CN104758534A

CN104758534A - Medicine for treating osteoporosis and preparing method thereof

Info

Publication number: CN104758534A
Application number: CN201510209257.2A
Authority: CN
Inventors: 侯丽君; 赵振荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-29
Filing date: 2015-04-29
Publication date: 2015-07-08

Abstract

The invention discloses medicine for treating the osteoporosis and a preparing method thereof. The medicine is made of radix aconiti lateralis preparata, Himalaya mirabilis jalapa, dogwood, rust-coloured crotalaria herbs with roots, barbary wolfberry fruits, deer kidneys, semen cuscutae, actinolite, cowpea, japanese balanophora, poria with hostwood, pyrola, rhizoma cyperi, finest cream, polygala tenuifolia, human placenta, spina date seeds, caraway, longan aril, mangnolia officinalis, lucid ganoderma, rhizoma alismatis, cornu cervi degelatinatum, polygonum multiflorum, Tibetan hawksbeard roots, colla corii asini, cordyceps sinensis, oyster-cap fungus, hairyvein agrimony, deer tails, fruits of highland barley malt, acanthopanax, fructus alpiniae oxyphyllae, cibotium barometz, eucommia ulmoides and fructus psoraleae. The medicine has the advantages that the effect of invigorating the spleens and the kidneys is achieved, and the effects of strengthening kidney qi, warming and invigorating kidney yang, strengthening tendons and bones, tonifying qi and augmenting force are achieved at the same time; in addition, the medicine can tonify qi, nourish blood, regulate qi-flowing for strengthening the spleens, enhance resistance and have the advantages of being rapid in effect taking, high in efficiency, exact in treatment effect, short in treatment course, free of toxic and side effects, low in price and the like in the aspect of treating the osteoporosis.

Description

A kind of medicine for the treatment of osteoporosis and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind of medicine for the treatment of osteoporosis and preparation method thereof.

Background technology

Osteoporosis is one group of osteopathia that multiple reasons causes, and osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.Fall ill how slowly indivedual very fast, with skeleton pain, be easy to fracture for feature biochemical analysis is normal.The visible cortical bone of pathological anatomy is belittled, and bone trabecula sparse atrophy osteoid layer is not thick.Osteoporosis, primary osteoporosis be reduce with bone amount, the microstructure degeneration of bone is feature, cause the fragility of bone to increase and be easy to occur a kind of systemic skeletal disease of fracture.Alcoholic osteoporosis (AOP) refers to because long-term, a large amount of Ethanol intakes causes bone amount to reduce, the microstructural damage of bone, bone fragility increases, a kind of general bone metabolism disorder disease that risk of bone fracture increases, belong to secondary osteoporosis, also being low conversion type osteoporosis, is one of clinical common Alcoholic osteopathia.

The pathogenic factor of osteoporosis: 1, the shortage of calcium; 2, calcitonin; 3, vitamin D; 4, acidic physique.Vulnerable crowd: the risk factor of male is the age, body weight Height Ratio, and long-term alcohol, smoking, gives up doing exercise.The risk factor of women is the age, body weight Height Ratio, and age of menarche, menopause time, at the first tire age, parturition number, gives up doing exercise.Advanced age is the main risk factor of elderly men hip osteoporosis, and the longer post menopausal time is the main risk factor of old women hip osteoporosis.

The symptom of osteoporosis: (1) pain: the modal disease of primary osteoporosis, common with lumbago and backache, account for the 70%-80% in pain patients.Pain spreads along spinal column to both sides, lie on the back or seat time pain relief, stretch after time upright or standing for a long time, sitting time the pain increased, pain is light in the daytime, increases the weight of, bends over, muscular movement, cough, stool increase the weight of when exerting oneself when night and early morning wake up.Osteodynia can be there is when general bone loss more than 12%.During senile osteoporosis, the atrophy of vertebral bone girder, quantity reduces, and Vertebral Compression is out of shape, flexion of vertebral column, and waist rash flesh is in order to correct flexion of vertebral column, and double to shrink, muscle fatigue is spasm even, produces pain.Recently compressed fracture of thoracic vertebra and lumber vertebra, also can produce acute pain, and the spinous process of corresponding site can have strong tenderness and percussion pain, and general 2-3 Zhou Houke alleviates gradually, and some patients can be chronic back pain.If oppress corresponding spinal nerves can produce extremity radiating pain, two lower limb sensorimotor obstacle, intercostal neuralgia, the similar angina pectoris of retrosternal pain, the similar acute abdomen of upper abdominal pain also can be there is.If compressing spinal cord, horse hair are also middle affect bladder, rectum function.(2) height shortening, hunchback: how to occur after pain; Vertebra vertebral body front portion mostly almost is spongy bone composition, and this position is the pillar of health, and loading weight is large, easy compression, vertebra is leaned forward, and the bent aggravation of the back of the body, is formed bow-backed, with age, osteoporosis increases the weight of, and bow-backed curvature strengthens, and causes knee joint contraction to be arrested significantly.Everyone has 24 joint vertebral bodys, and each vertebral height of normal person is about about 2cm, Vertebral Compression during senile osteoporosis disease, and every vertebral body shortens about 2mm, height shorten in average 3-6cm.(3) fracture: this is the most common and the most serious complication of degeneration osteoporosis.(4) respiratory function declines: thoracolumbar vertebrae compression fracture, vertebra palintrope, and chest deformity, can make vital capacity and maximal breathing capacity significantly reduce, patient often can occur uncomfortable in chest, breathe hard, the symptom such as dyspnea.

The diagnosis of osteoporosis: the common index clinically for osteoporosis is: 1. fragility fractures: the fracture occurred when referring to non-wound or microtrauma, this is the obvious embodiment that bone strength declines.Also be final result and the complication of osteoporosis.Common is wrist (distal radius), vertebral body, hip (proximal femur).There occurs fragility fractures and can be diagnosed as osteoporosis.2. based on the diagnostic criteria of bone densitometry: the diagnostic criteria of world health organisation recommendations: bone density belongs to normal (T value ﹥-1) less than a standard deviation lower than same sex, agnate normal person's peak bone mass, bone density value is for bone amount reduces (-2.5<T is worth <-1) between-1 ~-2.5, and bone density is osteoporosis (T value≤2.5) less than or equal to-2.5.Bone density reduce degree meet diagnosis of osteoporosis standard simultaneously with a place or repeatedly fracture time be serious osteoporosis.Typical X-ray photo can show that tubulose cortical bone is thinning, and pulp cavity broadens, bone trabecula decreased number, and its gap is also broadening.

The osteoporosis pathology cause of disease: the cause of disease of primary osteoporosis is not bright, may with following a kind or several factors relevant.1. endocrine function is not normal.(1) sex hormone deficiency: estrogen and (or) hypoandrogenism and out of proportion, cause: 1. protein synthesis reduces, bone matrix generates not enough; 2. function of osteoblast declines; 3. PTH increases the sensitivity of bone effect; 4. glucocorticoids on bone action intensity increases relatively; 5. intestinal calcium absorption and renal tubules calcium heavily absorb reduction, and the osteoporosis that menopause, senile and premature ovarian failure etc. cause all may be relevant therewith, and estrogen deficiency may be the main cause of postmen opausal.(2) PTH secretion increasing: the blood PTH of some primary osteoporosiies (bone high-conversion rate osteoporosis) person slightly increases, this is more obvious in the patient of senile renal hypofunction and impaired glucose tolerance; Add the reasons such as sex hormone deficiency, PTH and gonadal hormone ratio are not normal, can osteoporosis be caused.(3) calcitonin (CT) lacks: after menopause, CT level reduces, and may facilitate the generation of osteoporosis because suppressing bone resorption factor reduction.(4) other functionss of hormones: some data show, there is the diacrisis of thyroxin, glucocorticoid, growth hormone, Lifestyle factor (especially somatomedin C), gastrin in Osteoporosis, but its causal significance is not illustrated.Osteoblast (OB) and osteoclast (OC) form bone reconstructive unit.Break bone and osteogenetic process keeps balancing in health adult, this depends on OB and OC good mutual adjustment each other.Osteoclast belongs to the cell of monocyte/macrophage pedigree, plays a crucial role in maintenance bone remoulding balance and body in calcium balance.The activation of OC and suppressedly to regulate by OB and other factors again.The stromal cell of bone, osteoblast and the activation of Activated T-lymphocytes to OC play supporting function, are called as " supporting carefully to roar " (SC/OB).1. " sustenticular cell " secretes M-CSF (M-CSF) stimulates multipotency monocyte/macrophage pedigree to grow for OC precursor.2. " sustenticular cell " RANKL [nuclear factor-κ B (NF-κ B) receptor activation factor aglucon of secreting, also known as OPG aglucon (OPGL), OC differentiation factor] combine with the RANK [(NF-κ B) the receptor activation factor] on OC film, import signal into osteoclast precursor, make OC differentiation and maturation.3. " sustenticular cell " secretes again OPG (OPG, osteoprotection), fights for the combination of RANK with OPGL, thus suppresses the differentiation and maturation of OC.Various upstreams hormone is [as PTH, 17 β-E2, glucocorticoid, l, 25 (OH) 2D3, PGE2 etc.] or cytokine (as TGF-β, IL-1, IL-11, IL-17 and TNF etc.) act on the receptor of SC/OB, stimulate or suppress SC/OB to express RANKL or 0PG, thus regulating the activity of OC.Then osteoporosis is there is as OC is too active constantly.2. malnutrition is due to a variety of causes, and old people, adolescence and edge design malnutrition can occur.Protein undersupply may cause osteogenesis obstacle, but take in too much protein also make urine calcium discharge increase, cause calcium negative balance.The Deficiency of Intake of calcium and the in close relations of osteoporosis, low calcium diet can cause bone resorption to accelerate by Secondary cases PTH secretion increasing.Drink and glucocorticoid secretion is increased, urine calcium increases, and intestinal calcium absorption reduces; Long-term alcohol person hypogonadism, as concurrent liver cirrhosis also will affect the generation of 25-(OH) D3; Therefore the cause of disease of alcoholic-toxic osteoporosis is the consequence of many-sided comprehensive function.The factors such as the activity of old people reduces, sunshine lacks, gastrointestinal absorption function and reabsorption ability go down year by year, all may with osteoporosis be formed with certain relation.3. inherited genetic factors stature, the girth of a garment, muscular degree are all relevant with heredity with gastrointestinal function.Easily there is osteoporosis in white people (Aisan also approximate white people), and osteoporosis not easily occurs for South Africa Bantu, Black people, and tall and thin stature person osteoporosis incidence rate is more much higher than podge.4. immune factor osteoclast derives from large mononuclear cell, has potential immunologic function.During immunologic function disorder, accelerated bone absorbs by all means, delays osteogenesis and causes.

The prevention of osteoporosis: 1, discontinue the habit of smoking and drinking, drinks less containing coffee-type beverage.2, suitably carry out outdoor activities, expose to sunlight.3, physical exertion and exercise is strengthened.The function of skeletal system is born a heavy burden and motion.Musculation is more, and just reach all the more, skeleton is also more sturdy.Motion exercise can slow down aging, reduces bone calcium " overdraw ".4, be careful in one's diet allotment.Eat the food of rich in protein more, as milk, eggs, lean meat, poultry meat and fish and shrimp etc., and the food that calcium content is abundant, as milk, Radix Raphani, Caulis et Folium Brassicae junceae, Brassica oleracea L.var.capitata L., Caulis et Folium Brassicae capitatae and various bean product etc.Reduce Sal to take in, with calcareous in holding body, note Mg supplementation and manganese simultaneously.

The pathogenesis of osteoporosis: non-single factors is caused a disease.Participate in pathogenic comprising: 1. inherited genetic factors; 2. the shortage of calcium and vitamin D; 3. oestrogen deficiencies causes osteoporosis, and estrogen replacement curative effect is obviously recognized; 4. hypoandrogenism also participates in Male Osteoporosis; 5. old degenerative mechanism etc.The generation of senile osteoporosis is lacked of proper care with human endocrine, hypokinesia is relevant with bad life habits.Therefore, the bone loss rule occurred with age increase is understood significant to this disease of control.Therefore, bone condention just becomes the important means of research osseous lesion.Bone trabecula bone volume (TBV) is the important parameter that in reflection unit volume medullary cavity, bone volume is how many.TBV partly can only reflect the change that bone trabecula bone amount occurred with the age, because have certain overlap between each age group.The result that we measure shows, more than 50 years old group male TBV comparatively the right side of fifty group decreases about 1/4, and women declines more hurry up.Women's post menopausal reduces rapidly due to estrogen, and bone loss is accelerated, and this stage is called that bone amount lowers the phase rapidly.Average bone wall thickness (MWT) is another important parameter.Our result of study shows, this parameter increases with the age and declines, and women declines more obvious, therefore women's post menopausal male more of the same age more easily pathologisch Bruch occurs.

The drug treatment of osteoporosis: to the treatment of osteoporosis from the postponement generation of osteoporosis and the therapeutic advance of deterioration to the treatment recovering bone health energetically.What make " life expectancy of people can be made to extend 10-20 from the bone life-span " wants to be possibility in advance.Join for osteoporosis patients bone resorption and bone formation corner and lack of proper care, Drug therapy is divided into three major types: 1, bone resorption inhibitor, to reduce the further loss of bone amount: estrogen, calcitonin, diphosphate, ipriflavone all belong to this class; 2, bone formation-promoter, to increase bone amount, comprises fluoride, vitamin K, parathyroid hormone, androgen, growth hormone etc.; 3, bone mineralising promoter, promotes bone calcific deposit, and increase bone amount, this kind of medicine has vitamin D and calcium preparation.What need special proposition is, previously HRT(Hormone Replacement Therapy) Zeng Zuowei treatment female postmenopausal osteoporosis first-selection, but new research shows, at HRT(Hormone Replacement Therapy) as in a line medication of osteoporosis, risk-ratio of being benefited is undesirable.In the preventing and treating of osteoporosis, in European scale, HRT is not re-used as a gamma therapy of osteoporosis.

The western medicine therapy for the treatment of osteoporosis is: constitutional I type osteoporosis belongs to hypermetabolism type, is because postmenopausal estrogen reduces, makes that bone resorption is hyperfunction causes bone loss, bone resorption inhibitor therefore should be selected as estrogen, calcitonin, calcium preparation.Constitutional II type osteoporosis, its cause of disease is that application bone formation-promoter, as activated vitamin D, protein anabolic hormone (nandrolone phenylpropionate), calcium preparation, fluorization agent and Menaquinone K6 etc. because the increasing aging caused hormone imbalances that regulates in age makes bone formation low.1, estrogen: the choice drug being control postmenopausal osteoporosis.(1) estradiol 1-2mg/d.(2) diethylstilbestrol 0.25mg/ every night.(3) compound recipe estrogen 0.625mg/d.(4) nilestriol 2mg/ first quarter moon.(5) livial.2, calcitonin: (1) calcitonin.(2) elcatonin.(3) Calcitonin.3, Vir D: (1) Rocaltrol.(2) alfacalcidol.4, calcium preparation: (1) inorganic calcium: 1) calcium chloride.2) calcium carbonate.(2) organic calcium: 1) calcium gluconate.2) calcium lactate.3) C8H12CaN2O8.(3) activated calcium.(4) Gaierqi D (vitamin D3 and calcium carbonate).5, Diphosphonate: (1) clodronic acid disodium.(2) ethoxy diphosphate sodium.6, ipriflavone.

But western medicine: trace elements absorption situation is uncertain, affects appetite, cures the symptoms, not the disease, is unfavorable for treatment, and conventional there are dependency and side effect.

Summary of the invention

Technical problem to be solved by this invention is, a kind of medicine for the treatment of osteoporosis and preparation method thereof is provided, the present invention has effect of invigorating spleen and kidney, have the effect of strong kidney qi, warming and recuperating the kidney-YANG, strong muscles and bones, QI invigorating reinforcement concurrently, in addition, can also benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen, strengthen its resistivity, have in treatment osteoporosis rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of osteoporosis, wherein, following raw medicinal material is comprised: Radix Aconiti Lateralis Preparata, Radix Mirabilis himalaicae, Fructus Corni, Herba Crotalariae Ferrugineae, Fructus Lycii, Penis et testis cervi, Semen Cuscutae, Actinolitum, Semen vignae sinensis, Herba balanophorae japonicae, Poria cum Radix Pini, Herba Pyrolae, Rhizoma Cyperi, milk, Radix Polygalae, Placenta Hominis, Semen Ziziphi Spinosae, Fructus cari carvi, Arillus Longan, Cortex Magnoliae Officinalis, Ganoderma, Rhizoma Alismatis, Cornu Cervi Degelatinatum, Radix Polygoni Multiflori, Radix Crepidis elongatae, Colla Corii Asini, Cordyceps, to pick up the ears and Herba Agrimoniae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 10 ~ 22 parts, Radix Mirabilis himalaicae 15 ~ 35 parts, Fructus Corni 10 ~ 25 parts, Herba Crotalariae Ferrugineae 12 ~ 32 parts, Fructus Lycii 15 ~ 40 parts, Penis et testis cervi 11 ~ 31 parts, Semen Cuscutae 10 ~ 30 parts, Actinolitum 20 ~ 40 parts, Semen vignae sinensis 7 ~ 20 parts, Herba balanophorae japonicae 14 ~ 34 parts, Poria cum Radix Pini 12 ~ 22 parts, Herba Pyrolae 13 ~ 33 parts, Rhizoma Cyperi 12 ~ 24 parts, milk 16 ~ 38 parts, Radix Polygalae 14 ~ 24 parts, Placenta Hominis 10 ~ 20 parts, Semen Ziziphi Spinosae 15 ~ 35 parts, Fructus cari carvi 10 ~ 20 parts, Arillus Longan 11 ~ 31 parts, Cortex Magnoliae Officinalis 14 ~ 36 parts, Ganoderma 15 ~ 25 parts, Rhizoma Alismatis 12 ~ 32 parts, Cornu Cervi Degelatinatum 12 ~ 26 parts, Radix Polygoni Multiflori 7 ~ 15 parts, Radix Crepidis elongatae 12 ~ 32 parts, 10 ~ 20 parts, Colla Corii Asini, Cordyceps 20 ~ 45 parts, to pick up the ears 12 ~ 22 parts and Herba Agrimoniae 15 ~ 35 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 12 ~ 20 parts, Radix Mirabilis himalaicae 15 ~ 30 parts, Fructus Corni 15 ~ 22 parts, Herba Crotalariae Ferrugineae 14 ~ 30 parts, Fructus Lycii 15 ~ 40 parts, Penis et testis cervi 12 ~ 31 parts, Semen Cuscutae 15 ~ 30 parts, Actinolitum 25 ~ 40 parts, Semen vignae sinensis 10 ~ 20 parts, Herba balanophorae japonicae 15 ~ 35 parts, Poria cum Radix Pini 14 ~ 24 parts, Herba Pyrolae 15 ~ 32 parts, Rhizoma Cyperi 14 ~ 22 parts, milk 18 ~ 36 parts, Radix Polygalae 15 ~ 24 parts, Placenta Hominis 12 ~ 20 parts, Semen Ziziphi Spinosae 15 ~ 35 parts, Fructus cari carvi 14 ~ 20 parts, Arillus Longan 12 ~ 30 parts, Cortex Magnoliae Officinalis 15 ~ 35 parts, Ganoderma 15 ~ 25 parts, Rhizoma Alismatis 14 ~ 30 parts, Cornu Cervi Degelatinatum 14 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Radix Crepidis elongatae 14 ~ 32 parts, 12 ~ 20 parts, Colla Corii Asini, Cordyceps 20 ~ 42 parts, pick up the ears 14 ~ 20 parts, Herba Agrimoniae 15 ~ 35 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 15 parts, Radix Mirabilis himalaicae 30 parts, Fructus Corni 22 parts, Herba Crotalariae Ferrugineae 30 parts, Fructus Lycii 40 parts, Penis et testis cervi 22 parts, Semen Cuscutae 25 parts, Actinolitum 35 parts, Semen vignae sinensis 15 parts, Herba balanophorae japonicae 32 parts, Poria cum Radix Pini 22 parts, Herba Pyrolae 32 parts, Rhizoma Cyperi 15 parts, milk 35 parts, Radix Polygalae 22 parts, Placenta Hominis 15 parts, Semen Ziziphi Spinosae 35 parts, Fructus cari carvi 14 parts, Arillus Longan 22 parts, Cortex Magnoliae Officinalis 33 parts, Ganoderma 25 parts, Rhizoma Alismatis 30 parts, Cornu Cervi Degelatinatum 20 parts, Radix Polygoni Multiflori 12 parts, Radix Crepidis elongatae 32 parts, 20 parts, Colla Corii Asini, Cordyceps 40 parts, to pick up the ears 15 parts and Herba Agrimoniae 30 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 20 parts, Radix Mirabilis himalaicae 15 parts, Fructus Corni 22 parts, Herba Crotalariae Ferrugineae 30 parts, Fructus Lycii 20 parts, Penis et testis cervi 31 parts, Semen Cuscutae 30 parts, Actinolitum 25 parts, Semen vignae sinensis 20 parts, Herba balanophorae japonicae 15 parts, Poria cum Radix Pini 24 parts, Herba Pyrolae 15 parts, Rhizoma Cyperi 22 parts, milk 35 parts, Radix Polygalae 15 parts, Placenta Hominis 20 parts, Semen Ziziphi Spinosae 35 parts, Fructus cari carvi 15 parts, Arillus Longan 30 parts, Cortex Magnoliae Officinalis 33 parts, Ganoderma 22 parts, Rhizoma Alismatis 30 parts, Cornu Cervi Degelatinatum 25 parts, Radix Polygoni Multiflori 10 parts, Radix Crepidis elongatae 32 parts, 14 parts, Colla Corii Asini, Cordyceps 42 parts, to pick up the ears 20 parts and Herba Agrimoniae 35 parts.

In described medicine, each raw medicinal material also comprises: Cauda cervi, Fructus Hordei nudi Germinatus, Radix Et Caulis Acanthopanacis Senticosi, Fructus Alpiniae Oxyphyllae, Rhizoma Cibotii, the Cortex Eucommiae and Fructus Psoraleae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 12 ~ 20 parts, Radix Mirabilis himalaicae 15 ~ 30 parts, Fructus Corni 15 ~ 22 parts, Herba Crotalariae Ferrugineae 14 ~ 30 parts, Fructus Lycii 15 ~ 40 parts, Penis et testis cervi 12 ~ 31 parts, Semen Cuscutae 15 ~ 30 parts, Actinolitum 25 ~ 40 parts, Semen vignae sinensis 10 ~ 20 parts, Herba balanophorae japonicae 15 ~ 35 parts, Poria cum Radix Pini 14 ~ 24 parts, Herba Pyrolae 15 ~ 32 parts, Rhizoma Cyperi 14 ~ 22 parts, milk 18 ~ 36 parts, Radix Polygalae 15 ~ 24 parts, Placenta Hominis 12 ~ 20 parts, Semen Ziziphi Spinosae 15 ~ 35 parts, Fructus cari carvi 14 ~ 20 parts, Arillus Longan 12 ~ 30 parts, Cortex Magnoliae Officinalis 15 ~ 35 parts, Ganoderma 15 ~ 25 parts, Rhizoma Alismatis 14 ~ 30 parts, Cornu Cervi Degelatinatum 14 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Radix Crepidis elongatae 14 ~ 32 parts, 12 ~ 20 parts, Colla Corii Asini, Cordyceps 20 ~ 42 parts, pick up the ears 14 ~ 20 parts, Herba Agrimoniae 15 ~ 35 parts, Cauda cervi 10 ~ 25 parts, Fructus Hordei nudi Germinatus 10 ~ 32 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 25 parts, Fructus Alpiniae Oxyphyllae 10 ~ 15 parts, Rhizoma Cibotii 20 ~ 35 parts, the Cortex Eucommiae 10 ~ 22 parts and Fructus Psoraleae 10 ~ 30 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 12 parts, Radix Mirabilis himalaicae 25 parts, Fructus Corni 20 parts, Herba Crotalariae Ferrugineae 30 parts, Fructus Lycii 40 parts, Penis et testis cervi 14 parts, Semen Cuscutae 25 parts, Actinolitum 35 parts, Semen vignae sinensis 12 parts, Herba balanophorae japonicae 30 parts, Poria cum Radix Pini 22 parts, Herba Pyrolae 32 parts, Rhizoma Cyperi 20 parts, milk 35 parts, Radix Polygalae 22 parts, Placenta Hominis 15 parts, Semen Ziziphi Spinosae 25 parts, Fructus cari carvi 14 parts, Arillus Longan 30 parts, Cortex Magnoliae Officinalis 25 parts, Ganoderma 17 parts, Rhizoma Alismatis 30 parts, Cornu Cervi Degelatinatum 14 parts, Radix Polygoni Multiflori 13 parts, Radix Crepidis elongatae 30 parts, 15 parts, Colla Corii Asini, Cordyceps 35 parts, pick up the ears 20 parts, Herba Agrimoniae 35 parts, Cauda cervi 14 parts, Fructus Hordei nudi Germinatus 32 parts, Radix Et Caulis Acanthopanacis Senticosi 22 parts, Fructus Alpiniae Oxyphyllae 14 parts, Rhizoma Cibotii 32 parts, the Cortex Eucommiae 22 parts and Fructus Psoraleae 25 parts.

Described medicine composition dosage form is granule, and its preparation method is:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Cordyceps, pick up the ears, Herba Agrimoniae, Cauda cervi, Fructus Hordei nudi Germinatus, Radix Et Caulis Acanthopanacis Senticosi, Fructus Alpiniae Oxyphyllae, Rhizoma Cibotii, the Cortex Eucommiae and Fructus Psoraleae mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, dealcoholation treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.

The invention has the beneficial effects as follows: the present invention has effect of invigorating spleen and kidney, have the effect of strong kidney qi, warming and recuperating the kidney-YANG, strong muscles and bones, QI invigorating reinforcement concurrently, in addition, can also benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen, strengthen its resistivity, have in treatment osteoporosis rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

Tool of the present invention follows the Therapeutic Principle of invigorating spleen and kidney, have strong kidney qi concurrently, warming and recuperating the kidney-YANG, strong muscles and bones, the effect of QI invigorating reinforcement, wherein, comprise following raw medicinal material: Radix Aconiti Lateralis Preparata, Radix Mirabilis himalaicae, Fructus Corni, Herba Crotalariae Ferrugineae, Fructus Lycii, Penis et testis cervi, Semen Cuscutae, Actinolitum, Semen vignae sinensis, Herba balanophorae japonicae, Poria cum Radix Pini, Herba Pyrolae, Rhizoma Cyperi, milk, Radix Polygalae, Placenta Hominis, Semen Ziziphi Spinosae, Fructus cari carvi, Arillus Longan, Cortex Magnoliae Officinalis, Ganoderma, Rhizoma Alismatis, Cornu Cervi Degelatinatum, Radix Polygoni Multiflori, Radix Crepidis elongatae, Colla Corii Asini, Cordyceps, pick up the ears, Herba Agrimoniae, Cauda cervi, Fructus Hordei nudi Germinatus, Radix Et Caulis Acanthopanacis Senticosi, Fructus Alpiniae Oxyphyllae, Rhizoma Cibotii, the Cortex Eucommiae and Fructus Psoraleae.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Pick up the ears: another name: Fungus Pleurotus ostreatus, oyster bacterium, assorted mushroom.Source: Mycophyta Basidiomycetes Agaricales Agaricaceae is picked up the ears Pleurotus ostreatus (Jacq. ex Fr.) Quel., is used as medicine with sporophore.Nature and flavor: micro-salty, temperature.Cure mainly: chase after wind, cold expelling, relaxing muscles and tendons, active.

Milk: source: Lei Gong's Treatise on Preparation and Broiling of Materia Medica.Source: the edible fat made for Lac Bovis seu Bubali.Nature and flavor: 1. " a thousand pieces of gold dietetic therapy ": " sweet in the mouth is flat, nontoxic." cure mainly: support battalion, YIN nourishing, moisturizes, and quenches the thirst.Control asthenia consumptive lung disease, spitting bloody pus, quench one's thirst, constipation, migratory arthralgia, skin pruritus.

Herba balanophorae japonicae: source: come from supplementary Amplifications of the Compendium of Materia Medica.1. " detailed outline ": Flos puerariae lobatae dish, all famous mountains all have it, and only Tai Heshan takes, cloud be the elite of Pueraria lobota also.Frost in autumn floating, as sesame bacterium is gushed on the Radix Rehmanniae, its red complexion is crisp, and lid Mushrooms also.2. " detailed outline is picked up any lost article from the road ": Flos puerariae lobatae dish, famous mountain all has, and also produces Gaozhou county." Guangdong will ", the multiple Pueraria lobota in Gaozhou county, labor market, Leizhou be XIGU.Source: medical material Ji Yuan: be the herb of the red winter Balaenoptera borealis Lesson of Balanophoraceae plant.Nature and flavor: bitter; Puckery; Cold in nature.Gui Jing: lung; Large intestine channel.Cure mainly: cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main cough spitting of blood; Metrorrhagia; Discharging fresh blood stool; Swelling and pain of hemorrhoid; Prunus mume (sieb.) sieb.et zucc. poison; Treat skin ulcer; Child penis swells.

Fructus Hordei nudi Germinatus: source: " not Lu ".Another name: Fructus Hordei Germinatus (" detailed outline ").Source: be the germination caryopsis of grass naked barley.Nature and flavor: 1. " not Lu ": " temperature." 2. " detailed outline ": " is salty, temperature, nontoxic." cure mainly: help digestion, and in.Control food stagnation distension, inappetence, vomiting is had loose bowels.1. " not Lu ": " help digestion and in." 2. " property of medicine opinion ": " breaks cold air, removes trusted subordinate's distension." 3. " Japan hanako materia medica ": " whets the appetite, only cholera, and except unhappy, expectorant is drunk, and broken disease is amassed, and can expedite the emergence of tire." 4. Zhang Yuansu: " spleen reinforcing insufficiency of stomach, the wide intestinal therapeutic method to keep the adverse QI flowing downwards, borborygmus person uses it." 5. " detailed outline ": " digests all fruit food stagnations of all rice and flour."

The Cortex Eucommiae: another name: pull a skin, think the second month in a season, silk flosssilk wadding skin, beautiful silk skin.Source: this product is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..4 ~ June strips, and scrapes off rough bark, and " diaphoresis " to endothelium of banking up is puce, dries.Nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.

Fructus Alpiniae Oxyphyllae: source: " must book on Chinese herbal medicine be joined ".Another name: Fructus Alpiniae Oxyphyllae (" Kaibao Bencao ") ， Zhai Ding (" Chinese crude drug handbook ").Source: be the fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.Harvesting when fruit is brown, White flesh minimizing between 5 ~ June, removing fruit stem, dries.Nature and flavor: pungent, temperature.1. " southern vegetation shape ": " acrid in the mouth." 2. TAO Hong-Jing: " heat." 3. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 4. " book on Chinese herbal medicine is just read ": " acrid in the mouth is bitter, hot in nature." return through: enter spleen, kidney channel.Cure mainly: warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.1. " wide will ": " take the photograph saliva containing it dirty." 2. supplement to the Herbal: " preventing or arresting vomiting is vomited." " controls seminal emission false leak, dribbling urination, benefiting vital QI for tranquillizing, tonifying for the deficiency, and profit three is burnt, adjusts all gas, night many urinators, get 24 pieces broken, enter the same decoction of salt." 3. Liu Wansu: " develops pent-up, gas is declared logical."

Cornu Cervi Degelatinatum: source: this product is that Cornu Cervi removes photoresist the hornblock (boil Colla cornus cervi remaining bone slag) of matter.Spring, Qiu Erji produce, and matter of removing photoresist is endured at ossified angle, take out hornblock, dry.Nature and flavor: salty, temperature.Gui Jing: return liver, kidney channel.Cure mainly: warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule.

Cauda cervi: source: " Qinghai medical material ".Source: be the tail of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus, cut off by pygostyle by Cauda cervi, hang-up is dried in the shade; The band hair Cauda cervi maybe will cut off, enters in water and infiltrates, and takes out, and the residual meat of removing root, oils and fats, cut off young pilose antler and outside Lao Pi, then rub light with the hands with Pumex, wears extension ventilation dry in the shade with line, and rearmounted drying place, should ted more.Commodity, the former claims " band hair Cauda cervi "; The latter claims " not being with a mao Cauda cervi ".Nature and flavor: 1. " Qinghai medical material ": " warm in nature, nontoxic." 2. " Traditional Chinese Medicine in Sichuan will ": " sweet-salty." curing mainly: 1. " Qinghai medical material ": " is tonic.Control lumbago, sexual impotence." 2. " Traditional Chinese Medicine in Sichuan will ": " warms up waist knee joint, and kidney tonifying essence, controlling lumbar vertebrae pain can not bend and stretch, emission due to deficiency of the kidney and dizzy tinnitus."

Cordyceps: another name: Cordyceps, Cordyceps, Cordyceps sinensis.Source: this product is that section ergot fungus cordyceps sinensis bacterium Cordyceps sinensis (Berk.) Sacc. colonizes in Stroma on Hepialidae insect larvae and larva cadaveric complex.Early summer Stroma is unearthed, spore takes when not dispersing, and shines to 6 seventy percent dry, removes quasi-fibrous attachment and impurity, dry or cold drying.Nature and flavor: sweet are flat.Gui Jing: return lung, kidney channel.Cure mainly: invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough dyspnea due to deficiency, chronic cough is spat blood, impotence and seminal emission, soreness of waist and knee joint.

Radix Crepidis elongatae: source: " the southern regions of the Yunnan Province book on Chinese herbal medicine ".Nature and flavor: 1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature flat, sweet in the mouth." 2. " mountain of papers Chinese herbal medicine ": " is bitter, temperature." cure mainly: kidney-replenishing, replenishing QI and blood, strengthening the spleen and stomach.Control sexual neurasthenie, married woman's cold womb is infertile, and leucorrhea is leaked down, dizziness and tinnitus, nervous palpitation with a distress feeling, digestant for baby and malnutrition.

Rhizoma Alismatis: source: " herbal classic ".Nature and flavor: sweet, cold.1. " herbal classic ": " sweet in the mouth, cold." 2. " not Lu ": " be salty, nontoxic." 9. " property of medicine opinion ": " bitter in the mouth." 4. " medicine origin ": " gas is put down, sweet in the mouth." return through: enter kidney, urinary bladder channel.Cure mainly: diuretic, eliminating dampness by diuresis, expel the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.

Cortex Magnoliae Officinalis: nature and flavor: toil, temperature.1. " herbal classic ": " bitter in the mouth, temperature." 2. " not Lu ": " temperature greatly, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is pungent, too hot." return through: enter spleen, stomach, large intestine channel.Cure mainly: warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant.Control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.1. " herbal classic ": " cold and heat are palpitated with fear, and QI and blood numbness, dead flesh, goes three worms for main apoplexy typhoid fever, headache." 2. " not Lu ": " warming middle-JIAO QI invigorating, the expectorant therapeutic method to keep the adverse QI flowing downwards.Treat cholera and stomachache distension, cold in the stomach is inverse and vomit more than in the heart, lets out dysentery and drenches dew, except frightened, and earnest stuffy sensation with restlessness of going or staying, thick the intestines and stomach." 3. " property of medicine opinion ": " main treatment cold air for many years, thunderous in abdomen, void is shouted, and dyspepsia does not disappear, and except phlegm retention, goes to bear water, and broken stagnated blood, disappear digesting and absorbing the essence of foodstuff, pain relieving.Large stomach warming gas, acid regurgitation.Main fullness in the chest and abdomen, the empty and greasy urine of patient." 4. " Japan hanako materia medica ": " spleen invigorating.Main regurgitation, cramp caused by acute vomiting and diarrhea, cold and hot gas, rushes down bladder, lets out all gas of five Tibetan, and married woman's abdomen in antenatal puerperal is hidden uneasy.Adjust joint, kill abdomen and hide worm, improve visual and auditory acuity." 5. Wang Haogu: " main lung qi distension, swollen and breath with cough." 6. " book on Chinese herbal medicine is just ": " temperature drop, loose stagnant, eliminating cold-damp dysentery."

Fructus cari carvi: source: " illustrated handbook planted by middle traditional Chinese medicines ".Another name: tribute cattle, Guo bird (Tibetan name).Source: be the fruit of samphire Fen Artemisia.Picking fruit or extract Herb, dried, laid seed, decontamination autumn.Nature and flavor: 1. " Chinese herbal medicine is commonly used in Tibet ": " warm in nature, taste is micro-pungent." " plateau Chinese herbal treatment handbook ": " is warm in nature, and sweet in the mouth is pungent." return through: " plateau Chinese herbal treatment handbook ": " enters kidney, stomach warp." curing mainly: 1. " Chinese herbal medicine is commonly used in Tibet ": " fragrant stomach invigorating, wind dispelling is regulated the flow of vital energy and is treated for stomachache, stomachache, inguinal hernia." 2. " plateau Chinese herbal treatment handbook ": " wind dispelling method is trembled with fear, spleen benefiting and stimulating the appetite.Control cold stagnant lumbago, cold syndrome of the stomach vomiting."

Placenta Hominis: another name: Placenta Hominis, afterbirth, afterbirth.Source: this product is the dry Placenta Hominis of Healthy People.Fresh human placenta being removed amniotic membrane and umbilical cord, repeatedly rinsing to removing blood, after steaming or putting and slightly boil in boiling water, dry.Nature and flavor: sweet, salty, temperature.Gui Jing: GUIXIN, lung, kidney channel.Cure mainly: the kidney warming mends essence, benefiting QI and nourishing blood.For asthenia weakness and emaciation, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.

Rhizoma Cyperi: another name: dried tuber, Rhizoma Cyperi, Thunder God head, Herba Caricis Phacotae, fragrant head grass, later blue or green, passeris montani saturati head perfume.Source: this product is the dry rhizome of sedge dried tuber Cyperus rotundus L..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry, or burn and directly to dry afterwards.Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Gui Jing: return liver, spleen, tri-jiao channel.Cure mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Semen vignae sinensis: source: herbal for Relief of Famines.Another name: Cornu Caprae seu Ovis, fresh kidney beans (" medical center bun is wanted "), angle bean, rice bean, waist bean, long bean, opotism bean (" Chinese main plant figure says pulse family "), slurry bean (" Guizhou side's medicine among the people collection ").Source: be the seed of leguminous plant Semen vignae sinensis.Autumn gathers after fruit maturation.Nature and flavor: sweet are flat.Gui Jing: enter spleen, kidney channel.Cure mainly: strengthening spleen, tonifying kidney.Control weakness of the spleen and stomach, dysentery, tell inverse, quench one's thirst, seminal emission, leucorrhea, nebulousurine, frequent micturition." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control spleen soil weak, appetite promoting and the spleen strengthening.QI invigorating in " " detailed outline ": " reason, tonifying kidney and promoting digestion, and the five internal organs, adjust battalion to defend, spermatogenesis marrow.Only quench one's thirst, tell inverse, let out dysentery, frequent micturition, separate the big poison of Mus." " Bencao Congxin ": " loose blood detumescence, heat-clearing and toxic substances removing." " medical center bun is wanted ": " reinforcing the heart rushes down kidney, infiltration, diuresis, the turbid descending the lucid yang sending up." " Traditional Chinese Medicine in Sichuan will ": " enriching yin and nourishing kidney, strengthening the spleen and stomach, helps digestion.Control dyspeptic abdominal distention, leucorrhea, nebulousurine and emission due to deficiency of the kidney."

Actinolitum: another name: Bai Shi, Shi Sheng.Source: be asbestos Ore.The whole year can adopt, and after digging out, removes earth and assorted stone.Nature and flavor: salty, tepor.Cure mainly: the kidney invigorating, tonifying YANG.For sexual impotence erectile problem, the cold numbness of waist knee joint, limbs are fainted cold, uterus cold caused by deficiency, menoxenia.

Penis et testis cervi: another name: Penis et testis cervi, Lu Chong.Source: be penis and the testis part of deer.The pudendum of deer is cut off the residual meat of rear removing and oils and fats is air-dry forms.Nature and flavor: sweet are flat.Cure mainly: kidney invigorating and YANG supporting, stimulating milk secretion.For suffering from a deficiency of the kidney, sexual neurasthenie, seminal emission, spermatorrhea, hypogalactia.

Herba Crotalariae Ferrugineae: source: " the southern regions of the Yunnan Province book on Chinese herbal medicine ".Another name: Herba cassiae torae (" Chinese Plants will "), lotus pigweed, Hemerocallis citrina Baroni Herba Crotalariae sessiliflorae (" Chinese main plant figure says pulse family "), horse jingle bell (" the southern regions of the Yunnan Province book on Chinese herbal medicine arranges this "), bell bell grass, kidney qi careless (" Traditional Chinese Medicine in Sichuan will "), jingle bell (" illustrated handbook planted by middle traditional Chinese medicines "), doggie jingle bell, Herba pycnosporae lutescentis, jingle bell, vetch, Ma little Lian, wild green soyabeans (" choosing of Yunnan Chinese herbal medicine "), Ma Lingcao, loud grass, lotus hold grass (Jiangxi " medical herbs handbook ").Source: the herb blue for the false ground of leguminous plant or whole herb with root.Summer gathers, and dries, or cutting is dried.Nature and flavor: bitter micro-acid, cold.Gui Jing: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter lung." cure mainly: gas of astringing the lung, spleen reinforcing kidney, diuresis, detumescence poison.Control chronic cough expectorant blood, tinnitus, deaf, nocturnal emission, chronic nephritis, cystitis, renal calculus, tonsillitis, lymphadenitis, furunculosis, malignant boil." vegetation is side just ": " invigorating the spleen and replenishing QI, treat tinnitus, the head is giddy, collapses pouring.Pathogenic fire purging heat clearing away again, suppressing liver-wind, detumescence pain." " classifying herbal ": " large spleen reinforcing kidney, controls deafness, the deficiency of vital energy." " Traditional Chinese Medicine in Sichuan will ": " invigorating the spleen and replenishing QI, controls Hiccough and deaf, the vertigo, and deficiency of the kidney is passed out semen, and women's emaciation due to chronic blood stasis." " choosing of Yunnan Chinese herbal medicine ": " diuretic, antiinflammatory, relievings asthma, cough-relieving.Control chronic nephritis, cystitis, chronic bronchitis, tonsillitis, lymphadenitis, renal calculus; Menoxenia, dysmenorrhea." Jiangxi " medical herbs handbook ": " removing toxic substances rash."

Radix Mirabilis himalaicae: source: Nyctaginaceae Radix Mirabilis himalaicae Mirabilis himalaica (Edgew.), Heim., is used as medicine with root.Nature and flavor: acrid, sweet, warm.Cure mainly: invigorating spleen and kidney, diuretic.Cure mainly oedema due to nephritis, the diseases such as gonorrhea.

Radix Aconiti Lateralis Preparata: pungent, sweet is warm greatly; Poisonous.GUIXIN, kidney, spleen channel.For " recuperating depleted YANG and rescuing the patient from collapse first product medicine " has recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by effect of wind-cold damp pathogen.For excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhoea, it is inverse to faint, cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, and deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.Gas hero row is loose, can rise and can fall, walk and do not keep." book on Chinese herbal medicine converges and says " cloud: " Radix Aconiti Lateralis Preparata, recuperating depleted YANG gas, loose YIN-cold.The time of all genus yang deficiency negative electrodes, lung nephrons heat syndrome person, clothes had dead distinguished service." Materia Medica of Decoction: " taking pulse lightly, moderately and heavily, penetrates everywhere, the large heat of acrid in the mouth, is the yang aspect of yang for Radix Aconiti Lateralis Preparata, the agent of few positive three burnt, gate of vitality that starts with, therefore row and more than, non-some Rhizoma Zingiberis Recens are only also not all right.Body table cool and four cold of the limbs persons overstep the authority use, as with person with its arresting the unfavorable development of disease also." Shennong's Herbal: " main air is trembled with fear cough with dyspnea pathogen, warming middle-JIAO, incised wound, and broken disease heavily fortified point gathers, abdominal mass due to blood stasis, cold-damp, contracture gonalgia, can not go step." be that " recuperating depleted YANG and rescuing the patient from collapse first product medicine " has recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by effect of wind-cold damp pathogen.For excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhoea, it is inverse to faint, cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, and deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.And Radix Aconiti Lateralis Preparata is to hypophysis---interrenal system has excitation, can also excited vagus and tool cardiotonic.

Fructus Corni: sour, puckery, tepor; Enter liver, the heart, kidney three warp.Invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse." Mingyi Bielu " carries: " Fructus Corni tepor, nontoxic.Cure mainly the intestines and stomach ailment said due to cold or exposure, cold and heat hernia abdominal mass ... deafness, the therapeutic method to keep the adverse QI flowing downwards, perspires, benefit essence, settling five organs, logical nine orifices, only normal urination." Materia Medica of Decoction: " and sliding then QI prostration, astringent is so receive it, and Fructus Corni stops normal urination, secret vital essence get its sour-puckery flavor with receive sliding also." invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.

Fructus Lycii: sweet is flat.Folium Lycii: bitter, sweet; Cool in nature.Enter liver, kidney, lung meridian.Control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand." Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." effect such as lycium barbarum polysaccharide has Promote immunity, defying age, antitumor, scavenging free radicals, resisting fatigue, radioprotective, protects the liver, reproductive function protection and improvement.Carotene is the main active of wolfberry pigment, has antioxidation and as the important physiological function of the synthesis precursor etc. of vitamin A.Mouse gavaging Fructus Lycii water extract or intramuscular injection alcohol extract and lycium barbarum polysaccharide, the phagocytic function of the macrophage that is improved, strengthens the effect of serum lysozyme, improves tiring of anti-sheep red blood cell (SRBC) antibody in serum.Wolfberry fruit extract significantly and lastingly can reduce rat blood sugar, increase carbohydrate tolerance, and toxicity is less.

Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat, nontoxic.Return Liver and kidney warp.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion." not Lu ": " support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending." " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary." the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Semen Cuscutae is improved the effect of fruit bat Sexual potency, and its mating rate is obviously increased, and its effect is strong and weak becomes positive correlation with administration concentration.Preserved material, to anesthetized dog intravenous injection, has the effect making blood pressure drops." must book on Chinese herbal medicine be joined ": " anemia of pregnant woman, metrorrhagia, postcoital protrusion, constipation, kidney have fire, deficiency of YIN fire dynamic, six forbiddings.”

Colla cornus cervi: nature and flavor: Gan Xian, temperature.Gui Jing: enter liver, kidney channel.Function cures mainly: enrich blood, benefit essence.Control deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.1. " herbal classic ": " main damaging the spleen and stomach labor is exhausted; Lumbago weakness and emaciation, invigorating the spleen and replenishing QI, married woman's blood closes loss of fecundity, and pain relieving is antiabortive." 2. " not Lu ": " be treated and is spitted blood, hematochezia, and metrorrhagia is more than, painful limbs, hyperhidrosis, drenches dew, and folding gets injured by a fall damage." 3. " property of medicine opinion ": " main man's kidney is hidden weakness of QI asthenia and is contributed, and antiabortively can go cold, control whitish metrorrhagia, main haematemesis." 4. " Elementary Medicine ": " main cough, spits blood, spitting of blood, hemoptysis, hematuria, hematochezia." 5. " detailed outline ": " controls chronic cough, urine essence, hematuria, sore swollen toxin." 6. " beautiful Chinese catalpa medicine solution ": " warming the liver the kidney invigorating, grows benefiting essence-blood.Control sexual impotence essence sliding, traumatic injury." 7. " Jilin Chinese herbal medicine ": " supplementing the brain, heart tonifying.Control cerebral edema."

Poria cum Radix Pini: sweet, light; GUIXIN, spleen channel.Function mind calming, calm the nerves, diuretic.For palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria." property of medicine opinion ": " main infantile convulsion, tranquilizing the mind are mended tired; Main acute pain in the epigastrium heavily fortified point is full, and small intestinal is unfavorable." " medicineization justice ": " Poria cum Radix Pini, its body is heavy, mental disorder may be cured with heavy sedatives, its benefit warm in nature, drugs with tonic function being used for the debility." function mind calming, calm the nerves, diuretic.For palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.Laboratory animal, with after Poria cum Radix Pini 10-20g/kg gavage, enters quiet sleepy state, but without sleep phenomenon; For the mice of caffeine sodium benzoate excitement, make lumbar injection with Poria cum Radix Pini's decoct 5g/kg, it can be made calm, and calm rate is 90%, calm index 3.11; If use 20g/kg gavage instead, then calm rate is 85.7%, calm index 1.64.

Radix Polygalae: bitter, pungent, tepor; GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Shennong's Herbal: ", except pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight, does not forget, strong will times power for main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency." " Japan hanako materia medica ": " the frightened black mole of main diaphragm gas, longue meat, helps muscles and bones, and married woman's blood is kept silent aphonia, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.

Semen Ziziphi Spinosae: sweet, sour, property is put down.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.Nourishing the liver, mind calming, calms the nerves, arresting sweating.Shennong's Herbal: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." " property of medicine opinion ": " main muscles and bones wind is fried end and is taken it as soup.

Arillus Longan: sweet, temperature.GUIXIN, spleen channel.Nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " nourishing blood to tranquillize the mind, long intelligence arresting sweating, appetizing strengthening the spleen." " Quanzhou book on Chinese herbal medicine ": " tonifying YANG QI invigorating, tonifying the spleen and stomach.Control married woman's puerperal edema, deficiency of vital energy edema, diarrhea due to hypofunction of the spleen.Invigorating the heart and spleen, " nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.

Ganoderma: the Ganoderma that Ganoderma makes medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma, and its property of medicine is sweet, flat.GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Zoopery and clinical trial all show, Ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.Polysaccharide contained by Ganoderma, polypeptide etc. have obvious function of delaying senility.Extract energy exciting motion suppresses, mobility is reduced, coordination exercise is lacked of proper care, presents the sick effect in dose-dependent town, can curtail sleep to hexobarbital sleep effect, the time that central stimulants caffeine causes spasm and death can be extended, these results show, Ganoderma is inhibition effect to maincenter.

Radix Polygoni Multiflori: bitter, sweet, puckery, tepor; Return liver, kidney channel.Can detoxify, eliminating carbuncle, loosening bowel to relieve constipation.Cure mainly Liver and kidney asthenia of essence and blood, soreness of the waist and knees, seminal emission tinnitus, has a dizzy spell, palpitation and insomnia, early whitening of beard and hair, the dry constipation of spleen, rubella tinea scabies, skin pruritus, malaria, scrofula, temperament wind, hemorrhoid, carbuncle sore." book on Chinese herbal medicine converges and says ": " have micro-poison.Enter to lead in liver, close in wind outward, rise also, sun also." " Kaibao Bencao ": " originally go out along Nanhe River county, state, outside modern ridge, south of the River Zhu Zhou all has.Climing purple, in vain brightly yellowish, leaf as Rhizoma Dioscoreae not only.Life must be relative, and root is large has red, white two kinds as fist, and red person is male, and white person is female ... spring, Xia Cai." can detoxify, eliminating carbuncle, loosening bowel to relieve constipation.Cure mainly Liver and kidney asthenia of essence and blood, soreness of the waist and knees, seminal emission tinnitus, has a dizzy spell, palpitation and insomnia, early whitening of beard and hair, the dry constipation of spleen, rubella tinea scabies, skin pruritus, malaria, scrofula, temperament wind, hemorrhoid, carbuncle sore.Have promotion hemopoietic function, strengthen immunologic function, blood fat reducing and atherosclerosis, protect the liver, and Radix Polygoni Multiflori contains the effective ingredient such as chrysophanol, emodin, chrysophanic acid, physcione, fatty oil, starch, saccharide, rhaponticin, lecithin.Pharmacological research proves, Radix Polygoni Multiflori can promote the conversion of human lymphoblastoid cell.Still there is effects such as reducing serum cholesterol, arteriosclerosis, anti-light poison.

Herba Agrimoniae: bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel, astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache in face, with the passing of time red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage card.

Herba Pyrolae: have another name called Herba pyrolae japonicae.Sweetness and bitterness, temperature.Enter lung meridian, stomach warp, Liver Channel, kidney channel." Zhiwu Mingshi Tukao ": " control haematemesis, stimulate the menstrual flow, strong muscle, strong bone, mends waist kidney, born fluid." can tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation, the kidney invigorating bone strengthening, expelling wind and removing dampness, cough-relieving, hemostasis.Main lumbago due to renal deficiency, rheumatic arthralgia, soft, the new chronic cough of muscles and bones flaccidity are coughed, spit blood, epistaxis, metrorrhagia, traumatic hemorrhage.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.The sweet A of Radix Et Caulis Acanthopanacis Senticosi is carotene, also containing this constituents in people Ginseng.The excretion of cholesterol can be promoted in human body, the too high disease of blood cholesterol level can be prevented and treated.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to Ren Ginseng Saponin.

Rhizoma Cibotii: bitter, sweet, temperature.Return liver, kidney channel.Function wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint." Mingyi Bielu ": " treatment is lost to drown and do not saved, man's flaccidity of the lower limbs lumbago, and ailment said due to cold or exposure drenches dew, weak breath order Dark, hard ridge, sharp pitching, woman's damaging the spleen and stomach, and joint weighs." " property of medicine opinion ": " control man woman poison wind weak foot, pathogen arthralgia chiefly caused by damp pathogen, kidney qi is weak, tonification man, stricture of vagina muscles and bones." function wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.Cure mainly rheumatic arthralgia, soreness of the waist and knees, weakness of the lower extremities, frequent micturition, the enuresis, leukorrhagia.

Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, return kidney, spleen channel.Kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for the treatment of impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition, the Diarrhoea that deficiency of spleen-YANG and kidneyYANG causes.The deficiency and coldness of failure of the kidney in receiving QI is breathed with cough." property of medicine opinion ": " main man's pain in the lumbar region, the cold capsule of knee joint wets, stupid by all cold numbness, and only normal urination, cold in abdomen." " Kaibao Bencao ": " bone marrow wound loses for main five kinds of strain and seven kinds of impairment, wind cold caused by deficiency, the cold essence stream of kidney and the induced abortion of married woman's vim and vigour." kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for the treatment of impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition, the Diarrhoea that deficiency of spleen-YANG and kidneyYANG causes.The deficiency and coldness of failure of the kidney in receiving QI is breathed with cough.Act on the contiguous destruction not yet completely of damaged cell or normal melanocyte after medication, tyrosinase activity is increased, promotes melanin genesis.Fructus Psoraleae has obvious diastole effect to the airway constriction caused by histamine, the strongest with effect in 15 minutes after dosing, but is slightly inferior to aminophylline, two groups compared with blank group spasmolysis, difference highly significant.

Embodiment 1 granule

The manufacturing process of granule of the present invention is: get Radix Aconiti Lateralis Preparata 150g, Radix Mirabilis himalaicae 300g, Fructus Corni 220g, Herba Crotalariae Ferrugineae 300g, Fructus Lycii 400g, Penis et testis cervi 220g, Semen Cuscutae 250g, Actinolitum 350g, Semen vignae sinensis 150g, Herba balanophorae japonicae 320g, Poria cum Radix Pini 220g, Herba Pyrolae 320g, Rhizoma Cyperi 150g, milk 350g, Radix Polygalae 220g, Placenta Hominis 150g, Semen Ziziphi Spinosae 350g, Fructus cari carvi 140g, Arillus Longan 220g, Cortex Magnoliae Officinalis 330g, Ganoderma 250g, Rhizoma Alismatis 300g, Cornu Cervi Degelatinatum 200g, Radix Polygoni Multiflori 120g, Radix Crepidis elongatae 320g, Colla Corii Asini 200g, Cordyceps 400g, pick up the ears 150g and Herba Agrimoniae 300g,

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 7 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.04, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Embodiment 2 tablet

The manufacturing process of Tablets is: get Radix Aconiti Lateralis Preparata 200g, Radix Mirabilis himalaicae 150g, Fructus Corni 220g, Herba Crotalariae Ferrugineae 300g, Fructus Lycii 200g, Penis et testis cervi 310g, Semen Cuscutae 300g, Actinolitum 250g, Semen vignae sinensis 200g, Herba balanophorae japonicae 150g, Poria cum Radix Pini 240g, Herba Pyrolae 150g, Rhizoma Cyperi 220g, milk 350g, Radix Polygalae 150g, Placenta Hominis 200g, Semen Ziziphi Spinosae 350g, Fructus cari carvi 150g, Arillus Longan 300g, Cortex Magnoliae Officinalis 330g, Ganoderma 220g, Rhizoma Alismatis 300g, Cornu Cervi Degelatinatum 250g, Radix Polygoni Multiflori 100g, Radix Crepidis elongatae 320g, Colla Corii Asini 140g, Cordyceps 420g, pick up the ears 200g and Herba Agrimoniae 350g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 3 hours, pulverize, sieve, obtain 500 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.1 times, 0.15 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.035 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 3 oral liquid

The manufacturing process of oral liquid of the present invention is: get Radix Aconiti Lateralis Preparata 120g, Radix Mirabilis himalaicae 250g, Fructus Corni 200g, Herba Crotalariae Ferrugineae 300g, Fructus Lycii 400g, Penis et testis cervi 140g, Semen Cuscutae 250g, Actinolitum 350g, Semen vignae sinensis 120g, Herba balanophorae japonicae 300g, Poria cum Radix Pini 220g, Herba Pyrolae 320g, Rhizoma Cyperi 200g, milk 350g, Radix Polygalae 220g, Placenta Hominis 150g, Semen Ziziphi Spinosae 250g, Fructus cari carvi 140g, Arillus Longan 300g, Cortex Magnoliae Officinalis 250g, Ganoderma 170g, Rhizoma Alismatis 300g, Cornu Cervi Degelatinatum 140g, Radix Polygoni Multiflori 130g, Radix Crepidis elongatae 300g, Colla Corii Asini 150g, Cordyceps 350g, pick up the ears 200g, Herba Agrimoniae 350g, Cauda cervi 140g, Fructus Hordei nudi Germinatus 320g, Radix Et Caulis Acanthopanacis Senticosi 220g, Fructus Alpiniae Oxyphyllae 140g, Rhizoma Cibotii 320g, Cortex Eucommiae 220g and Fructus Psoraleae 250g,

The first step, by Cordyceps, pick up the ears, Herba Agrimoniae, Cauda cervi, Fructus Hordei nudi Germinatus, Radix Et Caulis Acanthopanacis Senticosi, Fructus Alpiniae Oxyphyllae, Rhizoma Cibotii, the Cortex Eucommiae and Fructus Psoraleae mixing, add relative to mixture 8 times amount determining alcohol be 90% alcohol reflux 3 times, each 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.38, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 7 times of water gagings, boils 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.35;

3rd step, the described mastic mixing that the first step, second step are obtained, 75 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, dealcoholation treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 45 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 70 ~ 90 minutes, and temperature is 170 DEG C;

Acute toxicity test: application NIH mice 40, S recovery from illness F level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 2 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 3 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: the 308 routine patients selecting in July, 2012 to 2013 year outpatient service in July or be in hospital, male or female, man 217 example, female 91 example, age 45-70 year, average (65.2 ± 4.5) year, the course of disease 5 months to 1 year half, average 15.5 months; 308 routine patients meet following condition: get rid of the caused Secondary cases O P such as hyperparathyroidism, multiple myeloma, prolonged application glucocorticoid; Within nearly 3 months, do not use and affect bone metabolism medicine, as vitamin D, estrogen, calcium preparation, diphosphate etc.; Without severe cardiac, liver, nephropathy.Diagnostic criteria adopts 1999 " Chinese's osteoporosis suggestion diagnostic criteria (the second original text) "; Granules in Treating group, tablet in treatment group, oral liquid treatment group and matched group are divided at random to 308 routine patients, each experimental group 77 people.

Diagnostic criteria: with reference to " Chinese's osteoporosis suggestion diagnostic criteria (the second original text) ", must possess overall pain, be that obviously microtrauma can cause fracture mainly with lumbar and back pain, or scheuermann kyphosis deformity, or bone density (BMD) reduces by 2 above persons of standard deviation.

1. inclusive criteria has typical OP clinical symptoms, meets OP diagnostic criteria; 2. age person between 45-70 year; 3. voluntary as study subject, signature Informed Consent Form, and energy reception test pharmaceutical dosage form, ensured person's course for the treatment of.

1. exclusion standard has secondary osteoporosis and other serious complication persons such as hyperparathyroidism, osteomalacia, rheumatoid arthritis, multiple myeloma; 2. obviously bow-backed deformity, disabled and disability person is presented; 3. severe cardiac cerebrovascular is suffered from, liver, kidney, lung and hemopoietic system primary disease person; 4. within the observation period course for the treatment of, due to a variety of causes, as gone out, residence migration etc. can not obtain the person of following up a case by regular visits on request; 5. to this drug allergy person or to multi-medicament allergy sufferers; 6. psychosis or patients with Alzheimer disease; 7. duration of test is failed by regulation medication or the person of dropping by the wayside.

Therapeutic Method:

In medication therapy groups:

Granules in Treating group: use the embodiment of the present invention 1 to prepare granule, every day 3 times, once a bag, every bag of 6g every 30 days is 1 course for the treatment of;

Tablet in treatment group: take the embodiment of the present invention 2 prepare tablet, every day 3 times, one time 2, within every 30 days, be a course for the treatment of;

Oral liquid treatment group: use oral liquid prepared by the embodiment of the present invention 3, every day 3 times, 30ml/ time every 30 days is a course for the treatment of.

Matched group: take XIANLING GUBAO PIAN, every day 3 times, one time 2, within every 30 days, be a course for the treatment of.

The standard of curative effect evaluation: according to " new Chinese medicine guideline of clinical investigations " Beijing: China Medical Science Press, author: Zheng Xiao cornel; Formulate criterion of therapeutical effect.Effective: pain disappears completely, BMD checks that display bone density increases; Effective: pain is obviously alleviated, BMD checks that having no bone density declines; Invalid: to compare with before treatment, each side is all without improvement.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy osteoporosis of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy matter of the present invention loosen, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Table 2 Four composition is effective and efficiently individual quantity time comparative example (%) after not treating 4 courses for the treatment of

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; 229 example and the effective and effective 69 routine follow-up of patients 1 year half of matched group of and efficiently individual quantity effective to treatment group simultaneously, result is added up, and in Granules in Treating group 76 example, effective 74 examples are without recurring, and without 1 case relapsed in effective 2 examples, relapse rate is 1.3%; In tablet in treatment group 76 example, effective 72 examples are without recurrence, 1 case relapsed in effective 4 examples, and relapse rate is 1.3%; In oral liquid treatment group 77 example effective 76 example and effective 1 example in all without recur, relapse rate is 0%; Matched group is effective and efficiently individual quantity 69 routine, recurs 7 examples in effective 55 routine patients, recurs 9 examples, relapse rate 23.2% in effective 14 routine patients; Above-mentioned recurrence refer to patient outcomes reach effective or effectively after, in 1 year half of following up a case by regular visits to, obviously there is the symptom before treatment.

Model case: Wang, male, 67 years old, encounter marble bone because of wrist and fold into institute, have dizziness, tinnitus, Mental fatigue is sleepy, night frequent micturition, soreness of the waist and knees is unable, large loose stool, the symptoms such as light red tongue, x-ray inspection: tubular bone cortex is thinning, pulp cavity broadens, bone trabecula decreased number, its gap is also broadening, is diagnosed as osteoporosis.Take the oral liquid of Medications Example 3 of the present invention, every day 3 times, 30ml/ time, medication is cured a course for the treatment of substantially, continues medication two weeks and cures, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of osteoporosis for one kind, it is characterized in that, comprise following raw medicinal material: Radix Aconiti Lateralis Preparata, Radix Mirabilis himalaicae, Fructus Corni, Herba Crotalariae Ferrugineae, Fructus Lycii, Penis et testis cervi, Semen Cuscutae, Actinolitum, Semen vignae sinensis, Herba balanophorae japonicae, Poria cum Radix Pini, Herba Pyrolae, Rhizoma Cyperi, milk, Radix Polygalae, Placenta Hominis, Semen Ziziphi Spinosae, Fructus cari carvi, Arillus Longan, Cortex Magnoliae Officinalis, Ganoderma, Rhizoma Alismatis, Cornu Cervi Degelatinatum, Radix Polygoni Multiflori, Radix Crepidis elongatae, Colla Corii Asini, Cordyceps, to pick up the ears and Herba Agrimoniae.

2. the medicine for the treatment of osteoporosis according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 10 ~ 22 parts, Radix Mirabilis himalaicae 15 ~ 35 parts, Fructus Corni 10 ~ 25 parts, Herba Crotalariae Ferrugineae 12 ~ 32 parts, Fructus Lycii 15 ~ 40 parts, Penis et testis cervi 11 ~ 31 parts, Semen Cuscutae 10 ~ 30 parts, Actinolitum 20 ~ 40 parts, Semen vignae sinensis 7 ~ 20 parts, Herba balanophorae japonicae 14 ~ 34 parts, Poria cum Radix Pini 12 ~ 22 parts, Herba Pyrolae 13 ~ 33 parts, Rhizoma Cyperi 12 ~ 24 parts, milk 16 ~ 38 parts, Radix Polygalae 14 ~ 24 parts, Placenta Hominis 10 ~ 20 parts, Semen Ziziphi Spinosae 15 ~ 35 parts, Fructus cari carvi 10 ~ 20 parts, Arillus Longan 11 ~ 31 parts, Cortex Magnoliae Officinalis 14 ~ 36 parts, Ganoderma 15 ~ 25 parts, Rhizoma Alismatis 12 ~ 32 parts, Cornu Cervi Degelatinatum 12 ~ 26 parts, Radix Polygoni Multiflori 7 ~ 15 parts, Radix Crepidis elongatae 12 ~ 32 parts, 10 ~ 20 parts, Colla Corii Asini, Cordyceps 20 ~ 45 parts, to pick up the ears 12 ~ 22 parts and Herba Agrimoniae 15 ~ 35 parts.

3. the medicine for the treatment of osteoporosis according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 12 ~ 20 parts, Radix Mirabilis himalaicae 15 ~ 30 parts, Fructus Corni 15 ~ 22 parts, Herba Crotalariae Ferrugineae 14 ~ 30 parts, Fructus Lycii 15 ~ 40 parts, Penis et testis cervi 12 ~ 31 parts, Semen Cuscutae 15 ~ 30 parts, Actinolitum 25 ~ 40 parts, Semen vignae sinensis 10 ~ 20 parts, Herba balanophorae japonicae 15 ~ 35 parts, Poria cum Radix Pini 14 ~ 24 parts, Herba Pyrolae 15 ~ 32 parts, Rhizoma Cyperi 14 ~ 22 parts, milk 18 ~ 36 parts, Radix Polygalae 15 ~ 24 parts, Placenta Hominis 12 ~ 20 parts, Semen Ziziphi Spinosae 15 ~ 35 parts, Fructus cari carvi 14 ~ 20 parts, Arillus Longan 12 ~ 30 parts, Cortex Magnoliae Officinalis 15 ~ 35 parts, Ganoderma 15 ~ 25 parts, Rhizoma Alismatis 14 ~ 30 parts, Cornu Cervi Degelatinatum 14 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Radix Crepidis elongatae 14 ~ 32 parts, 12 ~ 20 parts, Colla Corii Asini, Cordyceps 20 ~ 42 parts, pick up the ears 14 ~ 20 parts, Herba Agrimoniae 15 ~ 35 parts.

4. the medicine of the treatment osteoporosis according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 15 parts, Radix Mirabilis himalaicae 30 parts, Fructus Corni 22 parts, Herba Crotalariae Ferrugineae 30 parts, Fructus Lycii 40 parts, Penis et testis cervi 22 parts, Semen Cuscutae 25 parts, Actinolitum 35 parts, Semen vignae sinensis 15 parts, Herba balanophorae japonicae 32 parts, Poria cum Radix Pini 22 parts, Herba Pyrolae 32 parts, Rhizoma Cyperi 15 parts, milk 35 parts, Radix Polygalae 22 parts, Placenta Hominis 15 parts, Semen Ziziphi Spinosae 35 parts, Fructus cari carvi 14 parts, Arillus Longan 22 parts, Cortex Magnoliae Officinalis 33 parts, Ganoderma 25 parts, Rhizoma Alismatis 30 parts, Cornu Cervi Degelatinatum 20 parts, Radix Polygoni Multiflori 12 parts, Radix Crepidis elongatae 32 parts, 20 parts, Colla Corii Asini, Cordyceps 40 parts, to pick up the ears 15 parts and Herba Agrimoniae 30 parts.

5. the medicine of the treatment osteoporosis according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 20 parts, Radix Mirabilis himalaicae 15 parts, Fructus Corni 22 parts, Herba Crotalariae Ferrugineae 30 parts, Fructus Lycii 20 parts, Penis et testis cervi 31 parts, Semen Cuscutae 30 parts, Actinolitum 25 parts, Semen vignae sinensis 20 parts, Herba balanophorae japonicae 15 parts, Poria cum Radix Pini 24 parts, Herba Pyrolae 15 parts, Rhizoma Cyperi 22 parts, milk 35 parts, Radix Polygalae 15 parts, Placenta Hominis 20 parts, Semen Ziziphi Spinosae 35 parts, Fructus cari carvi 15 parts, Arillus Longan 30 parts, Cortex Magnoliae Officinalis 33 parts, Ganoderma 22 parts, Rhizoma Alismatis 30 parts, Cornu Cervi Degelatinatum 25 parts, Radix Polygoni Multiflori 10 parts, Radix Crepidis elongatae 32 parts, 14 parts, Colla Corii Asini, Cordyceps 42 parts, to pick up the ears 20 parts and Herba Agrimoniae 35 parts.

6. the medicine of the treatment osteoporosis according to any one of claim 1-5, is characterized in that, in described medicine, each raw medicinal material also comprises: Cauda cervi, Fructus Hordei nudi Germinatus, Radix Et Caulis Acanthopanacis Senticosi, Fructus Alpiniae Oxyphyllae, Rhizoma Cibotii, the Cortex Eucommiae and Fructus Psoraleae.

7. the medicine of the treatment osteoporosis according to any one of claim 1-6, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 12 ~ 20 parts, Radix Mirabilis himalaicae 15 ~ 30 parts, Fructus Corni 15 ~ 22 parts, Herba Crotalariae Ferrugineae 14 ~ 30 parts, Fructus Lycii 15 ~ 40 parts, Penis et testis cervi 12 ~ 31 parts, Semen Cuscutae 15 ~ 30 parts, Actinolitum 25 ~ 40 parts, Semen vignae sinensis 10 ~ 20 parts, Herba balanophorae japonicae 15 ~ 35 parts, Poria cum Radix Pini 14 ~ 24 parts, Herba Pyrolae 15 ~ 32 parts, Rhizoma Cyperi 14 ~ 22 parts, milk 18 ~ 36 parts, Radix Polygalae 15 ~ 24 parts, Placenta Hominis 12 ~ 20 parts, Semen Ziziphi Spinosae 15 ~ 35 parts, Fructus cari carvi 14 ~ 20 parts, Arillus Longan 12 ~ 30 parts, Cortex Magnoliae Officinalis 15 ~ 35 parts, Ganoderma 15 ~ 25 parts, Rhizoma Alismatis 14 ~ 30 parts, Cornu Cervi Degelatinatum 14 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Radix Crepidis elongatae 14 ~ 32 parts, 12 ~ 20 parts, Colla Corii Asini, Cordyceps 20 ~ 42 parts, pick up the ears 14 ~ 20 parts, Herba Agrimoniae 15 ~ 35 parts, Cauda cervi 10 ~ 25 parts, Fructus Hordei nudi Germinatus 10 ~ 32 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 25 parts, Fructus Alpiniae Oxyphyllae 10 ~ 15 parts, Rhizoma Cibotii 20 ~ 35 parts, the Cortex Eucommiae 10 ~ 22 parts and Fructus Psoraleae 10 ~ 30 parts.

8. the medicine of the treatment osteoporosis according to any one of claim 1-7, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Aconiti Lateralis Preparata 12 parts, Radix Mirabilis himalaicae 25 parts, Fructus Corni 20 parts, Herba Crotalariae Ferrugineae 30 parts, Fructus Lycii 40 parts, Penis et testis cervi 14 parts, Semen Cuscutae 25 parts, Actinolitum 35 parts, Semen vignae sinensis 12 parts, Herba balanophorae japonicae 30 parts, Poria cum Radix Pini 22 parts, Herba Pyrolae 32 parts, Rhizoma Cyperi 20 parts, milk 35 parts, Radix Polygalae 22 parts, Placenta Hominis 15 parts, Semen Ziziphi Spinosae 25 parts, Fructus cari carvi 14 parts, Arillus Longan 30 parts, Cortex Magnoliae Officinalis 25 parts, Ganoderma 17 parts, Rhizoma Alismatis 30 parts, Cornu Cervi Degelatinatum 14 parts, Radix Polygoni Multiflori 13 parts, Radix Crepidis elongatae 30 parts, 15 parts, Colla Corii Asini, Cordyceps 35 parts, pick up the ears 20 parts, Herba Agrimoniae 35 parts, Cauda cervi 14 parts, Fructus Hordei nudi Germinatus 32 parts, Radix Et Caulis Acanthopanacis Senticosi 22 parts, Fructus Alpiniae Oxyphyllae 14 parts, Rhizoma Cibotii 32 parts, the Cortex Eucommiae 22 parts and Fructus Psoraleae 25 parts.

9. the preparation method of the medicine of the treatment osteoporosis according to any one of claim 1-8, is characterized in that, described medicine composition dosage form is granule, and its preparation method is:

10. the preparation method of the medicine of the treatment osteoporosis according to any one of claim 1-8, is characterized in that, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps: