CN105106217B - A kind of maternal nutritional replenishers and preparation method thereof - Google Patents
A kind of maternal nutritional replenishers and preparation method thereof Download PDFInfo
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- CN105106217B CN105106217B CN201510496987.5A CN201510496987A CN105106217B CN 105106217 B CN105106217 B CN 105106217B CN 201510496987 A CN201510496987 A CN 201510496987A CN 105106217 B CN105106217 B CN 105106217B
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- vitamin
- parts
- metafolin
- maternal nutritional
- folic acid
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a kind of maternal nutritional replenishers, including following components：L methopterins or L methopterin salt, the maternal nutritional replenishers further include that following two components are made：Arginine and vitamin B12.The preparation method of above-mentioned maternal nutritional replenishers：All components are uniformly mixed.Beneficial effects of the present invention are：The invention replaces folic acid in maternal nutritional supplement field with L methopterins, avoids the problem of folic acid is unable to sorption enhanced caused by gene defect, and avoid the adverse reaction of the accumulation of folic acid in vivo when being unable to sorption enhanced folic acid.Addition arginine is combined with L methopterins and vitamin B12, is played a protective role to pregnant woman and fetus, and some of pregnant women's and embryo growth and development frequently-occurring diseases is avoided to occur.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of maternal nutritional replenishers and preparation method thereof.
Background technology
Gestation or intended pregnancy women are the special populations for being different from population.They ensure the pregnant institute that secures good health
The all nutrients of need, simultaneously as in view of the presence of foetus, the supplement of nutrient is paid particular attention to safely, soon
It is fast and effective.Wherein one kind most well-known in folic acid maternal nutritional element the most, is valued by people.
But in the metabolism of human body, folic acid, which is transformed into after methopterin, just has physiological function.And some are due to base
The defect of cause cannot complete dependent conversion process in vivo, still, special pass of the pregnant or intended pregnancy women due to constitution
System can not do related gene detection in period of gestation or plan period of gestation, this may cause to supplement folic acid still not
It can get a desired effect.
In addition, the ingredient of maternal nutritional replenishers is single at present, the effect of extra-nutrition is limited, cannot be satisfied people increasingly
The needs to health increased.
Invention content
In order to solve the above problem of the existing technology, the present invention provides a kind of maternal nutritional replenishers and its preparations
Method.The maternal nutritional replenishers replace traditional folic acid using methopterin, improve absorption problem, meanwhile, the pregnant woman
Ingredient in nutritional supplement is various, the significant effect of extra-nutrition.
The technical solution adopted in the present invention is：A kind of maternal nutritional replenishers, including following components：Metafolin or
Metafolin salt, the maternal nutritional replenishers further include that following two components are made：Arginine and vitamin B12.
Preferably, the maternal nutritional replenishers further include following components：Magnesia and vitamin B6.
Preferably, the maternal nutritional replenishers further include following components：Vitamin B1, vitamin B2, vitamin B3, dimension
Raw element C, vitamine D3, vitamin E, calcium carbonate, ferrous sulfate, iodide and soybean lecithin.
Further, the maternal nutritional replenishers include the component of following mass parts：1-2 parts of metafolin or 1-
2 parts of metafolin salt, the maternal nutritional replenishers further include that the component of following mass parts is made：20-600 parts of smart ammonia
Acid and 0.5-1.5 parts of vitamin B12.
Further, the maternal nutritional replenishers include the component of following mass parts：1-2 parts of metafolin or 1-
2 parts of metafolin salt, the maternal nutritional replenishers further include that the component of following mass parts is made：20-600 parts of smart ammonia
Acid, 0.5-1.5 parts of vitamin B12,30-100 parts of magnesia and 5-45 parts of vitamin B6.
Further, the maternal nutritional replenishers include the component of following mass parts：1-2 parts of metafolin or 1-
2 parts of metafolin salt, the maternal nutritional replenishers further include that the component of following mass parts is made：20-600 parts of smart ammonia
Acid, 0.5-1.5 parts of vitamin B12,30-100 parts of magnesia, 5-45 parts of vitamin B6,1-2 parts of vitamin B1,1-2
The vitamin B2 of part, 15-20 parts of vitamin B3,70-100 parts of vitamin C, 1-10 parts of vitamine D3,5-25 parts of dimension
E, 60-160 parts of calcium carbonate of raw element, 5-50 parts of ferrous sulfate, 180-260 parts of iodide and 200-500 parts of soybean ovum
Phosphatide.
Preferably, the metafolin salt is metafolin calcium or metafolin magnesium.As metafolin
Calcium salt and magnesium salts, while supplementing metafolin, also supplement calcium constituent and magnesium elements, in addition, metafolin at
After salt, chemical property is also more stablized.
The preparation method of above-mentioned maternal nutritional replenishers：All components are uniformly mixed.
For beneficial effects of the present invention are explained further, now each component of the present invention is further elaborated：
The existence form of metafolin or metafolin salt in vivo is the same, that is to say, that the two is in nutrition
Play the role of being identical in replenishers, in order to describe conveniently, the present invention is unified to use metafolin when narration acts on
To express.
Metafolin is also known as (6s) -5-methyltetrahydrofolate, is the form that is primarily present of activity in man's folic acid, folic acid
Being transformed into after methopterin just has physiological function.Folic acid will can be just converted by internal physiological metabolism step with biology
Active metafolin, metafolin can be by blood-brain barrier, cross-film conveying, and then plays physiological function.
But during folic acid is converted to metafolin, the ginseng of methylenetetrahydrofolate reductase and MTRR enzymes is needed
With cooperation, methylenetetrahydrofolate reductase and MTRR enzymes are controlled by two genes of mthfr gene and MTRR respectively, and in people
In group, the occupation rate population of missing or the above-mentioned at least one gene of defect is about 18%, and local district occurred frequently is up to 40%
Crowd cannot be effectively converted to bioactivity using folic acid up to 70% in specific crowd (such as depression)
Metafolin, it is significant to note that, in pregnant woman depression crowd about 70%, so, in pregnant woman group, have
Sizable ratio cannot convert folic acid to metafolin, since whether pregnant woman seldom goes the body for understanding them that can
Folic acid is enough absorbed and converts, a big chunk Supplement of folic acid actually in them is invalid, it might therefore and cause them
The shortage of itself and fetus actually metafolin.
And for this specific group of pregnant woman, in gestation, blood circulation is more vigorous, to metafolin
Demand is also apparently higher than common people.So in pregnant woman's often a large amount of Supplement of folic acid in gestation, but when it in vivo cannot
When effective conversion, two serious consequences can be caused：It 1, cannot since folic acid cannot be converted into the metafolin of physiological action
The folic acid residual of conversion can damage pregnant woman and fetus；2, the presence of internal folic acid can cover the table of vitamin B12 deficiency
Existing symptom, that is to say, that when folic acid cannot be by timely sorption enhanced, even if being deficient in vitamin B12 simultaneously in vivo, pregnant woman oneself
Not only itself can not discover, and general chemical examination inspection can not also detect.And lacking folic acid and vitamin B12 all may cause such as
The corresponding illness such as pregnant woman anemia occurs, and if the two all lacks, the incidence probability of corresponding illness will be significantly greatly increased, these pregnant woman
Corresponding illness can greatly harm embryo growth and development.
After furtheing investigate the above-mentioned mechanism of action, inventor is creative directly to be made using metafolin instead of conventional
Folic acid, the present invention can directly supplement the metafolin for having bioactivity needed for body, and which greatly enhances this
The scope of application and effective percentage of invention.
Arginine is the semi-dispensable amino acid of common people, is essential amino acid for fetus, infant, is to safeguard nerve
Bioactive substance necessary to system and blood circulation normal function.Arginine is the direct precursor for synthesizing NO (nitric oxide),
It is the main matter for maintaining and ensureing endothelial cell normal work, can improves, promote blood circulation.Research shows that increasing arginine
Supply not only helps increase NO and generates and protect, improves inner skin cell function；And help to increase the work of NO synzyme
Property.
Arginine is human body semi-dispensable amino acid, and pregnant woman, due to physiological particularity, researches on arginine requirement is more than common people
More, pregnant woman, which has heredity, age and illness factor, can all lead to the shortage of arginine in vivo.Gravid woman is at this time with greater need for benefit
Sufficient enough arginine, not only meet itself needs, since fetus can only obtain arginine from parent, more to meet fetal growth
The needs of development.In addition, supplement arginine Human Umbilical Vein Endothelial Cells shield, pregnant woman's blood vessel elasticity can be kept, promotes blood
Cycle prevents the hypertension of pregnancy and eclampsia breaking-out.
For fetus, arginine is essential amino acid, indispensable enhancing development nutriment.Arginine
Have and promote growth hormone release action, studies have shown that arginine can prevent the too small disease of fetus, promote its increase height, weight,
Intellectual development makes fetus items physical signs reach health standards.From this point of view, it is very necessary in pregnancy period supplement arginine
's.
Vitamin B12 is called cobalamin, is the unique vitamin containing metallic element.In the present invention, the life of vitamin B12
Reason effect mainly has：1, as the co-factor of transmethylase, the synthesis of methionine, thymidine etc. is participated in；2, L- first is protected
The transfer and storage of base folic acid in the cell.
The function of magnesia：Magnesium is the necessary composition of a variety of enzymes, and enzyme in the manufacture of protein, fat metabolism and is lost
It passes duplication of matter DNA etc. and plays very important effect in the process；On the other hand, magnesium or internal help are absorbed and are utilized
Calcareous poising agent can promote absorption of the cell to calcium, while enhance immune system.Currently, domestic, there are unilateral simple
The problem of the extra-nutrition unevenness of " whole people replenish the calcium ", therefore lead to the shortage of calcium uptake auxiliary agent magnesium.Magnesia in the present invention, one
Aspect can with the activity of enzyme in reinforcement, on the other hand may also help in absorb it is calcareous, reach the health indicator of calcium balance.
Vitamin B6 is also known as pyridoxine comprising pyridoxol, pyridoxal and pyridoxamine are deposited in the form of phosphate in vivo
It is being a kind of water soluble vitamin, is meeting light or alkali destructible, non-refractory.Vitamin B6 acts predominantly on the blood of human body, flesh
These positions of meat, nerve, skin；The physiological reaction being primarily involved in has the manufacturing of hydrochloric acid in gastric juice in the synthesis of antibody, digestive system, fat
With protein utilization and maintenance sodium/potassium balance.
Vitamin B1 is also known as thiamine, is white crystal；Vitamin B1 physiological function is to improve a poor appetite, and is maintaining nerve just
Often activity.Vitamin B2 is also known as riboflavin, is slightly soluble in water, and heating is stable in neutral or acid solution.Vitamin B2
Major physiological functions is to promote to be metabolized as coenzyme.Vitamin B3 is also known as niacin, is a kind of water soluble vitamin, promotes Digestive
The health of system mitigates gastrointestinal disorders；Keep skin healthier；Prevent the gentle serious migraine of solution；It promotes blood circulation, makes blood pressure
Decline.
Pregnant women lacks B family vitamin, it may appear that tired, weak, small legs and tachycardia symptom；Also will appear
Matter and energy metabolic disorder, is easy to happen hypoferric anemia, this will all reduce absorption of the parent to nutrition, cause fetus each side
Flour nutrition lacks, and easily influences the development of brain, causes fetus phrenoblabia, easily cries and screams after birth, is uneasy, is irritated, while will also draw
Gastrointestinal peristalsis decrease, constipation, digestive juice secretion reduction, the symptoms such as loss of appetite are played, and accelerate the morning sickness of pregnant woman, are made
Parent is worse to the absorption of nutrition, causes fetus various aspects nutritional deficiency, to severely impact the development of brain, influences fetus the present
Intelligence afterwards, therefore pregnant woman is centainly it is noted that the intake of B family vitamin.
Vitamin C is also known as L-AA, and in human body, vitamin C is high-efficiency antioxidant agent, for mitigating ascorbic acid
The oxidation stress of peroxidase substrate, in addition, participating in making there are many more vitamin C is also required in important biosynthetic process
With.
Vitamine D3 is a kind of liposoluble vitamin, is also regarded as a kind of hormone precursor acting on Ca,P metabolism, dimension
Raw element D3 may participate in the metabolism of calcium and phosphorus, promote its absorption, and play an important role to New bone formation.Vitamin E is a kind of liposoluble
Property vitamin, hydrolysate be tocopherol, be one of most important antioxidant.
Calcium carbonate is a kind of inorganic compound, in the present invention, mainly as calcium constituent replenishers.Ferrous sulfate is a kind of
Inorganic compound, in the present invention, mainly as ferro element replenishers.Iodide in the present invention, are mended mainly as iodine
Fill agent.Soybean lecithin (Lecithin Himgh Potency) is also known as Lecithin High Potency, and soybean lecithin is the group of cell membrane
At part, enhancing cellular informatics transmission capacity improves brain activity, promotes cell membrane self-repairing capability and protects liver, resists outer
Portion encroaches on ability.
Beneficial effects of the present invention are：
1, the invention in maternal nutritional supplement field replaces folic acid with metafolin, and it is scarce to avoid Yin Jiyin
The problem of folic acid caused by falling into is unable to sorption enhanced, and avoid the accumulation of folic acid in vivo when being unable to sorption enhanced folic acid
Adverse reaction.
2, arginine is added in the maternal nutritional replenishers in the present invention, arginine is the half required amino of common people
Acid, but be essential amino acid for fetus, infant, arginine can promote blood circulation, and pregnant women's is made to meet blood
Liquid overactive circulation needs, and effectively meets the needs of the more semi-dispensable amino acids of pregnant woman's period of gestation, while meeting tire
Youngster's essential amino acid needs；Avoid pregnant woman such as anaemia, the hypertension of pregnancy and eclampsia, pregnant depression these pregnant woman's common diseases hair
It is raw；Most importantly two kinds of substances of metafolin and arginine, which combine, has amalgamation good, without physiology side reaction residue
Matter, pregnant woman fetus are free from side effects while obtaining protection and maximum nutritional supplementation benefit.
3, the maternal nutritional replenishers ingredient in the present invention is various, and the nutrition for enumerating pregnant woman substantially in gestational period whole is mended
Agent can reach a kind of tonic, the effect of multi-efficiency.
Specific implementation mode
With reference to specific embodiment, the present invention is further elaborated.
Embodiment 1
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin of 1mg, the arginine of 20mg and
The vitamin B12 of 0.5mg.
Embodiment 2
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin calcium of 2mg, the arginine of 600mg
With the vitamin B12 of 1.5mg.
Embodiment 3
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin magnesium of 1.5mg, the smart ammonia of 310mg
The vitamin B12 of acid and 1mg.
Embodiment 4
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin calcium of 1mg, the arginine of 20mg
With the vitamin B12 of 0.5mg, the vitamin B6 of the magnesia of 30mg and 5mg.
Embodiment 5
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin magnesium of 2mg, the arginine of 600mg
With the vitamin B12 of 1.5mg, the vitamin B6 of the magnesia of 100mg and 45mg.
Embodiment 6
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin of 1.5mg, the arginine of 310mg
With the vitamin B12 of 1mg, the vitamin B6 of the magnesia of 65mg and 25mg.
Embodiment 7
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin magnesium of 1mg, the arginine of 20mg
With the vitamin B12 of 0.5mg, the magnesia of 30mg, the vitamin B6 of 5mg, the vitamin B1 of 1mg, 1mg vitamin B2,
The vitamin B3 of 15mg, the vitamin C of 70mg, the vitamine D3 of 1mg, 5mg parts of vitamin E, the calcium carbonate of 60mg, 5mg
The soybean lecithin of ferrous sulfate, the iodide of 180mg and 200mg.
Embodiment 8
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin of 2mg, the arginine of 600mg and
The vitamin B12 of 1.5mg, the magnesia of 100mg, the vitamin B6 of 45mg, the vitamin B1 of 2mg, 2mg vitamin B2,
The vitamin B3 of 20mg, the vitamin C of 100mg, the vitamine D3 of 10mg, 25mg parts of vitamin E, 160mg calcium carbonate,
The soybean lecithin of the ferrous sulfate of 50mg, the iodide of 260mg and 500mg.
Embodiment 9
A kind of maternal nutritional replenishers, include the component of following quality：The metafolin calcium of 1.5mg, the smart ammonia of 310mg
The vitamin of acid and the vitamin B12 of 1mg, the magnesia of 65mg, the vitamin B6 of 25mg, the vitamin B1 of 1.5mg, 1.5mg
The vitamin B3 of B2,17mg, the vitamin C of 85mg, the vitamine D3 of 5mg, 15mg parts of vitamin E, 110mg calcium carbonate,
The soybean lecithin of the ferrous sulfate of 30mg, the iodide of 220mg and 350mg.
The preparation method of any maternal nutritional replenishers of embodiment 1-9：All components are uniformly mixed.It needs
Illustrate, in above-described embodiment, vitamin B12 is in the form of Mecobalamin；Vitamine D3 is in the form of d- alpha-tocopherols；Vitamin B1
In the form of thiamine mononitrate；Vitamin B3 is in the form of niacinamide；For vitamin B6 in the form of pyridoxime 5-phosphate, above-mentioned form has life
The advantages of object activity is high, good absorption effect.Mecobalamin is a kind of biologically active form of vitamin B12.Methyl-B12 is dimension life
The principal mode of vitamin B12 in the cycle of plain B12, therefore be also to be primarily present form into peripheral tissues.Methyl-B12
It is absorbed by using the specific enteron aisle mechanism such as internal factor and diffusion mode, absorptivity is high
To prove the validity of the maternal nutritional replenishers, following clinical test has been done：
300 pregnant woman are chosen in this experiment, are randomly divided into one group of experiment, test two groups and control group, every group of 100 people, and three
Age, physical condition between group and the bad border no difference of science of statistics of life.
Since the first month that is pregnant, one group of experiment daily maternal nutritional replenishers in embodiment 2 test two groups
The daily maternal nutritional replenishers in embodiment 8, control group daily commercially available folic acid.Three groups are continuously taken to life
Production.Wherein, it tests one group and two groups of experiment is respectively taken once daily morning and evening, be the dosage described in embodiment every time, control
Group is normally taken according to the specification of commercially available folic acid.
3rd month, the 6th month and September periodically carry out biochemical measurement to all pregnant woman, and statistical data see the table below 1.
Table 1：The sick situation contrast table of every group of pregnant woman
It will be obvious from table 1, the pregnant woman of one group of experiment is significantly better than control group, institute in the physiological status of period of gestation
The with obvious effects better than common commercially available folic acid of maternal nutritional replenishers provided by the invention is stated, in addition, the pregnant woman of two groups of experiment exists
The physiological status of period of gestation, which is slightly better than, tests one group, illustrates that the dietary supplement of two groups of experiment is more comprehensive, resultant effect
More preferably.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is every that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (3)
1. a kind of maternal nutritional replenishers, which is characterized in that include the component of following mass parts：1-2 parts of metafolin or
1-2 parts of metafolin salt, the maternal nutritional replenishers further include the component of following mass parts：20-600 parts of smart ammonia
Acid, 0.5-1.5 parts of vitamin B12,30-100 parts of magnesia, 5-45 parts of vitamin B6,1-2 parts of vitamin B1,1-2
The vitamin B2 of part, 15-20 parts of vitamin B3,70-100 parts of vitamin C, 1-10 parts of vitamine D3,5-25 parts of dimension
E, 60-160 parts of calcium carbonate of raw element, 5-50 parts of ferrous sulfate, 180-260 parts of iodide and 200-500 parts of soybean ovum
Phosphatide.
2. maternal nutritional replenishers according to claim 1, which is characterized in that the metafolin salt is L- methyl leaves
Sour calcium or metafolin magnesium.
3. the preparation method of maternal nutritional replenishers described in claim 1, which is characterized in that be uniformly mixed all components i.e.
It can.
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