CN110742269B - Memory enhancing composition suitable for postpartum women and preparation method thereof - Google Patents

Memory enhancing composition suitable for postpartum women and preparation method thereof Download PDF

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Publication number
CN110742269B
CN110742269B CN201911259857.4A CN201911259857A CN110742269B CN 110742269 B CN110742269 B CN 110742269B CN 201911259857 A CN201911259857 A CN 201911259857A CN 110742269 B CN110742269 B CN 110742269B
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parts
powder
composition
chinese herbal
herbal medicine
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CN110742269A (en
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姜海燕
陈明霞
罗丽莲
肖艳皎
韩雅慧
易斌
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Beijing Silian Pharmaceutical Industry Co ltd
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Beijing Silian Pharmaceutical Industry Co ltd
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract

The invention discloses a memory-enhancing composition suitable for postpartum women and a preparation method thereof, belonging to the technical field of memory-enhancing compositions, the composition comprises 0.001-0.024 part of folic acid, 25-120 parts of Chinese herbal medicine powder, 10-50 parts of food materials and 1-4 parts of milk mineral salt, and the Chinese herbal medicine powder and the food material powder are firstly prepared; then putting the Chinese herbal medicine powder, the food material powder, the milk mineral salt and the folic acid into a stirrer, and uniformly mixing to obtain composition powder; then the powder of the composition is molded to obtain the composition with a certain dosage form; finally, the formed composition is subjected to quality inspection and packaging. The composition disclosed by the invention can obviously improve the physical and psychological conditions of the puerpera, promote qi and blood circulation of the puerpera, provide nutritional requirements for the puerpera, further improve the concentration and memory of the puerpera, and has no toxic or side effect.

Description

Memory enhancing composition suitable for postpartum women and preparation method thereof
Technical Field
The invention belongs to the technical field of memory enhancing compositions, and particularly relates to a memory enhancing composition suitable for postpartum women and a preparation method thereof.
Background
Along with the improvement of living standard of people, the consciousness of preventing and treating diseases of people is gradually strengthened, pregnant and lying-in women are a special group, and the postpartum recovery condition of the pregnant and lying-in women is related to the health of the lying-in women and infants. The phenomenon of serious decline of attention and memory after delivery of women is easy to occur due to high mental stress during delivery and pain during delivery. After a woman experiences a 40-week pregnancy period, a new life is born, within 24 hours after delivery, the hormone level in the body of the parturient is rapidly changed, and the mental state of the parturient is influenced by antenatal mental state fluctuation, tension and fear in the production, pain caused by operation, family mental disease genetic history and the like, so that postpartum depression is caused. Mild postpartum depression is manifested by depressed mood, hypomnesis, drowsiness, depression and depression, anxiety to newborn health, decreased appetite, insomnia, etc., and at this time, the people can recover quickly by careing for cares; severe postpartum depression is difficult to cure through self-regulation, patients often show hallucinations, even have the idea of suicide or injury to newborns, and the patients need to gradually recover health by means of physical treatment methods or drug treatment for the severe postpartum depression. Whether a puerpera suffering from postpartum depression or a healthy puerpera suffers from postpartum depression, due to the change of physical conditions and the transfer of attention during nursing of a newborn, memory decline to a certain degree inevitably occurs, certain troubles are brought to the life of the puerpera, and active treatment is needed.
The Chinese patent application CN103445165A (a product and a composition thereof for improving sub-health state) adopts maca and oyster to prepare the composition, can regulate hormone secretion, improve sleep quality and enhance memory, has obvious curative effect on female climacteric syndrome and prenatal or postpartum weakness, and can also be added with tartary buckwheat to achieve a certain anticancer effect; the existence of the oysters can better improve the effect of the maca, so that the maca can better play a role, and the sub-health state of a human body can be rapidly improved. Chinese patent application CN108653684A (a Chinese medicinal composition and a preparation method and application thereof) uses Chinese angelica, szechuan lovage rhizome, platycodon root, turmeric root-tuber, cinnabar, indian buead, malt and the like to grind and decoct to obtain liquid medicine which can be used for nourishing blood and soothing nerves, tonifying brain, calming, inducing resuscitation and restoring consciousness and enhancing memory, and can treat various mental diseases by synergistic coordination and enhancement among the raw materials. The Chinese invention patent CN105963359A (application of general hemp extract in preparing medicament for treating depression) mixes industrial hemp fructus Cannabis extract and industrial hemp fructus Cannabis extract according to a proper proportion to prepare the medicament, the medicament has obvious relieving effect on the secondary decline of learning and memory of depression, and the depression mainly comprises endogenous depression, reactive depression, latent depression, medicament-induced secondary depression, climacteric or postpartum depression and the like.
The products or medicines prepared by the three patent applications have the function of enhancing the memory, but are not products specially developed for memory reduction caused by female postpartum depression. The female is weak after delivery, and because the medicine contains components for inhibiting the production of breast milk, the puerpera can reduce lactation after taking the medicine, and the medicine enters the body of the infant along with the breast milk, thus being harmful to the body health of the infant; in addition, the postpartum body of the female is weak, uterus, bone joints, ligaments and the like are changed to a certain extent, the immunity of the postpartum body of the female is reduced, the female is susceptible to diseases, and the female needs to be maintained better to recover to the pre-pregnancy state. If the medicine is taken for treatment, the memory of the lying-in women is enhanced, and meanwhile, a plurality of side effects are brought.
Disclosure of Invention
The invention aims to solve the technical problem that no product for enhancing memory is specially used for postpartum women in the prior art.
In order to solve the technical problems, the invention discloses a composition for enhancing memory for postpartum women, which comprises folic acid and Chinese herbal medicine powder, and the content of each component is as follows by mass: 0.001-0.024 parts of folic acid and 25-120 parts of Chinese herbal medicine powder; furthermore, 0.005-0.015 part of folic acid and 70-100 parts of Chinese herbal medicine powder;
folic acid is a water-soluble B-group vitamin necessary for human bodies, when the human bodies convert and utilize sugar and amino acid, the folic acid is required to participate in reaction, the folic acid is an essential substance for cell proliferation of the human bodies, the demand of pregnant and lying-in women on the folic acid is several times of that of normal people, women are weak after production, particularly the lying-in women needing to be suckled have loss of a large amount of nutrients every day, and the folic acid is supplemented to promote the growth of red blood cells, improve the hematopoietic capacity in the bodies, promote metabolism and enable the bodies to recover quickly. Research shows that the concentration of homocysteine in blood plasma is increased to cause mental diseases, such as senile dementia, depression and the like, the metabolic process of human homocysteine needs the assistance of folic acid, and the folic acid participates in reaction to convert homocysteine into methionine, and then is discharged out of the body to help patients to recover early; and researchers think that folic acid can enhance adult memory, so that postpartum women can supplement folic acid, the risk of postpartum depression can be reduced, and memory can be improved.
The Chinese herbal medicine powder is obtained by extracting Chinese herbal medicines, wherein the Chinese herbal medicines comprise the following components in parts by mass: 2-12 parts of glossy privet fruit, 3-15 parts of black sesame, 3-30 parts of codonopsis pilosula, 3-15 parts of longan aril, 3.5-15 parts of spina date seed, 3-27 parts of acanthopanax, 2-10 parts of eucommia bark, 4-15 parts of poria cocos, 1-12 parts of dandelion, 1-14 parts of red date powder, 0.5-10 parts of pangolin, 1-5 parts of ricepaperplant pith, 3-30 parts of motherwort, 1-9 parts of donkey-hide gelatin and 1-12 parts of loofah sponge. The traditional Chinese medicine components such as glossy privet fruit, black sesame, codonopsis pilosula and the like are supplemented for postpartum women who consume a large amount of energy in pregnancy and production process, so that the traditional Chinese medicine components can nourish yin, tonify qi, treat lying-in women with dizziness, waist and knee soreness and the like, improve the physical quality of the lying-in women and promote the lying-in women to recover as soon as possible; meanwhile, dandelion, ricepaperplant pith, loofah sponge and the like can promote lactation of puerperae, dredge meridian passage and solve the problem of less postpartum milk.
The composition also comprises 10-50 parts by mass of food materials; the food material comprises the following components in parts by mass: 2-10 parts of solid rice wine, 3-20 parts of glutinous rice flour, 1-16 parts of crucian powder, 2-10 parts of shrimp meal, 3-25 parts of fruit and vegetable powder, 2-20 parts of beef powder and 1-23 parts of chicken powder. The traditional Chinese medicine always stresses the importance of food therapy, particularly for postpartum women, a large amount of nutrition needs to be supplemented to promote the body to recover as soon as possible, and crucian powder, shrimp powder, beef powder, chicken powder and the like are high-protein and high-calcium foods, so that the loss of protein and calcium of puerperae can be supplemented, the skin of the woman can be promoted to recover elasticity as soon as possible, and the aging is delayed; the solid rice wine is prepared by performing special drying technology on rice wine lees in liquid rice wine, usually performing vacuum freeze drying to obtain block-shaped solid, which is convenient for transportation and storage, and the rice wine and glutinous rice flour can be used for warming and tonifying body, tonifying middle-jiao and Qi, strengthening spleen and stomach, stopping sweating, and promoting the rapid recovery of puerpera; the fruit and vegetable powder is a powdery food material prepared by freeze drying fresh fruits and vegetables, provides a great amount of plant nutrient substances such as cellulose, vegetable protein, vitamins and the like for lying-in women, and can enrich blood, beautify face and resist aging.
The composition also comprises 1-4 parts of milk mineral salt, wherein the milk mineral salt is an artificially synthesized nutrient substance, is prepared by removing protein, lactose and other components from whey, is rich in various minerals, particularly calcium and phosphorus, can supplement the minerals lost in the body of a puerpera, improve the bone density and bone toughness of the puerpera, has an effect obviously superior to that of directly supplementing inorganic minerals, and can be continuously maintained.
Further, the Chinese herbal medicine comprises the following components in parts by mass: 5-10 parts of glossy privet fruit, 4-9 parts of black sesame, 5-13 parts of codonopsis pilosula, 6-10 parts of arillus longan, 6-13 parts of spina date seed, 7-15 parts of acanthopanax root, 4-8 parts of eucommia ulmoides, 6-11 parts of poria cocos, 3-9 parts of dandelion, 4-9 parts of red date powder, 3-9 parts of pangolin scales, 2-5 parts of ricepaper pith, 4-8 parts of leonurus, 2-8 parts of donkey-hide gelatin and 5-12 parts of loofah sponge.
Further, the Chinese herbal medicine also comprises the following components in parts by mass: 3-15 parts of prepared rehmannia root, 1-6 parts of rhodiola rosea, 1-10 parts of fructus alpiniae oxyphyllae, 1-10 parts of polygala tenuifolia, 1-6 parts of polygonum multiflorum, 3-15 parts of gordon euryale seed, 2-12 parts of lucid ganoderma, 2-12 parts of wolfberry fruit, 3-30 parts of astragalus mongholicus and 1-10 parts of rhizoma acori graminei. The Chinese herbal medicines are also good nourishing products and are very suitable for women to eat after childbirth.
Further, the food material comprises the following components in parts by mass: 3-5 parts of solid rice wine, 10-15 parts of glutinous rice flour, 2-15 parts of crucian powder, 7-9 parts of shrimp meal, 5-25 parts of fruit and vegetable powder, 3-18 parts of beef powder and 3-20 parts of chicken powder.
Furthermore, the composition according to any one of the above technical schemes can be used for preparing foods, health products or medicines for enhancing memory suitable for postpartum women.
The invention also claims a preparation method of the composition, which comprises the following steps:
(1) Decocting the Chinese medicinal materials in water, filtering, concentrating, and drying to obtain Chinese medicinal powder;
(2) Grinding each component in the food material into granules, and uniformly mixing the granules according to the proportion to obtain food material powder;
(3) Mixing the Chinese herbal medicine powder, the food material powder, the milk mineral salt and the folic acid uniformly to obtain composition powder;
(4) Preparing the composition powder into a composition with a certain dosage form according to certain dosage form requirements;
(5) And (4) performing quality inspection on the molded composition and packaging.
Further, before the Chinese herbal medicines are decocted in the step (1), the Chinese herbal medicines are soaked in water for 5-30 minutes, and further, the soaking time is 30 minutes.
Further, the relative density of the filtrate after concentration in the step (1) is 1.10-1.25g/cm 3 。
Furthermore, auxiliary materials are added in the step (3).
Furthermore, the auxiliary materials comprise one or more of a disintegrating agent, a lubricating agent, an adhesive, a diluent, a coloring agent, an absorbent, a bacteriostatic agent and an antioxidant.
Further, the dosage form of the composition prepared in the step (4) comprises one or more of tablets, capsules, granules and dripping pills, wherein the capsules can also be soft capsules.
Compared with the prior art, the composition for enhancing memory suitable for postpartum women and the preparation method thereof have the following advantages:
1. the composition contains folic acid, and can improve metabolism of puerperae, relieve postpartum depression and improve memory.
2. The composition disclosed by the invention is matched with the traditional Chinese medicine composition, so that the body of a puerpera can be conditioned, qi and kidney are tonified, the body immunity of the puerpera is improved, the psychological state of the puerpera is improved, and the physical condition of the puerpera is fundamentally improved.
3. The traditional Chinese medicine composition adopted by the invention can supplement trace elements required by a human body, promote metabolism of the human body and provide important supply for the physical health of a lying-in woman.
4. The food material rich in nutrient substances is also added into the composition, so that the nutrition supply is provided for the lying-in woman, and the body of the lying-in woman is promoted to be recovered as soon as possible.
5. The composition provided by the invention aims at the characteristic that the woman can not take medicines in a special postpartum period, adopts the traditional Chinese medicine concept, and combines the traditional Chinese medicines with the food therapy, so that the body of the puerpera can be recovered, and the memory of the puerpera can be enhanced.
6. The composition also has the effects of promoting lactation of the puerpera, improving skin conditions of the puerpera and resisting aging.
7. The composition has the advantages of rich raw material sources, no toxic or side effect, long-term taking, improvement of the constitution of the lying-in woman through the synergistic effect of various raw materials, lasting effect and difficult rebound.
8. The composition of the invention has simple preparation method and is easy to realize mass production.
Detailed Description
The technical solution of the present invention will be described in detail by the following specific examples.
Firstly, chinese herbal medicine powder and food material powder are prepared to be used as intermediate materials for standby.
Changing the formula of the Chinese herbal medicines, and selecting different types and contents of the Chinese herbal medicines; or changing the preparation process to prepare 4 different Chinese herbal medicine powders, which are respectively marked as the Chinese herbal medicine powders L1, L2, L3 and L4.
1. Preparation of Chinese herbal medicine powder
1. Preparation of Chinese herbal medicine powder L1
(1) Weighing 6 parts of glossy privet fruit, 6 parts of black sesame, 9 parts of codonopsis pilosula, 9 parts of arillus longan, 10 parts of spina date seed, 9 parts of acanthopanax, 6 parts of eucommia bark, 10 parts of poria cocos, 7 parts of dandelion, 6 parts of red date powder, 4 parts of pangolin scales, 4 parts of ricepaperplant pith, 6 parts of motherwort, 3 parts of donkey-hide gelatin, 10 parts of loofah sponge, 9 parts of prepared rehmannia root, 3 parts of rhodiola rosea, 3 parts of fructus alpiniae oxyphyllae, 3 parts of polygala tenuifolia, 3 parts of polygonum multiflorum, 9 parts of gorgon fruit, 6 parts of lucid ganoderma, 6 parts of wolfberry fruit, 9 parts of astragalus mongholicus and 3 parts of rhizoma acori graminei. Firstly, cleaning the Chinese herbal medicine raw materials to remove impurities, then adding the Chinese herbal medicine raw materials into water to soak for 30 minutes, and adding water to ensure that the water surface is 2cm higher than the Chinese herbal medicine;
(2) After soaking, decocting in a casserole: boiling water with strong fire, maintaining with slow fire for about 30min, and filtering to obtain primary filtrate; adding water to the Chinese herbal medicine raw materials, decocting for the second time by the same method, and filtering to obtain a second filtrate after the decoction is finished; adding water, decocting for the third time, and filtering to obtain the third filtrate;
(3) Mixing the above three filtrates, heating to 70 deg.C, concentrating under reduced pressure until the relative density of the filtrate is 1.20g/cm 3 Stopping heating, and drying the concentrated filtrate to obtain block-shaped Chinese medicinal granuleAnd (3) uniformity of the product, grinding the granules to obtain Chinese herbal medicine powder L1 for later use.
2. Preparation of Chinese herbal medicine powder L2
(1) Weighing 6 parts of glossy privet fruit, 6 parts of black sesame, 9 parts of codonopsis pilosula, 9 parts of longan aril, 10 parts of spina date seed, 9 parts of acanthopanax, 6 parts of eucommia bark, 10 parts of poria cocos, 7 parts of dandelion, 6 parts of red date powder, 4 parts of pangolin scales, 4 parts of ricepaperplant pith, 6 parts of motherwort, 3 parts of donkey-hide gelatin and 10 parts of loofah sponge. Firstly, cleaning the Chinese herbal medicine raw materials to remove impurities, then adding the Chinese herbal medicine raw materials into water to soak for 30 minutes, and adding water to ensure that the water surface is 2cm higher than the Chinese herbal medicine;
(2) After soaking, decocting in a casserole: boiling water with strong fire, maintaining with slow fire for about 30min, and filtering to obtain primary filtrate; adding water to the Chinese herbal medicine raw materials, decocting for the second time by the same method, and filtering to obtain a second filtrate after the decoction is finished; adding water, decocting for the third time, and filtering to obtain the third filtrate;
(3) Mixing the above three filtrates, heating to 70 deg.C, concentrating under reduced pressure until the relative density of the filtrate is 1.20g/cm 3 And (3) stopping heating, drying the concentrated filtrate to obtain blocky Chinese herbal medicine particles, and grinding the particles to obtain Chinese herbal medicine powder L2 for later use in order to ensure the uniformity of the final product.
3. Preparation of Chinese herbal medicine powder L3
(1) Weighing 2 parts of glossy privet fruit, 3 parts of black sesame, 3 parts of codonopsis pilosula, 4 parts of longan aril, 4 parts of spina date seed, 25 parts of acanthopanax, 10 parts of eucommia bark, 15 parts of poria cocos, 1 part of dandelion, 14 parts of red date powder, 1 part of pangolin, 1 part of ricepaperplant pith, 20 parts of motherwort, 1 part of donkey-hide gelatin and 1 part of loofah sponge by mass. Firstly, cleaning the Chinese herbal medicine raw materials to remove impurities, then adding the Chinese herbal medicine raw materials into water to soak for 30 minutes, and adding water to ensure that the water surface is 2cm higher than the Chinese herbal medicine;
(2) After soaking, decocting in a casserole: boiling water with strong fire, maintaining with slow fire for about 30min, and filtering to obtain primary filtrate; adding water to the Chinese herbal medicine raw materials, decocting for the second time by the same method, and filtering to obtain a second filtrate after the decoction is finished; adding water, decocting for the third time, and filtering to obtain the third filtrate;
(3) Mixing the above three filtrates, heating to 70 deg.C, concentrating under reduced pressure until the relative density of the filtrate is 1.20g/cm 3 And (3) stopping heating, drying the concentrated filtrate to obtain blocky Chinese herbal medicine particles, and grinding the particles to obtain Chinese herbal medicine powder L3 for later use in order to ensure the uniformity of the final product.
4. Preparation of Chinese herbal medicine powder L4
(1) Weighing 6 parts of glossy privet fruit, 6 parts of black sesame, 9 parts of codonopsis pilosula, 9 parts of arillus longan, 10 parts of spina date seed, 9 parts of acanthopanax, 6 parts of eucommia bark, 10 parts of poria cocos, 7 parts of dandelion, 6 parts of red date powder, 4 parts of pangolin scales, 4 parts of ricepaperplant pith, 6 parts of motherwort, 3 parts of donkey-hide gelatin, 10 parts of loofah sponge, 9 parts of prepared rehmannia root, 3 parts of rhodiola rosea, 3 parts of fructus alpiniae oxyphyllae, 3 parts of polygala tenuifolia, 3 parts of polygonum multiflorum, 9 parts of gorgon fruit, 6 parts of lucid ganoderma, 6 parts of wolfberry fruit, 9 parts of astragalus mongholicus and 3 parts of rhizoma acori graminei. Firstly, cleaning the Chinese herbal medicine raw materials to remove impurities, then adding the Chinese herbal medicine raw materials into water to soak for 2 minutes, and adding water to ensure that the water surface is 2cm higher than the Chinese herbal medicine;
(2) After soaking, decocting in a casserole: boiling water with strong fire, maintaining with slow fire for about 30min, and filtering to obtain primary filtrate; adding water to the Chinese herbal medicine raw materials, decocting for the second time by the same method, and filtering to obtain a second filtrate after the decoction is finished; adding water, decocting for the third time, and filtering to obtain the third filtrate;
(3) Mixing the above three filtrates, heating to 70 deg.C, concentrating under reduced pressure until the relative density of the filtrate is 1.20g/cm 3 And (3) stopping heating, drying the concentrated filtrate to obtain blocky Chinese herbal medicine particles, and grinding the particles to obtain Chinese herbal medicine powder L4 for later use in order to ensure the uniformity of a final product.
The raw materials and some process parameters for preparing the Chinese herbal medicine powder are shown in the following table 1.
Table 1 raw materials and amounts of herbal powders L1-L4 and some process parameters
Figure BDA0002311320950000061
Figure BDA0002311320950000071
2. Preparation of food material powder
1. Preparation of food material powder P1
Weighing 4 parts of solid rice wine, 11 parts of glutinous rice flour, 3 parts of crucian carp meal, 9 parts of shrimp meal, 6 parts of fruit and vegetable powder, 9 parts of beef meal and 3 parts of chicken meal in parts by mass, putting the mixture into a stirrer, uniformly mixing, and grinding to obtain food material powder P1 for later use.
2. Preparation of food material powder P2
Weighing 8 parts of solid rice wine, 3 parts of glutinous rice flour, 2 parts of crucian carp meal, 3 parts of shrimp meal, 5 parts of fruit and vegetable powder, 2 parts of beef powder and 1 part of chicken powder in parts by mass, putting the materials into a stirrer, uniformly mixing, and grinding to obtain food material powder P2 for later use.
The raw materials and the amounts used for preparing the food material powder as described above are shown in table 2 below.
TABLE 2 raw materials and amounts of food material powders P1-P2
Figure BDA0002311320950000072
3. Preparing composition by using the obtained Chinese herbal medicine powder and food material powder
Example 1
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L1 and 20 parts of food material powder P1, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Auxiliary materials are selected, the mass of the auxiliary materials accounts for 29 percent of the powder of the composition, and the auxiliary materials specifically comprise 23.5 percent of microcrystalline cellulose, 5 percent of sodium carboxymethyl starch and 0.5 percent of magnesium stearate. Adding the composition powder, microcrystalline cellulose and sodium carboxymethyl starch into a stirrer, uniformly mixing to obtain composition powder, granulating the composition powder with 60% ethanol, drying, grading, adding magnesium stearate, and totally mixing to obtain the total mixed granule of the composition.
Adding the total mixed granules of the composition into a full-automatic capsule filling machine, using 0# standard hydroxypropyl methyl cellulose (HPMC) vegetal capsules, filling 0.4g of the total mixed granules of the composition into each capsule, performing full-automatic filling, and removing fine powder adsorbed on the outer wall of the capsule on a capsule polishing machine after the filling is finished so as to ensure that the surface of the capsule is smooth and bright.
3. Quality inspection and packaging
And (5) performing quality inspection on the capsules, and packaging to obtain a composition product, which is marked as S1.
Example 2
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.001 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L1 and 20 parts of food material powder P1, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
And (2) selecting auxiliary materials, wherein the auxiliary materials account for 30.5% of the composition powder in mass, specifically comprise 26.5% of lactose, 30% of PVP-K and 1% of magnesium stearate, adding the composition powder, the lactose and the PVP-K30 into a stirrer, uniformly mixing to obtain composition powder, granulating the composition powder by using 60% of ethanol, drying, finishing granules, adding the magnesium stearate, and totally mixing to obtain the total mixed granules of the composition.
And adding the total mixed particles of the composition into a tablet machine, and forming to obtain tablets, wherein the mass of the total mixed particles of the composition in each tablet is 0.4g.
3. Quality inspection and packaging
And (5) carrying out quality inspection on the tablets, and packaging to obtain a composition product, which is marked as S2.
Example 3
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L1 and 20 parts of food material powder P2 by mass, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Adding the composition powder and an auxiliary material (the mass of the auxiliary material is 29 percent of the composition powder) into a stirrer, and uniformly mixing to obtain the composition powder, wherein the auxiliary material comprises 5 percent of dextrin, 21 percent of lactose and 30 percent of PVP-K.
Adding the medicinal powder into a granulator, granulating with 60% ethanol, drying, and grading to obtain granule.
3. Quality inspection and packaging
And (5) performing quality inspection and packaging on the granules to obtain a composition product, and recording as S3.
Example 4
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L2 and 20 parts of food material powder P2, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Adding the composition powder and an auxiliary material (the mass of the auxiliary material is 70% of the composition powder) into a stirrer, and uniformly mixing to obtain the composition powder, wherein the auxiliary material comprises polyethylene glycol 4000.
Melting polyethylene glycol 4000, adding the composition powder, mixing, and adding into a full-automatic dripping pill machine, and preparing into dripping pill by conventional method, wherein each dripping pill contains 0.2g of the composition powder.
3. Quality inspection and packaging
And (5) performing quality inspection on the dripping pills, and packaging to obtain a composition product, which is marked as S4.
Example 5
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L3 and 20 parts of food material powder P2 by mass, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Auxiliary materials are selected, wherein the mass of the auxiliary materials accounts for 29 percent of the powder of the composition, and the auxiliary materials specifically comprise 23.5 percent of microcrystalline cellulose, 5 percent of sodium carboxymethyl starch and 0.5 percent of magnesium stearate. Adding the composition powder, microcrystalline cellulose and sodium carboxymethyl starch into a stirrer, uniformly mixing to obtain composition powder, granulating with 60% ethanol, drying, grading, adding magnesium stearate, and mixing to obtain composition granule.
Adding the total mixed granules of the composition into a full-automatic capsule filling machine, using 0# standard hydroxypropyl methyl cellulose (HPMC) vegetal capsules, filling 0.4g of the total mixed granules of the composition into each capsule, performing full-automatic filling, and removing fine powder adsorbed on the outer wall of the capsule on a capsule polishing machine after the filling is finished so as to ensure that the surface of the capsule is smooth and bright.
3. Quality inspection and packaging
And (5) performing quality inspection on the capsules, and packaging to obtain a composition product, which is marked as S5.
Example 6
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L4 and 20 parts of food material powder P2, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Selecting auxiliary materials, wherein the auxiliary materials account for 67% of the composition powder in mass and specifically comprise 63% of lactose, 30% of PVP-K and 1% of magnesium stearate, adding the composition powder, the lactose and the PVP-K30 into a stirrer, uniformly mixing to obtain composition powder, granulating the composition powder with 60% of ethanol, drying, finishing granules, adding the magnesium stearate, and performing total mixing to obtain the composition total mixed granules.
And adding the total mixed particles of the composition into a tablet machine, and forming to obtain tablets, wherein the mass of the total mixed particles of the composition in each tablet is 0.4g.
3. Quality inspection and packaging
And (5) carrying out quality inspection on the tablets, and packaging to obtain a composition product, which is marked as S6.
Example 7
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L2 and 20 parts of food material powder P1, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Selecting auxiliary materials, wherein the auxiliary materials account for 67% of the composition powder in mass and specifically comprise 63% of lactose, 30% of PVP-K and 1% of magnesium stearate, adding the composition powder, the lactose and the PVP-K30 into a stirrer, uniformly mixing to obtain composition powder, granulating the composition powder with 60% of ethanol, drying, finishing granules, adding the magnesium stearate, and performing total mixing to obtain the composition total mixed granules.
And adding the total mixed particles of the composition into a tablet machine, and forming to obtain tablets, wherein the mass of the total mixed particles of the composition in each tablet is 0.4g.
3. Quality inspection and packaging
And (5) carrying out quality inspection on the tablets, and packaging to obtain a composition product, which is marked as S7.
Example 8
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L3 and 20 parts of food material powder P1 by mass, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Auxiliary materials are selected, wherein the mass of the auxiliary materials accounts for 29 percent of the powder of the composition, and the auxiliary materials specifically comprise 23.5 percent of microcrystalline cellulose, 5 percent of sodium carboxymethyl starch and 0.5 percent of magnesium stearate. Adding the composition powder, microcrystalline cellulose and sodium carboxymethyl starch into a stirrer, uniformly mixing to obtain composition powder, granulating with 60% ethanol, drying, grading, adding magnesium stearate, and mixing to obtain composition granule.
Adding the total mixed granules of the composition into a full-automatic capsule filling machine, using 0# standard hydroxypropyl methyl cellulose (HPMC) vegetal capsules, filling 0.4g of the total mixed granules of the composition into each capsule, performing full-automatic filling, and removing fine powder adsorbed on the outer wall of the capsule on a capsule polishing machine after the filling is finished so as to ensure that the surface of the capsule is smooth and bright.
3. Quality inspection and packaging
And (5) performing quality inspection on the capsules, and packaging to obtain a composition product, which is marked as S8.
Example 9
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.012 part of folic acid by mass, adding 80 parts of the prepared Chinese herbal medicine powder L4 and 20 parts of food material powder P1 by mass, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Adding the composition powder and an auxiliary material (the mass of the auxiliary material is 29 percent of the composition powder) into a stirrer, and uniformly mixing to obtain the composition powder, wherein the auxiliary material comprises 5 percent of dextrin, 21 percent of lactose and 30 percent of PVP-K.
Adding the medicinal powder into a granulator, granulating with 60% ethanol, drying, and grading to obtain granule.
3. Quality inspection and packaging
And (5) performing quality inspection on the granules, and packaging to obtain a composition product, which is marked as S9.
Example 10
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.024 part of folic acid by mass, adding 120 parts of the prepared Chinese herbal medicine powder L1 and 50 parts of food material powder P1, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Adding the composition powder and an auxiliary material (the mass of the auxiliary material is 72 percent of the composition powder) into a stirrer, and uniformly mixing to obtain the composition powder, wherein the auxiliary material comprises polyethylene glycol 4000.
Melting polyethylene glycol 4000, adding the composition powder, mixing, and adding into a full-automatic dripping pill machine, and preparing into dripping pill by conventional method, wherein each dripping pill contains 0.2g of the composition powder.
3. Quality inspection and packaging
And (5) carrying out quality inspection on the dripping pills, and packaging to obtain a composition product, which is marked as S10.
Example 11
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.015 part of folic acid by mass, adding 70 parts of the prepared Chinese herbal medicine powder L1 and 50 parts of food material powder P1, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Selecting auxiliary materials, wherein the mass of the auxiliary materials is 67% of that of the composition powder, and specifically comprises 63% of lactose, 30% of PVP-K and 1% of magnesium stearate, adding the composition powder, the lactose and the PVP-K30 into a stirrer to be uniformly mixed to obtain composition powder, granulating, drying and granulating the composition powder by using 60% ethanol, adding the magnesium stearate, and performing total mixing to obtain the composition total mixed granules.
And adding the total mixed particles of the composition into a tablet machine, and forming to obtain tablets, wherein the mass of the total mixed particles of the composition in each tablet is 0.4g.
3. Quality inspection and packaging
And (5) carrying out quality inspection on the tablets, and packaging to obtain a composition product, which is marked as S11.
Example 12
1. Preparation of powder composition
Weighing 3 parts of milk mineral salt and 0.005 part of folic acid by mass, adding 25 parts of the prepared Chinese herbal medicine powder L1 and 10 parts of food material powder P1, mixing, putting into a stirrer, and stirring uniformly to obtain the composition powder.
2. Shaping of
Adding the composition powder and adjuvants (70% of the composition powder in the mass) into a stirrer, and mixing uniformly to obtain composition powder, wherein the adjuvants comprise dextrin 5%, lactose 62%, and PVPK 3%.
Adding the medicinal powder into a granulator, granulating with 60% ethanol, drying, and grading to obtain granule.
3. Quality inspection and packaging
And (5) performing quality inspection on the granules, and packaging to obtain a composition product, which is marked as S12.
Comparative example 1
1. Preparation of powder composition
Weighing 6 parts of milk mineral salt and 0.0012 part of folic acid by mass, adding the prepared 25 parts of Chinese herbal medicine powder L1, mixing, putting into a stirrer, and uniformly stirring to obtain the composition powder.
2. Shaping of
Auxiliary materials are selected, the mass of the auxiliary materials accounts for 29 percent of the powder of the composition, and the auxiliary materials specifically comprise 23.5 percent of microcrystalline cellulose, 5 percent of sodium carboxymethyl starch and 0.5 percent of magnesium stearate. Adding the composition powder, microcrystalline cellulose and sodium carboxymethyl starch into a stirrer, uniformly mixing to obtain composition powder, granulating the composition powder with 60% ethanol, drying, grading, adding magnesium stearate, and totally mixing to obtain the total mixed granule of the composition.
Adding the total mixed granules of the composition into a full-automatic capsule filling machine, using 0# standard hydroxypropyl methyl cellulose (HPMC) vegetal capsules, filling 0.4g of the total mixed granules of the composition into each capsule, performing full-automatic filling, and removing fine powder adsorbed on the outer wall of the capsule on a capsule polishing machine after the filling is finished so as to ensure that the surface of the capsule is smooth and bright.
And then, carrying out quality inspection on the capsules and packaging to obtain a composition product, which is marked as B1.
Comparative example 2
Taking 80 parts of Chinese herbal medicine powder L1 and 20 parts of food material powder P1, adding folic acid and milk mineral salt, and adding into a stirrer to mix uniformly to obtain composition powder.
Auxiliary materials are selected, the mass of the auxiliary materials accounts for 29 percent of the powder of the composition, and the auxiliary materials specifically comprise 23.5 percent of microcrystalline cellulose, 5 percent of sodium carboxymethyl starch and 0.5 percent of magnesium stearate. Adding the composition powder, microcrystalline cellulose and sodium carboxymethyl starch into a stirrer, uniformly mixing to obtain composition powder, granulating the composition powder with 60% ethanol, drying, grading, adding magnesium stearate, and totally mixing to obtain the total mixed granule of the composition.
Adding the total mixed granules of the composition into a full-automatic capsule filling machine, using 0# standard hydroxypropyl methyl cellulose (HPMC) vegetal capsules, filling 0.4g of the total mixed granules of the composition into each capsule, performing full-automatic filling, and removing fine powder adsorbed on the outer wall of the capsule on a capsule polishing machine after the filling is finished so as to ensure that the surface of the capsule is smooth and bright.
And then, performing quality inspection on the capsules, and packaging to obtain a composition product, which is marked as B2.
Comparative example 3
The method for preparing the Chinese herbal medicine powder L1 by adopting the invention is used for preparing the Chinese herbal medicine powder L5, the difference is only that the Chinese herbal medicine raw materials are different, and the raw materials for preparing the Chinese herbal medicine powder L5 are as follows: the traditional Chinese medicine composition comprises, by mass, 3 parts of glossy privet fruit, 8 parts of black sesame, 9 parts of ginkgo leaf, 9 parts of ligusticum wallichii, 10 parts of white peony root, 9 parts of acanthopanax, 6 parts of eucommia ulmoides, 10 parts of poria cocos, 7 parts of dandelion, 6 parts of red date powder, 4 parts of pangolin scales, 4 parts of ricepaper pith, 6 parts of motherwort, 3 parts of donkey-hide gelatin, 10 parts of loofah sponge, 9 parts of prepared rehmannia root, 3 parts of rhodiola rosea, 3 parts of fructus alpiniae oxyphyllae, 3 parts of polygala tenuifolia, 3 parts of polygonum multiflorum, 9 parts of gordon euryale seed, 6 parts of lucid ganoderma, 6 parts of wolfberry fruit, 9 parts of astragalus membranaceus and 3 parts of rhizoma acori graminei.
Then 0.012 parts of folic acid, 80 parts of Chinese herbal medicine powder L5, 20 parts of food material powder P1 and 3 parts of milk mineral salt are taken and added into a stirrer to be uniformly mixed to obtain the composition powder.
Auxiliary materials are selected, the mass of the auxiliary materials accounts for 29 percent of the powder of the composition, and the auxiliary materials specifically comprise 23.5 percent of microcrystalline cellulose, 5 percent of sodium carboxymethyl starch and 0.5 percent of magnesium stearate. Adding the composition powder, microcrystalline cellulose and sodium carboxymethyl starch into a stirrer, uniformly mixing to obtain composition powder, granulating with 60% ethanol, drying, grading, adding magnesium stearate, and mixing to obtain composition granule.
Adding the total mixed granules of the composition into a full-automatic capsule filling machine, using 0# standard hydroxypropyl methyl cellulose (HPMC) vegetal capsules, filling 0.4g of the total mixed granules of the composition into each capsule, performing full-automatic filling, and removing fine powder adsorbed on the outer wall of the capsule on a capsule polishing machine after the filling is finished so as to ensure that the surface of the capsule is smooth and bright.
And then, performing quality inspection on the capsules, and packaging to obtain a composition product, which is marked as B3.
The methods for preparing the different dosage forms in examples 1-12 and comparative examples 1-3 above all employed conventional technical means; the raw materials and the amounts used in the examples and comparative examples are shown in Table 3 below.
TABLE 3 raw materials, amounts and dosage forms for preparing a memory enhancing composition suitable for postpartum women
Figure BDA0002311320950000141
In order to verify that the composition prepared by the invention has the effect of enhancing the memory of postpartum women, the human body eating trial test and the results of the composition are given below by referring to the method and the operating rules given in the 2 human body eating trial test of the examination method for improving the memory function in the evaluation method for assisting the memory improvement function (survey of solicited comments) -evaluation test items of health food, test principles and result judgment.
The testers and groups: 760 parturients, born within one year of age 25-40, were randomized into 19 groups of 40 individuals each.
The test method comprises the following steps: the first 12 groups were test groups, and the compositions S1 to S12 prepared in examples 1 to 12 were administered; groups 13-15 are control groups, and compositions B1-B3 prepared in comparative examples 1-3 are administered; groups 16-19 were model groups and were administered placebo, with group 16 being administered capsule placebo T1, group 17 being administered tablet placebo T2, group 18 being administered granule placebo T3, and group 19 being administered drop placebo T4. For capsule and tablet, 2 capsules are taken after meal every day, 3 times every day, and 30 days are taken continuously; for the dripping pill, 4 pills are taken after each day, 3 times a day, and the pills are continuously taken for 30 days; the granule is administered 3 times daily at a dose of 0.8g after meal for 30 days.
The test contents are as follows: the test includes pointing memory, associative learning, image free memory, meaningless graph recognition and portrait character contact memory.
Observation indexes are as follows: and (1) safety indexes. Generally, the examination includes mental, sleep, diet, defecation, blood pressure, etc.; in addition, routine examination of blood and urine, liver and kidney function examination, electrocardiogram, chest X-ray, B-ultrasonic examination of abdomen, etc. are performed. (2) efficacy index. Clinical memory scales were used. And testing the original sub-scale by using the tested sub-scales, adding the sub-scale to obtain a total scale, and testing the memory quotient by using the total scale.
And (3) test results: comparison of blood routine, urine routine and stool routine results before and after eating
Figure BDA0002311320950000151
As shown in Table 4 below, the results of biochemical index, chest X-ray, B-ultrasonic examination of abdomen and electrocardiographic examination of the eaters before and after eating the meal were compared
Figure BDA0002311320950000152
Figure BDA0002311320950000153
As shown in Table 5 below, the test amount and memory quotient before and after the test group was eaten
Figure BDA0002311320950000154
As shown in Table 6 below, the test scale and memory quotient before and after the control group and the model group were measured
Figure BDA0002311320950000155
As shown in table 7 below.
Figure BDA0002311320950000161
Figure BDA0002311320950000171
Figure BDA0002311320950000181
Figure BDA0002311320950000191
Figure BDA0002311320950000201
Figure BDA0002311320950000211
As can be seen from tables 4 and 5, after the test, control and model subjects ate for 30 days, the urine routine, blood routine and biochemical indexes are all within the normal range, and the chest X-ray, electrocardiogram and B-ultrasonic examination of the abdomen are also within the normal range, which indicates that the safety of the test sample is good.
As can be seen from tables 6 and 7, after the test groups took the compositions prepared in the examples, each was higher than before the test food, and the difference was very significant; there was no significant difference between the control group and the model group after the placebo group. The composition prepared by the technical scheme of the invention can obviously improve the memory of postpartum women.
As can be seen from the test results of the test groups in Table 6, the improved effect of S1 is the best, which indicates that the combination of folic acid and mineral salts of Chinese herbs, food materials and milk and the proper dosage ratio endow the composition with better effect. Compared with S1 and S2, the consumption of folic acid is reduced; S3-S12 change the dosage of folic acid, chinese herbal medicine powder and food material powder, and the specific raw material dosage and proportion in the preparation of the Chinese herbal medicine powder and the food material powder, and the effect is slightly worse than that of S1. Therefore, the optimal synergistic effect is achieved by optimizing the dosage and the proportion of the folic acid, the Chinese herbal medicine powder, the food material powder and the milk mineral salt, and the effect of the composition can be further improved.
As can be seen from the test results of the control group in table 7, the types and the amounts of the raw materials used in the compositions B1 and B2 obtained in the comparative example are not within the technical scope of the present invention, and the folic acid, the Chinese herbal medicine powder, the food material powder, and the milk mineral salt do not achieve a synergistic effect, so that the memory improvement effect for postpartum women is poor. The composition B3 obtained in the comparative example 3 has a poor effect of improving memory of postpartum women, and compared with the composition S1, the composition B3 is different from the composition S1 in that the types and components of the raw materials for preparing the Chinese herbal medicine powder are changed, so that the composition obtained by matching the types and components of the Chinese herbal medicines has a better effect.
Therefore, the composition has good effects on improving the memory of the postpartum female, recovering the physical condition of the postpartum female and the like.
The postpartum women who take the compositions S1-S12 in the test group are revisited after one year, and the body and spirit conditions of all the puerperae are found to be stable, the memory does not decline again, and the composition has a lasting effect and is not easy to rebound.
The test result shows that the composition prepared by the invention can effectively enhance the memory of postpartum women, has good safety in taking and is suitable for long-term taking.
In a word, the food material, the Chinese herbal medicine and the milk mineral salt are matched with the folic acid, so that the physical and psychological states of the lying-in women can be improved comprehensively from the aspects of nutrition supply, qi and blood circulation improvement, trace elements supply and the like, the lying-in women can concentrate more attention, and the symptom of memory decline is improved.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, so any modifications, equivalents, improvements and the like made within the spirit of the present invention should be included in the scope of the present invention.

Claims (7)

1. The composition for enhancing memory for postpartum women is characterized in that the composition comprises the following components in parts by mass: 0.001-0.024 part of folic acid, 25-120 parts of Chinese herbal medicine powder, 1-4 parts of milk mineral salt and 10-50 parts of food material;
the Chinese herbal medicine powder is obtained by extracting Chinese herbal medicines, wherein the Chinese herbal medicines comprise the following components in parts by mass: 5-10 parts of glossy privet fruit, 4-9 parts of black sesame, 5-13 parts of codonopsis pilosula, 6-10 parts of arillus longan, 6-13 parts of spina date seed, 7-15 parts of acanthopanax, 4-8 parts of eucommia ulmoides, 6-11 parts of poria cocos, 3-9 parts of dandelion, 4-9 parts of red date powder, 3-9 parts of pangolin, 2-5 parts of ricepaperplant pith, 4-8 parts of motherwort, 2-8 parts of donkey-hide gelatin and 5-12 parts of loofah sponge; 3-15 parts of prepared rehmannia root, 1-6 parts of rhodiola rosea, 1-10 parts of fructus alpiniae oxyphyllae, 1-10 parts of polygala tenuifolia, 1-6 parts of polygonum multiflorum, 3-15 parts of gordon euryale seed, 2-12 parts of lucid ganoderma, 2-12 parts of wolfberry fruit, 3-30 parts of astragalus mongholicus and 1-10 parts of rhizoma acori graminei;
the food material comprises the following components in parts by mass: 3-5 parts of solid rice wine, 10-15 parts of glutinous rice flour, 2-15 parts of crucian powder, 7-9 parts of shrimp meal, 5-25 parts of fruit and vegetable powder, 3-18 parts of beef powder and 3-20 parts of chicken powder.
2. The composition of claim 1, wherein: the application of the composition in preparing a medicine for enhancing memory suitable for postpartum women.
3. A process for preparing a composition according to claim 1 or 2, comprising the steps of:
(1) Decocting the Chinese medicinal materials in water, filtering, concentrating, and drying to obtain Chinese medicinal powder;
(2) Grinding the components in the food material into granules, and uniformly mixing the granules according to the proportion to obtain food material powder;
(3) Mixing the Chinese herbal medicine powder, the food material powder, the milk mineral salt and the folic acid uniformly to obtain composition powder;
(4) Preparing the composition powder into a composition with a certain dosage form according to certain dosage form requirements;
(5) And (4) performing quality inspection on the molded composition and packaging.
4. A process for preparing a composition according to claim 3, wherein: the Chinese herbal medicines in the step (1) are soaked in water for 5-30 minutes before being decocted.
5. A process for preparing a composition according to claim 3, wherein: the relative density of the concentrated filtrate in the step (1) is 1.10-1.25g/cm 3 。
6. A process for preparing a composition according to claim 3, wherein: and (3) auxiliary materials are added, wherein the auxiliary materials comprise one or more of a disintegrating agent, a lubricating agent, an adhesive, a diluent, a coloring agent, an absorbent, a bacteriostatic agent and an antioxidant.
7. A process for preparing a composition according to claim 3, wherein: the dosage form of the composition prepared in the step (4) comprises one or more of tablets, capsules, granules and dropping pills.
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