110 part, Sabia schumanniana Diels 30-40 part, Radix Rehmanniae Preparata 10- 15 parts, Radix Notoginseng 10-15 part.
Preferably, it is made up of the raw material of following weight portion: 50 parts of Rhizoma Fagopyri Dibotryiss, 100 parts of Radix Achyranthis Bidentatae, 35 parts of Radix Polygoni Multiflori, Poria 10 parts, 100 parts of Rhizoma Polygoni Cuspidati, 15 parts of Bulbus Lilii, 35 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Radix Angelicae Sinensis, 25 parts of Radix Dipsaci, 10 parts of the Cortex Eucommiae, 100 parts of Fructus Lycii, Gorgon euryale 35 parts of reality, 100 parts of Fructus Jujubae, 35 parts of Herba Portulacae, 50 parts of Rhizoma Smilacis Chinensiss, 5 parts of Cortex Acanthopanciss, 100 parts of Caulis Spatholobi, 35 parts of Sabia schumanniana Diels, Radix Rehmanniae Preparata 10- 15 parts, Radix Notoginseng 10-15 part.
The preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease, step is as follows: weighs each raw material in proportion, cleaning is dry Only, pulverize, mix homogeneously, insert in container, add the airtight immersion of Chinese liquor 50 days, stir 1 time within every 7 days, take supernatant, squeeze medicine Slag, filters, press liquor is merged with supernatant, filling and sealing is standby.
Preferably, the number of degrees of described Chinese liquor are 38 ° -52 °.
Preferably, described Chinese liquor consumption is 16-20 times of medical material.
In the present invention, effect of each raw material Chinese medicine is as follows:
Rhizoma Fagopyri Dibotryiss: sour in the mouth, hardship, cool in nature, return lung, liver, spleen, stomach, large intestine channel, have functions that internal heat anticance, detumescence hold back blood, Its decoct has antiinflammatory action, and contained glycoside plays the role of to accelerate blood coagulation, in vitro to staphylococcus aureuses, pneumonia ball Bacterium, dysentery bacterium, escherichia coli, bacillus pyocyaneus all have bacteriostasis.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, mild-natured, enter the heart, liver, large intestine channel, there is promoting blood circulation to remove blood stasis, damp eliminating diuresis, the work(of heat-clearing and toxic substances removing Effect, modern pharmacological research shows, the ecdysterone contained by Radix Achyranthis Bidentatae can improve liver function, reduces plasma cholesterol, has enhancing thin The effect of cytoactive, has obvious enhancing body fluid immunity function rich in Inokopolyose, also has antiinflammatory and analgesic activity.
Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery, slightly warm in nature, enter spleen, lung, kidney three warp, there is nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel Wind, effect of removing toxic substances.
Poria: sweet in the mouth, light, mild-natured, GUIXIN, lung, spleen, kidney channel, there are promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of mind calming.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, Return liver, gallbladder, lung meridian, there is removing dampness through diuresis and removing jaundice, heat-clearing and toxic substances removing, eliminating stasis to stop pain, cough-relieving Effect of expectorant, can be used for jaundice due to damp-heat, rheumatic arthralgia, carbuncle sore tumefacting virus, the disease such as lump in the abdomen.
Bulbus Lilii: sweet in the mouth, cold in nature, GUIXIN, lung meridian, there is nourishing YIN and moistening the lung, effect of clearing away heart-fire for tranquillization.
Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature, enter the heart, spleen, kidney channel, there is the kidney warming astringent sperm contracting urine, the effect of saliva is taken the photograph in warming the spleen appetizing.
Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature, Return liver, the heart, spleen channel, there are replenishing and activating blood, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.
Radix Dipsaci: slightly warm in nature, bitter in the mouth, pungent, return liver and kidney channel, have functions that invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia, use In diseases such as treatment deficiency of the liver and kindey, soreness of the waist and knees, rheumatic arthralgia, injury of tendon and muscle fracture, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.
The Cortex Eucommiae: sweet in the mouth, warm in nature, return liver and kidney channel, there is invigorating the liver and kidney, control spinal column ache, foot and knee flaccidity, dribbling urination, under the moon Pruritus due to damp pathogen, hypertension, antiabortive effect, to immune system, hormonal system, central nervous system, blood circulation and urinary system There is different degrees of adjustment effect.
Fructus Lycii: sweet in the mouth, mild-natured, return liver and kidney channel, there is nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight, can enhancing body non- Specific immunity acts on.
Semen Euryaless: sweet in the mouth, puckery, mild-natured, returns spleen, kidney channel, there is supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, effect of eliminating dampness and arresting leucorrhea.
Fructus Jujubae: sweet in the mouth, warm in nature, returns spleen, stomach, there is invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, relax the function of the property of medicine.Modern medicine Reason research finds, Fructus Jujubae can make oxygen content in blood strengthen, nourish systemic cell, is the analeptic that a kind of drug effect relaxes.
Herba Portulacae: sour in the mouth, cold in nature, Return liver, large intestine channel, there is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of dysentery relieving.
Rhizoma Smilacis Chinensiss: sweet in the mouth, slight bitter, puckery, mild-natured, return liver and kidney channel, there is dampness removing and remove turbid, wind expelling stagnation removing, the work(of removing toxic substances dissipating blood stasis Effect.
Cortex Acanthopanciss: acrid in the mouth, hardship, warm in nature, return liver and kidney channel, have wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, the work of inducing diuresis to remove edema With.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, return liver and kidney channel, have blood circulation promoting and enriching, menstruction regulating and pain relieving, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, be used for Menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.
Radix Fissistigmatis Oldhamii: taste micro-pungent, mild-natured, Return liver, stomach, there are expelling wind and removing dampness, the effect of promoting blood circulation and stopping pain, main air pain of dampness syndrome, waist Bitterly, have a stomachache, traumatic injury.
Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, return liver warp, kidney channel, there is YIN nourishing of enriching blood, beneficial essence fills out effect of marrow.
Radix Notoginseng: sweet in the mouth, slight bitter, warm in nature, Return liver, stomach, there is dissipate stasis of blood hemostasis, subduing swelling and relieving pain, have heart tonifying, fall Pressure, the immunologic function that can strengthen, liver function protecting, antitumor, antiinflammatory, Auto-regulator metabolism, promote the effect of growth.
The invention has the advantages that: the dialectical compatibility of each raw material Chinese medicine, mutually auxiliary help in medicated wine of the present invention, have expelling wind and cold, Promoting the flow of QI in the collateral by warming the meridian, promoting blood circulation and stopping pain, dehumidifying exempt from effect of numbness, can blood circulation promoting, strengthening the tendons and bones, enhancing immunity it is adaptable to Treatment cervical spondylosiss, scapulohumeral periarthritis, intervertebral disk hernia, the common rheumatic and rheumatoid disease such as lumbar muscle strain, arthritis, long-term taking is pacified Completely without toxic and side effects, and determined curative effect, improve work and the quality of life of patient, have extensive promotional value.
Specific embodiment
Purpose, technical scheme and advantage for making the embodiment of the present invention are clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described it is clear that described embodiment is the present invention one Divide embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making The every other embodiment being obtained under the premise of creative work, broadly falls into the scope of protection of the invention.
Embodiment 1:
A kind of medicated wine treating rheumatic and rheumatoid disease, is made up of the raw material of following weight portion: 50 parts of Rhizoma Fagopyri Dibotryiss, bosom cattle 100 parts of knee joint, 35 parts of Radix Polygoni Multiflori, 10 parts of Poria, 100 parts of Rhizoma Polygoni Cuspidati, 15 parts of Bulbus Lilii, 35 parts of Fructus Alpiniae Oxyphyllae, 15 parts of Radix Angelicae Sinensis, 25 parts of Radix Dipsaci, 10 parts of the Cortex Eucommiae, 100 parts of Fructus Lycii, 35 parts of Semen Euryaless, 100 parts of Fructus Jujubae, 35 parts of Herba Portulacae, 50 parts of Rhizoma Smilacis Chinensiss, 5 parts of Cortex Acanthopanciss, Caulis Spatholobi 100 parts, 35 parts of Sabia schumanniana Diels, 12 parts of Radix Rehmanniae Preparata, 12 parts of Radix Notoginseng.
The preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease, step is as follows: weighs each raw material in proportion, cleaning is dry Only, pulverize, mix homogeneously, insert in container, add 42 ° of airtight immersions of Chinese liquor 50 days, quality of white spirit is 20 times of quality of medicinal material, Stir 1 time within every 7 days, take supernatant, squeeze medicinal residues, filter, press liquor is merged with supernatant, filling and sealing is standby.
Embodiment 2:
A kind of medicated wine treating rheumatic and rheumatoid disease, is made up of the raw material of following weight portion: 47 parts of Rhizoma Fagopyri Dibotryiss, bosom cattle 95 parts of knee joint, 32 parts of Radix Polygoni Multiflori, 10 parts of Poria, 95 parts of Rhizoma Polygoni Cuspidati, 14 parts of Bulbus Lilii, 34 parts of Fructus Alpiniae Oxyphyllae, 14 parts of Radix Angelicae Sinensis, 26 parts of Radix Dipsaci, Du Secondary 8 parts, 90 parts of Fructus Lycii, 32 parts of Semen Euryaless, 98 parts of Fructus Jujubae, 32 parts of Herba Portulacae, 48 parts of Rhizoma Smilacis Chinensiss, 4 parts of Cortex Acanthopanciss, 95 parts of Caulis Spatholobi, 36 parts of Sabia schumanniana Diels, 13 parts of Radix Rehmanniae Preparata, 13 parts of Radix Notoginseng.
The preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease, step is as follows: weighs each raw material in proportion, cleaning is dry Only, pulverize, mix homogeneously, insert in container, add 52 ° of airtight immersions of Chinese liquor 50 days, quality of white spirit is 18 times of quality of medicinal material, Stir 1 time within every 7 days, take supernatant, squeeze medicinal residues, filter, press liquor is merged with supernatant, filling and sealing is standby.
Embodiment 3:
A kind of medicated wine treating rheumatic and rheumatoid disease, is made up of the raw material of following weight portion: 52 parts of Rhizoma Fagopyri Dibotryiss, bosom cattle 105 parts of knee joint, 38 parts of Radix Polygoni Multiflori, 12 parts of Poria, 105 parts of Rhizoma Polygoni Cuspidati, 15 parts of Bulbus Lilii, 40 parts of Fructus Alpiniae Oxyphyllae, 16 parts of Radix Angelicae Sinensis, 26 parts of Radix Dipsaci, 12 parts of the Cortex Eucommiae, 100 parts of Fructus Lycii, 36 parts of Semen Euryaless, 110 parts of Fructus Jujubae, 35 parts of Herba Portulacae, 47 parts of Rhizoma Smilacis Chinensiss, 6 parts of Cortex Acanthopanciss, Caulis Spatholobi 102 parts, 38 parts of Sabia schumanniana Diels, 12 parts of Radix Rehmanniae Preparata, 15 parts of Radix Notoginseng.
The preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease, step is as follows: weighs each raw material in proportion, cleaning is dry Only, pulverize, mix homogeneously, insert in container, add 52 ° of airtight immersions of Chinese liquor 50 days, quality of white spirit is 20 times of quality of medicinal material, Stir 1 time within every 7 days, take supernatant, squeeze medicinal residues, filter, press liquor is merged with supernatant, filling and sealing is standby.
Embodiment 4:
A kind of medicated wine treating rheumatic and rheumatoid disease, is made up of the raw material of following weight portion: 45 parts of Rhizoma Fagopyri Dibotryiss, bosom cattle 110 parts of knee joint, 30 parts of Radix Polygoni Multiflori, 12 parts of Poria, 90 parts of Rhizoma Polygoni Cuspidati, 16 parts of Bulbus Lilii, 30 parts of Fructus Alpiniae Oxyphyllae, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Dipsaci, Du Secondary 15 parts, 90 parts of Fructus Lycii, 40 parts of Semen Euryaless, 90 parts of Fructus Jujubae, 40 parts of Herba Portulacae, 45 parts of Rhizoma Smilacis Chinensiss, 6 parts of Cortex Acanthopanciss, 90 parts of Caulis Spatholobi, 40 parts of Sabia schumanniana Diels, 10 parts of Radix Rehmanniae Preparata, 15 parts of Radix Notoginseng.
The preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease, step is as follows: weighs each raw material in proportion, cleaning is dry Only, pulverize, mix homogeneously, insert in container, add 38 ° of airtight immersions of Chinese liquor 50 days, quality of white spirit is 16 times of quality of medicinal material, Stir 1 time within every 7 days, take supernatant, squeeze medicinal residues, filter, press liquor is merged with supernatant, filling and sealing is standby.
Embodiment 5:
A kind of medicated wine treating rheumatic and rheumatoid disease, is made up of the raw material of following weight portion: 55 parts of Rhizoma Fagopyri Dibotryiss, bosom cattle 90 parts of knee joint, 40 parts of Radix Polygoni Multiflori, 8 parts of Poria, 110 parts of Rhizoma Polygoni Cuspidati, 14 parts of Bulbus Lilii, 40 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Radix Angelicae Sinensis, 30 parts of Radix Dipsaci, Du Secondary 8 parts, 110 parts of Fructus Lycii, 30 parts of Semen Euryaless, 110 parts of Fructus Jujubae, 30 parts of Herba Portulacae, 55 parts of Rhizoma Smilacis Chinensiss, 4 parts of Cortex Acanthopanciss, Caulis Spatholobi 110 Part, 30 parts of Sabia schumanniana Diels, 15 parts of Radix Rehmanniae Preparata, 10 parts of Radix Notoginseng.
The preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease, step is as follows: weighs each raw material in proportion, cleaning is dry Only, pulverize, mix homogeneously, insert in container, add 42 ° of airtight immersions of Chinese liquor 50 days, quality of white spirit is 18 times of quality of medicinal material, Stir 1 time within every 7 days, take supernatant, squeeze medicinal residues, filter, press liquor is merged with supernatant, filling and sealing is standby.
Multiple toxicity test and clinic have been carried out to the medicated wine of the treatment rheumatic and rheumatoid disease of present invention preparation Test, the objective foundation for the curative effect of medicated wine provides science.
(1) toxicity test
1. animal acute toxicity test:
Experimental raw: the medicated wine of the embodiment of the present invention 1 preparation；The white mice of health, body weight in 40-50g, male and female half and half, There is provided by Medical University Of Anhui.
Experimental procedure: white mice adaptability feeds 1 week, is randomly divided into 5 groups, every group 10.After stopping feeding 15h, according to 5ml/ only feeds medicated wine, and the 1st, 2,3,4,5 groups feed medicated wine 1,2,3,4,5 times respectively in 24h respectively, after feeding end, institute There are the equal free water of white mice and feed, observe 5 days, observe the situations such as white mice body weight, hair, ergasia.
Experimental result: after feeding medicated wine 24h, the non-evident sympton such as white mice body weight, hair, diet and activity normal, no Toxic reaction, no dead.The medicated wine no acute toxicity of the embodiment of the present invention 1, clinical medicine dose safety are described.
2. long-term toxicity test for animals:
Experimental animal: the medicated wine of the embodiment of the present invention 1 preparation；Healthy white rat, in 120-130g, male, by pacifying for body weight Emblem medical university provides.
Experimental procedure: rat adaptability feeds 1 week, is randomly divided into 5 groups, every group 10.Wherein the 1st, 2,3,4 groups of conducts Administration group, every group feeds medicated wine 4ml, 6ml, 8ml, 10ml respectively, and the 5th group of diet as a control group, once a day, connects Continue and feed 90 days, survey body weight, put to death within latter 24 hours in last administration, survey blood, routine urinalysis, liver function, renal function, core, The internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, the change of activity.
Result of the test: it is observed that administration group compares all no significant changes it is seen that by kg body weight with matched group indices Calculate the equal non-toxic reaction of dosage with respect to clinical 50-200 times, safety.
(2) clinical experiment
Find through the detection of drug effect and clinical case, the Chinese medicine composition best results in embodiment 1.
1st, clinical case: select 400 patients suffering from rheumatic and rheumatoid disease, wherein male 181, women 219 Example, the age 28-65 year between, the mean age be 38.2 years old, the course of disease 3 months -6 years, clinical symptoms are presented with: patient part pain Bitterly, swelling or even function limitation.Western medicine diagnose is 226 of rheumatism, is diagnosed as 174 of atrophic diseases.
Therapeutic Method: above patient is treated using medicated wine prepared by the embodiment of the present invention 1, according to disease serious journey Degree, drink daily the embodiment of the present invention 1 preparation medicated wine, noon, evening respectively once, each 10-50g, the medicated wine amount of drinking 500g For a course for the treatment of, treat the 1-4 course for the treatment of, drink 7-20 days and can take effect.
Criterion of therapeutical effect: cure: sign symptom is improved completely, pain disappears, the abnormal sensory such as limbs no numbness；Effective: body Levy and symptom significantly improves, pain disappears substantially, the abnormal sensory such as limbs no numbness；Effective: sign and symptom have change, random thoughts Slightly uncomfortable, but can accept；Invalid: sign no changes, symptom is no improved.
Therapeutic outcome: 1 course for the treatment of treated by the medicated wine using the present invention, cures 40, effective 88, effective 172；4 The course for the treatment of cures 162, and effective 127, effective 96, invalid 15, total effective rate reaches 96.25%.
In sum, medicated wine of the present invention has preferable curative effect for rheumatism, atrophic diseases, and after treatment, patient's faces Bed symptom is obviously improved.
2nd, typical case:
Case 1: Liu so-and-so, female, 42 years old, be Jieshou City Dongcheng office great Lv administrative village great Lv people.On 2 5th, 2012 Because " each ankylosises of extremity, pain 5 years, increase 10 days " is admitted to hospital.5 years causes of patient are affected by the cold and cause each joint of extremity to walk to alter Pain cool in nature, did not attached the importance at that time, bad when good during the state of an illness between 5 years, gave medicine, acupuncture etc. to process in local hospital, readme is Take a turn for the better but effected a radical cure, for a long time with oral drugs relief of symptoms at all.Before 10 days, patient's sense each ankylosises of extremity, pain add Weight, oral drugs are no alleviated, and treat further for asking, and go to a doctor in hospital, intend accepting for medical treatment with " rheumatoid arthritiss " being admitted to hospital.
Have a medical check-up: extremity multi-joint swelling, morning stiffness, pain, with both shoulders, elbow, wrist, metacarpophalangeal joints, nearly DIPJ, Based on knee joint, ankle, toe joint, and with joint stuffiness.
Auxiliary examination: rf (+), crp (+), erythrocyte sedimentation rate: 22mm/h.
Medicated wine using the embodiment of the present invention 1 preparation is treated, and the while in hospital gives patient and drinks medicine of the present invention daily Wine, daily 2 times, each 50g, treated for 3 week, is aided with needle-knife solution art treatment local joint swelling and pain, extremity during discharge Each ankylosises pain substantially mitigates, and joint motion freely, advises functional activity to take exercise, after 1 month, follow-up conditions of patients obtains substantially To effective control, rheumatism five indices are normal, advise it to consolidate 1 course for the treatment of after 2 months again, follow-up reaches clinical cure.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality Body or operation are made a distinction with another entity or operation, and not necessarily require or imply these entities or deposit between operating In any this actual relation or order.And, term " inclusion ", "comprising" or its any other variant are intended to Comprising of nonexcludability, wants so that including a series of process of key elements, method, article or equipment and not only including those Element, but also include other key elements being not expressly set out, or also include for this process, method, article or equipment Intrinsic key element.In the absence of more restrictions, the key element that limited by sentence "including a ..." it is not excluded that Also there is other identical element including in the process of described key element, method, article or equipment.
Above example only in order to technical scheme to be described, is not intended to limit；Although with reference to the foregoing embodiments The present invention has been described in detail, it will be understood by those within the art that: it still can be to aforementioned each enforcement Technical scheme described in example is modified, or carries out equivalent to wherein some technical characteristics；And these modification or Replace, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.

Claims (5)

1. a kind of medicated wine treating rheumatic and rheumatoid disease is it is characterised in that be made up of the raw material of following weight portion: Rhizoma Fagopyri Dibotryiss 45-55 part, Radix Achyranthis Bidentatae 90-110 part, Radix Polygoni Multiflori 30-40 part, Poria 8-12 part, Rhizoma Polygoni Cuspidati 90-110 part, Bulbus Lilii 14-16 part, Fructus Alpiniae Oxyphyllae Core 30-40 part, Radix Angelicae Sinensis 10-20 part, Radix Dipsaci 20-30 part, Cortex Eucommiae 8-15 part, Fructus Lycii 90-110 part, Semen Euryaless 30-40 part, Fructus Jujubae 90-110 part, Herba Portulacae 30-40 part, Rhizoma Smilacis Chinensiss 45-55 part, Cortex Acanthopanciss 4-6 part, Caulis Spatholobi 90-110 part, Sabia schumanniana Diels 30-40 part, Radix Rehmanniae Preparata 10-15 part, Radix Notoginseng 10-15 part.
2. the medicated wine for the treatment of rheumatic and rheumatoid disease as claimed in claim 1 is it is characterised in that former by following weight portion Material composition: 50 parts of Rhizoma Fagopyri Dibotryiss, 100 parts of Radix Achyranthis Bidentatae, 35 parts of Radix Polygoni Multiflori, 10 parts of Poria, 100 parts of Rhizoma Polygoni Cuspidati, 15 parts of Bulbus Lilii, Fructus Alpiniae Oxyphyllae 35 Part, 15 parts of Radix Angelicae Sinensis, 25 parts of Radix Dipsaci, 10 parts of the Cortex Eucommiae, 100 parts of Fructus Lycii, 35 parts of Semen Euryaless, 100 parts of Fructus Jujubae, 35 parts of Herba Portulacae, Rhizoma Smilacis Chinensiss 50 parts, 5 parts of Cortex Acanthopanciss, 100 parts of Caulis Spatholobi, 35 parts of Sabia schumanniana Diels, Radix Rehmanniae Preparata 10-15 part, Radix Notoginseng 10-15 part.
3. the preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease as claimed in claim 1 or 2 is it is characterised in that walk Suddenly as follows: to weigh each raw material in proportion, clean up, pulverize, mix homogeneously, insert in container, add the airtight immersion 50 of Chinese liquor My god, stir 1 time within every 7 days, take supernatant, squeeze medicinal residues, filter, press liquor is merged with supernatant, filling and sealing is standby.
4. the preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease as claimed in claim 3 is it is characterised in that described white The number of degrees of wine are 38 ° -52 °.
5. the preparation method of the medicated wine for the treatment of rheumatic and rheumatoid disease as claimed in claim 3 is it is characterised in that described white Wine consumption is 16-20 times of medical material.
CN201610960525.9A 2016-10-28 2016-10-28 Medicinal liquor for treatment of rheumatic and rheumatoid diseases and preparation method thereof Pending CN106362066A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107890533A (en) * 2017-12-20 2018-04-10 庄巍 A kind of Chinese medicine composition for treating rheumatism and preparation method thereof
CN111093398A (en) * 2017-09-14 2020-05-01 韩国韩医学研究院 Composition for preventing, improving or treating osteoarthritis containing Alpinia oxyphylla extract as active ingredient

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101099794A (en) * 2007-07-24 2008-01-09 蔡然 Medicine for treating rheumatic arthritis and rheumatoid arthritis
CN102772574A (en) * 2012-08-05 2012-11-14 张永鹏 Preparation method of medicinal liquor for treating rheumatism and rheumatoid arthritis
CN104474048A (en) * 2014-11-20 2015-04-01 界首骨科医院 Palsy-removing medicinal liquor for enema treatment of rheumatoid arthritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101099794A (en) * 2007-07-24 2008-01-09 蔡然 Medicine for treating rheumatic arthritis and rheumatoid arthritis
CN102772574A (en) * 2012-08-05 2012-11-14 张永鹏 Preparation method of medicinal liquor for treating rheumatism and rheumatoid arthritis
CN104474048A (en) * 2014-11-20 2015-04-01 界首骨科医院 Palsy-removing medicinal liquor for enema treatment of rheumatoid arthritis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111093398A (en) * 2017-09-14 2020-05-01 韩国韩医学研究院 Composition for preventing, improving or treating osteoarthritis containing Alpinia oxyphylla extract as active ingredient
CN107890533A (en) * 2017-12-20 2018-04-10 庄巍 A kind of Chinese medicine composition for treating rheumatism and preparation method thereof

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