CN1864699A - Novel dosage form of multiple Vitamins - Google Patents
Novel dosage form of multiple Vitamins Download PDFInfo
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- CN1864699A CN1864699A CN 200510040153 CN200510040153A CN1864699A CN 1864699 A CN1864699 A CN 1864699A CN 200510040153 CN200510040153 CN 200510040153 CN 200510040153 A CN200510040153 A CN 200510040153A CN 1864699 A CN1864699 A CN 1864699A
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- vitamin
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Abstract
The present invention relates to one new form of vitamin preparation with stable vitamin components and easy analysis and determination of the vitamin components. Compatible vitamin and trace element components are first formed into micro tablets with coating of different colors and then encapsulated. The new form of vitamin preparation has improved compliance.
Description
Technical field
The present invention relates to a kind of novel pharmaceutical formulation.
Background technology
Vitamin and mineral are to keep body homergy and healthy requisite important substance, are the important component that constitutes multiple coenzyme and hormone, participate in saccharide, aminoacid, lipid metabolism in the body.When because of disease or undernutrition, can cause vitamin, mineral deficiency, and then cause dysbolismus, cause multiple disease, must give necessary replenishing.The vitamin administration commonly used or the use dosage form of food additive mostly are oral tablet, capsule, granule etc., and patient weak or that be in hospital can also use injection type.
Usually, oral multivitamin often replenishes simultaneously with trace element.The complicated component of its compound preparation is generally made tablet more.Owing to, must use certain stabilizing agent in order to overcome some vitamins stability poor (as vitamin A, vitamin E, vitamin C etc.), cause tablet volume bigger, be inconvenient to swallow.Some vitamin have special odor, also influence particularly child's use of people.Some high-valency metal elements can produce complex reaction with some vitamin (vitamin C etc.), to chemical property, absorption feature generation harmful effect each other.
According to dissolving characteristic, vitamin generally can be divided into water solublity and fat-soluble two big classes, simply with its mixing, be prepared into tablet, when measuring each composition, need extract, separate, be inconvenient to carry out quality controls such as assay, even may interfere with each other mensuration.
The redox characteristic of material is a kind of relative characteristic, vitamin A, vitamin C, vitamin E etc. all have certain redox characteristic, simply with after its mixing, being prepared into single conventional tablet, the stronger vitamin of reproducibility may interact with the stronger vitamin of oxidisability, thereby influences its stability.
The objective of the invention is: a kind of stability of each composition of maintenance and multivitamin novel form that convenient all kinds of component analyses are measured of being beneficial to is provided.
The technical scheme that realizes the object of the invention is as follows:
1, multivitamin novel form comprises not having incompatibility or each other no interactional vitamin, trace element composition behind the compatibility each other, it is characterized in that:
Do not have each other incompatibility or each other behind the compatibility no interactional vitamin, trace element composition be respectively little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
2, according to above-mentioned 1 described multivitamin novel form, it is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional more than two kinds vitamin, trace element blending constituent be little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
3, according to above-mentioned 1 described multivitamin novel form, it is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional water soluble vitamins more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional fatsoluble vitamin more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional trace element more than two kinds be little shape tablet with different colours film-coat; And be positioned at capsule.
4, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-20.
5, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-5.
6, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described capsule is the colored transparent capsule, or not colourless transparent capsule.
7, according to above-mentioned 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described little shape tablet also can be drop pill, is little soft capsule.
Useful technique effect of the present invention shows following aspect:
The present invention is by after being prepared into small tablet with mutual influential vitamin, trace element grouping, fill, be packaged in the transparent capsule shells, the assay determination that not only helps improving the stability of each composition and make things convenient for each constituents, each tablet can also be wrapped the film-coat of different colours, to improve the compliance that people use.
The present invention can also be prepared into small tablet with vitamin, the trace element grouping with abnormal flavour and carry out coating to isolate bad smell, small tablet is filled, is packaged in the transparent capsule shells, each tablet can also be wrapped the film-coat of different colours, not only improve the compliance that people use in appearance, can also significantly improve the ubiquitous abnormal flavour shortcoming of general compound vitamin oral formulations.
The present invention also can make some vitamin, the mineral that can make soft capsule or drop pill the small tablet made from other compositions behind small drop pill or the soft capsule and be sub-packed in the transparent capsule jointly.This dosage form is compared the convenience with tangible novelty and assay determination with traditional vitamins dosage form.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Novel form of the present invention is that vitamin, trace element are divided into groups according to the convenience of physicochemical property, interaction characteristic and the pharmaceutical analysis of each composition, after each group compositions added suitable adjuvant, respectively make small tablet after, be surrounded by color or white clothing, be filled in transparent, the coloured or colourless capsule shells.As required, the small tablet at composition place that abnormal flavour is arranged is isolated the abnormal flavour coating, to reach the purpose of shielding abnormal flavour.After relevant composition also can be made small drop pill or soft capsule, be sub-packed in the transparent capsule jointly with the small tablet of other compositions.
Embodiment 1:
According to dissolving characteristic,, be pressed into microplate with the water soluble vitamins mix homogeneously; With fatsoluble vitamin with dissolution with solvents after, absorb mixing, system soft material, 20 mesh sieve system granules, tabletting with adjuvant.Trace element is mixed with adipokinetic hormone, L-lysine, inositol etc., add adjuvant, mixing is a binding agent with 3%PVP solution, system soft material, 20 mesh sieve system granules, tabletting.For regulating the weight of tablet, the calcium hydrogen phosphate in the trace element is distributed in each small tablet.Adjuvant in each small tablet is mainly microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20), regulates each sheet with it and heavily is about 170mg.Tablet producing technology is according to conventional treatment, and the shape of tablet can be pressed into similar cylinder, and two ends are shallow arcuation, are beneficial to coating.The water soluble vitamins sheet packs into orange, and the fatsoluble vitamin sheet packs into white tablets, and the trace element sheet packs into green sheet.Each color chips is filled in the water white capsule shells, promptly successively.
| The sheet color | Orange | White tablets | Green sheet |
| Crude drug | Vitamin B1 2.5mg vitamin B2 2.5mg vitamin B6 250ug cobalamin 0.5ug niacinamide 7.5mg vitamin C 25mg calcium pantothenate 2.5mg | Vitamin A 2500IU vitamin D 200IU vitamin E 5mg | Lipotropin 25mg 1B 12.5mg iron 5mg potassium 5mg copper 500ug manganese 500ug inositol 25mg magnesium 500ug iodine 50ug zinc 250ug |
| Calcium hydrogen phosphate 100mg | Calcium hydrogen phosphate 130mg | Calcium hydrogen phosphate 50mg | |
| Microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20) | Add to 170mg | Add to 170mg | Add to 170mg |
| Magnesium stearate | 3mg | 3mg | 3mg |
| The coating color | Orange | White tablets | Green sheet |
| Capsule shells | Water white transparency | ||
Embodiment 2:
According to dissolving characteristic,, be pressed into microplate with the water soluble vitamins mix homogeneously; With fatsoluble vitamin with dissolution with solvents after, absorb mixing, system soft material, 20 mesh sieve system granules, tabletting with adjuvant and calcium hydrogen phosphate.With other trace element mix homogeneously, add adjuvant, mixing is a binding agent with 3%PVP solution, system soft material, 20 mesh sieve system granules, tabletting.Adjuvant in each sheet is mainly microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20), and regulating each sheet with it heavily is 160mg.Tablet producing technology is according to conventional treatment, and the shape of tablet can be pressed into similar cylinder, and two ends are shallow arcuation, are beneficial to coating.The water soluble vitamins sheet packs into orange, and the fatsoluble vitamin sheet packs the au bleu sheet, and the trace element sheet packs into the cherry red sheet.Each color chips is filled in the water white capsule shells successively, that is, concrete composition sees the following form.
| The sheet color | Orange | Blue sheet | The cherry red sheet |
| Crude drug | Vitamin B1 3mg vitamin B2 3.4mg vitamin B6 3mg cobalamin 9ug niacinamide 20mg vitamin C 90mg pantothenic acid 10mg | Vitamin A 5000IU vitamin D 400IU vitamin E 30IU calcium 40mg phosphorus 31mg | Ferrum 27mg copper 2mg iodine 150ug zinc 15mg magnesium 100mg chromium 15 μ g molybdenums 15 μ g |
| Folic acid 400ug biotin 30ug | Selenium 10 μ g manganese 5mg chlorine 7.5mg potassium 7.5mg | ||
| Microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20) | Add to 160mg | Add to 160mg | 0 |
| Magnesium stearate | 3mg | 3mg | 3mg |
| The coating color | Orange | Blue sheet | Red tab |
| Capsule shells | Light green is transparent | ||
Embodiment 3:
According to dissolving characteristic,, add suitable adjuvant and be pressed into microplate the water soluble vitamins mix homogeneously; Fatsoluble vitamin with after the oiliness adjuvant dissolving, is made drop pill or soft capsule.Compacting is in blocks separately with calcium hydrogen phosphate, and other trace element mix with adipokinetic hormone, L-lysine, inositol etc., add adjuvant, and mixing is a binding agent with 3%PVP solution, system soft material, 20 mesh sieve system granules, tabletting.Adjuvant in each sheet is mainly microcrystalline Cellulose-low-substituted hydroxypropyl cellulose (100 orders, ratio 80: 20), and regulating each sheet with it heavily is 150mg.Tablet producing technology is according to conventional treatment, and the shape of tablet can be pressed into similar cylinder, and two ends are shallow arcuation, are beneficial to coating.The water soluble vitamins sheet packs into orange, and the fatsoluble vitamin sheet packs into white tablets, and the trace element sheet packs into green sheet.Each color chips and drop pill or soft capsule are filled in the transparent capsule shells of light crocus successively, that is, concrete composition sees the following form.
| The sheet color | Orange | Drop pill or soft capsule | White tablets | Green sheet |
| Crude drug | Vitamin B1 2.5mg vitamin B2 2.5mg vitamin B6 250ug cobalamin 0.5ug niacinamide 7.5mg vitamin C 25mg calcium pantothenate 2.5mg | Vitamin A 2500IU vitamin D 200IU vitamin E 5mg | Lipotropin 25mg 1B 12.5mg iron 5mg potassium 5mg copper 500ug manganese 500ug inositol 25mg magnesium 500ug iodine 50ug zinc 250ug | Calcium hydrogen phosphate 180mg |
| Microcrystalline Cellulose-low the replacement | Add to 150mg | 0 | Add to 150mg | 0 |
| Hyprolose (100 orders, ratio 80: 20), | ||||
| Magnesium stearate | 3mg | 0 | 3mg | 3mg |
| The coating color | Orange | White tablets | Green sheet | |
| Capsule shells | Light crocus transparent capsule | |||
Claims (7)
1, multivitamin novel form comprises not having incompatibility or each other no interactional vitamin, trace element composition behind the compatibility each other, it is characterized in that:
Do not have each other incompatibility or each other behind the compatibility no interactional vitamin, trace element composition be respectively little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
2, multivitamin novel form according to claim 1, it is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional more than two kinds vitamin, trace element blending constituent be little shape tablet with different colours film-coat, and the little shape tablet with different colours film-coat is positioned at capsule;
Described vitamin is vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E;
Described trace element is ferrum, copper, iodine, zinc, magnesium, chromium, molybdenum, selenium, manganese, chlorine, potassium.
3, multivitamin novel form according to claim 1 is characterized in that: do not have each other incompatibility or each other behind the compatibility no interactional water soluble vitamins more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional fatsoluble vitamin more than two kinds be little shape tablet with different colours film-coat; Do not have each other incompatibility or each other behind the compatibility no interactional trace element more than two kinds be little shape tablet with different colours film-coat; And be positioned at capsule.
4, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-20.
5, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: the little shape tablet quantity in the described capsule is 3-5.
6, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described capsule is the colored transparent capsule, or not colourless transparent capsule.
7, according to claim 1 or 2 or 3 described multivitamin novel forms, it is characterized in that: described little shape tablet also can be drop pill, is little soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510040153 CN1864699A (en) | 2005-05-20 | 2005-05-20 | Novel dosage form of multiple Vitamins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510040153 CN1864699A (en) | 2005-05-20 | 2005-05-20 | Novel dosage form of multiple Vitamins |
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| CN1864699A true CN1864699A (en) | 2006-11-22 |
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| CN 200510040153 Pending CN1864699A (en) | 2005-05-20 | 2005-05-20 | Novel dosage form of multiple Vitamins |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401809B (en) * | 2008-11-12 | 2011-07-20 | 杭州赛诺菲民生健康药业有限公司 | Preparation for composition of vitamin and mineral matter |
| CN102302512A (en) * | 2011-08-10 | 2012-01-04 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102578572A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Mineral and vitamin nutritional supplement |
| CN107712857A (en) * | 2017-10-18 | 2018-02-23 | 北京逯博士行为医学科技研究院有限公司 | A kind of Chinese meal bag and preparation method thereof |
-
2005
- 2005-05-20 CN CN 200510040153 patent/CN1864699A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401809B (en) * | 2008-11-12 | 2011-07-20 | 杭州赛诺菲民生健康药业有限公司 | Preparation for composition of vitamin and mineral matter |
| CN102302512A (en) * | 2011-08-10 | 2012-01-04 | 杭州海王生物工程有限公司 | Multi-vitamin mineral tablet |
| CN102578572A (en) * | 2012-02-23 | 2012-07-18 | 南京辰逸生物科技有限公司 | Mineral and vitamin nutritional supplement |
| CN107712857A (en) * | 2017-10-18 | 2018-02-23 | 北京逯博士行为医学科技研究院有限公司 | A kind of Chinese meal bag and preparation method thereof |
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