CN104382934A - Multivitamin tablet for pregnant women - Google Patents
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- CN104382934A CN104382934A CN201310359849.3A CN201310359849A CN104382934A CN 104382934 A CN104382934 A CN 104382934A CN 201310359849 A CN201310359849 A CN 201310359849A CN 104382934 A CN104382934 A CN 104382934A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Abstract
The invention relates to a multivitamin tablet for pregnant women. 1000 multivitamin tablets contain the following materials: 1-2g of vitamin A, 5.5-6.5g of vitamin E, 0.1-0.4g of vitamin B1, 0.2-0.5g of vitamin B2, 0.2-0.45g of vitamin B6, 0.02-0.06g of vitamin B12, 20-35g of vitamin C, 0.3-0.6g of vitamin D3, 0.05-0.15g of folic acid, 450-550g of calcium carbonate, 38.5-40g of ferrous gluconate, 20-30g of zinc gluconate, 0.35-0.65g of Seleno-k-carrageenan, 2-4g of nicotinic acid, 218-238g of starch, 140-150g of dextrin, 2-7g of magnesium stearate, 15-25g of polyvinylpyrrolidone, 18g of hydroxypropyl methylcellulose, 3g of polyethylene glycol, 6g of titanium dioxide and 3g of talcum powder. The tablet provided by the invention contains various vitamins required by pregnant women and trace elements such as calcium, iron, zinc and the like, and can provide multiple elements for normal growth of fetus. By the use of the tablet, growth of fetus is promoted, and aberration rate of fetus is reduced.
Description
Technical field
The invention belongs to field of health care products, relate to a kind of multidimensional sheet specifically, be especially applicable to the multidimensional sheet that anemia of pregnant woman uses.
Background technology
Vitamin and mineral are generally as the use of nutriment, research shows, vitamin and mineral play important physiological action, no crowd needs not consumption and without the vitamin of type and mineral, to prevent or palliate a disease and maintain normal healthy state, particularly anemia of pregnant woman, because the special relationship of pregnancy, need no vitamin and mineral supplement maintain or provide pregnant woman health and and proper fetal development, current pill or the bad absorption of tablet, and nutritional labeling is single.
Summary of the invention
In order to solve the problem, the invention provides the tablet that a kind of absorption that multivitamin can be provided to need for anemia of pregnant woman is fast and many.
In order to achieve the above object, the present invention is achieved by the following technical solutions:
The present invention is a kind of anemia of pregnant woman's multidimensional sheet, every 1000 materials comprising following weight of multidimensional sheet: vitamin A 1-2g, vitamin E 5.5-6.5 g, vitamin B
10.1-0.4 g, vitamin B
20.2-0.5 g, vitamin B
60.2-0.45 g, vitamin B
120.02-0.06 g, Catergen 0-35 g, vitamin D
30.3-0.6 g, folic acid
0.05-0.15 g, calcium carbonate
450-550 g, Ferrous gluconate 38.5-40 g, zinc gluconate 20-30 g, selenocarrageenan 0.35-0.65 g, nicotinic acid 2-4 g, starch 218-238 g, dextrin 140-150 g, magnesium stearate 2-7 g, polyvidone 15-25 g, hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g.
As preferred version of the present invention be: described multidimensional sheet every 1000 comprises the material of following weight: vitamin A 1.6g, vitamin E 5.8 g, vitamin B
10.3 g, vitamin B
20.2-0.5 g, vitamin B
60.36 g, vitamin B
120.05g, Catergen 5 g, vitamin D
30.48 g, folic acid
0.11 g, calcium carbonate
500 g, Ferrous gluconate 39.1 g, zinc gluconate 25 g, selenocarrageenan 0.475 g, nicotinic acid 3 g, starch 228.375 g, dextrin 145 g, magnesium stearate 5g, polyvidone 20 g, hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g.
Make above-mentioned anemia of pregnant woman's multidimensional sheet to comprise the steps:
(1) sieve, weigh, mix: folic acid, vitamin B
12, vitamin B
1, vitamin B
6, vitamin B
2, vitamin D
3,selenocarrageenan sieves respectively, mixes 10 minutes, obtain mixed powder 1, VitAVitE, nicotinic acid are sieved respectively, mix 10 minutes obtain mixed powder 2 after weighing according to the above ratio with mixed powder 1 after weighing according to the above ratio; Vitamin C is mixed 10 minutes with mixed powder 2, obtains mixed powder 3; Dextrin is sieved, mixes 10 minutes with mixed powder 3 after weighing according to aforementioned proportion and obtain mixed powder 4; To weigh mixing 10 minutes according to aforementioned proportion after Ferrous gluconate, zinc gluconate are sieved, obtain mixed powder 5, starch, calcium carbonate are sieved respectively, with mixed of mixed powder 5 10 minutes after weighing according to aforementioned proportion, obtain mixed powder 6;
(2) soft material processed: the alcoholic solution preparing 5% polyvidone, is joined in above-mentioned mixed powder 4, and obtained soft material 1, prepares the alcoholic solution of 5% polyvidone, joined in mixed powder 6, obtained soft material 2;
(3) granulate: above-mentioned soft material 1 is put into granulator and granulates, sieve to obtain wet granular 1, soft material 2 put into granulator and granulates, sieve, obtain wet granular 2;
(4) dry, granulate: the dry 4-5 hour at-50 DEG C of temperature by wet granular 1 and wet granular 2 respectively, granulate after sieving, obtains dry granule 1 and dry granule 2;
(5) mix: after dry granule 1 and dry granule 2 are mixed 30 minutes, obtain mixture;
(6) always mix: weighing after magnesium stearate according to aforementioned proportion mixes 10 minutes with said mixture, obtains total mixture;
(7) tabletting: by above-mentioned total mixture tabletting, obtains plain sheet 1g/ sheet;
(8) coating: by hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g and pure water are mixed with film coating liquid, carry out coating, obtain Film coated tablets to plain sheet;
(9) select, pack: select qualified product and pack, 50 slices/bottle.
The invention has the beneficial effects as follows: multidimensional sheet of the present invention, provide multivitamin A, vitamin E, the vitamin B needed for anemia of pregnant woman
1, vitamin B
2, vitamin B
6, vitamin B
12, vitamin C, vitamin D
3, folic acid, and the material of the needed by human body such as calcium ferrum zinc, supplement anemia of pregnant woman or the nutrition needed for women's diet of age of sucking, various vitamin promotes foetus health growth, promotes the absorption of calcium, safeguards the growth of skeleton, build up resistance, tablet in the present invention is the DRIs standard formulation of announcing according to Chinese Soclety of Nutrition, is all dissolved in tablet by all nutrients, is easier to digesting and assimilating of human body.
Tablet of the present invention contains the trace element such as vitamin and calcium ferrum zinc had needed for anemia of pregnant woman more, all can have element for the normal growth of fetus provides more, decrease fetal anomaly rate.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
Detailed description of the invention
In order to deepen the understanding of the present invention, be described in further detail the present invention below in conjunction with drawings and Examples, this embodiment, only for explaining the present invention, not forming protection scope of the present invention and limiting.
As shown in Fig. 1, the present invention is a kind of anemia of pregnant woman's multidimensional sheet, every 1000 materials comprising following weight of described multidimensional sheet: vitamin A 1-2g, vitamin E 5.5-6.5 g, vitamin B
10.1-0.4 g, vitamin B
20.2-0.5 g, vitamin B
60.2-0.45 g, vitamin B
120.02-0.06 g, Catergen 0-35 g, vitamin D
30.3-0.6 g, folic acid
0.05-0.15 g, calcium carbonate
450-550 g, Ferrous gluconate 38.5-40 g, zinc gluconate 20-30 g, selenocarrageenan 0.35-0.65 g, nicotinic acid 2-4 g, starch 218-238 g, dextrin 140-150 g, magnesium stearate 2-7 g, polyvidone 15-25 g, hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g.
Embodiment one
A kind of anemia of pregnant woman's multidimensional sheet, described multidimensional sheet every 1000 comprises the material of following weight: vitamin A 1.6g, vitamin E 5.8 g, vitamin B
10.3 g, vitamin B
20.2-0.5 g, vitamin B
60.36 g, vitamin B
120.05g, Catergen 5 g, vitamin D
30.48 g, folic acid
0.11 g, calcium carbonate
500 g, Ferrous gluconate 39.1 g, zinc gluconate 25 g, selenocarrageenan 0.475 g, nicotinic acid 3 g, starch 228.375 g, dextrin 145 g, magnesium stearate 5g, polyvidone 20 g, hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g.
Make above-mentioned anemia of pregnant woman's multidimensional sheet to comprise the steps:
(1) sieve, weigh, mix: folic acid, vitamin B
12, vitamin B
1, vitamin B
6, vitamin B
2, vitamin D
3,selenocarrageenan sieves respectively, mixes 10 minutes, obtain mixed powder 1, VitAVitE, nicotinic acid are sieved respectively, mix 10 minutes obtain mixed powder 2 after weighing according to the above ratio with mixed powder 1 after weighing according to the above ratio; Vitamin C is mixed 10 minutes with mixed powder 2, obtains mixed powder 3; Dextrin is sieved, mixes 10 minutes with mixed powder 3 after weighing according to aforementioned proportion and obtain mixed powder 4; To weigh mixing 10 minutes according to aforementioned proportion after Ferrous gluconate, zinc gluconate are sieved, obtain mixed powder 5, starch, calcium carbonate are sieved respectively, with mixed of mixed powder 5 10 minutes after weighing according to aforementioned proportion, obtain mixed powder 6;
(2) soft material processed: the alcoholic solution preparing 5% polyvidone, is joined in above-mentioned mixed powder 4, and obtained soft material 1, prepares the alcoholic solution of 5% polyvidone, joined in mixed powder 6, obtained soft material 2;
(3) granulate: above-mentioned soft material 1 is put into granulator and granulates, sieve to obtain wet granular 1, soft material 2 put into granulator and granulates, sieve, obtain wet granular 2;
(4) dry, granulate: the dry 4-5 hour at-50 DEG C of temperature by wet granular 1 and wet granular 2 respectively, granulate after sieving, obtains dry granule 1 and dry granule 2;
(5) mix: after dry granule 1 and dry granule 2 are mixed 30 minutes, obtain mixture;
(6) always mix: weighing after magnesium stearate according to aforementioned proportion mixes 10 minutes with said mixture, obtains total mixture;
(7) tabletting: by above-mentioned total mixture tabletting, obtains plain sheet 1g/ sheet;
(8) coating: by hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g and pure water are mixed with film coating liquid, carry out coating, obtain Film coated tablets to plain sheet;
(9) select, pack: select qualified product and pack, 50 slices/bottle.
Vitamin A promotes the biosynthesis of protein and the differentiation of osteocyte, contribute to cell proliferation and growth, vitamin A can the synthesis of involved in sugar albumen, this normal formation for epithelium, grow with maintenance very important, anemia of pregnant woman uses and can promote fetal development, strong skeleton;
Vitamin E makes woman's estrogen concentration increase, and improves fertility, prevention of miscarriage;
Vitamin B
1can help digest, particularly the digestion of carbohydrate, improve the situation of the psychentonia of anemia of pregnant woman, maintain nervous tissue, muscle, cardiomotility normal;
Vitamin B
2participating in the metabolism of vitamin B6 and nicotinic acid, is a model of vitamin B group coordinative role, and major physiological functions promotes metabolism as coenzyme;
Vitamin B
6participate in protein synthesis and catabolism, participate in all amino acid metabolisms, as relevant with the metabolism of haemachrome, to synthesize nicotinic acid relevant with tryptophan, involved in sugar heteroplasia, UFA metabolism.With glycogen, sphingomyelin is relevant with the metabolism of steroid, participate in some neurohumoral synthesis, vitamin B6 and one carbon unit, the metabolism of vitamin B12 and folate, if their dysbolismus can cause megaloblastic anemia, participate in nucleic acid and DNA synthesis, shortage can damage the synthesis of DNA, it is very important that this process maintains suitable immunologic function to anemia of pregnant woman, the relation of vitamin B6 and vitamin B2 is very close, Vitamin B6 deficiency is often with vitamin B2 symptom, participate in the conversion of homocysteine to methionine, there is the effect reducing chronic disease, slight hyperhomocysteinemiainjury is considered to a kind of potentially dangerous factor of angiopathy, the intervention of vitamin B6 can reduce homocysteine in plasma content,
Vitamin B
12be used for the treatment of and prevent vitamin B12 deficiency disease, for supplementing because of wasting diseases, gestation, the vitamin B12 increase in demand that suckling etc. cause, trophism and gestational anemia etc.;
Vitamin C Main Function improves immunity, prophylaxis of cancer, heart disease, apoplexy, takes care of one's teeth and gingiva etc.In addition, adhere to that taking vitamin c can also make dermal melanin calmness reduce on time, thus reduce black speck and freckle, make whitening skin, adult and the ascorbic recommended intake of pregnant early stage women are 100mg/d, and Mid and late pregnant women and the ascorbic recommended intake of wet nurse are 130mg/d;
Vitamin D
3improve human body to the absorption of calcium, phosphorus, the level of plasma calcium and blood plasma phosphorus is reached capacity degree; Growth promoting effects and skeleton calcification, promote that tooth perfects; Maintain the normal level of citrate in blood; Prevent aminoacid from being lost by kidney, for rickets, osteomalacia and infantile tetany;
Folic acid is the necessary material of human body when utilizing sugar and aminoacid, it is the necessary material of body cell Growth and reproduction, folic acid in vivo folic acid works with the form of tetrahydrofolic acid, tetrahydrofolic acid participates in synthesis and the conversion of purine nucleic acid and pyrimidine nucleotide in vivo, folic acid is at manufacture nucleic acid (ribonucleic acid, DNA (deoxyribonucleic acid)) on play the part of important role, folic acid helps the metabolism of protein, and jointly promote erythrocytic generation and maturation with vitamin B12, manufacture the indispensable material of erythrocyte, folic acid is the indispensable nutrient of embryo growth and development, anemia of pregnant woman lacks folic acid and likely causes occurring under-weight during fetal birth, harelip, heart defect etc., if lack folic acid at conceived in 3 months, fetal neural tube developmental defect can be caused, and cause deformity.Therefore, prepare conceived women, just can start to take 100 micrograms every day to 300 folic before pregnancy;
Calcium carbonate, grape saccharic acid ferrous iron and zinc gluconate provide the materials such as the calcium ferrum zinc of human body particularly needed for anemia of pregnant woman, are that normal fetal is grown;
Selenocarrageenan immunity moderation function, selenocarrageenan can be used as immune non-specific stimulating factor, stimulates humoral immunization and cell immune system, and immune stimulatory globulin and antibody produce, the immunologic function of enhancing body, contributes to the immunocompetence improving liver self;
Nicotinic acid is one of vitamin of needed by human, be a kind of water soluble vitamins, nicotinic acid is converted into nicotiamide in human body, and nicotiamide is the ingredient of cozymase and codehydrogenase Ⅱ, participate in HypercholesterolemicRats, the oxidizing process of Tissue respiration and the process of saccharide anaerobic decomposition.
Above-mentioned substance constitutes the main component of multidimensional sheet, and the plain sheet of multidimensional sheet carries out coating by the coating powder be made up of hypromellose, Polyethylene Glycol, titanium dioxide and Pulvis Talci again, is then being wrapped inside dress.
The production of product of the present invention performs in strict accordance with the pertinent regulations of health food Good Manufacture Practice, production process from raw material to inner packing is all carried out in 300,000 grades of clean areas, the inspection of microorganism meets the regulation of GB16740, and can guarantee that microbiological indicator is qualified within the shelf-life.
Claims (3)
1. anemia of pregnant woman's multidimensional sheet, is characterized in that: every 1000 materials comprising following weight of described multidimensional sheet: vitamin A 1-2g, vitamin E 5.5-6.5 g, vitamin B
10.1-0.4 g, vitamin B
20.2-0.5 g, vitamin B
60.2-0.45 g, vitamin B
120.02-0.06 g, Catergen 0-35 g, vitamin D
30.3-0.6 g, folic acid
0.05-0.15 g, calcium carbonate
450-550 g, Ferrous gluconate 38.5-40 g, zinc gluconate 20-30 g, selenocarrageenan 0.35-0.65 g, nicotinic acid 2-4 g, starch 218-238 g, dextrin 140-150 g, magnesium stearate 2-7 g, polyvidone 15-25 g, hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g.
2. a kind of anemia of pregnant woman's multidimensional sheet according to claim 1, is characterized in that: described multidimensional sheet every 1000 comprises the material of following weight: vitamin A 1.6g, vitamin E 5.8 g, vitamin B
10.3 g, vitamin B
20.2-0.5 g, vitamin B
60.36 g, vitamin B
120.05g, Catergen 5 g, vitamin D
30.48 g, folic acid
0.11 g, calcium carbonate
500 g, Ferrous gluconate 39.1 g, zinc gluconate 25 g, selenocarrageenan 0.475 g, nicotinic acid 3 g, starch 228.375 g, dextrin 145 g, magnesium stearate 5g, polyvidone 20 g, hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g.
3. a kind of anemia of pregnant woman's multidimensional sheet according to claim 1, is characterized in that: make above-mentioned anemia of pregnant woman's multidimensional sheet and comprise the steps:
(1) sieve, weigh, mix: folic acid, vitamin B
12, vitamin B
1, vitamin B
6, vitamin B
2, vitamin D
3,selenocarrageenan sieves respectively, mixes 10 minutes, obtain mixed powder 1, VitAVitE, nicotinic acid are sieved respectively, mix 10 minutes obtain mixed powder 2 after weighing according to the above ratio with mixed powder 1 after weighing according to the above ratio; Vitamin C is mixed 10 minutes with mixed powder 2, obtains mixed powder 3; Dextrin is sieved, mixes 10 minutes with mixed powder 3 after weighing according to aforementioned proportion and obtain mixed powder 4; To weigh mixing 10 minutes according to aforementioned proportion after Ferrous gluconate, zinc gluconate are sieved, obtain mixed powder 5, starch, calcium carbonate are sieved respectively, with mixed of mixed powder 5 10 minutes after weighing according to aforementioned proportion, obtain mixed powder 6;
(2) soft material processed: the alcoholic solution preparing 5% polyvidone, is joined in above-mentioned mixed powder 4, and obtained soft material 1, prepares the alcoholic solution of 5% polyvidone, joined in mixed powder 6, obtained soft material 2;
(3) granulate: above-mentioned soft material 1 is put into granulator and granulates, sieve to obtain wet granular 1, soft material 2 put into granulator and granulates, sieve, obtain wet granular 2;
(4) dry, granulate: the dry 4-5 hour at-50 DEG C of temperature by wet granular 1 and wet granular 2 respectively, granulate after sieving, obtains dry granule 1 and dry granule 2;
(5) mix: after dry granule 1 and dry granule 2 are mixed 30 minutes, obtain mixture;
(6) always mix: weighing after magnesium stearate according to aforementioned proportion mixes 10 minutes with said mixture, obtains total mixture;
(7) tabletting: by above-mentioned total mixture tabletting, obtains plain sheet 1g/ sheet;
(8) coating: by hypromellose 18g, Polyethylene Glycol 3 g, titanium dioxide 6 g, Pulvis Talci 3 g and pure water are mixed with film coating liquid, carry out coating, obtain Film coated tablets to plain sheet;
(9) select, pack: select qualified product and pack, 50 slices/bottle.
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| CN201310359849.3A CN104382934A (en) | 2013-08-19 | 2013-08-19 | Multivitamin tablet for pregnant women |
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| CN106667942A (en) * | 2017-03-28 | 2017-05-17 | 四川奥邦药业有限公司 | Preparation method of ferrous succinate tablet |
| CN107836670A (en) * | 2017-09-01 | 2018-03-27 | 上海拜汶医药科技有限公司 | A kind of preparation method for the composite nutrient protected and improve women ovarian function |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108347990A (en) * | 2015-10-16 | 2018-07-31 | 诺维克斯科学私人有限公司 | The stabilization composition of vitamin C and zinc metal sheet agent |
| CN106539091A (en) * | 2016-10-29 | 2017-03-29 | 芜湖市诺康生物科技有限公司 | A kind of vitamins and minerals piece and preparation method thereof |
| CN106667942A (en) * | 2017-03-28 | 2017-05-17 | 四川奥邦药业有限公司 | Preparation method of ferrous succinate tablet |
| CN107836670A (en) * | 2017-09-01 | 2018-03-27 | 上海拜汶医药科技有限公司 | A kind of preparation method for the composite nutrient protected and improve women ovarian function |
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| CN107897934A (en) * | 2017-11-16 | 2018-04-13 | 广州市健鸣春生物科技有限公司 | Prevent fetus congenital disorders, the multi-vitamins Centrum and preparation method thereof of prevention of miscarriage |
| CN110720632A (en) * | 2019-12-03 | 2020-01-24 | 吉林省红五味生物技术有限公司 | Nutrient composition for late pregnancy and preparation method and application thereof |
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| CN110839898A (en) * | 2019-12-03 | 2020-02-28 | 吉林省红五味生物技术有限公司 | Nutrient composition for early pregnancy and preparation method and application thereof |
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