CN103211880B - Phyllanthus emblica compound capsule and preparation method thereof - Google Patents
Phyllanthus emblica compound capsule and preparation method thereof Download PDFInfo
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- CN103211880B CN103211880B CN201310122469.8A CN201310122469A CN103211880B CN 103211880 B CN103211880 B CN 103211880B CN 201310122469 A CN201310122469 A CN 201310122469A CN 103211880 B CN103211880 B CN 103211880B
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- phyllanthus emblica
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- semen
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Abstract
The invention discloses a phyllanthus emblica compound capsule and a preparation method thereof, and belongs to the technical field of medicines. The phyllanthus emblica compound capsule is prepared from a main material and auxiliary materials, wherein the main material is phyllanthus emblica; the auxiliary materials include fruit of purple perilla, semen raphani, semen cassia and hovenia dulcis thumb. The medicines are compounded with one another to promote and improve the effect, so that the defect of a single medicine is overcome. The phyllanthus emblica compound capsule has a good taste, an obvious effect and a long quality guarantee period. The production process of the phyllanthus emblica compound capsule disclosed by the invention is scientific and effective and is simple and easy to operate. Besides, purifying is carried out for the characteristics of different medicine materials, so that the active ingredients are greatly kept and the health requirements of different consumers can be satisfied.
Description
Technical field:
The present invention relates to a kind of Fructus Phyllanthi compound capsule and preparation method thereof, belong to medical art.
Background technology:
China's plant resources vast in territory is very abundant, and utilization rate lacks relatively low.According to statistics, only higher plant just about has 30000 kinds, and in the plant that these are abundant, numerous species has important edible, medical value, and their effect is simultaneously found along with the progress of science and technology and deepening continuously of research.Along with improving constantly of human living standard, the sustainable growth of world population, grain, medicine and raw material of industry demand are increasing.According to the preliminary statistics, current China carries out the raw material of industry plant only about 100 kinds of international trade as staple.The medicinal plants that World Health Organization (WHO) formally determines 20000 kinds, but only have 200 kinds to do more detailed research, and China's Chinese herbal medicine kind is more than 6000 kinds.
People develop many excellent edible, medicinal, oil plant, the raw material of industry and ornamental plant gradually from wild plant, such as: A.chinensis Planch., Fructus Rosae Normalis, Fructus Hippophae, Pericarpium Citri tangerinae, Fructus Phyllanthi, Flos Lonicerae, Herb Gynostemmae Pentaphylli, prairie milk vetch etc. are all well-known.The potential value of medicine food dual purpose plant resource is very large, and Reasonable Protection and these plants of exploitation have important scientific research and practical significance.Not only can solve the contradiction that the resource utilization of China is low, meet again the consumption demand that the numerous common people improve day by day simultaneously.
Fructus Phyllanthi medicinal history is long, is distributed in the provinces and regions such as Jilin, Liaoning, Hebei, Shanxi, Shandong, Henan, Anhui, Jiangsu, Yunnan, Tibet, and Fructus Phyllanthi fruit contains tannin 45%, seed oil content 16%.Oil includes linolenic acid, linoleic acid, oleic acid, stearic acid, Palmic acid, myristic acid etc.Leaf is containing tannin (tender leaf is containing 23% ~ 28%), kaempferol, kaempferide-3-glycoside (kaempferol-3-glucosi-de), cupreol, ellagic acid and lupeol.Bark contains tannin 28 ~ 29.36%, the colourless Herba delphinii grandiflori florigen of lupeol 2.25%, d-(d-leucodelphinidin C (15) H (14) O (3) .H (2) O) about 3.75%.Stem is containing lupeol, cupreol, ellagic acid.
The utilization of prior art to She Ganzi is made generally in granule or chewable tablet, and proportioning single be main mainly with She Ganzi, well can not play the drug effect of She Gan.Simultaneously the sub-oil content of She Gan is comparatively large, common chewable tablet or the granule resting period longer after, obtained medicine is apt to deteriorate, is unfavorable for storing.There is no the characteristic for She Ganzi and be designed with process route targetedly, mostly utilizing normal pharmaceutical technique to prepare.
Summary of the invention:
The invention provides a kind of Fructus Phyllanthi compound capsule, is auxiliary with Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae), adopts the mode of soft capsule.It can meet production, packaging, the requirement of accumulating, and drug effect mouthfeel is all good simultaneously.
Technical solution of the present invention is as follows:
A kind of Fructus Phyllanthi compound capsule, with percentage by weight note, each composition is as follows:
Its preparation method is as follows:
1, raw material is preferred
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) are selected impurity, and go mouldy product etc., and sieve dedust bits.Clear water washs rapidly, 60 ~ 95 DEG C of dryings.
2, sterilizing, drying, pulverizing
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Hoveniae (Fructus Hoveniae) four kinds are sprayed powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, and 65 ~ 75 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders.
3, Semen Cassiae extracts
Dropped into by Semen Cassiae in multi-function extractor, first time adds 10 times amount water extraction 3 hours, second time adds 8 times amount water extraction 2 hours, and third time adds 8 times amount water extraction 1 hour.Gradation is filtered, and merging filtrate enters basin.
4, concentration of liquid medicine
The water extraction medicinal liquid merged, concentrating under reduced pressure (65 DEG C ~ 75 DEG C ,-0.04 ~-0.08Mpa) to relative density is the thick paste of 1.25 ~ 1.30 (60 DEG C of heat are surveyed).
5, wet mixing
The four taste crude drug powder such as Fructus Phyllanthi and the thick paste of Semen Cassiae are put trough type mixing machine to mix 30 ± 10 minutes with rotating speed 24 revs/min and carry out drying after stirring and evenly mixing.
6, dry
(60 DEG C ~ 70 DEG C, vacuum drying oven is entered after the mixing of cream powder,-0.04 ~-0.08Mpa) dry 30 ~ 50 hours, take out extractum and break into pieces, extractum block continues to enter vacuum drying after 10 ~ 12 hours, taking-up let cool to room temperature or close to room temperature time, proceed to pulverizing process.
7, pulverize
Dry extractum block is put pulverizer and pulverizes (80-100 order).
8, always mix
Medicated powder above-mentioned steps obtained and adjuvant xylitol, sodium carboxymethyl cellulose, xylitol magnesium stearate, micropowder silica gel are put trough type mixing machine and are mixed 20 ± 5 minutes with the speed of 20 revs/min and mix homogeneously, and proceed to middle database to be tested after mixing.
9, fill
Get the qualified total mixed drug powder fully-automatic capsule filling machine of chemical examination and carry out filling by " fully-automatic capsule filling machine standard operating procedure ", control content uniformity well.Should keep negative relative with mistress between filling, dust is got rid of by dust exhaust apparatus.Temperature should control at 18-26 DEG C, and humidity should control at 45-65%.
10, polishing
Get populated capsule administration product buffing machine and carry out polishing, remove the outer unnecessary powder of capsule shells, and select defective work.
Beneficial effect of the present invention is:
Fructus Phyllanthi compound capsule of the present invention utilizes She Gan to be primary raw material, auxiliaryly joins Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) form.The composite mutual promotion of multiple medical material improves drug effect, supplements the deficiency of single medical material.Products taste is good, has a significant effect, long shelf-life.
She Gan of the present invention sub-compound capsule production technology scientific and effective, easy being easy to operates.Characteristic for different pharmaceutical raw material is purified, the effective ingredient retained to greatest extent.
Detailed description of the invention:
In order to understand technical scheme of the present invention better, be described in further detail below by way of specific embodiment, specific embodiment does not limit the present invention.
Embodiment 1:
The sub-compound capsule of a kind of She Gan is obtained by following raw material:
The sub-45g of She Gan, xylitol 15g, Fructus Perillae 11g, Semen Raphani 11g, Semen Cassiae 9g, Semen Hoveniae (Fructus Hoveniae) 8g, sodium carboxymethyl cellulose 0.3g, xylitol magnesium stearate 0.2g, micropowder silica gel 0.5g.
The preparation method of the sub-compound capsule of She Gan is as follows:
(1), raw material is preferred
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Cassiae, Semen Hoveniae (Fructus Hoveniae) are selected impurity, and go mouldy product etc., and sieve dedust bits.Clear water washs rapidly, 75 DEG C of dryings.
(2), sterilizing, drying, pulverizing
Fructus Phyllanthi, Fructus Perillae, Semen Raphani, Semen Hoveniae (Fructus Hoveniae) four kinds are sprayed powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, and 70 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders.
(3), Semen Cassiae extracts
Dropped into by Semen Cassiae in multi-function extractor, first time adds 10 times amount water extraction 3 hours, second time adds 8 times amount water extraction 2 hours, and third time adds 8 times amount water extraction 1 hour.Gradation is filtered, and merging filtrate enters basin.
(4), concentration of liquid medicine
The water extraction medicinal liquid merged, concentrating under reduced pressure (70 DEG C ,-0.06Mpa) to relative density is the thick paste of 1.30 (60 DEG C of heat are surveyed).
(5), wet mixing
The four taste crude drug powder such as Fructus Phyllanthi and the thick paste of Semen Cassiae are put trough type mixing machine to mix 35 minutes with rotating speed 24 revs/min and carry out drying after stirring and evenly mixing.
(6), dry
Enter dry 50 hours of vacuum drying oven (70 DEG C ,-0.08Mpa) after the mixing of cream powder, take out extractum and break into pieces, extractum block continues to enter vacuum drying after 10 hours, take out let cool to room temperature or close to room temperature time, proceed to pulverizing process.
(7), pulverize
Dry extractum block is put pulverizer and pulverizes (90 order).
(8), always mix
Medicated powder above-mentioned steps obtained and adjuvant xylitol, sodium carboxymethyl cellulose, xylitol magnesium stearate, micropowder silica gel are put trough type mixing machine and are mixed 23 minutes with the speed of 20 revs/min and mix homogeneously, and proceed to middle database to be tested after mixing.
(9), fill
Get the qualified total mixed drug powder NJP-1200 type fully-automatic capsule filling machine of chemical examination and carry out filling by " NJP-1200 type fully-automatic capsule filling machine standard operating procedure ", control content uniformity well.Should keep negative relative with mistress between filling, dust is got rid of by dust exhaust apparatus.Temperature should control at 22 DEG C, and humidity should control 55%.
(10), polishing
Get populated capsule YPJ-II type medicine buffing machine and carry out polishing, remove the outer unnecessary powder of capsule shells, and select defective work.By the requirement of check character composite medicine, and good mouthfeel.
Embodiment 2:
The sub-compound capsule of a kind of She Gan is obtained by following raw material:
The sub-60g of She Gan, xylitol 10g, Fructus Perillae 8g, Semen Raphani 8g, Semen Cassiae 6g, Semen Hoveniae (Fructus Hoveniae) 6.5g, sodium carboxymethyl cellulose 0.5g, xylitol magnesium stearate 0.5g, micropowder silica gel 0.5g.
Processing method is with embodiment 1.
Claims (1)
1. a Fructus Phyllanthi compound capsule, is characterized in that, is made up of the raw material of following portions by weight proportioning:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310122469.8A CN103211880B (en) | 2013-03-31 | 2013-03-31 | Phyllanthus emblica compound capsule and preparation method thereof |
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| CN201310122469.8A CN103211880B (en) | 2013-03-31 | 2013-03-31 | Phyllanthus emblica compound capsule and preparation method thereof |
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| CN103211880B true CN103211880B (en) | 2015-05-13 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103610802B (en) * | 2013-11-28 | 2016-03-16 | 王小欧 | A kind of compound recipe Radix Peucedani reducing fever relieving cough capsule and preparation method thereof |
| CN103735758A (en) * | 2013-12-12 | 2014-04-23 | 济南新起点医药科技有限公司 | Compound rhizoma typhonii capsule and preparation method thereof |
| CN103656313A (en) * | 2013-12-21 | 2014-03-26 | 山东中大药业有限公司 | Liver-calming and blood-activating compound couchgrass root capsule and preparation method thereof |
Citations (5)
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| CN101422523A (en) * | 2008-12-02 | 2009-05-06 | 昆明振华制药厂有限公司 | Health-care preparation capable of alleviating a hangover and protecting the liver and preparation method thereof |
| CN102008077A (en) * | 2010-09-26 | 2011-04-13 | 何爱霞 | Composition and health care food with the lipid-lowering efficacy as well as preparation method thereof |
| CN102217758A (en) * | 2011-04-30 | 2011-10-19 | 楚雄州百草岭药业发展有限公司 | Emblic leafflower fruit capsule and preparation method thereof |
| CN102283892A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Sanzi Yangqin decoction dosage form |
| CN102793030A (en) * | 2012-07-29 | 2012-11-28 | 天马（安徽）中药饮片科技有限公司 | Wuziyansheng plant teabag and production technology thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9238153B2 (en) * | 2011-04-21 | 2016-01-19 | Sunny Biodiscovery, Inc. | Transoral methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation |
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Patent Citations (5)
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|---|---|---|---|---|
| CN101422523A (en) * | 2008-12-02 | 2009-05-06 | 昆明振华制药厂有限公司 | Health-care preparation capable of alleviating a hangover and protecting the liver and preparation method thereof |
| CN102283892A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Sanzi Yangqin decoction dosage form |
| CN102008077A (en) * | 2010-09-26 | 2011-04-13 | 何爱霞 | Composition and health care food with the lipid-lowering efficacy as well as preparation method thereof |
| CN102217758A (en) * | 2011-04-30 | 2011-10-19 | 楚雄州百草岭药业发展有限公司 | Emblic leafflower fruit capsule and preparation method thereof |
| CN102793030A (en) * | 2012-07-29 | 2012-11-28 | 天马（安徽）中药饮片科技有限公司 | Wuziyansheng plant teabag and production technology thereof |
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| 王立群.紫苏子莱菔子.《中医临床常用药对手》.学苑出版社,2001,(第1版),第204-205页. * |
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Address after: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Applicant after: Research Institute of Agriculture Quality Standard and Testing Technology, Shandong Academy of Agricultural Sciences Address before: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Applicant before: Centra Lab, Shandong-Prov Academy of Agricutural Sciences |
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Free format text: CORRECT: APPLICANT; FROM: CENTRA LAB, SHANDONG-PROV ACADEMY OF AGRICUTURAL SCIENCES TO: SHANDONG ACADEMY OF AGRICULTURAL SCIENCES AGRICULTURAL QUALITY STANDARDS + DETECTION TECHNOLOGY RESEARCH INSTITUTE |
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Granted publication date: 20150513 Termination date: 20160331 |