CN109170904A - A kind of maternal nutritional replenishers and preparation method thereof - Google Patents
A kind of maternal nutritional replenishers and preparation method thereof Download PDFInfo
- Publication number
- CN109170904A CN109170904A CN201811005667.5A CN201811005667A CN109170904A CN 109170904 A CN109170904 A CN 109170904A CN 201811005667 A CN201811005667 A CN 201811005667A CN 109170904 A CN109170904 A CN 109170904A
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- CN
- China
- Prior art keywords
- parts
- vitamin
- soft capsule
- added
- linolenic oil
- Prior art date
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- Pending
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- 235000016709 nutrition Nutrition 0.000 title claims abstract description 31
- 230000008774 maternal effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims description 7
- 239000007901 soft capsule Substances 0.000 claims abstract description 85
- 239000003921 oil Substances 0.000 claims abstract description 69
- 239000000203 mixture Substances 0.000 claims abstract description 42
- 239000002994 raw material Substances 0.000 claims abstract description 39
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000010445 lecithin Nutrition 0.000 claims abstract description 29
- 239000000787 lecithin Substances 0.000 claims abstract description 29
- 229940088594 vitamin Drugs 0.000 claims abstract description 23
- 229930003231 vitamin Natural products 0.000 claims abstract description 23
- 235000013343 vitamin Nutrition 0.000 claims abstract description 23
- 239000011782 vitamin Substances 0.000 claims abstract description 23
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 23
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 22
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 20
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 13
- 229940067606 lecithin Drugs 0.000 claims abstract description 13
- 238000005253 cladding Methods 0.000 claims abstract description 11
- 239000008199 coating composition Substances 0.000 claims abstract description 11
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims abstract description 11
- 239000001230 potassium iodate Substances 0.000 claims abstract description 11
- 235000006666 potassium iodate Nutrition 0.000 claims abstract description 11
- 229940093930 potassium iodate Drugs 0.000 claims abstract description 11
- 229960003080 taurine Drugs 0.000 claims abstract description 11
- 108010011485 Aspartame Proteins 0.000 claims abstract description 10
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 10
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims abstract description 10
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims abstract description 10
- 235000010357 aspartame Nutrition 0.000 claims abstract description 10
- 239000000605 aspartame Substances 0.000 claims abstract description 10
- 229960003438 aspartame Drugs 0.000 claims abstract description 10
- 235000019152 folic acid Nutrition 0.000 claims abstract description 10
- 239000011724 folic acid Substances 0.000 claims abstract description 10
- 229960000304 folic acid Drugs 0.000 claims abstract description 10
- 229940050168 zinc lactate Drugs 0.000 claims abstract description 10
- 235000000193 zinc lactate Nutrition 0.000 claims abstract description 10
- 239000011576 zinc lactate Substances 0.000 claims abstract description 10
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 9
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims abstract description 9
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 9
- 229930003471 Vitamin B2 Natural products 0.000 claims abstract description 9
- 235000002332 ferrous fumarate Nutrition 0.000 claims abstract description 9
- 239000011773 ferrous fumarate Substances 0.000 claims abstract description 9
- 229960000225 ferrous fumarate Drugs 0.000 claims abstract description 9
- 229960002477 riboflavin Drugs 0.000 claims abstract description 9
- 235000019164 vitamin B2 Nutrition 0.000 claims abstract description 9
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 9
- 239000003292 glue Substances 0.000 claims description 59
- 238000003756 stirring Methods 0.000 claims description 47
- 239000002775 capsule Substances 0.000 claims description 38
- 238000001035 drying Methods 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 18
- 229930003316 Vitamin D Natural products 0.000 claims description 16
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 16
- 235000019166 vitamin D Nutrition 0.000 claims description 16
- 239000011710 vitamin D Substances 0.000 claims description 16
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 16
- 229940046008 vitamin d Drugs 0.000 claims description 16
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 12
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 12
- 235000019155 vitamin A Nutrition 0.000 claims description 12
- 239000011719 vitamin A Substances 0.000 claims description 12
- 229940045997 vitamin a Drugs 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229930003427 Vitamin E Natural products 0.000 claims description 11
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 11
- 235000019165 vitamin E Nutrition 0.000 claims description 11
- 229940046009 vitamin E Drugs 0.000 claims description 11
- 239000011709 vitamin E Substances 0.000 claims description 11
- 108010010803 Gelatin Proteins 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 229920000159 gelatin Polymers 0.000 claims description 10
- 239000008273 gelatin Substances 0.000 claims description 10
- 235000019322 gelatine Nutrition 0.000 claims description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims description 10
- 238000005469 granulation Methods 0.000 claims description 10
- 230000003179 granulation Effects 0.000 claims description 10
- 235000010355 mannitol Nutrition 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 239000008188 pellet Substances 0.000 claims description 10
- 230000001376 precipitating effect Effects 0.000 claims description 10
- 239000007779 soft material Substances 0.000 claims description 10
- 239000011122 softwood Substances 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000002002 slurry Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 239000007916 tablet composition Substances 0.000 claims description 8
- 239000003643 water by type Substances 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 9
- 150000002632 lipids Chemical class 0.000 abstract description 8
- 230000035935 pregnancy Effects 0.000 abstract description 8
- 208000007502 anemia Diseases 0.000 abstract description 3
- 230000036772 blood pressure Effects 0.000 abstract description 3
- 230000007177 brain activity Effects 0.000 abstract description 3
- 210000003754 fetus Anatomy 0.000 abstract description 3
- 210000004185 liver Anatomy 0.000 abstract description 3
- 230000009758 senescence Effects 0.000 abstract description 3
- 230000001934 delay Effects 0.000 abstract description 2
- 229940060184 oil ingredients Drugs 0.000 abstract 3
- 235000019198 oils Nutrition 0.000 abstract 3
- 229960004106 citric acid Drugs 0.000 abstract 2
- 235000015165 citric acid Nutrition 0.000 abstract 2
- 229930003451 Vitamin B1 Natural products 0.000 abstract 1
- 229960003495 thiamine Drugs 0.000 abstract 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 abstract 1
- 235000010374 vitamin B1 Nutrition 0.000 abstract 1
- 239000011691 vitamin B1 Substances 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 241000208202 Linaceae Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of maternal nutritional replenishers, by the I soft capsule of cladding linolenic oil, the II soft capsule and III tablet of coating composition A forms, wherein: the weight ratio of linolenic oil and composition A and III tablet in I soft capsule is 1:(0.8-1.2): (0.5-1), the raw material for preparing of the composition A includes linolenic oil, lecithin and vitamin combination, the raw material for preparing of the III tablet includes D-mannital, ferrous fumarate, zinc lactate, taurine, Potassiumiodate, citric acid, citric acid, Aspartame, folic acid, vitamin B1, vitamin B2.Maternal nutritional replenishers of the invention; the nutritional need of pregnant woman can effectively be met; alleviate the pregnancy reaction of pregnant woman; blood lipid can be effectively adjusted, protection liver, brain activity is promoted, delays senescence; blood lipid is effectively reduced and reduces blood pressure; it avoids pregnant woman from malnutritive or Anemia occur, and avoids fetus from the problems such as depauperation, weak and sickly occur simultaneously.
Description
Technical field
The present invention relates to food technology field, in particular to a kind of maternal nutritional replenishers and preparation method thereof.
Background technique
Pregnant woman is frequently accompanied by that hyperlipidemia, liver function are bad, lack brain activity, easy aging, blood pressure during pregnancy
There is the problems such as depauperation, weak and sickly in the symptoms such as high, malnutritive or anaemia or even fetus.In addition, most of pregnant woman exists
Can all there be different degrees of pregnancy reaction in pregnancy period, thus be frequently accompanied by loss of appetite, nausea, retch, vomiting phenomena such as, this is non-
Enough nutrition cannot be absorbed by being often easy to cause, so that the above problem be further aggravated.
Based on this, it is necessary to develop a kind of pregnancy reaction for alleviating pregnant woman, can effectively adjust blood lipid, protection liver, mention
It rises brain activity, delay senescence, and the maternal nutritional replenishers of postprandial blood sugar are effectively reduced.
Summary of the invention
To solve the above-mentioned problems, the invention discloses a kind of maternal nutritional replenishers, soft by No. I of cladding linolenic oil
Capsule, the II soft capsule of coating composition A and III tablet composition, in which: linolenic oil in I soft capsule with combine
The weight ratio of object A and III tablet is 1:(0.8-1.2): (0.5-1), by weight, the raw material for preparing of composition A includes:
11.5 parts of linolenic oil
8-18 parts of lecithin
0.2-1 parts of vitamin combination；
By weight, the raw material for preparing of III tablet includes:
Preferably, the maternal nutritional replenishers, by the I soft capsule of cladding linolenic oil, the II of coating composition A
Number soft capsule and III tablet composition, in which: the weight of linolenic oil and composition A and III tablet in I soft capsule
Than for 1:(0.8-1.2): (0.5-1),
By weight, the raw material for preparing of composition A includes:
11.5 parts of linolenic oil
10-15 parts of lecithin
0.3-0.5 parts of vitamin combination；
By weight, the raw material for preparing of III tablet includes:
More preferably, the maternal nutritional replenishers, by the I soft capsule of cladding linolenic oil, the II of coating composition A
Number soft capsule and III tablet composition, in which: the weight of linolenic oil and composition A and III tablet in I soft capsule
Than for 1:(0.8-1.2): (0.5-1),
By weight, the raw material for preparing of composition A includes:
11.5 parts of linolenic oil
13.8 parts of lecithin
0.4101 part of vitamin combination；
By weight, the raw material for preparing of III tablet includes:
Most preferably, the maternal nutritional replenishers, by the I soft capsule of cladding linolenic oil, the II of coating composition A
Number soft capsule and III tablet composition, in which: by weight,
Linolenic oil in I soft capsule is 20.7 parts；
Composition A in II soft capsule is 25.7101 parts, prepares raw material are as follows:
11.5 parts of linolenic oil
13.8 parts of lecithin
0.4101 part of vitamin combination；
III tablet is 17.2499 parts, prepares raw material are as follows:
Preferably, the II soft capsule and III tablet of the I soft capsule of the cladding linolenic oil, coating composition A
It is taken respectively early, middle and late.
Preferably, the vitamin combination is at least two combination in VitAVitE and vitamin D.
Preferably, the vitamin combination is the combination of VitAVitE and vitamin D three.
Preferably, the weight ratio of VitAVitE and vitamin D is 8:(10-50 in the vitamin combination):
(0.001-0.02)；More preferably 8:33:0.01.
The present invention also provides the preparation methods of maternal nutritional replenishers, comprising the following steps:
(1) it prepares capsule shells glue: the water dissolving type glue tank containing purified water being heated, is under stiring added to glycerol
It is stirred evenly in the change glue tank, obtains mixed liquor；Gelatin stirring, tanning, vacuumizing and defoaming, plastic emitting, to make are added into mixed liquor
For capsule shells glue；
(2) I soft capsule: the first step is prepared, it is accurate that the linolenic oil of recipe quantity is weighed, and adds together with capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule.
(3) II soft capsule: the first step is prepared, vitamin D addition linolenic oil is heated to being completely dissolved uniformly；Second
Step, vitamin A is added in first step solution, is evenly stirred until no precipitating；Third step, by flax of recipe quantity half
Sour oil and the lecithin of half are poured into agitator tank and are mixed evenly, then the stirring of raw material agitator tank is added in vitamin E
Uniformly；Raw material agitator tank is added in second step and remaining linolenic oil and lecithin by the 4th step；5th step, by second step,
Three steps, the 4th step mixed liquor be mixed evenly；6th step, pelleting；7th step, drying of being formed；8th step examines ball.
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step will be formulated
Amount folic acid, B1, B2 are uniformly mixed with formula ratio Aspartame, citric acid；Third step is by ferrous fumarate, zinc lactate, taurine
It is uniformly mixed with a small amount of D-mannital；Potassiumiodate is uniformly mixed by the 4th step with a small amount of D-mannital；5th step will remain
Remaining mannitol, second step mixture, third step mixture, the 4th step are added in mixing machine and are uniformly mixed；6th step is added
Softwood processed, the 7th step, by soft material granulation are shredded in adhesive stirring；8th step, the pellet made is dry with boiling drier, control
Drying temperature processed is dried to abundant；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st step, coating.
Preferably, the preparation method of the maternal nutritional replenishers, comprising the following steps:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 32.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin D is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
6 parts of linolenic oils and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin E
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are mixed with 0.08 part of Aspartame, 0.32 part of citric acid
Uniformly；Third step mixes 0.84 part of ferrous fumarate, 0.72 part of zinc lactate, 0.69 part of taurine and 2.5349 parts of D-mannitals
It closes uniform；0.005 part of Potassiumiodate is uniformly mixed by the 4th step with 1 part of D-mannital；5th step, by 10 parts of mannitols,
Two step mixtures, third step mixture, the 4th step mixture are added in mixing machine and are uniformly mixed；6th step adds into mixing machine
Enter 1 part of starch slurry, softwood processed is shredded in stirring；7th step, by soft material granulation；8th step, the pellet boiling drier that will be made
It is dry, control drying temperature to abundant drying；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st
Step, coating, obtains III tablet.
The present invention provides following advantageous effects:
1, the various nutrients lacked are easy the pregnancy period containing pregnant woman, can effectively adjust blood lipid, protection liver, is promoted greatly
Brain vigor delays senescence；
2, the effect of present invention is by between heterogeneity raw material is complementary, reaches synergy, is effectively reduced to realize
Reduce and blood lipid and reduce blood pressure, pregnant woman is avoided malnutritive or Anemia occur, and avoid simultaneously fetus occur depauperation,
The problems such as weak and sickly；
3, pregnancy reaction is effectively relieved.
Specific embodiment
It is clearly and completely described below in conjunction with the technical solution in the embodiment of the present invention, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff every other embodiment obtained without making creative work belongs to what the present invention protected
Range.
Following No. I, the medicament total weight in II soft capsule be 2.5 grams, the weight of III tablet is 3 grams.
Embodiment 1
Maternal nutritional replenishers are prepared, steps are as follows:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 32.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin D is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
6 parts of linolenic oils and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin E
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are mixed with 0.08 part of Aspartame, 0.32 part of citric acid
Uniformly；Third step mixes 0.84 part of ferrous fumarate, 0.72 part of zinc lactate, 0.69 part of taurine and 2.5349 parts of D-mannitals
It closes uniform；0.005 part of Potassiumiodate is uniformly mixed by the 4th step with 1 part of D-mannital；5th step, by 10 parts of mannitols,
Two step mixtures, third step mixture, the 4th step mixture are added in mixing machine and are uniformly mixed；6th step adds into mixing machine
Enter 1 part of starch slurry, softwood processed is shredded in stirring；7th step, by soft material granulation；8th step, the pellet boiling drier that will be made
It is dry, control drying temperature to abundant drying；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st
Step, coating, obtains III tablet；
(5) I soft capsule, II soft capsule and III tablet are packaged on clad plate simultaneously, for use.
Comparative example 1
Maternal nutritional replenishers are prepared, steps are as follows:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 32.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin B is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
6 parts of linolenic oils and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin E
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are mixed with 0.08 part of Aspartame, 0.32 part of citric acid
Uniformly；Third step mixes 0.84 part of ferrous fumarate, 0.72 part of zinc lactate, 0.69 part of taurine and 2.5349 parts of D-mannitals
It closes uniform；0.005 part of Potassiumiodate is uniformly mixed by the 4th step with 1 part of D-mannital；5th step, by 10 parts of mannitols,
Two step mixtures, third step mixture, the 4th step mixture are added in mixing machine and are uniformly mixed；6th step adds into mixing machine
Enter 1 part of starch slurry, softwood processed is shredded in stirring；7th step, by soft material granulation；8th step, the pellet boiling drier that will be made
It is dry, control drying temperature to abundant drying；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st
Step, coating, obtains III tablet；
(5) I soft capsule, II soft capsule and III tablet are packaged on clad plate simultaneously, for use.
Comparative example 2
Maternal nutritional replenishers are prepared, steps are as follows:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 32.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin D is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
6 parts of linolenic oils and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin D
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are mixed with 0.08 part of Aspartame, 0.32 part of citric acid
Uniformly；Third step mixes 0.84 part of ferrous fumarate, 0.72 part of zinc lactate, 0.69 part of taurine and 2.5349 parts of D-mannitals
It closes uniform；0.005 part of Potassiumiodate is uniformly mixed by the 4th step with 1 part of D-mannital；5th step, by 10 parts of mannitols,
Two step mixtures, third step mixture, the 4th step mixture are added in mixing machine and are uniformly mixed；6th step adds into mixing machine
Enter 1 part of starch slurry, softwood processed is shredded in stirring；7th step, by soft material granulation；8th step, the pellet boiling drier that will be made
It is dry, control drying temperature to abundant drying；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st
Step, coating, obtains III tablet；
(5) I soft capsule, II soft capsule and III tablet are packaged on clad plate simultaneously, for use.
Comparative example 3
Maternal nutritional replenishers are prepared, steps are as follows:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 20.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0005 part of vitamin D is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
8 parts of linolenic oils and 9.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin E
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are mixed with 0.08 part of Aspartame, 0.32 part of citric acid
Uniformly；Third step mixes 0.84 part of ferrous fumarate, 0.72 part of zinc lactate, 0.69 part of taurine and 2.5349 parts of D-mannitals
It closes uniform；0.005 part of Potassiumiodate is uniformly mixed by the 4th step with 1 part of D-mannital；5th step, by 10 parts of mannitols,
Two step mixtures, third step mixture, the 4th step mixture are added in mixing machine and are uniformly mixed；6th step adds into mixing machine
Enter 1 part of starch slurry, softwood processed is shredded in stirring；7th step, by soft material granulation；8th step, the pellet boiling drier that will be made
It is dry, control drying temperature to abundant drying；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st
Step, coating, obtains III tablet；
(5) I soft capsule, II soft capsule and III tablet are packaged on clad plate simultaneously, for use.
Comparative example 4
Maternal nutritional replenishers are prepared, steps are as follows:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 32.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin D is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
6 parts of linolenic oils and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin E
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are mixed with 0.08 part of Aspartame, 0.32 part of citric acid
Uniformly；0.69 part of taurine is uniformly mixed by third step with 2.5349 parts of D-mannitals；4th step, by 0.005 part of Potassiumiodate
It is uniformly mixed with 1 part of D-mannital；5th step, by 10 parts of mannitols, second step mixture, third step mixture, the 4th
It walks and is uniformly mixed in mixture addition mixing machine；1 part of starch slurry is added into mixing machine for 6th step, and softwood processed is shredded in stirring；The
Seven steps, by soft material granulation；8th step, the pellet made is dry with boiling drier, control drying temperature to abundant drying；The
Dried particle is uniformly mixed by nine steps；Tenth step, tabletting；11st step, coating, obtains III tablet；
(5) I soft capsule, II soft capsule and III tablet are packaged on clad plate simultaneously, for use.
Comparative example 5
Maternal nutritional replenishers are prepared, steps are as follows:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, is being stirred
It mixes lower 12.04 parts of glycerol are added in the change glue tank to stir evenly, obtains mixed liquor；25.3 parts of gelatin are added into mixed liquor to stir
It mixes, tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: the first step adds 32.2 parts of linolenic oil together with 20 parts of above-mentioned capsule shells glue
Enter in head tank, stirs evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin D is added in 1 part of linolenic oil, has been heated to
Fully dissolved is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step,
6 parts of linolenic oils and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material is added in 0.33 part of vitamin E
Agitator tank stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins
Ester and 17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；The mixed liquor of 4th step is mixed and is stirred by the 5th step
It mixes uniformly；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, will
0.007 part of folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are uniformly mixed with 0.32 part of citric acid；Third step will
0.72 part of zinc lactate, 0.69 part of taurine are uniformly mixed with 2.5349 parts of D-mannitals；4th step, by 0.005 part of Potassiumiodate
It is uniformly mixed with 1 part of D-mannital；5th step, by 10 parts of mannitols, second step mixture, third step mixture, the 4th
It walks and is uniformly mixed in mixture addition mixing machine；1 part of starch slurry is added into mixing machine for 6th step, and softwood processed is shredded in stirring；The
Seven steps, by soft material granulation；8th step, the pellet made is dry with boiling drier, control drying temperature to abundant drying；The
Dried particle is uniformly mixed by nine steps；Tenth step, tabletting；11st step, coating, obtains III tablet；
(5) I soft capsule, II soft capsule and III tablet are packaged on clad plate simultaneously, for use.
Test
It is unfolded to cooperate with women and children hospital of Beijing, collection 500 is pregnant in pregnant early stage in the pregnant woman of women and children's hospital admission
It is pregnent and reacts volunteer serious and that blood lipid is high, 50 people are one group, test above-described embodiment 1 and the nutrition of comparative example 1-5 respectively
The using effect of powder, test period are 30 days, specially it is daily it is early, middle and late take respectively I soft capsule, II soft capsule with
And III tablet.After 30 days, according to the practical impression (the number ratio that pregnancy reaction is relieved) of volunteer and blood lipid is just
Normal rate (blood lipid restores normal number ratio) evaluates the effect of embodiment 1 and comparative example 1-5, and test result see the table below.
Table 1
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of maternal nutritional replenishers, by the I soft capsule of cladding linolenic oil, coating composition A II soft capsule and
III tablet composition, in which: the weight ratio of linolenic oil and composition A and III tablet in I soft capsule is 1:(0.8-
1.2): (0.5-1), which is characterized in that
By weight, the raw material for preparing of composition A includes:
11.5 parts of linolenic oil
8-18 parts of lecithin
0.2-1 parts of vitamin combination；
By weight, the raw material for preparing of III tablet includes:
2. maternal nutritional replenishers according to claim 1, by the I soft capsule of cladding linolenic oil, coating composition A
II soft capsule and III tablet composition, in which: linolenic oil in I soft capsule and composition A and III tablet
Weight ratio is 1:(0.8-1.2): (0.5-1), which is characterized in that
By weight, the raw material for preparing of composition A includes:
11.5 parts of linolenic oil
10-15 parts of lecithin
0.3-0.5 parts of vitamin combination；
By weight, the raw material for preparing of III tablet includes:
3. maternal nutritional replenishers according to claim 2, by the I soft capsule of cladding linolenic oil, coating composition A
II soft capsule and III tablet composition, in which: linolenic oil in I soft capsule and composition A and III tablet
Weight ratio is 1:(0.8-1.2): (0.5-1), which is characterized in that
By weight, the raw material for preparing of composition A includes:
11.5 parts of linolenic oil
13.8 parts of lecithin
0.4101 part of vitamin combination；
By weight, the raw material for preparing of III tablet includes:
4. maternal nutritional replenishers according to claim 3, by the I soft capsule of cladding linolenic oil, coating composition A
II soft capsule and III tablet composition, in which: by weight,
Linolenic oil in I soft capsule is 20.7 parts；
Composition A in II soft capsule is 25.7101 parts, prepares raw material are as follows:
11.5 parts of linolenic oil
13.8 parts of lecithin
0.4101 part of vitamin combination；
III tablet is 17.2499 parts, prepares raw material are as follows:
5. maternal nutritional replenishers according to claim 1-4, which is characterized in that the cladding linolenic oil
I soft capsule, the II soft capsule of coating composition A and III tablet are taken early, middle and late respectively.
6. maternal nutritional replenishers according to claim 1-5, which is characterized in that the vitamin combination is
At least two combination in VitAVitE and vitamin D.
7. maternal nutritional replenishers according to claim 6, which is characterized in that the vitamin combination be vitamin A,
The combination of vitamin E and vitamin D three.
8. maternal nutritional replenishers according to claim 7, which is characterized in that vitamin A in the vitamin combination,
The weight ratio of vitamin E and vitamin D is 8:(10-50): (0.001-0.02)；Preferably 8:33:0.01.
9. the preparation method of maternal nutritional replenishers, which comprises the following steps:
(1) it prepares capsule shells glue: the water dissolving type glue tank containing purified water being heated, glycerol is added to the change under stiring
It is stirred evenly in glue tank, obtains mixed liquor；Gelatin stirring, tanning, vacuumizing and defoaming, plastic emitting, using as glue are added into mixed liquor
Softgel shell glue；
(2) I soft capsule: the first step is prepared, it is accurate that the linolenic oil of recipe quantity is weighed, and original is added together with glue with capsule shells
In batch can, stir evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule.
(3) II soft capsule: the first step is prepared, vitamin D addition linolenic oil is heated to being completely dissolved uniformly；Second step,
Vitamin A is added in first step solution, is evenly stirred until no precipitating；Third step, by the linolenic acid of recipe quantity half
Oil and the lecithin of half are poured into agitator tank and are mixed evenly, then the stirring of raw material agitator tank is added in vitamin E
It is even；Raw material agitator tank is added in second step and remaining linolenic oil and lecithin by the 4th step；5th step, by second step, third
It walks, the mixed liquor of the 4th step is mixed evenly；6th step, pelleting；7th step, drying of being formed；8th step examines ball.
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, by formula ratio leaf
Acid, B1, B2 are uniformly mixed with formula ratio Aspartame, citric acid；Third step is by ferrous fumarate, zinc lactate, taurine and lacks
D-mannital is measured to be uniformly mixed；Potassiumiodate is uniformly mixed by the 4th step with a small amount of D-mannital；5th step, will be remaining
Mannitol, second step mixture, third step mixture, the 4th step are added in mixing machine and are uniformly mixed；Bonding is added in 6th step
Softwood processed, the 7th step, by soft material granulation are shredded in agent stirring；8th step, the pellet made is dry with boiling drier, and control is dry
Dry temperature is dried to abundant；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st step, coating.
10. the preparation method of maternal nutritional replenishers according to claim 9, which comprises the following steps:
(1) it prepares capsule shells glue: by weight, the water dissolving type glue tank containing 12.04 parts of purified waters being heated, under stiring
12.04 parts of glycerol are added in the change glue tank and are stirred evenly, mixed liquor is obtained；25.3 parts of gelatin stirrings are added into mixed liquor,
Tanning, vacuumizing and defoaming, plastic emitting, using as capsule shells glue；
(2) prepare I soft capsule: original is added with 20 parts of above-mentioned capsule shells in 32.2 parts of linolenic oil by the first step together with glue
In batch can, stir evenly；Second step, pelleting；Third step, drying of being formed；4th step examines ball, obtains I soft capsule；
(3) II soft capsule: the first step is prepared, 0.0001 part of vitamin D is added in 1 part of linolenic oil, is heated to completely molten
Solution is uniform；0.08 part of vitamin A is added in first step solution, is evenly stirred until no precipitating by second step；Third step, by 6 parts
Linolenic oil and 6.9 parts of lecithins are poured into agitator tank and are mixed evenly, then raw material agitator tank is added in 0.33 part of vitamin E
It stirs evenly；4th step, by second step acquired solution, third step acquired solution and 4 parts of linolenic oils and 6.9 parts of lecithins and
17.34 parts of above-mentioned capsule shells are added in raw material agitator tank together with glue；5th step the mixed liquor of the 4th step is mixed equal
It is even；6th step, pelleting；7th step, drying of being formed；8th step examines ball, obtains II soft capsule；
(4) prepare III tablet: material used in III tablet is weighed by formula by the first step；Second step, by 0.007 part
Folic acid, 0.028 part of vitamin B1,0.025 part of vitamin B2 are uniformly mixed with 0.08 part of Aspartame, 0.32 part of citric acid；The
0.84 part of ferrous fumarate, 0.72 part of zinc lactate, 0.69 part of taurine are uniformly mixed by three steps with 2.5349 parts of D-mannitals；
0.005 part of Potassiumiodate is uniformly mixed by the 4th step with 1 part of D-mannital；5th step mixes 10 parts of mannitols, second steps
Object, third step mixture, the 4th step mixture is closed to be added in mixing machine and be uniformly mixed；6th step, starch is added into mixing machine
Softwood processed is shredded in 1 part of slurry, stirring；7th step, by soft material granulation；8th step, the pellet made is dry with boiling drier, control
Drying temperature processed is dried to abundant；Dried particle is uniformly mixed by the 9th step；Tenth step, tabletting；11st step, coating,
Obtain III tablet.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020044961A1 (en) * | 1999-05-27 | 2002-04-18 | Drugtech Corporation | Nutritional formulations |
| CN103039605A (en) * | 2012-12-21 | 2013-04-17 | 内蒙古伊利实业集团股份有限公司 | Pregnant woman milk powder capable of restraining early pregnancy reaction and preparation method thereof |
| CN103181568A (en) * | 2013-03-26 | 2013-07-03 | 汉中永杨医药科技发展有限公司 | Eucommia seed oil vitamin compound soft capsule preparation and preparation method thereof |
| CN105106217A (en) * | 2015-08-13 | 2015-12-02 | 淄博维克勋医药技术有限公司 | Nutritional supplement for pregnant women and preparation method thereof |
| CN106617075A (en) * | 2017-01-18 | 2017-05-10 | 济南善恩医药科技有限公司 | Compounded flax-seed oil microcapsule powder and preparation method thereof |
-
2018
- 2018-08-30 CN CN201811005667.5A patent/CN109170904A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020044961A1 (en) * | 1999-05-27 | 2002-04-18 | Drugtech Corporation | Nutritional formulations |
| CN103039605A (en) * | 2012-12-21 | 2013-04-17 | 内蒙古伊利实业集团股份有限公司 | Pregnant woman milk powder capable of restraining early pregnancy reaction and preparation method thereof |
| CN103181568A (en) * | 2013-03-26 | 2013-07-03 | 汉中永杨医药科技发展有限公司 | Eucommia seed oil vitamin compound soft capsule preparation and preparation method thereof |
| CN105106217A (en) * | 2015-08-13 | 2015-12-02 | 淄博维克勋医药技术有限公司 | Nutritional supplement for pregnant women and preparation method thereof |
| CN106617075A (en) * | 2017-01-18 | 2017-05-10 | 济南善恩医药科技有限公司 | Compounded flax-seed oil microcapsule powder and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 全国卫生专业技术资格考试专家委员会: "《药学》", 29 February 2004, 山东大学出版社 * |
| 梁艺英: "《保健食品研发与审评》", 30 November 2012, 中国医药科技出版社 * |
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