CN111053242A - Nutrient composition for lactation period and preparation method and application thereof - Google Patents

Nutrient composition for lactation period and preparation method and application thereof Download PDF

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Publication number
CN111053242A
CN111053242A CN201911218862.0A CN201911218862A CN111053242A CN 111053242 A CN111053242 A CN 111053242A CN 201911218862 A CN201911218862 A CN 201911218862A CN 111053242 A CN111053242 A CN 111053242A
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lactation
weight
nutrient composition
parts
granules
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睢大筼
翟永信
董守光
姜国魏
姜世超
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Jilin Hongwuwei Biotechnology Co ltd
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Jilin Hongwuwei Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a nutrient composition for lactation, a preparation method and application thereof, wherein the composition comprises calcium carbonate, ferrous fumarate, zinc gluconate, copper gluconate, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid, vitamin K1, D-calcium pantothenate and D- α -tocopherol as raw materials, and auxiliary materials including microcrystalline cellulose, crospovidone, maltodextrin and the like.

Description

Nutrient composition for lactation period and preparation method and application thereof
Technical Field
The invention relates to the technical field of nutritional health products for lying-in women, in particular to a nutrient composition for lactation and a preparation method and application thereof.
Background
The puerperium refers to a period of time from the delivery of the placenta to the recovery of all organs of the parturient except for the mammary gland or the approximate normal non-pregnant state, and generally takes 6 weeks. The physiology and the psychology of women in puerperium are greatly changed. At this time, the lying-in woman mainly has a rest, especially has a rest in bed within 15 days after delivery, and has a good health care function, so that the system of the whole body organ, especially the reproductive organ, can be recovered as soon as possible, which is commonly called as 'sitting in the moon'. Women in puerperium are weak, have poor appetite and poor digestion and absorption capacity, and need to supplement energy and physical strength consumed by childbirth and supplement nutrition and heat penetrated by lactation. Breast milk is the best natural nutrient, and a scientific and reasonable nutrition plan can provide sufficient milk for babies. Therefore, the simple daily diet can not meet the dual nutritional requirements of the mother and the baby, and the nutritional health care product is needed to be supplemented in a targeted manner. However, the existing products in the market share one formula for four stages of pregnancy, and no lactation nutritional health-care product specially provided for the characteristics of a lying-in woman in a lactation period is provided.
Disclosure of Invention
The invention aims to provide a lactation nutrient composition aiming at the body recovery needs, the fetal development characteristics and the nutritional needs of lying-in women in the lactation period, and the lactation nutrient composition is an ideal health food for the lying-in women in the lactation period.
The technical scheme adopted by the invention for solving the technical problem is as follows:
a lactation nutrient composition comprises the following raw materials in parts by weight:
Figure RE-GDA0002412483680000011
Figure RE-GDA0002412483680000021
preferably, the lactation nutrient composition comprises the following raw materials in parts by weight:
Figure RE-GDA0002412483680000022
furthermore, the lactation nutrient composition also comprises 0-5 parts of enzyme by weight.
Wherein the ferment is one or two of protease and oxidoreductase.
Furthermore, the lactation nutrient composition is mixed with pharmaceutically acceptable auxiliary materials to be prepared into tablets, granules or capsules.
Preferably, the raw materials are mixed with the following auxiliary materials in parts by weight to prepare tablets:
Figure RE-GDA0002412483680000023
Figure RE-GDA0002412483680000031
more preferably, the composition is mixed with the following auxiliary materials in parts by weight to prepare a tablet:
Figure RE-GDA0002412483680000032
the invention also provides the lactation nutrient composition, and the preparation method comprises the following steps:
s1, premixing
Mixing 50% of the crospovidone in parts by weight with the dextrin in parts by weight, and mixing with the microcrystalline cellulose in parts by weight by an equivalent incremental method; then uniformly mixing the raw materials with the parts by weight by an equivalent incremental method to prepare mixed powder;
s2, granulating and drying
The povidone K30 in parts by weight is dissolved in 60% ethanol to be used as a wetting agent, and the mixed powder is added for wetting to prepare a soft material; granulating by using a 18-mesh screen, flatly paving wet granules in a stainless steel plate, wherein the thickness of the wet granules cannot exceed 2 cm, drying by hot air circulation at the temperature of 40 ℃ until the moisture is 3-5%, and preparing dry granules;
s3, straightening granules
Collecting the dry granules, and grading the granules through a 16-mesh sieve to prepare granules after grading;
s4 Total mixing
Adding the rest of crospovidone into the granules after finishing granules, adding the magnesium stearate in the parts by weight, and performing total mixing operation to obtain a total mixed material;
s5, tabletting
Loading a punch die on a tablet press, adjusting the loading amount, pressure and rotating speed by using particles, and tabletting to obtain plain tablets, wherein the weight range of the tablets is controlled to be 0.97g +/-5%;
s6 coating
Taking the coating premix, and adding 50% ethanol to prepare a coating solution with the solid content of 10%; and (3) taking the plain tablets, putting the plain tablets into a coating machine, preheating the plain tablets, uniformly spraying a coating solution on the surfaces of the plain tablets, continuously blowing hot air at 40 ℃ for 5-10 minutes after the coating solution is sprayed, blowing cold air to the surfaces of the plain tablets to reach room temperature, taking out the coated tablets, and obtaining the coated tablets, wherein the coating weight is increased by 2.85-3.15%.
In addition, the invention also provides application of the lactation nutrient composition as a nutrient substance in the lactation period of the lying-in women. Specifically, the eating amount and the eating method are as follows: it is taken 2 times daily, 1 tablet each time, with warm water.
In the technical scheme, calcium carbonate, ferrous fumarate, zinc gluconate, copper gluconate, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid, VK1, D-calcium pantothenate and D- α -tocopherol are scientifically prepared, because:
the daily calcium intake of lactation women is preferably 1300-1500 mg; insufficient milk calcium can lead to rickets in the newborn. Furthermore, pregnancy and lactation can affect bone calcium metabolism in women, resulting in decreased bone density. Calcium supplementation by food alone is not sufficient, and only about 600mg of calcium is available in the diet, and therefore additional supplementation is required. Puerperal anemia can affect uterine involution, cause late postpartum hemorrhage, increase puerperal infection risk, and possibly aggravate postpartum fatigue and postpartum depression, so actively correcting puerperal anemia can obviously improve postpartum fatigue and other discomfort, reduce postpartum hemorrhage, and improve postpartum quality of life. The hypogalactia during puerperium causes the decline of pure breast feeding of newborn infants, which affects the healthy growth of newborn infants. If the stored iron is exhausted and it is difficult to supplement sufficient iron only with food, the iron supplement is required. The zinc supplement preparation for pregnant women and lactating women has positive effect on the zinc level of breast milk, and can improve the serum zinc level and the zinc content of breast milk of pregnant women, lactating women and newborn infants, and is beneficial to the growth and development of newborn infants and newborn infants. In China, partial nutrient intake of women in lactation is insufficient, and the intake of energy, VA, thiamine, riboflavin, calcium, zinc and magnesium is recommended intake respectively. The marked intake of zinc and selenium in the lactation period is 21mg and 65mg respectively, and sufficient zinc and selenium not only can ensure the intelligence development of the newborn and improve the immunity of the newborn, but also can promote the postpartum recovery of the mother and keep the mother healthy. Robinfen et al also found experimentally that copper deficiency in the mother mice positively affected the growth and development of the newborn mice, especially caused brain lesions and neurodevelopmental dysfunction, and was irreversible. Therefore, the importance of nutrition of pregnant and lactating mothers is suggested, and the influence on the growth and development of children is brought forward.
The deficiency of maternal serum VA and IgA is one of the causes of newborn diarrhea, the VA level of the maternal serum is improved, the maternal immunity is enhanced, and the newborn diarrhea can be prevented and treated. VA deficiency during pregnancy and puerperium is associated with the onset of postpartum depression. Improper diet structure of nursing mothers or infants can cause VB1 deficiency, and VB1 treatment can quickly relieve digestive, nervous or cardiovascular system symptoms of infants. The parturient lacks VB2 for a long time, skin and mucosa can be malnutrition, and VB2 has the effects of preventing and treating cracked nipple. Large dose VB6 can be used for treating acute mastitis. The pellagra disease can be generated when the nicotinic acid is deficient, the pellagra disease is manifested by dermatitis, glossitis, oropharynx, diarrhea, dysphoria, insomnia, paresthesia and the like, and the VB2 and nicotinic acid deficiency rate of the rural nursing mothers and infants in China are obviously higher than those of cities. It has been found that the erythropoietic capacity of a mammalian woman who is not supplemented with folic acid may be poor. In order to prevent folic acid from being exhausted from the dairy mother, enough nutrition of the dairy mother per day must be ensured. The folic acid is used for treating infantile diarrhea, and has no adverse reaction clinically. If VC is lacked in breast milk or artificial feeding, the scurvy of the newborn is easy to cause. The breast feeding is advocated, enough VC is supplied in the diet of pregnant women and lactating mothers, and the VC is supplemented after 3 weeks of postnatal manual feeding to prevent VC deficiency of infants. Newborns and small newborns lacking VK1 are at risk of developing severe bleeding. Proper supplementation with VK1 can prevent the occurrence of VK1 deficient bleeding. Pantothenic acid helps to form cells, maintain normal development and development of the central nervous system; has the function of producing antibodies, helps to fight infectious diseases, and helps to alleviate allergic symptoms. VE can obviously shorten the time for the puerpera to have sufficient milk, thereby accelerating the weight recovery of the newborn. In addition, the ferment has the functions of assisting proteolysis, promoting nutrition absorption and improving immunity, and is more beneficial to the physical recovery of a lying-in woman and the development and growth of a newborn.
Aiming at the physiological characteristics and nutritional requirements of the puerpera and the newborn in the lactation period, the invention adopts the gold proportion to supplement various vitamins and mineral substances required by the lactating mothers in the puerperium, is beneficial to preventing anemia, infection, depression and insomnia in the puerperium, reducing postpartum hemorrhage and improving the postpartum quality of life; meanwhile, the nutritional supplement is used for supplementing nutrition required by infants, preventing and treating neonatal diarrhea, preventing neonatal scurvy, preventing VK1 deficient hemorrhage, and maintaining the development of neonatal nervous and cardiovascular systems, and is an ideal maternal and infant nutritional health care product in puerperium.
Detailed Description
The invention relates to a lactation nutrient composition, which comprises:
the raw materials comprise calcium carbonate, ferrous fumarate, zinc gluconate, copper gluconate, retinyl acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, nicotinic acid, folic acid, L-ascorbic acid, vitamin K1, D-calcium pantothenate and D- α -tocopherol;
the auxiliary materials comprise microcrystalline cellulose, sodium starch octenylsuccinate, crospovidone, maltodextrin, magnesium stearate, sucrose, edible corn starch, acacia, tricalcium phosphate, dl- α -tocopherol, silicon dioxide, and coating premix (hydroxypropyl methyl cellulose, polyethylene glycol 6000, glycerol, talcum powder, titanium dioxide, and yellow ferric oxide).
The raw materials and auxiliary materials are processed by main processes of mixing, granulating, drying, finishing, total mixing, tabletting, coating, aluminum-aluminum packaging, external packaging and the like.
The quality requirements of raw materials and auxiliary materials are as follows:
1. calcium carbonate: the calcium carbonate injection should meet the corresponding regulations of GB 1886.214 calcium carbonate (including light calcium carbonate and heavy calcium carbonate).
2. Copper gluconate: the method meets the corresponding regulation of GB 1903.8 copper gluconate.
3. Ferrous fumarate: it should meet the corresponding regulations of ferrous fumarate in the second part of the Chinese pharmacopoeia (2015 edition).
4. Zinc gluconate: the regulation should meet the corresponding regulation of GB 8820 zinc gluconate.
5. Retinyl acetate: the vitamin C should meet the corresponding regulation of GB 14750 vitamin A.
6. Thiamine hydrochloride: it should meet the corresponding regulations of GB 14751 vitamin B1 (thiamine hydrochloride).
7. Riboflavin: the vitamin D should meet the corresponding regulations of GB 14752 vitamin B2 (riboflavin).
8. Pyridoxine hydrochloride: it should meet the corresponding regulation of GB 14753 vitamin B6 (pyridoxine hydrochloride).
9. Nicotinic acid: the corresponding regulation of GB 14757 Niacin should be met.
10. Folic acid: the corresponding regulation of GB 15570 Folic acid is met.
11. Vitamin C (L-ascorbic acid): it should meet the corresponding regulations of GB 14754 vitamin C (ascorbic acid).
Calcium D-pantothenate: it should meet the corresponding regulations of calcium pantothenate in the second part of the Chinese pharmacopoeia (2015 edition).
13. Microcrystalline cellulose: the product meets the corresponding regulation of GB 1886.103 food safety national standard food additive microcrystalline cellulose.
14. Cross-linked povidone: it should meet the corresponding regulations of the four parts of the Chinese pharmacopoeia (2015 edition) of crospovidone.
15. Sodium starch octenylsuccinate: the product is required to meet the corresponding regulation of GB 28303 food additive sodium octenyl succinate starch of national food safety standard.
16. Maltodextrin, 2: the corresponding regulation of GB/T20884 maltodextrin should be met.
17. Magnesium stearate: the magnesium stearate powder should meet the corresponding regulations of GB 1886.91 magnesium stearate.
18. Sucrose: it should conform to the corresponding regulation of sucrose in the four parts of the Chinese pharmacopoeia (2015 edition).
19. Edible corn starch: the product meets the corresponding regulation of GB/T8885 edible corn starch.
20. Gum arabic: the gum meets the corresponding regulation of GB 29949 national standard for food safety, namely acacia.
D- α -tocopherol should meet the corresponding regulations of GB 1886.233 vitamin E.
22. Tricalcium phosphate: the product is in accordance with the corresponding regulation of GB 25558 food additive tricalcium phosphate (national food safety standard).
23. Vitamin K1: it should meet the corresponding regulations of "vitamin K1" in the second part of Chinese pharmacopoeia (2015 edition).
24. Silicon dioxide: the product is in accordance with the corresponding regulation of GB 25576 national food safety standard silicon dioxide.
The medical aluminum foil meets the medical aluminum foil (YBB 00152002-2015); the polyamide/aluminum/polyvinyl chloride cold stamping solid medicinal composite hard sheet meets the requirements of polyamide/aluminum/polyvinyl chloride cold stamping solid medicinal composite hard sheet (YBB 00242002-2015).
The present invention will be described in further detail with reference to examples.
EXAMPLE 1 preparation of a lactation nutritional composition
The invention relates to a nutrient composition for lactation, which comprises the following raw and auxiliary materials:
Figure RE-GDA0002412483680000071
Figure RE-GDA0002412483680000081
wherein the coating premix is prepared by mixing hydroxypropyl methylcellulose, polyethylene glycol 6000, glycerol, talcum powder, titanium dioxide and yellow ferric oxide by a conventional method.
The preparation method of the lactation nutrient composition comprises the following steps:
1 premixing
Mixing the 50% of crospovidone with dextrin; mixing with microcrystalline cellulose by equivalent incremental method; and then uniformly mixing the powder with the premixed raw materials by an equivalent incremental method to prepare mixed powder.
2 granulating and drying
Dissolving polyvidone K30 in 60% ethanol to obtain wetting agent, adding the mixed powder, and making into soft material; granulating by using a 18-mesh screen, paving wet granules in a stainless steel plate, drying at 40 ℃ until the moisture content is 3-5% by drying in a hot air circulation manner, and thus obtaining dry granules, wherein the thickness of the wet granules cannot exceed 2 cm.
3 finishing of granules
Collecting the dry granules, and grading with 16 mesh sieve to obtain granules.
4 Total mixing
And adding the rest of crospovidone into the granules after finishing the granules, adding magnesium stearate, and performing total mixing operation to obtain a total mixed material.
5 tabletting
Loading a punch die on a tablet press, adjusting the loading amount, pressure and rotating speed by using particles, and tabletting for 1000 tablets (1.0 g/tablet), wherein the weight range of the tablets is controlled to be 0.97g +/-5 percent, so that the plain tablets are obtained. During the tabletting process, the operator checks the tablet weight every 15 minutes.
6 coating
And adding 50% ethanol into the coating premix to prepare a coating solution with the solid content of 10%. And (3) taking plain tablets, putting the plain tablets into a coating machine, starting the coating machine, preheating the plain tablets, then starting an exhaust fan and a spraying system, uniformly spraying coating liquid on the surfaces of the plain tablets, continuously blowing hot air at 40 ℃ for 5-10 minutes after the coating liquid is sprayed, then blowing cold air until the surfaces of the plain tablets reach room temperature, and taking out the coated tablets to obtain the coated tablets. The weight of the coating is increased by about 3 percent.
7 inner package
And (4) taking the inner packing material of the aluminum-aluminum package, debugging an inner packing machine, and carrying out aluminum-aluminum packaging according to 5 sheets/plate.
8 external packing
And taking the materials for external packaging such as product specifications, packaging boxes and the like, and carrying out external packaging to obtain the finished product.
9 inspection and warehousing
Sampling, checking and issuing a check report. And (4) handling warehousing procedures according to qualified inspection reports.
10 process requirements
The feeding to the inner package are all carried out in a 10 ten thousand grade clean area, and the outer package is carried out in a general production area.
EXAMPLE 2 preparation of a lactation nutritional composition
2g of oxidoreductase (SOD) and 3g of protease are adopted as the ferment, and other raw and auxiliary materials are as follows:
Figure RE-GDA0002412483680000091
Figure RE-GDA0002412483680000101
the preparation method is the same as that of example 1.
EXAMPLE 3 preparation of a lactation nutritional composition
The enzyme adopts 5g of protease, and other raw and auxiliary materials are as follows:
Figure RE-GDA0002412483680000102
Figure RE-GDA0002412483680000111
the preparation method is the same as that of example 1.
EXAMPLE 4 Final product quality testing
Two panels of the finished package prepared in examples 1-3 were randomly picked, one panel sample was inspected at all, and the other panel was sealed and stored for future reference. Wherein, the sensory requirement accords with the requirement of table 1, the physical and chemical index accords with the requirement of table 2, the microorganism index accords with the requirement of table 3, and the content measurement of the functional components accords with the requirement of table 4. The detection results of the products all meet the requirements.
TABLE 1 sensory requirements
Item Require that Detection method
Color and luster Coating is light yellow, core is light yellow or pink Visual inspection of
Taste and smell Has special taste and smell of the product, and has no peculiar smell Smelling and tasting the nose
Status of state Film-coated tablets, complete and smooth; foreign body visible without normal vision Visual inspection of
TABLE 2 physical and chemical indexes
Item Index (I) Detection method
Ash content% ≤65.0 GB5009.4
Lead (Pb), mg/kg ≤2.0 GB5009.12
Total arsenic (As), mg/kg ≤1.0 GB5009.11
Total mercury (Hg), mg/kg ≤0.3 GB5009.17
Disintegration time limit, min ≤60 Pharmacopoeia of the people's republic of China 2015 edition four parts
TABLE 3 microbiological indicators
Item Index (I) Detection method
Total number of colonies, CFU/g ≤30000 GB4789.2
Coliform group, MPN/g ≤0.92 GB4789.3MPN counting method
Mold and Yeast, CFU/g ≤50 GB4789.15
Staphylococcus aureus ≤0/25g GB4789.10
Salmonella ≤0/25g GB4789.4
TABLE 4 index of effective components
Figure RE-GDA0002412483680000121
Figure RE-GDA0002412483680000131
While embodiments of the invention have been disclosed above, it is not intended to be limited to the uses set forth in the specification and examples. It can be applied to all kinds of fields suitable for the present invention. Additional modifications will readily occur to those skilled in the art. Therefore, the invention is not to be limited to the specific details and embodiments shown and described herein, without departing from the general concept defined by the appended claims and their equivalents.

Claims (9)

1. The lactation nutrient composition is characterized by comprising the following raw materials in parts by weight:
Figure FDA0002300243270000011
2. the lactation nutrient composition according to claim 1, comprising the following raw materials in parts by weight:
Figure FDA0002300243270000012
Figure FDA0002300243270000021
3. the lactation nutrient composition according to claim 1 or 2, wherein the raw materials further comprise 0-5 parts by weight of ferment.
4. The lactation nutrient composition according to claim 3, wherein the enzyme is one or both of a protease and an oxidoreductase.
5. The lactation nutrient composition according to claim 4, wherein the composition is mixed with pharmaceutically acceptable excipients to prepare tablets, granules or capsules.
6. The lactation nutrient composition according to claim 5, wherein the lactation nutrient composition is prepared into tablets by mixing with the following auxiliary materials in parts by weight:
Figure FDA0002300243270000022
7. the lactation nutrient composition according to claim 6, wherein the lactation nutrient composition is prepared into tablets by mixing with the following auxiliary materials in parts by weight:
Figure FDA0002300243270000023
Figure FDA0002300243270000031
8. a lactation nutrient composition according to claim 6 or 7, wherein the preparation method comprises the steps of:
s1, premixing
Mixing 50% of the crospovidone in parts by weight with the dextrin in parts by weight, and mixing with the microcrystalline cellulose in parts by weight by an equivalent incremental method; then uniformly mixing the raw materials with the parts by weight by an equivalent incremental method to prepare mixed powder;
s2, granulating and drying
The povidone K30 in parts by weight is dissolved in 60% ethanol to be used as a wetting agent, and the mixed powder is added for wetting to prepare a soft material; granulating by using a 18-mesh screen, flatly paving wet granules in a stainless steel plate, wherein the thickness of the wet granules cannot exceed 2 cm, drying by hot air circulation at the temperature of 40 ℃ until the moisture is 3-5%, and preparing dry granules;
s3, straightening granules
Collecting the dry granules, and grading the granules through a 16-mesh sieve to prepare granules after grading;
s4 Total mixing
Adding the rest of crospovidone into the granules after finishing granules, adding the magnesium stearate in the parts by weight, and performing total mixing operation to obtain a total mixed material;
s5, tabletting
Loading a punch die on a tablet press, adjusting the loading amount, pressure and rotating speed by using particles, and tabletting to obtain plain tablets, wherein the weight range of the tablets is controlled to be 0.97g +/-5%;
s6 coating
Taking the coating premix, and adding 50% ethanol to prepare a coating solution with the solid content of 10%; and (3) taking the plain tablets, putting the plain tablets into a coating machine, preheating the plain tablets, uniformly spraying a coating solution on the surfaces of the plain tablets, continuously blowing hot air at 40 ℃ for 5-10 minutes after the coating solution is sprayed, blowing cold air to the surfaces of the plain tablets to reach room temperature, taking out the coated tablets, and obtaining the coated tablets, wherein the coating weight is increased by 2.85-3.15%.
9. Use of a lactation nutrient composition according to any one of claims 1-7 as a nutritional substance for a lactating woman.
CN201911218862.0A 2019-12-03 2019-12-03 Nutrient composition for lactation period and preparation method and application thereof Pending CN111053242A (en)

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CN201911218862.0A CN111053242A (en) 2019-12-03 2019-12-03 Nutrient composition for lactation period and preparation method and application thereof

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104856030A (en) * 2015-05-28 2015-08-26 南阳市汇博生物技术有限公司 Full-nutritional milk formula food for lying-in women and preparation method for food
CN107455758A (en) * 2017-08-11 2017-12-12 步源堂生物科技有限公司 A kind of pregnant woman supplements the health products of multivitamin and mineral matter

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104856030A (en) * 2015-05-28 2015-08-26 南阳市汇博生物技术有限公司 Full-nutritional milk formula food for lying-in women and preparation method for food
CN107455758A (en) * 2017-08-11 2017-12-12 步源堂生物科技有限公司 A kind of pregnant woman supplements the health products of multivitamin and mineral matter

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Application publication date: 20200424