CN105012746A - Pain-relieving capsule for treating migraine and preparation method of pain-relieving capsule - Google Patents
Pain-relieving capsule for treating migraine and preparation method of pain-relieving capsule Download PDFInfo
- Publication number
- CN105012746A CN105012746A CN201510475235.0A CN201510475235A CN105012746A CN 105012746 A CN105012746 A CN 105012746A CN 201510475235 A CN201510475235 A CN 201510475235A CN 105012746 A CN105012746 A CN 105012746A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- minute
- semen maydis
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pain-relieving capsule for treating migraine. The pain-relieving capsule for treating the migraine is prepared from, by weight, 3-9 parts of olibanum, 5-9 parts of myrrh, 1-5 parts of angelica roots, 2-6 parts of motherwort fruit, 1-3 parts of cassia seeds, 3-7 parts of panax notoginseng, 4-6 parts of Chinese parsnip roots, 2-4 parts of gastrodia elata, 5-15 parts of chastetree fruit, 5-9 parts of cinnamon, 3-6 parts of all-grass of drooping carpesium, 1-3 parts of earthworms, 6-10 parts of costustoot, 10-50 parts of corns and 10-15 parts of white fungus. The pain-relieving capsule has the remarkable effect on migraine and the good relaxation effect on symptoms such as dizziness and nausea caused by the migraine, the local common medicinal materials selected and used by the pain-relieving capsule for treating the migraine are low in price, and the economical burden on patients is relieved.
Description
Technical field
The invention discloses one and treat migraine acesodyne capsule, especially relate to one and treat migrainous acesodyne capsule and preparation method thereof, the invention belongs to traditional Chinese medicine field.
Background technology
Migraine (migraine) is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.
The migrainous cause of disease is still not clear, may with following factors about inherited genetic factors: the migraine patient of about 60% has family history, its relatives occur that migrainous risk is 3 ~ 6 times of population, familial migraineur not yet finds consistent mendelian inheritance, reflects the interaction of different penetrance and polygenic inheritance feature and environmental factors.Familial hemiplegia type migraine is the clear and definite autosomal dominant inheritance, AD having Height Anomalies penetrance, has been positioned at 19p13(and has suddenlyd change relevant with the voltage door P/Q calcium channel gene mistranslation that brain is expressed), three disease gene sites such as 1q21 and 1q31.E&M factor: primary disease women is more than male, and how in adolescence morbidity, menstrual phase is easily shown effect, and trimester of pregnancy or post menopausal outbreak reduce or stop.This prompting E&M factor participates in migrainous morbidity.In addition, the Developmental and Metabolic Disorder such as 5-hydroxy tryptamine (5-HT), norepinephrine, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and arachidonic acid also can affect migraine and occurs.Diet and Nervous and Mental Factors: migraine can by some food and drug-induced, food comprises the cheese containing tyramine, the meat containing nitrite antiseptic and cure foods, containing the chocolate of phenethylamine, food additive as sodium glutamate (monosodium glutamate), red wine and wine etc.Medicine comprises oral contraceptive and vasodilation as nitroglycerin etc.Other environment and Nervous and Mental Factors such as nervous, overwork, excited, hypersomnia or very few, menstruation, high light also can bring out.
Migraine complication: (1) chronic migraine: migraine monthly Headache attacks, more than 15 days, continuous 3 months or more than 3 months, and the headache getting rid of that overdose causes, can be thought of as chronic migraine.(2) statural hemicranicus: migraine persistent period >=72 hours, and pain degree is comparatively serious, but can have the of short duration catabasis because sleep or medicinal application obtain therebetween.(3) without the lasting tendency of infarction: refer to that migraine without aura patient occurs that in once showing effect a kind of tendency or multiple premonitory symptom continue more than 1 week, mostly be bilateral; This show effect other symptoms with to show effect in the past similar; Cerebral infarction focus must be got rid of by neuroimaging.(4) migraine infarction: the ischemic infarct occurring the corresponding blood supply region of intracranial under rare occasion after migraine aura symptom, this premonitory symptom often continues more than 60 minutes, and ischemic infarct focus is confirmed by neuroimaging, be called migraine infarction.(5) the epilepsy sample that migraine is brought out shows effect: under rare occasion, migraine aura symptom can trigger epilepsy outbreak, and epilepsy outbreak occurs in premonitory symptom or within latter 1 hour.
In the migrainous patent of existing treatment, Authorization Notice No. CN 102302751 B(application number 201110238307.1) Chinese patent literature disclose one and treat migrainous Chinese medicine, it is characterized in that: be made up of the raw material of following parts by weight: Rhizoma Panacis Japonici 5-10 part, Fructus Mangifera Indicae root 3-5 part, Herba Artemisiae Anomalae 10-12 part, Herba Salomoniae Cantoniensis 4-6 part, Folium Baeckeae 4-6 part, Rhizoma Cyperi 15-20 part, Radix Saposhnikoviae 3-5 part, Radix Angelicae Sinensis 3-5 part, Herba Asari 1-3 part, Radix Angelicae Dahuricae 3-5 part, Rhizoma Et Radix Notopterygii 3-5 part, Radix Angelicae Pubescentis 3-5 part, Radix Glycyrrhizae 1-3 part, Rhizoma Atractylodis 3-5 part, Radix Ophiopogonis 3-5 part, Radix Scutellariae 4-6 part, Fructus Viticis 2-4 part, Flos Chrysanthemi 2-4 part, Rhizoma Zingiberis Recens fresh goods 6-8 part, preparation method: all raw materials are mixed, and with Burdick lamp, sterilization processing is carried out to it, then, put people's baking box to pharmaceutical drying, with pulverizer, medicine is pulverized, be then ground into powder face, then stir in loading hard capsule.Authorization Notice No. CN 103285262 B(application number 201310240998.8) Chinese patent literature disclose one and treat migrainous Chinese medicine, it is characterized in that, it is prepared from by the medical material of following weight portion: Semen Cassiae 6 parts, Fructus trachycarpi 12 parts, Herba Astragali Melilotoidis 5 parts, Vicia unijuga 10 parts, Fructus Aurantii Immaturus 15 parts, Folium Acanthopanacis Radicis 9 parts, Wood-scoop dish 12 parts, the Radix Aucklandiae 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 8 parts.
In a word, Chinese medicine achieves good curative effect in treatment primary disease, but also there are some problems: clinical also not for the medicine of spleen invigorating warming middle-JIAO, activating qi for lowering adverse qi, consumer product dredge stasis, purging heat to relax the bowels, has much room for improvement to improving the misery that migraine brings.
Summary of the invention
Along with the development of Chinese Chinese medicine, in prevention and controlling migraine, people gradually appreciate Chinese medicine and have no side effect in the migraine process of preventing and treating, patient bears painful little, and the advantage that cost is saved relatively, for the migrainous present situation of existing western medical treatment, an object of the present invention is to provide one to treat migrainous acesodyne capsule, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
One treats migrainous acesodyne capsule, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 3-9 part, Myrrha 5-9 part, Radix Angelicae Dahuricae 1-5 part, Fructus Leonuri 2-6 part, Semen Cassiae 1-3 part, Radix Notoginseng 3-7 part, Radix Saposhnikoviae 4-6 part, Rhizoma Gastrodiae 2-4 part, Fructus Viticis 5-15 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 5-9 part, Wood-scoop dish 3-6 part, Pheretima 1-3 part, Radix Aucklandiae 6-10 part, Semen Maydis 10-50 part, Tremella 10-15 part.
One treats migrainous acesodyne capsule, preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 5-7 part, Myrrha 6-8 part, Radix Angelicae Dahuricae 2-4 part, Fructus Leonuri 3-5 part, Semen Cassiae 1.5-2.5 part, Radix Notoginseng 4-6 part, Radix Saposhnikoviae 4.5-5.5 part, Rhizoma Gastrodiae 2.5-3.5 part, Fructus Viticis 8-13 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 6-8 part, Wood-scoop dish 4-5 part, Pheretima 1.5-2.5 part, Radix Aucklandiae 7-9 part, Semen Maydis 20-40 part, Tremella 11-14 part.
One treats migrainous acesodyne capsule, better preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: Olibanum 6 parts, Myrrha 7 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Leonuri 4 parts, Semen Cassiae 2 parts, Radix Notoginseng 5 parts, Radix Saposhnikoviae 5 parts, 3 parts, Rhizoma Gastrodiae, Fructus Viticis 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 7 parts, Wood-scoop dish 4.5 parts, Pheretima 2 parts, the Radix Aucklandiae 8 parts, Semen Maydis 30 parts, 12.5 parts, Tremella.
Another object of the present invention is just to provide the migrainous preparation method of above-mentioned treatment.
Treat a preparation method for migrainous acesodyne capsule, step is as follows:
1. by the warm water soaking 10-15 minute of dry tremella with 30-40 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in the interior immersion of the container filling white sugar water 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, crosses 60-100 mesh sieve, the Semen Maydis quarrel clear water after sieving is eluriated 1-5 time, is placed in marmite, add Semen Maydis quarrel weight 1-3 clear water doubly, soak 20-40 minute stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 1-3 hour stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 80-100 DEG C, soak 10-20 minute, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with crude drug weight 1-3 yellow wine spray doubly, steaming and decocting 10-20 minute after water boils, take out fried dry, grind to form fine powder, cross 80-120 mesh sieve stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, after boiling, change little fire simmer slowly 50-70 minute (preferably 60 minutes), put into step 1. gained Tremella, stir into thick paste, thick paste is dried 10-30 minute, dry at 50-60 DEG C, be prepared into capsule according to the processing technique of capsule.
The preparation method of above-mentioned acesodyne capsule, step 1. by dry tremella with 33-38 DEG C warm water soaking 11-14 minute (preferred, by the warm water soaking 12 minute of dry tremella with 35 DEG C).
The preparation method of above-mentioned acesodyne capsule, 2. step crosses 70-90 mesh sieve, and the Semen Maydis quarrel clear water after sieving is eluriated 2-4 all over (preferred, to cross 80 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 3 times).
The preparation method of above-mentioned acesodyne capsule, 2. step adds Semen Maydis quarrel weight 1.5-2.5 clear water doubly, soaks 25-35 minute (preferred, to add the clear water of Semen Maydis quarrel weight 2 times, soak 30 minutes).
The preparation method of above-mentioned acesodyne capsule, step be 3. placed in medicated wine soak 1.5-2.5 hour stand-by (preferred, be placed in medicated wine soak 2 hours stand-by).
The preparation method of above-mentioned acesodyne capsule, 4. step uses the hot water of 85-95 DEG C, soaks 13-18 minute (preferred, with the hot water of 90 DEG C, to soak 15 minutes).
The preparation method of above-mentioned acesodyne capsule, step is 4. even with crude drug weight 1.5-2.5 yellow wine spray doubly, after water boils steaming and decocting 13-18 minute (preferred, to spray even, steaming and decocting 15 minutes after water boils with the yellow wine of crude drug weight 2 times).
This acesodyne capsule, to migraine Be very effective, has good mitigation, the local common medical material of multiselect of the present invention to the symptom such as dizzy, nauseating caused by migraine, cheap, alleviates the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Olibanum: pungent, bitter, temperature.Return through GUIXIN, liver, spleen channel.The pain relieving of effect blood-activating and qi-promoting, detumescence and promoting granulation.Cure mainly for obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.
Myrrha: acrid in the mouth, hardship, property is put down.Return through GUIXIN, liver, spleen channel.The analgesic therapy of effect dissipating blood stasis, detumescence and promoting granulation.Cure mainly for obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea. postpartum stagnation, mass in the abdomen is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the diseases such as carbuncle skin infection.
The Radix Angelicae Dahuricae: be used as medicine with root, the functions such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, rhinitis, toothache.The diseases such as leucorrhea with red and white discharge, pain furuncle and phyma poison, also can make spice.
Fructus Leonuri: pungent, bitter, is slightly cold.Return through GUIXIN bag, Liver Channel.Effect promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.Cure mainly for menoxenia, amenorrhea dysmenorrhea, cataract, dizzy distending pain.
Semen Cassiae: Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, reducing blood pressure and blood fat.
Radix Notoginseng: sweet, micro-hardship, temperature.Gui Jing returns liver, stomach warp.Effect dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly for spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Gui Jing returns bladder, lung, spleen, Liver Channel.Effect expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus just, insufficiency of the spleen leading to overabundance of dampness.
Rhizoma Gastrodiae: sweet, flat, enter spleen, kidney, liver, gallbladder, heart channel, endogenous wind stopping, arresting convulsion.Control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom.
Fructus Viticis: for anemopyretic cold, headache wind syndrome of head.The pungent wind that can fall apart of this product, be slightly cold heat clearing away, frivolous up, and the heresy of main loose women's head-ornaments, has the effect of wind-expelling pain-stopping, with controlling affection due to external wind and heat, headache and dizzy.
Cortex cinnamomi japonici (Ramulus Cinnamomi) skin: effect: warming middle-JIAO is regulated the flow of vital energy; Diaphoresis expelling pathogenic factors from muscles, cures mainly: cold of insufficiency type and stomachache; Have loose bowels; Chills and pain of the waist and kness; Anemofrigid cold; Menoxenia, effect is classified: warming middle-JIAO QI regulating medicine; Diaphoresis expelling pathogenic factors from muscles medicine
Wood-scoop dish: nature and flavor: bitter in the mouth; Pungent; Cold in nature, function cures mainly: heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main cold, fever; Hyperpyrexia and infantile convulsion; Laryngopharynx swelling and pain; Zha rib; Toothache; Urinary tract infection; Tuberculous lymphadenitis; Skin infection furuncle and phyma; Milk cattle adenitis.
Pheretima: calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, hemiplegia LUMBRICUS is dry waits disease.External is coated with the disease such as erysipelas, dermatitis rhus.1, clearing heat for calming endogenous wind: cure mainly high fever infantile convulsion, wind symptom is twitched.2, lung-clearing asthma-relieving: the asthma of lung-heat productive cough can be controlled, better to lung heat type bronchial asthma curative effect.3, inducing diuresis for treating stranguria syndrome: be applicable to damp invasion of lower energizer, the puckery pain of pyretic stranguria.4, current meridians: available pyretic arthralgia of controlling saves swollen swelling pain; Suitable compatibility also can control arthralgia due to cold; Compatibility replenishing qi and promoting blood flow medicine is usually used in blood stasis due to qi deficiency, and meridians are unfavorable, aphasia hemiplegia person.
The Radix Aucklandiae: effect: circulation of qi promoting, pain relieving, spleen invigorating, helps digestion, and cures mainly: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia; Middle gas is not economized; Sudden deafness; Snake bite and insect sting; Toothache.
Semen Maydis: modern study confirms, containing abundant unsaturated fatty acid in Semen Maydis, especially linoleic content is up to more than 60%, and the vitamin E synergism in it and Fructus Maydis, can reduce serum cholesterol concentration and prevent it to be deposited on blood vessel wall.Therefore, Semen Maydis has certain preventive and therapeutic action to coronary heart disease, atherosclerosis, hyperlipemia and hypertension etc.Vitamin E also can promote that human body cell divides, slow down aging.Also containing a kind of longevity factor----glutathion in Semen Maydis, it is in the presence of selenium, generates GSH-POX, has and renew one's youth, the function of slow down aging.The selenium contained in Semen Maydis and magnesium have anti-cancer and kill cancer action, and the decomposition of selenium energy acceleration bodies endoperoxide, makes malignant tumor can not get the supply of oxygen molecule and be suppressed.Magnesium on the one hand also can the development of anticancer, and refuse in body can be impelled to excrete on the other hand, this is also significant to anti-cancer.Its glutamic acid contained has certain brain-invigorating.Except containing except carbohydrate, protein, fat, carotene, also containing nutrient substance such as dextrinosan, riboflavin, vitamin in Semen Maydis.These materials have very large benefit to the disease such as prevention of cardiac, cancer.
Tremella: Tremella sweet in the mouth, light, property are flat, nontoxic, effect of existing spleen reinforcing appetizing, has again the effect of QI invigorating bowel relieving, nourishing YIN and moistening the lung.Can body immunity be strengthened, the tolerance of tumor patient to Radiotherapy chemotherapy can be strengthened again.Tremella is rich in natural plant colloid, and additional its has the effect of YIN nourishing, is can the good skin moistening food of long-term taking.
Acesodyne capsule of the present invention debates the principle of disease control based on Chinese medicine, and treatment is more comprehensive, lasting medicine, take into account inside and outside belonging to, the migraine prescription for the treatment of both the principal and secondary aspects of a disease, has fabulous preventive and therapeutic effect to migraine, has fabulous opsonic action for the health thin and weak because of chronic pain.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1one treats migrainous acesodyne capsule, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Olibanum 3 parts, Myrrha 5 parts, the Radix Angelicae Dahuricae 1 part, Fructus Leonuri 2 parts, Semen Cassiae 1 part, Radix Notoginseng 3 parts, Radix Saposhnikoviae 4 parts, 2 parts, Rhizoma Gastrodiae, Fructus Viticis 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 5 parts, Wood-scoop dish 3 parts, Pheretima 1 part, the Radix Aucklandiae 6 parts, Semen Maydis 10 parts, 10 parts, Tremella.
One treats migrainous acesodyne capsule, and preparation process is as follows:
1. by the warm water soaking 10 minute of dry tremella with 30 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill white sugar water container in soak 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, cross 60 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 1 time, is placed in marmite, add Semen Maydis quarrel weight 1 times clear water, soak 20 minutes stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 1 hour stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 80 DEG C, soak 10 minutes, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with the yellow wine spray of crude drug weight 1 times, steaming and decocting 10 minutes after water boils, take out fried dry, grind to form fine powder, cross 80 mesh sieves stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, and changes little fire and simmer 50 minutes slowly after boiling, put into step 1. gained Tremella, stir into thick paste, thick paste is dried 10 minutes, dry at 50 DEG C, be prepared into capsule according to the processing technique of capsule.
model case one:king XX, man, 48 years old, Jinan City, Shandong Province personage, the employee of certain company, long-term work is tired, have a rest bad, before 1 year, occurred left side of head pain without obvious inducement, every day substantially can timing pain, the time of general pain can not be oversize, and pain is got up just as pinprick, and people is on tenterhooks, can not work, sometimes can not taking food of pain, removes examination in hospital: doctor is according to basic situation, be diagnosed as: migraine, doctor advised patient takes acesodyne capsule of the present invention.
Take the embodiment of the present invention 1 gained acesodyne capsule, each 2, every day takes 2 times sooner or later, within 5 days, is a course for the treatment of, take a course for the treatment of, patient's readme, the pain that former every day all regularly shows effect, within 3 days, remained dormant, after continuing again to take 1 course for the treatment of, malaise symptoms disappears substantially.
embodiment 2one treats migrainous acesodyne capsule, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Olibanum 9 parts, Myrrha 9 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Leonuri 6 parts, Semen Cassiae 3 parts, Radix Notoginseng 7 parts, Radix Saposhnikoviae 6 parts, 4 parts, Rhizoma Gastrodiae, Fructus Viticis 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 9 parts, Wood-scoop dish 6 parts, Pheretima 3 parts, the Radix Aucklandiae 10 parts, Semen Maydis 50 parts, 15 parts, Tremella.
One treats migrainous acesodyne capsule, and preparation process is as follows:
1. by the warm water soaking 15 minute of dry tremella with 40 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill white sugar water container in soak 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, cross 100 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 5 times, is placed in marmite, add Semen Maydis quarrel weight 3 times clear water, soak 40 minutes stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 3 hours stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 100 DEG C, soak 20 minutes, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with the yellow wine spray of crude drug weight 3 times, steaming and decocting 20 minutes after water boils, take out fried dry, grind to form fine powder, cross 120 mesh sieves stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, and changes little fire and simmer 70 minutes slowly after boiling, put into step 1. gained Tremella, stir into thick paste, thick paste is dried 30 minutes, dry at 60 DEG C, be prepared into capsule according to the processing technique of capsule.
embodiment 3one treats migrainous acesodyne capsule, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Olibanum 5 parts, Myrrha 6 parts, the Radix Angelicae Dahuricae 2 parts, Fructus Leonuri 3 parts, Semen Cassiae 1.5 parts, Radix Notoginseng 4 parts, Radix Saposhnikoviae 4.5 parts, 2.5 parts, Rhizoma Gastrodiae, Fructus Viticis 8 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 6 parts, Wood-scoop dish 4 parts, Pheretima 1.5 parts, the Radix Aucklandiae 7 parts, Semen Maydis 20 parts, 11 parts, Tremella.
One treats migrainous acesodyne capsule, and preparation process is as follows:
1. by the warm water soaking 11 minute of dry tremella with 33 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill white sugar water container in soak 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, crosses 70 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 1-5 time, is placed in marmite, add the clear water of Semen Maydis quarrel weight 1.5 times, soak 25 minutes stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 1.5 hours stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 85 DEG C, soak 13 minutes, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with crude drug weight 1-3 yellow wine spray doubly, steaming and decocting 13 minutes after water boils, take out fried dry, grind to form fine powder, cross 90 mesh sieves stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, and changes little fire and simmer 55 minutes slowly after boiling, put into step 1. gained Tremella, stir into thick paste, thick paste is dried 15 minutes, dry at 53 DEG C, be prepared into capsule according to the processing technique of capsule.
embodiment 4one treats migrainous acesodyne capsule, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Olibanum 7 parts, Myrrha 8 parts, the Radix Angelicae Dahuricae 4 parts, Fructus Leonuri 5 parts, Semen Cassiae 2.5 parts, Radix Notoginseng 6 parts, Radix Saposhnikoviae 5.5 parts, 3.5 parts, Rhizoma Gastrodiae, Fructus Viticis 13 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 8 parts, Wood-scoop dish 5 parts, Pheretima 2.5 parts, the Radix Aucklandiae 9 parts, Semen Maydis 40 parts, 14 parts, Tremella.
One treats migrainous acesodyne capsule, and preparation process is as follows:
1. by the warm water soaking 14 minute of dry tremella with 38 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill white sugar water container in soak 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, crosses 90 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 1-5 time, is placed in marmite, add the clear water of Semen Maydis quarrel weight 2.5 times, soak 35 minutes stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 2.5 hours stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 95 DEG C, soak 18 minutes, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with the yellow wine spray of crude drug weight 2.5 times, steaming and decocting 18 minutes after water boils, take out fried dry, grind to form fine powder, cross 110 mesh sieves stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, and changes little fire and simmer 65 minutes slowly after boiling, put into step 1. gained Tremella, stir into thick paste, thick paste is dried 25 minutes, dry at 58 DEG C, be prepared into capsule according to the processing technique of capsule.
model case two:soviet Union xx, man, 49 years old, people from Jiyang County, Jinan City, Shandong Province.Symptom: 1 year cause be duration headache unbearably, patient's readme was begun before 1 year to occur having a headache in Zuo Temporal side, from the beginning of slightly, bitterly do in paroxysm, spring, outbreak was more acute, oral indometacin sheet can be alleviated, show effect over 1 year frequent, monthly show effect 4-5 time, each lasting 1-2 days, to make front aethomma dim spot, fuzzy depending on spy; During outbreak, twinge is fought sense, companion's Nausea and vomiting time heavy, and be on tenterhooks, local hospital is examined as angioneurotic headache, to wheat clothes peace preparation, first can alleviate, then gradually lose efficacy.Nearly March has a headache on the left of paroxysmal, and head sinks swollen, pain as being stabbed time heavy, and sore spot is fixing not to be moved, and still has sense of fighting during outbreak, companion's Nausea and vomiting.Clothes medicine-feeding is invalid.Have a medical check-up: sanity, spirit is poor, and cranial nerve is normal, and neck is soft, and myasthenia of limbs, muscular tension are normal, and bilateral pathology levies feminine gender.Thin white fur of tongue, deep-thready pulse string.Head CT and magnetic resonance examination normally, are diagnosed as: migraine.
Take the embodiment of the present invention 4 gained acesodyne capsule, each 2, every day takes 2 times sooner or later, it within 5 days, is a course for the treatment of, take a course for the treatment of, patient's self-induction attack times obviously reduces, after continuing to have taken 2 courses for the treatment of, substantially do not recur, during recurrence, pain degree alleviates, decreased duration, continues again to take 1 course for the treatment of, cure completely, not having Headache attacks 1 year more so far.
embodiment 5one treats migrainous acesodyne capsule, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Olibanum 6 parts, Myrrha 7 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Leonuri 4 parts, Semen Cassiae 2 parts, Radix Notoginseng 5 parts, Radix Saposhnikoviae 5 parts, 3 parts, Rhizoma Gastrodiae, Fructus Viticis 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 7 parts, Wood-scoop dish 4.5 parts, Pheretima 2 parts, the Radix Aucklandiae 8 parts, Semen Maydis 30 parts, 12.5 parts, Tremella.
One treats migrainous acesodyne capsule, and preparation process is as follows:
1. by the warm water soaking 12 minute of dry tremella with 35 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill white sugar water container in soak 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, crosses 80 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 1-5 time, is placed in marmite, add the clear water of Semen Maydis quarrel weight 2 times, soak 30 minutes stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 2 hours stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 90 DEG C, soak 15 minutes, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with the yellow wine spray of crude drug weight 2 times, steaming and decocting 15 minutes after water boils, take out fried dry, grind to form fine powder, cross 100 mesh sieves stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, and changes little fire and simmer 60 minutes slowly after boiling, put into step 1. gained Tremella, stir into thick paste, thick paste is dried 20 minutes, dry at 55 DEG C, be prepared into capsule according to the processing technique of capsule.
experimental example:1, selection of clinical: in order to verify the effect of Chinese medicine composition of the present invention, we have extracted 400 patients and have carried out the experiment of medicine, are equally divided into two groups, experimental group and matched group.
2, inclusion criteria: through being diagnosed as migrainous patient, in sick 10 days-5 years age, has cephalagra one or more.
3, prevention and controls: adopt acesodyne capsule of the present invention, each 2, every day takes 2 times sooner or later, within 5 days, is a course for the treatment of.
4, curative effect situation criterion: 1, effective: after drug administration, malaise symptoms alleviates or partial disappearance; 2, invalid: after drug administration, malaise symptoms is unchanged.We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis have been carried out to data.
Specific experiment result is as following table:
Table 1:
Table 2:
| group | drug categories | case load | migraineur oneself status evaluation |
| matched group | western medical treatment migraine method | 200 people | the people of 50% thinks that employing western medical treatment, health are subject to burden large, and spirit is all very painful with health. |
| acesodyne capsule of the present invention | acesodyne capsule of the present invention | 200 people | the people of 98% thinks with the present invention's treatment, effectively can alleviate every misery that migraine is brought. |
Prove through clinical trial, take acesodyne capsule of the present invention compared with the migrainous means of western medical treatment, control recurrence rate after healing low, means of prevention is more comprehensive thoroughly, have no side effect during taking, prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 100%, has good preventive and therapeutic effect to migraine.
Claims (10)
1. treat a migrainous acesodyne capsule, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Olibanum 3-9 part, Myrrha 5-9 part, Radix Angelicae Dahuricae 1-5 part, Fructus Leonuri 2-6 part, Semen Cassiae 1-3 part, Radix Notoginseng 3-7 part, Radix Saposhnikoviae 4-6 part, Rhizoma Gastrodiae 2-4 part, Fructus Viticis 5-15 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 5-9 part, Wood-scoop dish 3-6 part, Pheretima 1-3 part, Radix Aucklandiae 6-10 part, Semen Maydis 10-50 part, Tremella 10-15 part.
2. the migrainous acesodyne capsule for the treatment of according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Olibanum 5-7 part, Myrrha 6-8 part, Radix Angelicae Dahuricae 2-4 part, Fructus Leonuri 3-5 part, Semen Cassiae 1.5-2.5 part, Radix Notoginseng 4-6 part, Radix Saposhnikoviae 4.5-5.5 part, Rhizoma Gastrodiae 2.5-3.5 part, Fructus Viticis 8-13 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 6-8 part, Wood-scoop dish 4-5 part, Pheretima 1.5-2.5 part, Radix Aucklandiae 7-9 part, Semen Maydis 20-40 part, Tremella 11-14 part.
3. the migrainous acesodyne capsule for the treatment of according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Olibanum 6 parts, Myrrha 7 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Leonuri 4 parts, Semen Cassiae 2 parts, Radix Notoginseng 5 parts, Radix Saposhnikoviae 5 parts, 3 parts, Rhizoma Gastrodiae, Fructus Viticis 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin 7 parts, Wood-scoop dish 4.5 parts, Pheretima 2 parts, the Radix Aucklandiae 8 parts, Semen Maydis 30 parts, 12.5 parts, Tremella.
4. the preparation method of the migrainous acesodyne capsule of the treatment according to any one of claim 1-3, is characterized in that: step is as follows:
1. by the warm water soaking 10-15 minute of dry tremella with 30-40 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in the interior immersion of the container filling white sugar water 10 minutes, drain away the water, keep humidity;
2. corn distiller's dried grain is ground into the block of small rice grain size, crosses 60-100 mesh sieve, the Semen Maydis quarrel clear water after sieving is eluriated 1-5 time, is placed in marmite, add Semen Maydis quarrel weight 1-3 clear water doubly, soak 20-40 minute stand-by;
3. Pheretima is cleaned, is cut into four sections, be placed in medicated wine soak 1-3 hour stand-by;
4. Olibanum, Myrrha, the Radix Angelicae Dahuricae, Fructus Leonuri, Semen Cassiae, Radix Notoginseng, Radix Saposhnikoviae, Rhizoma Gastrodiae, Fructus Viticis, Cortex cinnamomi japonici (Ramulus Cinnamomi) skin, Wood-scoop dish and the Radix Aucklandiae are cleaned, be cut into filament, with the hot water of 80-100 DEG C, soak 10-20 minute, filter, filtering residue taking-up and step 3. gained Pheretima mix, and are placed on food steamer, even with crude drug weight 1-3 yellow wine spray doubly, steaming and decocting 10-20 minute after water boils, take out fried dry, grind to form fine powder, cross 80-120 mesh sieve stand-by;
5. by step 4. gained fine powder and step 2. gained Semen Maydis be cut and mix, big fire is boiled, after boiling, change little fire simmer slowly 50-70 minute (preferably 60 minutes), put into step 1. gained Tremella, stir into thick paste, thick paste is dried 10-30 minute, dry at 50-60 DEG C, be prepared into capsule according to the processing technique of capsule.
5. the preparation method of acesodyne capsule according to claim 4, is characterized in that: step is 1. by the warm water soaking 11-14 of dry tremella 33-38 DEG C minute (preferred, by the warm water soaking 12 minute of dry tremella with 35 DEG C).
6. the preparation method of acesodyne capsule according to claim 4, is characterized in that: 2. step crosses 70-90 mesh sieve, and the Semen Maydis quarrel clear water after sieving is eluriated 2-4 all over (preferred, to cross 80 mesh sieves, the Semen Maydis quarrel clear water after sieving is eluriated 3 times).
7. the preparation method of acesodyne capsule according to claim 4, is characterized in that: 2. step adds Semen Maydis quarrel weight 1.5-2.5 clear water doubly, soaks 25-35 minute (preferred, to add the clear water of Semen Maydis quarrel weight 2 times, soak 30 minutes).
8. the preparation method of acesodyne capsule according to claim 4, is characterized in that: step be 3. placed in medicated wine soak 1.5-2.5 hour stand-by (preferred, be placed in medicated wine soak 2 hours stand-by).
9. the preparation method of acesodyne capsule according to claim 4, is characterized in that: 4. step uses the hot water of 85-95 DEG C, soaks 13-18 minute (preferred, with the hot water of 90 DEG C, to soak 15 minutes).
10. the preparation method of acesodyne capsule according to claim 4, it is characterized in that: step is 4. even with crude drug weight 1.5-2.5 yellow wine spray doubly, after water boils steaming and decocting 13-18 minute (preferred, to spray even with the yellow wine of crude drug weight 2 times, steaming and decocting 15 minutes after water boils).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510475235.0A CN105012746A (en) | 2015-08-06 | 2015-08-06 | Pain-relieving capsule for treating migraine and preparation method of pain-relieving capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510475235.0A CN105012746A (en) | 2015-08-06 | 2015-08-06 | Pain-relieving capsule for treating migraine and preparation method of pain-relieving capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105012746A true CN105012746A (en) | 2015-11-04 |
Family
ID=54403285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510475235.0A Pending CN105012746A (en) | 2015-08-06 | 2015-08-06 | Pain-relieving capsule for treating migraine and preparation method of pain-relieving capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105012746A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267760A (en) * | 2015-12-01 | 2016-01-27 | 王平平 | Medicine for treating migraine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120114800A (en) * | 2011-04-08 | 2012-10-17 | 징 펑 쉬 | Pharmaceutical composition of the treatment and prevention of cephalopathy or foot diseases and apparatus using the same |
| CN103751570A (en) * | 2014-02-13 | 2014-04-30 | 王怀方 | Orally taken traditional Chinese medicine for treating migraine |
-
2015
- 2015-08-06 CN CN201510475235.0A patent/CN105012746A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120114800A (en) * | 2011-04-08 | 2012-10-17 | 징 펑 쉬 | Pharmaceutical composition of the treatment and prevention of cephalopathy or foot diseases and apparatus using the same |
| CN103751570A (en) * | 2014-02-13 | 2014-04-30 | 王怀方 | Orally taken traditional Chinese medicine for treating migraine |
Non-Patent Citations (2)
| Title |
|---|
| 王显杰: "止痛方治疗头痛30例", 《陕西中医》 * |
| 王瑞海: "西比灵与中药结合治疗偏头痛48例的体会", 《深圳中西医结合杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267760A (en) * | 2015-12-01 | 2016-01-27 | 王平平 | Medicine for treating migraine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102205108B (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
| CN102579940B (en) | Chinese medicine composition for curing infantile diarrhea and applied on navel | |
| CN103830749B (en) | A kind of gastrointestinal contrast agent | |
| CN105232987A (en) | Traditional Chinese medicine promoting neurosurgery postoperative rehabilitation | |
| CN104605372A (en) | Nutritional herbal cuisine based on cancer radiotherapy patient and preparation method thereof | |
| CN104784245A (en) | Medicine for treating cervical cancer | |
| CN105012746A (en) | Pain-relieving capsule for treating migraine and preparation method of pain-relieving capsule | |
| CN102988747B (en) | Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof | |
| CN103610858B (en) | The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition | |
| CN103520652B (en) | Traditional Chinese medicine composition for treating liver cancer | |
| CN105213876A (en) | A kind of medicament for treating insomnia and preparation method thereof | |
| CN104524461A (en) | Medicine composition for treating myocarditis and application thereof | |
| CN104069305A (en) | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof | |
| CN104707035B (en) | A kind of Chinese medicine composition for the treatment of combined spinal-epidural anesthesia Headache | |
| CN103705639A (en) | Chinese medicinal preparation for treating hydrocephalus | |
| CN105055948A (en) | Health-preserving porridge for prevention of cerebral infarction and cerebral hemorrhage and preparation method thereof | |
| CN104547518A (en) | Traditional Chinese medicine spray for preventing and treating acute heart failure and preparation method thereof | |
| CN104784587A (en) | Traditional Chinese medicine composition for treating endocrine disorder type infertility and preparation method thereof | |
| CN105194577A (en) | Medicament for treating hyperplasia of mammary glands | |
| CN104784444A (en) | Traditional Chinese medicine composition for treating hypertensive heart diseases and preparation method thereof | |
| CN104435589A (en) | Traditional Chinese medicine preparation for treating migraine and preparation method thereof | |
| CN104162038A (en) | Traditional Chinese medicine composition for treating neonatal seizures and preparation method thereof | |
| CN104027789A (en) | Traditional Chinese medicine composition for treating cold retardation type jaundice of newborn babies and preparing method thereof | |
| CN103638188A (en) | Chinese medicine for preventing and treating chronic osteomyelitis and preparation method thereof | |
| CN110522881A (en) | A kind of prevention and treatment lipoma Chinese medicine composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151104 |
|
| RJ01 | Rejection of invention patent application after publication |