CN105381408A - Compound preparation for treating trigeminal neuralgia and preparation method thereof - Google Patents
Compound preparation for treating trigeminal neuralgia and preparation method thereof Download PDFInfo
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- CN105381408A CN105381408A CN201510935477.3A CN201510935477A CN105381408A CN 105381408 A CN105381408 A CN 105381408A CN 201510935477 A CN201510935477 A CN 201510935477A CN 105381408 A CN105381408 A CN 105381408A
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Abstract
The invention discloses a compound preparation for treating trigeminal neuralgia. The compound preparation is prepared from 20-45 parts by weight of radix curcumae longae, 20-45 parts by weight of Daphne odora Thumb., 20-45 parts by weight of myrrh, 20-45 parts by weight of herba andrographitis, 30-50 parts by weight of herb of glabrous sarcandra, 30-50 parts by weight of reddish orange, 30-50 parts by weight of semen strychni, 1-5 parts by weight of scorpion and 1-5 parts by weight of herb of gold stargrass. The compound preparation has the effects of dispelling wind and removing obstruction in the meridians, relaxing muscles and stimulating blood circulation, supporting body resistance, reinforcing qi and nourishing blood, promoting blood circulation to remove blood stasis, and relieving pain, and has substantial and definite pesticide effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat prosopalgic compound preparation and preparation method thereof.
Background technology
Trigemino-vascular theory: it is trigemino-vascular complex (trigeminovascularcomplex) that this theory dissects reason basis.Intracranial Hyperalgesia tissue is as cerebrovascular, meningovascular, venous sinus, and its Perivascular nerve fiber fiber enters trigeminal ganglion with ophthalmic branch of trigeminal nerve, or enters 1,2 cervical nerves (C1, C2) roots afterwards from Posterior fossa; Both are after trigeminal ganglion and C1, C2 spinal ganglion change unit, and send nerve fiber to nervi trigeminus neck complex (trigeminocervicalcomplex), the latter is made up of spinal nucleus of trigeminal nerve tail end and C1, C2 relief angle; Nervi trigeminus neck complex sends nerve fiber, after brain stem intersects, be projected to thalamus.Surrounding's Theory of Pain Mechanism of this theory is thought, trigeminal ganglion infringement may be the neural basal that migraine is produced.When after trigeminal ganglion and fiber irriate thereof, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), calcitonin-gene-related peptide (CGRP) and other neuropeptides can be caused to discharge to be increased.These active substances act on Neighbouring Brain blood vessel wall, can cause vasodilation and occur pulsatile headache, vascular permeability also can be made to increase, plasma protein extravasation, produce aseptic inflammation, and stimulate pain sensation fiber to import maincenter into, form vicious cycle.
Trigeminal neuralgia is modal cranial nerve diseases, and with the violent pain of the paroxysmal of recurrent exerbation in a side surface part nervi trigeminus areal area for main manifestations, the sickness rate 52.2/10 ten thousand of domestic statistics, female is slightly more than man, and sickness rate can increase with the age.Trigeminal neuralgia is mainly in middle-aged and elderly people, R)L.The feature of this disease is: in Head And Face nervi trigeminus distributed areas, and morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking.Pain lasts several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.
Trigeminal neuralgia can be divided into constitutional (symptomatic) trigeminal neuralgia and the large class of secondary trigeminal neuralgia two, and wherein primary trigeminal neuralgia is more common.Primary trigeminal neuralgia refers to have clinical symptoms, but applies various inspection and do not find and relevant organic disease of falling ill.Secondary trigeminal neuralgia is apart from clinical symptoms, and clinical and imaging examination can find that organic disease is as tumor, inflammation, vascular malformation etc. simultaneously.Secondary trigeminal neuralgia is more common in below 40 years old, adolescence, and usually do not have trigger point, risk factor is not obvious, and pain is often in persistence, and some patients can find to show with other of primary disease.Brain CT, MRI, nasopharynx part biopsy etc. help diagnosis.
In the prosopalgic medicine of existing treatment, publication number CN102357238A(application number 201110328707.1) Chinese patent literature disclose one and treat prosopalgic Chinese medicine composition, be made up of the raw material of following weight: Fructus Evodiae 8-10 gram, Radix Ginseng 9-15 gram, Rhizoma Zingiberis Recens 9-15 gram, Fructus Jujubae 9-15 gram, Radix Asparagi 4-8 gram, Radix Ophiopogonis 4-8 gram, Rhizoma Cimicifugae 1-5 gram, Bidens paruiflora Willd. 4-8 gram, Pericarpium Papaveris 4-8 gram, Semen Persicae mud 1-3 gram, Flos Carthami 1-3 gram, Semen Pruni Salicinae 8-10 gram, Flos daphnes odorae 4-6 gram.Application publication number CN103349692A(application number 201310192847.X) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of migraine, Trigeminal Neuralgia, choose Radix Ginseng 60-180g, Pericarpium Citri Reticulatae 60-180g, Flos Carthami 60-180g, Rhizoma Chuanxiong 80-240g, Rhizoma Curcumae Longae 80-240g processed, Radix Saposhnikoviae 80-240g, Radix Angelicae Pubescentis 80-240g, Caulis Sinomenii 90-270g, Fructus Tritici Levis 90-270g, Semen Ziziphi Spinosae 30-120g be prepared from.
As can be seen here, Chinese medicine achieves good curative effect in treatment primary disease, but also there are some problems: clinically to activating blood circulation to dissipate blood stasis and dredge the collateral, expelling wind and cold, understand things pain-stopping is desirable not enough, has much room for improvement to improving the misery that trigeminal neuralgia brings.
Summary of the invention
The invention provides one for above problem and treat prosopalgic compound preparation, the migraine that this compound preparation proves to cause trigeminal neuralgia and a variety of causes by clinical treatment for many years, headache, insomnia, vomiting have good therapeutic effect, compound preparation of the present invention has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons to promote blood circulation, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, promoting blood circulation, removing blood stasis and relieving pain, has the advantage that Be very effective, drug effect are definite.
The present invention is achieved through the following technical solutions:
One treats prosopalgic compound preparation, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Curcumae Longae 20-45 part, Flos daphnes odorae 20-45 part, Myrrha 20-45 part, Herba Andrographis 20-45 part, Herba Sarcandrae 30-50 part, Exocarpium Citri Rubrum 30-50 part, Semen Strychni 30-50 part, Scorpio 1-5 part, Herba hypoxis aureae 1-5 part.
Described compound preparation, preferred scheme is: its preferred version takes off the primary raw material stating weight proportion to be prepared from: Rhizoma Curcumae Longae 25-40 part, Flos daphnes odorae 25-40 part, Myrrha 25-40 part, Herba Andrographis 25-40 part, Herba Sarcandrae 35-45 part, Exocarpium Citri Rubrum 35-45 part, Semen Strychni 35-45 part, Scorpio 2-4 part, Herba hypoxis aureae 2-4 part.
Described compound preparation, the scheme be more preferably is: its preferred plan takes off the primary raw material stating weight proportion to be prepared from: 30 parts, Rhizoma Curcumae Longae, Flos daphnes odorae 30 parts, Myrrha 30 parts, Herba Andrographis 30 parts, Herba Sarcandrae 35 parts, Exocarpium Citri Rubrum 35 parts, Semen Strychni 35 parts, Scorpio 3 parts, Herba hypoxis aureae 3 parts.
The preparation method of above-mentioned compound preparation, step is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 10-30 minute, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 2-9 minute, takes out, and sieve removes wheat bran, spreading for cooling;
(2) soaked completely by Herba hypoxis aureae vinegar to be placed on food steamer for 10-30 minute and steam 4-8 minute, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 6-12 minute, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 22-32 minute, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 7-13 minute, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 13-18 minute, dry, can capsule according to the processing technique processing of capsule by gains.
Described preparation method, preferred scheme is: the slightly vexed 15-25 minute of step (1), gets wheat bran and puts in hot pot, fries to sliding sharp state, drop into Scorpio, constantly stir-fry 4-7 minute (preferably slightly vexed 20 minutes, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 6 minutes).
Described preparation method, preferred scheme is: step (2) is soaked within 15-25 minute, to be placed on food steamer completely with vinegar and steamed 5-7 minute (preferably soak completely within 20 minutes, to be placed on food steamer with vinegar and steam 6 minutes).
Described preparation method, preferred scheme is: step (3) is fried 8-10 minute (preferably frying 9 minutes).
Described preparation method, preferred scheme is: step (4) big fire is boiled, and turns slow fire boiling 26-28 minute (preferred big fire is boiled, and turns slow fire boiling 27 minutes).
Described preparation method, preferred scheme is: step (4) heats and decocts 9-11 minute (preferably heat decoct 10 minutes).
Described preparation method, preferred scheme is: step (5) dries 15-17 minute slowly, dry (preferably drying 16 minutes slowly, dry).
Using method: for making the present invention reach optimum therapeuticing effect, take after 1 hour after meal, 3 times on the one, each 2-4 grain, warm water delivery service.
This compound preparation, to trigeminal neuralgia Be very effective, has relaxing muscles and tendons to promote blood circulation, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, the feature of promoting blood circulation, removing blood stasis and relieving pain.
A kind of pharmacological effect for the treatment of each crude drug of prosopalgic compound preparation of the present invention is:
Rhizoma Curcumae Longae: Rhizoma Curcumae Longae Musales, Zingiberaceae, Curcuma herbaceos perennial, plant height 1 ~ 1.5m, rhizome is very flourishing, and root is sturdy, and end expands in tuber; Blade Long Circle or ellipse, the short gradually point in leaf top; Avette or the Long Circle of bract, light green, top is blunt, and corolla is faint yellow; August at florescence.Rhizoma Curcumae Longae energy circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm arthralgia pain, unbearably pained, puerperal blood pain, skin ulcer tinea onset, menoxenia, amenorrhea, traumatic injury.Yellow food colour can be extracted again; Contained curcumin can perform an analysis chemical reagent.
Flos daphnes odorae: compile according to " Chinese medicine voluminous dictionary ", the root of winter daphne, stem, leaf, Hua Junke are used as medicine.Its property is sweet nontoxic, and have heat clearing away solution car, antiinflammatory goes to swell, the function of blood circulation and promoting silt, and conventional fresh leaf among the people is mashed " to be controlled throat kind pain, toothache, blood furuncle furuncle, ooze wineshop sassafras be coated with innominate toxic swelling and various dermatosis, expelling wind and removing dampness, promoting blood circulation and stopping pain for flower.For rheumatic arthritis, sciatica, pharyngitis, toothache, breast carcinoma is from the beginning of, traumatic injury.
Myrrha: be olive subject plant Herba Violae tree CommiphoramyrrhaEngl. or the dry resin breathing out Herba Violae tree CommiphoramolmolEngl..Be divided into natural Myrrha and gum opoponax.Be distributed in the ground such as Somalia, Ethiopia and south, the Arabia Peninsula.There is dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation.Be usually used in obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation ， mass in the abdomen is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the diseases such as carbuncle skin infection.
Herba Andrographis: Herba Andrographis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.
Herba Sarcandrae: another name: synthetism chu lan tree, Herba Pileae Scriptae, Psychotria rubra (Lour.) Poir. flower, Herba Pileae Scriptae, ring tea, synthetism lotus, kwan-yin tea, Ramulus Sambuci Williamsii, Herba Pileae Scriptae, refute save tea, duck foot joint, mountain Radix Achyranthis Bidentatae, Chloranthus spicatus Mak, veronica, Baptisia, Xue Shicha, Cortex torricelliae tiliifoliae, Rhizoma seu Herba Elatostematis stewardii, copper foot Radix Clematidis, Herba Pileae Scriptae, joint bone tea, synthetism lotus, bamboo tea.Function cures mainly the removing toxic substances of anti-inflammation heat clearing and blood cooling, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.Hyperactivity of toxic heat patient is belonged to for pneumonia, appendicitis, cellulitis; And rheumatic arthralgia, injury from falling down, tumor auxiliary treatment.
Exocarpium Citri Rubrum: acrid in the mouth, hardship, warm in nature.Gui Jing: return lung, spleen channel.Effect: regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm.Cure mainly: for cough with copious phlegm, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
Semen Strychni: containing alkaloid, is mainly brucine (strychnine) and strychnine, and the vomicine containing trace, pseudostrychnine, pseudobrucine, slave cuts down new alkali, and scholar bends new alkali and fatty oil, protein, chlorogenic acid etc.Nature and flavor: bitter, temperature; Very toxic.Return liver, spleen channel.Function cures mainly: excited stomach invigorating, detumescence poison, removing heat from blood.Cure mainly numb limbs and tense tendons, paralysis, inappetence, mass in the abdomen, carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain.
Scorpio: pungent, flat.Gui Jing: return Liver Channel.Effect: endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Cure mainly: for liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Herba hypoxis aureae: another name: little Rhizoma Curculiginis, little Jin lock prunus mume (sieb.) sieb.et zucc., Herba Allii bulleyani, imperial kidney, unipods Rhizoma Curculiginis, and sweet, micro-pungent, warm, function cures mainly: warming the kidney to invigorate YANG; Regulating QI to relieve pain.Main lumbago due to renal deficiency; Sexual impotence; Insomnia; Colic of cold type is suffered from abdominal pain.
The present invention is a kind of treats prosopalgic compound preparation for the above-mentioned defect at other treatment trigeminal neuralgia medicine, this product is on the basis of summing up forefathers' experience, go through clinical research for many years, adopt natural Chinese medicines unique formula and technique to refine to form, this product includes abundant plant thing active component, can directly act on affected part.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1:one treats prosopalgic compound preparation, gets the raw materials ready (getting 10g for every part): Rhizoma Curcumae Longae 20, Flos daphnes odorae 20, Myrrha 20, Herba Andrographis 20, Herba Sarcandrae 30, Exocarpium Citri Rubrum 30, Semen Strychni 30, Scorpio 1, Herba hypoxis aureae 1 by following weight parts.
One treats prosopalgic compound preparation, and preparation process is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 10 minutes, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 2 minutes, take out, sieve removes wheat bran, spreading for cooling;
(2) Herba hypoxis aureae vinegar is soaked completely within 10 minutes, be placed on food steamer steam 4 minutes, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 6 minutes, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 22 minutes, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 7 minutes, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 13 minutes, dry, can capsule according to the processing technique processing of capsule by gains.
model case one: poplar XX, age: 61 years old, sex: man, the workman of food factory, often be engaged in the manufacture of BABAOZHOU, often to bow capping, free work a whole morning, if noon does not have a rest, the same pain of right flank meeting pinprick, within one day, do not have a rest if worked, pain increases the weight of, feel sick, retch, feel have one gas to alter from body, pain dimensions primary limitation is at maxillar part, characteristic of pain is acupuncture sample, lancinate sample, burn sample and be interrupted pain, trigeminal neuralgia is diagnosed as through examination in hospital, owing to being afraid of to take medicine to spend in hospital, just do not treat, think that rest is not worked will turn better, as long as a job will hurt like hell, introduced by friend afterwards and heard that my institute can effect a radical cure " trigeminal neuralgia ", just the idea had a try is had in arms to our hospital, doctor sees that its suggestion of being reluctant to spending uses gained compound preparation of the present invention.
Use the present embodiment 1 gained compound preparation, treat 3 days, malaise symptoms makes moderate progress, and headache symptom obviously alleviates, and sleep therapy improves can, treat 7 days, symptom is eliminated, peace of sleeping night, and vexedly remove, strength increases, receive food can, continue use 2 days, do not occur any discomfort when patient uses, patient's self-induction is fully recovered.
embodiment 2one treats prosopalgic compound preparation, gets the raw materials ready (getting 10g for every part): Rhizoma Curcumae Longae 45, Flos daphnes odorae 45, Myrrha 45, Herba Andrographis 45, Herba Sarcandrae 50, Exocarpium Citri Rubrum 50, Semen Strychni 50, Scorpio 5, Herba hypoxis aureae 5 by following weight parts.
One treats prosopalgic compound preparation, and preparation process is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 30 minutes, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 9 minutes, take out, sieve removes wheat bran, spreading for cooling;
(2) Herba hypoxis aureae vinegar is soaked completely within 30 minutes, be placed on food steamer steam 8 minutes, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 12 minutes, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 32 minutes, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 13 minutes, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 18 minutes, dry, can capsule according to the processing technique processing of capsule by gains.
embodiment 3:one treats prosopalgic compound preparation, gets the raw materials ready (getting 10g for every part): Rhizoma Curcumae Longae 25, Flos daphnes odorae 25, Myrrha 25, Herba Andrographis 25, Herba Sarcandrae 35, Exocarpium Citri Rubrum 35, Semen Strychni 35, Scorpio 2, Herba hypoxis aureae 2 by following weight parts.
One treats prosopalgic compound preparation, and preparation process is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 15 minutes, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 4 minutes, take out, sieve removes wheat bran, spreading for cooling;
(2) Herba hypoxis aureae vinegar is soaked completely within 15 minutes, be placed on food steamer steam 5 minutes, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 8 minutes, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 26 minutes, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 9 minutes, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 15 minutes, dry, can capsule according to the processing technique processing of capsule by gains.
model case two: king XX, women, 55 years old, Linyi, Shandong Lanshan District personage, peasant, to be in kind of a ground throughout the year, feed pigs, patient home has history of hypertension, patient just Jin Guo hospital because hypertension is fallen in a swoon suddenly in 45 years old, from last year, left side was from eye socket, nose is to occipitalia paroxysmal hemicrania, patient thinks what hypertension caused, just eat antihypertensive drugs always, but started left side eye socket before 2 months, nose is to occipitalia migraine, in paroxysmal, si dol urg, be difficult to stand, dare not diet, have a meal, too loudly, nervous grade all can be brought out, really stand and do not know clearly, provincial hospital is just gone to check, be diagnosed as trigeminal neuralgia through examination in hospital to draw.
Use the present embodiment 3 gained compound preparation to treat 5 days, the symptom such as pain, insomnia obviously alleviates, and fatigue and weak also alleviates, spirit can, see effective, continue use 2 days again, be shown as normal on inspection, following the service 3 days, malaise symptoms disappears, and patient's self-induction is fully recovered.
embodiment 4:one treats prosopalgic compound preparation, gets the raw materials ready (getting 10g for every part): Rhizoma Curcumae Longae 40, Flos daphnes odorae 40, Myrrha 40, Herba Andrographis 40, Herba Sarcandrae 45, Exocarpium Citri Rubrum 45, Semen Strychni 45, Scorpio 4, Herba hypoxis aureae 4 by following weight parts.
One treats prosopalgic compound preparation, and preparation process is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 25 minutes, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 7 minutes, take out, sieve removes wheat bran, spreading for cooling;
(2) Herba hypoxis aureae vinegar is soaked completely within 25 minutes, be placed on food steamer steam 7 minutes, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 10 minutes, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 28 minutes, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 11 minutes, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 17 minutes, dry, can capsule according to the processing technique processing of capsule by gains.
embodiment 5:one treats prosopalgic compound preparation, gets the raw materials ready (getting 10g for every part): Rhizoma Curcumae Longae 30, Flos daphnes odorae 30, Myrrha 30, Herba Andrographis 30, Herba Sarcandrae 35, Exocarpium Citri Rubrum 35, Semen Strychni 35, Scorpio 3, Herba hypoxis aureae 3 by following weight parts.
One treats prosopalgic compound preparation, and preparation process is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 20 minutes, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 6 minutes, take out, sieve removes wheat bran, spreading for cooling;
(2) Herba hypoxis aureae vinegar is soaked completely within 20 minutes, be placed on food steamer steam 6 minutes, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 9 minutes, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 22-32 minute, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 10 minutes, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 16 minutes, dry, can capsule according to the processing technique processing of capsule by gains.
test exampleembodiment 5 gained treats the clinical practice of prosopalgic compound preparation: in June, 2010 in December ,-2014, screen 120 routine patients in 4 hospitals, wherein women 58 example, male 62 example, oldest 72 years old, minimal ages 18 years old, 60 years old mean age, before test, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups, experimental group and matched group at random, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine.
Using method is: for making the present invention reach optimum therapeuticing effect, take after 1 hour after meal, 3 times on the one, each 2-4 grain, warm water delivery service.
Curative effect situation criterion: cure: after taking this product, migraine, headache, insomnia, vomiting degree are obviously improved, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: after taking this product, migraine, headache, insomnia, vomiting degree are improved, and malaise symptoms alleviates or partial disappearance, and energy and muscle power strengthen; Invalid: after taking this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 18-72 year affected nerves of patients with trigeminal neuralgia therapeutic outcome
| Experimental group | Matched group | |
| Number of cases | 100 | 20 |
| Male's number of cases | 52 | 10 |
| Women's number of cases | 48 | 10 |
| Age (year) | 38-72 | 38-72 |
| Clinical cure number of cases | 72 | 5 |
| Effective number of cases | 27 | 11 |
| Invalid number of cases | 1 | 4 |
| Total effective rate | 99% | 80% |
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
The present invention selects Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum, Semen Strychni, and Scorpio and Herba hypoxis aureae etc. carry out compatibility, produces synergism after making these drug regimens, more effectively can treat trigeminal neuralgia.Take 3 days, more than 53% feel takes a turn for the better to some extent, and malaise symptoms improves; Take 6 days, more than 72% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and the mental status is good; Take 9 days, more than 97% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit is very good, and some patients self-induction is fully recovered.Take more than 9 days in experimental group, effective percentage can reach 93%, and matched group is only 76%.
Claims (10)
1. the prosopalgic compound preparation for the treatment of, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Rhizoma Curcumae Longae 20-45 part, Flos daphnes odorae 20-45 part, Myrrha 20-45 part, Herba Andrographis 20-45 part, Herba Sarcandrae 30-50 part, Exocarpium Citri Rubrum 30-50 part, Semen Strychni 30-50 part, Scorpio 1-5 part, Herba hypoxis aureae 1-5 part.
2. compound preparation according to claim 1, it is characterized in that: its preferred version takes off the primary raw material stating weight proportion to be prepared from: Rhizoma Curcumae Longae 25-40 part, Flos daphnes odorae 25-40 part, Myrrha 25-40 part, Herba Andrographis 25-40 part, Herba Sarcandrae 35-45 part, Exocarpium Citri Rubrum 35-45 part, Semen Strychni 35-45 part, Scorpio 2-4 part, Herba hypoxis aureae 2-4 part.
3. compound preparation according to claim 1, is characterized in that: its preferred plan takes off the primary raw material stating weight proportion to be prepared from: 30 parts, Rhizoma Curcumae Longae, Flos daphnes odorae 30 parts, Myrrha 30 parts, Herba Andrographis 30 parts, Herba Sarcandrae 35 parts, Exocarpium Citri Rubrum 35 parts, Semen Strychni 35 parts, Scorpio 3 parts, Herba hypoxis aureae 3 parts.
4. the preparation method of the prosopalgic compound preparation of the treatment according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Scorpio and jowar wine are mixed thoroughly, slightly vexed 10-30 minute, get wheat bran and put in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 2-9 minute, takes out, and sieve removes wheat bran, spreading for cooling;
(2) soaked completely by Herba hypoxis aureae vinegar to be placed on food steamer for 10-30 minute and steam 4-8 minute, taking-up is dried, and obtains vinegar Herba hypoxis aureae;
(3) be placed in preheated pot by Rhizoma Curcumae Longae, Flos daphnes odorae, Myrrha, Herba Andrographis, Herba Sarcandrae, Exocarpium Citri Rubrum and Semen Strychni, fry 6-12 minute, drying in the air coolly is ground into smalls, sieves stand-by;
(4) step (1) gained Scorpio (parched) and step (2) gained vinegar Herba hypoxis aureae are placed in light salt brine, big fire is boiled, turn slow fire boiling 22-32 minute, with strainer, Scorpio (parched) and vinegar Herba hypoxis aureae are taken out, filtrate continues heating, is placed on by step (3) gained smalls in the filtrate of continuing heating, heats and decoct 7-13 minute, put into dextrin and Mel, continue to stir into thick paste;
(5) by step (4) gained thick paste, slow baking 13-18 minute, dry, can capsule according to the processing technique processing of capsule by gains.
5. preparation method according to claim 4, it is characterized in that: the slightly vexed 15-25 minute of step (1), getting wheat bran puts in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 4-7 minute (preferably slightly vexed 20 minutes, getting wheat bran puts in hot pot, fry to sliding sharp state, drop into Scorpio, constantly stir-fry 6 minutes).
6. preparation method according to claim 4, is characterized in that: step (2) is soaked within 15-25 minute, to be placed on food steamer completely with vinegar and steamed 5-7 minute (preferably soak completely within 20 minutes, to be placed on food steamer with vinegar and steam 6 minutes).
7. preparation method according to claim 4, is characterized in that: step (3) is fried 8-10 minute (preferably frying 9 minutes).
8. preparation method according to claim 4, is characterized in that: step (4) big fire is boiled, and turns slow fire boiling 26-28 minute (preferred big fire is boiled, and turns slow fire boiling 27 minutes).
9. preparation method according to claim 4, is characterized in that: step (4) heats and decocts 9-11 minute (preferably heat decoct 10 minutes).
10. preparation method according to claim 4, is characterized in that: step (5) dries 15-17 minute slowly, dry (preferably drying 16 minutes slowly, dry).
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