CN102302512A - Multi-vitamin mineral tablet - Google Patents
Multi-vitamin mineral tablet Download PDFInfo
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- CN102302512A CN102302512A CN201110228024A CN201110228024A CN102302512A CN 102302512 A CN102302512 A CN 102302512A CN 201110228024 A CN201110228024 A CN 201110228024A CN 201110228024 A CN201110228024 A CN 201110228024A CN 102302512 A CN102302512 A CN 102302512A
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Abstract
The invention relates to the field of medicine, and discloses a multi-vitamin mineral tablet. The multi-vitamin mineral tablet is composed of a vitamin layer, an isolation layer and a mineral layer, wherein the isolation layer is positioned between the vitamin layer and the mineral layer, and has the thickness of 1-2mm; and the vitamin layer contains vitamin C. According to the invention, vitamin and mineral elements are isolated effectively by utilizing the isolation layer between the vitamin layer and the mineral layer, vitamin C is protected effectively, the use amount and variety of the auxiliary materials are not required to be increased additionally, and the production cost is lower.
Description
Technical field
The present invention relates to field of medicaments, relate to a kind of multidimensional mineral tablet in particular.
Background technology
Vitamin and mineral element are to keep human body normal physiological activity and the necessary nutrient of growth promoter, have the effect of the vision safeguarded, promotion growth promoter like vitamin A; Vitamin C has effects such as treatment vitamin C deficiency, antioxidation, anti-cancer; Calcium constituent is an indispensable element of keeping the skeleton growth; Ferrum element has the prevention anemia, promotes the effect of Plumbum removing.The national nutrition survey of announcing according to Chinese Soclety of Nutrition shows China urban and rural residents famine vitamin A, vitamin B
2And calcium, B generally is deficient in vitamin
1, vitamin B
6With vitamin C etc., wherein, the middle-aged and elderly people C that is deficient in vitamin is more serious.In addition, the also general zinc deficiency of child, the general iron deficiency of women.
For replenish these nutrients comprehensively, usually multivitamin and several mineral materials are added as raw material simultaneously, be made into the product that contains multivitamin and mineral, be called for short the multidimensional mineral products, like multidimensional mineral tablet, multidimensional mineral grain etc.The advantage of this series products is through once taking, just can reaching the effect that replenishes multivitamin and mineral simultaneously, and is convenient convenient, receives liking of more and more consumers.
At present, the process of making multidimensional mineral tablet or multidimensional mineral grain is that multivitamin and multi mineral raw material and molding adjuvant etc. are mixed together, granulate, and after drying, makes the multidimensional mineral grain, or carries out tabletting again and do slabbing.In addition, also have raw material such as multivitamin and several mineral materials and adjuvant are mixed with soybean oil, add suspending agent and make multidimensional mineral soft capsule.
But there is certain deficiency in the product that adopts above-mentioned process to process, because chemical property reason own, some vitamin contacts with mineral and can react, thereby the content of vitamin is reduced, and then causes product efficacy to reduce.Wherein, loss is vitamin C the most significantly because vitamin C has very strong reproducibility, very easily and mineral element ions such as ferrum, copper, selenium react and oxidized, thereby reduce ascorbic content.
In order to make vitamin C can reach effect institute expense, the means that adopt have three kinds at present: (1) is through adding excessive vitamin C etc. to offset ascorbic loss; (2) earlier vitamin C is carried out embedding, again with granulate after other raw materials mix, make product; (3) adopt ascorbic derivant (like sodium L-ascorbate-2-phosphate, sodium ascorbate, calcium ascorbate, vitamin C potassium and Magnesium L-Asacorbic Acid 2-O-Phosphate etc.) to replace vitamin C to use.
But; These three kinds of methods also exist certain technical disadvantages; At first be to add excessive vitamin C; Though can increase Vitamin C content in the product; But ascorbic content is still wayward in the product; The vitamin C loss is still very big, also can increase production cost greatly through adding excessive vitamin C in addition;
Next is that vitamin C is carried out embedding, can isolate contacting of vitamin C and mineral element on this theoretical method.But vitamin C is carried out embedding; Make in the process of product with other raw materials mix after granulating, the extruding of tablet machine during owing to compression molding can be squeezed the vitamin C granules compacting of embedding broken; Still vitamin C can be exposed under the mineral environment, cause loss largely;
Be to adopt ascorbic derivant at last; Though it is stable slightly that more ascorbic derivants are compared vitamin; But sodium L-ascorbate-2-phosphate wherein; Sodium ascorbate; Calcium ascorbate; Vitamin C potassium still has good reproducibility; Can react with mineral elements such as ferrum equally; And reduction content; Though Magnesium L-Asacorbic Acid 2-O-Phosphate character very stable not can with the reaction of mineral element such as ferrum; But in vivo must be through the effect of phosphate; The vitamin C enzymolysis is dissociated; The ascorbic physiological function of competence exertion, this has limited human body and has absorbed ascorbic.In addition, ascorbic content is relatively low in the ascorbic derivant, and costs an arm and a leg, and increases production cost easily.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of multidimensional mineral tablet, make this multidimensional mineral tablet can reduce ascorbic loss.
For realizing above-mentioned purpose, the present invention provides following technical scheme:
A kind of multidimensional mineral tablet is made up of vitamin layer, isolation layer and mineral layer, and said isolation layer is between vitamin layer and mineral layer, and thickness is 1-2mm, and said vitamin layer comprises vitamin C.
After granulating respectively, multivitamin and the several mineral materials of the present invention through will comprising vitamin C carry out special tabletting; The centre separates with isolation layer; Process the three-layer tablet form; In the multidimensional mineral three-layer tablet of making; Have an isolation layer between multivitamin layer and the multi mineral prime element layer, rather than directly contact, vitamin C can not contact with mineral element fully like this; Can not produce loss, protect ascorbic effect thereby play because of reacting.
Thinner for fear of isolation layer; In the tabletting process, make vitamin layer and mineral layer contact surface occur; Then the situation that the vitamin C loss occurs; Isolation layer thickness according to the invention is 1-2mm; Be preferably 1.5mm, be made up of in maltodextrin, white sugar, mannitol, starch and the microcrystalline Cellulose one or more, these several materials are the medicine typical additives; Concrete ratio does not limit, and can confirm according to the art technology experience.
Vitamin layer according to the invention and mineral layer select for use human body required and easy shortage commonly used nutrient and additive be raw material, wherein, in weight portion, said vitamin layer is by 0.2-2 weight portion vitamin A, 0.3-3 weight portion vitamin B
1, 0.3-3 weight portion vitamin B
2, 0.25-2.5 weight portion vitamin B
6, 0.6-6 weight portion vitamin B
12, 0.1-1 weight portion folic acid, 50-200 weight portion vitamin C, 0.002-0.02 weight portion vitamin D, 2-20 weight portion vitamin E, 100-400 weight portion starch, 100-400 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate constitute; In weight portion, said mineral layer is made up of 50-200 weight portion calcium, 2-20 weight portion ferrum, 2-20 weight portion zinc, 0.008-0.08 weight portion selenium, 140-560 weight portion starch, 80-320 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate.
The present invention also provides a kind of method for preparing of multidimensional mineral tablet; To include ascorbic vitamin layer raw material and mineral layer raw material respectively after mixing, make soft material, granulation, drying, granulate, total mixing; Obtain vitamin layer granule and mineral layer granule; Carrying out three laminate with the isolation layer raw material then promptly gets; Said isolation layer is between vitamin layer and mineral layer, and thickness is 1-2mm.
Wherein, said isolation layer thickness is preferably 1.5mm, is made up of in maltodextrin, white sugar, mannitol, starch and the microcrystalline Cellulose one or more.
Vitamin layer raw material according to the invention and mineral layer raw material comprise multivitamin, mineral and typical additives.Wherein, said vitamin layer raw material is in weight portion, by 0.2-2 weight portion vitamin A, 0.3-3 weight portion vitamin B
1, 0.3-3 weight portion vitamin B
2, 0.25-2.5 weight portion vitamin B
6, 0.6-6 weight portion vitamin B
12, 0.1-1 weight portion folic acid, 50-200 weight portion vitamin C, 0.002-0.02 weight portion vitamin D, 2-20 weight portion vitamin E, 100-400 weight portion starch, 100-400 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate constitute.
Said mineral layer raw material is made up of 50-200 weight portion calcium, 2-20 weight portion ferrum, 2-20 weight portion zinc, 0.008-0.08 weight portion selenium, 140-560 weight portion starch, 80-320 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate in weight portion.
The present invention adds the minerals and vitamins raw material of same amount; Adopt the direct mixing granulation tablet forming technique of vitamin and mineral respectively; Vitamin and mineral are separately granulated and are always mixed the back tablet forming technique; And employing embedding VC granule; The multidimensional mineral products of VC derivant (VC calcium and VC cetylate) prepared; Compare with multidimensional mineral tablet according to the invention; The result is presented in the equivalent environment and places the identical time; The ascorbic loss amount of multidimensional mineral tablet according to the invention is below 3.5%; And the loss of the vitamin C loss amount of the multidimensional mineral products of other prepared is more serious, is several times or tens times of multidimensional mineral tablet according to the invention.
Can know by above technical scheme; Multidimensional mineral tablet according to the invention utilizes the isolation layer between mineral layer and the vitamin layer, has effectively isolated vitamin and mineral element, has protected vitamin C; And used supplementary material consumption and kind do not need extra increase, and production cost is lower.
The specific embodiment
The invention discloses a kind of multidimensional mineral tablet, those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as and are included in the present invention.Multidimensional mineral tablet according to the invention is described through preferred embodiment; The related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use technology of the present invention.
Below in conjunction with embodiment, further set forth the present invention.
Embodiment 1:
1, the vitamin layer is granulated
0.3 weight portion vitamin B of 80 mesh sieves will be crossed
1, 0.3 weight portion vitamin B
2, 0.25 weight portion vitamin B
6, 0.6 weight portion vitamin B
12, 0.1 weight portion folic acid, 50 weight portion vitamin C powder mix homogeneously, with 100 weight portion white sugars, 100 weight portion starch and the 50 weight portion maltodextrin mixings of crossing 80 eye mesh screens, obtain vitamin layer material again;
In vitamin layer material, add 20% alcoholic solution, the limit edged stirs, and processes soft material; Then soft material is granulated through 16 eye mesh screens; Process wet granular and dry; Dried granule is crossed 16 eye mesh screens carry out granulate; Mix with 0.2 weight portion vitamin A, 0.002 weight portion vitamin D and 2 weight portion vitamin E particle powders and 1.3 weight portion magnesium stearate then; Obtain the vitamin layer and always mix granule, subsequent use.
2, the mineral layer is granulated
To cross 50 weight portion calcium, 2 weight portion ferrum, 2 weight portion zinc, the 0.008 weight portion selenium mix homogeneously of 80 mesh sieves, with 80 weight portion white sugars, 140 weight portion starch and the 50 weight portion maltodextrin mixings of crossing 80 eye mesh screens, obtain mineral layer material again;
In mineral layer material, add 20% alcoholic solution, the limit edged stirs, and processes soft material; Then soft material is granulated through 16 eye mesh screens, process wet granular and dry, dried granule is crossed 16 eye mesh screens carry out granulate, mix with 1.3 weight portion magnesium stearate then, obtain the mineral layer and always mix granule, subsequent use.
3, tabletting
With vitamin layer granule and mineral layer granule; Send into multilamellar tablet machine tabletting with the isolation layer raw material (100 weight portion white sugars and 50 weight portion maltodextrins) of crossing 80 mesh sieve mix homogeneously and get multidimensional mineral tablet; Said isolation layer thickness is 1mm, is positioned in the middle of vitamin layer and the mineral layer.
Embodiment 2:
1, the vitamin layer is granulated
1.6 weight portion vitamin Bs of 90 mesh sieves will be crossed
1, 1.6 weight portion vitamin Bs
2, 1.4 weight portion vitamin Bs
6, 3.3 weight portion vitamin Bs
12, 0.6 weight portion folic acid, 125 weight portion vitamin C powder mix homogeneously, with 250 weight portion white sugars, 250 weight portion starch and the 125 weight portion maltodextrin mixings of crossing 90 eye mesh screens, obtain vitamin layer material again;
In vitamin layer material, add purified water, the limit edged stirs, and processes soft material; Then soft material is granulated through 20 eye mesh screens; Process wet granular and dry; Dried granule is crossed 20 eye mesh screens carry out granulate; Mix with 1.1 weight portion vitamin A, 0.011 weight portion vitamin D and 11 weight portion vitamin E particle powders and 3.9 weight portion magnesium stearate then; Obtain the vitamin layer and always mix granule, subsequent use.
2, the mineral layer is granulated
To cross 125 weight portion calcium, 11 weight portion ferrum, 11 weight portion zinc, the 0.044 weight portion selenium mix homogeneously of 90 mesh sieves, with 350 weight portion white sugars, 200 weight portion starch and the 125 weight portion maltodextrin mixings of crossing 90 eye mesh screens, obtain mineral layer material again;
In mineral layer material, add purified water, the limit edged stirs, and processes soft material; Then soft material is granulated through 20 eye mesh screens, process wet granular and dry, dried granule is crossed 20 eye mesh screens carry out granulate, mix with 3.9 weight portion magnesium stearate then, obtain the mineral layer and always mix granule, subsequent use.
3, tabletting
With vitamin layer granule and mineral layer granule; Send into multilamellar tablet machine tabletting with the isolation layer raw material (100 weight portion starch and 50 weight portion mannitol) of crossing 90 mesh sieve mix homogeneously and get multidimensional mineral tablet; Said isolation layer thickness is 1mm, is positioned in the middle of vitamin layer and the mineral layer.
Embodiment 3:
1, the vitamin layer is granulated
3 weight portion vitamin Bs of 100 mesh sieves will be crossed
1, 3 weight portion vitamin Bs
2, 2.5 weight portion vitamin Bs
6, 6 weight portion vitamin Bs
12, 1 weight portion folic acid, 200 weight portion vitamin C powder mix homogeneously, with 400 weight portion white sugars, 400 weight portion starch and the 200 weight portion maltodextrin mixings of crossing 100 eye mesh screens, obtain vitamin layer material again;
In vitamin layer material, add 40% alcoholic solution, the limit edged stirs, and processes soft material; Then soft material is granulated through 24 eye mesh screens; Process wet granular and dry; Dried granule is crossed 24 eye mesh screens carry out granulate; Mix with 2 weight portion vitamin A, 0.02 weight portion vitamin D and 20 weight portion vitamin E particle powders and 6.5 weight portion magnesium stearate then; Obtain the vitamin layer and always mix granule, subsequent use.
2, the mineral layer is granulated
200 weight portion calcium, 20 weight portion ferrum, 20 weight portion zinc, the 0.08 weight portion selenium mix homogeneously of 100 mesh sieves will be crossed; With 560 weight portion white sugars, 320 weight portion starch and the 200 weight portion maltodextrin mixings of crossing 100 eye mesh screens, obtain mineral layer material again;
In mineral layer material, add 40% alcoholic solution, the limit edged stirs, and processes soft material; Then soft material is granulated through 24 eye mesh screens, process wet granular and dry, dried granule is crossed 24 eye mesh screens carry out granulate, mix with 6.5 weight portion magnesium stearate then, obtain the mineral layer and always mix granule, subsequent use.
3, tabletting
With vitamin layer granule and mineral layer granule; Send into multilamellar tablet machine tabletting with the isolation layer raw material (100 weight portion white sugars and 50 weight portion maltodextrins) of crossing 100 mesh sieve mix homogeneously and get multidimensional mineral tablet; Said isolation layer thickness is 1mm, is positioned in the middle of vitamin layer and the mineral layer.
Embodiment 4:
Add the minerals and vitamins raw material of same amount; Adopt the direct mixing granulation tablet forming technique of vitamin and mineral, vitamin and mineral separately to granulate respectively and always mix the back tablet forming technique; And the multidimensional mineral products that adopts embedding VC granule, VC derivant (VC calcium and VC cetylate) prepared; Compare with the multidimensional mineral tablet of embodiment 2 preparations; Contrast test is an accelerated test, and the result sees table 1.
Table 1 change of vitamin C comparing result
Annotate: the accelerated test temperature is 40 ± 2 ℃, relative humidity 70 ± 5%.
Can know by table 1; Multidimensional mineral tablet according to the invention can effectively reduce ascorbic loss; And increase along with natural law; This advantage is all the more obvious; And the product of other process preparations; Ascorbic loss amount is very remarkable, is several times or tens times of multidimensional mineral tablet according to the invention.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; Can also make some improvement and retouching, these improvement and retouching also should be considered as protection scope of the present invention.
Claims (10)
1. a multidimensional mineral tablet is characterized in that, is made up of vitamin layer, isolation layer and mineral layer, and said isolation layer is between vitamin layer and mineral layer, and thickness is 1-2mm, and said vitamin layer comprises vitamin C.
2. according to the said multidimensional mineral of claim 1 tablet, it is characterized in that said isolation layer thickness is 1.5mm.
3. according to the said multidimensional mineral of claim 1 tablet, it is characterized in that said isolation layer is made up of in maltodextrin, white sugar, mannitol, starch and the microcrystalline Cellulose one or more.
4. according to the said multidimensional mineral of claim 1 tablet, it is characterized in that in weight portion, said vitamin layer is by 0.2-2 weight portion vitamin A, 0.3-3 weight portion vitamin B
1, 0.3-3 weight portion vitamin B
2, 0.25-2.5 weight portion vitamin B
6, 0.6-6 weight portion vitamin B
12, 0.1-1 weight portion folic acid, 50-200 weight portion vitamin C, 0.002-0.02 weight portion vitamin D, 2-20 weight portion vitamin E, 100-400 weight portion starch, 100-400 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate constitute.
5. according to the said multidimensional mineral of claim 1 tablet; It is characterized in that; In weight portion, said mineral layer is made up of 50-200 weight portion calcium, 2-20 weight portion ferrum, 2-20 weight portion zinc, 0.008-0.08 weight portion selenium, 140-560 weight portion starch, 80-320 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate.
6. the method for preparing of a multidimensional mineral tablet; It is characterized in that; To include ascorbic vitamin layer raw material and mineral layer raw material respectively after mixing, make soft material, granulation, drying, granulate, total mixing; Obtain vitamin layer granule and mineral layer granule; Carrying out three laminate with the isolation layer raw material then promptly gets; Said isolation layer is between vitamin layer and mineral layer, and thickness is 1-2mm.
7. according to the said method for preparing of claim 6, it is characterized in that said isolation layer thickness is 1.5mm.
8. according to the said method for preparing of claim 6, it is characterized in that said isolation layer raw material is made up of in maltodextrin, white sugar, mannitol, starch and the microcrystalline Cellulose one or more.
9. according to the said method for preparing of claim 6, it is characterized in that in weight portion, said vitamin layer raw material is by 0.2-2 weight portion vitamin A, 0.3-3 weight portion vitamin B
1, 0.3-3 weight portion vitamin B
2, 0.25-2.5 weight portion vitamin B
6, 0.6-6 weight portion vitamin B
12, 0.1-1 weight portion folic acid, 50-200 weight portion vitamin C, 0.002-0.02 weight portion vitamin D, 2-20 weight portion vitamin E, 100-400 weight portion starch, 100-400 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate constitute.
10. according to the said method for preparing of claim 6; It is characterized in that; In weight portion, said mineral layer raw material is made up of 50-200 weight portion calcium, 2-20 weight portion ferrum, 2-20 weight portion zinc, 0.008-0.08 weight portion selenium, 140-560 weight portion starch, 80-320 weight portion white sugar, 50-200 weight portion maltodextrin and 1.3-6.5 weight portion magnesium stearate.
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| CN 201110228024 CN102302512B (en) | 2011-08-10 | 2011-08-10 | Multi-vitamin mineral tablet |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103349278A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Vitamin mineral tablets |
| CN110327303A (en) * | 2019-08-15 | 2019-10-15 | 威海百合生物技术股份有限公司 | A kind of iron vitamin C tablet and preparation method thereof |
| CN110403945A (en) * | 2018-04-28 | 2019-11-05 | 上海泽生科技开发股份有限公司 | Promote the compound vitamin composition and preparation method thereof of gastronintestinal system power |
| CN113180245A (en) * | 2021-06-07 | 2021-07-30 | 湖北人缘堂医药生物工程有限公司 | Production method of multi-vitamin mineral tablets |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103349278A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Vitamin mineral tablets |
| CN110403945A (en) * | 2018-04-28 | 2019-11-05 | 上海泽生科技开发股份有限公司 | Promote the compound vitamin composition and preparation method thereof of gastronintestinal system power |
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| CN113180245A (en) * | 2021-06-07 | 2021-07-30 | 湖北人缘堂医药生物工程有限公司 | Production method of multi-vitamin mineral tablets |
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