CN105410904A - Calcium lactate granule composition suitable for calcium supplement for young children - Google Patents
Calcium lactate granule composition suitable for calcium supplement for young children Download PDFInfo
- Publication number
- CN105410904A CN105410904A CN201510819478.1A CN201510819478A CN105410904A CN 105410904 A CN105410904 A CN 105410904A CN 201510819478 A CN201510819478 A CN 201510819478A CN 105410904 A CN105410904 A CN 105410904A
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- China
- Prior art keywords
- calcium
- child
- parts
- applicable
- lactate
- Prior art date
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- Granted
Links
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 title claims abstract description 61
- 235000011086 calcium lactate Nutrition 0.000 title claims abstract description 61
- 239000001527 calcium lactate Substances 0.000 title claims abstract description 55
- 229960002401 calcium lactate Drugs 0.000 title claims abstract description 55
- 229940069978 calcium supplement Drugs 0.000 title abstract 3
- 239000008202 granule composition Substances 0.000 title abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 103
- 229960005069 calcium Drugs 0.000 claims abstract description 103
- 239000011575 calcium Substances 0.000 claims abstract description 103
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 103
- 239000003814 drug Substances 0.000 claims abstract description 59
- 239000000203 mixture Substances 0.000 claims abstract description 55
- 239000008187 granular material Substances 0.000 claims abstract description 35
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 210000000952 spleen Anatomy 0.000 claims abstract description 23
- 229940116298 l- malic acid Drugs 0.000 claims abstract description 22
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 20
- 239000011746 zinc citrate Substances 0.000 claims abstract description 20
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 20
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 20
- 238000005728 strengthening Methods 0.000 claims abstract description 19
- 230000001954 sterilising effect Effects 0.000 claims abstract description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 17
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000004225 ferrous lactate Substances 0.000 claims abstract description 14
- 235000013925 ferrous lactate Nutrition 0.000 claims abstract description 14
- 229940037907 ferrous lactate Drugs 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims abstract description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 13
- 239000008103 glucose Substances 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 239000005018 casein Substances 0.000 claims abstract description 8
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000021240 caseins Nutrition 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 24
- 238000007670 refining Methods 0.000 claims description 19
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 13
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 13
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 13
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 13
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 13
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 13
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 13
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 13
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 13
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 13
- 235000013399 edible fruits Nutrition 0.000 claims description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 12
- 238000000855 fermentation Methods 0.000 claims description 12
- 230000004151 fermentation Effects 0.000 claims description 12
- 230000007062 hydrolysis Effects 0.000 claims description 12
- 238000006460 hydrolysis reaction Methods 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 10
- 244000144730 Amygdalus persica Species 0.000 claims description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 7
- 241000220225 Malus Species 0.000 claims description 7
- 235000011430 Malus pumila Nutrition 0.000 claims description 7
- 235000015103 Malus silvestris Nutrition 0.000 claims description 7
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 7
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 7
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 7
- 240000006365 Vitis vinifera Species 0.000 claims description 7
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 240000004307 Citrus medica Species 0.000 claims description 6
- 235000001938 Citrus medica Nutrition 0.000 claims description 6
- 235000002555 Citrus medica var sarcodactylis Nutrition 0.000 claims description 6
- 244000077995 Coix lacryma jobi Species 0.000 claims description 6
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 6
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 6
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 6
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 6
- 241000287828 Gallus gallus Species 0.000 claims description 6
- 240000002853 Nelumbo nucifera Species 0.000 claims description 6
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 6
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 6
- 240000007594 Oryza sativa Species 0.000 claims description 6
- 235000007164 Oryza sativa Nutrition 0.000 claims description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 6
- 108010019160 Pancreatin Proteins 0.000 claims description 6
- 244000197580 Poria cocos Species 0.000 claims description 6
- 235000008599 Poria cocos Nutrition 0.000 claims description 6
- 102000004142 Trypsin Human genes 0.000 claims description 6
- 108090000631 Trypsin Proteins 0.000 claims description 6
- 240000008042 Zea mays Species 0.000 claims description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 6
- 239000007853 buffer solution Substances 0.000 claims description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 6
- 235000005822 corn Nutrition 0.000 claims description 6
- 229940088598 enzyme Drugs 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 235000013312 flour Nutrition 0.000 claims description 6
- 235000008434 ginseng Nutrition 0.000 claims description 6
- 210000004317 gizzard Anatomy 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000006386 neutralization reaction Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 229940055695 pancreatin Drugs 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 235000009566 rice Nutrition 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 239000010409 thin film Substances 0.000 claims description 6
- 239000012588 trypsin Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 240000000171 Crataegus monogyna Species 0.000 claims 2
- 244000131316 Panax pseudoginseng Species 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract description 42
- 238000010521 absorption reaction Methods 0.000 abstract description 33
- 230000000694 effects Effects 0.000 abstract description 29
- 229910052742 iron Inorganic materials 0.000 abstract description 21
- 239000011701 zinc Substances 0.000 abstract description 17
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 16
- 235000013305 food Nutrition 0.000 abstract description 16
- 229910052725 zinc Inorganic materials 0.000 abstract description 16
- 235000011090 malic acid Nutrition 0.000 abstract description 11
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract description 7
- 230000004060 metabolic process Effects 0.000 abstract description 7
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract description 3
- 229910001424 calcium ion Inorganic materials 0.000 abstract description 3
- -1 citric acid radical Chemical class 0.000 abstract description 3
- 230000029087 digestion Effects 0.000 abstract description 3
- 229940099690 malic acid Drugs 0.000 abstract description 3
- 239000001630 malic acid Substances 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 108010001441 Phosphopeptides Proteins 0.000 abstract 2
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 abstract 1
- 229940107187 fructooligosaccharide Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 241001092040 Crataegus Species 0.000 description 11
- 241000700159 Rattus Species 0.000 description 11
- 230000009286 beneficial effect Effects 0.000 description 10
- 210000000988 bone and bone Anatomy 0.000 description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 description 7
- 235000010755 mineral Nutrition 0.000 description 7
- 239000011707 mineral Substances 0.000 description 7
- 230000001256 tonic effect Effects 0.000 description 7
- 241000208340 Araliaceae Species 0.000 description 5
- 206010006956 Calcium deficiency Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229910000640 Fe alloy Inorganic materials 0.000 description 4
- 229930003316 Vitamin D Natural products 0.000 description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- KFZAUHNPPZCSCR-UHFFFAOYSA-N iron zinc Chemical compound [Fe].[Zn] KFZAUHNPPZCSCR-UHFFFAOYSA-N 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 235000019166 vitamin D Nutrition 0.000 description 4
- 239000011710 vitamin D Substances 0.000 description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 description 4
- 229940046008 vitamin d Drugs 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- SMHNUIFHMAGAFL-UHFFFAOYSA-N calcium;2-hydroxypropanoic acid Chemical compound [Ca].CC(O)C(O)=O SMHNUIFHMAGAFL-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 235000021239 milk protein Nutrition 0.000 description 2
- 239000000467 phytic acid Substances 0.000 description 2
- 229940068041 phytic acid Drugs 0.000 description 2
- 235000002949 phytic acid Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010053155 Epigastric discomfort Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940092124 calcium citrate malate Drugs 0.000 description 1
- 230000003913 calcium metabolism Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- MPCMQXRREZMSPJ-UHFFFAOYSA-L calcium;2-hydroxybutanedioate;2-hydroxypropane-1,2,3-tricarboxylic acid;pentahydrate Chemical compound O.O.O.O.O.[Ca+2].[O-]C(=O)C(O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O MPCMQXRREZMSPJ-UHFFFAOYSA-L 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000013409 condiments Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 150000002500 ions Chemical group 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a calcium lactate granule composition suitable for calcium supplement for young children and a preparation method thereof. The composition comprises the following components calculated in parts by weight: 50-90 parts of calcium lactate, 0.5-1 part of zinc citrate, 0.3-1 part of ferrous lactate, 5-10 parts of casein phosphopeptide, 350-400 parts of glucose, 20-40 parts of fructo-oligosaccharide, 5-10 parts of L-malic acid and 10-30 parts of edible traditional Chinese medicinal material granules for strengthening spleen and replenishing qi. The preparation method is as follows: A, edible traditional Chinese medicinal material granule preparation, and B, raw material mixing and sterilization; compared with the prior art, the composition makes an effective combination of calcium supplements and traditional Chinese medicines to achieve the combination of Chinese and western, as well as the combination of food and medicine; the casein phosphopeptide promotes the absorption of calcium, iron and zinc; the zinc citrate promotes digestion and absorption; the L-malic acid promotes absorption and metabolism, ingredients of the edible traditional Chinese medicinal material granules for strengthening spleen and replenishing qi promote the digestion and absorption; and citric acid radical, malic acid, lactate radical and calcium ion are easy to form metastable calcium salt to inhibit the formation of insoluble calcium, so that the composition can better promote the absorption of calcium, iron and zinc for young children to achieve the effect of 1 + 1 > 2.
Description
Technical field
The present invention relates to field of health care food, particularly relate to the granular calcium lactate composition that a kind of child of being applicable to replenishes the calcium.
Background technology
Containing several mineral materials in human body, wherein calcium is the one that content is maximum.Why comparatively firmly, mainly the inside is containing more calcareous relation for the bone of people and tooth, and calcium is the main component forming bone and tooth.If child's calcium deficiency, dental growth growth can postpone, and some children's did not also teethe more than 2 years old, and bone also can deliquescing, serious formation rickets, O shape leg or X-shaped leg.In addition, in nerve conduction, muscular movement, blood clotting and metabolism etc., calcareous participation is all needed.
Calcium deficiency is global nutrition problem, the general calcium deficiency of Chinese, and solve calcium deficiency problem must set about from two aspects simultaneously, and one is the intake increasing calcium, and two is the absorption rate improving calcium.Child is in the important period of bone and dental growth growth, more than adult to the requirement of calcium.Therefore, child's supplement calcium will be given in time and suitably.But, although some father and mother focuses on replenishing the calcium to child, but child still has the performance of calcium deficiency, this is because they often only focus on the intake increasing calcium, do not improve the absorption rate of calcium, and calcium is just easily absorbed when only existing with ionic forms, in neutrality and weakly alkaline environment, easy and acid ion forms insoluble salt and runs off again, but the cereal in the diet of people is again containing a large amount of phytic acid, the contour phosphorus composition of phytic acid, they are easily combined with calcium and generate calcium phosphate precipitation under the environment of PH7 ~ 8, small intestine lower end, this just causes supplementary calcium major part to be absorbed by the body.
Domestic market there is more than 200 kind of calcium tonic, mostly be conceived to the intake increasing calcium, and improve the absorption of calcium, utilization rate product category little, in recent years, some nutraceutical and health food manufacturer also strengthen vitamin D while it produces strengthening calcium, object improves the absorption rate of calcium, and this is the only way up to the present solving calcium uptake utilization rate and adopt.But, although the growth of vitamin D to bone has very important effect, but vitamin D excess intake can cause certain harm to kidney and bone, being grown up, it is poisoning with regard to easily causing to take in 25 μ g vitamin Ds long-term every day, therefore, developmental youngsters and children, must under the guidance of doctor appropriate vitamin D, this just to improving the absorption of calcium, there is very large restriction in utilization rate.
In addition, iron and zinc are the mineral matters that Chinese the most easily lack except calcium, if replenish the calcium merely, excessively, also can affect to the absorption of iron and zinc, and this is very disadvantageous to growing of child.
Summary of the invention
Technical problem to be solved by this invention is to provide and a kind ofly effectively can overcomes general calcium tonic and be better applicable to the potential for adverse effects of iron and zinc-iron alloy solution, calcium absorption better effects if, alimentary health-care function the granular calcium lactate composition that child replenishes the calcium.
The technical scheme that the present invention solves the problems of the technologies described above is as follows:
The granular calcium lactate composition that a kind of child of being applicable to replenishes the calcium, with parts by weight, it comprises following component: the edible Chinese medicine granule of 50-90 part calcium lactate, 0.5-1 part zinc citrate, 0.3-1 part ferrous lactate, 5-10 part CPP, 350-400 part glucose, 20-40 part FOS, 5-10 part L MALIC ACID, the strengthening the spleen and replenishing qi of 10-30 part.
Compared with prior art, the invention has the beneficial effects as follows:
Together with traditional calcium tonic is effectively combined into traditional Chinese medicine by the granular calcium lactate composition in the present invention, realize Chinese and Western to combine, food medicine combines, not only comprise calcium, iron, the trace elements such as zinc, also comprise and promote calcium simultaneously, iron, the CPP of zinc-iron alloy solution, promote the zinc citrate of human consumption's absorption function, promote the L MALIC ACID of food Absorption And Metabolism in human body, improve the edible Chinese medicine composition of the strengthening the spleen and replenishing qi of human consumption's absorption function, and citrate, malic acid, lactate and calcium ion easily form metastable refrigerated calcium citrate malate or citrated milk acid calcium salt, both the generation that insoluble calcium precipitates had been suppressed, do not affect again the absorption of calcium ion, the composition that these kinds differ widely complements each other, better can promote that child is to calcium under synergy, iron, the absorption of zinc, reach the effect of 1+1 > 2.
On the basis of technique scheme, the present invention can also do following improvement.
As a kind of preferred embodiment of the present invention, described calcium lactate is with rice gelatinization saccharified liquid or corn flour double-enzyme hydrolysis liquid for fermentation raw material, to obtain after lactate buffer solution, again with calcium carbonate neutralization, finally solution evaporation being obtained by fermentation.
The beneficial effect of above-mentioned preferred version is adopted to be: calcium lactate is that fermenting raw materials obtains, even if excess is taken also can not produce any toxic and side effect to human body with food.
As another kind of preferred embodiment of the present invention, described CPP take bovine casein as raw material, made by refining after pancreatin or trypsin hydrolysis, purifying.
The beneficial effect of above-mentioned preferred version is adopted to be: CPP derives from milk protein, even if excess is taken also can not produce any toxic and side effect to human body.
As another kind of preferred embodiment of the present invention, described L MALIC ACID is with the slurries of immature fruit for raw material, refining after being extracted by extraction, purifying and making.
The beneficial effect of above-mentioned preferred version is adopted to be: L MALIC ACID derives from natural fruits, even if excess is taken also can not produce any toxic and side effect to human body.
As another kind of preferred embodiment of the present invention, described immature fruit is that one or more are selected from the immature fruit in hawthorn, grape, peach or apple.
Adopt the beneficial effect of above-mentioned preferred version to be: L MALIC ACID is almost present in all fruits, with in pomaceous fruit at most, from hawthorn, grape, peach or apple, extract L MALIC ACID efficiency higher.
As another kind of preferred embodiment of the present invention, the Chinese medicine that described edible Chinese medicine granule is selected from ginseng, Radix Glycyrrhizae, orange peel, Chinese yam, dark plum, lotus seeds, Buddha's hand, the membrane of a chicken's gizzard, fructus amomi, coix seed, hawthorn or Poria cocos by one or more is refining to be formed
Adopt the beneficial effect of above-mentioned preferred version to be: above-mentioned Chinese medicine is food and medicament dual-purpose, has no side effect, and has the drug effect of strengthening the spleen and replenishing qi, can improve human consumption's function, promote calcium absorption.
Be applicable to a preparation method for the granular calcium lactate composition that child replenishes the calcium as above, it comprises the following steps:
A, prepare edible Chinese medicine granule
First get the edible Chinese medicine of invigorating the spleen tonifying Qi, chopping or pulverizing are placed on and decoct in container, then add water boil, then filter and obtain fried liquid, finally by concentrated, dry, namely obtain described edible Chinese medicine granule;
The mixing of B, raw material and sterilization
With parts by weight, get the edible Chinese medicine granule described in 10-30 part, and mix with 50-90 part calcium lactate, 0.5-1 part zinc citrate, 0.3-1 part ferrous lactate, 5-10 part CPP, 350-400 part glucose, 20-40 part FOS, 5-10 part L MALIC ACID, after fully mixing, sterilization, packaging, is applicable to the granular calcium lactate composition that child replenishes the calcium described in namely obtaining.
Compared with prior art, the invention has the beneficial effects as follows:
The method preparing granular calcium lactate composition in the present invention is simple to operate, by calcium, iron, the trace elements such as zinc, calcium can be promoted simultaneously, iron, the CPP of zinc-iron alloy solution, the zinc citrate of human consumption's absorption function can be promoted, promote the L MALIC ACID of food Absorption And Metabolism in human body, the edible Chinese medicine composition that can improve the strengthening the spleen and replenishing qi of human consumption's absorption function is effectively combined into together, realize Chinese and Western to combine, food medicine combines, the composition that these kinds differ widely complements each other, better can promote that child is to calcium under synergy, iron, the absorption of zinc, reach the effect of 1+1 > 2.
As another kind of preferred embodiment of the present invention, in step, described fried liquid adopts centrifugal thin-film to be concentrated to 20%-40%.
The beneficial effect of above-mentioned preferred version is adopted to be: carrying out drying after being concentrated to this concentration again can be more prone to, and raises the efficiency.
As another kind of preferred embodiment of the present invention, in step, adopt spraying dry, EAT is 110-160 DEG C, and leaving air temp is 70-90 DEG C.
The beneficial effect of above-mentioned preferred version is adopted to be: not only drying effect is good, efficiency is high, and can not destroy the activity of edible Chinese medicine granule.
As another kind of preferred embodiment of the present invention, in stepb, described sterilization is specially sterilization 10-15s under 90-95 DEG C of condition.
The beneficial effect of above-mentioned preferred version is adopted to be: not only bactericidal effect is good, and can not destroy the activity of particulate composition.
Below the present invention is described in further details.
The granular calcium lactate composition that a kind of child of being applicable to replenishes the calcium, with parts by weight, it comprises following component: the edible Chinese medicine granule of 50-90 part calcium lactate, 0.5-1 part zinc citrate, 0.3-1 part ferrous lactate, 5-10 part CPP, 350-400 part glucose, 20-40 part FOS, 5-10 part L MALIC ACID, the strengthening the spleen and replenishing qi of 10-30 part;
Wherein, described calcium lactate is with rice gelatinization saccharified liquid or corn flour double-enzyme hydrolysis liquid for fermentation raw material, to obtain after lactate buffer solution, again with calcium carbonate neutralization, finally solution evaporation being obtained by fermentation;
Described CPP take bovine casein as raw material, made by refining after pancreatin or trypsin hydrolysis, purifying;
Described L MALIC ACID is selected from the slurries of the immature fruit in hawthorn, grape, peach or apple for raw material with one or more, refining after being extracted by extraction, purifying and making;
The Chinese medicine that described edible Chinese medicine granule is selected from ginseng, Radix Glycyrrhizae, orange peel, Chinese yam, dark plum, lotus seeds, Buddha's hand, the membrane of a chicken's gizzard, fructus amomi, coix seed, hawthorn or Poria cocos by one or more is refining to be formed.
Be applicable to a preparation method for the granular calcium lactate composition that child replenishes the calcium as above, it comprises the following steps:
A, prepare edible Chinese medicine granule
First get the edible Chinese medicine of invigorating the spleen tonifying Qi, chopping or pulverizing are placed on and decoct in container, add water boil again, then filter and obtain fried liquid, centrifugal thin-film is adopted to be concentrated to 20%-40% described fried liquid again, finally EAT be 110-160 DEG C, leaving air temp carries out spraying dry under being the condition of 70-90 DEG C, namely obtains described edible Chinese medicine granule;
The mixing of B, raw material and sterilization
With parts by weight, get the edible Chinese medicine granule described in 10-30 part, and mix with 50-90 part calcium lactate, 0.5-1 part zinc citrate, 0.3-1 part ferrous lactate, 5-10 part CPP, 350-400 part glucose, 20-40 part FOS, 5-10 part L MALIC ACID, after fully mixing, sterilization 10-15s under 90-95 DEG C of condition, packaging, is applicable to the granular calcium lactate composition that child replenishes the calcium described in namely obtaining.
In the present invention, calcium lactate is as food calcium hardening agent, and calcium absorptivity is very high, and assimilation effect is better than inorganic calcium, calcium gluconae; Ferrous lactate is as food ferrous-fortifier, and assimilation effect is better than inorganic iron; And zinc citrate is as organic zinc tonic, little to gastric irritation, zinc content is high, and participates in tricarboxylic acid cycle in human body, strengthen human consumption's absorption function, and zinc citrate is the unique a kind of Zn complex existed in human mother's milk, be easier to absorb than the zinc in milk, stable performance, also there is anti-adhesive functional, be specially adapted to manufacture powdery mixed food, the while of iron, zinc during famine, select zinc citrate can avoid playing antagonism with iron.
In the present invention, CPP can promote that small intestine, bone, tooth are to the absorption of calcium, derive from milk protein, even if excess is taken also can not produce any toxic and side effect to human body, be can be combined with calcium under neutral and weakly alkaline environment to the absorption main manifestations of calcium, suppress the generation of infusible precipitate, avoid the loss of calcium, finally the Passive intake because of the raising of free calcium concentration; It can also improve the absorption rate of iron and zinc simultaneously, thus effectively overcomes the potential for adverse effects of general calcium tonic to iron, zinc-iron alloy solution, and this point is the characteristic that other calcium tonic any does not possess; In addition, it has consoluet characteristic within the scope of very wide pH, can withstand high temperatures process, has good stability.
In the present invention, FOS is as novel sweetener, both product taste can be improved, reduce food calorific value, the effect of mineral matters such as promoting calcium, magnesium, iron and absorption of trace elements can be reached again, and can promote naturally to synthesize category-B B B-complex in body, have and support brain, nervous system activity, promote the effect that digestion and energy generate.
In the present invention, L MALIC ACID is the important composition of fruit juice, tart flavour is stronger than citric acid by 20%, but taste is soft, tool peat-reek, do not damage oral cavity and tooth, not only there is the effect of acid condiment, antistaling agent, food Absorption And Metabolism in human body can also be promoted, and the acid condition of malic acid advantageously in human body to calcareous absorption; In addition, in medicine, generally add L MALIC ACID can increase its stability, promote that medicine is in the absorption of human body, diffusion.
The edible Chinese medicine granule of strengthening the spleen and replenishing qi in the present invention is that after adopting the edible Chinese medicine of strengthening the spleen and replenishing qi to decoct, concentrated refining forms, joined in calcium tonic, drug effect can not only be ensured, improve human consumption's function, promote the nutrient absorption such as calcareous, and then strengthening bone, and take convenient.
The edible Chinese medicine composition of strengthening the spleen and replenishing qi in the present invention is combined with CPP, can greatly promote the effect that the mineral matter elements such as calcium, zinc, iron absorb to reach the effect of 1+1 > 2; The edible Chinese medicine composition of strengthening the spleen and replenishing qi is combined with FOS, greatly can promote the effect of the mineral matters such as calcium, magnesium, iron and absorption of trace elements, reach the effect of 1+1 > 2; The edible Chinese medicine composition of strengthening the spleen and replenishing qi is combined with L MALIC ACID, greatly can promote food Absorption And Metabolism in human body, especially strengthens the effect absorbed mineral matter elements such as calcium, zinc, iron, reaches the effect of 1+1 > 2; The edible Chinese medicine composition of strengthening the spleen and replenishing qi is combined with zinc citrate, can greatly strengthen human consumption's absorption function, especially strengthens the effect absorbed mineral matter elements such as calcium, zinc, iron, reaches the effect of 1+1 > 2.
Detailed description of the invention
Be described principle of the present invention and feature below, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
The granular calcium lactate composition that a kind of child of being applicable to replenishes the calcium, with parts by weight, it comprises following component: the edible Chinese medicine granule of 50 parts of calcium lactates, 0.5 part of zinc citrate, 0.3 part of ferrous lactate, 5 parts of CPPs, 350 parts of glucose, 20 parts of FOSs, 5 parts of L MALIC ACIDs, 10 parts of strengthening the spleen and replenishing qi;
Wherein, described calcium lactate is with rice gelatinization saccharified liquid or corn flour double-enzyme hydrolysis liquid for fermentation raw material, to obtain after lactate buffer solution, again with calcium carbonate neutralization, finally solution evaporation being obtained by fermentation;
Described CPP take bovine casein as raw material, made by refining after pancreatin or trypsin hydrolysis, purifying;
Described L MALIC ACID is selected from the slurries of the immature fruit in hawthorn, grape, peach or apple for raw material with one or more, refining after being extracted by extraction, purifying and making;
The Chinese medicine that described edible Chinese medicine granule is selected from ginseng, Radix Glycyrrhizae, orange peel, Chinese yam, dark plum, lotus seeds, Buddha's hand, the membrane of a chicken's gizzard, fructus amomi, coix seed, hawthorn or Poria cocos by one or more is refining to be formed.
Be applicable to a preparation method for the granular calcium lactate composition that child replenishes the calcium as above, it comprises the following steps:
A, prepare edible Chinese medicine granule
First get the edible Chinese medicine of invigorating the spleen tonifying Qi, chopping or pulverizing are placed on and decoct in container, add water boil again, then filter and obtain fried liquid, centrifugal thin-film is adopted to be concentrated to 20% described fried liquid again, finally EAT be 110 DEG C, leaving air temp carries out spraying dry under being the condition of 70 DEG C, namely obtains described edible Chinese medicine granule;
The mixing of B, raw material and sterilization
With parts by weight, get the edible Chinese medicine granule described in 10 parts, and mix with 50 parts of calcium lactates, 0.5 part of zinc citrate, 0.3 part of ferrous lactate, 5 parts of CPPs, 350 parts of glucose, 20 parts of FOSs, 5 parts of L MALIC ACIDs, after fully mixing, sterilization 15s under 90 DEG C of conditions, packaging, is applicable to the granular calcium lactate composition that child replenishes the calcium described in namely obtaining.
Embodiment 2
The granular calcium lactate composition that a kind of child of being applicable to replenishes the calcium, with parts by weight, it comprises following component: the edible Chinese medicine granule of 70 parts of calcium lactates, 0.7 part of zinc citrate, 0.6 part of ferrous lactate, 7.5 parts of CPPs, 400 parts of glucose, 40 parts of FOSs, 7.5 parts of L MALIC ACIDs, 20 parts of strengthening the spleen and replenishing qi;
Wherein, described calcium lactate is with rice gelatinization saccharified liquid or corn flour double-enzyme hydrolysis liquid for fermentation raw material, to obtain after lactate buffer solution, again with calcium carbonate neutralization, finally solution evaporation being obtained by fermentation;
Described CPP take bovine casein as raw material, made by refining after pancreatin or trypsin hydrolysis, purifying;
Described L MALIC ACID is selected from the slurries of the immature fruit in hawthorn, grape, peach or apple for raw material with one or more, refining after being extracted by extraction, purifying and making;
The Chinese medicine that described edible Chinese medicine granule is selected from ginseng, Radix Glycyrrhizae, orange peel, Chinese yam, dark plum, lotus seeds, Buddha's hand, the membrane of a chicken's gizzard, fructus amomi, coix seed, hawthorn or Poria cocos by one or more is refining to be formed.
Be applicable to a preparation method for the granular calcium lactate composition that child replenishes the calcium as above, it comprises the following steps:
A, prepare edible Chinese medicine granule
First get the edible Chinese medicine of invigorating the spleen tonifying Qi, chopping or pulverizing are placed on and decoct in container, add water boil again, then filter and obtain fried liquid, centrifugal thin-film is adopted to be concentrated to 30% described fried liquid again, finally EAT be 135 DEG C, leaving air temp carries out spraying dry under being the condition of 80 DEG C, namely obtains described edible Chinese medicine granule;
The mixing of B, raw material and sterilization
With parts by weight, get the edible Chinese medicine granule described in 20 parts, and mix with 70 parts of calcium lactates, 0.7 part of zinc citrate, 0.6 part of ferrous lactate, 7.5 parts of CPPs, 400 parts of glucose, 40 parts of FOSs, 7.5 parts of L MALIC ACIDs, after fully mixing, sterilization 13s under 92 DEG C of conditions, packaging, is applicable to the granular calcium lactate composition that child replenishes the calcium described in namely obtaining.
Embodiment 3
The granular calcium lactate composition that a kind of child of being applicable to replenishes the calcium, with parts by weight, it comprises following component: the edible Chinese medicine granule of 90 parts of calcium lactates, 1 part of zinc citrate, 1 part of ferrous lactate, 10 parts of CPPs, 375 parts of glucose, 30 parts of FOSs, 10 parts of L MALIC ACIDs, 30 parts of strengthening the spleen and replenishing qi;
Wherein, described calcium lactate is with rice gelatinization saccharified liquid or corn flour double-enzyme hydrolysis liquid for fermentation raw material, to obtain after lactate buffer solution, again with calcium carbonate neutralization, finally solution evaporation being obtained by fermentation;
Described CPP take bovine casein as raw material, made by refining after pancreatin or trypsin hydrolysis, purifying;
Described L MALIC ACID is selected from the slurries of the immature fruit in hawthorn, grape, peach or apple for raw material with one or more, refining after being extracted by extraction, purifying and making;
The Chinese medicine that described edible Chinese medicine granule is selected from ginseng, Radix Glycyrrhizae, orange peel, Chinese yam, dark plum, lotus seeds, Buddha's hand, the membrane of a chicken's gizzard, fructus amomi, coix seed, hawthorn or Poria cocos by one or more is refining to be formed.
Be applicable to a preparation method for the granular calcium lactate composition that child replenishes the calcium as above, it comprises the following steps:
A, prepare edible Chinese medicine granule
First get the edible Chinese medicine of invigorating the spleen tonifying Qi, chopping or pulverizing are placed on and decoct in container, add water boil again, then filter and obtain fried liquid, centrifugal thin-film is adopted to be concentrated to 40% described fried liquid again, finally EAT be 160 DEG C, leaving air temp carries out spraying dry under being the condition of 90 DEG C, namely obtains described edible Chinese medicine granule;
The mixing of B, raw material and sterilization
With parts by weight, get the edible Chinese medicine granule described in 30 parts, and mix with 90 parts of calcium lactates, 1 part of zinc citrate, 1 part of ferrous lactate, 10 parts of CPPs, 375 parts of glucose, 30 parts of FOSs, 10 parts of L MALIC ACIDs, after fully mixing, sterilization 10s under 95 DEG C of conditions, packaging, is applicable to the granular calcium lactate composition that child replenishes the calcium described in namely obtaining.
Embodiment 4
Choose the clean rat 30 in 4 week age, body weight 80-90g, is divided into three groups at random, often organizes each 10; 1 group of rat is control group, feeds basal feed, and 2 groups of rats feed the basal feed being added with common lactic acid calcium powder, and 3 groups of rats feed the basal feed being added with granular calcium lactate composition group of the present invention; Measure basal feed by EDTA method, be added with the basal feed of common lactic acid calcium powder, be added with the calcium content of the basal feed of granular calcium lactate composition group of the present invention simultaneously, result is respectively 0.91mg/g, 8.02mg/g, 8.33mg/g.
After feeding 2 weeks, carry out the metabolic test of 3 days by a definite date, accurate recording Feed consumption and excrement, urinary output, and mixing keeps sample respectively, with the calcium content that EDTA method determination test rat voids excreta, and calcium Retention=(feed calcium intake-discharge calcium amount)/feed calcium intake × 100%, every test data mean value is as shown in the table:
As seen from the experiment, the calcium content of 1 group of (control group) ight soil, urine is zero, calcium metabolism of rat completely not contained by basal feed is described, entirely by rat resorption, this also demonstrates and feeds rat with the basal feed of joining is comparatively suitable, because if the calcium contained by basal feed is enough for metabolism of rat, the calcium lactate added so cannot by rat resorption, and experiment also cannot go on.
Result of the test also shows, the ight soil of 2 groups and 3 groups, urine calcium content is greatly improved compared with 1 group (control group), and the ight soil of 2 groups, the calcium content of urine is greater than 3 groups, the calcium amount retained that can calculate 3 groups is thus greater than 2 groups, the calcium Retention finally calculated also is 3 groups and is greater than 2 groups, because the calcium retention ratio in animal body often reflects the metabolic adsorption rate of animal to calcium, therefore known, rat will much larger than their absorptivities to calcium in common granular calcium lactate to the absorptivity of calcium in granular calcium lactate composition of the present invention, and calcium lactate is as food calcium hardening agent, calcium absorptivity is inherently very high, assimilation effect is better than inorganic calcium, other food calcium hardening agent such as calcium gluconae, therefore, be applicable to the granular calcium lactate composition that child replenishes the calcium in the present invention and obviously can improve the absorptivity of human body to calcium more significantly.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the granular calcium lactate composition being applicable to child and replenishing the calcium, it is characterized in that, with parts by weight, it comprises following component: the edible Chinese medicine granule of 50-90 part calcium lactate, 0.5-1 part zinc citrate, 0.3-1 part ferrous lactate, 5-10 part CPP, 350-400 part glucose, 20-40 part FOS, 5-10 part L MALIC ACID, the strengthening the spleen and replenishing qi of 10-30 part.
2. the child of the being applicable to according to claim 1 granular calcium lactate composition of replenishing the calcium, it is characterized in that, described calcium lactate is with rice gelatinization saccharified liquid or corn flour double-enzyme hydrolysis liquid for fermentation raw material, to obtain after lactate buffer solution, again with calcium carbonate neutralization, finally solution evaporation being obtained by fermentation.
3. the child of the being applicable to according to claim 1 granular calcium lactate composition of replenishing the calcium, it is characterized in that, described CPP take bovine casein as raw material, made by refining after pancreatin or trypsin hydrolysis, purifying.
4. the child of the being applicable to according to claim 1 granular calcium lactate composition of replenishing the calcium, it is characterized in that, described L MALIC ACID is with the slurries of immature fruit for raw material, refining after being extracted by extraction, purifying and making.
5. the child of the being applicable to according to claim 4 granular calcium lactate composition of replenishing the calcium, it is characterized in that, described immature fruit is that one or more are selected from the immature fruit in hawthorn, grape, peach or apple.
6. the child of the being applicable to according to claim 1 granular calcium lactate composition of replenishing the calcium, it is characterized in that, the Chinese medicine that described edible Chinese medicine granule is selected from ginseng, Radix Glycyrrhizae, orange peel, Chinese yam, dark plum, lotus seeds, Buddha's hand, the membrane of a chicken's gizzard, fructus amomi, coix seed, hawthorn or Poria cocos by one or more is refining to be formed.
7. the preparation method being applicable to the granular calcium lactate composition that child replenishes the calcium according to any one of claim 1-6, it is characterized in that, it comprises the following steps:
A, prepare edible Chinese medicine granule
First get the edible Chinese medicine of invigorating the spleen tonifying Qi, chopping or pulverizing are placed on and decoct in container, then add water boil, then filter and obtain fried liquid, finally by concentrated, dry, namely obtain described edible Chinese medicine granule;
The mixing of B, raw material and sterilization
With parts by weight, get the edible Chinese medicine granule described in 10-30 part, and mix with 50-90 part calcium lactate, 0.5-1 part zinc citrate, 0.3-1 part ferrous lactate, 5-10 part CPP, 350-400 part glucose, 20-40 part FOS, 5-10 part L MALIC ACID, after fully mixing, sterilization, packaging, is applicable to the granular calcium lactate composition that child replenishes the calcium described in namely obtaining.
8. the preparation method of granular calcium lactate composition that replenishes the calcium of the child of being applicable to according to claim 7, it is characterized in that, in step, described fried liquid adopts centrifugal thin-film to be concentrated to 20%-40%.
9. the preparation method of granular calcium lactate composition that replenishes the calcium of the child of being applicable to according to claim 7, it is characterized in that, in step, adopt spraying dry, EAT is 110-160 DEG C, and leaving air temp is 70-90 DEG C.
10. the preparation method of granular calcium lactate composition that replenishes the calcium of the child of being applicable to according to claim 7, it is characterized in that, in stepb, described sterilization is specially sterilization 10-15s under 90-95 DEG C of condition.
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| CN110101086A (en) * | 2019-04-30 | 2019-08-09 | 彤博士健康产业河北有限公司 | A kind of composition and preparation method thereof of replenishing the calcium promoting calcium uptake |
| CN110679816A (en) * | 2019-10-29 | 2020-01-14 | 徐州三源医药科技集团有限公司 | Solid beverage capable of enhancing immunity and preparation method thereof |
| CN112754019A (en) * | 2020-12-23 | 2021-05-07 | 河南九天生物科技有限公司 | Composition containing 25 hydroxyl d3 and calcium gluconate and preparation method thereof |
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