CN103655639B - A kind of spirulina tablet and preparation method thereof - Google Patents
A kind of spirulina tablet and preparation method thereof Download PDFInfo
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- CN103655639B CN103655639B CN201310661998.5A CN201310661998A CN103655639B CN 103655639 B CN103655639 B CN 103655639B CN 201310661998 A CN201310661998 A CN 201310661998A CN 103655639 B CN103655639 B CN 103655639B
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Abstract
The present invention relates to field of medicaments, disclose a kind of spirulina tablet.Receive and magnesium stearate composition primarily of Spirulina powder, oligomeric xylose, isomaltulose, hydroxypropyl emthylcellulose, polyethylene glycol 6000, carboxymethyl starch, to account for tablet weight percentages, described each constituent content: 75-88% Spirulina powder, 4-10% oligomeric xylose, 4-10% isomaltulose, 0.5-2% hydroxypropyl emthylcellulose, 0.5-1% polyethylene glycol 6000,2-5% carboxymethyl starch are received, 0.2-1% magnesium stearate.The present invention utilizes the hydrophilic of oligomeric xylose, isomaltulose, polyethylene glycol 6000, and optimizes preparation method, and emphasis solves the underproof problem of the ubiquitous slaking index of spirulina tablet product.In addition, product of the present invention has any surface finish, steady quality, be convenient for carrying and the advantage such as to take, and has the function increasing immunity.
Description
Technical field
The present invention relates to field of medicaments, relate to a kind of spirulina tablet and preparation method thereof in particular.
Background technology
Spirulina is the Trentepohlia such as protokaryon such as many cells such as a class low grade of Cyanophyta Oscillatoriales Oscillariaceae Spirullina.There is in spirulina abundant nutritive value: carbohydrate content is moderate, abundant species; Protein content is high, and aminoacid composition rationally; Unsaturated fatty acid accounting is high, containing the gamma-Linolenic acid that other plant does not have; Content of mineral substances is comprehensive, and vitamin content enriches.The distinctive health-care effect of spirulina and biological activity have received biology, the extensive concern of threpsology and medical circle and exploitation.Based on the search time comparatively morning to spirulina breeding and algae powder, China has become the big producing country of world wide internal coiling algae powder at present.
But Spirulina powder itself has unjoyful mouthfeel and is stained with stickiness, take quite inconvenient.Conveniently spirulina is taken better by consumer, and Spirulina powder is made tablet as production marketing by most of enterprise.
Chinese patent application 96102203.5 discloses a kind of spirulina tablet, with the spirulina of 75-85% for major ingredient, be equipped with the carboxymethyl starch sodium of 7.5-12% or starch or Icing Sugar or dextrin, the microcrystalline Cellulose of 2-4%, the hydroxypropyl cellulose of 2-4%, polyvinylpyrrolidone 1-2%, adds magnesium stearate 0.5-1%, then add appropriate wetting agent adjuvant make soft material and granule compacting form tablet.
Chinese patent application 200510096483.0 discloses a kind of tablet spirulina spp for invigorating yang and preparation method thereof, after being taken in proportion by spirulina 80-87.5%, Herba Cynomorii frost 10-15%, cellulose 1.0-2.0%, silica 1 .25-2.5%, magnesium stearate 0.25-0.5%; After abundant mix homogeneously crosses 40-60 mesh sieve, adopt rotary tablet machine, dry powder straight forming method is pressed into tablet.
Chinese patent application 200610020142.X discloses a kind of spirulina chewing tablets and preparation method thereof, is to coordinate with two or more raw materials in dextrin, microcrystalline Cellulose, mannitol, xylitol, aspartame, glycyrrhizin, powdered flavor, micropowder silica gel, magnesium stearate with spirulina to make.
Chinese patent application 200810233606.4 discloses a kind of spiral algae sheet and preparation method thereof, take spirulina as raw material, dehydration, vacuum spray drying, the technique such as to sieve after filtration, then after being aided with micropowder silica gel, magnesium stearate, through mixing, tabletting is refining forms.
Chinese patent application 200910018851.8 discloses a kind of spirulina tablet, Spirulina powder, micropowder silica gel, dextrine powder is adopted to be that raw material is prepared from, raw material composition is by weight percentage: Spirulina powder 73%-80%, micropowder silica gel 10%-15%, dextrine powder 6%-15%, it can obtain by following method: mixing, stirring, be finally pressed into tablet.
Chinese patent application 201010541210.3 discloses a kind of spiral algae sheet and preparation method thereof.Raw material weight proportioning is: Spirulina powder 60 ~ 85%, polyvinylpolypyrrolidone 5-15%, acrylic resin III 0.5-3%, silica 1-3.5%, magnesium stearate 0.4-0.6%, micropowder silica gel 5-12%, microcrystalline Cellulose 3-6%.After Spirulina powder, polyvinylpolypyrrolidone are crossed 80 mesh sieve mix homogeneously, granulate with the acrylic resin III alcoholic solution of mass percentage concentration, after particle drying, add tabletted after the silicon dioxide of 1-3.5%, the hard magnesium of magnesium stearate, micropowder silica gel, microcrystalline Cellulose mix homogeneously.
All there is such defect in above-mentioned spirulina tablet: due to spirulina run into water after can occur swelling, the surface of spiral algae sheet is caused to form one deck water barrier, make water cannot penetrate into tablet inside, finally cause tablet disintegration times (correlated quality according to state food pharmaceuticals administration general bureau specifies: the disintegration time of tablet should be less than or equal to 60 minutes) against regulation.The underproof spiral algae sheet of disintegrate not only can extend product disintegrate release time in vivo, affects the absorption of body for product nutritional labeling, but also can due to cannot disintegrate and then cause the stomach discomfort sense of part user.
In order to address this problem, the means adopted at present are mainly: by reducing the addition (usually below 50%) of Spirulina powder, thus reduce the swelling action of spirulina.But, the heavily internal strength effective component content minimizing of unit sheet can be caused like this, thus the spiral algae sheet making consumer need to take more just can reach the effect of nourishing healthy.
Summary of the invention
In view of this, under having the object of the present invention is to provide a kind of prerequisite high at effective ingredient Spirulina powder content, can significantly shorten tablet disintegration time and be conducive to nutritional labeling absorb spirulina tablet, to solve the underproof problem of the ubiquitous slaking index of existing spirulina tablet product.
For achieving the above object, the invention provides following technical scheme:
A kind of spirulina tablet, it is characterized in that, described spirulina tablet forms primarily of Spirulina powder, oligomeric xylose, isomaltulose, hydroxypropyl emthylcellulose, polyethylene glycol 6000, carboxymethyl starch sodium and magnesium stearate, to account for tablet weight percentages, described each constituent content: 75-88% Spirulina powder, 4-10% oligomeric xylose, 4-10% isomaltulose, 0.5-2% hydroxypropyl emthylcellulose, 0.5-1% polyethylene glycol 6000,2-5% carboxymethyl starch sodium, 0.2-1% magnesium stearate.
Further, to account for tablet weight percentages, described each constituent content: 80-82% Spirulina powder, 5-7% oligomeric xylose, 5-7% isomaltulose, 0.8-1.5% hydroxypropyl emthylcellulose, 0.5-0.7% polyethylene glycol 6000,3-4% carboxymethyl starch sodium, 0.4-0.8% magnesium stearate.
The present invention selects suitable each component supplementary material, take Spirulina powder as primary raw material, with oligomeric xylose, isomaltulose and polyethylene glycol 6000 are hydrophilic component, take carboxymethyl starch sodium as disintegrating agent, proportioning is scientific and reasonable, when spiral algae sheet is under aqueous systems condition, oligomeric xylose, isomaltulose and polyethylene glycol 6000 can absorb water rapidly dissolving, penetrating passage is formed from tablet surface to inside, make outside water can enter into tablet inside, after tablet surface has water to inside, tablet disperses further under the effect of disintegrating agent carboxymethyl base Starch Sodium, disintegrate.Therefore, at short notice, spirulina tablet can complete disintegrate.Spirulina tablet of the present invention under the prerequisite that effective ingredient Spirulina powder content is high, can significantly shorten tablet disintegration time and be conducive to nutritional labeling absorb spirulina tablet, solve the underproof problem of the ubiquitous slaking index of existing spirulina tablet product.
Present invention also offers the preparation method of above-mentioned spirulina tablet, it is characterized in that, mainly comprise the following steps:
(1) raw material sieves: Spirulina powder, oligomeric xylose, isomaltulose are crossed 80-100 mesh sieve;
(2) soft material processed: Spirulina powder, oligomeric xylose, isomaltulose mix homogeneously after step (1) being processed, add wetting agent soft material; Described wetting agent is the hydroxypropyl emthylcellulose alcoholic solution of 30-50% dissolve with ethanol by concentration;
(3) wet granular processed: soft material prepared by step (2) is crossed 30-40 eye mesh screen and makes granule;
(4) dry: the soft material that step (3) is obtained carries out drying, and baking temperature is 50-70 DEG C, and the time is 20-120min, and being dried to pellet moisture is 2-4%;
(5) granulate: the dry granule that step (4) is obtained crosses 30-40 mesh sieve;
(6) always mix: in the dry granule of step (5) gained, add polyethylene glycol 6000, carboxymethyl starch sodium, magnesium stearate always mix;
(7) total mixed granule step (6) obtained carries out tabletting, inspection, packaging.
Beneficial effect
Spirulina tablet of the present invention has following technological merit and progress: (1) utilizes suitable each component supplementary material, and the production technology preparation of improvement, each component is uniformly distributed in tablet finished product, makes tablet from surface to inside, all be distributed with polyethylene glycol 6000, oligomeric xylose and the isomaltulose with hydrophilic interaction; (2) when spiral algae sheet is under aqueous systems condition, Macrogol 600, oligomeric xylose and isomaltulose can absorb water rapidly dissolving, form penetrating passage, make outside water can enter into tablet inside from tablet surface to inside; (3) after tablet surface has water to inside, tablet disperses further under the effect of carboxymethyl starch sodium, disintegrate.Finally solve the underproof problem of the ubiquitous slaking index of spirulina tablet product.In addition, product of the present invention has any surface finish, steady quality, be convenient for carrying and the advantage such as to take, and has the function increasing immunity.
In addition, wetting agent adopts the advantage of 30-50% dissolve with ethanol hydroxypropyl emthylcellulose: by low-concentration ethanol and water dissolution hydroxypropyl emthylcellulose speed comparatively slow (needing at least several hours) under (1) general case, and 30-50% ethanol can rapid solution hydroxypropyl emthylcellulose; (2) adopt the dissolve with ethanol of 30-50%, part water can also be brought in soft material process processed, can accomplish to draw wet effect, Intensified support effect, improve finished tablet hardness and friability index.
Detailed description of the invention
The invention discloses a kind of spirulina tablet and preparation method, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Multi-vitamin mineral tablet of the present invention is described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
Below in conjunction with embodiment, set forth the present invention further.
Embodiment 1:
(1) raw material sieves: by accounting for 75% Spirulina powder of tablet quality ratio, 8% oligomeric xylose, 10% isomaltulose cross 80 mesh sieves.
(2) soft material processed: Spirulina powder, oligomeric xylose, isomaltulose soft material after (1) is processed, wetting agent selects concentration to be 30% dissolve with ethanol hydroxypropyl emthylcellulose, makes the hydroxypropyl emthylcellulose alcoholic solution that mass concentration is 0.5%.
(3) wet granular processed: soft material prepared by (2) is crossed 30 eye mesh screens and makes granule.
(4) dry: the soft material that (3) are obtained carries out drying, and temperature is 60 DEG C, and the time is 60min, and being dried to pellet moisture is 2-4%.
(5) granulate: the dry granule that (4) are obtained crosses 30 mesh sieves.
(6) always mix: add 0.8% polyethylene glycol 6000 in the dry granule of (5) after sizing, 5% carboxymethyl starch sodium, 0.2% magnesium stearate always mix.
(7) the total mixed granule (6) obtained carries out tabletting, inspection, packaging.
Embodiment 2:
(1) raw material sieves: by accounting for 82% Spirulina powder of tablet quality ratio, 6% oligomeric xylose, 6% isomaltulose cross 80 mesh sieves.
(2) soft material processed: Spirulina powder, oligomeric xylose, isomaltulose soft material after (1) is processed, wetting agent selects concentration to be 40% dissolve with ethanol hydroxypropyl emthylcellulose, makes the hydroxypropyl emthylcellulose alcoholic solution that mass concentration is 0.5%.
(3) wet granular processed: soft material prepared by (2) is crossed 30 eye mesh screens and makes granule.
(4) dry: the soft material that (3) are obtained carries out drying, and temperature is 65 DEG C, and the time is 50min, and being dried to pellet moisture is 2-4%.
(5) granulate: the dry granule that (4) are obtained crosses 30 mesh sieves.
(6) always mix: add 0.5% polyethylene glycol 6000 in the dry granule of (5) after sizing, 3% carboxymethyl starch sodium, 0.5% magnesium stearate always mix.
(7) the total mixed granule (6) obtained carries out tabletting, inspection, packaging.
Embodiment 3:
(1) raw material sieves: by accounting for 88% Spirulina powder of tablet quality ratio, 4% oligomeric xylose, 4% isomaltulose cross 80 mesh sieves.
(2) soft material processed: Spirulina powder, oligomeric xylose, isomaltulose soft material after (1) is processed, wetting agent selects concentration to be 30% dissolve with ethanol hydroxypropyl emthylcellulose, makes the hydroxypropyl emthylcellulose alcoholic solution that mass concentration is 0.5%.
(3) wet granular processed: soft material prepared by (2) is crossed 30 eye mesh screens and makes granule.
(4) dry: the soft material that (3) are obtained carries out drying, and temperature is 60 DEG C, and the time is 60min, and being dried to pellet moisture is 2-4%.
(5) granulate: the dry granule that (4) are obtained crosses 30 mesh sieves.
(6) always mix: add 0.5% polyethylene glycol 6000 in the dry granule of (5) after sizing, 2% carboxymethyl starch sodium, 1% magnesium stearate always mix.
(7) the total mixed granule (6) obtained carries out tabletting, inspection, packaging.
Embodiment 4
The finished product of case study on implementation 1-3 and two spiral algae sheet bought on the market are carried out accelerated test, and detect slaking index situation of change, result is as follows:
Slaking index testing result under table 1 accelerated test
Note: accelerated test temperature is 40 ± 2 DEG C, relative humidity 70 ± 5%.
As shown in Table 1, spirulina tablet of the present invention can still keep good disintegrate data at 90 days under accelerated test condition, compared to commercially available prod, have obvious progress.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (3)
1. a spirulina tablet, it is characterized in that, described spirulina tablet is made up of Spirulina powder, oligomeric xylose, isomaltulose, hydroxypropyl emthylcellulose, polyethylene glycol 6000, carboxymethyl starch sodium and magnesium stearate, to account for tablet weight percentages, described each constituent content: 75-88% Spirulina powder, 4-10% oligomeric xylose, 4-10% isomaltulose, 0.5-2% hydroxypropyl emthylcellulose, 0.5-1% polyethylene glycol 6000,2-5% carboxymethyl starch sodium, 0.2-1% magnesium stearate.
2. spirulina tablet according to claim 1, it is characterized in that, to account for tablet weight percentages, described each constituent content: 80-82% Spirulina powder, 5-7% oligomeric xylose, 5-7% isomaltulose, 0.8-1.5% hydroxypropyl emthylcellulose, 0.5-0.7% polyethylene glycol 6000,3-4% carboxymethyl starch sodium, 0.4-0.8% magnesium stearate.
3. the preparation method of spirulina tablet described in claim 1 or 2, is characterized in that, mainly comprises the following steps:
(1) raw material sieves: Spirulina powder, oligomeric xylose, isomaltulose are crossed 80-100 mesh sieve;
(2) soft material processed: Spirulina powder, oligomeric xylose, isomaltulose mix homogeneously after step (1) being processed, add wetting agent soft material; Described wetting agent is the hydroxypropyl emthylcellulose alcoholic solution of 30-50% dissolve with ethanol by concentration;
(3) wet granular processed: soft material prepared by step (2) is crossed 30-40 eye mesh screen and makes granule;
(4) dry: the granule that step (3) is obtained carries out drying, and baking temperature is 50-70 DEG C, and the time is 20-120min, and being dried to pellet moisture is 2-4%;
(5) granulate: the dry granule that step (4) is obtained crosses 30-40 mesh sieve;
(6) always mix: in the dry granule of step (5) gained, add polyethylene glycol 6000, carboxymethyl starch sodium, magnesium stearate always mix;
(7) total mixed granule step (6) obtained carries out tabletting, inspection, packaging.
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Families Citing this family (10)
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| CN105455122A (en) * | 2014-12-05 | 2016-04-06 | 天津隆顺榕发展制药有限公司 | Spirulina tablet and preparation method and application thereof |
| CN105327360A (en) * | 2015-11-22 | 2016-02-17 | 威海百合生物技术股份有限公司 | Disintegrating agent for spirulina tablets |
| CN105533717B (en) * | 2016-01-13 | 2020-01-07 | 汤臣倍健股份有限公司 | Spirulina composition and preparation thereof |
| CN106107374A (en) * | 2016-07-02 | 2016-11-16 | 威海御膳坊生物科技有限公司 | A kind of spirulina health-care beverage and preparation method thereof |
| CN107087768A (en) * | 2017-06-15 | 2017-08-25 | 佛山市远康食品贸易有限公司 | A kind of tablet for taking regulation human body acid-base degree stage by stage and preparation method thereof |
| CN109567173A (en) * | 2019-01-16 | 2019-04-05 | 汤臣倍健股份有限公司 | A kind of Spirulin composition, spirulina disintegrating tablet and preparation method thereof |
| CN110583842A (en) * | 2019-10-28 | 2019-12-20 | 顶能科技有限公司 | Barley grass juice tablet candy and preparation method thereof |
| CN111743153A (en) * | 2020-06-17 | 2020-10-09 | 福建省神六保健食品有限公司 | Spirulina active polypeptide tablet and processing method thereof |
| CN111728210A (en) * | 2020-06-17 | 2020-10-02 | 福建省神六保健食品有限公司 | Spirulina camel colostrum protein powder and processing technology thereof |
| CN115517366B (en) * | 2022-11-02 | 2024-04-02 | 宝健（北京）生物技术有限公司 | A spirulina tablet for shortening disintegration time and relieving beta-carotene attenuation, and its preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183300A (en) * | 1996-01-22 | 1998-06-03 | 云南施普瑞有限责任公司 | Spirulina tablet and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1183300A (en) * | 1996-01-22 | 1998-06-03 | 云南施普瑞有限责任公司 | Spirulina tablet and preparing method thereof |
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