CN101138570A - Multiple vitamin and mineral composition chewing tablet - Google Patents
Multiple vitamin and mineral composition chewing tablet Download PDFInfo
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- CN101138570A CN101138570A CNA2006100217911A CN200610021791A CN101138570A CN 101138570 A CN101138570 A CN 101138570A CN A2006100217911 A CNA2006100217911 A CN A2006100217911A CN 200610021791 A CN200610021791 A CN 200610021791A CN 101138570 A CN101138570 A CN 101138570A
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Abstract
The invention relates to a health food product, in particular to a chewable tablet including a variety of vitamins and minerals applicable to pregnant women and lactating mothers. The ingredients include vitamin A, vitamin D, a vitamin B<SUB>1</SUB>, vitamin E, vitamin B<SUB>2</SUB>, vitamin B<SUB>6</SUB>, vitamin C, folic acid, pantothenic acid, anicotinamide, ferrous lactate, calcium carbonate, magnesium oxide, zinc lactate, sodium selenite, sugar, lactose, cocoa, mannitol, dextrin and magnesium stearate. Due to advanced dry granulation technology and GMP scale production, the invention completely avoids the loss of vitamin in the production process and ensures sanitary quality, safety and reliability, good taste, convenient use and low price of products.
Description
Technical field
The present invention relates to a kind of health food, concrete, the present invention relates to contain the chewable tablet of multivitamin and mineral, be particularly useful for anemia of pregnant woman and wet nurse.
Background technology
There is 3,000 ten thousand baby dues every year in China, and period of fetus and infancy stage are the most critical periods of human organ formation and growth promoter.Fetus and baby have special nutritional need, and whether the nutrition in these two stages is appropriate, to having people decisive influence throughout one's life.The nutrition of fetus is all from parent, the optimal source of nutrition of baby also should be from mother in 0～6 month, the nutriture that situation has also just determined fetus and baby is taken in mother's self healthy and nutrition, has also determined all one's life of new life simultaneously to a great extent.
Gravid woman and nursing women's nutritional need and adult women have very big-difference, can satisfy the demand that some nutrition increases by increasing food intake dose, as demand to protein, fat, saccharide and energy, but the demand of vitamin and trace element is difficult to fine satisfied, as China city women's energy requirement every day be 2100Kcal, the anemia of pregnant woman is 2300Kcal every day, the demand of folic acid is then by the 400ug of every day, increase to 600ug every day, be the heat increase in demand less than 10%, the folic acid demand but increases by 50%.Only depending on increases the purpose that food intake does not reach additional enough folic acid.Women's pregnancy period lacks folic acid, greatly influence nucleic acid and the proteinic biosynthesis of fetus, and then influence the growth promoter of fetus, the even more serious consequence of folic acid deficiency is the danger that causes the fetal nerve tissue defects and increase premature labor, premature labor is the one of the main reasons of infant death, anemia of pregnant woman's zinc demand is 16.5mg every day, and the women's that grows up demand 11.5g every day, increased by 40%, can not solve by increasing food intake equally, wet nurse is respectively every day 500 and 21.5mg to the demand of folic acid and zinc, must be solved by supplementary or medicine.These differences just can not solve by increasing food-intake, must take in special supplementary and just can reach anemia of pregnant woman and the wet nurse specific (special) requirements to vitamin and mineral.
Vitamin A all has important effect to multiple histiocytic hypertrophy and differentiation in life embryo's period of development and body.It is stable that vitamin D can be kept calcium level, prevents rickets and osteomalacia.Vitamin D also has immunoregulatory effect simultaneously.
Vitamin E is an antioxidant.Polyunsaturated fatty acid in the protecting film, cytoskeleton and other proteinic intracellular nucleic acid are avoided the attack of free radical.
Vitamin C can improve body immunity and resisting fatigue.
Vitamin B complex can prevent that vitamin B1 deficiency, asthenia, inappetence, constipation, bicker disease from appearring in the anemia of pregnant woman, improves the growth of fetus nervus centralis.
The shortage of folic acid, pantothenic acid, nicotiamide can cause fetal neural tube deformity, headache, dyssomnia.
Pregnancy duration, for satisfying fetal growth and skeleton development, parent has 30 gram calcium to give fetus through placental transport approximately, and parent is badly in need of replenishing of calcium, and calcium deficiency easily causes the parent osteoporosis during this, and influential to neonatal weight.The shortage of ferrum, magnesium, selenium, zinc can cause maternal immunity power to descend.For Ji imbalance, weak, dizzy.
China's solution vitamin and mineral deficiency mainly are medicine (OTC medicine) and foodstuff supplementary at present, and the supplementary of foodstuff can't satisfy anemia of pregnant woman and wet nurse's special requirement, the OTC medicine is mainly used in the prevention and the treatment of food deficiency disease, in order to treat food deficiency disease, essential with heavy dose of, just can cure or alleviate food deficiency disease in several days or tens days so that take medicine, come to replenish required vitamin and mineral every day with so big metering medicaments for anemia of pregnant woman or wet nurse, certainly will bring the harm of excessive use, this is that to be absolutely unsafe also be extremely unadvisable to fetus and baby, therefore preferably can avoid using this type of medicine anemia of pregnant woman and wet nurse.
Though the foodstuff supplementary also has many kind listings at present, as single vitamin, trace element, compound vitamin and little living secondary element, but mainly be adult type and child form, and do not have pregnant women and wet nurse to use, vitamin that anemia of pregnant woman and wet nurse use and microelement product require high to the science of compound recipe design, general adult uses or the child uses product, be that allowance of nutrients deficiency or abuse can not cause more serious consequence, but the product that anemia of pregnant woman and wet nurse use, vitamin and mineral element are deficiencies or excessively all can bring considerable influence to fetus and baby.
Summary of the invention
The present invention is directed to anemia of pregnant woman and wet nurse specific demand, provide a kind of safe and reliable, easy to use, multivitamin that price is relatively low and mineral composition chewing tablet vitamin and trace element.
The present invention realizes the object of the invention by implementing following technical scheme:
Multivitamin and mineral composition chewing tablet is characterized in that its every material composition that contains following weight portion:
Vitamin A 200～240ug vitamin D 0.5～1.5ug vitamin B
10.3～0.5ug
Vitamin E 3.5～4.0mg vitamin B
20.3～0.5mg vitamin B
60.35～0.45mg
Vitamin C 26.5～28.2mg folic acid 120～123ug pantothenic acid 1.28～1.42mg
Nicotiamide 3.85～4.06mg ferrous lactate 3.0～4.1mg calcium carbonate 220.6～231.2mg
Magnesium oxide 80～83.5mg zinc lactate 3.2～4.2mg sodium selenite 10～12ug
White sugar 20～50mg lactose 5.5～7.0mg cocoa powder 8～10mg
Mannitol 12～15mg dextrin 5～10mg magnesium stearate 1.5～2.0mg
The preparation method of multivitamin of the present invention and mineral composition chewing tablet is: take by weighing raw material, behind the mix homogeneously, adopt dry granulation, tabletting makes the product that specification is the 2g/ sheet.
The health care of product of the present invention: replenish multivitamin and mineral.
The eating method of product of the present invention and amount: every day 2 times, each 1, suck or chew edible.
The storage practice of product of the present invention: put shady and cool dry place, the shelf-life is 24 months.
The points for attention of product of the present invention: can not replace medicine; Should not surpass recommended amounts or edible simultaneously with similar nutrient prime replenisher; Be put in unsuitable for children and touch the place.
The present invention is according to safety, this two big principle in right amount, and fully take into account the cost of product and take convenience, " non-pregnant, gestation and nursing women's the nutrient recommended intake " of " the Chinese residents diet nutrient intake (DRIs) " that product is announced according to the establishment of Chinese Soclety of Nutrition calendar year 2001 and U.S.'s food and nutrition committee 2001 announcements, and combine up-to-date scientific and technological achievement in research and China resident diet nutrient intake is prepared.
The invention has the advantages that:
1, all major ingredients, adjuvant are all the kind of regulation in " food enrichment use sanitary standard ", and be safe and reliable.
2, anemia of pregnant woman, wet nurse only need take 2 every day, can reach DRIs 1/3～2/3 between.
3, because various major ingredients have distinctive bitter taste, the present invention has improved the mouthfeel of product by adding cocoa powder and sugar, is suitable for buccal or chews.
4, compare with external supplementary, price is lower, is easy to promote and accept.
5, this product adopts advanced dry granulation technology, presses the GMP large-scale production, has avoided the loss of vitamin in the production process fully, and has guaranteed the hygienic quality of product.
The specific embodiment
Embodiment 1
Multivitamin and mineral composition chewing tablet is characterized in that its every material composition that contains following weight portion: dehydroretinol 20ug vitamin D1 ug vitamin B
10.36ug
Vitamin E 3.66mg vitamin B
20.36mg vitamin B
60.41mg
Catergen 7.6mg folic acid 121.4ug pantothenic acid 1.37mg
Nicotiamide 395mg ferrous lactate 4.1mg calcium carbonate 230.4mg
Magnesium oxide 82mg zinc lactate 3.6mg sodium selenite 11ug
White sugar 30mg lactose 6.0mg cocoa powder 9mg
Mannitol 12mg dextrin 8mg magnesium stearate 1.6mg
Preparation method: take by weighing raw material, behind the mix homogeneously, adopt dry granulation, tabletting makes the product that specification is the 2g/ sheet.
Embodiment 2
Dehydroretinol 00ug vitamin D 0.5ug vitamin B
10.4ug
Vitamin E 3.5mg vitamin B
20.4mg vitamin B
60.45mg
Catergen 6.5mg folic acid 120ug pantothenic acid 1.28mg
Nicotiamide 3.85mg ferrous lactate 3.4mg calcium carbonate 220.6mg
Magnesium oxide 80mg zinc lactate 3.2mg sodium selenite 10.0ug
White sugar 20mg lactose 5.5mg cocoa powder 10mg
Mannitol 15mg dextrin 6mg magnesium stearate 2mg
Preparation method is with embodiment 1.
Embodiment 3
Dehydroretinol 40ug vitamin D1 .5ug vitamin B
10.5ug
Vitamin E 3.5～4.0mg vitamin B
20.5mg vitamin B
60.35mg
Catergen 8.2mg folic acid 123ug pantothenic acid 1.42mg
Nicotiamide 4.06mg ferrous lactate 4.1mg calcium carbonate 231.2mg
Magnesium oxide 83.5mg zinc lactate 4.2mg sodium selenite 12ug
White sugar 50mg lactose 7.0mg cocoa powder 8mg
Mannitol 15mg dextrin 10mg magnesium stearate 1.5mg
Preparation method is with embodiment 1.
Embodiment 4 chewable tablet of the present invention with in, U.S. recommended intake relatively
Table 1
| Vitamin A ug | Vitamin D ug | Vitamin B 1 mg | Vitamin E mg | Vitamin B 2 mg | Vitamin B 6 mg | Vitamin C mg | Folic acid ug | Pantothenic acid mg | Nicotiamide mg | ||
| Chinese Soclety of Nutrition's recommended intake (intake every day) | The adult women | 700 | 5 | 1.3 | 14 | 1.2 | 1.2 | 100 | 400 | 5.0 | 13 |
| Pregnant mother | 900 | 10 | 1.5 | 14 | 1.7 | 1.9 | 130 | 600 | 6.0 | 15 | |
| Wet nurse | 1200 | 10 | 1.8 | 14 | 1.7 | 1.9 | 130 | 500 | 7.0 | 18 | |
| U.S.'s food and nutrition committee recommended intake (intake every day) | The adult women | 700 | 5 | 1.1 | 15 | 1.1 | 1.3 | 75 | 400 | 5 | 14 |
| Pregnant mother | 770 | 5 | 1.4 | 15 | 1.4 | 1.9 | 85 | 600 | 6 | 18 | |
| Wet nurse | 1300 | 5 | 1.4 | 19 | 1.6 | 2.0 | 120 | 500 | 7 | 17 | |
| Chewable tablet of the present invention (every content) | 220 | 1 | 0.36 | 3.66 | 0.36 | 0.41 | 27.6 | 121.4 | 1.37 | 3.95 | |
| Per 2 contain vitamin and account for DRIs% | Wet nurse | 37 | 20 | 4052 | 42 | 43 | 42 | 49 | 49 | 39 | 44 |
| Per 2 contain vitamin and account for DRIs% | The anemia of pregnant woman | 49 | 20 | 48 | 52 | 42 | 43 | 42 | 40 | 46 | 53 |
Table 2
| Calcium mg | Magnesium mg | Ferrum mg | Zinc mg | Selenium ug | ||
| Chinese Soclety of Nutrition's recommended intake (intake every day) | The adult women | 800 | 350 | 20 | 11.5 | 50 |
| The anemia of pregnant woman | 1000 | 400 | 25 | 16.5 | 50 | |
| Wet nurse | 1200 | 400 | 35 | 21.5 | 65 | |
| U.S.'s food and nutrition committee recommended intake (intake every day) | The adult women | 1000 | 320 | 18 | 8 | 55 |
| The anemia of pregnant woman | 1000 | 350 | 27 | 11 | 60 | |
| Wet nurse | 1000 | 310 | 29 | 12 | 70 | |
| Chewable tablet of the present invention (every content) | 230.4 | 82 | 3.4 | 3.6 | 11.0 | |
| Per 2 contain vitamin and account for DRIs% | The anemia of pregnant woman | 46 | 41 | 27 | 44 | 44 |
| Per 2 contain vitamin and account for DRIs% | Wet nurse | 38 | 41 | 19 | 33 | 34 |
Embodiment 5 hygiology index testing results
Chewable tablet of the present invention is through the check of disease prevention and control center, Sichuan Province, and its result is as follows:
Total plate count:＜10cfu/g
Coliform:＜30MPN/100g
Mycete:＜10cfu/g
Yeast:＜10cfu/g
Pathogenic bacterium (Salmonella, shigella, Hemolytic streptococcus, staphylococcus aureus): do not detect.
Embodiment 6 functional component content
| Project | Unit | Lot number | ||
| 20031201 | 20031202 | 20031203 | ||
| Calcium (in Ca) magnesium (in Mg) ferrum (in Fe) selenium (in Se) zinc (in Zn) vitamin A vitamin D folic acid vitamin E vitamin B 1Vitamin B 2 | g/100g g/100g mg/100g mg/Kg mg/100g mg/100g ug/100g mg/100g mg/100g mg/100g mg/100g | 12.14 4.15 167.6 5.52 181 11.0 59.3 6.15 187 19.0 18.4 | 12.74 4.29 193.6 5.57 179 11.4 58.3 6.13 192 20.3 18.8 | 11.86 4.16 191.9 5.60 187 11.2 59.6 6.20 189 20.7 18.2 |
| The nicotiamide vitamin B 6The pantothenic acid vitamin C | mg/100g mg/100g mg/100g g/100g | 219.7 20.3 69.7 1.38 | 218.1 20.6 70.2 1.39 | 218.2 20.4 68.5 1.39 |
Embodiment 7 large and small Mus acute oral toxicity tests
1, method
Adopt each 40 of Kunming mouse that Sichuan Province's institute of Antibiotics experimental animal room provides and SD rats respectively, male and female half and half, mice body weight 18-22 gram, animal approval card number: the real kinoplaszm 99-32 in river, rat body weight 180-220 gram, animal approval card number: the real kinoplaszm 99-30 in river.Experimental animal room is the SPF level, 23 ± 2 ℃ of temperature, relative humidity 50～60%.Large and small Mus is divided into four dosage groups respectively at random, and 10 every group, male and female half and half.Experiment by horn method establish 1.00,2.15,4.64, four dosage groups of 10.00g/Kg, animal fasting 16h, do not limit drinking-water, in morning next day rat press the unusual per os of 2.0ml/100g.bw and irritate stomach, observe poisoning symptom and the death condition of animal in 14 days, put to death animal after experiment finishes to weigh and do gross anatomy.
2, result
Do not see poisoning symptom and death thereof after the large and small Mus contamination of male and female, observe two weeks back execution animal, carry out also no abnormality seen pathological change of gross anatomy.
3, conclusion
The present invention is to the large and small Mus acute oral of male and female LD
50Be worth all greater than 10000mg/Kg the nontoxic level in true border.
Claims (3)
1. multivitamin and mineral composition chewing tablet is characterized in that its every material composition that contains following weight portion:
Vitamin A 200～240ug vitamin D 0.5～1.5ug vitamin B
10.3～0.5ug
Vitamin E 3.5～4.0mg vitamin B
20.3～0.5mg vitamin B
60.35～0.45mg
Vitamin C 26.5～28.2mg folic acid 120～123ug pantothenic acid 1.28～1.42mg
Nicotiamide 3.85～4.06mg ferrous lactate 3.0～4.1mg calcium carbonate 220.6～23 1.2mg
Magnesium oxide 80～83.5mg zinc lactate 3.2～4.2mg sodium selenite 10～12ug
White sugar 20～50mg lactose 5.5～7.0mg cocoa powder 8～10mg
Mannitol 12～15mg dextrin 5～10mg magnesium stearate 1.5～2.0mg.
2. multivitamin as claimed in claim 1 and mineral composition chewing tablet is characterized in that its every material composition that contains following weight portion:
Vitamin A 220ug vitamin D 1ug vitamin B
10.36ug
Vitamin E 3.66mg vitamin B
20.36mg vitamin B
60.41mg
Vitamin C 27.6mg folic acid 121.4ug pantothenic acid 1.37mg
Nicotiamide 395mg ferrous lactate 4.1mg calcium carbonate 230.4mg
Magnesium oxide 82mg zinc lactate 3.6mg sodium selenite 11ug
White sugar 30mg lactose 6.0mg cocoa powder 9mg
Mannitol 12mg dextrin 8mg magnesium stearate 1.6mg.
3. multivitamin as claimed in claim 1 or 2 and mineral composition chewing tablet is characterized in that preparation method is: take by weighing raw material, behind the mix homogeneously, the method that is used in is granulated, and tabletting makes the product that specification is the 2g/ sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100217911A CN101138570A (en) | 2006-09-08 | 2006-09-08 | Multiple vitamin and mineral composition chewing tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100217911A CN101138570A (en) | 2006-09-08 | 2006-09-08 | Multiple vitamin and mineral composition chewing tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101138570A true CN101138570A (en) | 2008-03-12 |
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|---|---|---|---|
| CNA2006100217911A Pending CN101138570A (en) | 2006-09-08 | 2006-09-08 | Multiple vitamin and mineral composition chewing tablet |
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Cited By (13)
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| CN102266299A (en) * | 2011-04-06 | 2011-12-07 | 广东如来药业进出口有限公司 | Composition chewing tablets for a zinc gluconate compound and preparation method thereof |
| CN102302512A (en) * | 2011-08-10 | 2012-01-04 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102512445A (en) * | 2011-12-29 | 2012-06-27 | 杭州海王生物工程有限公司 | Multivitamin mineral preparation |
| CN102578572A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Mineral and vitamin nutritional supplement |
| CN102793163A (en) * | 2012-07-20 | 2012-11-28 | 惠州市鑫福来实业发展有限公司 | Calcium-iron-zinc-selenium multivitamin chewable tablet and preparation method thereof |
| CN103300383A (en) * | 2013-06-25 | 2013-09-18 | 陕西理工学院 | Formula of tea polyphenol-containing vitamin D tablet |
| CN103349278A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Vitamin mineral tablets |
| CN104719916A (en) * | 2013-12-18 | 2015-06-24 | 无锡伟康生物科技有限公司 | Multi-vitamin chewable tablets for pregnant women |
| CN104970372A (en) * | 2014-10-27 | 2015-10-14 | 上海妈咪宝贝生物科技有限公司 | Vitamin and mineral tablets for pregnant woman and wet nurse |
| CN106176756A (en) * | 2015-04-30 | 2016-12-07 | 刘力 | The lysine five comprising chiral photo-isomerisation compound ties up medical composition and its use |
| CN110123836A (en) * | 2019-05-20 | 2019-08-16 | 昆明朗盛生物科技有限公司 | The application of calcium zinc vitamin D pantothenic acid piece |
| CN110122880A (en) * | 2019-06-19 | 2019-08-16 | 安徽康博特保健食品有限公司 | A kind of calcium and magnesium piece health food and preparation method thereof |
| CN110250520A (en) * | 2019-06-19 | 2019-09-20 | 安徽康博特保健食品有限公司 | A kind of adult type B family vitamin health food chewable tablets and preparation method thereof |
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2006
- 2006-09-08 CN CNA2006100217911A patent/CN101138570A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266299A (en) * | 2011-04-06 | 2011-12-07 | 广东如来药业进出口有限公司 | Composition chewing tablets for a zinc gluconate compound and preparation method thereof |
| CN102266299B (en) * | 2011-04-06 | 2013-02-20 | 广东如来医药进出口有限公司 | Composition chewing tablets for a zinc gluconate compound and preparation method thereof |
| CN102302512B (en) * | 2011-08-10 | 2013-10-16 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102302512A (en) * | 2011-08-10 | 2012-01-04 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102512445A (en) * | 2011-12-29 | 2012-06-27 | 杭州海王生物工程有限公司 | Multivitamin mineral preparation |
| CN102512445B (en) * | 2011-12-29 | 2014-07-09 | 杭州海王生物工程有限公司 | Multivitamin mineral preparation |
| CN102578572A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Mineral and vitamin nutritional supplement |
| CN102793163A (en) * | 2012-07-20 | 2012-11-28 | 惠州市鑫福来实业发展有限公司 | Calcium-iron-zinc-selenium multivitamin chewable tablet and preparation method thereof |
| CN103349278A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Vitamin mineral tablets |
| CN103300383A (en) * | 2013-06-25 | 2013-09-18 | 陕西理工学院 | Formula of tea polyphenol-containing vitamin D tablet |
| CN104719916A (en) * | 2013-12-18 | 2015-06-24 | 无锡伟康生物科技有限公司 | Multi-vitamin chewable tablets for pregnant women |
| CN104970372A (en) * | 2014-10-27 | 2015-10-14 | 上海妈咪宝贝生物科技有限公司 | Vitamin and mineral tablets for pregnant woman and wet nurse |
| CN106176756A (en) * | 2015-04-30 | 2016-12-07 | 刘力 | The lysine five comprising chiral photo-isomerisation compound ties up medical composition and its use |
| CN110123836A (en) * | 2019-05-20 | 2019-08-16 | 昆明朗盛生物科技有限公司 | The application of calcium zinc vitamin D pantothenic acid piece |
| CN110122880A (en) * | 2019-06-19 | 2019-08-16 | 安徽康博特保健食品有限公司 | A kind of calcium and magnesium piece health food and preparation method thereof |
| CN110250520A (en) * | 2019-06-19 | 2019-09-20 | 安徽康博特保健食品有限公司 | A kind of adult type B family vitamin health food chewable tablets and preparation method thereof |
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Application publication date: 20080312 |