CN103584106A - Composition capable of improving bone mineral density - Google Patents
Composition capable of improving bone mineral density Download PDFInfo
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- CN103584106A CN103584106A CN201310626365.0A CN201310626365A CN103584106A CN 103584106 A CN103584106 A CN 103584106A CN 201310626365 A CN201310626365 A CN 201310626365A CN 103584106 A CN103584106 A CN 103584106A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L15/00—Egg products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a composition capable of improving bone mineral density, which relates to a bone mineral density composition. The objective of the invention is to overcome the problems of great toxic and side effects, high cost, etc. of conventional medicines used for increasing bone mineral density. The composition capable of improving bone mineral density comprises, by mass, 40 to 180 parts of hydrolyzed yolk powder, 250 to 1050 parts of eucommia bark, 400 to 1800 parts of kudzu vine root and 150 to 750 parts of fortune's drynaria rhizome. The hydrolyzed yolk powder used in the invention is a functional substance extracted from egg yolk and is cheap, easily available and suitable for industrial production. The three compatible traditional Chinese medicines are materials applicable to health food or both edible and medicinal materials; the traditional Chinese medicines and new resource food are reasonably compounded and exert a synergistic effect, so the effect of improvement of bone mineral density is achieved. The composition has the advantages of simple and practicable preparation, controllable quality and suitability for industrial production. The composition provided by the invention is applicable to the field of health products.
Description
Technical field
The present invention relates to a kind of composition of bone density, belong to health food technology field.
Background technology
Bone density, is an important symbol of bone mass, reflection osteoporosis degree.
Along with the arrival of social senilization, osteoporosis has become one of important health problem of the mankind.Its incidence of disease has leapt to common disease, frequently-occurring disease the 7th.It is that a class follows aging or medical reasons to cause, with bone loss, bone tissue microstructure destroy, bone fragility increases, bone strength declines, risk of fractures frequency increases, take ostalgia, Decrease of Bone Mineral Density, be easy to occur metabolic, the general skeletal diseases that fracture is main clinical characteristics.Its high incidence, high mortality and high disability rate are having a strong impact on the elderly's quality of life, and bring thus huge economy and Community health's burden.
In recent years, relevant Chinese medicine and extract thereof come into one's own day by day to the research of bone mineral density, and research shows that Chinese medicine increases bone density to the elderly and has its unique distinction.Traditional Chinese medicine and modern medicine study are combined, make the health products that increase bone density.Make various composition reasonable formula, coordinate to share, by multipath, reach the health care that increases bone density at many levels.Health products are compared with medicine, have safe, can long-term taking, the people's daily health caring that is content with very little need to wait advantage, is bringing into play more and more important effect in medical market.
Summary of the invention
To the object of the invention is that existing increase bone density poisonous side effect of medicine is large, high in cost of production problem in order solving, and a kind of composition that increases bone substance density improving function that has to be provided.
A kind of composition that increases bone substance density improving function that has of the present invention, is comprised of 150～750 parts of 40～180 parts of yolk powders of hydrolysis, 250～1050 parts of the barks of eucommia, 400～1800 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
The pharmacology of each bulk drug and drug effect in the present invention:
1, hydrolysis yolk powder---
Hydrolysis yolk powder is a kind of functional materials extracting from egg yolk, take egg yolk as raw material, through Protease Treatment, heating, centrifugation, spraying drying and other steps, produces.Hydrolysis on September 9th, 2008 yolk powder is formally approved as new resource food by the Ministry of Public Health, can in normal food, use.(2008 No. 20 bulletin of Ministry of Health of the People's Republic of China).The function of hydrolysis yolk powder is the generation that it can increase Gegenbaur's cell quantity and promote bone; Activate the motive power of bone self, the elongation of promotion bone; Promote the calcareous heavy knot of bone, the toughness of strengthening bone; Suppress the growth of osteoclast, maintain the balance of bone composition.Hydrolysis yolk powder promotes the mechanism of bone growth to be, it,, by stimulating bone sprout cell, promotes the generation of the skeleton growth factor (IGF1, TGF β 1), promotes the growth of bone.By suppressing the secretion (as: IL-1, IL-6, TNF α) of the cell division factor of osteoclast, maintain the balance of bone composition.Promote the absorption of calcium, suppress the excessive loss of calcium simultaneously, thereby promote growth and the health of bone.
2, the bark of eucommia---
Chinese pharmacopoeia is recorded, and the bark of eucommia has filling liver kidney, strengthening the bones and muscles, antiabortive effect.Related documents is recorded, and with general flavone in Bark of Eucommia Ulmoides, adds respectively in the separated Gegenbaur's cell of cultivating of newborn Wistar rat skull the impact with mtt assay evaluation on osteoblastic proliferation with 25ug/ml, 50ug/ml, 100ug/ml concentration.Result shows, eucommiae total flavones can directly promote external osteoblastic propagation.It is osteoblastic effect that eucommiae total flavones has inducing bone mesenchymal Stem cell differentiation, can resist H
2o
2the TNF-a Induced Apoptosis in Osteoblasts of induction, also can promote the propagation of marrow stromal cell, lipoblast to regulate bone metabolism, promotes the formation of bone.Eucommia ulmoides extracts can raise serum E2, IGF1 level, increases bone density, improves the anti-fracture power of castrated rats and bone crushing force level, effectively prevents and delay the generation of the fracture that osteoporosis in castrated rat and osteoporosis cause.
3, the root of kudzu vine---
Plant ， China and some countries and regions that the root of kudzu vine belongs to integration of drinking and medicinal herbs are also food.It has increases bone density, improve primary osteoporosis shape, improve brain blood circulation, hypoglycemic blood fat, the effect such as relieve the effect of alcohol.In recent years, relevant research finds that Kudzu Flavonoids Extracts and Puerarin are improved the effect of bone metabolism, are applicable to prevention of osteoporosis disease.Relevant research shows, the root of kudzu vine improves the metabolic mechanism of bone of osteoporosis model mouse, may by ERs, bring into play the regulating action of bone metabolism relevant with the isoflavones in the root of kudzu vine.In addition, the root of kudzu vine may be independent of the estrogen-like action of isoflavones to the effect of bone metabolism.There are some researches show, the free radical that vivo oxidation reaction produces has the effect that promotes that bone absorbs.In the root of kudzu vine, isoflavones has powerful antioxidation activity.Therefore, the root of kudzu vine may affect bone and absorbs by the antioxidation activity of isoflavones.Use the root of kudzu vine to be better than the reason of its extract or single component, may be as relevant in the calcium of saponin(e, polysaccharide or high-load etc. with other compositions beyond the isoflavones comprising in the root of kudzu vine.
4, the rhizome of davallia---
Chinese pharmacopoeia is recorded, and the rhizome of davallia has the pain relieving of curing the wound, the strong bone of kidney tonifying, the disappear effect of wind nti-freckle of external application.In successive dynasties traumatology monograph, the rhizome of davallia has become orthopaedics key medicine.Song Yuan begins to be used for the treatment of heumatism disease period, is still orthopedics and traumatology common medicine so far.Relevant experiment shows, in to fracture healing in rats experiment, finds that the rhizome of davallia can increase poroma thickness, improves healing of fracture.The rhizome of davallia promotes the mechanism of union may improve the concentration product of blood calcium, phosphorus, promotes calcium, phosphorus deposition, strengthens the interior osteoblastic proliferation of body movable, improves the activity of serum alkaline phosphatase (ALP), promotes union.Relevant research shows, the rhizome of davallia can improve blood calcium serium inorganic phosphorus level, can activate Gegenbaur's cell, improves capital bone density, can prevent glucocorticoid-induced osteoporosis.The part that has the rhizome of davallia suppresses the effect of the bone loss that glucocorticoid causes, the osteoporosis that Dichlorodiphenyl Acetate cortisone causes under test dose has inhibitory action.
The present invention comprises following beneficial effect:
The present invention will improve the bark of eucommia, the root of kudzu vine, the rhizome of davallia and the combination of new resources hydrolysis yolk powder of bone density successful, clinical prolonged application in Chinese traditional herbs, these active components improve bone density, promote calcium absorption approach according to abundant, each active component cooperative compensating, plays the effect that increases bone density altogether.And in three taste Chinese medicines, the rhizome of davallia, the bark of eucommia belong to the article that can be used for health food, the root of kudzu vine belongs to and is the article of food and medicine, safe and reliable, quality controllable, and effective, meets State Food and Drug Administration's healthy food material and uses regulation.Hydrolysis yolk powder, is a kind of functional materials extracting from egg yolk, cheap and easy to get, is the new resources that are worth being widely used, and is easy to suitability for industrialized production.
Said composition is by new resources and traditional Chinese medicine reasonable formula, play its effect altogether, and its effect that increases bone density is better than simple new resources or Chinese prescription.Simple, quality controllable, the applicable suitability for industrialized production of preparation method provided by the present invention.
The specific embodiment
The specific embodiment one: present embodiment a kind of has the composition that increases bone substance density improving function, is comprised of 150～750 parts of 40～180 parts of yolk powders of hydrolysis, 250～1050 parts of the barks of eucommia, 400～1800 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
The pharmacology of each bulk drug and drug effect in present embodiment:
1, hydrolysis yolk powder---
Hydrolysis yolk powder is a kind of functional materials extracting from egg yolk, take egg yolk as raw material, through Protease Treatment, heating, centrifugation, spraying drying and other steps, produces.Hydrolysis on September 9th, 2008 yolk powder is formally approved as new resource food by the Ministry of Public Health, can in normal food, use.(2008 No. 20 bulletin of Ministry of Health of the People's Republic of China).The function of hydrolysis yolk powder is the generation that it can increase Gegenbaur's cell quantity and promote bone; Activate the motive power of bone self, the elongation of promotion bone; Promote the calcareous heavy knot of bone, the toughness of strengthening bone; Suppress the growth of osteoclast, maintain the balance of bone composition.Hydrolysis yolk powder promotes the mechanism of bone growth to be, it,, by stimulating bone sprout cell, promotes the generation of the skeleton growth factor (IGF1, TGF β 1), promotes the growth of bone.By suppressing the secretion (as: IL-1, IL-6, TNF α) of the cell division factor of osteoclast, maintain the balance of bone composition.Promote the absorption of calcium, suppress the excessive loss of calcium simultaneously, thereby promote growth and the health of bone.
2, the bark of eucommia---
Chinese pharmacopoeia is recorded, and the bark of eucommia has filling liver kidney, strengthening the bones and muscles, antiabortive effect.Related documents is recorded, and with general flavone in Bark of Eucommia Ulmoides, adds respectively in the separated Gegenbaur's cell of cultivating of newborn Wistar rat skull the impact with mtt assay evaluation on osteoblastic proliferation with 25ug/ml, 50ug/ml, 100ug/ml concentration.Result shows, eucommiae total flavones can directly promote external osteoblastic propagation.It is osteoblastic effect that eucommiae total flavones has inducing bone mesenchymal Stem cell differentiation, can resist H
2o
2the TNF-a Induced Apoptosis in Osteoblasts of induction, also can promote the propagation of marrow stromal cell, lipoblast to regulate bone metabolism, promotes the formation of bone.Eucommia ulmoides extracts can raise serum E2, IGF1 level, increases bone density, improves the anti-fracture power of castrated rats and bone crushing force level, effectively prevents and delay the generation of the fracture that osteoporosis in castrated rat and osteoporosis cause.
3, the root of kudzu vine---
Plant ， China and some countries and regions that the root of kudzu vine belongs to integration of drinking and medicinal herbs are also food.It has increases bone density, improve primary osteoporosis shape, improve brain blood circulation, hypoglycemic blood fat, the effect such as relieve the effect of alcohol.In recent years, relevant research finds that Kudzu Flavonoids Extracts and Puerarin are improved the effect of bone metabolism, are applicable to prevention of osteoporosis disease.Relevant research shows, the root of kudzu vine improves the metabolic mechanism of bone of osteoporosis model mouse, may by ERs, bring into play the regulating action of bone metabolism relevant with the isoflavones in the root of kudzu vine.In addition, the root of kudzu vine may be independent of the estrogen-like action of isoflavones to the effect of bone metabolism.There are some researches show, the free radical that vivo oxidation reaction produces has the effect that promotes that bone absorbs.In the root of kudzu vine, isoflavones has powerful antioxidation activity.Therefore, the root of kudzu vine may affect bone and absorbs by the antioxidation activity of isoflavones.Use the root of kudzu vine to be better than the reason of its extract or single component, may be as relevant in the calcium of saponin(e, polysaccharide or high-load etc. with other compositions beyond the isoflavones comprising in the root of kudzu vine.
4, the rhizome of davallia---
Chinese pharmacopoeia is recorded, and the rhizome of davallia has the pain relieving of curing the wound, the strong bone of kidney tonifying, the disappear effect of wind nti-freckle of external application.In successive dynasties traumatology monograph, the rhizome of davallia has become orthopaedics key medicine.Song Yuan begins to be used for the treatment of heumatism disease period, is still orthopedics and traumatology common medicine so far.Relevant experiment shows, in to fracture healing in rats experiment, finds that the rhizome of davallia can increase poroma thickness, improves healing of fracture.The rhizome of davallia promotes the mechanism of union may improve the concentration product of blood calcium, phosphorus, promotes calcium, phosphorus deposition, strengthens the interior osteoblastic proliferation of body movable, improves the activity of serum alkaline phosphatase (ALP), promotes union.Relevant research shows, the rhizome of davallia can improve blood calcium serium inorganic phosphorus level, can activate Gegenbaur's cell, improves capital bone density, can prevent glucocorticoid-induced osteoporosis.The part that has the rhizome of davallia suppresses the effect of the bone loss that glucocorticoid causes, the osteoporosis that Dichlorodiphenyl Acetate cortisone causes under test dose has inhibitory action.
Present embodiment will be improved the bark of eucommia, the root of kudzu vine, the rhizome of davallia and the combination of new resources hydrolysis yolk powder of bone density successful, clinical prolonged application in Chinese traditional herbs, these active components improve bone density, promote calcium absorption approach according to abundant, each active component cooperative compensating, plays the effect that increases bone density altogether.And in three taste Chinese medicines, the rhizome of davallia, the bark of eucommia belong to the article that can be used for health food, the root of kudzu vine belongs to and is the article of food and medicine, safe and reliable, quality controllable, and effective, meets State Food and Drug Administration's healthy food material and uses regulation.Hydrolysis yolk powder, is a kind of functional materials extracting from egg yolk, cheap and easy to get, is the new resources that are worth being widely used, and is easy to suitability for industrialized production.
Hydrolysis yolk powder in present embodiment is bought from Nantong Kant's biological products Co., Ltd.
The specific embodiment two: present embodiment is different from the specific embodiment one: described have increase the composition of bone substance density improving function and formed by 150～700 parts of 50～170 parts of yolk powders of hydrolysis, 300～1000 parts of the barks of eucommia, 500～1700 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with the specific embodiment one.
The specific embodiment three: present embodiment is different from the specific embodiment one or two: described have increase the composition of bone substance density improving function and formed by 200～600 parts of 60～160 parts of yolk powders of hydrolysis, 400～900 parts of the barks of eucommia, 600～1600 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with the specific embodiment one or two.
The specific embodiment four: present embodiment is different from one of specific embodiment one to three: described have increase the composition of bone substance density improving function and formed by 200～550 parts of 70～150 parts of yolk powders of hydrolysis, 400～800 parts of the barks of eucommia, 700～1500 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to three.
The specific embodiment five: present embodiment is different from one of specific embodiment one to four: described have increase the composition of bone substance density improving function and formed by 250～500 parts of 80～140 parts of yolk powders of hydrolysis, 400～750 parts of the barks of eucommia, 700～1400 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to four.
The specific embodiment six: present embodiment is different from one of specific embodiment one to five: described have increase the composition of bone substance density improving function and formed by 300～500 parts of 90～130 parts of yolk powders of hydrolysis, 450～700 parts of the barks of eucommia, 800～1200 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to five.
The specific embodiment seven: present embodiment is different from one of specific embodiment one to six: described have increase the composition of bone substance density improving function and formed by 350～500 parts of 90～120 parts of yolk powders of hydrolysis, 500～650 parts of the barks of eucommia, 900～1100 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to six.
The specific embodiment eight: present embodiment is different from one of specific embodiment one to seven: described have increase the composition of bone substance density improving function and formed by 350～450 parts of 90～110 parts of yolk powders of hydrolysis, 550～650 parts of the barks of eucommia, 900～1050 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to seven.
The specific embodiment nine: present embodiment is different from one of specific embodiment one to eight: described have increase the composition of bone substance density improving function and formed by 400～450 parts of 95～105 parts of yolk powders of hydrolysis, 550～600 parts of the barks of eucommia, 900～1000 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to eight.
The specific embodiment ten: present embodiment is different from one of specific embodiment one to nine: described have increase the composition of bone substance density improving function and formed by 400 parts of 100 parts of yolk powders of hydrolysis, 600 parts of the barks of eucommia, 1000 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.Other is identical with one of specific embodiment one to nine.
The specific embodiment 11: the preparation method of composition with increase bone substance density improving function of present embodiment is as follows: get 600 parts of barks of eucommia, 1000 parts of roots of kudzu vine, 400 parts of rhizomes of davallia, add 8～12 times of amount deionized waters to decoct 2 times, each 1.5 hours, obtain water extract; Then in water extract, add 100 parts of hydrolysis yolk powders fully to dissolve, then add proper honey, make oral liquid.
Press practice of pharmacy, can also will in present embodiment, there is a kind of in the middle of the agent of composition granulation, tablet, capsule, pill, dripping pill and the supensoid agent that increases bone substance density improving function.Present embodiment has in the various formulations of the composition that increases bone substance density improving function, also can add conventional drug excipient, as solvent, disintegrant, flavouring, anticorrisive agent, colouring agent etc.
By following evidence the present invention, there is increase bone substance density improving function:
One, zoopery
1, experiment purpose
Study the effect that increases the composition of bone substance density improving function increase bone density that has of the present invention
2, Experimental agents
The composition (tablet) with increase bone substance density improving function preparing by the specific embodiment 11.
3, animal used as test
SPF level rat, female, Heilongjiang University of Chinese Medicine's Experimental Animal Center provides.
4, experimental technique and result
Choosing 140 of healthy SD rats, is female entirely, and first body weight 200 ± 20g carries out modeling processing.Rat is through the anesthesia of lumbar injection 50mg/kg yellow Jackets, and after abdomen position is fixing, in ventrimeson apart from introitus 3～4cm place unhairing, sterilization, by the silk thread ligation of fallopian tubal under ovary, wipes out ovary, with method, wipes out another side ovary.Rat is divided into groups at random, the Chinese drug-treated group that having of being respectively that Normal group, model control group, the specific embodiment 11 make increases the composition group of bone substance density improving function (low, in and high dose group), hydrolysis yolk powder group and be comprised of according to 6:10:4 the bark of eucommia, the root of kudzu vine, the rhizome of davallia; Every group of 18～20 mouse.Respectively each group rat is weighed, numbering, and carry out administration by the dosage in table 1.
According to the changes of weight of rat, adjust dosage weekly.
After 6 months, measure BMD value, femur weight in wet base, wet density, the dry density of the bone density of respectively organizing rat, measurement result is as shown in table 1:
Table 1 has increases the affect result of the composition of bone substance density improving function on ovariectomized female rats bone density BMD
Note: with model control group comparison same period * P<0.05; * P<0.01; * * P<0.001.
From table 1 experimental result, the bone density of the neck of femur of model control group rat and femur distal end is starkly lower than Normal group, has significant difference (P<0.001), shows osteoporosis model modeling success.The middle and high dosage group with the composition that increases bone substance density improving function that the specific embodiment 11 makes all can increase the BMD value of neck of femur and the femur distal end of ovariectomized female rats significantly, wherein the specific embodiment 11 makes have the composition that increases bone substance density improving function middle and high dosage group femoral neck BMD value with the same period model control group compare, there is significant difference (P<0.01).The middle and high dosage group of neck of femur has improved 14.96%, 14.46% than the bone density of model group respectively; The middle and high dosage group of femur meta has improved 4.63%, 8.59% than the bone density of model group respectively; The middle and high dosage group of femur distal end has improved 11.02%, 9.4% than the bone density of model group respectively.The composition group with increase bone substance density improving function that the specific embodiment 11 makes, the effect that hydrolysis yolk powder and three taste Chinese prescriptions increase bone density is better than using and being hydrolyzed yolk powder or using merely Chinese prescription merely.
In sum: the middle and high dosage group with the composition that increases bone substance density improving function that the specific embodiment 11 makes has good effect to the bone density increase of ovariectomized female rats.
Table 2 has increases the affect result of the composition of bone substance density improving function on ovariectomized in rats wet density, dry density
Note: with model control group comparison same period * P<0.05; * P<0.01; * * P<0.001.
From table 2 experimental result, the femur wet density of model control group rat and dry density value all obviously reduce, with the same period Normal group compare, there is significant difference (P<0.05, P<0.001); The middle and high dosage group with the composition that increases bone substance density improving function that the specific embodiment 11 makes can increase femur wet density and the dry density of ovariectomized female rats, wherein the specific embodiment 11 makes have the composition that increases bone substance density improving function high dose group femoral shaft density value with the same period model control group compare, there is significant difference (P<0.001, P<0.01); In sum, the dosage in the composition that increases bone substance density improving function that has that the specific embodiment 11 makes has good effect to the bone density increase of ovariectomized female rats.The composition with increase bone substance density improving function that the specific embodiment 11 makes, the effect that hydrolysis yolk powder and three taste Chinese prescriptions increase bone density is better than using and being hydrolyzed yolk powder or using merely Chinese prescription merely.
Two, clinical testing
What the specific embodiment 11 was made has a composition (tablet) that increases bone substance density improving function, chooses to suffer from osteoporotic patient and verify, usage and dosage is: oral, 0.8 gram/piece, each 2, take 30 days cycles, one day twice, result was as shown in table 3.
Table 3 has increases the composition of bone substance density improving function to osteoporosis symptom patient clinical test data
As can be seen from Table 3, there is bad reaction in none example of 15 routine sufferers of osteoporosis face, and after 30 days, symptom all alleviates.It is good to the result for the treatment of of osteoporosis symptom that having of illustrating that the specific embodiment 11 makes increases the composition of bone substance density improving function, and curing total effective rate is 98%.
Claims (10)
1. there is a composition that increases bone substance density improving function, it is characterized in that having and increase the composition of bone substance density improving function and formed by 150～750 parts of 40～180 parts of yolk powders of hydrolysis, 250～1050 parts of the barks of eucommia, 400～1800 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
2. a kind of composition that improves memory function that has according to claim 1, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 150～700 parts of 50～170 parts of yolk powders of hydrolysis, 300～1000 parts of the barks of eucommia, 500～1700 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
3. a kind of composition that improves memory function that has according to claim 2, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 200～600 parts of 60～160 parts of yolk powders of hydrolysis, 400～900 parts of the barks of eucommia, 600～1600 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
4. a kind of composition that improves memory function that has according to claim 3, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 200～550 parts of 70～150 parts of yolk powders of hydrolysis, 400～800 parts of the barks of eucommia, 700～1500 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
5. a kind of composition that improves memory function that has according to claim 4, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 250～500 parts of 80～140 parts of yolk powders of hydrolysis, 400～750 parts of the barks of eucommia, 700～1400 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
6. a kind of composition that improves memory function that has according to claim 5, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 300～500 parts of 90～130 parts of yolk powders of hydrolysis, 450～700 parts of the barks of eucommia, 800～1200 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
7. a kind of composition that improves memory function that has according to claim 6, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 350～500 parts of 90～120 parts of yolk powders of hydrolysis, 500～650 parts of the barks of eucommia, 900～1100 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
8. a kind of composition that improves memory function that has according to claim 7, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 350～450 parts of 90～110 parts of yolk powders of hydrolysis, 550～650 parts of the barks of eucommia, 900～1050 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
9. a kind of composition that improves memory function that has according to claim 8, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 400～450 parts of 95～105 parts of yolk powders of hydrolysis, 550～600 parts of the barks of eucommia, 900～1000 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
10. a kind of composition that improves memory function that has according to claim 9, is characterized in that described having increases the composition of bone substance density improving function and be comprised of 400 parts of 100 parts of yolk powders of hydrolysis, 600 parts of the barks of eucommia, 1000 parts of the roots of kudzu vine and the rhizomes of davallia by mass fraction.
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| CN112352894A (en) * | 2020-11-02 | 2021-02-12 | 山东贝隆杜仲生物工程有限公司 | Nutritious food prepared from Eucommiae cortex for improving bone density of astronaut, and its application |
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Application publication date: 20140219 |