CN103610858B - The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition - Google Patents
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses one and treat migraine, prosopalgic Chinese medicine composition, be prepared from by the crude drug of following weight proportioning: Fructus Viticis 20-40 part, Cornu Saigae Tataricae 3-7 part, Folium Mori 50-150 part, Flos Chrysanthemi 50-150 part, Caulis Polygoni Multiflori 20-40 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Atriplicis Sibiricae 20-40 part, Ramulus Mori 20-40 part, Arisaema Cum Bile 20-40 part, Fructus Pruni persicae immaturus 20-40 part and rice wine 100-200 part.Chinese medicine composition of the present invention has that preparation method is simple, taking convenience, be easy to carry and the feature of easy clothes for a long time, and this Chinese medicine composition also has activating blood circulation to dissipate blood stasis and dredge the collateral, expelling wind and cold, effect of understand things pain-stopping.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat migraine, prosopalgic Chinese medicine composition and preparation method thereof.
Background technology
Migraine (migraine) is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.
Migrainous pathogenesis is still not fully aware of, mainly contains following theory at present:
Blood vessel theory: traditional blood vessel theory thinks that migraine is constitutional angiopathy.Intracranial vessel shrinks and causes migraine aura symptom, and outer, the intracranial vessel expansion of cranium subsequently, tissues surrounding vascular produces vasoactive polypeptides and causes aseptic inflammation to cause the headache of pulsation.Carotid artery and superficial temporal artery local compression, vasoconstrictor peptide such as Ergotamine can alleviate this theory of stage of attack headache support.The clinical practices such as neuroimaging development TCD, PET, further developed blood vessel source theory, proposing tendency type is the same disease that vasospasm degree is different with Migraine without aura.Various neuron is different to the sensitivity of ischemia, the appearance of premonitory symptom is due to vasoconstriction, after blood flow reduces, the neuron of visual cortex is the most responsive to ischemia, therefore visual aura occurs at first, then increasing neuronal function is affected, then engenders other neurological symptoms such as finger is numb.
Neural theory: neural theory think migraine time function of nervous system change be primary, the change of blood flow is secondary.Migraine aura suppresses (corticalspreadingdepressing, CSD) to cause by autgmentability cortex.CSD refers to the neuroelectricity activity inhibition zone originating from brain rear portion cortex (occipital lobe) that various destructive stimulus causes, this inhibition zone is expanded to contiguous cortex with the speed of 2 ~ 5mm/min, and with occurring autgmentability oligemia (spreading0ligemia).Both are all not in accordance with cerebral arteries distributed expansion, but are undertaken by brain cortex cell architecture model, and expanded forward does not generally surmount Rolandic fissure.CSD can explain migraine aura symptom well.In addition, 5-hydroxy tryptamine (5-HT) participates in headache generation.When Headache attacks starts, 5-HT disengages from platelet, directly acts on intracranial thin vessels and makes it to shrink, and invest in blood vessel wall.When blood plasma 5-HT lowering of concentration, it acts on the tension contractility event resolves of large artery trunks, and headache appears in blood vessel wall expansion.5-HT is a kind of neurotransmitter, is again a kind of circulatory mediator, all has impact to neural and blood vessel.Treating migrainous triptan medicine is exactly central 5-HT receptor stimulating agent or partial agonist.This confirms that nervous dysfunction participates in migrainous episode process.
Trigemino-vascular theory: this theory anatomical physiology basis is trigemino-vascular complex (trigeminovascularcomplex).Intracranial Hyperalgesia tissue is as cerebrovascular, meningovascular, venous sinus, and its Perivascular nerve fiber fiber enters trigeminal ganglion with ophthalmic branch of trigeminal nerve, or enters 1,2 cervical nerves (C1, C2) roots afterwards from Posterior fossa; Both are after trigeminal ganglion and C1, C2 spinal ganglion change unit, and send nerve fiber to nervi trigeminus neck complex (trigeminocervicalcomplex), the latter is made up of spinal nucleus of trigeminal nerve tail end and C1, C2 relief angle; Nervi trigeminus neck complex sends nerve fiber, after brain stem intersects, be projected to thalamus.Surrounding's Theory of Pain Mechanism of this theory is thought, trigeminal ganglion infringement may be the neural basal that migraine produces.When after trigeminal ganglion and fiber irriate thereof, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), calcitonin-gene-related peptide (CGRP) and other neuropeptides can be caused to discharge to be increased.These active substances act on Neighbouring Brain blood vessel wall, can cause vasodilation and occur pulsatile headache, vascular permeability also can be made to increase, plasma protein extravasation, produce aseptic inflammation, and stimulate pain sensation fiber to import maincenter into, form vicious cycle.
Trigeminal neuralgia is modal cranial nerve diseases, and with the violent pain of the paroxysmal of recurrent exerbation in a side surface part nervi trigeminus areal area for main manifestations, the sickness rate 52.2/10 ten thousand of domestic statistics, female is slightly more than man, and sickness rate can increase with the age.Trigeminal neuralgia is multiple is born in middle-aged and elderly people, R)L.The feature of this disease is: in Head And Face nervi trigeminus distributed areas, and morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking.Pain lasts several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.
Trigeminal neuralgia can be divided into constitutional (symptomatic) trigeminal neuralgia and the large class of secondary trigeminal neuralgia two, and wherein primary trigeminal neuralgia is more common.Primary trigeminal neuralgia refers to have clinical symptoms, but applies various inspection and do not find and relevant organic disease of falling ill.Secondary trigeminal neuralgia is apart from clinical symptoms, and clinical and imaging examination can find that organic disease is as tumor, inflammation, vascular malformation etc. simultaneously.Secondary trigeminal neuralgia is more common in below 40 years old, adolescence, and usually do not have trigger point, risk factor is not obvious, and pain is often in persistence, and some patients can find to show with other of primary disease.Brain CT, MRI, nasopharynx part biopsy etc. help diagnosis.
The Chinese patent literature of application publication number CN103349692A (application number 201310192847.X) discloses a kind of Chinese medicine preparation for the treatment of migraine, Trigeminal Neuralgia, chooses Radix Ginseng 60-180g, Radix Angelicae Sinensis 60-180g, Flos Carthami 60-180g, Rhizoma Chuanxiong 80-240g, Radix Aconiti Preparata 80-240g, Radix Saposhnikoviae 80-240g, Radix Angelicae Pubescentis 80-240g, Caulis Sinomenii 90-270g, Fructus Chaenomelis 90-270g, Semen Ziziphi Spinosae 30-120g be prepared from.The Chinese patent literature of publication number CN102357238A (application number 201110328707.1) discloses one and treats prosopalgic Chinese medicine composition, is made up: Fructus Evodiae 8-10 gram, Radix Ginseng 9-15 gram of the raw material of following weight, Rhizoma Zingiberis Recens 9-15 gram, Fructus Jujubae 9-15 gram, Radix Asparagi 4-8 gram, Radix Ophiopogonis 4-8 gram, Rhizoma Cimicifugae 1-5 gram, Bidens paruiflora Willd. 4-8 gram, Pericarpium Papaveris 4-8 gram, Semen Persicae mud 1-3 gram, Flos Carthami 1-3 gram, Semen Pruni Salicinae 8-10 gram, Rhizoma Gastrodiae 4-6 gram.
In a word, Chinese medicine achieves good curative effect in treatment primary disease, but also there are some problems: clinically to activating blood circulation to dissipate blood stasis and dredge the collateral, expelling wind and cold, understand things pain-stopping is desirable not enough, has much room for improvement to the misery improving migraine, trigeminal neuralgia brings.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, the treatment migraine, prosopalgic Chinese medicine composition and preparation method thereof of easy clothes for a long time.This Chinese medicine composition has activating blood circulation to dissipate blood stasis and dredge the collateral, expelling wind and cold, effect of understand things pain-stopping.
Technical scheme of the present invention is:
One treats migraine, prosopalgic Chinese medicine composition, is prepared from by the crude drug of following weight proportioning: Fructus Viticis 20-40 part, Cornu Saigae Tataricae 3-7 part, Folium Mori 50-150 part, Flos Chrysanthemi 50-150 part, Caulis Polygoni Multiflori 20-40 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Atriplicis Sibiricae 20-40 part, Ramulus Mori 20-40 part, Arisaema Cum Bile 20-40 part, Fructus Pruni persicae immaturus 20-40 part and rice wine 100-200 part.
Foregoing Chinese medicine composition, preferred scheme is, is prepared from by the crude drug of following weight proportioning: Fructus Viticis 25-35 part, Cornu Saigae Tataricae 4-6 part, Folium Mori 80-120 part, Flos Chrysanthemi 80-120 part, Caulis Polygoni Multiflori 25-35 part, Pericarpium Citri Reticulatae 80-120 part, Fructus Atriplicis Sibiricae 25-35 part, Ramulus Mori 25-35 part, Arisaema Cum Bile 25-35 part, Fructus Pruni persicae immaturus 25-35 part and rice wine 130-180 part.
Foregoing Chinese medicine composition, better preferred scheme is prepared from by the crude drug of following weight proportioning: Fructus Viticis 30 parts, Cornu Saigae Tataricae 5 parts, 100 parts, Folium Mori, Flos Chrysanthemi 100 parts, Caulis Polygoni Multiflori 30 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Atriplicis Sibiricae 30 parts, Ramulus Mori 30 parts, Arisaema Cum Bile 30 parts, Fructus Pruni persicae immaturus 30 parts and 150 parts, rice wine.
According to the preparation method for the treatment of migraine noted earlier, prosopalgic Chinese medicine composition, step is as follows:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine soak 1-5 days, take out stand-by;
(2) step (1) gains are placed on tile dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 80-120 mesh sieve, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 60-100 mesh sieve;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite to be fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor is obtained concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1-2 hour, obtains drying object, dry at temperature is 70-90 DEG C;
(7) gained drying object is measured according to 0.3-0.7g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Foregoing preparation method, preferred scheme is: step (1) is soaked 2-4 days (preferably soaking 3 days) in rice wine.
Foregoing preparation method, preferred scheme is: step (2) crosses 90-110 mesh sieve (preferably 100 mesh sieves).
Foregoing preparation method, preferred scheme is: step (3) crosses 70-90 mesh sieve; (preferably 80 mesh sieves).
Foregoing preparation method, preferred scheme is: thick paste dries 1.3-1.7 hour (preferably 1.5 hours) by step (6).
Foregoing preparation method, preferred scheme is: step (6) dry at temperature is 75-85 DEG C (preferably 80 DEG C at dry).
Foregoing preparation method, preferred scheme is: the dosage form of step (7) gained tablet is 0.4-0.6g/ sheet (preferred 0.5g/ sheet).
Using method: for making the present invention reach optimum therapeuticing effect, half an hour takes after breakfast, lunch and dinner, each 3 grams 10 days is a course for the treatment of, rests the head on Chinese medicinal pillow of the present invention in bed.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Viticis: for anemopyretic cold, headache wind syndrome of head.The pungent wind that can fall apart of this product, be slightly cold heat clearing away, frivolous up, and the heresy of main loose women's head-ornaments, has the effect of wind-expelling pain-stopping.
Cornu Saigae Tataricae: salty in the mouth; Cold in nature.Suppressing the hyperactive liver to relieve the wind syndrome; Liver heat removing and eyesight improving; Removing pathogenic heat from blood and toxic substance from the body.Clearing away heat and relieving spasm, suppressing the hyperactive liver to relieve the wind syndrome, removing toxic substances and promoting subsidence of swelling.(relieving spasm by subduing liver-wind liver heat removing and eyesight improving heat-clearing and toxic substances removing) cures mainly: for the hot infantile convulsion of height, coma convulsion is fainted, and eclamposia is twitched, and epilepsy is gone mad, and has a headache dizzy, cataract, maculae caused by violent heat pathogen, carbuncle sore tumefacting virus.
Folium Mori: for anemopyretic cold, headache cough.The sweet cold light weight of this product, light clear evacuates, and is longer than wind-heat dissipating, again can clearing away lung-heat to relieve cough, thus be usually used in anemopyretic cold or epidemic febrile disease from the beginning of, attack of pathogenic warmth in the lung, heating, headache, the diseases such as cough.
Flos Chrysanthemi: there is loose wind heat clearing away, effect of suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Caulis Polygoni Multiflori: effect: nourish heart, calms the nerves, and dredging collateral dispels the wind, and cures mainly: control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.
Fructus Atriplicis Sibiricae: bitter, pungent, flat, enter Liver Channel.Suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.For dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.
Ramulus Mori: taste is poor, is slightly cold, nontoxic.Mulberry head: bitter in the mouth, cold in nature, nontoxic.Wind-damp dispelling; The meridian dredging; Row aqueous vapor.Main air pain of dampness syndrome; Apoplexy and hemiplegia; Edema foot gas; Human body pruritus due to wind pathogen.For takeing on arm, joint aches is numb.
Rhizoma Arisaematis: Rhizoma Arisaematis commonly uses Rhizoma Zingiberis Recens or bile is concocted, then use after storage, therefore claim Arisaema Cum Bile.: bitter, micro-pungent, cool.Return lung, liver, spleen channel.Function cures mainly: removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.
Fructus Pruni persicae immaturus: sour, bitter is flat.Return lung, Liver Channel.Arresting sweating arresting seminal emission, promoting blood circulation and hemostasis, pain relieving.For night sweat, seminal emission, cardiac and abdominal pain, spits blood, gestation hemorrhage.
Rice wine: have good mitigation to neurasthenia, absentminded, the depressed disease such as forgetful, rice wine can also help blood circulation, enhances metabolism, and has effect of blood-enriching face-nourishing, relaxing muscles and tendons and activating QI and blood in the collateral, building body and life lengthening.
Chinese medicine composition scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected materials is all Chinese medicine material, without any side effects;
2, this prescription meets Chinese medicine principle and migraine, affected nerves of patients with trigeminal neuralgia body and mind feature completely, under the prerequisite of general principle, can have different prescription according to different crowd, and function is different.
3, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 treats migraine, prosopalgic Chinese medicine composition, gets the raw materials ready (getting 10g for every part) by following weight parts: Fructus Viticis 20 parts, Cornu Saigae Tataricae 3 parts, 50 parts, Folium Mori, Flos Chrysanthemi 50 parts, Caulis Polygoni Multiflori 20 parts, Pericarpium Citri Reticulatae 50 parts, Fructus Atriplicis Sibiricae 20 parts, Ramulus Mori 20 parts, Arisaema Cum Bile 20 parts, Fructus Pruni persicae immaturus 20 parts and 100 parts, rice wine.
The preparation method of above-mentioned treatment migraine, prosopalgic Chinese medicine composition:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 1 day, take out stand-by;
(2) step (1) gains are placed on tile dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 80 mesh sieves, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving, makes Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 60 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite to be fried open, turn 30 minutes at a simmer, filter:
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor is obtained concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1 hour, obtain drying object, dry at temperature is 70 DEG C;
(7) gained drying object is measured according to 0.3g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Typical case one: Liu XX, man 32 years old, Heze City, Shandong Province personage, cadre at their posts.Patient's readme: had on the right side of recurrent exerbation and had a headache the time of 8 years, because operating pressure larger right side headache increases the weight of to have a surplus for 3 years, in recent year, headache is on average shown effect 1-2 time weekly, each lasting 4 hours, severe headache during outbreak, companion's Nausea and vomiting, without speech, limb function and disturbance of consciousness, oral rotundine, Ergotamine heterodyne.Health check-up: blood pressure 130/80mmhg, cranial nerve is normal, and neck is soft, greasy in tongue, rolling pulse.Electroencephalogram is normal, head CT and magnetic resonance examination without exception.Diagnosis: migraine.In this time in 1 year, patient says the doctor seen many times, eats much famous and precious medicine, but effect is not fine, listens friend to say traditional Chinese medicine composition for treating migraine effect of the present invention very good in November, 2011.Just 4 courses for the treatment of have been bought.
Take the embodiment of the present invention 1 gained Chinese medicine composition and with the use of embodiment 1 gained Chinese medicinal pillow, after 1 course for the treatment of, patient's sensation pain when falling ill is so inviolent, the symptoms such as Nausea and vomiting are not had yet, after continuing to take 2 courses for the treatment of, basic malaise symptoms disappears, the state of an illness is basicly stable, continues to take to do 1 course for the treatment of and consolidates, without recurrence after drug withdrawal.
Embodiment 2 treats migraine, prosopalgic Chinese medicine composition, gets the raw materials ready (getting 20g for every part) by following weight parts: Fructus Viticis 40 parts, Cornu Saigae Tataricae 7 parts, 150 parts, Folium Mori, Flos Chrysanthemi 150 parts, Caulis Polygoni Multiflori 40 parts, Pericarpium Citri Reticulatae 150 parts, Fructus Atriplicis Sibiricae 40 parts, Ramulus Mori 40 parts, Arisaema Cum Bile 40 parts, Fructus Pruni persicae immaturus 40 parts and 200 parts, rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 5 days, take out stand-by;
(2) step (1) gains are placed on tile dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 120 mesh sieves, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving, makes Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 100 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite to be fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor is obtained concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 2 hours, obtain drying object, dry at temperature is 90 DEG C;
(7) gained drying object is measured according to 0.7g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Typical case two: yellow XX, man 28 years old.Henan Zhumadian personage, certain high school teachers.3 years causes be duration headache unbearably, see a doctor in outpatient service in July, 2010.Patient's readme was begun before 3 years to occur having a headache in Zuo Temporal side, and from the beginning of slightly, pain is done in paroxysm, and spring, outbreak was more acute, and oral indometacin sheet can be alleviated, shows effect frequent, monthly show effect 4-5 time over 1 year, at every turn lasting 1-2 days, to make front aethomma dim spot, depending on special fuzzy; During outbreak, twinge is fought sense, companion's Nausea and vomiting time heavy, and be on tenterhooks, local hospital is examined as angioneurotic headache, to wheat clothes peace preparation, first can alleviate, then gradually lose efficacy.Nearly March has a headache on the left of paroxysmal, and head sinks swollen, pain as being stabbed time heavy, and sore spot is fixing not to be moved, and still has sense of fighting during outbreak, companion's Nausea and vomiting.Clothes medicine-feeding is invalid.Have a medical check-up: sanity, spirit is poor, and cranial nerve is normal, and neck is soft, and myasthenia of limbs, muscular tension are normal, and bilateral pathology levies feminine gender.Thin white fur of tongue, deep-thready pulse string.Head CT and magnetic resonance examination normally, are diagnosed as: the migraine caused by nervi trigeminus.
Give the oral embodiment of the present invention 2 resulting composition and with the use of the embodiment of the present invention 2 gained Chinese medicinal pillow, after 3 courses for the treatment of, patient's self-induction attack times obviously reduces, after continuing to have taken 3 courses for the treatment of, substantially do not recur, during recurrence, pain degree alleviates, decreased duration, continue again to take 1 course for the treatment of, cure completely, not having Headache attacks 1 year more so far.
Embodiment 3 treats migraine, prosopalgic Chinese medicine composition, gets the raw materials ready (getting 30g for every part) by following weight parts: Fructus Viticis 25 parts, Cornu Saigae Tataricae 4 parts, 80 parts, Folium Mori, Flos Chrysanthemi 80 parts, Caulis Polygoni Multiflori 25 parts, Pericarpium Citri Reticulatae 80 parts, Fructus Atriplicis Sibiricae 25 parts, Ramulus Mori 25 parts, Arisaema Cum Bile 25 parts, Fructus Pruni persicae immaturus 25 parts and 130 parts, rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 2 days, take out stand-by;
(2) step (1) gains are placed on tile dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 90 mesh sieves, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving, makes Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 70 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite to be fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor is obtained concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1.3 hours, obtain drying object, dry at temperature is 75 DEG C;
(7) gained drying object is measured according to 0.4g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Typical case three: patient: king XX, female, 45 years old, Jiangzhou, Qingdao personage, peasant.Left side of head pain was there is without obvious inducement before 1 year, every day substantially can timing pain, the time of general pain can not be oversize, pain is got up just as pinprick, people is on tenterhooks, can not works, sometimes can not taking food of pain, remove examination in hospital: doctor, according to basic situation, is diagnosed as: trigeminal neuralgia.Owing to being that farmers' family's condition is not flush with money, doctor advised patient takes Chinese medicine composition of the present invention.
Take the embodiment of the present invention 3 gained Chinese medicine composition and with the use of embodiment 3 gained Chinese medicinal pillow, after 3 courses for the treatment of, patient's readme, the pain of all timing outbreak former every day, within 3 days, remained dormant, after continuing again to take 1 course for the treatment of, malaise symptoms disappears substantially.
Embodiment 4 treats migraine, prosopalgic Chinese medicine composition, gets the raw materials ready (getting 40g for every part) by following weight parts: Fructus Viticis 35 parts, Cornu Saigae Tataricae 6 parts, 120 parts, Folium Mori, Flos Chrysanthemi 120 parts, Caulis Polygoni Multiflori 35 parts, Pericarpium Citri Reticulatae 120 parts, Fructus Atriplicis Sibiricae 35 parts, Ramulus Mori 35 parts, Arisaema Cum Bile 35 parts, Fructus Pruni persicae immaturus 35 parts and 180 parts, rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 4 days, take out stand-by;
(2) step (1) gains are placed on tile dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 110 mesh sieves, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving, makes Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 90 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite to be fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor is obtained concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1.7 hours, obtain drying object, dry at temperature is 85 DEG C;
(7) gained drying object is measured according to 0.6g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Embodiment 5 treats migraine, prosopalgic Chinese medicine composition, gets the raw materials ready (getting 50g for every part) by following weight parts: Fructus Viticis 30 parts, Cornu Saigae Tataricae 5 parts, 100 parts, Folium Mori, Flos Chrysanthemi 100 parts, Caulis Polygoni Multiflori 30 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Atriplicis Sibiricae 30 parts, Ramulus Mori 30 parts, Arisaema Cum Bile 30 parts, Fructus Pruni persicae immaturus 30 parts and 150 parts, rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 3 days, take out and be placed on tile and dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 100 mesh sieves, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving, makes Chinese medicinal pillow; Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 80 mesh sieves; Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite be fried open, turn 30 minutes at a simmer, filter; Gained filtrate is heated to boiling, continues to filter after 1 hour, concentrating filter liquor is being obtained concentrated solution to 1/2 of original volume; Gained smalls is poured in the concentrated solution of gained, fully stirs into thick paste; Thick paste is dried 1.5 hours, obtain drying object, dry at temperature is 80 DEG C; By gained drying object according to the metering of 0.5g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Test example 1 embodiment 5 gained treatment migraine, prosopalgic Chinese medicine composition clinical practice: in June, 2008 in December ,-2012, screen 120 routine patients in 4 hospitals, wherein women 58 example, male 62 example, oldest 72 years old, minimal ages 18 years old, 50 years old mean age.Before test 2 weeks, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine (conventional medication such as aspirin, indometacin, Phenylbutazone, acetaminophen).Using method is: tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams, within 10 days, is a course for the treatment of, rests the head on Chinese medicinal pillow of the present invention in bed.Curative effect situation criterion: cure: take embodiment 5 gained tablet and coordinate a course for the treatment of of embodiment 5 gained Chinese medicinal pillow, malaise symptoms has clear improvement, and pain disappears substantially; Effective: take embodiment 5 gained tablet and coordinate a course for the treatment of of embodiment 5 gained Chinese medicinal pillow, malaise symptoms makes moderate progress, and pain alleviates to some extent; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 18-72 year migraine, affected nerves of patients with trigeminal neuralgia therapeutic outcome
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
The present invention selects Fructus Viticis, Cornu Saigae Tataricae, Folium Mori, Flos Chrysanthemi, Caulis Polygoni Multiflori, Pericarpium Citri Reticulatae, Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile, Fructus Pruni persicae immaturus and rice wine to carry out compatibility, produce synergism after making these drug regimens, can more effectively treat migraine, trigeminal neuralgia.In side, Folium Mori, Flos Chrysanthemi, Pericarpium Citri Reticulatae and rice wine master are at blood circulation promoting and blood stasis dispelling, hypnotic; Fructus Viticis, Cornu Saigae Tataricae, Caulis Polygoni Multiflori, Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus master at expelling wind and cold, understand things pain-stopping.All medicines share, and invigorate blood circulation and can yin nourishing, blood stasis dispelling and just do not hinder, and have one's ideas straightened out and QI invigorating of holding concurrently, sensible and pain relieving therefore can obtain good therapeutic effect.Take 10 days, more than 53% feel takes a turn for the better to some extent, and malaise symptoms improves, and pain alleviates to some extent; Take 20 days, more than 72% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and the mental status is good; Take 30 days, more than 97% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, head CT and magnetic resonance examination display normal, some patients self-induction is fully recovered.Take more than 30 days in experimental group, effective percentage can reach 93%, and matched group is only 76%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (15)
1. treat the preparation method of migraine, prosopalgic Chinese medicine composition for one kind, it is characterized in that, take off the crude drug stating weight proportion: Fructus Viticis 20-40 part, Cornu Saigae Tataricae 3-7 part, Folium Mori 50-150 part, Flos Chrysanthemi 50-150 part, Caulis Polygoni Multiflori 20-40 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Atriplicis Sibiricae 20-40 part, Ramulus Mori 20-40 part, Arisaema Cum Bile 20-40 part, Fructus Pruni persicae immaturus 20-40 part and rice wine 100-200 part; Step is as follows:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine soak 1-5 days, take out stand-by;
(2) step (1) gains are placed on tile dry with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 80-120 mesh sieve, Flos Chrysanthemi is put into medicated pillow together with the smalls after sieving, makes Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 60-100 mesh sieve;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in intense fire in marmite to be fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor is obtained concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1-2 hour, obtains drying object, dry at temperature is 70-90 DEG C;
(7) gained drying object is measured according to 0.3-0.7g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
2. preparation method according to claim 1, it is characterized in that, each raw material is as follows: Fructus Viticis 25-35 part, Cornu Saigae Tataricae 4-6 part, Folium Mori 80-120 part, Flos Chrysanthemi 80-120 part, Caulis Polygoni Multiflori 25-35 part, Pericarpium Citri Reticulatae 80-120 part, Fructus Atriplicis Sibiricae 25-35 part, Ramulus Mori 25-35 part, Arisaema Cum Bile 25-35 part, Fructus Pruni persicae immaturus 25-35 part and rice wine 130-180 part.
3. preparation method according to claim 1, it is characterized in that, each raw material is as follows: Fructus Viticis 30 parts, Cornu Saigae Tataricae 5 parts, 100 parts, Folium Mori, Flos Chrysanthemi 100 parts, Caulis Polygoni Multiflori 30 parts, Pericarpium Citri Reticulatae 100 parts, Fructus Atriplicis Sibiricae 30 parts, Ramulus Mori 30 parts, Arisaema Cum Bile 30 parts, Fructus Pruni persicae immaturus 30 parts and 150 parts, rice wine.
4. preparation method according to claim 1, is characterized in that: step (1) soaks 2-4 days in rice wine.
5. preparation method according to claim 4, is characterized in that: step (1) is soaked 3 days in rice wine.
6. preparation method according to claim 1, is characterized in that: step (2) crosses 90-110 mesh sieve.
7. preparation method according to claim 6, is characterized in that: step (2) crosses 100 mesh sieves.
8. preparation method according to claim 1, is characterized in that: step (3) crosses 70-90 mesh sieve.
9. preparation method according to claim 8, is characterized in that: step (3) crosses 80 mesh sieves.
10. preparation method according to claim 1, is characterized in that: thick paste is dried 1.3-1.7 hour by step (6).
11. preparation methoies according to claim 10, is characterized in that: thick paste is dried 1.5 hours by step (6).
12. preparation methoies according to claim 1, is characterized in that: step (6) is dry at temperature is 75-85 DEG C.
13. preparation methoies according to claim 12, is characterized in that: step (6) is dry at temperature is 80 DEG C.
14. preparation methoies according to claim 1, is characterized in that: the dosage form of step (7) gained tablet is 0.4-0.6g/ sheet.
15. preparation methoies according to claim 14, is characterized in that: the dosage form of step (7) gained tablet is 0.5g/ sheet.
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| CN1169292A (en) * | 1996-06-21 | 1998-01-07 | 刘庆海 | Preparation of traditional Chinese herbs for treatment of cephalagra |
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| CN1169292A (en) * | 1996-06-21 | 1998-01-07 | 刘庆海 | Preparation of traditional Chinese herbs for treatment of cephalagra |
| CN102068624A (en) * | 2009-11-23 | 2011-05-25 | 史海霞 | Traditional Chinese medicine for treatment of hemicrania |
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| 张燕.张良骥主任医师论治头痛7方及运用经验.《中华中医药学刊》.2008,第26卷(第4期),698-699. * |
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