CN110720631A - Nutrient composition for middle pregnancy period and preparation method and application thereof - Google Patents

Nutrient composition for middle pregnancy period and preparation method and application thereof Download PDF

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Publication number
CN110720631A
CN110720631A CN201911218719.1A CN201911218719A CN110720631A CN 110720631 A CN110720631 A CN 110720631A CN 201911218719 A CN201911218719 A CN 201911218719A CN 110720631 A CN110720631 A CN 110720631A
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pregnancy
weight
parts
nutrient composition
granules
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睢大筼
翟永信
董守光
姜国魏
姜世超
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Jilin Hongwuwei Biotechnology Co Ltd
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Jilin Hongwuwei Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
    • A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a nutrient composition in the middle of pregnancy and a preparation method and application thereof, wherein the raw materials of the composition comprise: calcium carbonate, ferrous fumarate, zinc gluconate, selenium-enriched yeast, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid, and D-calcium pantothenate; the auxiliary materials comprise: microcrystalline cellulose, crospovidone, povidone K30, maltodextrin, dextrin, magnesium stearate, sucrose, edible corn starch, acacia gum, dl-alpha-tocopherol, tricalcium phosphate, and coating premix. The invention scientifically supplements minerals such as calcium, iron, zinc, selenium and the like and multiple vitamins according to physiological characteristics and nutritional requirements of pregnant women in the middle of pregnancy, simultaneously prevents birth defects such as fetal congenital rickets, neural tube malformation and the like, prevents pregnancy complications such as anemia in pregnancy, hypertension, gestational diabetes and the like, and bad pregnancy fatality such as giant children, dystocia and the like, and is an ideal health food for the pregnant women in the middle of pregnancy.

Description

Nutrient composition for middle pregnancy period and preparation method and application thereof
Technical Field
The invention relates to the technical field of pregnant woman nutrition health products, in particular to a nutrient composition in the middle of pregnancy and a preparation method and application thereof.
Background
The term "pregnancy middle term" means from 13 weeks to 28 weeks of pregnancy. The period is that the fetal organ system is in the differentiation and fixed base stage, the growth of the fetus is fast, the volume is obviously increased, and the consumption of the pregnant woman to protein and heat is about 10 to 20 percent higher than that of normal people. The food intake of pregnant women is obviously increased along with the reduction of pregnancy reaction, but the food intake is increased while paying attention to balanced nutrition, otherwise malnutrition or deficiency can be caused, the maternal health is influenced, and the normal growth and development of fetuses are hindered.
At present, the main diet problems of pregnant women in China are as follows: 1) excessive food intake, pregnancy complications such as gestational hypertension and gestational diabetes, and adverse pregnancy fatality such as giant child and dystocia; 2) the consumption of the polished rice flour causes the deficiency of B vitamins, which is not beneficial to the development of fetuses; 3) nutrient deficiency or lack of instruction from the dietician, the appearance of abused nutrients leads to poor pregnancy outcome. Therefore, the nutrient intake of the pregnant women in the middle of pregnancy is comprehensive and balanced; to avoid the above dietary problems, relevant functional foods should be supplemented under the guidance of dieticians. However, the existing products in the market share one formula for four stages of pregnancy, and no special nutritional health-care food for the pregnant women in the middle pregnancy period is provided aiming at the characteristics of the pregnant women in the middle pregnancy period.
Disclosure of Invention
The invention aims to provide a nutrient composition in the middle of pregnancy aiming at the development characteristics and nutritional requirements of a fetus in the middle of pregnancy of a pregnant woman, and the nutrient composition is an ideal health-care food in the middle of pregnancy of the pregnant woman.
The technical scheme adopted by the invention for solving the technical problem is as follows:
the nutrient composition for the middle pregnancy comprises the following raw materials in parts by weight:
Figure BDA0002300202980000011
preferably, the nutrient composition for the middle trimester comprises the following raw materials in parts by weight:
Figure BDA0002300202980000022
furthermore, the nutrient composition for the middle trimester comprises 0-5 parts of enzyme by weight.
Wherein the ferment is one or two of protease and oxidoreductase.
Further, the nutrient composition in the middle pregnancy period is mixed with pharmaceutically acceptable auxiliary materials to be prepared into tablets, granules or capsules.
Preferably, the raw materials are mixed with the following auxiliary materials in parts by weight to prepare tablets:
Figure BDA0002300202980000023
Figure BDA0002300202980000031
more preferably, the composition is mixed with the following auxiliary materials in parts by weight to prepare a tablet:
Figure BDA0002300202980000032
the invention also provides the nutrient composition for the middle pregnancy period, and the preparation method comprises the following steps:
s1, premixing
Mixing 50% of the crospovidone in parts by weight with the dextrin in parts by weight, and mixing with the microcrystalline cellulose in parts by weight by an equivalent incremental method; then uniformly mixing the raw materials with the parts by weight by an equivalent incremental method to prepare mixed powder;
s2, granulating and drying
The povidone K30 in parts by weight is dissolved in 60% ethanol to be used as a wetting agent, and the mixed powder is added for wetting to prepare a soft material; granulating by using a 18-mesh screen, flatly paving wet granules in a stainless steel plate, wherein the thickness of the wet granules cannot exceed 2 cm, drying by hot air circulation at the temperature of 40 ℃ until the moisture is 3-5%, and preparing dry granules;
s3, straightening granules
Collecting the dry granules, and grading the granules through a 16-mesh sieve to prepare granules after grading;
s4 Total mixing
Adding the rest of crospovidone into the granules after finishing granules, adding the magnesium stearate in the parts by weight, and performing total mixing operation to obtain a total mixed material;
s5, tabletting
Loading a punch die on a tablet press, adjusting the loading amount, pressure and rotating speed by using particles, and tabletting to obtain plain tablets, wherein the weight range of the tablets is controlled to be 0.97g +/-5%;
s6 coating
Taking the coating premix, and adding 50% ethanol to prepare a coating solution with the solid content of 10%; and (3) taking the plain tablets, putting the plain tablets into a coating machine, preheating the plain tablets, uniformly spraying a coating solution on the surfaces of the plain tablets, continuously blowing hot air at 40 ℃ for 5-10 minutes after the coating solution is sprayed, blowing cold air to the surfaces of the plain tablets to reach room temperature, taking out the coated tablets, and obtaining the coated tablets, wherein the coating weight is increased by 2.85-3.15%.
In addition, the invention also provides the application of the nutrient composition in the middle pregnancy period as a nutrient substance in the middle pregnancy period of the pregnant women. Specifically, the eating amount and the eating method are as follows: it is taken 2 times daily, 1 tablet each time, with warm water.
In the technical scheme, calcium carbonate, ferrous fumarate, zinc gluconate, selenium-enriched yeast, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid and D-calcium pantothenate are used as raw materials, and the reasons are that:
the term "midgestation" (13-27 weeks) is the skeletal development stage of the fetus, during which the body weight of a baby rapidly increases. At this time, attention needs to be paid to the supplement of elements such as calcium, iron and the like which are helpful for the skeletal development of the infants. The standard daily intake of calcium and iron was 1000mg, 25mg, respectively. Sufficient calcium helps the development of fetal bones and avoids the discomfort of leg cramping in pregnant women. Meanwhile, sufficient iron can help pregnant women to prevent anemia. Among the Chinese residents, dietary nutrient reference (DRI) indicates that: the standard supply amount of calcium in the pregnant women in the middle pregnancy period is 1000 mg/day. However, pregnant women in our country are often in a low calcium state. When the calcium in the body of the pregnant woman is not taken enough, the pregnant woman needs to use the bone calcium for storage in order to meet the needs of the fetus, so that the pregnant woman is lack of calcium. A large amount of data show that hypocalcemia is closely related to pregnancy-hypertension. Reasonable calcium supplement in the middle of pregnancy has certain effects on reducing pregnancy-induced hypertension and reducing intrauterine growth retardation of fetus. The total iron requirement of general pregnant women is more than 6 times that of non-pregnant women, the iron deficiency of pregnant women can cause congenital iron storage deficiency of newborns, the fetal and newborn erythrocyte metabolism is directly influenced, the chronic hypoxia and growth and development disorder of the fetuses and the newborns are caused, and the iron deficiency is a main reason of the anemia of the pregnant women. The zinc deficiency of pregnant women can cause the growth and development retardation, abortion, premature delivery, malformation, etc. of fetus. The dietary zinc nutrition guidance for the women in the middle of pregnancy can improve the blood zinc concentration and pregnancy fate in the late pregnancy and improve the growth and development indexes of the newborn. Research finds that the zinc supplement can improve the serum zinc concentration of pregnant women in the middle and late pregnancy, and the zinc supplement can be helpful for increasing the birth weight of the newborn of the pregnant women with low serum zinc concentration in the middle pregnancy. As reported in the journal of obstetrics and gynecology in the United states, pregnant women who are selenium-deficient in their bodies have a 4-fold higher risk of developing preeclampsia than other pregnant women, which is manifested by hypertension, renal dysfunction and placental blood supply deficiency. One of the causes of preeclampsia is that placental insufficiency produces oxidants and selenium is an antioxidant, so that pregnant women must pay attention to selenium supplementation during pregnancy. The pregnant woman serum selenium is obviously lower than that of a non-pregnant woman along with the pregnant period, the selenium content in the newborn umbilical serum is low, the selenium content is possibly a factor for generating low weight, and in order to meet the normal development of a fetus, attention is paid to supplement selenium for the pregnant woman.
VA can maintain normal visual function, maintain epithelial cell health, and promote growth and reproduction. The pregnant women lack VA in vivo, and the pregnant women can have nyctalopia, premature delivery and fetal malformation. Lack or excess of VA in the middle of pregnancy can lead to abnormal embryonic development. Researches show that pregnant women with reasonable VA intake only account for 11.33%, women in middle period of pregnancy have insufficient intake of VB, calcium, iron, retinol and the like, and anemic pregnant women have insufficient intake of VB1, VB2 and calcium in different degrees. The pregnant woman has insufficient energy in the middle pregnancy period, VB1, VB2 and Ca intake, and the weight of the newborn is positively correlated with the weight index of the pregnant woman, the energy in the middle pregnancy period, protein, fat, VB1 and VB2 intake; GDM and postpartum hemorrhage may be related to certain nutritional indexes in the early and middle pregnancy; the nutritional status in the middle of pregnancy has a greater impact on pregnancy outcome than in the early pregnancy. The folic acid supplemented to women of childbearing age can reduce fetal neural tube malformation such as cleft lip and palate, reduce pregnancy complications such as premature delivery, low-quality infants, induction of labor, dead fetus, and gestational hypertension, improve pregnancy fatality such as fetal distress and newborn asphyxia, and improve maternal-fetal prognosis. VC supplementation during pregnancy can prevent premature rupture of membranes, and can prevent preeclampsia to a certain extent. The intake of nicotinic acid in pregnant women is positively correlated with the level of cord blood adiponectin, and the level of adiponectin has influence on the growth and development of fetuses: the level of cord blood adiponectin is positively correlated with the birth weight and the birth length of the fetus. Pantothenic acid can help the formation of cells, maintain normal development and the development of the central nervous system; preventing fatigue, relieving inappetence and nausea; has the function of producing antibodies, and can help to resist infectious diseases and alleviate allergy symptoms. In addition, the enzyme has the functions of assisting proteolysis, promoting nutrient absorption and improving immunity, and is beneficial to the development and growth of fetuses.
In conclusion, the nutrition requirements of all stages of the pregnancy are different, the middle pregnancy period is a key period for inoculating new life, and is a window period that nutrition influences the life health of the new life. The nutritional status of pregnant women directly affects their own and fetal health. The lack of nutrition during pregnancy can lead to the poor development of fetal organs or intrauterine growth retardation, and in severe cases, abortion, stillbirth or malformation can occur. The invention has the advantages that each stage of fetal development is known, the physiological characteristics and the nutritional requirements of pregnant women in the middle of pregnancy are met, the gold proportion of nutrition in each stage is emphasized, minerals such as calcium, iron, zinc, selenium and the like and multiple vitamins are scientifically supplemented, meanwhile, birth defects such as fetal congenital rickets, neural tube malformation and the like are prevented, and pregnancy complications such as anemia in pregnancy, hypertension, diabetes in pregnancy and the like and poor pregnancy fatigues such as giant children, dystocia and the like are prevented.
Detailed Description
The invention relates to a nutrient composition for the middle pregnancy, which comprises the following components:
raw materials: calcium carbonate, ferrous fumarate, zinc gluconate, selenium-enriched yeast, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid, and D-calcium pantothenate;
auxiliary materials: microcrystalline cellulose, crospovidone, povidone K30, maltodextrin, dextrin, magnesium stearate, sucrose, edible corn starch, acacia gum, dl-alpha-tocopherol, tricalcium phosphate, and coating premix (hydroxypropyl methylcellulose, polyethylene glycol 6000, glycerol, talc, titanium dioxide, and yellow iron oxide).
The raw materials and auxiliary materials are processed by main processes of mixing, granulating, drying, finishing, total mixing, tabletting, coating, aluminum-aluminum packaging, external packaging and the like.
The quality requirements of raw materials and auxiliary materials are as follows:
1. calcium carbonate: the calcium carbonate injection should meet the corresponding regulations of GB 1886.214 calcium carbonate (including light calcium carbonate and heavy calcium carbonate).
2. Selenium-rich yeast: the product should meet the corresponding regulation of national drug standard WS1- (x-005) -99Z selenium Yeast.
3. Ferrous fumarate: it should meet the corresponding regulations of ferrous fumarate in the second part of the Chinese pharmacopoeia (2015 edition).
4. Zinc gluconate: the regulation should meet the corresponding regulation of GB 8820 zinc gluconate.
5. Retinyl acetate: the vitamin C should meet the corresponding regulation of GB 14750 vitamin A.
6. Thiamine hydrochloride: it should meet the corresponding regulations of GB 14751 vitamin B1 (thiamine hydrochloride).
7. Riboflavin: the vitamin D should meet the corresponding regulations of GB 14752 vitamin B2 (riboflavin).
8. Pyridoxine hydrochloride: it should meet the corresponding regulation of GB 14753 vitamin B6 (pyridoxine hydrochloride).
9. Nicotinic acid: the corresponding regulation of GB 14757 Niacin should be met.
10. Folic acid: the corresponding regulation of GB 15570 Folic acid is met.
11. Vitamin C (L-ascorbic acid): it should meet the corresponding regulations of GB 14754 vitamin C (ascorbic acid).
Calcium D-pantothenate: it should meet the corresponding regulations of calcium pantothenate in the second part of the Chinese pharmacopoeia (2015 edition).
13. Microcrystalline cellulose: the product meets the corresponding regulation of GB 1886.103 food safety national standard food additive microcrystalline cellulose.
14. Cross-linked povidone: it should meet the corresponding regulations of the four parts of the Chinese pharmacopoeia (2015 edition) of crospovidone.
15. Povidone K30: it should meet the corresponding regulations of "Povidone K30" in the four parts of the Chinese pharmacopoeia (2015 edition).
16. Maltodextrin, 2: the corresponding regulation of GB/T20884 maltodextrin should be met.
17. Dextrin: it should meet the requirements of dextrin in the four parts of Chinese pharmacopoeia (2015 edition).
18. Magnesium stearate: the magnesium stearate powder should meet the corresponding regulations of GB 1886.91 magnesium stearate.
19. Sucrose: it should conform to the corresponding regulation of sucrose in the four parts of the Chinese pharmacopoeia (2015 edition).
20. Edible corn starch: the product meets the corresponding regulation of GB/T8885 edible corn starch.
21. Gum arabic: the gum meets the corresponding regulation of GB 29949 national standard for food safety, namely acacia.
Dl- α -tocopherol: the vitamin E (dl-alpha-tocopherol) food additive meets the corresponding regulations of GB 29942 national standard for food safety.
23. Tricalcium phosphate: the product is in accordance with the corresponding regulation of GB 25558 food additive tricalcium phosphate (national food safety standard).
The medical aluminum foil meets the medical aluminum foil (YBB 00152002-2015); the polyamide/aluminum/polyvinyl chloride cold stamping solid medicinal composite hard sheet meets the requirements of polyamide/aluminum/polyvinyl chloride cold stamping solid medicinal composite hard sheet (YBB 00242002-2015).
The present invention will be described in further detail with reference to examples.
EXAMPLE 1 preparation of nutrient composition for mid-pregnancy
The invention relates to a nutrient composition in the middle of pregnancy, which comprises the following raw and auxiliary materials:
Figure BDA0002300202980000071
Figure BDA0002300202980000081
wherein the coating premix is prepared by mixing hydroxypropyl methylcellulose, polyethylene glycol 6000, glycerol, talcum powder, titanium dioxide and yellow ferric oxide by a conventional method.
The preparation method of the nutrient composition in the middle of pregnancy comprises the following steps:
1 premixing
Mixing the 50% of crospovidone with dextrin; mixing with microcrystalline cellulose by equivalent incremental method; and then uniformly mixing the powder with the premixed raw materials by an equivalent incremental method to prepare mixed powder.
2 granulating and drying
Dissolving polyvidone K30 in 60% ethanol to obtain wetting agent, adding the mixed powder, and making into soft material; granulating by using a 18-mesh screen, paving wet granules in a stainless steel plate, drying at 40 ℃ until the moisture content is 3-5% by drying in a hot air circulation manner, and thus obtaining dry granules, wherein the thickness of the wet granules cannot exceed 2 cm.
3 finishing of granules
Collecting the dry granules, and grading with 16 mesh sieve to obtain granules.
4 Total mixing
And adding the rest of crospovidone into the granules after finishing the granules, adding magnesium stearate, and performing total mixing operation to obtain a total mixed material.
5 tabletting
Loading a punch die on a tablet press, adjusting the loading amount, pressure and rotating speed by using particles, and tabletting for 1000 tablets (1.0 g/tablet), wherein the weight range of the tablets is controlled to be 0.97g +/-5 percent, so that the plain tablets are obtained. During the tabletting process, the operator checks the tablet weight every 15 minutes.
6 coating
And adding 50% ethanol into the coating premix to prepare a coating solution with the solid content of 10%. And (3) taking plain tablets, putting the plain tablets into a coating machine, starting the coating machine, preheating the plain tablets, then starting an exhaust fan and a spraying system, uniformly spraying coating liquid on the surfaces of the plain tablets, continuously blowing hot air at 40 ℃ for 5-10 minutes after the coating liquid is sprayed, then blowing cold air until the surfaces of the plain tablets reach room temperature, and taking out the coated tablets to obtain the coated tablets. The weight of the coating is increased by about 3 percent.
7 inner package
And (4) taking the inner packing material of the aluminum-aluminum package, debugging an inner packing machine, and carrying out aluminum-aluminum packaging according to 5 sheets/plate.
8 external packing
And taking the materials for external packaging such as product specifications, packaging boxes and the like, and carrying out external packaging to obtain the finished product.
9 inspection and warehousing
Sampling, checking and issuing a check report. And (4) handling warehousing procedures according to qualified inspection reports.
10 process requirements
The feeding to the inner package are all carried out in a 10 ten thousand grade clean area, and the outer package is carried out in a general production area.
EXAMPLE 2 preparation of nutrient composition for mid-pregnancy
2g of oxidoreductase (SOD), 1g of protease and the following other raw and auxiliary materials are adopted as the ferment:
Figure BDA0002300202980000091
Figure BDA0002300202980000101
the preparation method is the same as that of example 1.
Example 3 preparation of nutrient composition for mid-pregnancy enzyme 5g protease was used, and other raw and auxiliary materials were as follows:
Figure BDA0002300202980000102
Figure BDA0002300202980000111
the preparation method is the same as that of example 1.
EXAMPLE 4 Final product quality testing
Two panels of the finished package prepared in examples 1-3 were randomly picked, one panel sample was inspected at all, and the other panel was sealed and stored for future reference. Wherein, the sensory requirement accords with the requirement of table 1, the physical and chemical index accords with the requirement of table 2, the microorganism index accords with the requirement of table 3, and the content measurement of the functional components accords with the requirement of table 4. The detection results of the products all meet the requirements.
TABLE 1 sensory requirements
Figure BDA0002300202980000112
Figure BDA0002300202980000121
TABLE 2 physical and chemical indexes
Item Index (I) Detection method
Ash content% ≤65.0 GB 5009.4
Lead (Pb), mg/kg ≤2.0 GB 5009.12
Total arsenic (As), mg/kg ≤1.0 GB 5009.11
Total mercury (Hg), mg/kg ≤0.3 GB 5009.17
Disintegration time limit, min ≤60 Pharmacopoeia of the people's republic of China 2015 edition four parts
TABLE 3 microbiological indicators
Item Index (I) Detection method
Total number of colonies, CFU/g ≤30000 GB 4789.2
Coliform group, MPN/g ≤0.92 GB 4789.3 MPN counting method
Mold and Yeast, CFU/g ≤50 GB 4789.15
Staphylococcus aureus ≤0/25g GB 4789.10
Salmonella ≤0/25g GB 4789.4
TABLE 4 index of effective components
Figure BDA0002300202980000122
Figure BDA0002300202980000131
While embodiments of the invention have been disclosed above, it is not intended to be limited to the uses set forth in the specification and examples. It can be applied to all kinds of fields suitable for the present invention. Additional modifications will readily occur to those skilled in the art. Therefore, the invention is not to be limited to the specific details and embodiments shown and described herein, without departing from the general concept defined by the appended claims and their equivalents.

Claims (9)

1. The nutrient composition for the middle pregnancy is characterized by comprising the following raw materials in parts by weight:
2. the nutrient composition for mid-pregnancy as claimed in claim 1, which comprises the following raw materials in parts by weight:
Figure FDA0002300202970000012
3. the nutrient composition for mid-pregnancy according to claim 1 or 2, wherein the raw material further comprises 0-5 parts by weight of enzyme.
4. The mid-term pregnant nutrient composition of claim 3, wherein the enzyme is one or both of a protease and an oxidoreductase.
5. The nutrient composition for mid-pregnancy as claimed in claim 4, wherein it is mixed with pharmaceutically acceptable excipients to make tablet, granule or capsule.
6. The nutrient composition for mid-pregnancy as claimed in claim 5, wherein it is mixed with the following adjuvants in parts by weight to make into tablet:
Figure FDA0002300202970000021
7. the nutrient composition for mid-pregnancy as claimed in claim 6, wherein it is mixed with the following adjuvants in parts by weight to make into tablet:
Figure FDA0002300202970000022
Figure FDA0002300202970000031
8. the mid-pregnancy nutrient composition according to claim 6 or 7, which is prepared by a method comprising the steps of:
s1, premixing
Mixing 50% of the crospovidone in parts by weight with the dextrin in parts by weight, and mixing with the microcrystalline cellulose in parts by weight by an equivalent incremental method; then uniformly mixing the raw materials with the parts by weight by an equivalent incremental method to prepare mixed powder;
s2, granulating and drying
The povidone K30 in parts by weight is dissolved in 60% ethanol to be used as a wetting agent, and the mixed powder is added for wetting to prepare a soft material; granulating by using a 18-mesh screen, flatly paving wet granules in a stainless steel plate, wherein the thickness of the wet granules cannot exceed 2 cm, drying by hot air circulation at the temperature of 40 ℃ until the moisture is 3-5%, and preparing dry granules;
s3, straightening granules
Collecting the dry granules, and grading the granules through a 16-mesh sieve to prepare granules after grading;
s4 Total mixing
Adding the rest of crospovidone into the granules after finishing granules, adding the magnesium stearate in the parts by weight, and performing total mixing operation to obtain a total mixed material;
s5, tabletting
Loading a punch die on a tablet press, adjusting the loading amount, pressure and rotating speed by using particles, and tabletting to obtain plain tablets, wherein the weight range of the tablets is controlled to be 0.97g +/-5%;
s6 coating
Taking the coating premix, and adding 50% ethanol to prepare a coating solution with the solid content of 10%; and (3) taking the plain tablets, putting the plain tablets into a coating machine, preheating the plain tablets, uniformly spraying a coating solution on the surfaces of the plain tablets, continuously blowing hot air at 40 ℃ for 5-10 minutes after the coating solution is sprayed, blowing cold air to the surfaces of the plain tablets to reach room temperature, taking out the coated tablets, and obtaining the coated tablets, wherein the coating weight is increased by 2.85-3.15%.
9. Use of the mid-pregnancy nutrient composition according to any one of claims 1-7 as a nutritional substance in the mid-pregnancy of a pregnant woman.
CN201911218719.1A 2019-12-03 2019-12-03 Nutrient composition for middle pregnancy period and preparation method and application thereof Pending CN110720631A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1778199A (en) * 2004-11-24 2006-05-31 王维义 Nutrient for pregnant woman and delivery woman
CN101485693A (en) * 2009-02-10 2009-07-22 王维义 Nutriment for pregnant and lying-in women
CN104382934A (en) * 2013-08-19 2015-03-04 宣城柏维力生物工程有限公司 Multivitamin tablet for pregnant women
CN107455758A (en) * 2017-08-11 2017-12-12 步源堂生物科技有限公司 A kind of pregnant woman supplements the health products of multivitamin and mineral matter
CN107853708A (en) * 2017-10-25 2018-03-30 太和县三九药业有限公司 A kind of pregnant woman, which uses, promotes foetus health development nutrition replenishers and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1778199A (en) * 2004-11-24 2006-05-31 王维义 Nutrient for pregnant woman and delivery woman
CN101485693A (en) * 2009-02-10 2009-07-22 王维义 Nutriment for pregnant and lying-in women
CN104382934A (en) * 2013-08-19 2015-03-04 宣城柏维力生物工程有限公司 Multivitamin tablet for pregnant women
CN107455758A (en) * 2017-08-11 2017-12-12 步源堂生物科技有限公司 A kind of pregnant woman supplements the health products of multivitamin and mineral matter
CN107853708A (en) * 2017-10-25 2018-03-30 太和县三九药业有限公司 A kind of pregnant woman, which uses, promotes foetus health development nutrition replenishers and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
吉林省食品安全标准网: "润可欣牌钙铁锌硒维生素A维生素B1维生素B2维生素B6烟酸叶酸维生素C泛酸片（孕妇）", 《HTTPS://WWW.JLFSSTD.NET/SEARCHDB.CGI?PAGE=3&KEY=%BA%EC%CE%E5%CE%B6》 *

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Application publication date: 20200124