CN103610858A - Traditional Chinese medicine composition for treating migraine and prosopalgia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating migraine and prosopalgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating migraine and prosopalgia, which is prepared from the following bulk drugs in parts by weight: 20-40 parts of fructus viticis, 3-7 parts of antelope horns, 50-150 parts of mulberry leaves, 50-150 parts of chrysanthemum, 20-40 parts of tuber fleeceflower stems, 50-150 parts of dried orange peel, 20-40 parts of tribulusterrestris, 20-40 parts of ramulus mori, 20-40 parts of arisaema with bile, 20-40 parts of fructus persicae immaturus, and 100-200 parts of rice wine. The traditional Chinese medicine composition disclosed by the invention has the characteristics of simple preparation method, easiness for taking, convenience for carrying, and easiness for long-term taking; the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis and dredge collaterals, expelling wind, removing cold, promoting the restoration of consciousness, and relieving pain.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of migraine, prosopalgic Chinese medicine composition and preparation method thereof for the treatment of.
Background technology
Migraine (migraine) is clinical modal primary headache type; it is clinical that to take the headache of ictal middle severe, the sample of beating be main manifestations; headache mostly is inclined to one side side; general lasting 4～72 hours; can be with feeling sick, vomitting; light, sound stimulate or daily routines all can increase the weight of headache, and quiet environment, rest can be alleviated headache.Migraine is a kind of common chronic neural blood vessel illness, and a lot of diseases are in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, men and women's Proportion of patients is about 1: 2～and 3, in crowd, prevalence is 5%～10%, often has genetic background.
Migrainous pathogenesis is still not fully aware of, mainly contains at present following theory:
Blood vessel theory: traditional blood vessel theory thinks that migraine is constitutional angiopathy.Intracranial vessel shrinks and to cause migraine aura symptom, outer, the intracranial vessel expansion of cranium subsequently, and blood vessel surrounding tissue produces vasoactive polypeptide and causes aseptic inflammation to cause the headache of pulsation.Carotid artery and superficial temporal artery local compression, vasoconstrictor peptide can be alleviated stage of attack headache as Ergotamine and support this theory.The clinical practices such as neuroimaging development TCD, PET, have further developed blood vessel source theory, and proposing tendency type is the same disease that vasospasm degree is different with Migraine without aura.Various neurons are different to the sensitivity of ischemia, the appearance of premonitory symptom is due to vasoconstriction, after blood flow reduces, the neuron of visual cortex is the most responsive to ischemia, therefore visual aura occurs at first, then increasing neuronal function is affected, then engenders other neurological symptoms such as finger is numb.
Neural theory: when neural theory is thought migraine, the variation of function of nervous system is primary, and the variation of blood flow is secondary.Migraine aura is by autgmentability cortex, to suppress (cortical spreading depressing, CSD) to cause.CSD refers to the neuroelectricity activity inhibition zone that originates from brain rear portion cortex (occipital lobe) that various destructive stimuluses cause, this inhibition zone, and is followed and is occurred autgmentability oligemia (spreading 0ligemia) to contiguous cortex expansion with the speed of 2～5mm/min.Both are all not according to cerebral arteries distributed expansion, but are undertaken by brain cortex cell architecture model, and expansion does not generally surmount Rolandic fissure forward.CSD can explain migraine aura symptom well.In addition, 5-hydroxy tryptamine (5-HT) participates in headache generation.When headache outbreak starts, 5-HT disengages from platelet, directly acts on the little blood vessel of intracranial and makes it to shrink, and invest in blood vessel wall.When blood plasma 5-HT lowering of concentration, it acts on the effect of large artery trunks tension force contractility and disappears, and headache appears in blood vessel wall expansion.5-HT is a kind of neurotransmitter, is again a kind of circulatory mediator, all influential to nerve and blood vessel.Treating migrainous triptan medicine is exactly central 5-HT receptor stimulating agent or partial agonist.This confirms that nervous dysfunction participates in migrainous episode process.
Nervi trigeminus blood vessel theory: this theory anatomical physiology basis is nervi trigeminus blood vessel complex (trigeminovascular complex).Intracranial Hyperalgesia tissue is as cerebrovascular, meningovascular, venous sinus, and its blood vessel peripheral nerve fiber enters trigeminal ganglion with ophthalmic branch of trigeminal nerve, or enters the rear root of 1,2 cervical nervess (C1, C2) from rear cranium nest; Both change after unit at trigeminal ganglion and C1, C2 spinal ganglion, send nerve fiber to nervi trigeminus neck complex (trigeminocervical complex), and the latter consists of spinal nucleus of trigeminal nerve tail end and C1, C2 relief angle; Nervi trigeminus neck complex sends nerve fiber, after brain stem intersects, is projected to thalamus.Surrounding's Theory of Pain Mechanism of this theory thinks, trigeminal ganglion infringement may be the nerve basis that migraine produces.After trigeminal ganglion and fiber irriate thereof, can cause that Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), calcitonin-gene-related peptide (CGRP) and other neuropeptides discharge increase.These active substances act on Neighbouring Brain blood vessel wall, can cause vasodilation and occur pulsatile headache, also can make vascular permeability increase, and plasma protein extravasation, produces aseptic inflammation, and stimulate pain sensation fiber to import maincenter into, forms vicious cycle.
Trigeminal neuralgia is modal cranial nerve diseases, and the violent pain of the paroxysmal of outbreak repeatedly of take in a side surface part nervi trigeminus areal area is main manifestations, the sickness rate 52.2/10 ten thousand of domestic statistics, and female is slightly more than man, and sickness rate can increase with the age.The multiple middle-aged and elderly people of being born in of trigeminal neuralgia, R)L.This sick feature is: in Head And Face nervi trigeminus distributed areas, morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain in the time of all can causing paroxysmal while even walking.Pain is lasted several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.
Trigeminal neuralgia can be divided into constitutional (symptomatic) trigeminal neuralgia and the large class of secondary trigeminal neuralgia two, and wherein primary trigeminal neuralgia is more common.Primary trigeminal neuralgia refers to have clinical symptoms, but apply various inspections, does not find and the relevant organic disease of falling ill.Secondary trigeminal neuralgia is except there being clinical symptoms, and clinical and imaging examination can find that organic disease is as tumor, inflammation, vascular malformation etc. simultaneously.Secondary trigeminal neuralgia is more common in 40 years old with lower, adolescence, conventionally there is no trigger point, and risk factor is not obvious, and pain is often persistence, and some patients were can be found other performance with primary disease.Brain CT, MRI, nasopharynx part biopsy etc. help diagnosis.
The Chinese patent literature of application publication number CN103349692A (application number 201310192847.X) discloses a kind of Chinese medicine preparation for the treatment of migraine, Trigeminal Neuralgia, chooses Radix Ginseng 60-180g, Radix Angelicae Sinensis 60-180g, Flos Carthami 60-180g, Rhizoma Chuanxiong 80-240g, Radix Aconiti Preparata 80-240g, Radix Saposhnikoviae 80-240g, Radix Angelicae Pubescentis 80-240g, Caulis Sinomenii 90-270g, Fructus Chaenomelis 90-270g, Semen Ziziphi Spinosae 30-120g are prepared from.The Chinese patent literature of publication number CN102357238A (application number 201110328707.1) discloses a kind of prosopalgic Chinese medicine composition for the treatment of, and by the raw material of following weight, is made: Fructus Evodiae 8-10 gram, Radix Ginseng 9-15 gram, Rhizoma Zingiberis Recens 9-15 gram, Fructus Jujubae 9-15 gram, Radix Asparagi 4-8 gram, Radix Ophiopogonis 4-8 gram, Rhizoma Cimicifugae 1-5 gram, Bidens paruiflora Willd. 4-8 gram, Pericarpium Papaveris 4-8 gram, Semen Persicae mud 1-3 gram, Flos Carthami 1-3 gram, Semen Pruni Salicinae 8-10 gram, Rhizoma Gastrodiae 4-6 gram.
In a word, Chinese medicine is being obtained good curative effect in treatment aspect primary disease, but also has some problems: clinically to activating blood circulation to dissipate blood stasis and dredge the collateral, and expelling wind and cold, understand things pain-stopping is desirable not enough, to improving the misery that migraine, trigeminal neuralgia bring, has much room for improvement.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easily the treatment migraine of clothes, prosopalgic Chinese medicine composition and preparation method thereof for a long time.This Chinese medicine composition has activating blood circulation to dissipate blood stasis and dredge the collateral, expelling wind and cold, the effect of understand things pain-stopping.
Technical scheme of the present invention is:
Treat migraine, a prosopalgic Chinese medicine composition, by the crude drug of following weight proportioning, be prepared from: Fructus Viticis 20-40 part, Cornu Saigae Tataricae 3-7 part, Folium Mori 50-150 part, Flos Chrysanthemi 50-150 part, Caulis Polygoni Multiflori 20-40 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Atriplicis Sibiricae 20-40 part, Ramulus Mori 20-40 part, Arisaema Cum Bile 20-40 part, Fructus Pruni persicae immaturus 20-40 part and rice wine 100-200 part.
Foregoing Chinese medicine composition, preferred scheme is, is prepared from: Fructus Viticis 25-35 part, Cornu Saigae Tataricae 4-6 part, Folium Mori 80-120 part, Flos Chrysanthemi 80-120 part, Caulis Polygoni Multiflori 25-35 part, Pericarpium Citri Reticulatae 80-120 part, Fructus Atriplicis Sibiricae 25-35 part, Ramulus Mori 25-35 part, Arisaema Cum Bile 25-35 part, Fructus Pruni persicae immaturus 25-35 part and rice wine 130-180 part by the crude drug of following weight proportioning.
Foregoing Chinese medicine composition, better preferred scheme is, by the crude drug of following weight proportioning, is prepared from: 150 parts, 30 parts of Fructus Viticises, 5 parts of Cornu Saigae Tataricae, 100 parts, Folium Mori, 100 parts of Flos Chrysanthemis, 30 parts of Caulis Polygoni Multiflori, 100 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Atriplicis Sibiricaees, 30 parts of Ramulus Moris, 30 parts of Arisaema Cum Biles, 30 parts of Fructus Pruni persicae immaturuss and rice wine.
According to the preparation method for the treatment of migraine noted earlier, prosopalgic Chinese medicine composition, step is as follows:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 1-5 days, take out stand-by;
(2) step (1) gains are placed on tile and are dried with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 80-120 mesh sieve, Flos Chrysanthemi is put into medicated pillow with together with smalls after sieving;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 60-100 mesh sieve;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume is obtained to concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried to 1-2 hour, obtain oven dry thing, is dry at 70-90 ℃ in temperature;
(7) gained is dried to thing according to the metering of 0.3-0.7g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Foregoing preparation method, preferred scheme is: step (1) is soaked 2-4 days (preferably soaking 3 days) in rice wine.
Foregoing preparation method, preferred scheme is: step (2) is crossed 90-110 mesh sieve (preferably 100 mesh sieves).
Foregoing preparation method, preferred scheme is: step (3) is crossed 70-90 mesh sieve; (preferably 80 mesh sieves).
Foregoing preparation method, preferred scheme is: step (6) is dried 1.3-1.7 hour (preferably 1.5 hours) by thick paste.
Foregoing preparation method, preferred scheme is: step (6) is dry at 75-85 ℃ (preferably 80 ℃ at dry) in temperature.
Foregoing preparation method, preferred scheme is: the dosage form of step (7) gained tablet is 0.4-0.6g/ sheet (preferably 0.5g/ sheet).
Using method: for making the present invention reach optimum therapeuticing effect, take half an hour after breakfast, lunch and dinner, each 3 grams 10 days is a course for the treatment of, is resting the head in bed Chinese medicinal pillow of the present invention.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Viticis: for anemopyretic cold, headache wind syndrome of head.The pungent energy of this product wind that falls apart, the heat clearing away that is slightly cold, frivolous up, the heresy of main loose women's head-ornaments, has the effect of wind-expelling pain-stopping.
Cornu Saigae Tataricae: salty in the mouth; Cold in nature.Suppressing the hyperactive liver to relieve the wind syndrome; Liver heat removing and eyesight improving; Removing pathogenic heat from blood and toxic substance from the body.Clearing away heat and relieving spasm, suppressing the hyperactive liver to relieve the wind syndrome, removing toxic substances and promoting subsidence of swelling.(relieving spasm by subduing liver-wind liver heat removing and eyesight improving heat-clearing and toxic substances removing) cures mainly: for the hot infantile convulsion of height, coma convulsion is fainted, and eclamposia is twitched, and epilepsy is gone mad, have a headache dizzy, and conjunctival congestion cataracta, maculae caused by violent heat pathogen, carbuncle sore tumefacting virus.
Folium Mori: for anemopyretic cold, headache cough.The sweet cold light weight of this product, light clear evacuation, is longer than wind-heat dissipating, again can clearing away lung-heat to relieve cough, thus be usually used in anemopyretic cold or epidemic febrile disease from the beginning of, attack of pathogenic warmth in the lung, heating, headache, the diseases such as cough.
Flos Chrysanthemi: there is loose wind heat clearing away, the effect of suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Caulis Polygoni Multiflori: effect: nourish heart, calm the nerves, dredging collateral, dispels the wind, and cures mainly: control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.
Fructus Atriplicis Sibiricae: bitter, pungent, flat, enter Liver Channel.Suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.For dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.
Ramulus Mori: taste is poor, is slightly cold, nontoxic.Mulberry head: bitter in the mouth, cold in nature, nontoxic.Wind-damp dispelling; The meridian dredging; Row aqueous vapor.Main air pain of dampness syndrome; Apoplexy and hemiplegia; Edema foot gas; Human body pruritus due to wind pathogen.Be used for takeing on arm, joint aches numbness.
Rhizoma Arisaematis: the conventional Rhizoma Zingiberis Recens of Rhizoma Arisaematis or bile are concocted, then use after storage, therefore claim Arisaema Cum Bile.: bitter, micro-pungent, cool.Return lung, liver, spleen channel.Function cures mainly: removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.
Fructus Pruni persicae immaturus: sour, bitter, flat.Return lung, Liver Channel.Arresting sweating arresting seminal emission, promoting blood circulation and hemostasis, pain relieving.For night sweat, seminal emission, cardiac and abdominal pain, spits blood, gestation hemorrhage.
Rice wine: neurasthenia, absentminded, the depressed disease such as forgetful are had to good mitigation, and rice wine can also help blood circulation, enhances metabolism, and has the effect of blood-enriching face-nourishing, relaxing muscles and tendons and activating QI and blood in the collateral, building body and life lengthening.
Chinese medicine composition prescription science provided by the invention, the preparation method of various dosage forms is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected materials is all Chinese medicine material, without any side effects;
2, this prescription meets Chinese medicine principle and migraine, affected nerves of patients with trigeminal neuralgia body and mind feature completely, under the prerequisite of general principle, can have different prescriptions according to different crowd, and function is different.
3, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not limited to this.
Embodiment 1 treatment migraine, prosopalgic Chinese medicine composition, get the raw materials ready (getting 10g for every part) by following weight parts: 100 parts, 20 parts of Fructus Viticises, 3 parts of Cornu Saigae Tataricae, 50 parts, Folium Mori, 50 parts of Flos Chrysanthemis, 20 parts of Caulis Polygoni Multiflori, 50 parts of Pericarpium Citri Reticulataes, 20 parts of Fructus Atriplicis Sibiricaees, 20 parts of Ramulus Moris, 20 parts of Arisaema Cum Biles, 20 parts of Fructus Pruni persicae immaturuss and rice wine.
The preparation method of above-mentioned treatment migraine, prosopalgic Chinese medicine composition:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and are soaked 1 day, take out stand-by;
(2) step (1) gains are placed on tile and are dried with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 80 mesh sieves, Flos Chrysanthemi is put into medicated pillow with together with smalls after sieving, make Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 60 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter:
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume is obtained to concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1 hour, obtain oven dry thing, is dry at 70 ℃ in temperature;
(7) gained is dried to thing according to the metering of 0.3g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Typical case one: Liu XX, man 32 years old, Heze City, Shandong Province personage, cadre at their posts.Patient's readme: had and repeatedly shown effect the right side headache time of 8 years, because operating pressure larger right side headache increases the weight of to have a surplus for 3 years, recently in year, headache is on average shown effect 1-2 time weekly, each lasting about 4 hours, severe headache during outbreak, companion feels sick, vomiting, without speech, limb function and disturbance of consciousness, oral rotundine, Ergotamine heterodyne.Health check-up: blood pressure 130/80mmhg, cranial nerve is normal, and neck is soft, greasy in tongue, rolling pulse.Electroencephalogram is normal, and head CT and magnetic resonance examination are without extremely.Diagnosis: migraine.In this time in 1 year, patient says the doctor who has seen many times, ate a lot of famous and precious medicines, but effect is not fine, in November, 2011, listens friend to say very good of traditional Chinese medicine composition for treating migraine effect of the present invention.Just 4 courses for the treatment of have been bought.
Take the embodiment of the present invention 1 gained Chinese medicine composition and be used in conjunction with embodiment 1 gained Chinese medicinal pillow, after 1 course for the treatment of, patient's sensation pain when morbidity is so inviolent, do not feel sick yet, the symptom such as vomiting, continue to take after 2 courses for the treatment of, basic malaise symptoms disappears, the state of an illness is basicly stable, continues to take to do 1 course for the treatment of and consolidates, nothing recurrence after drug withdrawal.
Embodiment 2 treatment migraine, prosopalgic Chinese medicine composition, get the raw materials ready (getting 20g for every part) by following weight parts: 200 parts, 40 parts of Fructus Viticises, 7 parts of Cornu Saigae Tataricae, 150 parts, Folium Mori, 150 parts of Flos Chrysanthemis, 40 parts of Caulis Polygoni Multiflori, 150 parts of Pericarpium Citri Reticulataes, 40 parts of Fructus Atriplicis Sibiricaees, 40 parts of Ramulus Moris, 40 parts of Arisaema Cum Biles, 40 parts of Fructus Pruni persicae immaturuss and rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and are soaked 5 days, take out stand-by;
(2) step (1) gains are placed on tile and are dried with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 120 mesh sieves, Flos Chrysanthemi is put into medicated pillow with together with smalls after sieving, make Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 100 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume is obtained to concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 2 hours, obtain oven dry thing, is dry at 90 ℃ in temperature;
(7) gained is dried to thing according to the metering of 0.7g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Typical case two: yellow XX, man 28 years old.Henan Zhumadian personage, certain high school teachers.3 years causes be duration headache unbearably, in outpatient service in July, 2010, see a doctor.Patient's readme began to occur the headache of Zuo Temporal side before 3 years, from the beginning of slightly, be bitterly paroxysm and do, and spring, outbreak was more acute, and oral indometacin sheet can be alleviated, and shows effect frequent over 1 year, monthly shows effect 4-5 time, continues 1-2 days at every turn, to make front aethomma dim spot, fuzzy depending on spy; The twinge sense of fighting during outbreak, when heavy companion feel sick, vomiting, be on tenterhooks, local hospital is examined as angioneurotic headache, to wheat clothes peace preparation, first can alleviate, and then gradually loses efficacy.Nearly paroxysmal in March left side headache, head is heavy swollen, pain as being stabbed when heavy, sore spot is fixing not to be moved, and still has the sense of fighting during outbreak, and companion feels sick, vomiting.Clothes medicine-feeding is invalid.Have a medical check-up: sanity, spirit is poor, and cranial nerve is normal, and neck is soft, and myasthenia of limbs, muscular tension are normal, and bilateral pathology is levied feminine gender.Thin white fur of tongue, deep-thready pulse string.Head CT and magnetic resonance examination are normal, are diagnosed as: the migraine being caused by nervi trigeminus.
Give the oral embodiment of the present invention 2 resulting compositions and be used in conjunction with the embodiment of the present invention 2 gained Chinese medicinal pillows, after 3 courses for the treatment of, patient's self-induction attack times obviously reduces, continue to have taken after 3 courses for the treatment of, basic not recurrence, during recurrence, pain degree alleviates, persistent period shortens, continue again to take 1 course for the treatment of, cure completely, 1 year, do not have so far headache outbreak more.
Embodiment 3 treatment migraine, prosopalgic Chinese medicine composition, get the raw materials ready (getting 30g for every part) by following weight parts: 130 parts, 25 parts of Fructus Viticises, 4 parts of Cornu Saigae Tataricae, 80 parts, Folium Mori, 80 parts of Flos Chrysanthemis, 25 parts of Caulis Polygoni Multiflori, 80 parts of Pericarpium Citri Reticulataes, 25 parts of Fructus Atriplicis Sibiricaees, 25 parts of Ramulus Moris, 25 parts of Arisaema Cum Biles, 25 parts of Fructus Pruni persicae immaturuss and rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and are soaked 2 days, take out stand-by;
(2) step (1) gains are placed on tile and are dried with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 90 mesh sieves, Flos Chrysanthemi is put into medicated pillow with together with smalls after sieving, make Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 70 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume is obtained to concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1.3 hours, obtain oven dry thing, is dry at 75 ℃ in temperature;
(7) gained is dried to thing according to the metering of 0.4g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Typical case three: patient: king XX, female, 45 years old, Jiangzhou, Qingdao personage, peasant.Before 1 year, without obvious inducement, there is left side of head pain, every day is pain substantially regularly, the time of general pain can be not oversize, pain is got up just as pinprick, people is on tenterhooks, can not works, sometimes can not the taking food of pain, remove examination in hospital: doctor, according to basic situation, is diagnosed as: trigeminal neuralgia.Owing to being that farmers' family's condition is not flush with money, doctor advised patient takes Chinese medicine composition of the present invention.
Take the embodiment of the present invention 3 gained Chinese medicine compositions and be used in conjunction with embodiment 3 gained Chinese medicinal pillows, after 3 courses for the treatment of, patient's readme, the pain that all regularly showed effect former every day, has remained dormant for 3 days, continues again to take after 1 course for the treatment of, and malaise symptoms disappears substantially.
Embodiment 4 treatment migraine, prosopalgic Chinese medicine composition, get the raw materials ready (getting 40g for every part) by following weight parts: 180 parts, 35 parts of Fructus Viticises, 6 parts of Cornu Saigae Tataricae, 120 parts, Folium Mori, 120 parts of Flos Chrysanthemis, 35 parts of Caulis Polygoni Multiflori, 120 parts of Pericarpium Citri Reticulataes, 35 parts of Fructus Atriplicis Sibiricaees, 35 parts of Ramulus Moris, 35 parts of Arisaema Cum Biles, 35 parts of Fructus Pruni persicae immaturuss and rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and are soaked 4 days, take out stand-by;
(2) step (1) gains are placed on tile and are dried with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 110 mesh sieves, Flos Chrysanthemi is put into medicated pillow with together with smalls after sieving, make Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 90 mesh sieves;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume is obtained to concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried 1.7 hours, obtain oven dry thing, is dry at 85 ℃ in temperature;
(7) gained is dried to thing according to the metering of 0.6g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
Embodiment 5 treatment migraine, prosopalgic Chinese medicine composition, get the raw materials ready (getting 50g for every part) by following weight parts: 150 parts, 30 parts of Fructus Viticises, 5 parts of Cornu Saigae Tataricae, 100 parts, Folium Mori, 100 parts of Flos Chrysanthemis, 30 parts of Caulis Polygoni Multiflori, 100 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Atriplicis Sibiricaees, 30 parts of Ramulus Moris, 30 parts of Arisaema Cum Biles, 30 parts of Fructus Pruni persicae immaturuss and rice wine.
The preparation method for the treatment of migraine, prosopalgic Chinese medicine composition is:
Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and are soaked 3 days, take out to be placed on tile and dries with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, mistake 100 mesh sieves, put into medicated pillow by Flos Chrysanthemi with together with smalls after sieving, make Chinese medicinal pillow; Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are being ground into smalls, are crossing 80 mesh sieves; Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter; Gained filtrate is heated to boiling, continues to filter after 1 hour, concentrating filter liquor to 1/2 of original volume is being obtained to concentrated solution; Gained smalls is poured in the concentrated solution of gained, fully stirred into thick paste; Thick paste being dried 1.5 hours, obtain oven dry thing, is dry at 80 ℃ in temperature; Gained is dried to thing according to the metering of 0.5g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
The clinical practice of test example 1 embodiment 5 gained treatment migraine, prosopalgic Chinese medicine composition: in June, 2008-2012 year December, screens 120 routine patients in 4 hospitals, wherein women's 58 examples, male's 62 examples, oldest 72 years old, minimal ages 18 years old, 50 years old mean age.Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (the conventional medicine such as aspirin, indometacin, Phenylbutazone, acetaminophen).Using method is: tablet is taken half an hour after breakfast, lunch and dinner, and each 3 grams 10 days is a course for the treatment of, is resting the head in bed Chinese medicinal pillow of the present invention.Curative effect situation criterion: cure: take embodiment 5 gained tablets and coordinate a course for the treatment of of embodiment 5 gained Chinese medicinal pillow, malaise symptoms has clear improvement, and pain disappears substantially; Effective: take embodiment 5 gained tablets and coordinate a course for the treatment of of embodiment 5 gained Chinese medicinal pillow, malaise symptoms makes moderate progress, and pain alleviates to some extent; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 18-72 year migraine, affected nerves of patients with trigeminal neuralgia therapeutic outcome
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
The present invention selects Fructus Viticis, Cornu Saigae Tataricae, Folium Mori, Flos Chrysanthemi, Caulis Polygoni Multiflori, Pericarpium Citri Reticulatae, Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile, Fructus Pruni persicae immaturus and rice wine to carry out compatibility, make to produce synergism after these drug regimens, can more effectively treat migraine, trigeminal neuralgia.In side, Folium Mori, Flos Chrysanthemi, Pericarpium Citri Reticulatae and rice wine master are at blood circulation promoting and blood stasis dispelling, hypnotic; Fructus Viticis, Cornu Saigae Tataricae, Caulis Polygoni Multiflori, Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus master be at expelling wind and cold, understand things pain-stopping.All medicines share, and invigorate blood circulation and can yin nourishing, and blood stasis dispelling and just not hindering, has one's ideas straightened out and the QI invigorating of holding concurrently, therefore sensible and pain relieving can obtain good therapeutic effect.Take 10 days, more than 53% feeling takes a turn for the better to some extent, and malaise symptoms improves, and pain alleviates to some extent; Take 20 days, more than 72% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and the mental status is good; Take 30 days, more than 97% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and head CT and magnetic resonance examination show normal, the recovery from illness of some patients were self-induction.In experimental group, take more than 30 days, effective percentage can reach 93%, and matched group is only 76%.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (10)
1. treat migraine, prosopalgic Chinese medicine composition for one kind, it is characterized in that, by the crude drug of following weight proportioning, be prepared from: Fructus Viticis 20-40 part, Cornu Saigae Tataricae 3-7 part, Folium Mori 50-150 part, Flos Chrysanthemi 50-150 part, Caulis Polygoni Multiflori 20-40 part, Pericarpium Citri Reticulatae 50-150 part, Fructus Atriplicis Sibiricae 20-40 part, Ramulus Mori 20-40 part, Arisaema Cum Bile 20-40 part, Fructus Pruni persicae immaturus 20-40 part and rice wine 100-200 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, by the crude drug of following weight proportioning, be prepared from: Fructus Viticis 25-35 part, Cornu Saigae Tataricae 4-6 part, Folium Mori 80-120 part, Flos Chrysanthemi 80-120 part, Caulis Polygoni Multiflori 25-35 part, Pericarpium Citri Reticulatae 80-120 part, Fructus Atriplicis Sibiricae 25-35 part, Ramulus Mori 25-35 part, Arisaema Cum Bile 25-35 part, Fructus Pruni persicae immaturus 25-35 part and rice wine 130-180 part.
3. Chinese medicine composition according to claim 1, it is characterized in that, by the crude drug of following weight proportioning, be prepared from: 150 parts, 30 parts of Fructus Viticises, 5 parts of Cornu Saigae Tataricae, 100 parts, Folium Mori, 100 parts of Flos Chrysanthemis, 30 parts of Caulis Polygoni Multiflori, 100 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Atriplicis Sibiricaees, 30 parts of Ramulus Moris, 30 parts of Arisaema Cum Biles, 30 parts of Fructus Pruni persicae immaturuss and rice wine.
4. according to the preparation method of the arbitrary described treatment migraine of claim 1-3, prosopalgic Chinese medicine composition, it is characterized in that, step is as follows:
(1) Folium Mori, Flos Chrysanthemi and Pericarpium Citri Reticulatae are placed in rice wine and soak 1-5 days, take out stand-by;
(2) step (1) gains are placed on tile and are dried with little fire, the Folium Mori after drying and Pericarpium Citri Reticulatae are ground into the smalls of beans size, cross 80-120 mesh sieve, Flos Chrysanthemi is put into medicated pillow with together with smalls after sieving, make Chinese medicinal pillow;
(3) Fructus Viticis, Cornu Saigae Tataricae and Caulis Polygoni Multiflori are ground into smalls, cross 60-100 mesh sieve;
(4) Fructus Atriplicis Sibiricae, Ramulus Mori, Arisaema Cum Bile and Fructus Pruni persicae immaturus are placed in to intense fire in marmite and are fried open, turn 30 minutes at a simmer, filter;
(5) step (4) gained filtrate is heated to boiling, continues to filter after 1 hour, gained concentrating filter liquor to 1/2 of original volume is obtained to concentrated solution;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stirred into thick paste; Thick paste being dried to 1-2 hour, obtain oven dry thing, is dry at 70-90 ℃ in temperature;
(7) gained is dried to thing according to the metering of 0.3-0.7g/ sheet, according to the preparation for processing of tablet, be pressed into circular or other forms of lamellar dosage form; Gained tablet is taken half an hour after breakfast, lunch and dinner, each 3 grams.
5. preparation method according to claim 4, is characterized in that: step (1) is soaked 2-4 days (preferably soaking 3 days) in rice wine.
6. preparation method according to claim 4, is characterized in that: step (2) is crossed 90-110 mesh sieve (preferably 100 mesh sieves).
7. preparation method according to claim 4, is characterized in that: step (3) is crossed 70-90 mesh sieve; (preferably 80 mesh sieves).
8. preparation method according to claim 4, is characterized in that: step (6) is dried 1.3-1.7 hour (preferably 1.5 hours) by thick paste.
9. preparation method according to claim 4, is characterized in that: step (6) is dry at 75-85 ℃ (preferably 80 ℃ at dry) in temperature.
10. preparation method according to claim 4, is characterized in that: the dosage form of step (7) gained tablet is 0.4-0.6g/ sheet (preferably 0.5g/ sheet).
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| CN104922485A (en) * | 2015-07-04 | 2015-09-23 | 杨永勤 | Traditional Chinese medicine pill for treating migraine and preparing method of traditional Chinese medicine pill |
| CN105381408A (en) * | 2015-12-15 | 2016-03-09 | 刘学来 | Compound preparation for treating trigeminal neuralgia and preparation method thereof |
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| CN1169292A (en) * | 1996-06-21 | 1998-01-07 | 刘庆海 | Preparation of traditional Chinese herbs for treatment of cephalagra |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104922485A (en) * | 2015-07-04 | 2015-09-23 | 杨永勤 | Traditional Chinese medicine pill for treating migraine and preparing method of traditional Chinese medicine pill |
| CN105381408A (en) * | 2015-12-15 | 2016-03-09 | 刘学来 | Compound preparation for treating trigeminal neuralgia and preparation method thereof |
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