CN106109269A - Deer oil and the skin care product for beauty and health care of antler polypeptide compatibility, preparation method and application - Google Patents
Deer oil and the skin care product for beauty and health care of antler polypeptide compatibility, preparation method and application Download PDFInfo
- Publication number
- CN106109269A CN106109269A CN201610487869.2A CN201610487869A CN106109269A CN 106109269 A CN106109269 A CN 106109269A CN 201610487869 A CN201610487869 A CN 201610487869A CN 106109269 A CN106109269 A CN 106109269A
- Authority
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- China
- Prior art keywords
- beauty
- health care
- antler polypeptide
- care product
- skin
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- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 82
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 81
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 81
- 210000003056 antler Anatomy 0.000 title claims abstract description 79
- 230000036541 health Effects 0.000 title claims abstract description 65
- 230000003796 beauty Effects 0.000 title claims abstract description 64
- 241000282994 Cervidae Species 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000011550 stock solution Substances 0.000 claims abstract description 27
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003102 growth factor Substances 0.000 claims abstract description 17
- 239000003381 stabilizer Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 14
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 13
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- 229930003427 Vitamin E Natural products 0.000 claims abstract description 12
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000008213 purified water Substances 0.000 claims abstract description 12
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- 229940046009 vitamin E Drugs 0.000 claims abstract description 12
- 239000011709 vitamin E Substances 0.000 claims abstract description 12
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 11
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 11
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940057910 shea butter Drugs 0.000 claims abstract description 11
- 229940008099 dimethicone Drugs 0.000 claims abstract description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 10
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 8
- 229960000458 allantoin Drugs 0.000 claims abstract description 8
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 238000000746 purification Methods 0.000 claims abstract description 3
- 210000003491 skin Anatomy 0.000 claims description 75
- 239000000463 material Substances 0.000 claims description 39
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 28
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 18
- 239000012071 phase Substances 0.000 claims description 14
- 239000008346 aqueous phase Substances 0.000 claims description 12
- 229960000735 docosanol Drugs 0.000 claims description 9
- 210000002615 epidermis Anatomy 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 229940075495 isopropyl palmitate Drugs 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims 1
- 210000001643 allantois Anatomy 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 49
- 230000010261 cell growth Effects 0.000 abstract description 13
- 235000015097 nutrients Nutrition 0.000 abstract description 5
- 239000013589 supplement Substances 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 41
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 22
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- 102400001368 Epidermal growth factor Human genes 0.000 description 4
- 101800003838 Epidermal growth factor Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
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- DIBAKBGYJUCGDL-UHFFFAOYSA-N 2,6-diamino-n-[1-[(2-amino-2-oxoethyl)amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCCC(N)C(=O)NC(C(=O)NCC(N)=O)CC1=CN=CN1 DIBAKBGYJUCGDL-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 108010026970 bursopoietin Proteins 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
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- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- KXWMDLSCXJUYDA-UHFFFAOYSA-N C(CC)(=O)OC(C)C.C(CCCCCCCCCCCCCCC)(=O)O Chemical compound C(CC)(=O)OC(C)C.C(CCCCCCCCCCCCCCC)(=O)O KXWMDLSCXJUYDA-UHFFFAOYSA-N 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- IJMWOMHMDSDKGK-UHFFFAOYSA-N Isopropyl propionate Chemical compound CCC(=O)OC(C)C IJMWOMHMDSDKGK-UHFFFAOYSA-N 0.000 description 1
- 108010025020 Nerve Growth Factor Proteins 0.000 description 1
- 102000015336 Nerve Growth Factor Human genes 0.000 description 1
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- 235000001014 amino acid Nutrition 0.000 description 1
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- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
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- JZZIHCLFHIXETF-UHFFFAOYSA-N dimethylsilicon Chemical compound C[Si]C JZZIHCLFHIXETF-UHFFFAOYSA-N 0.000 description 1
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- 239000002398 materia medica Substances 0.000 description 1
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- 229940053128 nerve growth factor Drugs 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
Disclosing a kind of deer oil and the skin care product for beauty and health care of antler polypeptide compatibility, preparation method and application, wherein the raw material composition of skin care product for beauty and health care is as follows: by percentage to the quality, purified water 51.2% 35%；Deer oil 7% 18%；Antler polypeptide stock solution 3.8% 15%；Stabilizer 7% 15%；Glycerol 5% 10%；Propylene glycol 5% 8%；Shea butter 3% 5%；Squalane 3% 5%；Isopropyl palmitate 1.5% 5%；Dimethicone 1% 5%；Azone 1% 2%；Lanoline 0.5% 1.5%；Methyl hydroxybenzoate 0.2% 1%；Vitamin E 0.2% 1%；Allantoin 0.2% 1%；Germall B0.2% 1%；Essence 0.1% 1%；Wherein, antler polypeptide stock solution is the purification of aqueous solutions containing antler polypeptide, and the content of epithelical cell growth factor contained in antler polypeptide stock solution is 4.0mg/L.According to the skin care product for beauty and health care of the present invention, good stability, percutaneous absorbability are high, can quickly supplement the nutrients and moisture for skin, promote fairness and the brightness of skin, can be widely used in beauty treatment, health care and/or skin protection.
Description
Technical field
The present invention relates to a kind of cosmetic technical field, particularly relate to the aesthetic health care skin protection of deer oil and antler polypeptide compatibility
Product and its preparation method and application.
Background technology
Hereinafter the background of related of the present invention is illustrated, but these explanations might not constitute the existing of the present invention
Technology.
Antler polypeptide includes abundant epithelical cell growth factor (Epidermal Growth Factor, EGF) and pancreas
Island element like growth factor, nerve growth factor, transforming growth factor etc..Have it is demonstrated experimentally that these somatomedin can speed up table
The division of chrotoplast and growth, the regeneration to skin plays an important role with reparation.But, the half of these cell growth factor
Phase of declining is short, poor stability；It is poor to there is room temperature stability inferior in the multiple somatomedin such as EGF, to hot light extremely unstable, degradable and easy
The shortcomings such as inactivation.Additionally, the highest problem being also its commercialization and needing to solve of cell growth factor percutaneous absorbability.
Therefore, prior art is in the urgent need to the high skin care product for beauty and health care of exploitation good stability, percutaneous absorbability and system thereof
Preparation Method.
Summary of the invention
In order to solve the problem that in prior art, antler polypeptide exists, the invention provides deer oil and antler polypeptide compatibility
Skin care product for beauty and health care and preparation method thereof.
The skin care product for beauty and health care of a kind of deer oil and antler polypeptide compatibility, described U.S. are provided according to an aspect of the present invention
The raw material composition holding health-care skin-protecting products is as follows:
By percentage to the quality, purified water 51.2%-35%；Deer oil 7%-18%；Antler polypeptide stock solution 3.8%-15%；
Stabilizer 7%-15%；Glycerol 5%-10%；Propylene glycol 5%-8%；Shea butter 3%-5%；Squalane 3%-5%；Petiolus Trachycarpi
Isopropyl propionate 1.5%-5%；Dimethicone 1%-5%；Azone 1%-2%；Lanoline 0.5%-1.5%；Methyl hydroxybenzoate
0.2%-1%；Vitamin E 0.2%-1%；Allantoin 0.2%-1%；Germall B 0.2%-1%；Essence 0.1%-1%；
Wherein, antler polypeptide stock solution is the purification of aqueous solutions containing antler polypeptide, table contained in antler polypeptide stock solution
The content of skin cell growth factor is 4.0mg/L.
Also provide for the preparation method of described skin care product for beauty and health care according to a further aspect in the invention, comprise the steps:
(1) purified water, glycerol, propylene glycol and methyl hydroxybenzoate are mixed and heated to 90 DEG C, after being incubated 30 minutes, add
Allantoin, obtains aqueous phase material after dissolving；
(2) by deer oil, stabilizer, lanoline, shea butter, squalane, isopropyl palmitate, dimethicone, dimension life
Element E and azone are mixed and heated to 90 DEG C, after being incubated 30 minutes, add vitamin E, obtain oil phase material；
(3) aqueous phase material is mixed with oil phase material, homogenizing, add essence and germall when stirring is cooled to 40 DEG C-50 DEG C
B, obtains mixed liquor A；
(4) below 37 DEG C, in mixed liquor A, described antler polypeptide stock solution is added, then through high pressure low temperature homogenizing 30 points
Clock；
(6) it is cooled to discharging when about 35 DEG C, ageing, obtains described skin care product for beauty and health care.
A third aspect of the present invention also provides for the skin care product for beauty and health care of first aspect present invention or by the present invention second
The skin care product for beauty and health care that aspect prepares application in beauty treatment, health care and/or skin protection.
According to the skin care product for beauty and health care of the present invention, good stability, percutaneous absorbability are high, can quickly supplement the nutrients for skin
And moisture, promote fairness and the brightness of skin, beauty treatment, health care and/or skin protection can be widely used in.
Detailed description of the invention
Below the illustrative embodiments of the present invention is described in detail.Description to illustrative embodiments is only
For illustration purposes, it is definitely not the present invention and application thereof or the restriction of usage.
Deer oil is identical with antler polypeptide source, has natural homology, prepares with antler polypeptide compatibility using deer oil
During skin care product for beauty and health care, stability and the percutaneous absorbability of various cell growth factor in antler polypeptide can be improved.
Somatomedin in antler polypeptide is many presented in protein, even if these somatomedin deactivations are still
Presented in protein, therefore should not be using protein content as the index weighing antler polypeptide stability.Antler polypeptide
Include abundant epidermal growth factor EGF, EGF and there is the various kinds of cell such as stimulation epidermis cell, endotheliocyte, fibroblast
The character of propagation, can be used for treatment or prevention of various diseases, as promote ulcer, burn and scald injure the wound surfaces such as operation healing,
There is certain treatment and prevention effect (to see China specially to diseases such as chronic atrophic gastritis, oral erosion and ischemia injurys
Profit CN1075874A, CN1111505A, CN1290172A, CN1407899A etc.).Add additionally, EGF has been widely used as cosmetics
Add agent and apply, promote epidermal cell proliferation, improve skin appearance situation.The present invention is with the attenuation of epidermal growth factor EGF
Stability as index study antler polypeptide.
First aspect present invention provides the skin care product for beauty and health care of a kind of deer oil and antler polypeptide compatibility, and its raw material forms
As follows:
By percentage to the quality, purified water 51.2%-35%；Deer oil；Antler polypeptide stock solution；Stabilizer；Glycerol 5%-
10%, such as 5%, 8%, 10%；Propylene glycol 5%-8%, such as 5%, 5.8%, 6.6%, 7.2%, 8%；Shea butter
3%-5%, such as 3%, 3.5%, 4%, 4.5%, 5%；Squalane 3%-5%, such as 3%, 3.5%, 4%, 4.5%,
5%；Isopropyl palmitate 1.5%-5%, such as 1.5%, 2%, 3%, 4%, 5%；Dimethicone 1%-5%, such as
1%, 2%, 3%, 4%, 5%；Azone 1%-2%, such as 1%, 1.25%, 1.5%, 1..75%, 2%；Lanoline 0.5%-
1.5%, such as 0.5%, 0.75%, 1%, 1.25%, 1.5%；Methyl hydroxybenzoate 0.2%-1%, such as 0.2%, 0.4%,
0.6%, 0.8%, 1%；Vitamin E 0.2%-1%, such as 0.2%, 0.4%, 0.6%, 0.8%, 1%；Allantoin
0.2%-1%, such as 0.2%, 0.4%, 0.6%, 0.8%, 1%；Germall B 0.2%-1%, such as 0.2%, 0.4%,
0.6%, 0.8%, 1%；Essence 0.1%-1%.
First antler polypeptide is configured to antler polypeptide stock solution, prepares for raw material with prepared antler polypeptide stock solution the most again
Cosmetics.Specifically, antler polypeptide lyophilized powder is dissolved in purified water prepares antler polypeptide stock solution, wherein epidermal growth factor
The content of sub-EGF is 4.0mg/L.In the material system of the present invention, if the content of antler polypeptide stock solution is too low, antler polypeptide
Less stable, the easy deactivation of epithelical cell growth factor EGF during long-term preservation, it is not easy to extend prepare and improves looks
The shelf-life of health-care skin-protecting products；If the too high levels of antler polypeptide stock solution, antler polypeptide stock solution and the ratio of deer oil in material system
Example is inharmonious so that the metabolism environment of material system and live body deer self differs relatively big, is unfavorable for equally extending preparing to improve looks and protects
The shelf-life of strong skin care item.By percentage to the quality, the content of antler polypeptide stock solution is 3.8%-15% to the present invention, such as
3.8%, 6%, 9%, 12%, 15%.
Typically with antler polypeptide as raw material in prior art, prepare cosmetics in conjunction with other raw materials such as stabilizer, preservative,
But the metabolism environment of the material system of these cosmetics and live body deer self differs farther out, causes the stability of antler polypeptide relatively
Difference.The present invention uses deer oil and antler polypeptide compatibility, and on the one hand deer oil penetration is very strong, quickly can be absorbed by skin, through blood
Liquid is transmitted to subcutaneous tissue, effectively facilitates blood circulation, accelerates metabolism, improves the beauty treatment guarantor preparing skin care product for beauty and health care
Strong effect；On the other hand, containing abundant fatty acid in deer oil, with antler polypeptide, there is excellent bio-compatibility, closest
The own metabolism environment of live body deer, is conducive to improving the stability of antler polypeptide, extends and prepare guaranteeing the quality of skin care product for beauty and health care
Phase.If deer oil too high levels, the cost of preparation skin care product for beauty and health care can be increased, and it is more oily to prepare skin care product for beauty and health care
Greasy, poor user experience；If deer oil content is too low, it is unfavorable for improving the Transdermal absorption of various nutritional labelings in skin care product for beauty and health care
Rate, reduces aesthetic health care effect.By percentage to the quality, the content of deer oil is 7%-18% to the present invention, such as 7%, 9%,
13%, 15%, 18%.
Based on deer oil and antler polypeptide from the point of view of the effect to skin, the two has close function similar in other words, meets
Making mutually in Chinese materia medica, the feature of mutual reinforcement between, this is the objective condition that proposes of the present invention and theoretical foundation.The present inventor is through long-term
Research finds, uses deer oil and antler polypeptide compatibility can significantly improve the stability of antler polypeptide, makes antler polypeptide be difficult to fall
Solve inactivation, deer oil and antler polypeptide can mutual reinforcement between make mutually, Synergistic, the stability of prepared skin care product for beauty and health care and effect
Persistency is more preferable, much larger than the effect sum of deer oil and antler polypeptide.In the material system of skin care product for beauty and health care, work as deer oil
It is: during 1.5-2.5:1 that the synergism of the two is optimum with the mass ratio of antler polypeptide stock solution.
Skin care product for beauty and health care comprises plurality of raw materials and nutritional labeling, in order to improve the stability of various nutritional labeling,
Make it to go bad, mildew, aoxidize, inactivate, decompose, split-phase, it is necessary in material system, add stabilizer, such as 16
Alcohol, octadecanol, eicosanol, docosanol etc..In the present invention, stabilizer mass percent in material system is 7%-15%,
Such as 7%, 9%, 11%, 13%, 15%.If the addition of stabilizer is excessive, the skin care product for beauty and health care mistake prepared can be caused
In sticky, reduce the ionized water content in skin care product for beauty and health care so that it is the replenishing water and preserving moisture effect of skin is reduced；Too low from
Sub-water content also affects skin to the absorption of bioactive substance in skin care product for beauty and health care, reduction aesthetic health care effect.If it is steady
The addition determining agent is too small, and the emulsifying toughness of skin care product for beauty and health care is too low, is easily caused skin care product for beauty and health care split-phase, fall
The stability of the duration of action of low skin care product for beauty and health care and wherein bioactive substance so that it is aoxidize, decompose, inactivation etc..
Additionally, the stabilizer used in cosmetics typically has fragrance, its addition to the fragrance of prepared skin care product for beauty and health care and
The addition of essence has impact, in order to make the skin care product for beauty and health care prepared have specific fragrance, it is necessary to control stable
The addition of agent.In the material system of the present invention in material system, the addition of essence is respectively 7%-15%, 0.1%-
1%, such as 0.2%, 0.4%, 0.6%, 0.8%, 1%.
Octadecanol is also octadecanol, refers to the Organic Alcohol containing 18 carbon atoms.Octadecanol is white, does not dissolves in
Water, has fragrance, is frequently used for the emulsion stabilizer of cosmetics, and appropriate octadecanol can reduce adding of essence in material system
Dosage.Docosanol refers to the Organic Alcohol containing 22 carbon atoms, and white is water insoluble, is frequently used for the viscosity of cosmetics
Stabilizer, it is possible to the regulation viscosity of cosmetics, skin care, hydrotropy bioactive substance.The present invention of the present invention grinds for a long time
Study carefully middle discovery, use octadecanol and docosanol as stabilizer to the emulsion stability of skin care product for beauty and health care and effect simultaneously
Persistent effect is best, wherein, by percentage to the quality, and octadecanol 2%-5%；Docosanol 5%-10%.
In order to improve the transdermal absorption factor of prepared skin care product for beauty and health care, the present invention adds appropriate angle in material system
Shark alkane.Squalane is closest to a kind of lipid of human sebaceous, and affinity is strong, it is possible to accelerate other active component in material system
Permeate in skin, and without greasy feeling.Preferably, by percentage to the quality, the addition of squalane is 3%-5%, such as
3%, 3.5%, 4%, 4.5%, 5%.
In a preferred embodiment, the raw material composition of skin care product for beauty and health care is as follows:
By percentage to the quality, purified water 48.8%；Deer oil 10%；Antler polypeptide stock solution 4.8%；Docosanol 8%；Sweet
Oil 6%；Propylene glycol 5%；Octadecanol 4%；Shea butter 4%；Squalane 3.2%；Isopropyl palmitate 1.5%；Dimethyl-silicon
Oil 1%；Azone 1%；Lanoline 1%；Methyl hydroxybenzoate 0.2%；Vitamin E 0.7%；Allantoin 0.2%；Germall B 0.5%；
Essence 0.1%.
Present invention also offers the preparation method of above-mentioned skin care product for beauty and health care, comprise the steps:
(1) purified water, glycerol, propylene glycol and methyl hydroxybenzoate are mixed and heated to 90 DEG C, after being incubated 30 minutes, add urine
Bursin, obtains aqueous phase material after dissolving；
(2) by deer oil, stabilizer, lanoline, shea butter, squalane, isopropyl palmitate, dimethicone, dimension life
Element E and azone are mixed and heated to 90 DEG C, after being incubated 30 minutes, add vitamin E, obtain oil phase material；
(3) aqueous phase material is mixed with oil phase material, homogenizing, add essence and germall when stirring is cooled to 40 DEG C-50 DEG C
B, obtains mixed liquor A；
(4) below 37 DEG C, in mixed liquor A, described antler polypeptide stock solution is added, then through high pressure low temperature homogenizing 30 points
Clock；
(6) it is cooled to discharging when about 35 DEG C, ageing, obtains described skin care product for beauty and health care.
Skin care product for beauty and health care is directly and skin contact, in order to prevent the more impurity that wherein adulterates, the most permissible after step (1)
Farther include: aqueous phase material is taken out material and filters, remove the impurity in aqueous phase material.The temperature and pressure of sucking filtration can root
Being determined according to practical situation, this is not especially limited by the present invention.
In material system, the granule of raw material can not be too big, otherwise affects the skin absorption on wherein affecting material；Granule is relatively
Big also can generation the stability of prepared skin care product for beauty and health care affects, and easily produces split-phase.In the preferred embodiments of the present invention
In, the homogenizing time in step (3) is 15min.Homogenizing time is too short, is easily caused feed particles relatively big, is unfavorable for that beauty treatment is protected
Stable and wherein nutrient substance the absorption of strong skin care item；Homogenizing time is long, is easily destroyed the structure of wherein nutrient substance,
Affect the aesthetic health care effect of skin care product for beauty and health care.
In order to remove the solid impurity in material system as far as possible, may further include before step (4): the most right
Antler polypeptide stock solution carries out hyperfiltration treatment.Due to the bioactive substance in antler polypeptide and other amino in material system
Acid and vitamin are to light and heat-sensitive, and therefore hyperfiltration treatment should be maintained at less than 37 DEG C as far as possible.
A third aspect of the present invention also provides for the skin care product for beauty and health care of first aspect present invention or by the present invention second
The skin care product for beauty and health care that aspect prepares application in beauty treatment, health care and/or skin protection.For in terms of functional effect, this
Bright can apply to whitening, moisturizing, crease-resistant, speckle dispelling, sun-proof etc., in terms of product form for, the present invention may be used for preparation
Various facial creams, facial film, emulsion, lotion, skin lotion etc..
Below in conjunction with embodiment, the invention will be further described.These embodiments are simply with regard to the side of being preferable to carry out of the present invention
Formula is illustrated, and protection scope of the present invention is not read as pertaining only to these embodiments.
Embodiment 1-16
Raw material forms: by percentage to the quality, glycerol 6%；Propylene glycol 5%；Shea butter 4%；Squalane 3.2%；Palm fibre
Palmitic acid isopropyl propionate 1.5%；Dimethicone 1%；Azone 1%；Lanoline 1%；Methyl hydroxybenzoate 0.2%；Vitamin E 0.7%；
Allantoin 0.2%；Germall B 0.5%；Essence 0.1%；Purified water: surplus；Other raw materials are according to the raw material described in table 1 and use thereof
Amount.Preparation process is as follows:
(1) purified water, glycerol, propylene glycol and methyl hydroxybenzoate are mixed and heated to 90 DEG C, after being incubated 30 minutes, add urine
Bursin, takes out material and filters, obtain aqueous phase material after dissolving；
(2) by deer oil, stabilizer, lanoline, shea butter, squalane, isopropyl palmitate, dimethicone, dimension life
Element E and azone are mixed and heated to 90 DEG C, after being incubated 30 minutes, add vitamin E, obtain oil phase material；
(3) aqueous phase material is mixed with oil phase material, homogenizing 15min, add when stirring is cooled to 40 DEG C-50 DEG C essence and
Germall B, obtains mixed liquor A；
(4) mixed liquor A is carried out hyperfiltration treatment, below 37 DEG C, be then added thereto to antler polypeptide stock solution, through high pressure
Low temperature homogenizing 30 minutes；
(6) it is cooled to discharging when about 35 DEG C, ageing, obtains described skin care product for beauty and health care, the beauty treatment of the present invention is protected
Strong skin care item are prepared as facial film.
Different embodiments prepare the mensuration of antler polypeptide stability in facial film:
The NaCl solution breakdown of emulsion extracting antler polypeptide using mass fraction to be 5%, then utilizes MTT Determination Staining facial film
The content c of mesocuticle cell growth factor EGF0And the content c of epithelical cell growth factor EGF after 12 months12, thin with epidermis
The attenuation of intracellular growth factor EGF is as the index of measurement antler polypeptide stability, and attenuation is the least, shows that antler polypeptide is the most steady
Fixed.Wherein, according to the attenuation of equation below computational chart skin cell growth factor EGF, result is listed in the table below in 1:
EGF attenuation=(c0-c12)/c0× 100%.
Table 1 embodiment and experimental result
Note: in upper table, the storage temperature of skin care product for beauty and health care is 4 DEG C.
From the experimental result of embodiment 1 and 2 it can be seen that to use deer oil and antler polypeptide compatibility can significantly reduce epidermis thin
The attenuation of intracellular growth factor EGF, extends the shelf-life of facial film.The facial film that above-described embodiment is also prepared by the present invention is felt
Official tests, and from the point of view of the experience feedback result of volunteer, compared with simple employing deer oil or antler polypeptide, uses deer oil and Cornu Cervi Pantotrichum
The sensory evaluation of facial film prepared by polypeptide compatibility is preferable, high resilience the most tight by rear skin wet, non-greasy.
From the experimental result of embodiment 2-5 it can be seen that the addition of deer oil is too high or too low all can improve epidermis cell
The attenuation of somatomedin EGF, affects the shelf-life of facial film.From the experimental result of embodiment 6-10 it can be seen that antler polypeptide
Addition be not easy to too high or too low, the most also can improve the attenuation of epithelical cell growth factor EGF.
From embodiment 11-16 it can be seen that use octadecanol or docosanol as compared with stabilizer with simple, use
Octadecanol and docosanol compatibility can significantly reduce the attenuation of epithelical cell growth factor EGF.Additionally, octadecanol and 22
The addition of alcohol also has certain impact to EGF decrement, and too low or too high being all unfavorable for extends guaranteeing the quality of skin care product for beauty and health care
Phase.
The mensuration of antler polypeptide stability under condition of different temperatures in facial film:
The facial film prepared using embodiment 1 as a control group, the facial film for preparing of embodiment 3 as experimental group, measure it respectively
In epithelical cell growth factor EGF preserve 6 months and 12 months under three kinds of condition of different temperatures after attenuation, result is such as
Shown in table 2 below.Three kinds of temperature conditionss are respectively as follows: 4 DEG C；25℃；4 DEG C, 25 DEG C of cycle alternations, wherein 4 DEG C preserve 1h, 25 DEG C of preservations
23h。
Antler polypeptide stability under condition of different temperatures studied by table 2
From table 2 it can be seen that after preserving 6 months, matched group EGF attenuation under three kinds of temperature conditionss is 80% left side
Right；And the EGF attenuation of experimental group is less than 15%, far below matched group, it is seen that antler polypeptide in the facial film that the present invention prepares
Stability is more preferable, acts on more longlasting.After matched group preserves 12 months under three kinds of temperature conditionss, EGF attenuation is close
100%, antler polypeptide substantially completely inactivates；And EGF attenuation is less than 30% in experimental group, the stability of antler polypeptide is obvious
Higher than matched group, the stability using deer oil and antler polypeptide compatibility can significantly improve antler polypeptide is described.At the present embodiment
Under three kinds of temperature conditionss, during 4 DEG C of preservations, EGF attenuation is minimum, and the stability of antler polypeptide is best.
Compared with prior art, the present invention uses deer oil and antler polypeptide compatibility to prepare skin care product for beauty and health care, and Cornu Cervi Pantotrichum is many
Peptide is identical with deer oil source, has natural homology, bio-compatibility good, the two composition and have the most again close it
Place, so formula compatibility mutual reinforcement between, making mutually, Synergistic, scientific and reasonable, effect ratio is used alone the most notable, improves Cornu Cervi Pantotrichum
The stability of polypeptide and the persistency of product effect.Additionally, antler polypeptide comprised various somatomedin, various in deer oil
The useful nutrient of aminoacid ingredient and vitamin can keep its biological activity, as far as possible at cell under natural physiological environment
Between deeper broadly spread apart, quickly for skin extra-nutrition；Those moisture that cannot evaporate of skin surface then can be deposited in table
Cortex, the moisture of epidermal area is full, skin seem will smoother tight, microgroove also can become light, simultaneously white
Fair-skinned degree, brightness are obviously improved.
Although with reference to illustrative embodiments, invention has been described, but it is to be understood that the present invention does not limit to
The detailed description of the invention that Yu Wenzhong describes in detail and illustrates, in the case of without departing from claims limited range, this
Described illustrative embodiments can be made various change by skilled person.
Claims (10)
1. a deer oil and the skin care product for beauty and health care of antler polypeptide compatibility, it is characterised in that described skin care product for beauty and health care
Raw material composition is as follows:
By percentage to the quality, purified water 51.2%-35%；Deer oil 7%-18%；Antler polypeptide stock solution 3.8%-15%；Stable
Agent 7%-15%；Glycerol 5%-10%；Propylene glycol 5%-8%；Shea butter 3%-5%；Squalane 3%-5%；Palmic acid is different
Propyl ester 1.5%-5%；Dimethicone 1%-5%；Azone 1%-2%；Lanoline 0.5%-1.5%；Methyl hydroxybenzoate 0.2%-
1%；Vitamin E 0.2%-1%；Allantoin 0.2%-1%；Germall B 0.2%-1%；Essence 0.1%-1%；
Wherein, antler polypeptide stock solution is the purification of aqueous solutions containing antler polypeptide, and epidermis contained in antler polypeptide stock solution is thin
The content of the intracellular growth factor is 4.0mg/L.
2. skin care product for beauty and health care as claimed in claim 1, wherein, deer oil is 1.5-with the mass ratio of antler polypeptide stock solution
2.5:1。
3. skin care product for beauty and health care as claimed in claim 1 or 2, wherein, described stabilizer includes octadecanol and docosanol.
4. skin care product for beauty and health care as claimed in claim 3, wherein, by percentage to the quality, octadecanol 2%-5%；20
Glycol 5%-10%.
5. skin care product for beauty and health care as claimed in claim 3, wherein, the raw material composition of described skin care product for beauty and health care is as follows:
By percentage to the quality, purified water 48.8%；Deer oil 10%；Antler polypeptide stock solution 4.8%；Docosanol 8%；Glycerol
6%；Propylene glycol 5%；Octadecanol 4%；Shea butter 4%；Squalane 3.2%；Isopropyl palmitate 1.5%；Dimethicone
1%；Azone 1%；Lanoline 1%；Methyl hydroxybenzoate 0.2%；Vitamin E 0.7%；Allantoin 0.2%；Germall B 0.5%；Fragrant
Essence 0.1%.
6. the preparation method of the skin care product for beauty and health care as described in claim 1-5 is arbitrary, it is characterised in that comprise the steps:
(1) purified water, glycerol, propylene glycol and methyl hydroxybenzoate are mixed and heated to 90 DEG C, after being incubated 30 minutes, add allantois
Element, obtains aqueous phase material after dissolving；
(2) by deer oil, stabilizer, lanoline, shea butter, squalane, isopropyl palmitate, dimethicone, vitamin E and
Azone is mixed and heated to 90 DEG C, after being incubated 30 minutes, adds vitamin E, obtains oil phase material；
(3) aqueous phase material is mixed with oil phase material, homogenizing, add essence and germall B when stirring is cooled to 40 DEG C-50 DEG C,
To mixed liquor A；
(4) below 37 DEG C, in mixed liquor A, described antler polypeptide stock solution is added, then through high pressure low temperature homogenizing 30 minutes；
(6) it is cooled to discharging when about 35 DEG C, ageing, obtains described skin care product for beauty and health care.
7. preparation method as claimed in claim 6, farther includes after step (1): aqueous phase material is taken out material and filters,
Remove the solid impurity in aqueous phase material.
8. preparation method as claimed in claim 7, the homogenizing time in step (3) is 15min.
9. preparation method as claimed in claim 7, farther includes before step (4): before use to institute below 37 DEG C
State antler polypeptide stock solution and carry out hyperfiltration treatment.
10. skin care product for beauty and health care as described in claim 1-5 is arbitrary or claim 6-9 arbitrary as described in preparation method system
The skin care product for beauty and health care obtained application in beauty treatment, health care and/or skin protection.
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Cited By (2)
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| CN107510618A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide pleura and preparation method |
| CN111358715A (en) * | 2019-04-18 | 2020-07-03 | 吉林省东鳌鹿业科技开发有限公司 | Deer collagen polypeptide repair eye cream and preparation method thereof |
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| CN105250173A (en) * | 2015-10-16 | 2016-01-20 | 刘爱红 | Skin-whitening and skin-tendering skin care product |
| CN105287320A (en) * | 2015-12-08 | 2016-02-03 | 广州市花安堂生物科技有限公司 | Mild lifting and repairing eye cream and preparation method thereof |
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Patent Citations (4)
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| CN102266280A (en) * | 2011-07-25 | 2011-12-07 | 吉林农业大学 | Application of refined deer oil to preparation of moisture preserving cosmetics |
| CN103110534A (en) * | 2013-01-29 | 2013-05-22 | 海南巨鹿堂保健美容品有限公司 | Combined essence of composite velvet antler polypeptide lyophilized powder and nano-scale buffering microemulsion for skin beauty and health care and preparation method of combined essence |
| CN105250173A (en) * | 2015-10-16 | 2016-01-20 | 刘爱红 | Skin-whitening and skin-tendering skin care product |
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| CN107510618A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide pleura and preparation method |
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