CN106420905A - Capsule for increasing bone density and preparation method of capsules - Google Patents

Abstract

The invention relates to a capsule for increasing bone density and a preparation method of the capsules. The capsule comprises a capsule body and filler filling the capsule body, wherein the filler is prepared from the following raw materials in parts by weight: 25 parts of extracts of fortune's drynaria rhizome, 25 parts of eucommia bark extracts, 80 parts of milkvetch root extracts, 70 parts of Kudzuvine root extracts, 180 parts of oyster extracts, 18 parts of starch and 2 parts of magnesium stearate. The capsule strengthens the activity of osteoblasts, promotes production and secretion of bone matrixes and bone mineralization and improves the body immune function; the components are applied compatibly, realize a synergistic effect, improve calcium absorption of human bodies together and increase the bone density; the preparation method is reasonable in process and high in operability and easily realizes large-scale production.

Description

A kind of capsule increasing bone density and preparation method thereof

Technical field

The present invention relates to a kind of medicinal preparation being characterized with soft capsule preparation, more particularly, to a kind of increase bone density Capsule and preparation method thereof.

Background technology

Osteoporosises are osteoporosis, are one group of osteopathia that many reasons cause, and osseous tissue has normal calcification, calcium salt It is in normal rates with substrate, become with the metabolic osteopathy that unit volume inner bone tissues amount is reduced to feature.In most osteoporosises In, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, it is easy to fracture and is characterized.Clinical manifestation is Pain, height shorten, bow-backed, fracture, respiratory function decline etc., are that a kind of bone amount of general reduces and osseous tissue microstructure Change, the fragility of bone increases, the intensity decreases of bone, in the case of hurtless measure or mild trauma, the disease fractured can occur Disease.Diagnosis of osteoporosis is mainly measured and quantitative analyses to the mineral in skeleton in vitro by instrument, that is, measure Bone density is determining whether there is osteoporosises and the order of severity.At present, people mainly take enhancing to take exercise, reinforcement dietetic nutrition enters The methods such as row tonic strengthen calcareous supplement, but due to body due to, equal difficult to reach therapeutic effect.

Therefore, produce one kind effectively to delay and resist bone loss, increase bone density, have no side effect safely, preparation method letter Single capsule of increase bone density and preparation method thereof, has extensive market prospect.

Content of the invention

For the deficiencies in the prior art, the present invention provides one kind effectively to delay and resist bone loss, increase bone density, safety Have no side effect, preparation method simply increases capsule of bone density and preparation method thereof, be used for overcoming of the prior art many Defect.

The technology contents of the present invention are realized in：A kind of increase bone density capsule, include capsule body be filled in Implant in capsule body is made, and described implant is to be prepared from by the raw material of following parts by weight：Rhizoma Drynariae carries Take 25 parts of thing, 25 parts of Cortex Eucommiae extract, 80 parts of Radix Astragali extract, 70 parts of Radix Puerariae extract, 180 parts of Concha Ostreae extract, starch 18 Part, 2 parts of magnesium stearate.

Described capsule body is No. 0 Capsuleses.

A kind of preparation method of the capsule increasing bone density as above, its preparation method is as follows：

1）The raw material of above-mentioned parts by weight is crossed respectively standby after 60 mesh sieves；

2）The raw material of the above-mentioned parts by weight after sieving is placed in mixer and mixes 30 minutes, obtains mixed powder；

3）Using capsule filling machine, above-mentioned mixed powder is filled in capsule body, the capsule body filled is placed in capsule polisher Middle polishing, is screened after polishing, chooses flat capsule, broken capsule, empty pocket and leakage powder capsule；

4）Pass through Aluminium-coating Packer with the PVC board meeting YBB00212005 standard and the aluminium foil meeting YBB00152002 standard To step 3）Capsule after middle screening is wrapped inside dress, the every plate of packing specification 12；

5）Outer package operation mounted box, every box 2 plate will be proceeded to through the packaged capsule of Aluminium-coating Packer, obtain finished product, finished product will be used Co⁶⁰Sterilizing, dosage is 6KGy, extracts inspection, put in storage after the assay was approved after sterilizing.

The present invention has following good effect：The Therapeutic Principle of integrated control osteoporosis of the present invention, according to rigorous Science carry out compatibility, select Rhizoma Drynariae extract, Cortex Eucommiae extract, Radix Astragali extract, Radix Puerariae extract and Concha Ostreae extract For major ingredient, adding starch and magnesium stearate is adjuvant, strengthens osteoblastic activity, promotes generation, secretion and the bone of bone matrix Mineralising, improves body's immunity, each component compatibility application, produces synergism, and the common raising absorption to calcium for the human body increases Bone density.Using capsule preparations, have carry, taking convenience and easily absorb the features such as.Another research through pharmacological toxicology shows, this Bright compositionss safe without toxic side effect, the effect of be improved bone density.The present invention is with strong points, effect is obvious, is a kind of safety Reliability, the health food of the increase bone density of salubrity body, defying age.The preparation method rational technology of the present invention, workable, Easily accomplish scale production.

Rhizoma Drynariae, nature and flavor are bitter, temperature.Another name：Precipice Rhizoma Zingiberis Recens, rock connect Rhizoma Zingiberis Recens, delevay drynaria, the broken benefit of meat, the broken benefit of stone, flying apsaras Mus, Niu Feilong, Sudden wind, moth grass.Polypodiales, Davalliaceae pteridophyta, whole year all can excavate, and removes silt, be dried, or burn remove floss again （Scale）.This product is in flat strip, bends more, has branch, the close ramentum by dark-brown to burgundy in surface, and softness is such as Hair, is in sepia or crineous through the fire person of burning, and both sides and upper surface all have raised or recessed circular leaf scar, and minority has petiole residual Base and fibrous root residual.Body is light, and matter is crisp, frangibility, section rufous, and vascular bundle is in yellow point-like, arranges cyclization.Odorless, lightly seasoned, Micro-puckery.The strong bone of kidney tonifying, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisiies, falling winks frustrates, injured bone；External treatment Alopecia areata, vitiligo.Pharmacological action：1st, according to the researchs such as China Medicine University's week copper water, Rhizoma Drynariae extract (suitable active compound 20g/kg ) gavage to experimental rat bone injury healing have facilitation.2. Rhizoma Drynariae water decoction 7.5-50g/kg gavage, to rat experiment Property arthritis have stimulation bone articular cartilage compensatory cellular proliferative effect, and can partly improve due to mechanical stress line change make Become the degeneration of articular cartilage, thus reducing osteoarthritis variability.3. to increase In vitro culture big for Rhizoma Drynariae flavanone glycoside The Beating Rate of white mouse neonatal rat myocardial cell, makes contraction strong, and myocardial cell is had pace-making act on, and its mechanism of action may It is similar to a kind of beta-receptor agonist.4. Rhizoma Drynariae decocting liquid (100%) 0.8ml/kg is administered orally, can be obvious to Experimental Hyperlipemia rabbit Prophylactic serum cholesterol, the rising of triglyceride, and the formation of aorta wall atherosclerotic plaque can be prevented.5. guinea-pig studies carry Show, Rhizoma Drynariae decoct and kanamycin share the toxic action that can mitigate kanamycin to cochlea, but in can not controlling after drug withdrawal The deaf development of toxicity.6. Rhizoma Drynariae decoct in vitro can suppress staphylococcic growth.Rhizoma Drynariae water decoction 7.5,10, 25th, 50g/kg is administered orally, and to chondrocytes of rat osteoarthritis mode, has the chondrocyte that has some improvement, postpones cell regeneration change, fall The function of low osteoarthritis variability, increases with dosage, and effect increases, and acts on preferably after being administered two months.Rhizoma Drynariae decocting Agent 100g (crude drug)/kg/ days is administered orally giving kanamycin for first 2 hours, continuous 8 days, can mitigate the poison to cochlea for the kanamycin Property, but the development of toxic deafness after drug withdrawal can not be controlled.

The Cortex Eucommiae is Eucommiaceae Cortex Eucommiae platymiscium, containing higher chlorogenic acid.Chlorogenic acid also known as caffeoyl guinic acid, are plants A kind of Phenylpropanoid Glycosides class material of the intermediate product synthesis through phosphopentose pathway (HMS) during aerobic respiration.In recent years Result of study shows, Chlorogenic Acid in Eucommia ulmoides Oliv. Leaves content is higher, up to 1 to 5.5.Chlorogenic acid has function of gallbladder promoting, antibacterial, antiviral, fall Pressure, the multiple pharmacological effect such as leukocyte increasing and stimulating central nervous system system, is the industry such as health product, food, medicine, cosmetics Important source material, hence with Folium Eucommiae produce chlorogenic acid there are huge social benefit and economic implications.Pharmacological action nature and flavor Return through：Temperature；Sweet；Return liver and kidney channel.Indication：Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is powerless, gestation leakage Blood, frequent fetal movement；Hypertension.Test proves, Folium Eucommiae extract has broad-spectrum antibacterial, antioxidation, removes free radical and raising Immunity etc. acts on, and has promotion poultry fast-growth；Prevent and cure diseases；The effectiveness such as substitute antibiotics.

Radix Astragali extract has enhancing immunity, strengthens energy, resisting fatigue, mutation, liver protection, the work of suppression osteoclast With.Astragalus polysaccharidess have blood fat reducing, that is, reduce the effect of cholesterol and triglyceride, high density lipoprotein increasing；Can prevent With treatment cardiovascular and cerebrovascular disease, such as atherosclerosiss, coronary artery pathological changes, peripheral angiopathy and hyperlipemia etc..Yellow Stilbene first glycosides has the effect significantly reducing blood glucose, glycolated hemoglobin and urine protein, it is possible to decrease the AGEs in renal cortex and serum, Display astragaloside has antioxidation, and has inhibitory action to aldose reductase, also suppression proliferation of mesangial cells, mitigation The effect of renal hypertrophy.Add suitable adjuvant in astragaloside, can be made into oral formulations, it is used for preventing and treating diabetes Nephropathy.This product has enhancing immunity, strengthens energy, resisting fatigue, mutation, liver protection, the effect of suppression osteoclast.In tradition Medical science thinks, the Radix Astragali has functions that tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, expelling pus and toxin by strengthening QI, inducing diuresis to remove edema, expelling pus and promoting granulation.Modern pharmacology Research shows, the Radix Astragali has an enhancing human body immunity function, heart tonifying blood pressure lowering, blood sugar lowering, diuresis, defying age, resisting fatigue, antitumor, Antiviral, calmness, analgesia etc. act on.Astragalus polysaccharidess 250mg/kg, 500mg/kg lumbar injection, to normal mouse and hydrogenation can " yang deficiency " mice caused by pine, room temperature swimming time all has notable prolongation effect, and increases mice adrenal gland weight under stress state. Radix Astragali extractive solution is to class in the rat plasma Determination of cortisol under Suppressor cells state, adrenal gland's weight and adrenal cortical cell Lipid void content is all significantly improved effect.Cerebral anoxia caused by the ligation of carotid of both sides, all has notable antagonism, can be bright The aobvious time-to-live extending mice.To prevention senile arteriosclerosis, improve old and feeble pulmonary function has certain meaning to the Radix Astragali.Body Outer culture human embryonic lung diploid fibroblast survived to 52 generations, and contained 0.2% Radix Astragali and produce the cultured cells of liquid and survive to 77 In generation, in medication group cellular senescence process, the change of organelle is essentially identical with the old and feeble no-load voltage ratio rule of cellular control unit, but it changes Become mild degree, rate of change is relatively slow, and the Golgi complex of particularly medication group cell is especially flourishing, although cell declines Their not very agings always.Research has shown that the Radix Astragali has the good effect lengthened the life, and using it as the anti-ageing medicine lengthening one's life, is worth height Degree is paid attention to and is developed.Astragalus polysaccharidess have obvious antagonism to tubercle bacillus affection;And have been found that other compositions such as aminoacid, biology Alkali, flavone etc. have the effect of the raw stomatitis virus of significantly anti-folliculus.Animal and development of evil in febrile disease cell experiment show, Radix Astragali injection pair In mice neonatal rat body, epidemic hemorrhagic fever, the course of infection of virus (EHFV) have certain blocking effect.The Radix Astragali is congratulated to external will Shigella flexneri, anthrax bacillus, a- promoting blood circulation streptococcus, Streptococcus sanguiss, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, golden yellow Color staphylococcuses, Staphylococcus citreus, Staphylococcus albus and bacillus subtilis etc. have antibacterial action.

Radix Puerariae extract derives from the dry root of legume pueraria lobata.Perennial fallen leaves liana, up to 10m, Herb is yellow Brown coarse wool.Tuber is cylindric, plump, crust lark, internal silty, and fibroids are very strong.It is born in hillside thick grass roadside and dredge More dark and damp place in woods.Energy expansion of blood vessels, improves blood circulation；Reduce myocardial oxygen consumption, anticancer；Increase arteria coronaria stream Amount, adjusts blood microcirculation；Treat the sudden deafness of each age level；Reduce cardiovascular and cerebrovascular disease dangerous.Have blood sugar lowering, Blood fat, antiinflammatory etc. act on.

Concha Ostreae extract, another name oyster clam, left Gu Concha Ostreae, are a kind of brownish-yellow powder.Purposes：Medicines and Health Product, beverage and Food additive etc..Meridian distribution of property and flavor：It is slightly cold；Salty；Return liver, gallbladder, kidney channel.Indication：Suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, convergence is solid Puckery.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula subcutaneous nodule, abdominal mass mass in the abdomen.

Magnesium stearate is the fine powder of the light no grittiness of white；Micro- have special smell；Contact soapy feeling with skin.This product water, Insoluble in ethanol or ether, it is mainly used as lubricant, antiplastering aid, fluidizer.Particularly suitable oils, the granulation of extract medicament, The granule made has good mobility and compressibility.It is used as fluidizer in direct compression.It is alternatively arranged as filter aid, clarification Agent and drip infusion, and the suspending agent of liquid preparation, thickening agent.Purposes is stabilizer；Lubricant；Pharmaceutic adjuvant.

Specific embodiment

Increase the capsule of bone density, implant is prepared from by the raw material of following weight：25 grams of Rhizoma Drynariae extract, Du 25 grams of secondary extract, 80 grams of Radix Astragali extract, 70 grams of Radix Puerariae extract, 180 grams of Concha Ostreae extract, 18 grams of starch, magnesium stearate 2 Gram.Above-mentioned raw materials make 1000 capsules, 0.4 gram every.Starch and magnesium stearate meet Pharmacopoeia of People's Republic of China 2005 The relevant regulations of year version two, major ingredient meets the requirement of company standard Appendix B, and described capsule body is No. 0 Capsuleses, symbol Close the regulation of Pharmacopoeia of People's Republic of China version Capsuleses in 2000.

A kind of preparation method of the capsule increasing bone density as above, its preparation method is as follows：

1）The raw material of above-mentioned weight is crossed respectively standby after 60 mesh sieves；

2）The raw material of the above-mentioned weight after sieving is placed in mixer and mixes 30 minutes, is allowed to uniform color unanimously, obtains mixing Powder；

3）Using capsule filling machine, above-mentioned mixed powder is filled in capsule body, 0.4 gram every, the capsule body filled is placed in Polish in capsule polisher, make capsule surface bright and clean, screened after polishing, choose flat capsule, broken capsule, empty pocket and leakage powder capsule；

4）Pass through Aluminium-coating Packer with the PVC board meeting YBB00212005 standard and the aluminium foil meeting YBB00152002 standard To step 3）Capsule after middle screening is wrapped inside dress, the every plate of packing specification 12；

5）Outer package operation mounted box, every box 2 plate will be proceeded to through the packaged capsule of Aluminium-coating Packer, obtain finished product, packing instructions： After receiving etui, by printed for box lot number, print procedure requires the name of an article, specification, and lot number printing is clear, correct, and finished product is used Co⁶⁰Sterilizing, dosage is 6KGy, extracts inspection, put in storage after the assay was approved after sterilizing.

Claims (3)

1. a kind of capsule increasing bone density, makes including capsule body and the implant being filled in capsule body, its feature exists In described implant is to be prepared from by the raw material of following parts by weight：25 parts of Rhizoma Drynariae extract, Cortex Eucommiae extract 25 Part, 80 parts of Radix Astragali extract, 70 parts of Radix Puerariae extract, 180 parts of Concha Ostreae extract, 18 parts of starch, 2 parts of magnesium stearate.

2. according to claim 1 increase bone density capsule it is characterised in that：Described capsule body is No. 0 hollow glue Capsule.

3. a kind of as claimed in claim 1 increase bone density capsule preparation method it is characterised in that its preparation method such as Under：

1）The raw material of above-mentioned parts by weight is crossed respectively standby after 60 mesh sieves；

2）The raw material of the above-mentioned parts by weight after sieving is placed in mixer and mixes 30 minutes, obtains mixed powder；

3）Using capsule filling machine, above-mentioned mixed powder is filled in capsule body, the capsule body filled is placed in capsule polisher Middle polishing, is screened after polishing, chooses flat capsule, broken capsule, empty pocket and leakage powder capsule；

4）Pass through Aluminium-coating Packer with the PVC board meeting YBB00212005 standard and the aluminium foil meeting YBB00152002 standard To step 3）Capsule after middle screening is wrapped inside dress, the every plate of packing specification 12；

5）Outer package operation mounted box, every box 2 plate will be proceeded to through the packaged capsule of Aluminium-coating Packer, obtain finished product, finished product Co⁶⁰ Sterilizing, dosage is 6KGy, extracts inspection, put in storage after the assay was approved after sterilizing.