CN105520135A - Healthy food with function of treating osteoporosis - Google Patents

Healthy food with function of treating osteoporosis Download PDF

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CN105520135A
CN105520135A CN 201510954489 CN201510954489A CN105520135A CN 105520135 A CN105520135 A CN 105520135A CN 201510954489 CN201510954489 CN 201510954489 CN 201510954489 A CN201510954489 A CN 201510954489A CN 105520135 A CN105520135 A CN 105520135A
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calcium
healthy food
polypeptide
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CN 201510954489
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雷西云
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雷西云
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention provides a healthy food, and belongs to the technical field of healthy foods. The healthy food is characterized by being prepared from the following raw materials in parts by weight: 2 parts of vitamin K2, 12 parts of curcumin, 10 parts of calcium carbonate, 5 parts of casein phosphopeptide, 3 parts of magnesium lactate, 5 parts of whole milk powder, 5 parts of epimedium, 1 part of polypeptide, 1 part of carboxymethyl cellulose and 1 part of magnesium stearate. The healthy food has the capability of improving calcium absorption, and has a great advantage to improvement of body bones.

Description

一种具有治疗骨质疏松功能的保健食品 A kind of health food function of the treatment of osteoporosis

技术领域 FIELD

[0001]本发明属于保健食品技术领域,具体涉及一种具有保健功能的保健食品。 [0001] The present invention belongs to the technical field of health food, particularly relates to a health food having a health-care function.

背景技术 Background technique

[0002] 中国老龄化人口数目众多,随着老龄化人口增加,老龄人出现的骨质疏松症较多, 而每年由于骨质疏松导致的骨折病人较多。 [0002] the large number of China's aging population, increase as the population ages, older people appear more osteoporosis, and fracture patients every year due to osteoporosis caused more. 给老龄人的生活带来了较多的不便。 Aging people's lives to a greater amount of inconvenience. 钙是构成骨骼最重要的物质,人体从膳食和营养品中吸收的钙,经过成骨细胞的作用,沉积在骨骼上,以保证骨骼强壮有力。 Calcium is the most important material from which bones, absorbed from the diet and calcium supplements, through the action of osteoblasts, the bone is deposited, in order to ensure sturdy bone. 但是,骨骼并非一旦形成,就再也不会改变了。 However, bone is not once formed, it will never change. 随着年龄的增加, 人体的消化吸收水平下降,激素水平出现变化,骨骼中的钙会慢慢地流失,导致骨骼变得松软、脆弱,椎体变形、体态变形致"龟背"出现,伴有周身骨骼的疼痛等症状,称为骨质疏松症,是一种全身性的骨骼疾病。 With increasing age, the body's digestion and absorption levels drop, hormone changes in levels of calcium in the bones will slowly drain, causing bones to become soft, fragile vertebrae deformation, deformation of the body caused by "Turtle" appears, with there are whole body bone pain and other symptoms, known as osteoporosis, it is a systemic skeletal disease. 骨质疏松在临床上表现为腰背疼、病理性骨折。 Osteoporosis in clinical performance as back pain, pathological fractures. 钙的缺乏和流失在人到中年以后是会普遍发生的。 Lack of calcium and loss after middle age will generally occur. 中老年人由于基础代谢下降,合成代谢降低,分解代谢增高,合成与分解代谢失去平衡,引起细胞功能下降。 Since the basal metabolic decline in the elderly, anabolic reduced, increased catabolism, synthesis and catabolism out of balance, causing cell function decline. 体内脂肪组织往往随着年龄的增加而增加,而脂肪以外的组织则随着年龄的增加而减少,具体表现在:①细胞数量下降体内水分减少;③骨组织矿物质减少,骨组织量减少;④血管逐渐硬化;⑤肝肾功能和脑细胞代谢等也随着年龄的增加而有不同程度的下降内分泌系统功能改变以及吸收代谢功能的减弱, 导致骨质疏松的发病率增高,骨密度明显低于青年人。 Fat tissue tends to increase with increasing age, and tissue other than fat is reduced with increasing age, specifically includes: ① to reduce the in vivo decrease in cell number of water; ③ reduced bone mineral, reducing the amount of bone tissue; ④ gradual hardening of blood vessels; ⑤ brain cell metabolism and liver and kidney function, also with increasing age has decreased function of the endocrine system as well as various degrees of reduced absorption and metabolism function, resulting in increased incidence of osteoporosis, bone density is significantly lower to young people. 有文献报道,正常人在成年后骨组织量仍可增加,在30-35岁间骨密度达到峰值,随后逐渐下降,至70岁时可降低20-30%,因此老年人易发骨质疏松症和骨折。 It has been reported, the amount of normal bone tissue can still be increased in adulthood, bone mineral density between 30-35 years old reached a peak, then decreased gradually, until the age of 70 can be reduced by 20-30%, so the elderly prone to osteoporosis disease and fractures. 老年人由于关节滑液减少,软组织不断退化和磨损,出现关节退行性改变、关节疼痛、关节肿胀等一系列病症,严重影响中老年人的健康。 The elderly due to the decrease of synovial fluid, soft tissue degeneration and continue to wear, degenerative joint changes, joint pain, joint swelling and a series of symptoms appear, seriously affect the health of the elderly.

[0003] 目前防止骨质疏松的保健品较多,大多是单纯的补钙,但是现有的保健品,钙吸收率较低,并不能防止骨质流失。 [0003] Currently prevent osteoporosis more health care products, mostly pure calcium, but the existing health care products, low calcium absorption rate, it does not prevent bone loss.

[0004] 因此,很有必要在现有技术的基础之上,研发设计一种组份配比科学合理,不仅能补钙,特别是能防止骨质流失的保健品。 [0004] Therefore, it is necessary on the basis of prior art, part science research and development to design a set of reasonable proportion, not only calcium, especially to prevent bone loss and health products.

发明内容 SUMMARY

[0005] 本发明的目的是一种具有预防骨质疏松作用的保健食品,通过相关营养物的有机结合,使本品具有把多种不同功效成分融入产品中,这些成分相互配合,协同作用,全面补充骨骼营养,促进钙质吸收,促进胶原生成,防止骨骼中的钙流失,预防骨质疏松的发生,以保证骨骼强壮有力。 [0005] It is an object of the present invention having a health food for preventing osteoporosis action by binding organic nutrients associated, so that the product having the plurality of different functional components into products, these ingredients with each other, a synergistic effect, full complement of bone nutrition, to promote calcium absorption, promote collagen production and prevent the loss of calcium in the bones, preventing osteoporosis, the bone in order to ensure sturdy.

[0006] 本发明的技术方案:一种具有预防骨质疏松作用的保健食品,其特征在于,按重量比:维生素K2 2-8份,姜黄素3 -12份,碳酸钙10-15份,酪蛋白磷酸肽4-5份,乳酸镁3-5份,全脂奶粉2-5份,淫羊藿5份,多肽1-3份,羧甲基纤维素1份,硬脂酸镁1份。 [0006] aspect of the present invention: health food having an action of prevention of osteoporosis, characterized in that the ratio by weight: parts of vitamin K2 2-8, 3-12 parts by curcumin, 10-15 parts of calcium carbonate, casein phosphopeptide 4-5 parts, 3-5 parts of magnesium lactate, 2-5 parts of whole milk powder, 5 parts of epimedium, 1-3 parts polypeptide, carboxymethyl cellulose, 1 part magnesium stearate 1 part .

[0007] 为保证产品质量,所有操作均应在洁净的干燥环境内进行。 [0007] In order to ensure product quality, all operations should be carried out in a clean, dry environment.

[0008] 其中酪蛋白磷酸肽是从牛乳酪蛋白通过生物技术制得的一种含有磷酸基的多肽,具有促进人体吸收钙的生理活性,能促进钙的吸收和利用。 [0008] wherein the casein phosphopeptide is a casein from bovine polypeptide by containing a phosphoric acid group obtained by biotechnology, the body having a physiological activity to promote the absorption of calcium, can promote the absorption and utilization of calcium.

[0009] 本发明的技术优点: 本发明研制了具有预防骨质疏松作用的保健食品,通过以上营养物的有机结合,使本品具有把多种不同功效成分融入产品中,这些成分相互配合,协同作用,全面补充骨骼营养,促进钙质吸收,促进胶原生成,防止骨骼中的钙流失,预防骨质疏松的发生,以保证骨骼强壮有力。 [0009] Technical advantages of the present invention: The present invention has been developed with the health food for preventing osteoporosis effects, by combining the above organic nutrients, so that the product having the plurality of different functional components into products, these ingredients with each other, synergy, full complement bone nutrition, to promote calcium absorption, promote collagen production and prevent the loss of calcium in the bones, prevent the occurrence of osteoporosis, the bone in order to ensure sturdy.

[0010] 所以,本发明的具有预防骨质疏松作用的保健食品在调整人体机能、为骨骼提供营养、补充钙质、防止钙流失等方面的特点。 [0010] Therefore, health food with the prevention of osteoporosis according to the invention in the adjustment function of the body, nourish the bones, calcium supplements to prevent calcium loss and other aspects of the characteristics.

具体实施方式 detailed description

[0011] 实施例1多肽的获得将蝉蛹用水洗净匀浆后溶于丙酮中脱脂,离心所得残渣用水配成悬浊液,将悬浊液在90° C加热10分钟,冷却后调pH值至8,加木瓜蛋白酶和胰蛋白酶水解,水解时间为2.5h,温度为55° C,pH值为6. 5,酶用量为1%,离心或过滤所得上清液为多肽溶液,将所述的多肽溶液用葡聚糖G_50(Sephadex G-50) (1 · 5cmX 90cm)分离,20mmol/L HCl溶液洗脱,流速1 · 3mL/ 分钟,收集洗脱产物,调节溶液至pH7.0,10000转/分钟离心15分钟,上清液冷冻干燥备用; 经十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE),回收小分子量的条带,共得到38个小肽的序列。 [0011] The polypeptide obtained in Example 1 was washed with water after cicada pupa degreased homogenate was dissolved in acetone, the resulting residue was washed with water by centrifugation formulated as suspension, the suspension was heated at 90 ° C 10 minutes, cooled pH adjusted value to 8, plus papain and trypsin hydrolysis, time of 2.5h, a temperature of 55 ° C, pH value of 6.5, an enzyme dosage of 1%, the resulting supernatant by centrifugation or filtration of polypeptide solution, the said polypeptide solution of dextran G_50 (Sephadex G-50) (1 · 5cmX 90cm) separation, 20mmol / L HCl solution was eluted, the flow rate of 1 · 3mL / min, product eluted was collected, the solution was adjusted to pH 7.0, centrifuged at 10,000 rpm / min for 15 minutes and the supernatant was freeze-dried for later use; sodium dodecyl sulfate - polyacrylamide gel electrophoresis (SDS-PAGE), bands recovered low molecular weight, small peptide sequences were obtained 38 . 经过验证,其中有16个小肽具有促进钙质吸收的功能。 Verified, 16 small peptides which promote calcium absorption function. 根据色谱柱中不同的峰值分离时间,可以批量获得相应的小肽。 The peak separation column different time, to obtain the corresponding batch can be small peptides.

[0012] CY-I-7:NQRYDYPCHVPVMQSVPYK; CY-2-3: VGQSRVMALMTQFMSCRQ; CY-1-9:WKSDQTDINSGGACGYQ; CY-2-9:SKSVHDQEPYLffffNNP; CY-2-13:PECHLSRFRFFPSQ ; CY-3-1:HPQPEGWKFAPWMHPAHQN; CY-3-5:PLIINLSffRVSVffFHHSV; CY-3-7:GRHCEQLRGAVEffASGS; CY-3-ll:SQPSSVGHHISLICRH; CY-4-1:TVESQNPACVFPffE; CY-4-3:SIffAEPffRFQHPNPNRffTff; CY-4-5:NRSAffLISPHHGSQffTffR; CY-4-7:ASffLGYARQRGffSGDAM; CY-4-9:CffGRNCHPQTKCKIIV; CY-4-I3:YHKQDPRKCYCRSff ; CY-4-15:CNHCRHSHQffFffD. 实施例2食品的制备1 取维生素K2 2份,姜黄素12份,碳酸钙10份,酪蛋白磷酸肽5份,乳酸镁3份,全脂奶粉5份,淫羊藿5份,多肽1份(取16种小肽的一种),羧甲基纤维素1份,硬脂酸镁1份,混合均匀,磨成细粉,过120目筛,然后灭菌、分装,得本发明保健食品(16种小肽制备成为16种相应的食品)。 [0012] CY-I-7: NQRYDYPCHVPVMQSVPYK; CY-2-3: VGQSRVMALMTQFMSCRQ; CY-1-9: WKSDQTDINSGGACGYQ; CY-2-9: SKSVHDQEPYLffffNNP; CY-2-13: PECHLSRFRFFPSQ; CY-3-1: HPQPEGWKFAPWMHPAHQN ; CY-3-5: PLIINLSffRVSVffFHHSV; CY-3-7: GRHCEQLRGAVEffASGS; CY-3-ll: SQPSSVGHHISLICRH; CY-4-1: TVESQNPACVFPffE; CY-4-3: SIffAEPffRFQHPNPNRffTff; CY-4-5: NRSAffLISPHHGSQffTffR; CY -4-7: ASffLGYARQRGffSGDAM; CY-4-9: CffGRNCHPQTKCKIIV; CY-4-I3: YHKQDPRKCYCRSff; CY-4-15: CNHCRHSHQffFffD 1 take 2 parts of vitamin K2 Example 2 preparation food embodiment, curcumin 12 parts carbonate. 10 parts of calcium casein phosphopeptide 5 parts, 3 parts of magnesium lactate, 5 parts of whole milk powder, 5 parts of epimedium, a part of the polypeptide (taking one of the 16 small peptides), 1 part of carboxymethyl cellulose, 1 part of magnesium stearate, mixed, finely pulverized through a 120 mesh sieve, and then sterilizing, packaging, to obtain health food of the present invention (prepared as 16 kinds of small peptides corresponding to 16 kinds of food).

[0013] 实施例3食品的制备方法2 取维生素K2 8份,姜黄素3份,碳酸钙15份,酪蛋白磷酸肽4份,乳酸镁5份,全脂奶粉2份,淫羊藿5份,多肽3份(16种小肽的一种),羧甲基纤维素1份,硬脂酸镁1份混合均匀,磨成细粉,过120目筛,然后灭菌、分装,得本发明保健食品(16种小肽制备成为16种相应的食品)。 Example 3 Preparation of food [0013] Embodiment 2 taken vitamin K2 8 parts, curcumin 3 parts, 15 parts of calcium carbonate, 4 parts of casein phosphopeptides, 5 parts of magnesium lactate, 2 parts of whole milk powder, 5 parts of Epimedium , polypeptide 3 parts (one of the 16 small peptides), 1 part of carboxymethyl cellulose, 1 part of magnesium stearate was mixed, ground into a fine powder, through a 120 mesh sieve, and then sterilizing, packaging, to give the present health food invention (prepared as 16 kinds of 16 kinds of small peptides corresponding food).

[0014] 实施例4安全性检测将实施例2和3制备得到的食品进行安全性验证,根据本领域常规的验证方法,可以得出本发明经动物试验证实安全无毒,实验结果与结论如下: (1) 急性毒性实验表明:根据急性毒性剂量分级标准,属实际无毒性级; (2) 骨髓细胞微核试验、精子畸形试验、Ames试验结果为阴性; (3) 30天喂养试验:实验动物生长情况良好,血液学检查,生化学检查,主要脏体比及组织学检查结果与对照组相比,均未见异常,证明本发明安全无毒。 Food Examples 2 and 3 prepared in [0014] Example 4 embodiment will be detected security authentication security, authentication according to conventional methods in the art, the present invention can be obtained by the animal experiments proved safe and nontoxic, the following results and conclusions : (1) acute toxicity test showed that: The acute toxic dose classification standard, is actually non-toxic level; (2) bone marrow cell micronucleus test, sperm abnormality test, Ames test result is negative; (3) 30 day feeding experiment: experimental the growth of good, hematologic, biochemical tests, and the ratio of the main body dirty histology compared with control, were normal, non-toxic and demonstrate the safety of the present invention.

[0015] 实施例5促进钙吸收的实验验证将实施例2和3制备得到的32种食品,分别喂食实验小白鼠。 [0015] Example 5 promote calcium absorption experiments in Example 2 and 3 prepared 32 kinds of food, the experimental mice were fed. 按照国家2005版药典的安全毒性实验方法进行。 Experiments carried out in accordance with the methods of the Security toxicity National Pharmacopoeia 2005 edition. 小鼠体重为18-20克,雌雄各半,每组4只。 Mice weighing 18-20 g, male and female, four per group. 试验分17组。 17 minutes the test group. 第1组为正常对照组,饲喂常规饲料。 The first group was the control group fed with normal diet. 第2-17组为实施例2加钙组8克/只/天。 2-17 calcium Group 2 Example Group 8 g / bird / day. 第18-33组为实施例3加钙组8克/只/天。 The first group was 18-33 Example 3 8 g calcium group / bird / day. 饲喂方法为自然取食,饲养时间为2周。 Natural feeding method of feeding, feeding for 2 weeks. 实验结果与结论如下: 对小白鼠股骨重、骨长和骨钙含量的影响 The experimental results and conclusions are as follows: Effects on mice weight femur bone calcium content and length

Figure CN105520135AD00051

CN 105520135 A 说明书4/4 页 CN 105520135 A description 4/4

Figure CN105520135AD00061

实验结果表明,本发明的食品对小鼠具有显著增加骨钙含量的作用。 Experimental results show that the food present invention have a significantly increased calcium content on mice.

Claims (4)

  1. 1. 一种保健食品,其特征是,所述食品由如下原料制成:维生素K2 2-8份,姜黄素3 -12 份,碳酸钙10-15份,酪蛋白磷酸肽4-5份,乳酸镁3-5份,全脂奶粉2-5份,淫羊藿5份, 多肽1-3份,羧甲基纤维素1份,硬脂酸镁1份。 1. A health food, characterized in that the food product prepared from the following ingredients: Vitamin K2 2-8 parts, 3-12 parts by curcumin, 10-15 parts of calcium carbonate, casein phosphopeptide 4-5 parts, 3-5 parts of magnesium lactate, 2-5 parts of whole milk powder, 5 parts of epimedium, 1-3 parts polypeptides, 1 part of carboxymethyl cellulose, 1 part of magnesium stearate.
  2. 2. 根据权利要求1所述的保健食品,其特征是,多肽为序列1-16任一所示的序列。 The health food according to claim 1, characterized in that the polypeptide is a sequence of any sequence 1-16 as shown.
  3. 3. 权利要求1或2所述的保健食品在制备用于提高骨骼钙含量的药物中的应用。 Application improve bone calcium content medicament health food according to claim 1 or 2 for the preparation.
  4. 4. 一种多肽,其特征是,为序列1-16任一所示的序列。 A polypeptide, characterized in that, in a sequence shown in any of sequence 1-16.
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CN102949710A (en) * 2012-05-08 2013-03-06 北京润康普瑞生物技术有限公司 Pharmaceutical composition or healthcare product for increasing bone mineral density and preparation method of pharmaceutical composition or healthcare product
CN102894372A (en) * 2012-11-05 2013-01-30 江苏江大源生态生物科技有限公司 Health-care food for increasing bone density and preparation method thereof
CN103103243A (en) * 2013-01-22 2013-05-15 广东环西生物科技股份有限公司 Method for preparing silkworm chrysalis peptide by conducting combined hydrolysis on free enzyme and immobilized enzyme
CN103736074A (en) * 2013-11-21 2014-04-23 荣成百合生物技术有限公司 Bone mineral density increase health capsule and preparation method thereof
CN104888192A (en) * 2015-04-30 2015-09-09 威海特伦斯生物工程有限公司 Sea cucumber glucosamine preparation for increasing bone mineral density, and production method thereof

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