CN107455758A - A kind of pregnant woman supplements the health products of multivitamin and mineral matter - Google Patents

A kind of pregnant woman supplements the health products of multivitamin and mineral matter Download PDF

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Publication number
CN107455758A
CN107455758A CN201710684299.0A CN201710684299A CN107455758A CN 107455758 A CN107455758 A CN 107455758A CN 201710684299 A CN201710684299 A CN 201710684299A CN 107455758 A CN107455758 A CN 107455758A
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China
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health products
vitamin
obtains
multivitamin
raw material
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李金星
张伟铖
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Step Yuantang Biotechnology Co Ltd
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Step Yuantang Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses the health products that a kind of pregnant woman supplements multivitamin and mineral matter, contain following weight raw material in 1000 1050g health products：1.337 2.0g vitamine A acetates, 0.5 1.0g vitamin Ds3, 0.42 0.56g Thiamin mononitrates, 0.425g riboflavin, 0.475g puridoxine hydrochlorides, 25 32.5g vitamin Cs, 0.125 0.15g folic acid, 3.75 4.2g niacinamide, 1.65 1.915g calcium pantothenates, 499.97 749.99g calcium carbonate, 12.25 28.6g ferrous fumarates, 20.28 37.59g zinc gluconates, 63.3 179.7g starch, 0 94g dextrin, 92 118g sucrose, 10 12g carboxyrnethyl starch sodiums, 10 10.5g magnesium stearates, 20 21g hydroxypropyl methylcelluloses.

Description

A kind of pregnant woman supplements the health products of multivitamin and mineral matter
Technical field
The present invention relates to a kind of health products, and in particular to and a kind of pregnant woman supplements the health products of multivitamin and mineral matter, Fragrant board multivitamin several mineral materials piece in October is named as again, belongs to field of health care products.
Background technology
Nutrition is the physically and mentally healthy material base of human body.With the development of modern medicine and nutrition, more and more grind Study carefully and show, there is relation is promoted between perfect meals and health, improve some essential nutrients and other compositions in meals Be advantageous to keep or promote health.The women colony special as one, one crude drug experience the menstrual cycle, edge design, Multiple special periods such as climacteric, body also have greatly changed therewith to the requirement of nutrient, so, women is to battalion Support and be known as special needs.Edge design women increases than usual due to a variety of physiological changes to the requirement of each nutrient Add.Gestation physiology " adjustment " process complicated as one, women is in gestation, except the nutrient required for maintenance own health Outside, all nutriments needed for embryo growth and development are also supplied, make material preparation for childbirth and lactication.Thus rational battalion The health for being not only directly connected to pregnant and lying-in women itself is supported, is also related to fetus or even the sound development of baby.
The 1970s suffers from serious osteomalacia in one of India investigation display, because pregnant woman is deficient in vitamin D Disease, its baby also twitch for congenital rickets or hypocalcemia.A report that micronutrient Action Group is delivered recently Middle title, Kenya there are about that 1000 pregnant woman are dead because of hypoferric anemia in pregnant and perinatal period, and about half Kenya women takes the photograph zinc every year Deficiency.
Many he result of investigation show that quite a few pregnant woman of China deposits in the intake of vitamin and mineral In deficiency.A large amount of cards are it is thought that the asiderosis of early pregnancy is relevant with premature labor and low birth weight, and suffers from hypoferric anemia Pregnant woman is poor to the resistivity of infectious diseases, maternal martality rate increase.Discovered in recent years, China's pregnant woman anemia illness rate reach 34.4%-65.9%, hypoferric anemia account for 68.5%.According to the investigation in Fujian, 83.9% pregnant woman suffers from asiderosis in various degree Disease.Shanghai pregnant woman's asiderosis incidence of disease is more than 60%.Yunnan pregnant woman, second trimester prevalence of anemia 68.50%, pregnant late period be 58.33%.Found in the Nutritive status inquisition to Yuxi pregnant women, except vitamin c intake reach more than DNA it Outside, it is too low to be not up to the nutrient intake such as DNA, iron, calcium, carrotene, vitamin B2 for other vitamin and minerals. The investigation result of Shanghai City pregnant women nutrient intake is shown：The intake of iron, zinc, vitamin A and vitamin B1 is less than RDA person accounts for more than half.Show still have in the women of child-bearing age of poor rural indivedual bright in the investigation result of 14 provinces and cities recently Aobvious vitamine A deficiency, such as yctalopia.The gestational period D that is deficient in vitamin can cause a variety of metabolic calcium disorders of mother and baby, including new life Malacosteon occurs for youngster's hypocalcemia and tetany, baby's enamel hypoplasia and mother.Folic acid intake deficiency or Underfed pregnant woman is often accompanied by a variety of bad pregnancy outcomes, including born low birth weight children, abruptio placentae and nerve channel Deformity etc..
Most of nutrients, which also fail to reach, to be found to the dietary survey of wet nurse phase women according to some scholars of recent year To RDA standards.Someone is to the Chaoyang in Liaoning, the Ha Er ice in Heilungkiang, the Liaocheng in Shandong, the Wuzhong in Ningxia, the granary in Jiangsu, lake 7 areas such as the Wuhan in north, the Nanning in Guangxi have carried out Nutritional Status of Lactating Mothers investigation, as a result find in the mothers' diet of different regions It is more inadequate that most nutrition are known as different degrees of deficiency, especially calcium, zinc, the intake of vitamin B2, in addition, vitamin C etc. It is relatively low in northern 4 regional intakes.There is the dietary survey discovery to Guiyang Suburb wet nurse, calcium, riboflavin only account for DNA 22- 66% and 38-57%, thiamine, nicotinic acid only up to the 70% of RDA.Have and the wet nurse in Qinling-Bashan mountainous area 101 6 months is carried out Dietary survey, find various nutrients in addition to vitamin E and vitamin C less than the 70% of RDA, wherein vitamin A, B2, Cu, Zn point Not Wei RDA 15.19%, 30.48%, 17.43%, 43.35%.There is the dietary survey to Chaoyang area wet nurse, find In addition to heat energy and iron, most of nutrients are less than supply standard in various degree.In addition, also have investigation to find, Jinan City's breast Female meals zinc intake only reaches RNI 84%, and the intake of calcium is substantially relatively low, only accounts for the 62.5% of RNI, vitamin B1 is taken the photograph Enter amount only accounts for RNI 72.2%, vitamin A, ascorbic intake are also not reaching to RNI requirement.And all previous extensive In national childhood underweight generaI investigation, birth weight is close with developed country, but develops then obvious fall behind the 4-6 months.And have Report, China's infant nutrition anaemia, the incidence of disease of rickets are up to 30% or so.
China there are about 20,000,000 women pregnancy every year, and have the baby due of about the same quantity, and close to identical number Mother of amount is breast-feeding.Therefore, pregnant woman, wet nurse are a very big special populations, the nutrition of this crowd and health status Quality directly affects the development in an all-round way of the muscle power of fetus, baby, teenager or even adult, intelligence.Document report both domestic and external refers to Go out, keratomalacia can occur for the A if pregnant woman is deficient in vitamin, neonate；Be deficient in vitamin B6, and vitamin B6 occurs in neonate Property twitch, or even there is premature labor and stillborn foetus；Fetal anomaly can be caused by lacking folic acid, and birth weight declines, indivedual pregnant woman Placental abruption even occurs；Be deficient in vitamin D, not only makes pregnant woman itself osteomalacia, and skeleton development obstacle also occurs in fetus. If in gestation supplement multivitamin, the fitness of mother and fetus can all strengthen, and can reduce and prevent and be congenital Property defect.A report of the Center for Disease Control also indicates that pregnant woman's supplement, which takes vitamin, can make to suffer from cerebral deficits baby Risk reduce half, therefore, extra-nutrition element reasonable to pregnant woman, in appropriate amount is necessary.
And wet nurse's phase women nutritional reservoir for being consumed when on the one hand progressively compensating gestation and childbirth, promote organ and each The recovery of systemic-function；On the other hand lactation, nurture baby are also wanted.Milk contains whole required for baby in 4-6 months Nutrient and bioactive substance, it is baby's optimal natural food and beverage, and the nutrition of wet nurse is the material of galactosis Basis, galactosis amount and nutritional ingredient are influenceed by Nutritional Status of Lactating Mothers, diet etc., especially work as nutrient intake mobility scale Influence to become apparent from when larger.Breast milk is as the initial 4-6 middle of the month sole nutrition of baby's life usually source, and the content of its nutrient is just It is particularly important.Therefore, the rational diet nutritional of wet nurse phase women is to guarantee own health and the normal growth and development of baby It is very important.
At present, the nutrient compensation process of nutrition educational circles accreditation mainly has dietary adjustments, takes the class of replenishers two.But Because the vitamin contained in diet is limited, and because of food processing, the excessively factors such as culinary art and irrational eating habit Limitation, ordinary meal is difficult to the needs for meeting nutrition general equilibrium, taking vitamin, mineral supplements turns into people Diet necessary complement.And nutrient prime replenisher is without for the purpose of providing energy by replenishing vitamins, mineral matter Product, it is complementary diets supply deficiency that it, which is acted on, prevention nutritional deficiency and reduces the danger that some chronic degenerative diseases occur It is dangerous.It is broadly divided into vitamins nutritious supplementary pharmaceutical, mineral nutrient supplement and composite nutrient component extender.From benefit From the point of view of the vitamin and the species of mineral matter that fill, wherein vitamin includes vitamin A, vitamin B, vitamin C, vitamin D, dimension Raw plain E, folic acid and beta carotene, mineral matter include calcium, zinc, selenium, magnesium, manganese.In composite nutrient element replenishers, mainly with more Kind of vitamin and mineral matter are supplement object, but the suitable crowd of replenishers is owner, without specific aim.
The content of the invention
The technical problems to be solved by the invention are to be directed to the deficiencies in the prior art, and provide a kind of pregnant woman's supplement The health products of multivitamin and mineral matter, fragrant board multivitamin several mineral materials piece in October is named as again；It is according to pregnancy Women needs in the physiological change of different pregnancy phases, the special identity and physiological change of wet nurse phase women to the difference of various nutrients Will, by rational recipe determination, nutrients formula is designed and refined, be the woman of pregnant early stage, second trimester, pregnant late period and wet nurse's phase The nutrient prime replenisher that female specially designs, the healthcare function of supplement multivitamin and mineral matter is realized, there is stronger be directed to Property.
To achieve these goals, the present invention adopts the following technical scheme that：
A kind of pregnant woman supplements the health products of multivitamin and mineral matter, by vitamin premix, mineral substance premix, auxiliary Material is through sieving, mixing, softwood processed, granulation, drying, whole grain, total mixed, tabletting, art for coating are prepared, it is characterised in that：
Described vitamin premix includes vitamine A acetate, vitamin D3, Thiamin mononitrate, riboflavin, hydrochloric acid pyrrole Tremble alcohol, vitamin C, folic acid, niacinamide, calcium pantothenate；
Described mineral substance premix is calcium carbonate, ferrous fumarate, zinc gluconate；
Described auxiliary material includes starch, dextrin, sucrose, carboxyrnethyl starch sodium, magnesium stearate, hydroxypropyl methylcellulose；
Contain the raw material of following weight in 1000-1050g health products：
In above-mentioned technical proposal, the raw material of following weight is preferably comprised in described 1000g health products：
The health products are mainly that pregnant early stage women supplements multivitamin and mineral matter.Pregnant early stage refers to women's pregnancy First 3 months (i.e. preceding 12 weeks) is fetus from embryonated egg through division, implantation, the stage up to forming human body.The cell of fetus point Change, orga- nogenesis occur mainly in pregnant early stage, wherein especially the rapidest with the development of brain and nervous system；Meanwhile pregnant early stage It is the period that adaptability physiological change occurs in parent.Pregnant woman often occurs partial eclipse, Nausea and vomiting, is off one's feed during this period, very To bedfast morning sickness, started more than 6 weeks greatly, Lock-out after 13 weeks, but a small number of pregnant woman vomiting is violent, sends out repeatedly Make, parent dehydration or more serious consequence can be caused.Therefore, the suitable meals of pregnant woman and nutrition are arranged during this, to pregnant Woman's health and development of fetus are particularly important.
In above-mentioned technical proposal, the raw material of following weight is preferably comprised in described 1000g health products：
The health products are mainly pregnant women supplement multivitamin and mineral matter.Second trimester refers to women's pregnancy 4- 6 months, i.e., 13-28 weeks, it is the rapid developmental stage of fetus；Bone, tooth, face and the four limbs of fetus all have begun to shape, Brain is further developed, while the uterus of pregnant woman, placenta and breast are also developed rapidly；In this period, the pregnancy reaction of pregnant woman Mitigation, appetite recover, appetite increase, to the requirement abruptly increase of various nutrients；Now, the ore deposits such as abundant calcium, iron, zinc should be provided Material and vitamin, with meet fetal bone, dental growth development needs and maternal nutrition demand, and be advantageous to prevent pregnant woman There are the deficiency diseases such as alimentary anemia, osteomalacia and nutritional edema.
In above-mentioned technical proposal, the raw material of following weight is preferably comprised in described 1050g health products：
The health products are mainly that pregnant late period women supplements multivitamin and mineral matter.In pregnant late period, refer to that women is pregnant 7-9 months, it is i.e. pregnant 29-40 weeks, be the fetal growth most fast stage.Fetus in-vivo tissue, organ increase rapidly, brain cell point Split propagation to accelerate, bone starts calcification, and body weight is about connatae 70%, while pregnant woman uterus increase, and mammogenesis is speeded, base Plinth metabolic rate increases to peak.This stage either parent or fetus, to various nutrients especially vitamin and mineral Requirement substantially increase, once diet nutrient insufficiency of intake, can directly affect growing for fetus.Pregnant late period should be by it Feature arranges diet, such as ensures enough calcareous, to meet that the increase of the reserve of parent calcium and fetus tooth bone calcification accelerate, one Denier is insufficient, may result in parent and osteomalacia occurs, jawbone and deformity teeth, asymmetry etc. occur for fetus；Supplement dimension simultaneously Plain D is given birth to promote the absorption of calcium；Also need to more intake B family vitamins, with avoid parent due to a lack of and produce vomiting, burnout, flesh It is powerless, uterine contractile during childbirth is influenceed, causes prolonged labor, childbirth difficult.
In above-mentioned technical proposal, the raw material of following weight is preferably comprised in described 1050g health products：
The health products are mainly that wet nurse's phase women supplements multivitamin and mineral matter.Wet nurse's phase women on the one hand will be progressively The nutritional reservoir consumed when compensation gestation and childbirth, promotes the recovery of organ and each systemic-function；On the other hand also to secrete Milk, nurture baby.Milk contains whole nutrients and bioactive substance required for baby in 4-6 months, is that baby is optimal Natural food and beverage, and the nutrition of wet nurse is the material base of galactosis, and galactosis amount and nutritional ingredient are by wet nurse Nutrition condition, diet etc. influence, and especially influence to become apparent from when nutrient intake mobility scale is larger.Further, since people The normal development of intelligence and brain tissue is closely related, and the differentiation of human brain cell and formation are mainly 2 after birth in pregnant 10 weeks Within year, wherein again with particularly important within 1 years old.Normal infant is original 3 times in the increase of 1 yearling weight, and height increase is Originally 2 times, while organ dysfunction and body composition also show the change of significant development, the fast-growth hair of baby Educate, it is added special nutritional need on the basis of originally higher maintenance nutritional requirements.Breast milk conduct Usually source, the content of its nutrient are just particularly important the initial 4-6 middle of the month sole nutrition of baby's life.Therefore, wet nurse's phase The rational diet nutritional of women is very important to the normal growth and development for ensureing own health and baby.
In above-mentioned technical proposal, described vitamine A acetate, its vitamin A content is 500000IU/g；Described dimension Raw plain D3, its vitamin D3Content is 100000IU/g.
In above-mentioned technical proposal, described health products are prepared by following methods, and flow chart is as shown in Figure 1：
(1) sieve：The vitamin premix of the ratio, mineral substance premix, starch, dextrin are crossed into 80 mesh sieves, sucrose 80 mesh sieves are crossed after crushing, carboxyrnethyl starch sodium, magnesium stearate cross 100 mesh sieves, obtain the fine powder of each raw material respectively；
(2) mix：The starch dust, dextrin fine powder, sucrose fine that are obtained in step (1) are well mixed, mixed Powder A；Mixed powder A is well mixed with mineral substance premix fine powder again, obtains mixed powder B；
(3) softwood processed：Mixed powder B in step (2) is well mixed with 70% ethanol, obtains softwood；
(4) pelletize：The softwood that step (3) obtains is crossed into 18 mesh sieves, obtains wet granular；
(5) dry：The wet granular that step (4) is obtained is dried at 60-70 DEG C again, obtains dry particl；
(6) whole grain：The dry particl that step (5) obtains is crossed into 18 mesh sieves, obtains particle；
(7) it is total mixed：The vitamin premix fine powder that step (1) is obtained, the particle obtained with step (6) carry out equivalent and passed Increase mixing, obtain mixture；Add carboxyrnethyl starch sodium fine powder, magnesium stearate fine powder that step (1) obtains to be well mixed, obtain Total mixture；
(8) tabletting：The total mixture that step (7) is obtained carries out tabletting, controls plate core weight 0.98g/ piece -1.029g/ pieces, Obtain label；
(9) it is coated：The hydroxypropyl methylcellulose of the ratio is dissolved with 70% ethanol, prepares coating solution；Again with coating The label film coating that liquid obtains to step (8), make coating tablet weight 1g/ piece -1.05g/ pieces, it is described guarantor to obtain coating tablet Strong product；
(10) inner packing：Dress is wrapped inside in above-mentioned coating tablet, inner packaging material should meet relevant national standard；
(11) by product after inner packing, through outer packing, quality inspection warehousing after passing.
Step (1)-(10) are carried out in 100,000 clean areas, and the production operation of all process steps is entered in strict accordance with GMP OK, with ensure the hygiene quality guarantee of product reach company standard according to GB16740-1997 requirement.
In technical solution of the present invention, the nutrient and effect that contain in each raw material are shown in Table 1：
Table 1：The effect of raw material, acts on
The starch in auxiliary material, it is the most frequently used auxiliary material of tablet in technical solution of the present invention, it is stable in the air, with majority Material does not work, the filler commonly used for tablet, and has calving disaggregation.Dextrin, the fillers for being used as tablet, has concurrently viscous more The effect of mixture, often shared with starch, sucrose, filler is used as in the present invention.Sucrose, is the excellent diluent of tablet, and has Flavoring and adhesive effect；As diluent, pelletization is easily controlled, can reduce tablet pit, it is loose phenomena such as, and make The hardness increase of tablet, any surface finish are attractive in appearance.Carboxyrnethyl starch sodium, there is good mobility, dilatancy and compressibility, be tablet Excellent disintegrant.Magnesium stearate, have it is good lubricate, be anti-stick and help stream to act on, sticking and frictional force can be reduced, made unilateral It is smooth, attractive in appearance.Hydroxypropyl methylcellulose, to heat, light, it is wet have suitable stability, and filming performance is good, the bag as the present invention The coating agent of colorless film clothing.
In technical solution of the present invention, described health products, orally, 2 times a day, 1 tablet once.
The advantages of technical solution of the present invention, is：
(1) present invention according to pregnant woman in different pregnancy phases, the physiological change of the women of wet nurse's phase to various nutrients Difference needs, and by rational recipe determination, nutrients formula is designed and refined, and is designed for pregnant women, wet nurse's phase women Serial nutritious plain replenishers product；It is that the nutrient designed exclusively for pregnant early stage, second trimester, pregnant late period, wet nurse's phase women supplements Agent, it is intended to be reached for pregnant early stage, second trimester, pregnant late period, women's supplement multivitamin of wet nurse's phase and the healthcare function of mineral matter, With stronger specific aim.
(2) present invention is composite nutrient element replenishers, i.e. multivitamin class and several mineral materials class nutrient supplement Agent, the collocation between vitamin and mineral matter in the present invention are more conducive to the absorption of nutrient, and the supplement that reaches that can be good is imitated Fruit.
(3) present invention is according to the special requirement of different pregnancy phases, the physilogical characteristics of wet nurse phase women to various nutrients, finally 9 kinds of vitamins and 3 kinds of mineral matters have been selected to carry out compatible use in formula, to be reached for different pregnancy phases, wet nurse's phase women supplements Multivitamin and mineral matter, the purpose improved health conditions.
(5) raw material vitamin premix of the present invention, mineral substance premix are solid powder, vitamin premix dosage phase To less, there is good mobility and compressibility；But because some vitamin meets damp and hot unstable, quality to product and stably Property can have a certain impact；And mineral substance premix dosage is larger, and it is relatively stable.Therefore, according to the property of raw material and Dosage, after mineral substance premix is mixed pelleting with suitable auxiliary material by the present invention, then mix and pressed with vitamin premix Piece is coated again.
(6) present invention reduces fine powder absorption and powder is flown upward, avoid slice, thin piece pine from splitting, protect to increase the mobility of material Card tabletting, coating be smoothed out being molded with slice, thin piece after character is attractive in appearance, reliable in quality, the present invention is coated again from pelleting tabletting Technique prepared.Tablets have advantages below：Dosage is accurate；Dissolution rate and bioavilability are good compared with pill；Clothes With, carry, transport etc. it is more convenient；Cost is cheap, mechanization production is convenient, and sanitary condition is easily controlled；Again due to this product portion Divide raw material easily to be influenceed by air, humidity, select film coating, that is, ensure that the stabilization of product quality amount, make product appearance again It is attractive in appearance, easily receive for eater.
Brief description of the drawings：
Fig. 1 is the process chart of health products preparation method of the present invention；
Wherein：Represent 100,000 clean areas, that is to say, that it is clean that the dashed rectangle in bright book accompanying drawing represents 100,000 Area.
Embodiment
The embodiment of technical solution of the present invention is described in detail below, but the present invention is not limited in following description Hold：
Equipment is used in the embodiment of the present invention is：
Vortex oscillation sieve (model ZS-350), trough type mixing machine (CH-200), multidirectional three-dimensional motion mixer (SYH- 200), oscillating granulator (YK-160), HighefficientFluidbeddrier (GFG-120), high speed tablet press (ZPT-16), sugar coating machine (BY-600)。
Raw material, the auxiliary material used in the embodiment of the present invention be：
Vitamine A acetate, vitamin D3, Thiamin mononitrate, riboflavin, puridoxine hydrochloride, vitamin C, folic acid, nicotinoyl Amine, calcium pantothenate, calcium carbonate, ferrous fumarate, zinc gluconate and starch, dextrin, sucrose, carboxyrnethyl starch sodium, magnesium stearate, hydroxyl Third methylcellulose.
In the embodiment of the present invention, the raw material of following weight is contained in 1000-1050g health products：
It is prepared by following methods：
(1) sieve：The vitamin premix of the ratio, mineral substance premix, starch, dextrin are crossed into 80 mesh sieves, sucrose 80 mesh sieves are crossed after crushing, carboxyrnethyl starch sodium, magnesium stearate cross 100 mesh sieves, obtain the fine powder of each raw material respectively；
(2) mix：The starch dust, dextrin fine powder, sucrose fine that are obtained in step (1) are well mixed, mixed Powder A；Mixed powder A is well mixed with mineral substance premix fine powder again, obtains mixed powder B；
(3) softwood processed：Mixed powder B in step (2) is well mixed with 70% ethanol, obtains softwood；
(4) pelletize：The softwood that step (3) obtains is crossed into 18 mesh sieves, obtains wet granular；
(5) dry：The wet granular that step (4) is obtained is dried at 60-70 DEG C again, obtains dry particl；
(6) whole grain：The dry particl that step (5) obtains is crossed into 18 mesh sieves, obtains particle；
(7) it is total mixed：The vitamin premix fine powder that step (1) is obtained, the particle obtained with step (6) carry out equivalent and passed Increase mixing, obtain mixture；Add carboxyrnethyl starch sodium fine powder, magnesium stearate fine powder that step (1) obtains to be well mixed, obtain Total mixture；
(8) tabletting：The total mixture that step (7) is obtained carries out tabletting, controls plate core weight 0.98g/ piece -1.029g/ pieces, Obtain label；
(9) it is coated：The hydroxypropyl methylcellulose of the ratio is dissolved with 70% ethanol, prepares coating solution；Again with coating The label film coating that liquid obtains to step (8), make coating tablet weight 1g/ piece -1.05g/ pieces, obtain coating tablet；
(10) inner packing：Dress is wrapped inside in above-mentioned coating tablet, inner packaging material should meet relevant national standard；
(11) by product after inner packing, through outer packing, quality inspection warehousing after passing.
Step (1)-(10) are carried out in 100,000 clean areas, and the production operation of all process steps is carried out according to GMP.
The conversion between each raw material and nutrient therein in the embodiment of the present invention is as shown in table 2：
Table 2：Conversion between raw material, nutrient
The present invention is illustrated with reference to specific embodiment：
Embodiment 1：
A kind of pregnant woman supplements the health products of multivitamin and mineral matter, is prepared by the raw material in table 3, raw material amounts to 1000g, 1000, wherein label 0.98g/ pieces, coating tablet 1g/ pieces are made；It is named as the fragrant a variety of ore deposits of board multivitamin in October Material piece (pregnant early stage).The proportioning for containing raw material per tablet health product is shown in Table 3, per tablet health product in nutrient according to table 2 conversion Coefficient conversion, concrete outcome are shown in Table 3：
Table 3：The formula and nutrient content for the health products that embodiment 1 obtains
Nutrients formula reduced value in each raw material in table 3, only theoretical values；The embodiment of the present invention 1 is obtained Fragrant board multivitamin several mineral materials piece in October (pregnant early stage) is delivered to sanitary analysis test center of Shandong University and detected, respectively Content detection standard, the testing result of nutrient are as follows：
Survey report homepage
Determined by above-mentioned testing result：The fragrant board multivitamin several mineral materials piece in October (pregnant early stage) of the present invention, often Piece contains functional component and content：μ g of vitamin A 236, vitamin D31.2 μ g, vitamin B10.37mg, vitamin B2 0.37mg, vitamin B60.46mg, vitamin C 19mg, μ g of folic acid 118, niacinamide 3.3mg, pantothenic acid 1.6mg, calcium 178mg, Iron 3.9mg, zinc 2.8mg.
It is big that the fragrant board multivitamin several mineral materials piece in October (pregnant early stage) that the embodiment of the present invention 1 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, the examination criteria of the stability of each nutrient, testing result are as follows：
Survey report homepage
It is big that the fragrant board multivitamin several mineral materials piece in October (pregnant early stage) that the embodiment of the present invention 1 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, the hygienic examination criteria of each nutrient, testing result are as follows：
Survey report homepage
Embodiment 2：
A kind of pregnant woman supplements the health products of multivitamin and mineral matter, is prepared by the raw material in table 4, raw material amounts to 1000g, 1000, wherein label 0.98g/ pieces, coating tablet 1g/ pieces are made；It is named as the fragrant a variety of ore deposits of board multivitamin in October Material piece (second trimester).The proportioning for containing raw material per tablet health product is shown in Table 4, per tablet health product in nutrient according to table 2 conversion Coefficient conversion, concrete outcome are shown in Table 4：
Table 4：The formula and nutrient content for the health products that embodiment 2 obtains
Nutrients formula reduced value in each raw material in table 4, only theoretical values；The embodiment of the present invention 2 is obtained Fragrant board multivitamin several mineral materials piece (second trimester) was delivered to sanitary analysis test center of Shandong University and detected October, respectively Content detection standard, the testing result of nutrient are as follows：
Survey report homepage
Determined by above-mentioned testing result：The fragrant board multivitamin several mineral materials piece (second trimester) in October of the present invention, often Piece contains functional component and content：μ g of vitamin A 284, vitamin D32.1 μ g, vitamin B10.33mg, vitamin B2 0.46mg, vitamin B60.46mg, vitamin C 31mg, μ g of folic acid 120, niacinamide 3.3mg, pantothenic acid 1.6mg, calcium 211mg, Iron 6.4mg, zinc 4.0mg.
It is big that the fragrant board multivitamin several mineral materials piece (second trimester) in October that the embodiment of the present invention 2 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, Detection of Stability standard, the testing result of each nutrient are as follows：
Survey report homepage
It is big that the fragrant board multivitamin several mineral materials piece (second trimester) in October that the embodiment of the present invention 2 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, Hygienic determination standard, the testing result of each nutrient are as follows：
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Embodiment 3：
A kind of pregnant woman supplements the health products of multivitamin and mineral matter, is prepared by the raw material in table 5, raw material amounts to 1050g, 1000, wherein label 1.029g/ pieces, coating tablet 1.05g/ pieces are made；It is more to be named as October fragrant board multivitamin Kind Centrum (pregnant late period).The proportioning for containing raw material per tablet health product is shown in Table 5, and nutrient is according to table 2 in every tablet health product Conversion coefficient converts, and concrete outcome is shown in Table 5：
Table 5：The formula and nutrient content for the health products that embodiment 3 obtains
Nutrients formula reduced value in each raw material in table 5, only theoretical values；The embodiment of the present invention 3 is obtained Fragrant board multivitamin several mineral materials piece in October (pregnant late period) is delivered to sanitary analysis test center of Shandong University and detected, respectively Content detection standard, the testing result of nutrient are as follows：
Survey report homepage
Determined by above-mentioned testing result：The fragrant board multivitamin several mineral materials piece in October (pregnant late period) of the present invention, often Piece contains functional component and content：μ g of vitamin A 224, vitamin D31.9 μ g, vitamin B10.27mg, vitamin B2 0.44mg, vitamin B60.47mg, vitamin C 33mg, μ g of folic acid 126, niacinamide 3.4mg, pantothenic acid 1.6mg, calcium 260mg, Iron 9.5mg, zinc 4.1mg.
It is big that the fragrant board multivitamin several mineral materials piece in October (pregnant late period) that the embodiment of the present invention 3 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, Detection of Stability standard, the testing result of each nutrient are as follows：
Survey report homepage
It is big that the fragrant board multivitamin several mineral materials piece in October (pregnant late period) that the embodiment of the present invention 3 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, Hygienic determination standard, the testing result of each nutrient are as follows：
Survey report homepage
Embodiment 4：
A kind of pregnant woman supplements the health products of multivitamin and mineral matter, is prepared by the raw material in table 6, raw material amounts to 1050g, 1000, wherein label 1.029g/ pieces, coating tablet 1.05g/ pieces are made；It is more to be named as October fragrant board multivitamin Kind Centrum (wet nurse's phase).The proportioning for containing raw material per tablet health product is shown in Table 6, and nutrient is according to table 2 in every tablet health product Conversion coefficient converts, and concrete outcome is shown in Table 6：
Table 6：The formula and nutrient content for the health products that embodiment 4 obtains
Nutrients formula reduced value in each raw material in table 6, only theoretical values；The embodiment of the present invention 4 is obtained Fragrant board multivitamin several mineral materials piece in October (wet nurse's phase) is delivered to sanitary analysis test center of Shandong University and detected, respectively Content detection standard, the testing result of nutrient are as follows：
Survey report homepage
Determined by above-mentioned testing result：The fragrant board multivitamin several mineral materials piece in October (wet nurse's phase) of the present invention, often Piece contains functional component and content：μ g of vitamin A 377, vitamin D32.0 μ g, vitamin B10.38mg, vitamin B2 0.31mg, vitamin B60.47mg, vitamin C 23mg, μ g of folic acid 118, niacinamide 3.6mg, pantothenic acid 1.7mg, calcium 262mg, Iron 6.2mg, zinc 5.3mg.
It is big that the fragrant board multivitamin several mineral materials piece in October (wet nurse's phase) that the embodiment of the present invention 4 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, Detection of Stability standard, the testing result of each nutrient are as follows：
Survey report homepage
It is big that the fragrant board multivitamin several mineral materials piece in October (wet nurse's phase) that the embodiment of the present invention 4 is obtained delivers to Shandong Learn sanitary analysis test center to be detected, Hygienic determination standard, the testing result of each nutrient are as follows：
Survey report homepage
Examples detailed above is technical concept and technical characterstic to illustrate the invention, can not limit the present invention's with this Protection domain.The equivalent transformation or modification that all essence according to the present invention is done, should all cover in protection scope of the present invention Within.

Claims (10)

1. a kind of pregnant woman supplements the health products of multivitamin and mineral matter, by vitamin premix, mineral substance premix, auxiliary material Through sieving, mixing, softwood processed, granulation, drying, whole grain, total mixed, tabletting, art for coating be prepared；It is characterized in that：
Described vitamin premix includes vitamine A acetate, vitamin D3, Thiamin mononitrate, riboflavin, puridoxine hydrochloride, Vitamin C, folic acid, niacinamide, calcium pantothenate；
Described mineral substance premix is calcium carbonate, ferrous fumarate, zinc gluconate；
Described auxiliary material includes starch, dextrin, sucrose, carboxyrnethyl starch sodium, magnesium stearate, hydroxypropyl methylcellulose；
Contain the raw material of following weight in 1000-1050g health products：
2. health products according to claim 1, it is characterised in that contain the raw material of following weight in 1000g health products：
3. health products according to claim 1, it is characterised in that contain the raw material of following weight in 1000g health products：
4. health products according to claim 1, it is characterised in that contain the raw material of following weight in 1050g health products：
5. health products according to claim 1, it is characterised in that contain the raw material of following weight in 1050g health products：
6. application of the health products in terms of multivitamin and mineral matter is supplemented for pregnant early stage women described in claim 2.
7. application of the health products in terms of multivitamin and mineral matter is supplemented for pregnant women described in claim 3.
8. application of the health products in terms of multivitamin and mineral matter is supplemented for pregnant late period women described in claim 4.
9. application of the health products in terms of multivitamin and mineral matter is supplemented for wet nurse's phase women described in claim 5.
10. the preparation method of the health products described in claim any one of 1-5, it is characterised in that comprise the following steps：
(1) sieve：The vitamin premix of the ratio, mineral substance premix, starch, dextrin are crossed into 80 mesh sieves, sucrose crushes 80 mesh sieves are crossed afterwards, and carboxyrnethyl starch sodium, magnesium stearate cross 100 mesh sieves, obtain the fine powder of each raw material respectively；
(2) mix：The starch dust, dextrin fine powder, sucrose fine that are obtained in step (1) are well mixed, obtain mixed powder A； Mixed powder A is well mixed with mineral substance premix fine powder again, obtains mixed powder B；
(3) softwood processed：Mixed powder B in step (2) is well mixed with 70% ethanol, obtains softwood；
(4) pelletize：The softwood that step (3) obtains is crossed into 18 mesh sieves, obtains wet granular；
(5) dry：The wet granular that step (4) is obtained is dried at 60-70 DEG C again, obtains dry particl；
(6) whole grain：The dry particl that step (5) obtains is crossed into 18 mesh sieves, obtains particle；
(7) it is total mixed：The vitamin premix fine powder that step (1) is obtained, the particle obtained with step (6) carry out equal increments and mixed Close, obtain mixture；Add carboxyrnethyl starch sodium fine powder, magnesium stearate fine powder that step (1) obtains to be well mixed, always mixed Compound；
(8) tabletting：The total mixture that step (7) is obtained carries out tabletting, controls plate core weight 0.98g/ piece -1.029g/ pieces, obtains Label；
(9) it is coated：The hydroxypropyl methylcellulose of the ratio is dissolved with 70% ethanol, prepares coating solution；Given again with coating solution The label film coating that step (8) obtains, make coating tablet weight 1g/ piece -1.05g/ pieces, it is described health care to obtain coating tablet Product；Obtained health products preserve after inner packing, outer packing, inspection, storage post processing.
CN201710684299.0A 2017-08-11 2017-08-11 A kind of pregnant woman supplements the health products of multivitamin and mineral matter Pending CN107455758A (en)

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CN109998111A (en) * 2019-04-19 2019-07-12 潍坊峡山荆卫生物科技有限公司 A kind of health food and preparation method thereof
CN110720631A (en) * 2019-12-03 2020-01-24 吉林省红五味生物技术有限公司 Nutrient composition for middle pregnancy period and preparation method and application thereof
CN110720632A (en) * 2019-12-03 2020-01-24 吉林省红五味生物技术有限公司 Nutrient composition for late pregnancy and preparation method and application thereof
CN110839898A (en) * 2019-12-03 2020-02-28 吉林省红五味生物技术有限公司 Nutrient composition for early pregnancy and preparation method and application thereof
CN110934302A (en) * 2019-11-13 2020-03-31 安徽全康药业有限公司 Vitamin mineral tablet for pregnant women
CN111053242A (en) * 2019-12-03 2020-04-24 吉林省红五味生物技术有限公司 Nutrient composition for lactation period and preparation method and application thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109998111A (en) * 2019-04-19 2019-07-12 潍坊峡山荆卫生物科技有限公司 A kind of health food and preparation method thereof
CN110934302A (en) * 2019-11-13 2020-03-31 安徽全康药业有限公司 Vitamin mineral tablet for pregnant women
CN110720631A (en) * 2019-12-03 2020-01-24 吉林省红五味生物技术有限公司 Nutrient composition for middle pregnancy period and preparation method and application thereof
CN110720632A (en) * 2019-12-03 2020-01-24 吉林省红五味生物技术有限公司 Nutrient composition for late pregnancy and preparation method and application thereof
CN110839898A (en) * 2019-12-03 2020-02-28 吉林省红五味生物技术有限公司 Nutrient composition for early pregnancy and preparation method and application thereof
CN111053242A (en) * 2019-12-03 2020-04-24 吉林省红五味生物技术有限公司 Nutrient composition for lactation period and preparation method and application thereof

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Application publication date: 20171212