CN108669403A - A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method - Google Patents
A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method Download PDFInfo
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- CN108669403A CN108669403A CN201810523480.8A CN201810523480A CN108669403A CN 108669403 A CN108669403 A CN 108669403A CN 201810523480 A CN201810523480 A CN 201810523480A CN 108669403 A CN108669403 A CN 108669403A
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- effervescent tablet
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 55
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 41
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 37
- IHBCFWWEZXPPLG-UHFFFAOYSA-N [Ca].[Zn] Chemical compound [Ca].[Zn] IHBCFWWEZXPPLG-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 239000002245 particle Substances 0.000 claims abstract description 41
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000005018 casein Substances 0.000 claims abstract description 30
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 30
- 235000021240 caseins Nutrition 0.000 claims abstract description 30
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 28
- 108010001441 Phosphopeptides Proteins 0.000 claims abstract description 27
- 229940088594 vitamin Drugs 0.000 claims abstract description 27
- 229930003231 vitamin Natural products 0.000 claims abstract description 27
- 235000013343 vitamin Nutrition 0.000 claims abstract description 27
- 239000011782 vitamin Substances 0.000 claims abstract description 27
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 27
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 26
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 23
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 20
- 239000008101 lactose Substances 0.000 claims abstract description 20
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 18
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 18
- 229930195725 Mannitol Natural products 0.000 claims abstract description 18
- 239000000594 mannitol Substances 0.000 claims abstract description 18
- 235000010355 mannitol Nutrition 0.000 claims abstract description 18
- 239000011734 sodium Substances 0.000 claims abstract description 18
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 18
- 229920002689 polyvinyl acetate Polymers 0.000 claims abstract description 17
- 239000011118 polyvinyl acetate Substances 0.000 claims abstract description 17
- MKWYFZFMAMBPQK-UHFFFAOYSA-J sodium feredetate Chemical compound [Na+].[Fe+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O MKWYFZFMAMBPQK-UHFFFAOYSA-J 0.000 claims abstract description 17
- 239000013522 chelant Substances 0.000 claims abstract description 16
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 claims abstract description 16
- GIPOFCXYHMWROH-UHFFFAOYSA-L 2-aminoacetate;iron(2+) Chemical compound [Fe+2].NCC([O-])=O.NCC([O-])=O GIPOFCXYHMWROH-UHFFFAOYSA-L 0.000 claims abstract description 15
- 229940086413 ferrous bisglycinate Drugs 0.000 claims abstract description 15
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 14
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 14
- 239000011975 tartaric acid Substances 0.000 claims abstract description 14
- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 14
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 14
- 239000011718 vitamin C Substances 0.000 claims abstract description 14
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims abstract description 13
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 13
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims abstract description 13
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 13
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 13
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 13
- 235000013985 cinnamic acid Nutrition 0.000 claims abstract description 13
- 229930016911 cinnamic acid Natural products 0.000 claims abstract description 13
- 229960000304 folic acid Drugs 0.000 claims abstract description 13
- 235000019152 folic acid Nutrition 0.000 claims abstract description 13
- 239000011724 folic acid Substances 0.000 claims abstract description 13
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 13
- 239000011719 vitamin A Substances 0.000 claims abstract description 13
- 229940045997 vitamin a Drugs 0.000 claims abstract description 13
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 10
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 10
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 10
- 239000011710 vitamin D Substances 0.000 claims abstract description 10
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 10
- 229940046008 vitamin d Drugs 0.000 claims abstract description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 9
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 9
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 8
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 229960003511 macrogol Drugs 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims description 33
- 238000002156 mixing Methods 0.000 claims description 20
- 239000011122 softwood Substances 0.000 claims description 20
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 16
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- MKJXYGKVIBWPFZ-CEOVSRFSSA-L calcium;(2s)-2-hydroxypropanoate Chemical compound [Ca+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O MKJXYGKVIBWPFZ-CEOVSRFSSA-L 0.000 claims description 10
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 8
- 235000019158 vitamin B6 Nutrition 0.000 claims description 8
- 239000011726 vitamin B6 Substances 0.000 claims description 8
- 229940011671 vitamin b6 Drugs 0.000 claims description 8
- 229930003779 Vitamin B12 Natural products 0.000 claims description 7
- 235000019163 vitamin B12 Nutrition 0.000 claims description 7
- 239000011715 vitamin B12 Substances 0.000 claims description 7
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- 229930003451 Vitamin B1 Natural products 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 238000002203 pretreatment Methods 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 229960003495 thiamine Drugs 0.000 claims description 5
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 5
- 235000010374 vitamin B1 Nutrition 0.000 claims description 5
- 239000011691 vitamin B1 Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims 1
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- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims 1
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- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 18
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- 229910052791 calcium Inorganic materials 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 11
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- 238000010521 absorption reaction Methods 0.000 description 8
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- 239000008280 blood Substances 0.000 description 1
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- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
- 150000007528 brønsted-lowry bases Chemical class 0.000 description 1
- 102000014823 calbindin Human genes 0.000 description 1
- 108060001061 calbindin Proteins 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229940022769 d- lactic acid Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- KFZAUHNPPZCSCR-UHFFFAOYSA-N iron zinc Chemical compound [Fe].[Zn] KFZAUHNPPZCSCR-UHFFFAOYSA-N 0.000 description 1
- TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000001557 mycostatic effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000013464 vaginal disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
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- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation methods,It is related to effervescent tablet field,It is made of following parts by weight of component,100 200 parts of tartaric acid,10 20 parts of citric acid,30 70 parts of sodium carbonate,30 70 parts of anhydrous sodium bicarbonate,150 250 parts of lactose,100 200 parts of mannitol,20 30 parts of polyvinylpyrrolidone,10 30 parts of polyvinyl acetate,5 15 parts of Macrogol 4000,15 parts of cinnamic acid,0.05 0.1 parts of vitamin A,0.1 0.2 parts of vitamin B1,0.1 0.15 parts of vitamin B6,0.0002 0.0004 parts of vitamin B12,5 15 parts of vitamin C,0.0003 0.0007 parts of vitamin D,1.8 parts of vitamin e1,0.02 0.06 parts of folic acid,35 45 parts of L calcium lactates,0.5 1.5 parts of ferrous bisglycinate chelate,0.2 0.6 parts of NaFeEDTA sodium,0.3 0.9 parts of zinc-amino acid chelate,5 10 parts of casein phosphopeptide.Include the following steps, the preparation of active ingredient；The preparation of B particles；The preparation of C particles；Mixed pressuring plate.Stability of the present invention is good, and beneficiating ingredient is high, good health care effect, and bioavilability is high, in good taste, and quality is high, there is good market value.
Description
Technical field
The present invention relates to health food effervescent tablet and preparation method thereof technical fields, and in particular to a kind of iron content zinc calcium is a variety of
The effervescent tablet of vitamin and its annular preparation and preparation method.
Background technology
Vitamin is a series of general designation of organic compounds.They are the required micro-nutrient compositions of organism, and one
As again can not produce by organism oneself, need by the means such as diet acquisition.Vitamin cannot be as carbohydrate, protein and fat
Energy can be generated like that, form cell, the content of vitamin in vivo is seldom, but indispensable.Calcium iron zinc must as human body
The nutrient needed, the calcium constituent in human body are mainly present in the form of crystal in bone and tooth, and calcium is in addition to being skeleton development
Base stock, directly affect outside height, also to ensure being smoothed out for normal growth and development play an important roll.Ferro element is
One of the essential element of human body is constituted, iron deficiency influences whether health and the development of human body, and maximum influence is iron deficiency
Property anaemia, ferro element promotes the growth and development of human body, maintains human normal appetite, enhance human immunity, promote wound and wound
The healing of wound, the metabolism for influencing vitamin A and normal vision, the maintenance normal spermatogenesis of male etc..
Effervescent tablet is a kind of newer pharmaceutical dosage form in China, different from conventional tablet, and effervescent tablet utilizes organic bronsted lowry acids and bases bronsted lowry
Formula carbonic acid (hydrogen) reactant salt does gas-producing disintegrant, is placed in water, occurs immediately upon effervesce reaction, generates and discharge a large amount of titanium dioxide
Carbon gas, for shape as boiled, therefore named effervescent tablet has the aesthetic feeling as carbonated drink when drinking-water being made to drink in entrance.Effervescent tablet has following excellent
Point：Rich in vitamin c, contribute to the absorption of iron, maintains skin and mucous membrane health etc..Convenient for preserving and carrying.Effervescent tablet collapses
Solve quick, convenient to take, action rapidly.Bioavilability is high, can improve clinical efficacy.Especially suitable for children, the elderly with
And swallow the patient of pill difficulty.By seasoned effervescent tablet, more preferably, good medicine is no longer bitter to the taste for taste, and patient is made more to be happy to connect
By.Since a large amount of foams that disintegration generates increase being in direct contact for drug and diseased region, the effect of its curative effect is preferably played,
So effervescent tablet is additionally operable to the prevention medication of vaginal disease etc..There is production and sales vitamin effervescent tablet currently on the market, but contains
The effervescent tablet of the nutrients such as calcium iron zinc is rarely reported.
Greatest problem existing for the effervescent tablet of production and sales currently on the market is exactly sticking problem, effervescent tablet be easy moisture absorption and
Failure.Existing Effervescent tablet disintegration speed is 1-5min, works as adding ingredient, disintegration rate slows down, and consumer can lose effervescent tablet
Go patience, the market value of effervescent tablet that will have a greatly reduced quality.In human body, the divalent ions such as calcium, iron, zinc, lead, they need to make
With same carrier, calcium, iron, zinc same added time, since the activity of calcium is all stronger than iron and zinc, absolute magnitude is also more than iron, zinc, obtains
The ability of carrier is much better than iron and zinc, so calcium, iron, zinc arrive calcium with mending only only to mend, and iron and zinc be basically can not
It mends.And show by multinomial experiment to take the calcium, iron, zinc preparation of plyability according to many medicine and nutrition expert, by
Different ions and different acid groups are resolved into these compounds in gastrointestinal tract, it is from each other it is possible that stronger mutual
Displacement, inhibits the effect absorbed at combination, to increase gastrointestinal irritation and side effect.In addition, need that disintegrant is added in effervescent tablet,
The acid source of disintegrant can form insoluble molysite with nonheme iron and prevent the absorption of iron.
Invention content
Technical problem to be solved by the present invention lies in providing, a kind of stability is good, and beneficiating ingredient is high, good health care effect, raw
Object availability is high, in good taste, and quality is high, easy to use, there is the multivitamin effervesce of iron content zinc calcium of good market value
Piece and its annular preparation and preparation method.
A kind of multivitamin effervescent tablet of iron content zinc calcium, is made of following parts by weight of component：100-200 parts of tartaric acid,
10-20 parts of citric acid, 30-70 parts of sodium carbonate, 30-70 parts of anhydrous sodium bicarbonate, 150-250 parts of lactose, mannitol 100-200
Part, 20-30 parts of polyvinylpyrrolidone, 10-30 parts of polyvinyl acetate, 5-15 parts of Macrogol 4000,1-5 parts of cinnamic acid,
0.05-0.1 parts of vitamin A .1-0.2 parts of vitaminB10,0.1-0.15 parts of vitamin B6, vitamin B12 0.0002-0.0004
Part, 5-15 parts of vitamin C, 0.0003-0.0007 parts of vitamin D, -1.8 parts of vitamin e1,0.02-0.06 parts of folic acid, Pfansteihl
35-45 parts of calcium, 0.5-1.5 parts of ferrous bisglycinate chelate, 0.2-0.6 parts of NaFeEDTA sodium, 0.3-0.9 parts of zinc-amino acid chelate, casein
5-10 parts of phosphoeptide.
Preferably, it is made of following parts by weight of component, 150 parts of tartaric acid, 15 parts of citric acid, 50 parts of sodium carbonate, anhydrous carbon
50 parts of sour hydrogen sodium, 200 parts of lactose, 150 parts of mannitol, 25 parts of polyvinylpyrrolidone, 20 parts of polyvinyl acetate, polyethylene glycol
400010 parts, 3 parts of cinnamic acid, 0.075 part of vitamin A .15 parts of vitaminB10,0.125 part of vitamin B6, vitamin
B120.0003 parts, 10 parts of vitamin C, 0.0005 part of vitamin D .4 parts of vitamin e1,0.04 part of folic acid, 40 parts of L-calcium lactate,
1 part of ferrous bisglycinate chelate, 0.4 part of NaFeEDTA sodium, 0.6 part of zinc-amino acid chelate, 7.5 parts of casein phosphopeptide.
Mannitol of the present invention is a kind of hexitol, and when dissolving absorbs heat, pleasantly sweet, has comfort sense to oral cavity, is carried out with lactose
Proportioning is used as diluent, reduces the hygroscopicity of lactose, increases the compressibility of effervescent tablet, is easy granulation, dissolubility is good, not will produce
Insoluble matter.Polyethylene glycol of the present invention is the polymer that ethylene oxide hydrolyzes product, nontoxic, nonirritant as a kind of lubricant,
It is widely used in various pharmaceutical preparations, for sticking problem in tableting processes, the anti-sticking effect of Macrogol 4000 is good, invariably
Molten object, without foaming phenomena, smooth appearance, improve the market value of effervescent tablet.
As acid source, sodium carbonate, anhydrous sodium bicarbonate have good stabilization as alkali source for citric acid of the present invention, tartaric acid
Property and compatibility.Cinnamic acid of the present invention is antimycotic active material, has and presses down mycostatic effect, citric acid and Chinese cassia tree well
The addition of aldehyde keeps the mouthfeel of effervescent tablet more preferable, helps to be metabolized, and improves appetite, is more vulnerable to the welcome of consumer.
L-calcium lactate of the present invention is a kind of organic calcium, and free from extraneous odour, solubility is better than calcium lactate, is absorption of human body in calcium constituent
In the case of, D-lactic acid can adjust microcirculation in human body, without the fermentation acid smell of DL-LACTIC ACID calcium, compared with DL-LACTIC ACID calcium phase ratio
There is the use value of bigger.The major function of vitamin D is to adjust internal Ca,P metabolism, maintains the level of blood calcium and serium inorganic phosphorus, from
And the normal growth of tooth and bone is maintained just to develop, and vitamin D can induce intestinal mucosa generation one kind of many animals specially
One calbindin (CaBP) increases permeability of the animal intestinal mucosa to calcium ion, promotes the absorption of calcium in the intestine.The present invention
Casein phosphopeptide is energy and calcium under neutral and weakly alkaline environment by biologically active polypeptide made from biotechnology
In conjunction with inhibiting the generation of infusible precipitate, avoid the loss of calcium, finally the Passive intake due to raising of free calcium concentration.In addition
Absorption and utilization of the human body to the divalent minerals nutrient such as calcium, iron, zinc can be effectively facilitated.
The nutritional ingredients such as ferrous bisglycinate chelate of the present invention, NaFeEDTA sodium, zinc-amino acid chelate, using biological chelating technology, with
Small molecule state enters into the cell, and absorbing path is not competed with other nutrients, and absorptivity is higher than other chalybeates and zinc agent.Wherein
Ferrous bisglycinate chelate can form overstable chelate structure, to greatly improve absorptivity of the human body to iron.NaFeEDTA sodium, property are steady
Fixed solvay-type ferrous-fortifier is the melt quality replenishers of most foreground.Vitamin C and iron scientific matching, effectively facilitate iron
It absorbs.Zinc-amino acid chelate supplements Zn-ef ficiency using the driving source of living organism, safe, non-stimulated, makes zinc and amino acid together
It is absorbed by the body, absorptivity can be greatly improved.And glycin chelated iron and zinc-amino acid chelate stable structure, when dissolving, do not disappear
Hydrochloric acid in gastric juice is consumed, stimulating intestine and stomach, will not cause to get angry, will not be influenced to absorb by the interference of food in vivo.
A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method, include the following steps：
(1) pre-treatment of casein phosphopeptide：Casein phosphopeptide is carried out using the ultraviolet lamp that wavelength is 255-365nm
Casein phosphopeptide 1 is made in ultraviolet processing 5-10min；
Casein phosphopeptide of the present invention is by biologically active polypeptide made from biotechnology, and the present invention is to junket egg
White phosphoeptide carries out ultraviolet processing, peptide chain generation property due to largely absorbing ultraviolet light becomes, and destroyed physiological activity makes in cell
The structure and property in divalent ion channel change, to be conducive to the absorption of calcium iron zinc.
(2) preparation of active ingredient：By vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, dimension life
Junket egg made from plain D, vitamin E, folic acid, L-calcium lactate, ferrous bisglycinate chelate, NaFeEDTA sodium, zinc-amino acid chelate and step (1)
1 mixing of white phosphoeptide, sieves with 100 mesh sieve to obtain part A；
(3) preparation of B particles：Lactose, mannitol, polyvinylpyrrolidine is added in tartaric acid, citric acid after mixing
Then softwood is made in ketone, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain B particles；
(4) preparation of C particles：Lactose, mannitol, polyethylene is added in sodium carbonate, anhydrous sodium bicarbonate after mixing
Then softwood is made in pyrrolidones, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain C
Particle；
(5) mixed pressuring plate：Part A made from step (2) and cinnamic acid are uniformly mixed, polyethylene glycol is then added
4000, B particles made from step (3), C particles made from step (4) are made using ring mould tabletting after mixing
Annular preparation.
Annular preparation is made in the effervescent tablet of the present invention, increases surface area, can effectively accelerate disintegration rate,
Further, the drying temperature control in the step (2) is 40-50 DEG C, B particles after step (2) drying
Moisture content be 0.5-1%.
Further, the drying temperature control in the step (3) is 40-50 DEG C, C particles after step (3) drying
Moisture content be 0.5-1%.
When drying temperature of the present invention is less than 40 DEG C, moisture content is extremely difficult to 0.5-1%, if drying time is long, material holds
Easy to moisture absorption, when drying temperature is higher than 50 DEG C, the stabilization of sodium carbonate will be affected, easily rapid to decompose.
Further, the pressure control of ring mould tabletting is 4-6kg/cm in the step (4)2。
The pressure of tabletting of the present invention is less than 4kg/cm2When, effervesce tablet preparation obtained, hardness is inadequate, dissolves and dissipates block, tabletting
Pressure be more than 6kg/cm2When, effervescent agent hardness obtained is excessive, can reduce disintegration rate.
The beneficial effects of the invention are as follows：Stability of the present invention is good, and beneficiating ingredient is high, good health care effect, and bioavilability is high,
In good taste, quality is high, easy to use, there is good market value.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1
A kind of multivitamin effervescent tablet of iron content zinc calcium, is made of following parts by weight of component：100 parts of tartaric acid, lemon
Acid 10 parts, 30 parts of sodium carbonate, 30 parts of anhydrous sodium bicarbonate, 150 parts of lactose, 100 parts of mannitol, 20 parts of polyvinylpyrrolidone,
10 parts of polyvinyl acetate, 5 parts of Macrogol 4000,1 part of cinnamic acid, 0.05 part of vitamin A .1 parts of vitaminB10, vitamin
B60.1 parts, 0.0002 part of vitamin B12,5 parts of vitamin C, 0.0003 part of vitamin D, vitamin e1 part, 0.02 part of folic acid, L-
35 parts of calcium lactate, 0.5 part of ferrous bisglycinate chelate, 0.2 part of NaFeEDTA sodium, 0.3 part of zinc-amino acid chelate, 5 parts of casein phosphopeptide.
A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method, which is characterized in that including
Following steps：
(1) pre-treatment of casein phosphopeptide：Casein phosphopeptide is carried out using the ultraviolet lamp that wavelength is 255nm ultraviolet
5min is handled, casein phosphopeptide 1 is made；
(2) preparation of active ingredient：By vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, dimension life
Junket egg made from plain D, vitamin E, folic acid, L-calcium lactate, ferrous bisglycinate chelate, NaFeEDTA sodium, zinc-amino acid chelate and step (1)
1 mixing of white phosphoeptide, sieves with 100 mesh sieve to obtain part A；
(3) preparation of B particles：Lactose, mannitol, polyvinylpyrrolidine is added in tartaric acid, citric acid after mixing
Then softwood is made in ketone, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain B particles；
(4) preparation of C particles：Lactose, mannitol, polyethylene is added in sodium carbonate, anhydrous sodium bicarbonate after mixing
Then softwood is made in pyrrolidones, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain C
Particle；
(5) mixed pressuring plate：Part A made from step (2) and cinnamic acid are uniformly mixed, polyethylene glycol is then added
4000, B particles made from step (3), C particles made from step (4) are made using ring mould tabletting after mixing
Annular preparation.
Drying temperature control in step (2) is 40 DEG C, and the moisture content of B particles is 0.5% after step (2) drying.
Drying temperature control in step (3) is 40 DEG C, and the moisture content of C particles is 0.5% after step (3) drying.
The pressure control of ring mould tabletting in step (4) is 4kg/cm2。
Embodiment 2
A kind of multivitamin effervescent tablet of iron content zinc calcium, is made of following parts by weight of component：150 parts of tartaric acid, lemon
Acid 15 parts, 50 parts of sodium carbonate, 50 parts of anhydrous sodium bicarbonate, 200 parts of lactose, 150 parts of mannitol, 25 parts of polyvinylpyrrolidone,
20 parts of polyvinyl acetate, 10 parts of Macrogol 4000,3 parts of cinnamic acid, 0.075 part of vitamin A .15 parts of vitaminB10, dimension
Raw B60.125 parts of element, 0.0003 part of vitamin B12,10 parts of vitamin C, 0.0005 part of vitamin D .4 parts of vitamin e1, folic acid
0.04 part, 40 parts of L-calcium lactate, 1 part of ferrous bisglycinate chelate, 0.4 part of NaFeEDTA sodium, 0.6 part of zinc-amino acid chelate, casein phosphoric acid
7.5 parts of peptide.
A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method, which is characterized in that including
Following steps：
(1) pre-treatment of casein phosphopeptide：Casein phosphopeptide is carried out using the ultraviolet lamp that wavelength is 310nm ultraviolet
7.5min is handled, casein phosphopeptide 1 is made；
(2) preparation of active ingredient：By vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, dimension life
Junket egg made from plain D, vitamin E, folic acid, L-calcium lactate, ferrous bisglycinate chelate, NaFeEDTA sodium, zinc-amino acid chelate and step (1)
1 mixing of white phosphoeptide, sieves with 100 mesh sieve to obtain part A；
(3) preparation of B particles：Lactose, mannitol, polyvinylpyrrolidine is added in tartaric acid, citric acid after mixing
Then softwood is made in ketone, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain B particles；
(4) preparation of C particles：Lactose, mannitol, polyethylene is added in sodium carbonate, anhydrous sodium bicarbonate after mixing
Then softwood is made in pyrrolidones, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain C
Particle；
(5) mixed pressuring plate：Part A made from step (2) and cinnamic acid are uniformly mixed, polyethylene glycol is then added
4000, B particles made from step (3), C particles made from step (4) are made using ring mould tabletting after mixing
Annular preparation.
Drying temperature control in step (2) is 45 DEG C, and the moisture content of B particles is 0.75% after step (2) drying.
Drying temperature control in step (3) is 45 DEG C, and the moisture content of C particles is 0.75% after step (3) drying.
The pressure control of ring mould tabletting in step (4) is 5kg/cm2。
Embodiment 3
A kind of multivitamin effervescent tablet of iron content zinc calcium, is made of following parts by weight of component：200 parts of tartaric acid, lemon
Acid 20 parts, 70 parts of sodium carbonate, 70 parts of anhydrous sodium bicarbonate, 250 parts of lactose, 200 parts of mannitol, polyvinylpyrrolidone 30 part,
30 parts of polyvinyl acetate, 15 parts of Macrogol 4000,5 parts of cinnamic acid, 0.1 part of vitamin A .2 parts of vitaminB10, vitamin
B60.15 parts, 0.0004 part of vitamin B12,15 parts of vitamin C, 0.0007 part of vitamin D .8 parts of vitamin e1, folic acid 0.06
Part, Pfansteihl Ca45 part, 1.5 parts of ferrous bisglycinate chelate, 0.6 part of NaFeEDTA sodium, 0.9 part of zinc-amino acid chelate, casein phosphopeptide
10 parts.
A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method, which is characterized in that including
Following steps：
(1) pre-treatment of casein phosphopeptide：Casein phosphopeptide is carried out using the ultraviolet lamp that wavelength is 365nm ultraviolet
10min is handled, casein phosphopeptide 1 is made；
(2) preparation of active ingredient：By vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, dimension life
Junket egg made from plain D, vitamin E, folic acid, L-calcium lactate, ferrous bisglycinate chelate, NaFeEDTA sodium, zinc-amino acid chelate and step (1)
1 mixing of white phosphoeptide, sieves with 100 mesh sieve to obtain part A；
(3) preparation of B particles：Lactose, mannitol, polyvinylpyrrolidine is added in tartaric acid, citric acid after mixing
Then softwood is made in ketone, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain B particles；
(4) preparation of C particles：Lactose, mannitol, polyethylene is added in sodium carbonate, anhydrous sodium bicarbonate after mixing
Then softwood is made in pyrrolidones, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain C
Particle；
(5) mixed pressuring plate：Part A made from step (2) and cinnamic acid are uniformly mixed, polyethylene glycol is then added
4000, B particles made from step (3), C particles made from step (4) are made using ring mould tabletting after mixing
Annular preparation.
Drying temperature control in step (2) is 50 DEG C, and the moisture content of B particles is 1% after step (2) drying.
Drying temperature control in step (3) is 50 DEG C, and the moisture content of C particles is 1% after step (3) drying.
The pressure control of ring mould tabletting in step (4) is 6kg/cm2。
Comparative example 1
This comparative example 1 compared with Example 2, saves the casein phosphopeptide 1 in step (1) and step (2), removes this
Outer method and step all same.
Comparative example 2
This comparative example 2 compared with Example 2, saves step (1), and the casein phosphopeptide 1 in step (2) is changed into
Carry out the casein phosphopeptide before step (1) is handled, method and step all same in addition to this.
Comparative example 3
This comparative example 3 compared with Example 2, saves the NaFeEDTA sodium in step (2), and method and step in addition to this is equal
It is identical.
Comparative example 4
This comparative example 4 compared with Example 2, saves step (1), casein phosphopeptide 1 and step in step (2)
(2) the NaFeEDTA sodium in, method and step all same in addition to this
Control group
Application No. is the multivitamin effervescent tablet of iron content zinc calcium disclosed in 200410060949.7 and its annular preparation with
Preparation method.
In order to compare effect of the present invention, select made from the method for the present invention with the multivitamin effervesce of a collection of iron content zinc calcium
The annular preparation of piece as experimental subjects, respectively use above-described embodiment 1,
Embodiment 2, embodiment 3, comparative example 1, comparative example 2, comparative example 3, comparative example 4, control
The method of group is detected, and the correction data of corresponding detection is as shown in table 1 below：
Table 1
From above table as can be seen that compared with the effervescent tablet with control group, the present invention has the apparent holding time long
The characteristics of, and beneficiating ingredient is high, and the bioavilability of beneficiating ingredient is high, has better health-care effect, while easy to use,
Disintegration rate is fast, and mouthfeel is more preferable, it is easier to obtain the approval of consumer, there is very high market value.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (6)
1. a kind of multivitamin effervescent tablet of iron content zinc calcium, which is characterized in that be made of following parts by weight of component：Tartaric acid
100-200 parts, 10-20 parts of citric acid, 30-70 parts of sodium carbonate, 30-70 parts of anhydrous sodium bicarbonate, 150-250 parts of lactose, sweet dew
100-200 parts of alcohol, 20-30 parts of polyvinylpyrrolidone, 10-30 parts of polyvinyl acetate, 5-15 parts of Macrogol 4000, meat
1-5 parts of cinnamic aldehyde, 0.05-0.1 parts of vitamin A, 0.1-0.2 parts of vitamin B1,0.1-0.15 parts of vitamin B6, vitamin B12
0.0002-0.0004 parts, 5-15 parts of vitamin C, 0.0003-0.0007 parts of vitamin D, -1.8 parts of vitamin e1, folic acid 0.02-
0.06 part, 35-45 parts of L-calcium lactate, 0.5-1.5 parts of ferrous bisglycinate chelate, 0.2-0.6 parts of NaFeEDTA sodium, zinc-amino acid chelate 0.3-
0.9 part, 5-10 parts of casein phosphopeptide.
2. the multivitamin effervescent tablet of iron content zinc calcium according to claim 1, which is characterized in that by following parts by weight group
Divide and is made：150 parts of tartaric acid, 15 parts of citric acid, 50 parts of sodium carbonate, 50 parts of anhydrous sodium bicarbonate, 200 parts of lactose, mannitol 150
Part, 25 parts of polyvinylpyrrolidone, 20 parts of polyvinyl acetate, 10 parts of Macrogol 4000,3 parts of cinnamic acid, vitamin
A0.075 parts, 0.15 part of vitamin B1,0.125 part of vitamin B6,0.0003 part of vitamin B12,10 parts of vitamin C, dimension life
D0.0005 parts plain .4 parts of vitamin e1,0.04 part of folic acid, 40 parts of L-calcium lactate, 1 part of ferrous bisglycinate chelate, 0.4 part of NaFeEDTA sodium,
0.6 part of zinc-amino acid chelate, 7.5 parts of casein phosphopeptide.
3. the multivitamin effervescent tablet of iron content zinc calcium according to claim 1 or 2 and its annular preparation and preparation method,
It is characterized by comprising the following steps：
(1) pre-treatment of casein phosphopeptide：Casein phosphopeptide is carried out using the ultraviolet lamp that wavelength is 255-365nm ultraviolet
5-10min is handled, casein phosphopeptide 1 is made；
(2) preparation of active ingredient：By vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, vitamin D,
Casein phosphorus made from vitamin E, folic acid, L-calcium lactate, ferrous bisglycinate chelate, NaFeEDTA sodium, zinc-amino acid chelate and step (1)
1 mixing of sour peptide, sieves with 100 mesh sieve to obtain part A；
(3) preparation of B particles：Lactose is added in tartaric acid, citric acid after mixing, mannitol, polyvinylpyrrolidone, is gathered
Then softwood is made in vinylacetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain B particles；
(4) preparation of C particles：Lactose, mannitol, polyvinyl pyrrole is added in sodium carbonate, anhydrous sodium bicarbonate after mixing
Then softwood is made in alkanone, polyvinyl acetate, then pelletize to manufactured softwood, and 18 mesh are crossed after drying and sieve to obtain C
Grain；
(5) mixed pressuring plate：Part A made from step (2) and cinnamic acid are uniformly mixed, then add Macrogol 4000,
Loop system is made using ring mould tabletting after mixing in B particles made from step (3), C particles made from step (4)
Agent.
4. the multivitamin effervescent tablet of iron content zinc calcium according to claim 3 and its annular preparation and preparation method,
It is characterized in that, the drying temperature control in the step (3) is 40-50 DEG C, the moisture content of B particles after step (2) drying
For 0.5-1%.
5. the multivitamin effervescent tablet of iron content zinc calcium according to claim 3 and its annular preparation and preparation method,
It is characterized in that, the drying temperature control in the step (4) is 40-50 DEG C, the moisture content of C particles after step (3) drying
For 0.5-1%.
6. the multivitamin effervescent tablet of iron content zinc calcium according to claim 3 and its annular preparation and preparation method,
It is characterized in that, the pressure control of the ring mould tabletting in the step (5) is 4-6kg/cm2。
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Cited By (2)
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| CN110367425A (en) * | 2019-06-25 | 2019-10-25 | 杭州娃哈哈科技有限公司 | A kind of micro- effervescent tablet of Rosa roxburghii Tratt vitamin C and preparation method thereof |
| CN117652598A (en) * | 2024-01-25 | 2024-03-08 | 佛山市南海禅泰动物药业有限公司 | Vitamin amino acid water-soluble effervescent block and preparation method thereof |
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