CN109567173A - A kind of Spirulin composition, spirulina disintegrating tablet and preparation method thereof - Google Patents
A kind of Spirulin composition, spirulina disintegrating tablet and preparation method thereof Download PDFInfo
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- CN109567173A CN109567173A CN201910040133.4A CN201910040133A CN109567173A CN 109567173 A CN109567173 A CN 109567173A CN 201910040133 A CN201910040133 A CN 201910040133A CN 109567173 A CN109567173 A CN 109567173A
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- spirulina
- macrogol
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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Abstract
The invention belongs to technical field of health care food more particularly to a kind of Spirulin composition, spirulina disintegrating tablet and preparation method thereof.The present invention provides a kind of Spirulin compositions, comprising: spirulina, sugar alcohol, acid source, Macrogol 6000 and disintegrating agent.In the present invention, by the way that sugar alcohol, acid source, Macrogol 6000 and disintegrating agent are added in spirulina, sugar alcohol is soluble easily in water, acid source enables spirulina that can dissociate protein to reduce viscosity after its wetting, Macrogol 6000 surfactant effectively increases the dissolubility of spirulina and enhance the infiltration wetability of spirulina in acid condition, and sugar alcohol, acid source and Macrogol 6000 collaboration disintegrating agent make Spirulin composition in solvent system fater disintegration.
Description
Technical field
The invention belongs to technical field of health care food more particularly to a kind of Spirulin composition, spirulina disintegrating tablet and
Preparation method.
Background technique
Spirulina (scientific name: Spirulina) is a kind of unicellular lower eukaryote, and prokaryotes, also known as " arthrospira ", Cyanophyceae quiver
Algae section.Spirulina frond be single-row cell composition not branch filamentous, gelatinous sheath without or only very thin sheath, no heterocyst and
Akinete, to form hormocystangium breeding, body is 200~500 μm long, 5~10 μm wide, cylindrical, in loose or closely have a rule
Spiral rotation shape bending then, shaped like clockwork feed, so gain the name.About 38 kinds of spirulina type, majority is grown in alkaline salt lake.Mesh
It is preceding to have extensive artificial culture, predominantly blunt top spirulina, spirulina maxim and three kinds of India's spirulina both at home and abroad.
Spirulina has various health care functions, is a kind of promotor of broad immune system, meanwhile, to adjusting blood lipid, burst
Ulcer, anemia, diabetes, hepatopathy, vision be bad, antifatigue etc. has certain curative effect.In recent years, go deep into research, send out
In terms of existing spirulina is to anti-radiation, promotion pregnant woman's galactosis, there is preferable effect；For altitude sickness prevention, resist oxygen lack side
Also there is certain effect in face.Spirulina is a kind of high-protein food, and rationally, unsaturated fatty acid accounting is high for amino acid composition, is contained
The Y- linolenic acid that other plants do not have；Content of mineral substances is comprehensive, and vitamin content is abundant.Vegetable protein content in dry algae powder
It is 50%~70%, is equivalent to 1.68 times of soybean, 3.3 times of beef, 3.1 times of egg, 3.7 times of the flesh of fish；Its fat contains
Amount only 5%, and it is cholesterol-free, it contains 17 kinds of amino acid, and 8 kinds of amino acid necessary to human body all contain in spirulina
Have.Polysaccharide component has vigor that is anti-radiation and significantly improving cellular superoxide dismutase in spirulina, enhances the non-of body
Specific immunity improves hematopoiesis function, promotes natural killer cell activity in human peripheral blood, delays body aging；It is also
With the ability for improving macrophage removing foreign matter.Spirulina polysaccharide has apparent protective action to the damage of ionising radiation,
Mitigate destruction of the radiation treatment to cancer patient haemocyte, the adjuvant therapy medicaments of chemicotherapy are carried out as cancer patient；?
It can be used for the adjuvant treatment of anemia.The multivitamins and selenium etc. such as the β-Hu Luo element, the vitamin E that also contain in spirulina are to people
Body healthy trace elements with household ingredient with anti-cancer, anticancer, removes human free radical, enhancing immune function of human body and anti-aging
Effect.
The distinctive health-care effect of spirulina and bioactivity have obtained the extensive concern of biology, nutrition and medical field
And development and utilization.But spirulina itself has not pleasant algae fishy smell, mouthfeel is poor and to be stained with stickiness very strong, takes
It is quite inconvenient.Preferably take spirulina in order to facilitate consumer, most of enterprise be all using spirulina be made tablet as
Product sale.Spirulina contains a large amount of protein, and after tabletted, water is difficult to the greatest extent thoroughly, to send out after encountering water due to spirulina
Raw swelling causes the surface of spiral algae sheet to form one layer of water barrier and eventually leads to tablet so that water can not penetrate into inside tablet
Disintegration time is against regulation.The disintegration release time of product in vivo, shadow can be extended by being disintegrated underproof spiral algae sheet not only
Ring absorption of the body for nutritional components of the product.For the above problem, disintegration can be reduced by reducing the additive amount of spirulina
Time, however the additive amount of spirulina is reduced, it will lead to the reduction of unit slice weight internal strength effective component content, so that consumer be made to need
Taking further amounts of spiral algae sheet can be only achieved the effect of nutrition and health care.
Summary of the invention
In view of this, being used for the present invention provides a kind of Spirulin composition, spirulina disintegrating tablet and preparation method thereof
Solve existing spiral algae sheet because spirulina contains a large amount of protein, the too long problem of disintegration time.
The specific technical solution of the present invention is as follows:
A kind of Spirulin composition, comprising: spirulina, sugar alcohol, acid source, Macrogol 6000 and disintegrating agent.
The present invention by being added sugar alcohol, acid source, Macrogol 6000 and disintegrating agent in spirulina, sugar alcohol is soluble easily in water,
Acid source makes spirulina that can dissociate protein to reduce viscosity after its wetting, Macrogol 6000 surface is lived in acid condition
Property agent can effectively increase spirulina dissolubility and enhance spirulina infiltration wetability, sugar alcohol, acid source and polyethylene glycol
6000 collaboration disintegrating agents make Spirulin composition in solvent system fater disintegration.
In the present invention, spirulina is spirulina powder.
Preferably, the matter of the spirulina, the sugar alcohol, the acid source, the Macrogol 6000 and the disintegrating agent
Amount is than being (1~89): (1~70): (0.8~3.5): (1~3): (4~18).
Preferably, the matter of the spirulina, the sugar alcohol, the acid source, the Macrogol 6000 and the disintegrating agent
Amount is than being (30~78): (4~50): (0.8~3.5): (1~3): (8~18).
Preferably, the matter of the spirulina, the sugar alcohol, the acid source, the Macrogol 6000 and the disintegrating agent
Amount is than being (50~68): (10~23): (0.8~3.5): (1~3): (8~18).
The content of spirulina is smaller in Spirulin composition, and sugar alcohol, acid source, disintegrating agent, the content of polyethylene glycol are bigger, water
It is point higher to the wetting of Spirulin composition and osmotic efficiency, it is bigger with the contact area of spirulina, to Spirulin composition
It is better to be disintegrated effect.
Preferably, the sugar alcohol be selected from xylitol, maltitol, D-sorbite, isomalt, D-mannital or
Antierythrite.
Preferably, the acid source is selected from citric acid, tartaric acid or malic acid.
Preferably, the disintegrating agent is selected from croscarmellose sodium, sodium carboxymethyl starch, crosslinked polyethylene pyrrolidines
Ketone, dried starch, porous-starch or low-substituted hydroxypropyl cellulose.
The present invention also provides a kind of spirulina disintegrating tablets, including Spirulin composition and food described in above-mentioned technical proposal
Acceptable auxiliary material in conduct and learning.
The present invention is easy by the way that sugar alcohol, acid source, Macrogol 6000 and disintegrating agent, sugar alcohol are added in spirulina disintegrating tablet
It is dissolved in water, acid source makes spirulina that can dissociate protein in acid condition to reduce the viscosity after its wetting, polyethylene glycol
6000 surfactants can effectively increase the dissolubility of spirulina and enhance the infiltration wetability of spirulina, effectively reduce spiral shell
Revolve algae viscosity, water is quickly entered in the label of spirulina disintegrating tablet, at the same water with spirulina disintegrating tablet
Be not in water proof gel layer after contact, and not form penetrating passage since its hydrophily quickly absorbs water merely and draw moisture
Enter inside tablet, sugar alcohol, acid source and Macrogol 6000 collaboration disintegrating agent make spirulina disintegrating tablet quick in solvent system
Disintegration, improves the disintegration rate of spirulina disintegrating tablet.Spirulina disintegrating tablet of the present invention has any surface finish, quality steady
The advantages that determining, being convenient for carrying and take has the function of increasing immunity solve spirulina powder and existing in the application of tablet
Disintegration time limited excessive problem, while solving spirulina and taking the problems such as body-sensing is not pleasant.
Preferably, acceptable auxiliary material is selected from filler, glidant or lubricant in the bromatology.
In the present invention, acceptable auxiliary material is superfine silica gel powder and magnesium stearate in bromatology.Spirulina, acid source, gathers sugar alcohol
Ethylene glycol 6000, disintegrating agent, superfine silica gel powder and magnesium stearate mass ratio be (1~89): (1~70): (0.8~3.5): (1~
3): (4~18): (0.5~2): (0.3~1), preferably (30~78): (4~50): (0.8~3.5): (1~3): (8~
18): (0.5~2): (0.3~1), more preferably (50~68): (10~23): (0.8~3.5): (1~3): (8~18):
(0.5~2): (0.3~1).
In the prior art, spirulina can be pelletized, be dried by addition auxiliary material, total mix, the techniques preparation spiral such as tabletting
Algae piece, still, by the spirulina of wet granulation, the color of spirulina can become yellow green, the spiral algae sheet sense organ degree of extrusion
Difference, storage process stability of the effective component in the later period can also be deteriorated.Furthermore it adds excessive auxiliary material and carries out spirulina disintegrated tablet
The preparation of agent causes effective content low, and tablet quality is poor, tablet such as more containing microcrystalline cellulose, be placed on humidity compared with
Under high environment, tablet can soften.Meanwhile wet granulation is carried out to spirulina, the environment and equipment of workshop will cause
Greatly pollution, including the pollution such as smell, dyeing, unsuitable multi items share the production requirement in same production environment workshop.
The present invention also provides a kind of preparation methods of spirulina disintegrating tablet, comprising the following steps:
After auxiliary material acceptable in Spirulin composition described in above-mentioned technical proposal and bromatology is mixed, tabletting is carried out,
Obtain spirulina disintegrating tablet.
Preparation method of the present invention reduces the organic acid of spirulina stickiness by introducing, and organic acid includes citric acid, tartaric acid
And malic acid, the auxiliary materials such as sugar alcohol, disintegrating agent and Macrogol 6000 are introduced, are directly mixed with spirulina, without whole grain of pelletizing, nothing
Drying is needed, direct tablet compressing can effectively reduce the viscosity of spirulina, and water is allowed to quickly enter the label of spirulina disintegrating tablet
In, disintegration rate is improved, it is horizontal to the absorption of Analyses of Active Constituents of Spirulina Platensis to improve human body, while complying with for consumer can also be improved
Property.
Preparation method simple production process of the present invention, production environment is polluted it is small, it is high in effective component spirulina content
Under the premise of, it can substantially shorten the disintegration time of spirulina disintegrating tablet and be conducive to the nutritional ingredient of spirulina disintegrating tablet
It absorbs.The preparation method be better than tablet other preparation methods, which does not need first to pelletize carries out tabletting again, have with
Lower advantage: reducing process, and raising efficiency reduces labor intensity；It reduces and the dyeing of equipment, environment, personnel's operation is polluted.
In preparation method of the present invention, first by can in spirulina, sugar alcohol, acid source, Macrogol 6000, disintegrating agent and bromatology
The auxiliary material of receiving carries out precise by every batch of formulation dosage, chooses whether to crush, premix or be sieved according to combustion, then will
Acceptable auxiliary material is placed in mixing machine in spirulina, sugar alcohol, acid source, Macrogol 6000, disintegrating agent and bromatology, mix to
Mixed material color is homogeneous, then carries out tabletting with tablet press machine, and inspect periodically tablet weight variation.
In conclusion the present invention provides a kind of Spirulin compositions, comprising: spirulina, sugar alcohol, acid source, polyethylene glycol
6000 and disintegrating agent.It is easy by the way that sugar alcohol, acid source, Macrogol 6000 and disintegrating agent, sugar alcohol are added in spirulina in the present invention
It is dissolved in water, acid source makes spirulina that can dissociate protein in acid condition to reduce the viscosity after its wetting, polyethylene glycol
6000 surfactants can effectively increase spirulina dissolubility and enhance spirulina infiltration wetability, sugar alcohol, acid source and
Macrogol 6000 collaboration disintegrating agent makes Spirulin composition in solvent system fater disintegration.
Specific embodiment
It is existing for solving the present invention provides a kind of Spirulin composition, spirulina disintegrating tablet and preparation method thereof
Spiral algae sheet a large amount of protein because spirulina contains, the too long problem of disintegration time.
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
In the embodiment of the present invention, spirulina, sugar alcohol, acid source, Macrogol 6000, disintegrating agent, superfine silica gel powder and stearic acid
Magnesium is bought by market.
Embodiment 1
The present embodiment is by spirulina, xylitol, citric acid, Macrogol 6000, crosslinked polyvinylpyrrolidone, micro mist silicon
Glue and magnesium stearate mixing, carry out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, xylitol, citric acid, Macrogol 6000, crosslinked polyethylene
The mass ratio of pyrrolidones, superfine silica gel powder and magnesium stearate is 89:3:1:2:4:0.5:0.5.
Embodiment 2
The present embodiment is by spirulina, xylitol, citric acid, Macrogol 6000, crosslinked polyvinylpyrrolidone, micro mist silicon
Glue and magnesium stearate mixing, carry out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, xylitol, citric acid, Macrogol 6000, crosslinked polyethylene
The mass ratio of pyrrolidones, superfine silica gel powder and magnesium stearate is 75:11:2:2.5:8:1:0.5.
Embodiment 3
The present embodiment is by spirulina, xylitol, citric acid, Macrogol 6000, crosslinked polyvinylpyrrolidone, micro mist silicon
Glue and magnesium stearate mixing, carry out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, xylitol, citric acid, Macrogol 6000, crosslinked polyethylene
The mass ratio of pyrrolidones, superfine silica gel powder and magnesium stearate is 60:14:3.5:3:18:1:0.5.
Embodiment 4
The present embodiment is by spirulina, isomalt, malic acid, Macrogol 6000, carboxyrnethyl starch sodium, superfine silica gel powder
It is mixed with magnesium stearate, carries out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, isomalt, malic acid, Macrogol 6000, carboxylic first
The mass ratio of sodium starch, superfine silica gel powder and magnesium stearate is 80:4.5:2:2:10:1:0.5.
Embodiment 5
The present embodiment is by spirulina, isomalt, malic acid, Macrogol 6000, carboxyrnethyl starch sodium, superfine silica gel powder
It is mixed with magnesium stearate, carries out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, isomalt, malic acid, Macrogol 6000, carboxylic first
The mass ratio of sodium starch, superfine silica gel powder and magnesium stearate is 70:10.5:3:3:12:1:0.5.
Embodiment 6
The present embodiment is by spirulina, isomalt, malic acid, Macrogol 6000, carboxyrnethyl starch sodium, superfine silica gel powder
It is mixed with magnesium stearate, carries out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, isomalt, malic acid, Macrogol 6000, carboxylic first
The mass ratio of sodium starch, superfine silica gel powder and magnesium stearate is 65:11:3.5:3:16:1:0.5.
Embodiment 7
The present embodiment is by spirulina, D-mannital, tartaric acid, Macrogol 6000, croscarmellose sodium, micro-
Powder silica gel and magnesium stearate mixing, carry out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, D-mannital, tartaric acid, Macrogol 6000, crosslinking carboxylic
The mass ratio of sodium carboxymethylcellulose pyce, superfine silica gel powder and magnesium stearate is 85:2:2:2:8:0.5:0.5.
Embodiment 8
The present embodiment is by spirulina, D-mannital, tartaric acid, Macrogol 6000, croscarmellose sodium, micro-
Powder silica gel and magnesium stearate mixing, carry out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, D-mannital, tartaric acid, Macrogol 6000, crosslinking carboxylic
The mass ratio of sodium carboxymethylcellulose pyce, superfine silica gel powder and magnesium stearate is 70:8.5:3:3:14:1:0.5.
Embodiment 9
The present embodiment is by spirulina, D-mannital, tartaric acid, Macrogol 6000, croscarmellose sodium, micro-
Powder silica gel and magnesium stearate mixing, carry out tabletting, obtain spirulina disintegrating tablet.
In the present embodiment spirulina disintegrating tablet, spirulina, D-mannital, tartaric acid, Macrogol 6000, crosslinking carboxylic
The mass ratio of sodium carboxymethylcellulose pyce, superfine silica gel powder and magnesium stearate is 60:14:3.5:3:18:1:0.5.
Comparative example 1
This comparative example mixes spirulina, xylitol, citric acid, Macrogol 6000, superfine silica gel powder and magnesium stearate, into
Row tabletting obtains spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, xylitol, citric acid, Macrogol 6000, superfine silica gel powder and
The mass ratio of magnesium stearate is 75:11:2:2.5:1:0.5.
Comparative example 2
This comparative example is by spirulina, xylitol, Macrogol 6000, crosslinked polyvinylpyrrolidone, superfine silica gel powder and hard
Fatty acid magnesium mixing, carries out tabletting, obtains spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, xylitol, Macrogol 6000, crosslinked polyethylene pyrrolidines
The mass ratio of ketone, superfine silica gel powder and magnesium stearate is 75:11:2.5:8:1:0.5.
Comparative example 3
This comparative example is by spirulina, xylitol, citric acid, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate
Mixing carries out tabletting, obtains spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, xylitol, citric acid, crosslinked polyvinylpyrrolidone, micro mist
The mass ratio of silica gel and magnesium stearate is 75:11:2:8:1:0.5.
Comparative example 4
This comparative example is by spirulina, citric acid, Macrogol 6000, crosslinked polyvinylpyrrolidone, superfine silica gel powder and hard
Fatty acid magnesium mixing, carries out tabletting, obtains spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, citric acid, Macrogol 6000, crosslinked polyethylene pyrrolidines
The mass ratio of ketone, superfine silica gel powder and magnesium stearate is 75:2:2.5:8:1:0.5.
Comparative example 5
This comparative example mixes spirulina, xylitol, citric acid, superfine silica gel powder and magnesium stearate, carries out tabletting, obtains spiral shell
Revolve algae disintegrating tablet.
In this comparative example spirulina disintegrating tablet, the matter of spirulina, xylitol, citric acid, superfine silica gel powder and magnesium stearate
Amount is than being 75:11:2:1:0.5.
Comparative example 6
This comparative example mixes spirulina, xylitol, Macrogol 6000, superfine silica gel powder and magnesium stearate, carries out tabletting,
Obtain spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, xylitol, Macrogol 6000, superfine silica gel powder and stearic acid
The mass ratio of magnesium is 75:11:2.5:1:0.5.
Comparative example 7
This comparative example mixes spirulina, xylitol, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate, into
Row tabletting obtains spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, xylitol, crosslinked polyvinylpyrrolidone, superfine silica gel powder and
The mass ratio of magnesium stearate is 75:11:8:1:0.5.
Comparative example 8
This comparative example mixes spirulina, citric acid, Macrogol 6000, superfine silica gel powder and magnesium stearate, carries out tabletting,
Obtain spirulina disintegrating tablet.
In this comparative example spirulina disintegrating tablet, spirulina, citric acid, Macrogol 6000, superfine silica gel powder and stearic acid
The mass ratio of magnesium is 75:2:2.5:1:0.5.
Comparative example 9
This comparative example mixes spirulina, citric acid, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate, into
Row tabletting obtains spirulina disintegrating tablet.
This comparative example spirulina, citric acid, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate mass ratio be
75:2:8:1:0.5.
Comparative example 10
This comparative example mixes spirulina, Macrogol 6000, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate
It closes, carries out tabletting, obtain spirulina disintegrating tablet.
This comparative example spirulina, Macrogol 6000, crosslinked polyvinylpyrrolidone, the matter of superfine silica gel powder and magnesium stearate
Amount is than being 75:2.5:8:1:0.5.
Comparative example 11
This comparative example mixes spirulina, xylitol, superfine silica gel powder and magnesium stearate, carries out tabletting, obtains spirulina and collapse
Solve tablet.
This comparative example spirulina, xylitol, superfine silica gel powder and magnesium stearate mass ratio be 75:11:1:0.5.
Comparative example 12
This comparative example mixes spirulina, citric acid, superfine silica gel powder and magnesium stearate, carries out tabletting, obtains spirulina and collapse
Solve tablet.
This comparative example spirulina, citric acid, superfine silica gel powder and magnesium stearate mass ratio be 75:2:1:0.5.
Comparative example 13
This comparative example mixes spirulina, Macrogol 6000, superfine silica gel powder and magnesium stearate, carries out tabletting, obtains spiral shell
Revolve algae disintegrating tablet.
This comparative example spirulina, Macrogol 6000, superfine silica gel powder and magnesium stearate mass ratio be 75:2.5:1:0.5.
Comparative example 14
This comparative example mixes spirulina, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate, carries out tabletting,
Obtain spirulina disintegrating tablet.
This comparative example spirulina, crosslinked polyvinylpyrrolidone, superfine silica gel powder and magnesium stearate mass ratio be 75:8:1:
0.5。
Embodiment 10
The present embodiment is according to 2010 editions-disintegration time limit test of Chinese Pharmacopoeia to 1~14 spiral shell of Examples 1 to 9 and comparative example
The disintegration time of rotation algae disintegrating tablet is detected, and testing result please refers to table 1.The result shows that spirulina of the embodiment of the present invention
The disintegration time of disintegrating tablet is both less than 30 minutes, hence it is evident that better than the disintegration time of comparative example spirulina disintegrating tablet, sugar alcohol, acid
Source and Macrogol 6000 can cooperate with disintegrating agent to make the present embodiment Spirulin composition in solvent system fater disintegration.
The disintegration time of 1~14 spirulina disintegrating tablet of 1 Examples 1 to 9 of table and comparative example
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Spirulin composition characterized by comprising spirulina, sugar alcohol, acid source, Macrogol 6000 and disintegrating agent.
2. Spirulin composition according to claim 1, which is characterized in that the spirulina, the sugar alcohol, the acid
The mass ratio in source, the Macrogol 6000 and the disintegrating agent is (1~89): (1~70): (0.8~3.5): (1~3): (4
~18).
3. Spirulin composition according to claim 2, which is characterized in that the spirulina, the sugar alcohol, the acid
The mass ratio in source, the Macrogol 6000 and the disintegrating agent is (30~78): (4~50): (0.8~3.5): (1~3):
(8~18).
4. Spirulin composition according to claim 3, which is characterized in that the spirulina, the sugar alcohol, the acid
The mass ratio in source, the Macrogol 6000 and the disintegrating agent is (50~68): (10~23): (0.8~3.5): (1~3):
(8~18).
5. Spirulin composition according to claim 1, which is characterized in that the sugar alcohol be selected from xylitol, maltitol,
D-sorbite, isomalt, D-mannital or antierythrite.
6. Spirulin composition according to claim 1, which is characterized in that the acid source be selected from citric acid, tartaric acid or
Malic acid.
7. Spirulin composition according to claim 1, which is characterized in that the disintegrating agent is selected from cross-linked carboxymethyl fiber
Plain sodium, sodium carboxymethyl starch, crosslinked polyvinylpyrrolidone, dried starch, porous-starch or low-substituted hydroxypropyl cellulose.
8. a kind of spirulina disintegrating tablet, which is characterized in that including Spirulin composition described in claim 1 to 7 any one
With auxiliary material acceptable in bromatology.
9. spirulina disintegrating tablet according to claim 8, which is characterized in that acceptable auxiliary material choosing in the bromatology
From filler, glidant or lubricant.
10. a kind of preparation method of spirulina disintegrating tablet, which comprises the following steps:
After auxiliary material acceptable in Spirulin composition described in claim 1 to 7 any one and bromatology is mixed, pressed
Piece obtains spirulina disintegrating tablet.
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| CN115517366A (en) * | 2022-11-02 | 2022-12-27 | 宝健（北京）生物技术有限公司 | Spirulina tablet for shortening disintegration time and slowing attenuation of beta-carotene and preparation method thereof |
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