CN107510618A - A kind of complex polypeptide pleura and preparation method - Google Patents
A kind of complex polypeptide pleura and preparation method Download PDFInfo
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- CN107510618A CN107510618A CN201710797797.6A CN201710797797A CN107510618A CN 107510618 A CN107510618 A CN 107510618A CN 201710797797 A CN201710797797 A CN 201710797797A CN 107510618 A CN107510618 A CN 107510618A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
The invention discloses a kind of complex polypeptide pleura to include hermetic bag, film paper and film liquid, and the film liquid includes following components by weight percentage：0.1 10 parts of milk peptides, 0.1 10 parts of pilose antler peptides, 0.1 10 parts of collagen peptides, 5 20 parts of NMFs, 0.1 2 parts of essential oils, 13 parts of natural extracts, 25 portions of preservatives and the water for supplying 100 parts, the film liquid also include the thickener that regulation viscosity is 400 450mpas.The complex polypeptide pleura active component is the component that can be preferably absorbed by skin by pore, moisturizing ingredient good penetrability, can effectively pin the moisture of chest skin, promote the development of thymus gland；Small to skin irritation without allergy and hormone, use will not form dependence.Present invention also offers the preparation method of the complex polypeptide pleura.
Description
Technical field
The present invention relates to a kind of cosmetic technical field, more particularly to a kind of complex polypeptide pleura and preparation method.
Background technology
U.S. chest refers to the health that women is possessed, plentiful, mellow and full, strong chest.Attachment modern female is good for for chest
Health and vigorous and graceful growing interest, U.S. chest means in the market emerge in an endless stream, and are concentrated mainly on oral hormone, coating, injection, vacation
Body is filled, and while chest enlarge effect is advertised, also have ignored hiding health risk.
Chest enlarge is not that everybody is applicable, but should have certain specific aim, and such as born ateliosis, is exactly people
Described small chest person；Or due to thoracic operation, the patient of breast excision；Or because unexpected injury causes the imperfect person of breast；
Or there is the patient of mastatrophy after fertility；Or the imperfect person of breast, as breast have it is slight sagging and anisopleual.Cause
The applicability of the insertion type means such as the difference of its Different Individual, operation is also not ideal.
And some be known as chest enlarge means such as dietotherapy, massage etc. of rich insertion type also because work it is slow, be difficult to adhere to the problems such as, and
Not by too big high praise.Such as dietotherapy, because individual is different to the absorbing state of food nutrition, effect is also difficult to expect.Massage
Whether can produce mutually with regard to the effect of, also on certain procedures exist query.
Also occurs the pleura of a small amount of sticking type on the market at present, in a manner of similar facial mask, being attached at chest
Surface, the effect of to reach moisturizing, whitening, chest enlarge.And generally there is problems with these pleuras：1) it is most of be moisturizing into
Point, effect is difficult to persistently, and effect disappears quickly after deactivation；2) absorptivity of active ingredient is low, especially for can promote chest
The high molecular absorbability such as plentiful collagen is very pessimistic；3) dependence may be produced containing such as hormone in part
Insecurity composition.
The content of the invention
For overcome the deficiencies in the prior art, an object of the present invention is the complex polypeptide chest that absorbability is good, safe
Film.
The second object of the present invention is the preparation method for providing the pleura.
An object of the present invention adopts the following technical scheme that realization：
A kind of complex polypeptide pleura, including hermetic bag, film paper and film liquid, film liquid is including by weight percentage with the following group
Point：0.1-10 parts milk peptide, 0.1-10 part pilose antlers peptide, 0.1-10 parts collagen peptide, 5-20 parts NMF, 0.1-2 parts essential oil, 1-3
Part natural extract, 2-5 parts preservative and the water for supplying 100 parts, film liquid also include the increasing that regulation viscosity is 400-450mpas
Thick dose.
Further, in milk peptide and pilose antler peptide and collagen peptide, the content of oligopeptides is more than 85%.
Further, thickener is Ka Bomu or xanthans.
Further, NMF be one or both of glycerine, propane diols, butanediol, hyaluronic acid and D-pantothenyl aleohol with
On.
Further, natural extract includes red sage root powder extracts.
Further, preservative is tea oil.
Further, the material of film paper is non-woven fabrics, is provided with hermetic bag and meets oxygen spontaneous heating interlayer.
Further, film liquid includes following components by weight percentage：5 parts of milk peptides, 5 parts of pilose antler peptides, 5 parts of collagens
Peptide, 2 parts of D-pantothenyl aleohols, 10 parts of butanediols, 1 part of lavender essential oil, 2 parts of red sage root powder extracts and 3 parts of tea oil, film liquid also include regulation
Viscosity is 400-450mpas thickener.
The second object of the present invention adopts the following technical scheme that realization：
A kind of method for preparing above-mentioned complex polypeptide pleura, comprises the following steps：
1) NMF of formula ratio, preservative is taken to add the water of 1-3 times of volume to mix well；
2) liquid material obtained to step 1), while water is added dropwise, while adding milk peptide, pilose antler peptide, the glue of formula ratio
Former peptide, mix well；
3) in the liquid material obtained to step 2), essential oil and natural extract is added, is mixed well；
4) in the liquid material obtained to step 3), it is 400-450mpas to add thickener and adjust viscosity；
5) the film liquid impregnated membranes paper obtained using step 4), is loaded into hermetic bag, seals.
Further, in step 5), in impregnation steps, using 2-4 atm malleation.
Compared with prior art, the beneficial effects of the present invention are：
1) complex polypeptide pleura provided by the invention, active component are the group that can be preferably absorbed by skin by pore
Point, moisturizing ingredient good penetrability, it can effectively pin the moisture of chest skin, promote the development of thymus gland；
2) complex polypeptide pleura provided by the invention, to reach the effect of whitening, moisturizing, chest enlarge by way of sample combination
Fruit, i.e., on the basis of the blood circulation of chest, the metabolism of cell is promoted, then chest is stimulated to develop again；
3) complex polypeptide pleura provided by the invention, it is small to skin irritation without allergy and hormone, using not
Dependence can be formed.
Embodiment
Below, with reference to embodiment, the present invention is described further, it is necessary to which explanation is, what is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
In detailed description below, such as non-specified otherwise, used reagent or material can be by commercially available or conventional
The mode of research technique obtains.
The present invention provides a kind of complex polypeptide pleura, including hermetic bag, film paper and film liquid, and film liquid is included by weight percentage
The following components of meter：0.1-10 parts milk peptide, 0.1-10 part pilose antlers peptide, 0.1-10 parts collagen peptide, 5-20 parts NMF, 0.1-2
Part essential oil, 1-3 parts natural extract, 2-5 parts preservative and the water for supplying 100 parts, it is 400- that film liquid, which also includes regulation viscosity,
450mpas thickener.
In the formula, milk peptide derives from cow's milk, can be directly by intestinal absorption, and is absorbed on the premise of being not required to through digestion
Into blood, quick production capacity.The class morphine active component contained in milk peptide can accelerate cell movement, improve the work(such as immunocompetence
Energy.
In pilose antler, the accounting of amino acid is up to more than 50%, also containing phosphatide, glycolipid, glue fat, hormone, aliphatic acid, amino
The composition such as sour, protein and calcium, phosphorus, magnesium, sodium.The stagnation resolvation myogenic of the medicinal efficacy of pilose antler, pilose antler have promoting circulation of blood, stagnation resolvation, detumescence, solution
The effect of poison and myogenic.Therefore, it is usually used in treating a variety of diseases such as boil and traumatology traumatic injury, it is especially chronic prolonged
Unhealed, curative effect is more preferably.Experiment shows that pilose antler to that not more with newborn bad ulcer and wound, can strengthen it and regenerate for a long time
Journey, strengthen the metabolism of nitrogen and carbohydrate, so as to promote the healing acceleration of ulcer surface and fracture.
Oligopeptides can be preferably absorbed by the skin in pilose antler peptide, it is possible to increase the antioxidation activity of Skin Cell, promote chest
The metabolism of cell, so that cell is fuller full.
Collagen peptide can more effectively penetrate into cuticula, skin corium, play and extend the Skin Cell life-span, suppress cell membrane lipid
Matter peroxidating, attack of the resistance oxyradical to DNA, the activity for suppressing tyrosine, improve cutaneous immunisation ability, improve skin
The multiple efficacies such as water holding water holding capacity, the synthesis for promoting collagen and the synthesis of dermal cell hyaluronic acid.Can be by human body actively
And accessible absorption, without digestion, made full use of for bodily tissue.
In this formula, milk peptide, pilose antler peptide and collagen peptide three are combined, and permanent moisturizing, lock are provided for breast tissue
Water effect；Go deep into inside breast tissue, promote the development of breast fat cell, thymus gland together with effective component, with up to full, beautiful
White purpose.
Milk peptide, pilose antler peptide and collagen peptide refer to the hydrolysate that molecular weight is less than 1000, i.e. oligopeptides group in this formula
Divide and be not less than 85%.
Embodiment 1：
A kind of complex polypeptide pleura, including hermetic bag, film paper and film liquid, film liquid is including by weight percentage with the following group
Point：5 parts of milk peptides, 5 parts of pilose antler peptides, 5 parts of collagen peptides, 2 parts of D-pantothenyl aleohols, 10 parts of butanediols, 1 part of lavender essential oil, 2 parts of danshen powders
Extract and 4 parts of tea oil, film liquid also include the Ka Bomu that regulation viscosity is 420mpas；Wherein milk peptide, pilose antler peptide and collagen
In peptide, the content of oligopeptides is more than 85%.
The method for preparing the complex polypeptide pleura, comprises the following steps：
1) the 20gD- panthenols and 10g butanediols, 30g tea oil for taking formula ratio add 100mL water to mix well；
2) liquid material obtained to step 1), while water is added dropwise, while adding 50g milk peptides, 50g pilose antlers peptide, 50g glue
Former peptide, mix well, add water to complement to 1L；
3) in the liquid material obtained to step 2), 10g lavender essential oils and 20g red sage root powder extracts is added, are mixed well；
4) in the liquid material obtained to step 3), it is 420mpas to add Ka Bomu and adjust viscosity；
5) film liquid obtained using step 4) immerses film paper, accelerates dipping using 3 atm malleations, will impregnate complete film
Paper loads spontaneous heat-sealable pouch, sealing.
Complex polypeptide pleura in the present embodiment, without traditional harmful preservative, but using both had
Nourishes effect has the natural antiseptic agent tea oil of antisepsis again, can with maximum reduce the cause of the complex polypeptide pleura
Quick property, it is safer, more effective.
Complex polypeptide pleura provided by the invention, this method can effectively keep each component, obtained after birth liquid matter
Ground uniform and smooth, good to the permeability of skin, active ingredient preferably can be absorbed by the skin through pore.Using spontaneous heat seal
Bag, when in use, after tearing hermetic bag, the chance oxygen spontaneous heating material in hermetic bag interlayer can heat to pleura, so that
Pleura reaches suitable temperature, so that the pore of chest skin is opened, it is easier to absorb.
Embodiment 2：
A kind of complex polypeptide pleura, including hermetic bag, film paper and film liquid, film liquid is including by weight percentage with the following group
Point：2 parts of milk peptides, 10 parts of pilose antler peptides, 2 parts of collagen peptides, 2 parts of propane diols, 5 parts of hyaluronic acids, 0.1 part of lavender essential oil, 3 parts of pellets
Join powder extracts and 5 parts of tea oil, film liquid also includes the xanthans that regulation viscosity is 400mpas；Wherein milk peptide, pilose antler peptide and
In collagen peptide, the content of oligopeptides is more than 85%.
The method for preparing the complex polypeptide pleura, comprises the following steps：
1) the 20g propane diols, 50g hyaluronic acids, 50g tea oil of formula ratio is taken to add 100mL water to mix well；
2) liquid material obtained to step 1), while water is added dropwise, while adding 20g milk peptides, 100g pilose antlers peptide, 20g
Collagen peptide, mix well, add water to complement to 1L；
3) in the liquid material obtained to step 2), 1g lavender essential oils and 30g red sage root powder extracts is added, are mixed well；
4) in the liquid material obtained to step 3), it is 420mpas to add xanthans and adjust viscosity；
5) film liquid obtained using step 4) immerses film paper, accelerates dipping using 3 atm malleations, will impregnate complete film
Paper loads spontaneous heat-sealable pouch, sealing.
Embodiment 3
A kind of complex polypeptide pleura, including hermetic bag, film paper and film liquid, film liquid is including by weight percentage with the following group
Point：10 parts of milk peptides, 1 part of pilose antler peptide, 1 part of collagen peptide, 2 parts of glycerine, 5 parts of D-pantothenyl aleohols, 2 parts of lavender essential oils, 5 parts of danshen powders carry
Thing and 2 parts of tea oil are taken, film liquid also includes the xanthans that regulation viscosity is 450mpas；Wherein milk peptide, pilose antler peptide and collagen peptide
In, the content of oligopeptides is more than 85%.
The method for preparing the complex polypeptide pleura, comprises the following steps：
1) the 20g glycerine, 50g D-pantothenyl aleohols, 20g tea oil of formula ratio is taken to add 100mL water to mix well；
2) liquid material obtained to step 1), while water is added dropwise, while adding 100g milk peptides, 10g pilose antlers peptide, 10g
Collagen peptide, mix well, add water to complement to 1L；
3) in the liquid material obtained to step 2), 20g lavender essential oils and 50g red sage root powder extracts is added, are mixed well；
4) in the liquid material obtained to step 3), it is 450mpas to add xanthans and adjust viscosity；
5) film liquid obtained using step 4) immerses film paper, accelerates dipping using 3 atm malleations, will impregnate complete film
Paper loads spontaneous heat-sealable pouch, sealing.
Comparative example 1：
As different from Example 1, preservative is methyl hydroxybenzoate and Nipasol to comparative example 1, and wherein usage amount is oxybenzene
0.05 part of methyl esters, 0.05 part of Nipasol.
Comparative example 2：
Comparative example 2 as different from Example 1, not using milk peptide, pilose antler peptide or collagen peptide, but the collagen egg used
In vain.
Comparative example 3：
As different from Example 1, only with milk peptide, the usage amount of milk peptide is 15 parts to comparative example 3.
Effect assessment and performance detection
1st, determination oxidative
By 10 μm of ol/L Trolox storing solutions phosphorate phthalate buffer be diluted to concentration for 0.05,0.10,0.20,
0.40th, 0.80,1.6 μm of ol/L standard liquid, using phosphate buffer as negative control, sat using fluorescence half-life to be vertical
Mark, using Trolox concentration as abscissa, draw standard curve.
1g embodiment 1-3 complex polypeptide pleura and comparative example 1-3 compound pleura are taken, using distilled water as blank pair
According to, add 100mL phosphate buffer to be diluted, then be respectively adopted phosphate buffer dilution by 10 times, 100 times, 1000
Again, 10000 times, 100000 times of dilutions, dilution are measured, its result is as shown in the table：
The oxidation resistance test result of table 1
As seen from the above table, complex polypeptide pleura provided by the invention can effectively improve the oxidation resistance of skin surface, add
The metabolic activities of strong cell.
2nd, mouse test
SPF female mice of the body weight for 18-22g is used, every group 10, the hair of mouse belly is rejected, will be implemented respectively
Example 1-3 and comparative example 1-3 pleura, which is attached at, picks hair-fields domain, is thrown off after attaching 15min, cleans, mouse is placed in relatively wet
It is 25-30 DEG C to spend for 30-35%, temperature, and ultraviolet light irradiation light intensity is to be handled 2 hours in 800-1000Lx environment, then will be real
The pleura for applying a 1-3 and comparative example 1-3 is attached at and picks hair-fields domain 15min, reprocesses 10 times, and distilled water is bedewed with non-woven fabrics
As a control group, the skin appearance in mouse unhairing region and the situation of mouse mammary are observed and tests colourity, to skin elasticity,
Glossiness is scored with 0-10 graduation, statistics chroma difference Δ L, as a result as shown in the table：
The mouse body surface of table 2 strengthens experience experiment
As seen from the above table, using complex polypeptide pleura provided by the invention, the elasticity and gloss of skin can be effectively improved,
Skin surface will not be damaged simultaneously.
Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to the scope of protection of the invention is limited with this,
The change and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed scope.
Claims (10)
1. a kind of complex polypeptide pleura, it is characterised in that including hermetic bag, film paper and film liquid, the film liquid includes by weight hundred
Divide the following components than meter：0.1-10 parts milk peptide, 0.1-10 part pilose antlers peptide, 0.1-10 parts collagen peptide, 5-20 parts NMF,
0.1-2 parts essential oil, 1-3 parts natural extract, 2-5 parts preservative and the water for supplying 100 parts, the film liquid also include regulation viscosity
For 400-450mpas thickener.
2. complex polypeptide pleura as claimed in claim 1, it is characterised in that in milk peptide and the pilose antler peptide and collagen peptide,
The content of oligopeptides is more than 85%.
3. complex polypeptide pleura as claimed in claim 1, it is characterised in that the thickener is Ka Bomu or xanthans.
4. complex polypeptide pleura as claimed in claim 1, it is characterised in that the NMF is glycerine, propane diols, fourth two
It is more than one or both of alcohol, hyaluronic acid and D-pantothenyl aleohol.
5. complex polypeptide pleura as claimed in claim 1, it is characterised in that the natural extract extracts including danshen powder
Thing.
6. complex polypeptide pleura as claimed in claim 1, it is characterised in that the preservative is tea oil.
7. complex polypeptide pleura as claimed in claim 1, it is characterised in that the material of the film paper is non-woven fabrics, described close
It is provided with envelope and meets oxygen spontaneous heating interlayer.
8. complex polypeptide pleura as claimed in claim 1, it is characterised in that the film liquid include by weight percentage with
Lower component：5 parts of milk peptides, 5 parts of pilose antler peptides, 5 parts of collagen peptides, 2 parts of D-pantothenyl aleohols, 10 parts of butanediols, 1 part of lavender essential oil, 2 parts of pellets
Join powder extracts and 3 parts of tea oil, the film liquid also includes the thickener that regulation viscosity is 400-450mpas.
9. a kind of method for preparing the complex polypeptide pleura described in claim any one of 1-8, comprises the following steps：
1) NMF of formula ratio, preservative is taken to add the water of 1-3 times of volume to mix well；
2) liquid material obtained to step 1), while water is added dropwise, while milk peptide, pilose antler peptide, the collagen peptide of formula ratio are added,
Mix well；
3) in the liquid material obtained to step 2), essential oil and natural extract is added, is mixed well；
4) in the liquid material obtained to step 3), it is 400-450mpas to add thickener and adjust viscosity；
5) the film liquid impregnated membranes paper obtained using step 4), is loaded into hermetic bag, seals.
10. method as claimed in claim 9, in step 5), in impregnation steps, using 2-4 atm malleation.
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| CN201710797797.6A CN107510618A (en) | 2017-09-06 | 2017-09-06 | A kind of complex polypeptide pleura and preparation method |
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| CN201710797797.6A CN107510618A (en) | 2017-09-06 | 2017-09-06 | A kind of complex polypeptide pleura and preparation method |
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| CN106109269A (en) * | 2016-06-29 | 2016-11-16 | 李华忠 | Deer oil and the skin care product for beauty and health care of antler polypeptide compatibility, preparation method and application |
| CN107098962A (en) * | 2016-02-23 | 2017-08-29 | 肌活丽学创研所股份有限公司 | Victory peptide, the method and composition of stimulation melanin generation |
| CN107126554A (en) * | 2017-04-27 | 2017-09-05 | 北京市永康年健康科技有限责任公司 | A kind of collagen product and its preparation method and application |
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2017
- 2017-09-06 CN CN201710797797.6A patent/CN107510618A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257597A (en) * | 2014-09-17 | 2015-01-07 | 郑州蓬泽生物科技开发研究院 | Dendrobe beauty fluid and preparation method thereof |
| CN104548190A (en) * | 2015-01-27 | 2015-04-29 | 广西达庆生物科技有限公司 | Medical biological implants dressing and preparation method thereof |
| CN104606668A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Breast enlargement gel containing complex polypeptides and process thereof |
| CN107098962A (en) * | 2016-02-23 | 2017-08-29 | 肌活丽学创研所股份有限公司 | Victory peptide, the method and composition of stimulation melanin generation |
| CN106109269A (en) * | 2016-06-29 | 2016-11-16 | 李华忠 | Deer oil and the skin care product for beauty and health care of antler polypeptide compatibility, preparation method and application |
| CN107126554A (en) * | 2017-04-27 | 2017-09-05 | 北京市永康年健康科技有限责任公司 | A kind of collagen product and its preparation method and application |
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Application publication date: 20171226 |