CN107126554B - A kind of collagen product and its preparation method and application - Google Patents
A kind of collagen product and its preparation method and application Download PDFInfo
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- CN107126554B CN107126554B CN201710289770.6A CN201710289770A CN107126554B CN 107126554 B CN107126554 B CN 107126554B CN 201710289770 A CN201710289770 A CN 201710289770A CN 107126554 B CN107126554 B CN 107126554B
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- 108010035532 Collagen Proteins 0.000 title claims abstract description 203
- 229920001436 collagen Polymers 0.000 title claims abstract description 202
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 77
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims abstract description 77
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- 239000000843 powder Substances 0.000 claims abstract description 44
- 239000002994 raw material Substances 0.000 claims abstract description 36
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- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 24
- 206010014080 Ecchymosis Diseases 0.000 claims abstract description 11
- 208000001132 Osteoporosis Diseases 0.000 claims abstract description 11
- 230000002500 effect on skin Effects 0.000 claims abstract description 11
- 206010051131 Mastoptosis Diseases 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 39
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- 238000007873 sieving Methods 0.000 claims description 16
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- 238000005516 engineering process Methods 0.000 abstract description 10
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- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
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- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of collagen product and its preparation method and application.A kind of collagen product, raw material include bone collagen Gly-His-Lys, and raw material includes the following each component of parts by weight：16 parts of bone collagen Gly-His-Lys, 16 parts of collagen Gly-His-Lys, 0.5 2 parts of Cartilage collagen Gly-His-Lys, 0.1 1 parts of vitamin c powder.The preferred domestic and international best collagen raw material of collagen product of the present invention and the other raw materials for promoting internal collagen synthesis, scientific matching is carried out according to the principle of monarch, and processing technology is optimized, ensure that this product can surmount like product on the market in digestibility and internal utilization rate.Three months bone density improvement rates more than 98%, six months osteoporosis rehabilitation rates more than 87% can be made by taking the product of the present invention；Three months skin-tightening improvement rates more than 96%；Six months mastoptosis improvement rates more than 91%；Three months the dermal ecchymosis rehabilitation rates more than 98%.
Description
Technical field
The invention belongs to field of health care products, is related to a kind of collagen product and its preparation method and application.
Background technology
Due to diet and operating pressure, there is the osteoporosis because of collagen shortage, Dermatochalasia, blood vessel
The elderly to become fragile and young man are more and more.And collagen complementary goods is many on the market, there are collagen tablet, collagen egg
White powder, collagen oral liquid.It is used for the product to human body replenishing collagen above, some is difficult to digest, and some contents are too
Low, the unreasonable utilization rate in vivo of some formulas, some compositions are single, cause many people for lacking collagen to eat very long
The product of the collagen of time, it could not also change the osteoporosis caused by collagen lacks, Dermatochalasia, blood vessel become fragile rupture
Bleeding.Therefore there is an urgent need to a digestibility is high, internal utilization rate high energy quickly strengthens bone density, quickly improves skin in market
The collagen product of loose, the quick enhancing blood vessel elasticity of skin.Patent 201210120091.3 discloses a kind of egg containing ossein
White composition, hundred parts by weight meters, including following component：5 parts -12 parts of bone collagen；5 parts -12 parts of bone calcium；Gucosamine
40 parts -48 parts；30 parts -40 parts of chondroitin sulfate；2 parts -7 parts of cow tree resin acid.But the composition of the patent improve osteoporosis,
Dermatochalasia etc. effect is unsatisfactory.
The content of the invention
For overcome the deficiencies in the prior art, the present invention provides a kind of collagen product and its preparation method and application,
The problems such as improving osteoporosis, cutis laxa.
The invention provides following technical scheme：
A kind of collagen product, raw material include bone collagen Gly-His-Lys, it is characterised in that：It is as follows that raw material includes parts by weight
Each component：Bone collagen Gly-His-Lys 1-6 parts, collagen Gly-His-Lys 1-6 parts, Cartilage collagen Gly-His-Lys 0.5-2 parts, dimension
Raw plain C powder 0.1-1 parts.
In any of the above-described scheme preferably, raw material includes the following each component of parts by weight：Bone collagen Gly-His-Lys 2-5
Part, collagen Gly-His-Lys 2-5 parts, Cartilage collagen Gly-His-Lys 0.8-1.5 parts, vitamin c powder 0.3-0.8 parts.
In any of the above-described scheme preferably, raw material includes the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 3 parts of collagen Gly-His-Lys, 1 part of Cartilage collagen Gly-His-Lys, 0.5 part of vitamin c powder.
In any of the above-described scheme preferably, the collagen product is powder, pulvis, tablet, granule, soup
Any one in agent, oral liquid, lotion and beverage.
In any of the above-described scheme preferably, bone collagen peptide molecular weight is 500-1500 dalton；Fish skin collagen
Albumen peptide molecular weight is 500-1500 dalton；Chondrin former peptide is 500-1500 dalton.
The present invention also provides the preparation method of described collagen product, and the collagen product is tablet, including
Following steps：
(1) by the bone collagen Gly-His-Lys, the collagen Gly-His-Lys, the Cartilage collagen Gly-His-Lys, institute
Vitamin c powder is stated by 50-100 mesh sieves were matched, all raw materials are weighed after sieving；
(2) the load weighted raw material of step (1) being mixed, incorporation time be 10-20 minutes, 10-30 turns of mixer rotating speed/
Point；
(3) materials result for mixing step (2), tableting pressure are thousand Ns of 4-5, and loading 6.5-6.8mm, every net
1 gram of content, check a net content within every 10 minutes, it is desirable to which net content reaches between 1.02-1.05 grams；
(4) the good collagen tablet of step (3) tabletting is packed, bottle neck aluminium foil sealing, vanning；
(5) after packing, qualified storage is detected in product laboratory.
In such scheme preferably, bone collagen Gly-His-Lys described in step (1), the collagen peptide
Powder, the Cartilage collagen Gly-His-Lys, the vitamin c powder cross 80 mesh sieves.
In any of the above-described scheme preferably, in step (2), incorporation time is 15 minutes, 20 turns of mixer rotating speed/
Point.
In any of the above-described scheme preferably, in step (2), mixing uses CH-200 mixers.
In any of the above-described scheme preferably, in step (3), the material that step (2) is mixed carries out tabletting, tabletting
Pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram.
In any of the above-described scheme preferably, in step (3), using tabletting machine, the model ZPW- of tablet press machine
19B。
In any of the above-described scheme preferably, in step (4), the good collagen tablet of tabletting is packed, every bottle
60 grams are filled, every bottle puts one bag of 2 grams of drier, bottle neck aluminium foil sealing, and the collagen tablet sealed is labelled, cased.
The preparation for being used to treat medicine for treating osteoporosis of collagen product of the present invention.
The preparation for being used to treat mastoptosis medicine of collagen product of the present invention.
The preparation for being used to treat the dermal ecchymosis medicine of collagen product of the present invention.
The preparation for being used to treat osteoporosis health products of collagen product of the present invention.
The preparation for being used to treat mastoptosis health products of collagen product of the present invention.
The preparation for being used to treat the dermal ecchymosis health products of collagen product of the present invention.
The feature hydroxyl dried meat amino acid content of bone collagen peptide protrudes, and can promote the formation of bone, under enhancing low calcium is horizontal
Gelatine original structure, so as to improve bone strength, that is, pre- anti-osteoporosis are haveed the function that；Keep the moisture of bone；Maintain
The toughness of bone；Repair skeletal injury.Bone collagen peptide is that the os osseum collagen of sheep is manufactured after proteasome degradation is handled, tool
There is the higher property digested and assimilated, molecular weight is about in 1000 dalton.
Rely amino acid containing a large amount of hydroxyl dried meat amino acid and hydroxyl in Cartilage collagen peptide, promote the formation of cartilage；Pin soft
Moisture in bone；Maintain the toughness of cartilage；Repair the damage of cartilage.Chondrin former peptide is the Cartilage collagen of sheep through protease
Made of after degraded, there is the higher property digested and assimilated, molecular weight is about in 1000 dalton.
The good water holding capacity of collagen makes skin water profit glossy；It is filled between dermis of skin, increases skin
Tight ness rating, skin tension is produced, reduce pore, make skin tight and high resilience；Skin corium cell growth can effectively be accelerated, it is living
Change epidermal cell, keep elasticity of skin and compactedness, prevent wrinkle from occurring, make skin health beautiful, careful and transparent feel is presented；
The collagen made an addition in cosmetics, they have good affinity and compatibility with skin, can infiltrate through skin epidermis,
Can be formed epithelium, protection skin, give skin moisten and flexibility, promote its pore shrink it is careful；Active deep-sea fish hide glue
Former albumen can directly penetrate into skin bottom, and good with the compatibility of surrounding tissue, can helper cell be manufactured into collagen, promote
Skin Cell normal growth；Supplement effect of the deep-sea fish skin collagen to the whole nutritious health care of breast entity.Fish skin collagen
Protein peptides are that japanese eel skin is manufactured after proteasome degradation, have the higher property digested and assimilated, molecular weight is about in 1000 dongles
.
The preferred domestic and international best collagen raw material of collagen product of the present invention and promote internal collagen
Other raw materials of synthesis, scientific matching is carried out according to the principle of monarch, and optimize processing technology, ensure that this product is disappearing
Like product on the market can be surmounted by changing absorptivity and internal utilization rate.Taking the product of the present invention can change three months bone densities
Kind rate more than 98%, six months osteoporosis rehabilitation rates more than 87%；Three months skin-tightening improvement rates more than 96%；Six months
Mastoptosis improvement rate more than 91%；Three months the dermal ecchymosis rehabilitation rates more than 98%.
Embodiment
In order to further appreciate that the technical characteristic of the present invention, the present invention is explained in detail with reference to specific embodiment
State.Embodiment only to the present invention have the function that it is exemplary, without the effect of any restrictions, those skilled in the art
The modification for any unsubstantiality made on the basis of the present invention, should all belong to protection scope of the present invention.
Quite Tetramune Limited Liability is public purchased from Nei Monggol peptide for bone collagen Gly-His-Lys, Cartilage collagen Gly-His-Lys
Department, model are respectively：Q/XMTS0012S、Q/XMTS0007S；Collagen Gly-His-Lys exist purchased from Shanghai pattern up to biotechnology
Limit company, model：X1X080206607.
Embodiment 1：
A kind of collagen product, raw material include the following each component of parts by weight：3 parts of bone collagen Gly-His-Lys, fish glue from skin
Former 3 parts of protein peptide powder, 1 part of Cartilage collagen Gly-His-Lys, 0.5 part of vitamin c powder.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 80 mesh of sieving, all materials electronic scale between weighing after sieving by technology preparation
Weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 15 minutes by technological requirement and release material with stainless steel cask, 20 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
The product of the present embodiment is taken, three months bone density improvement rates 99.5% of patient can be made；Skin-tightening changes within three months
Kind rate 98%；Three months the dermal ecchymosis rehabilitation rates 99.2%.
Embodiment 2：
A kind of collagen product, raw material include the following each component of parts by weight：2 parts of bone collagen Gly-His-Lys, fish glue from skin
Former 5 parts of protein peptide powder, 0.8 part of Cartilage collagen Gly-His-Lys, 0.8 part of vitamin c powder.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 80 mesh of sieving, all materials electronic scale between weighing after sieving by technology preparation
Weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 15 minutes by technological requirement and release material with stainless steel cask, 20 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
The product of the present embodiment is taken, three months bone density improvement rates 99.1% of patient can be made；Skin-tightening changes within three months
Kind rate 97.5%；Three months the dermal ecchymosis rehabilitation rates 99.0%
Embodiment 3：
A kind of collagen product, raw material include the following each component of parts by weight：5 parts of bone collagen Gly-His-Lys, fish glue from skin
Former 2 parts of protein peptide powder, 1.5 parts of Cartilage collagen Gly-His-Lys, 0.3 part of vitamin c powder.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 80 mesh of sieving, all materials electronic scale between weighing after sieving by technology preparation
Weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 15 minutes by technological requirement and release material with stainless steel cask, 20 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
The product of the present embodiment is taken, three months bone density improvement rates 99.0% of patient can be made；Skin-tightening changes within three months
Kind rate 97.1%；Three months the dermal ecchymosis rehabilitation rates 98.6%.
Embodiment 4：
A kind of collagen product, raw material include the following each component of parts by weight：1 part of bone collagen Gly-His-Lys, fish glue from skin
Former 6 parts of protein peptide powder, 0.5 part of Cartilage collagen Gly-His-Lys, 1 part of vitamin c powder.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 80 mesh of sieving, all materials electronic scale between weighing after sieving by technology preparation
Weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 15 minutes by technological requirement and release material with stainless steel cask, 20 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
The product of the present embodiment is taken, three months bone density improvement rates 98.6% of patient can be made；Skin-tightening changes within three months
Kind rate 96.8%；Three months the dermal ecchymosis rehabilitation rates 98.4%.
Embodiment 5：
A kind of collagen product, raw material include the following each component of parts by weight：6 parts of bone collagen Gly-His-Lys, fish glue from skin
Former 1 part of protein peptide powder, 2 parts of Cartilage collagen Gly-His-Lys, 0.1 part of vitamin c powder.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 80 mesh of sieving, all materials electronic scale between weighing after sieving by technology preparation
Weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 15 minutes by technological requirement and release material with stainless steel cask, 20 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
The product of the present embodiment is taken, three months bone density improvement rates 98.2% of patient can be made；Skin-tightening changes within three months
Kind rate 96.3%；Three months the dermal ecchymosis rehabilitation rates 98.1%.
Embodiment 6：
The present embodiment and the difference of embodiment 4 are：The difference of preparation method.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 50 mesh of sieving, all materials electronic scale between weighing after sieving by technology preparation
Weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 10 minutes by technological requirement and release material with stainless steel cask, 10 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 4,000 Ns, loading 6.5mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
Embodiment 7：
The present embodiment and the difference of embodiment 5 are：The difference of preparation method.
The preparation method of the present embodiment collagen product, including following steps：
(1) the said goods examine qualified raw material bone collagen peptide powder, collagen Gly-His-Lys, Cartilage collagen
Gly-His-Lys, vitamin c powder are matched in batch plant 100 mesh of sieving by technology preparation, and all materials use electronics between weighing after sieving
Scale is weighed；
(2) weighing workshop material pass-through box has been weighed and has been delivered to groove profile compound department, material is launched to CH-200 and mixed
In conjunction machine, set incorporation time 20 minutes by technological requirement and release material with stainless steel cask, 30 revs/min；
(3) material pass-through box will be mixed and be delivered to the progress tabletting of tabletting workshop, tablet press machine model ZPW-19B, tablet press machine
Pressure is 5,000 Ns, loading 6.8mm, every 1 gram of net content, checks a net content within every 10 minutes, it is desirable to which net content reaches
1.02-1.05 between gram；
(4) the good collagen tablet pass-through box of tabletting is packed between interior hired car, per bottled 60 grams, every bottle puts one bag
2 grams of drier, bottle neck aluminium foil sealing, the collagen tablet sealed are delivered to outer packing workshop and labelled, cased；
(5) the collagen tablet bottle that interior bag transmits is labelled, the label coding date of manufacture, posts label collagen
Piece loads big case, per 120 bottles of box installed；
(6) qualified storage is detected in product laboratory.
Experimental example 1：Treat osteoporosis clinical test
1st, sample：
Trial target 1-5 is the collagen product of 1-5 embodiments of the present invention.
Reference substance 1：A kind of collagen product, raw material include the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 4 parts of collagen Gly-His-Lys, 0.5 part of vitamin c powder.Preparation method is same as Example 1.
Reference substance 2：A kind of collagen product, raw material include the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 3 parts of collagen Gly-His-Lys, 7 parts of Cartilage collagen Gly-His-Lys, 0.5 part of vitamin c powder.Preparation method and the phase of embodiment 1
Together.
Reference substance 3：A kind of collagen product, raw material include the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 3 parts of collagen Gly-His-Lys, 1 part of Cartilage collagen Gly-His-Lys.Preparation method is same as Example 1.
Reference substance 4：The tablet prepared using the collagen composition of the embodiment 3 of patent 201410230390.1, often
1 gram of piece net content.
2nd, diagnostic criteria cardinal symptom：Ostalgia, pain in back and loin, leg knees soreness, easily fracture, talagia or has night
Arrange myenteron spasm.X-ray is acted normally or Bone density reduces, cortex of bone is thinning, bone trabecula reduction attenuates or has Thoracolumbar disk body
In the wedge shaped change of concave-concave shape or front.Bone mineral density T >=-2.5.
3rd, test method：
Selection meets 270 volunteers of diagnostic criteria, male 135 people, the people of female 135, average age 55 years old.By volunteer with
Machine is equally divided into 9 groups, no difference of science of statistics between each group, respectively test group 1-5 and control group 1-4.Test group 1-5 takes respectively
Tablet prepared by embodiment 1-5, takes 2 times, 1 tablet once, continuously takes 30 days daily.Control group 1-4 takes reference examples respectively
Tablet prepared by 1-4, takes 2 times, 1 tablet once, continuously takes 6 months daily.
4th, criterion of therapeutical effect
It is effective：The symptoms such as lumbago, local pain disappear substantially, and walking lumbago disappears；
Effectively：The symptoms such as lumbago, local pain substantially eliminate, and walking pain has mitigated；
It is invalid：The symptoms such as lumbago, local pain are not improved.
Clinical effectiveness is shown in Table 1.
Table 1, clinical test results
| Sample | It is effective | Effectively | It is invalid | Total effective rate |
| Trial target 1 | 29 | 0 | 1 | 96.7% |
| Trial target 2 | 27 | 1 | 2 | 93.3% |
| Trial target 3 | 26 | 2 | 2 | 93.3% |
| Trial target 4 | 24 | 3 | 3 | 90.0% |
| Trial target 5 | 24 | 2 | 4 | 86.7% |
| Reference substance 1 | 18 | 3 | 9 | 70.0% |
| Reference substance 2 | 15 | 4 | 11 | 63.3% |
| Reference substance 3 | 16 | 4 | 10 | 66.7% |
| Reference substance 4 | 20 | 3 | 7 | 76.7% |
Experimental example 2：Improve mastoptosis clinical test
1st, sample：
Trial target 1-5 is the collagen product of 1-5 embodiments of the present invention.
Reference substance 1：A kind of collagen product, raw material include the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 4 parts of collagen Gly-His-Lys, 0.5 part of vitamin c powder.Preparation method is same as Example 1.
Reference substance 2：A kind of collagen product, raw material include the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 3 parts of collagen Gly-His-Lys, 7 parts of Cartilage collagen Gly-His-Lys, 0.5 part of vitamin c powder.Preparation method and the phase of embodiment 1
Together.
Reference substance 3：A kind of collagen product, raw material include the following each component of parts by weight：Bone collagen Gly-His-Lys 3
Part, 3 parts of collagen Gly-His-Lys, 1 part of Cartilage collagen Gly-His-Lys.Preparation method is same as Example 1.
2nd, study subject：Selecting the women of 280 breast hanging downs, experimenter's age is 20-45 year, will be certainly as experimenter
Hope person's stochastic averagina part is 8 groups, every group of 35 people, respectively test group 1-5 and control group 1-3, no difference of science of statistics between each group.Sentence
The standard for room situation of weaning is as follows：
(1) standard breast, should possess：It is plentiful, tall and straight, flexible, in hemispherical；Breast position is in 2-6 intercostals, nipple
Positioned at the 4th intercostal；The diameter 10-12cm of breast basal surface, two teat spacings are more than 20cm；A quarter breast axle is (from basal surface
To the height of nipple) it is 5-6cm；Bust is equal to hip circumference.
(2) breast relaxation is sagging：Under newborn axial direction, breast tension force, elastic force reduce.If teat placement is less than reflexed below breast
Line is that l degree is sagging, and teat placement is 2 degree sagging less than the 6th arcus costarum edge, and teat placement is sagging for 3 degree up to umbilical region.
Measuring method：Testee stands naturally, and bipod is separately wide with shoulder, and both shoulders loosen, and upper limbs naturally droops, by mark
Upper limb, around a circle, measures bust through back shoulder foot bone inferior horn lower edge to front；Mark is measured into breast by nipple to clavicle midpoint
Head position；Mark is exceeded to the vertical range of sternal plane through nipple measurement breast, measures newborn axle height；By mark by nipple extremely
Breast inner side, outside, measure breast basal surface diameter.
Test group 1-5 takes the tablet of embodiment 1-5 preparations respectively, takes daily 2 times, 1 tablet once, continuously takes 6
Month, intermenstrual period disabling.Control group 1-3 takes the tablet of reference examples 1-3 preparations respectively, takes daily 2 times, 1 tablet once, continuously
Take 6 months, intermenstrual period disabling.
4th, criterion of therapeutical effect
It is effective：Bust increases more than 5cm, or breast above carries more than 3cm；；
Effectively：Bust increases 1-5cm, or breast above carries 1-3cm；
It is invalid：Bust increases or breast above carries below 1cm.
After 6 months, experimenter's chest result of variations is shown in Table 2.
Table 1, clinical test results
| Sample | It is effective | Effectively | It is invalid | Total effective rate |
| Trial target 1 | 34 | 0 | 1 | 97.1% |
| Trial target 2 | 30 | 3 | 2 | 94.3% |
| Trial target 3 | 31 | 2 | 1 | 94.3% |
| Trial target 4 | 24 | 8 | 3 | 91.4% |
| Trial target 5 | 27 | 5 | 3 | 91.4% |
| Reference substance 1 | 18 | 8 | 9 | 74.3% |
| Reference substance 2 | 15 | 10 | 10 | 71.4% |
| Reference substance 3 | 21 | 6 | 8 | 77.1% |
Claims (17)
1. a kind of collagen product, raw material includes bone collagen Gly-His-Lys, it is characterised in that：It is following that raw material includes parts by weight
Each component：Bone collagen Gly-His-Lys 1-6 parts, collagen Gly-His-Lys 1-6 parts, Cartilage collagen Gly-His-Lys 0.5-2 parts, dimension life
Plain C powder 0.1-1 parts.
2. collagen product according to claim 1, it is characterised in that：Raw material includes the following each component of parts by weight：
Bone collagen Gly-His-Lys 2-5 parts, collagen Gly-His-Lys 2-5 parts, Cartilage collagen Gly-His-Lys 0.8-1.5 parts, vitamin c powder
0.3-0.8 parts.
3. collagen product according to claim 1, it is characterised in that：Raw material includes the following each component of parts by weight：
3 parts of bone collagen Gly-His-Lys, 3 parts of collagen Gly-His-Lys, 1 part of Cartilage collagen Gly-His-Lys, 0.5 part of vitamin c powder.
4. collagen product according to any one of claim 1 to 3, it is characterised in that：The collagen product
For any one in powder, pulvis, tablet, granule, decoction, oral liquid, lotion and beverage.
5. the preparation method of collagen product according to any one of claim 1 to 4, the collagen product are
Tablet, including following steps：
(1) by the bone collagen Gly-His-Lys, the collagen Gly-His-Lys, the Cartilage collagen Gly-His-Lys, the dimension
Raw plain C powder was by 50-100 mesh sieves were matched, and all raw materials are weighed after sieving；
(2) the load weighted raw material of step (1) is mixed, incorporation time is 10-20 minutes, 10-30 revs/min of mixer rotating speed；
(3) materials result for mixing step (2), tableting pressure are thousand Ns of 4-5, loading 6.5-6.8mm, every net content
1 gram, check a net content within every 10 minutes, it is desirable to which net content reaches between 1.02-1.05 grams；
(4) the good collagen tablet of step (3) tabletting is packed, bottle neck aluminium foil sealing, vanning；
(5) after packing, qualified storage is detected in product laboratory.
6. the preparation method of collagen product according to claim 5, it is characterised in that：Gelatine described in step (1)
Former protein peptide powder, the collagen Gly-His-Lys, the Cartilage collagen Gly-His-Lys, the vitamin c powder cross 80 mesh sieves.
7. the preparation method of collagen product according to claim 5, it is characterised in that：In step (2), incorporation time
For 15 minutes, 20 revs/min of mixer rotating speed.
8. the preparation method of collagen product according to claim 5, it is characterised in that：In step (2), mixing uses
CH-200 mixers.
9. the preparation method of collagen product according to claim 5, it is characterised in that：In step (3), by step
(2) material mixed carries out tabletting, and tableting pressure is 4.8 thousand Ns, loading 6.7mm, every 1 gram of net content, every 10 minutes
Check a net content, it is desirable to which net content reaches between 1.02-1.05 grams.
10. the preparation method of collagen product according to claim 5, it is characterised in that：In step (3), using pressure
Piece machine tabletting, the model ZPW-19B of tablet press machine.
11. the preparation method of collagen product according to claim 5, it is characterised in that：In step (4), by tabletting
Good collagen tablet is packed, and per bottled 60 grams, every bottle puts one bag of 2 grams of drier, bottle neck aluminium foil sealing, the glue sealed
Former albumen flakes is labelled, vanning.
12. the system for being used to treat medicine for treating osteoporosis of collagen product according to any one of claim 1 to 4
It is standby.
13. the system for being used to treat mastoptosis medicine of collagen product according to any one of claim 1 to 4
It is standby.
14. the system for being used to treat the dermal ecchymosis medicine of collagen product according to any one of claim 1 to 4
It is standby.
15. the system for being used to treat osteoporosis health products of collagen product according to any one of claim 1 to 4
It is standby.
16. the system for being used to treat mastoptosis health products of collagen product according to any one of claim 1 to 4
It is standby.
17. the system for being used to treat the dermal ecchymosis health products of collagen product according to any one of claim 1 to 4
It is standby.
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| CN107510618A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide pleura and preparation method |
| CN109106944B (en) * | 2018-10-10 | 2021-12-07 | 北京盛美诺生物技术有限公司 | Composition for preventing and treating osteoarthritis and application thereof |
| CN111387397A (en) * | 2020-04-15 | 2020-07-10 | 湖北瑞邦生物科技有限公司 | Bovine bone peptide beverage for improving skeleton and preparation method thereof |
| CN112195214B (en) * | 2020-09-01 | 2021-12-03 | 华南理工大学 | Fish skin collagen polypeptide and preparation method and application thereof |
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| CN101130067A (en) * | 2007-07-20 | 2008-02-27 | 北京世纪博康医药科技有限公司 | Preparation for replenishing collagen and method of preparing the same |
| CN101887078A (en) * | 2009-05-14 | 2010-11-17 | 上海市南洋中学 | Magnetoelectric multimeter for laser electrostatic measurement |
| CN102091322A (en) * | 2009-12-14 | 2011-06-15 | 博辉生物药业(深圳)有限公司 | Compound preparation of collagen tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130067A (en) * | 2007-07-20 | 2008-02-27 | 北京世纪博康医药科技有限公司 | Preparation for replenishing collagen and method of preparing the same |
| CN101887078A (en) * | 2009-05-14 | 2010-11-17 | 上海市南洋中学 | Magnetoelectric multimeter for laser electrostatic measurement |
| CN102091322A (en) * | 2009-12-14 | 2011-06-15 | 博辉生物药业(深圳)有限公司 | Compound preparation of collagen tablet and preparation method thereof |
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