CN105520135A - Healthy food with function of treating osteoporosis - Google Patents
Healthy food with function of treating osteoporosis Download PDFInfo
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- CN105520135A CN105520135A CN201510954489.0A CN201510954489A CN105520135A CN 105520135 A CN105520135 A CN 105520135A CN 201510954489 A CN201510954489 A CN 201510954489A CN 105520135 A CN105520135 A CN 105520135A
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- food
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- calcium
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Links
- 235000001497 healthy food Nutrition 0.000 title abstract 5
- 208000001132 Osteoporosis Diseases 0.000 title description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 46
- 229920001184 polypeptide Polymers 0.000 claims abstract description 42
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000011575 calcium Substances 0.000 claims abstract description 20
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 20
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 5
- 235000018905 epimedium Nutrition 0.000 claims abstract description 5
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims abstract description 5
- 229960004658 magnesium lactate Drugs 0.000 claims abstract description 5
- 239000000626 magnesium lactate Substances 0.000 claims abstract description 5
- 235000015229 magnesium lactate Nutrition 0.000 claims abstract description 5
- 235000008939 whole milk Nutrition 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract 2
- 235000013305 food Nutrition 0.000 claims description 42
- 235000013402 health food Nutrition 0.000 claims description 12
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 claims description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 4
- 241001016310 Epimedium grandiflorum Species 0.000 claims description 4
- PREBVFJICNPEKM-YDWXAUTNSA-N bisdemethoxycurcumin Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)CC(=O)\C=C\C1=CC=C(O)C=C1 PREBVFJICNPEKM-YDWXAUTNSA-N 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- JYTVKRNTTALBBZ-UHFFFAOYSA-N bis demethoxycurcumin Natural products C1=CC(O)=CC=C1C=CC(=O)CC(=O)C=CC1=CC=CC(O)=C1 JYTVKRNTTALBBZ-UHFFFAOYSA-N 0.000 claims description 2
- YXAKCQIIROBKOP-UHFFFAOYSA-N di-p-hydroxycinnamoylmethane Natural products C=1C=C(O)C=CC=1C=CC(=O)C=C(O)C=CC1=CC=C(O)C=C1 YXAKCQIIROBKOP-UHFFFAOYSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 20
- 238000010521 absorption reaction Methods 0.000 abstract description 7
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract description 4
- 239000005018 casein Substances 0.000 abstract description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract description 2
- 235000021240 caseins Nutrition 0.000 abstract description 2
- 239000004148 curcumin Substances 0.000 abstract description 2
- 229940109262 curcumin Drugs 0.000 abstract description 2
- 235000012754 curcumin Nutrition 0.000 abstract description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 241000893536 Epimedium Species 0.000 abstract 1
- 108010001441 Phosphopeptides Proteins 0.000 abstract 1
- PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 abstract 1
- 235000019143 vitamin K2 Nutrition 0.000 abstract 1
- 239000011728 vitamin K2 Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
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- 230000000694 effects Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000037182 bone density Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001009 osteoporotic effect Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000931705 Cicada Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000382353 Pupa Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 208000005250 Spontaneous Fractures Diseases 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000005786 degenerative changes Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention provides a healthy food, and belongs to the technical field of healthy foods. The healthy food is characterized by being prepared from the following raw materials in parts by weight: 2 parts of vitamin K2, 12 parts of curcumin, 10 parts of calcium carbonate, 5 parts of casein phosphopeptide, 3 parts of magnesium lactate, 5 parts of whole milk powder, 5 parts of epimedium, 1 part of polypeptide, 1 part of carboxymethyl cellulose and 1 part of magnesium stearate. The healthy food has the capability of improving calcium absorption, and has a great advantage to improvement of body bones.
Description
Technical field
The invention belongs to technical field of health care food, be specifically related to a kind of health food with health care.
Background technology
Chinese aging population support is numerous, and along with aging populations increases, the osteoporosis that the elderly occurs is more, and the fracture patient caused due to osteoporosis is every year more.More inconvenience is brought to the life of the elderly.Calcium forms the most important material of bone, and the calcium that human body absorbs from meals and nutriment, through osteoblastic effect, is deposited on bone, to ensure that bone is effectively strong.But bone not once be formed, just changes never again.Along with the increase at age, the level of digesting and assimilating of human body declines, there is change in hormonal readiness, calcium in bone can run off at leisure, cause bone to become soft, fragile, vertebral deformation, figure's distortion cause " curvature of the spinal column " and occur, with the symptom such as pain of whole body bone, being called osteoporosis, is a kind of skeletal diseases of general.Osteoporosis shows as back pain, pathologic fracture clinically.Shortage and the loss of calcium can generally occur after people in middle age.The elderly is due to basic metabolism decline, and anabolism reduces, and catabolism increases, and composition and decomposition metabolism disequilibrium, causes cell function to decline.Body fat is organized often to be increased along with the increase at age, and organizing beyond fat, reduces along with the increase at age, is in particular in: 1. in cell quantity decline body, moisture reduces; 3. bone tissue mineral matter reduces, and bone tissue amount reduces; 4. blood vessel hardens gradually; 5. hepatic and renal function and brain cell metabolism etc. also have decline internal system function in various degree to change and the weakening of Absorption And Metabolism function along with the increase at age, and cause the osteoporotic incidence of disease to increase, bone density is starkly lower than young people.Have bibliographical information, normal person grow up after bone tissue amount still can increase, 30-35 year between bone density reach peak value, decline gradually subsequently, to reducing 20-30% when 70 years old, therefore the elderly Yi Fa osteoporosis and fracture.The elderly reduces due to knuckle synovia, and soft tissue is constantly degenerated and worn and torn, and occurs a series of illness such as joint degenerative change, arthralgia, arthroncus, has a strong impact on the health of the elderly.
Preventing osteoporotic health products more at present, is simple replenishing the calcium mostly, but existing health products, and calcium absorptivity is lower, can not prevent bone-loss.
Therefore, necessary on the basis of prior art, a kind of component proportioning of R & D design is scientific and reasonable, can not only replenish the calcium, particularly can prevent the health products of bone-loss.
Summary of the invention
The object of the invention is a kind of health food with prevention of osteoporosis effect, by the combination of related nutritional thing, this product is had to be incorporated multiple different efficacies composition in product, and these compositions cooperatively interact, synergy, supplement skeleton nutrition comprehensively, promote calcium absorption, promote that collagen generates, prevent the calcium loss in bone, the generation of prevention of osteoporosis, to ensure that bone is effectively strong.
Technical scheme of the present invention: a kind of health food with prevention of osteoporosis effect, it is characterized in that, by weight: farnoquinone 2-8 part, bisdemethoxycurcumin 12 parts, calcium carbonate 10-15 part, CPP 4-5 part, magnesium lactate 3-5 part, whole milk powder 2-5 part, barrenwort 5 parts, polypeptide 1-3 part, carboxymethyl cellulose 1 part, dolomol 1 part.
For ensureing product quality, all operations all should carry out in the dry environment of cleaning.
Wherein CPP obtains by biotechnology the polypeptide that ー kind contains phosphate from bovine casein, has the physiologically active promoting absorption of human body calcium, can promote absorption and the utilization of calcium.
Technological merit of the present invention:
The present invention have developed the health food with prevention of osteoporosis effect, by above nutraceutical combination, this product is had to be incorporated multiple different efficacies composition in product, and these compositions cooperatively interact, synergy, supplement skeleton nutrition comprehensively, promote calcium absorption, promote that collagen generates, prevent the calcium loss in bone, the generation of prevention of osteoporosis, to ensure that bone is effectively strong.
So, the health food with prevention of osteoporosis effect of the present invention in adjustment function of human body, nutrition, supplement calcium be provided for bone, prevent in calcium loss etc. feature.
Detailed description of the invention
The acquisition of embodiment 1 polypeptide
Degreasing in acetone is dissolved in after cicada pupa is washed homogenate, centrifugal residue obtained water is made into suspension, suspension is heated 10 minutes at 90 ° of C, adjust pH to 8 after cooling, add papain and trypsin hydrolysis, hydrolysis time is 2.5h, temperature is 55 ° of C, pH value is 6.5, enzyme dosage is 1%, centrifugal or filtration gained supernatant is polypeptide solution, described polypeptide solution glucan G-50 (SephadexG-50) (1.5cm × 90cm) is separated, 20mmol/LHCl eluant solution, flow velocity 1.3mL/ minute, collect eluted product, regulate solution to pH7.0, 10000 revs/min centrifugal 15 minutes, supernatant freeze drying is for subsequent use, through sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), reclaim the band of small-molecular-weight, obtain the sequence of 38 little peptides altogether.Through checking, 16 little peptides are wherein had to have the function promoting calcium absorption.According to the peak separation time different in chromatographic column, corresponding little peptide can be obtained in batches.
CY-1-7:NQRYDYPCHVPVMQSVPYK；
CY-2-3:VGQSRVMALMTQFMSCRQ；
CY-1-9:WKSDQTDINSGGACGYQ；
CY-2-9:SKSVHDQEPYLWWNNP；
CY-2-13:PECHLSRFRFFPSQ；
CY-3-1:HPQPEGWKFAPWMHPAHQN；
CY-3-5:PLIINLSWRVSVWFHHSV；
CY-3-7:GRHCEQLRGAVEWASGS；
CY-3-11:SQPSSVGHHISLICRH；
CY-4-1:TVESQNPACVFPWE；
CY-4-3:SIWAEPWRFQHPNPNRWTW；
CY-4-5:NRSAWLISPHHGSQWTWR；
CY-4-7:ASWLGYARQRGWSGDAM；
CY-4-9:CWGRNCHPQTKCKIIV；
CY-4-13:YHKQDPRKCYCRSW；
CY-4-15:CNHCRHSHQWFWD.
The preparation 1 of embodiment 2 food
Get farnoquinone 2 parts, curcumin 12 parts, 10 parts, calcium carbonate, CPP 5 parts, magnesium lactate 3 parts, whole milk powder 5 parts, barrenwort 5 parts, polypeptide 1 part (getting the one of 16 kinds of little peptides), carboxymethyl cellulose 1 part, dolomol 1 part, mix, wear into fine powder, cross 120 mesh sieves, then sterilizing, packing, obtain health food of the present invention (16 kinds of small peptide productions become 16 kinds of corresponding food).
The preparation method 2 of embodiment 3 food
Get farnoquinone 8 parts, bisdemethoxycurcumin part, 15 parts, calcium carbonate, CPP 4 parts, magnesium lactate 5 parts, whole milk powder 2 parts, barrenwort 5 parts, polypeptide 3 parts (one of 16 kinds of little peptides), carboxymethyl cellulose 1 part, dolomol 1 part mixes, wear into fine powder, cross 120 mesh sieves, then sterilizing, packing, obtain health food of the present invention (16 kinds of small peptide productions become 16 kinds of corresponding food).
Embodiment 4 security detects
The food that embodiment 2 and 3 prepares is carried out security verification, according to the verification method of this area routine, can show that the present invention confirms safety non-toxic through animal experiment, experimental result and conclusion as follows:
(1) acute toxicity testing shows: according to acute toxicity dose grading standard, the non-toxic level in true border;
(2) Micronucleus test, sperm malformation test, Salmonella reversion test result are negative;
(3) 30 days feeding trials: animal used as test growing state is good, and hematological examination, biochemical analysis, main dirty body when histological indications, compared with control group, is showed no exception, proves safety non-toxic of the present invention.
Embodiment 5 promotes the experimental verification of calcium uptake
32 kinds of food that embodiment 2 and 3 is prepared, respectively feeding laboratory mouse.Carry out according to the safe toxicity test method of country's 2005 editions pharmacopeia.Mouse Weight is 18 20 grams, male and female half and half, often organizes 4.Test divides 17 groups.1st group is Normal group, conventional feed of feeding.2-17 group adds calcium group 8 grams/pcs/day for embodiment 2.18-33 group adds calcium group 8 grams/pcs/day for embodiment 3.Feeding method is that nature takes food, and feeding time is 2 weeks.Experimental result and conclusion as follows:
On the impact of small white mouse femur weight, bone length and calcium content of bone
| Average calcium content of bone (mg/g) | Femur mid point bone density (g/cm 2） | Femur distal end bone density (g/cm 2） | |
| Control group | 205.0 | 0.201 | 0.210 |
| The food of example 2-sequence 1 polypeptide | 240.3 | 0.230 | 0.245 |
| The food of example 2-sequence 2 polypeptide | 241.6 | 0.235 | 0.246 |
| The food of example 2-sequence 3 polypeptide | 243.5 | 0.233 | 0.247 |
| The food of example 2-sequence 4 polypeptide | 249.6 | 0.231 | 0.240 |
| The food of example 2-sequence 5 polypeptide | 247.6 | 0.237 | 0.243 |
| The food of example 2-sequence 6 polypeptide | 239.8 | 0.239 | 0.246 |
| The food of example 2-sequence 7 polypeptide | 241.5 | 0.238 | 0.248 |
| The food of example 2-sequence 8 polypeptide | 243.2 | 0.240 | 0.247 |
| The food of example 2-sequence 9 polypeptide | 243.6 | 0.241 | 0.243 |
| The food of example 2-sequence 10 polypeptide | 244.3 | 0.237 | 0.241 |
| The food of example 2-sequence 11 polypeptide | 244.0 | 0.249 | 0.243 |
| The food of example 2-sequence 12 polypeptide | 239.9 | 0.243 | 0.242 |
| The food of example 2-sequence 13 polypeptide | 240.7 | 0.237 | 0.243 |
| The food of example 2-sequence 14 polypeptide | 241.3 | 0.236 | 0.241 |
| The food of example 2-sequence 15 polypeptide | 241.5 | 0.238 | 0.250 |
| The food of example 2-sequence 16 polypeptide | 240.1 | 0.240 | 0.246 |
| The food of example 2-sequence 1 polypeptide | 242.8 | 0.236 | 0.243 |
| The food of example 3-sequence 2 polypeptide | 243.7 | 0.237 | 0.248 |
| The food of example 3-sequence 3 polypeptide | 244.8 | 0.235 | 0.247 |
| The food of example 3-sequence 4 polypeptide | 244.0 | 0.239 | 0.243 |
| The food of example 3-sequence 5 polypeptide | 243.1 | 0.231 | 0.240 |
| The food of example 3-sequence 6 polypeptide | 241.0 | 0.238 | 0.243 3 --> |
| The food of example 3-sequence 7 polypeptide | 241.7 | 0.237 | 0.246 |
| The food of example 3-sequence 8 polypeptide | 242.7 | 0.236 | 0.246 |
| The food of example 3-sequence 9 polypeptide | 240.6 | 0.234 | 0.241 |
| The food of example 3-sequence 10 polypeptide | 243.1 | 0.235 | 0.245 |
| The food of example 3-sequence 11 polypeptide | 240.6 | 0.241 | 0.246 |
| The food of example 3-sequence 12 polypeptide | 245.0 | 0.241 | 0.247 |
| The food of example 3-sequence 13 polypeptide | 239.7 | 0.239 | 0.250 |
| The food of example 3-sequence 14 polypeptide | 239.9 | 0.231 | 0.250 |
| The food of example 3-sequence 15 polypeptide | 240.6 | 0.234 | 0.246 |
| The food of example 3-sequence 16 polypeptide | 241.4 | 0.235 | 0.249 |
Experimental result shows, food of the present invention has the effect significantly increasing calcium content of bone to mouse.
Sequence table
The western cloud of < 110 > thunder
< 120 > mono-kind has the health food for the treatment of osteoporosis function
〈210〉1
〈211〉19
〈212〉PRT
〈400〉CY-1-7
NQRYDYPCHVPVMQSVPYK；
〈210〉2
〈211〉18
〈212〉PRT
〈400〉CY-2-3
VGQSRVMALMTQFMSCRQ；
〈210〉3
〈211〉17
〈212〉PRT
〈400〉CY-1-9
WKSDQTDINSGGACGYQ；
〈210〉4
〈211〉16
〈212〉PRT
〈400〉CY-2-9
SKSVHDQEPYLWWNNP；
〈210〉5
〈211〉14
〈212〉PRT
〈400〉CY-2-13
PECHLSRFRFFPSQ；
〈210〉6
〈211〉19
〈212〉PRT
〈400〉CY-3-1
HPQPEGWKFAPWMHPAHQN；
〈210〉7
〈211〉18
〈212〉PRT
〈400〉CY-3-5
PLIINLSWRVSVWFHHSV；
〈210〉8
〈211〉17
〈212〉PRT
〈400〉CY-3-7
GRHCEQLRGAVEWASGS；
〈210〉9
〈211〉16
〈212〉PRT
〈400〉CY-3-11
SQPSSVGHHISLICRH；
〈210〉10
〈211〉14
〈212〉PRT
〈400〉CY-4-1
TVESQNPACVFPWE；
〈210〉11
〈211〉19
〈212〉PRT
〈400〉CY-4-3
SIWAEPWRFQHPNPNRWTW；
〈210〉12
〈211〉18
〈212〉PRT
〈400〉CY-4-5
NRSAWLISPHHGSQWTWR；
〈210〉13
〈211〉17
〈212〉PRT
〈400〉CY-4-7
ASWLGYARQRGWSGDAM；
〈210〉14
〈211〉16
〈212〉PRT
〈400〉CY-4-9
CWGRNCHPQTKCKIIV；
〈210〉15
〈211〉14
〈212〉PRT
〈400〉CY-4-13
YHKQDPRKCYCRSW；
〈210〉16
〈211〉13
〈212〉PRT
〈400〉CY-4-15
CNHCRHSHQWFWD
Claims (4)
1. a health food, it is characterized in that, described food is made up of following raw material: farnoquinone 2-8 part, bisdemethoxycurcumin 12 parts, calcium carbonate 10-15 part, CPP 4-5 part, magnesium lactate 3-5 part, whole milk powder 2-5 part, barrenwort 5 parts, polypeptide 1-3 part, carboxymethyl cellulose 1 part, dolomol 1 part.
2. health food according to claim 1, is characterized in that, polypeptide is the arbitrary shown sequence of sequence 1-16.
3. the application of the health food described in claim 1 or 2 in the medicine for the preparation of raising skeletal calcium content.
4. a peptide species, is characterized in that, is the arbitrary shown sequence of sequence 1-16.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510954489.0A CN105520135A (en) | 2015-12-20 | 2015-12-20 | Healthy food with function of treating osteoporosis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510954489.0A CN105520135A (en) | 2015-12-20 | 2015-12-20 | Healthy food with function of treating osteoporosis |
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| CN105520135A true CN105520135A (en) | 2016-04-27 |
Family
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| CN201510954489.0A Pending CN105520135A (en) | 2015-12-20 | 2015-12-20 | Healthy food with function of treating osteoporosis |
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| CN (1) | CN105520135A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107348522A (en) * | 2017-08-14 | 2017-11-17 | 北京市营养源研究所 | A kind of alimentation composition for improving the elderly's kinematic system function and preparation method thereof |
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Application publication date: 20160427 |
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