CN106417619A - Milk calcium powder for promoting skeleton growth and enhancing immunity - Google Patents
Milk calcium powder for promoting skeleton growth and enhancing immunity Download PDFInfo
- Publication number
- CN106417619A CN106417619A CN201610802756.7A CN201610802756A CN106417619A CN 106417619 A CN106417619 A CN 106417619A CN 201610802756 A CN201610802756 A CN 201610802756A CN 106417619 A CN106417619 A CN 106417619A
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- Prior art keywords
- calcium
- powder
- zinc
- milk
- magnesium
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
Abstract
The invention discloses milk calcium powder for promoting skeleton growth and enhancing immunity. The milk calcium powder is prepared from the following ingredients in parts by weight: 0.1-35 parts of milk calcium, 0.01-4.76 parts of calcium L-aspartate, 0.985-2.584 parts of tricalcium phosphate, 0.46-0.73 part of magnesium carbonate, 0.043-0.128 part of zinc gluconate, 0.1-0.8 part of casein phosphopeptides, 0.11-0.14 part of taurine and 10-70 parts of whole milk powder. The milk calcium powder can effectively increase the absorption and utilization rate of calcium, phosphorus, magnesium and zinc, so that the purposes of promoting skeleton growth and enhancing immunity are achieved.
Description
Technical field
The invention belongs to functional food technical field, particularly to a kind of breast promoting bone growth and enhance immunity
Calcium powder.
Background technology
Calcium is the main component constituting skeleton and tooth, and in health adult's body, calcium total amount is about 1000～1300 grams,
About percentage of liveweight 1.5%～2.0%.Wherein 99% calcium is present in skeleton and tooth with bone mineral form, and bone is doped calcium
Main portions, so there is the title in " calcium storehouse ".Bone calcium is mainly deposited with two kinds of forms of apatite of non-crystal calcium hydrogen phosphate and crystal
?.Child is in the important period that skeleton and dental growth are developed, if calcium deficiency will lead to, lower limb is soft, cramp, breastbone pain,
" X " type lower limb, " O " type lower limb, pigeon chest；Teething is late, tooth arrangement is sparse, irregular, tight, decayed tooth, tooth are darkly pointed or saw
Profile of tooth, hypoplasia of tooth；Hypoevolutism, height deficiency etc..
Phosphorus is present in all cells of human body, is the necessary material maintaining skeleton and tooth, almost participate in all physiologically
Chemical reaction.The main component apatite of skeleton and tooth is made up of phosphorus and calcium.People to adult when although skeleton
Through stopping growing, but calcium therein and phosphorus are still being constantly updated, and about update 20% every year that is to say, that just updated one every 5 years
Time.The ability of self-healing but tooth is after growing, will be lost.If calcium deficiency during child's long teeth, tooth is easy for damaging
Bad.Because lacking calcium and phosphorus, often there are osteomalacia or ricketss in some children.
Magnesium is a kind of participation organism normal activities and the requisite element of metabolic processes.Adult normal's body
Body total content of magnesium about 25g, wherein 60%～65% is present in bone, tooth, and in skeleton, magnesium is only second to calcium, phosphorus, is osteocyte structure
With element necessary to function, to promoting bone growing and osteanagenesis, skeleton and the intensity of tooth and density is maintained to have important work
With.In the metabolism of calcium, vitamin C, phosphorus, sodium, potassium etc., magnesium is necessary material, and therefore magnesium exhausts the institute to bone metabolism for the meeting
There is the stage to produce adverse effect, lead to skeleton to stop growing, broken bone and Osteoblastic activity minimizing, osteopenia and bone fragility increase
Plus；Affect on produced by calcium metabolism because magnesium is not enough, also become the risk factor of osteoporosis.
Zinc is one of necessary trace element of 14 kinds of human bodies, and content is only second to ferrum.Wherein zinc has 50% to be present in muscle,
20% is present in skeleton, additionally, also containing 20% in skin, fingernail, hair, remaining zinc be present in liver, kidney, brain, lung and
In heart tissue, zinc is Osteoblastic activity, collage synthesis and alkali phosphatase are required, therefore the growth promoter of zinc and human body, new
Old metabolism has the relation of interwoveness, and the deficiency of zinc can weaken bone formation and absorption.The synthesis of zinc participation growth hormone is simultaneously right
Growth hormone works, and accelerate cell division speed, so that the metabolism of cell is maintained in higher level, thus accelerating
Virgin and adolescent growth is developed.The disease of human body 90% is relevant with immunity, and sufficient zinc can lift thymus, T lymphocyte is attacked
Hit, annihilate the immunologic functions such as sex pheromone, enhance immunity, thus reducing the possibility that child infects multiple epidemic diseases.
Calcium, phosphorus, magnesium, zinc are the important components of human body, promote the strong of skeleton formation, growth, maintenance skeleton and tooth
Degree and density, lack calcium, phosphorus, magnesium, zinc during upgrowth and development of children, can cause growth retardation, osteoporosises, height not
The generation of the condition of illness such as foot, immunity degradation.
And the nutrient generally existing problems with of supplementary calcium traditional in the market, phosphorus, magnesium, zinc：1. the absorption of calcium
Disturbed by phytic acid, oxalates etc., simultaneously as absorption of human body calcium is mainly in small intestinal bottom, and small intestinal bottom is weakly alkaline,
Calcium easily produces precipitation, and impact absorbs；2. magnesium, zinc absorption are low；3. tricalcium phosphate and calcium hydrogen phosphate as phosphorus source are less soluble
Enter water, be difficult to be absorbed, excreted with Precipitation；4. magnesium, zinc can affect absorbing of calcium.
Content of the invention
The present invention is directed to the deficiencies in the prior art, provides a kind of calcium that can simultaneously supplement needed by human body, phosphorus, magnesium, zinc, promotes
The milk calcium powder of bone growth and enhance immunity.
The technical solution used in the present invention is：
A kind of milk calcium powder promoting bone growth and enhance immunity, by weight meter include following dispensing：
A kind of described promotion bone growth and the milk calcium powder of enhance immunity, count by weight and also include Fructus Musae powder 5-
50 parts.
A kind of described promotion bone growth and the milk calcium powder of enhance immunity, count by weight and also include glucose
10-60 part.
A kind of described promotion bone growth and the milk calcium powder of enhance immunity, count by weight and also include vitamin D3
Dry powder 0.0004-0.0008 part.
A kind of preparation method of the described milk calcium powder promoting bone growth and enhance immunity, each dispensing is routinely made
Agent method is prepared into powder, accurately weighs each dispensing respectively first, after being then sufficiently mixed uniformly, carries out subpackage.
The invention has the advantages that：
Milk calcium in the milk calcium powder of a kind of present invention promotion bone growth and enhance immunity and ASPARTIC ACID calcium carry
For calcium source, tricalcium phosphate provides phosphorus source, and magnesium carbonate provides magnesium source, and zinc gluconate provides zinc source, add phosphopeptide caseinate with
Avoid calcium, magnesium, zinc mutually exclusive, thus improving calcium, magnesium, zinc-iron alloy solution utilization rate, vitamin D3Dry powder is used for just maintaining phosphorus
Often function, calcium phosphorus magnesium zinc forms the gold partner promoting bone growth and enhance immunity, and taurine has enhance immunity
Synergism.
Milk calcium is the pure natural active high lactoprotein calcium directly extracting from milk.The milk mineral being rich in milk calcium
Matter is the natural origin extracting from milk, and the advantage of these compositions not only provides the trophic component of balance moreover it is possible to promote
The absorbing of calcium, such as phosphorus, magnesium, Lactose and protein etc..The calcium-phosphorus ratio 2 of science in milk calcium:1, most useful for the absorption profit of human body
With.Due to containing abundant Lactose and albumen in Lac Bovis seu Bubali, therefore its absorbance is much higher than other common calcium, and milk calcium absorbance is up to
62%～70%, it is 2.5 times of Calcium Carbonate and calcium gluconate, is 1.75 times of calcium lactate, be 5.5 times of shellfish calcium.Edible
It is not result in flatulence, edema, constipation, so milk calcium is one of best source of replenishing the calcium at present after milk calcium.
ASPARTIC ACID calcium is the chelating type structure by two aminoacid and a calcium binding, approximately natural two
Peptide protein calcium, is a kind of short chain albumen calcium molecule, and absorbing does not need vitamin D3Participate in, easily pass through enterocyte, directly
By people's intestinal absorption, unreachable for general calcium bulk formulation.In addition, chelating type Stability Analysis of Structures, it is difficult in human body intestinal canal
Be combined with the material such as the oxalic acid in food and plant acid and be lost, be seven times of its hetero-organization simultaneously to the affinity of osseous tissue,
Calculi in vivo disease will not therefore be caused, substantially increase the absorbance to calcium for the human body, absorbance is up to 90%-100%, is current
The higher calcium preparation of market coideal, safe and reliable bioavailability.
The magnesium content of magnesium carbonate is higher than the magnesium content of magnesium sulfate, magnesium chloride, magnesium hydrogen phosphate and magnesium gluconate although carbonic acid
The magnesium content of magnesium is not as good as magnesium oxide, but the aerial stability of magnesium carbonate is better than magnesium oxide, and cost is much lower.
Zinc gluconate has the advantage that as zinc source：1. organic zinc source, good stability, bioavailability is high, easily by
Body absorbs, and there are some researches show：Zinc gluconate reaches absorption peak soon in animal body, remains highly concentrated in the tissue such as liver, kidney
Time of spending is long, is secondly zinc sulfate, zinc chloride and zinc acetate；2. weak acid and mild base salt is little to the stimulation of stomach compared with zinc sulfate；3. Fructus Vitis viniferae
Saccharic acid zinc is white or near-white powdery, free from extraneous odour, and in good taste, the mouthfeel of zinc citrate and zinc lactate is all not as good as gluconic acid
Zinc；4. it is most widely used in organic zinc source and moderate.
Phosphopeptide caseinate (CPP) is with bovine casein as raw material, has biological activity by what biotechnology was obtained
Polypeptide, even if excess take also will not to human body produce any toxic and side effects.When CPP makes an addition to food, there is low amounts efficient
Feature, and original local flavor and mouthfeel can be kept.The physiological function of phosphopeptide caseinate and mechanism：
1) structure of CPP is continuous three phosphoserines then two glutamic acid, this specific amino acid structure, energy
Enough attract phosphate anion and calcium ion, under caseic mediation, these phosphate anions and calcium ion do not crystallize formation
Precipitation, but inorganization mobbish flock together with casein micelles among.Casein micelles are very stable, even high-temperature heating,
Long-term preservation, also will not be disintegrated.Calcium ion therein and phosphate anion content to retain sovereignty over a part of the country in micelle although the common water of concentration ratio
The concentration forming precipitation in solution is high, but lives together peacefully.Enter belly in albumen, segment, the polypeptide of formation have been cut into by protease
Still offer stubborn resistance the attack further of protease, protects these calcium ions and phosphate anion until small intestinal bottom quilt
Absorb, thus solving the problems, such as tricalcium phosphate because being difficult to dissolve in water and Precipitation.
2) CPP has the characteristic being completely dissolved in the range of very wide pH, can tolerate high-temperature process, has good stablizing
Property, even if pH is in neutral in weakly alkaline environment in human body intestinal canal, CPP can be with mineral ions such as calcium, ferrum, magnesium, zinc, selenium
In conjunction with, protect it from being precipitated by aniones such as the phosphoric acid in meals, oxalic acid, phytic acid, strengthen the concentration of enteral dissolvable mine material,
Thus promoting to absorb, especially promote absorption and the utilization of calcium, the CPP being described as " mineral carrier " is currently the only rush
The bioactive peptide of calcium absorption.
3) under conditions of CPP presence, phosphate anion and calcium ion can be in one kind and be called " amorphous calcium phosphate "
State, whole product is also just called " phosphopeptide caseinate amorphous calcium phosphate " complex.This complex has arrived tooth
Combining closely on tooth thus depositing on tooth, the corrosion dissolution rate of apatite (major part of tooth) can be significantly reduced.
Taurine is a kind of non-protein amino acid of sulfur-bearing, is existed although it is not involved in albumen with free state in vivo
Matter synthesizes, but closely related with the metabolism of cystine, cysteine.The cysteine sulfurous acid carboxylic acid of human body synthesizing taurine
Activity is relatively low, relies primarily on the external taurine absorbing to meet body requirement.Taurine can promote pituitary hormone secretion, activation
Pancreatic function, thus improving the state of organism endocrine system, to organism metabolism with beneficial regulation, and has promotion organism
The enhancing of immunity and the effect of resisting fatigue.
Specific embodiment
A kind of milk calcium powder promoting bone growth and enhance immunity, by weight meter include following dispensing：
Described all raw materials are and meet corresponding national standard/industry standard and state's domestic discipline and family rules through strict the commercially available of screening
Fixed qualified products.
A kind of preparation method of the milk calcium powder promoting bone growth and enhance immunity, using conventional formulation method preparation
Become powder, its preparation technology is：Accurately weigh each dispensing respectively, be sufficiently mixed uniformly, subpackage.
A kind of milk calcium powder promoting bone growth and enhance immunity of embodiment 1
The commercially available qualified products meeting corresponding national standard/industry standard and national regulation of strict screening, obtain each
Raw material；
Accurately weigh milk calcium 12.7kg, ASPARTIC ACID calcium 1.76kg, tricalcium phosphate 1.584kg, magnesium carbonate respectively
0.63kg, zinc gluconate 0.1054kg, phosphopeptide caseinate 0.7kg, taurine 0.12kg, vitamin D3Dry powder
0.0006kg, Fructus Musae powder 7.4kg, glucose 35kg, whole milk powder 40kg；
Each raw material powder after precise is sufficiently mixed uniformly, subpackage.
In the present embodiment product milk calcium powder, calcium phosphorus magnesium zinc assay is as follows：
| Sequence number | Detection project | Unit | Testing result |
| 1 | Calcium | mg/kg | 3.92×104 |
| 2 | Phosphorus | mg/kg | 1.98×104 |
| 3 | Magnesium | mg/kg | 1.75×103 |
| 4 | Zinc | mg/kg | 147 |
Embodiment 2 contrast experiment
Select several widely used material combination that calcium, phosphorus, magnesium, zinc element are provided so as to calcium, phosphorus, magnesium, zinc
Content is consistent with the content of calcium in embodiment 1 milk calcium powder, phosphorus, magnesium, zinc, carries out contrast experiment.
1) bone density contrast experiment：
Laboratory animal：The ablactation rat of 4～5 week old, body weight 60-75g, male, totally 40.
At random laboratory animal is divided into 5 groups according to body weight, every group of 8 rats：
Matched group：Distilled water
I group：Formula and consumption using embodiment 1；
II group：Calcium Carbonate, magnesium sulfate, tricalcium phosphate, zinc gluconate, phosphopeptide caseinate, taurine, vitamin D3Dry
Powder, Fructus Musae powder, glucose, whole milk powder；
III group：Calcium lactate, magnesium sulfate, tricalcium phosphate, zinc gluconate, phosphopeptide caseinate, taurine, vitamin D3Dry
Powder, Fructus Musae powder, glucose, whole milk powder；
IV group：Calcium gluconate, magnesium sulfate, tricalcium phosphate, zinc gluconate, phosphopeptide caseinate, taurine, vitamin
D3Dry powder, Fructus Musae powder, glucose, whole milk powder.
Respectively I, II, III, IV group compositionss are configured to desired concn with distilled water for solvent, matched group, I, II, III,
IV group of rat oral gavage give respectively matched group, I, the compositionss of II, III, IV, groundwater increment is daily 2.33g compositionss/kg
Body weight, after tested 3 months of this method, animal subject is put to death, the bone density of measurement femur midpoint and femur distal end, and result is such as
Under：
Table 1 bone density comparative test result
As shown in Table 1：The femur midpoint of I group of rat and femur distal end bone density be above matched group, II group, III group and
IV group (P ＜ 0.05).
2) immunity contrast experiment (carbonic clearance test)
Laboratory animal：The mice of 4～5 week old, 18～22g, male, totally 50.
At random laboratory animal is divided into 5 groups according to body weight, every group of 10 mices：
Matched group：Distilled water
I group：Formula and consumption using embodiment 1；
II group：Calcium Carbonate, magnesium sulfate, tricalcium phosphate, zinc gluconate, phosphopeptide caseinate, taurine, vitamin D3Dry
Powder, Fructus Musae powder, glucose, whole milk powder；
III group：Calcium lactate, magnesium sulfate, tricalcium phosphate, zinc gluconate, phosphopeptide caseinate, taurine, vitamin D3Dry
Powder, Fructus Musae powder, glucose, whole milk powder；
IV group：Calcium gluconate, magnesium sulfate, tricalcium phosphate, zinc gluconate, phosphopeptide caseinate, taurine, vitamin
D3Dry powder, Fructus Musae powder, glucose, whole milk powder.
Respectively I, II, III, IV group compositionss are configured to desired concn with distilled water for solvent, matched group, I, II, III,
IV group of its mouse oral gavage give respectively matched group, I, the compositionss of II, III, IV, groundwater increment is daily 2.33g compositionss/kg
Body weight, after tested 30 days of this method, carries out carbonic clearance test, result is as follows：
Table 2 monocytes/macrophages carbonic clearance Experimental Comparison result
| Group | Phagocytic index |
| Matched group | 5.47±0.60 |
| I group | 6.05±0.90 |
| II group | 5.79±0.81 |
| III group | 5.68±0.92 |
| IV group | 5.75±0.58 |
As shown in Table 2：The monocytes/macrophages carbonic clearance phagocytic index of I group of mice be above matched group, II group, III group
With IV group (P ＜ 0.05), illustrate I group of enhancing immunity effect be better than matched group, II group, III group and IV group.
Claims (5)
1. a kind of milk calcium powder promoting bone growth and enhance immunity is it is characterised in that meter by weight includes following joining
Material：
2. as claimed in claim 1 a kind of milk calcium powder promoting bone growth and enhance immunity it is characterised in that by weight
Number meter also includes Fructus Musae powder 5-50 part.
3. as claimed in claim 1 a kind of milk calcium powder promoting bone growth and enhance immunity it is characterised in that by weight
Number meter also includes glucose 10-60 part.
4. as claimed in claim 1 a kind of milk calcium powder promoting bone growth and enhance immunity it is characterised in that by weight
Number meter also includes vitamin D3Dry powder 0.0004-0.0008 part.
5. the preparation side of the milk calcium powder promoting bone growth and enhance immunity as described in a kind of any one as claim 1-4
Method, it is characterised in that routinely formulation method is prepared into powder by each dispensing, accurately weighs each dispensing, Ran Houchong first respectively
After dividing mix homogeneously, carry out subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610802756.7A CN106417619A (en) | 2016-09-05 | 2016-09-05 | Milk calcium powder for promoting skeleton growth and enhancing immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610802756.7A CN106417619A (en) | 2016-09-05 | 2016-09-05 | Milk calcium powder for promoting skeleton growth and enhancing immunity |
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| Publication Number | Publication Date |
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| CN106417619A true CN106417619A (en) | 2017-02-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109043516A (en) * | 2018-08-04 | 2018-12-21 | 安徽金源药业有限公司 | A kind of milk calcium and preparation method thereof of high nutrition absorption efficiency |
| CN109090321A (en) * | 2018-09-12 | 2018-12-28 | 吉林省修悦生物科技有限公司 | Amino-acid liquid chelates calcium preparation and preparation method thereof |
| CN110786388A (en) * | 2019-11-29 | 2020-02-14 | 成都桥然生物科技有限公司 | Milk powder for promoting growth of children and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101233874A (en) * | 2008-02-02 | 2008-08-06 | 内蒙古蒙牛乳业（集团）股份有限公司 | Liquid state milk suitable for baby from 12 to 36 months old |
-
2016
- 2016-09-05 CN CN201610802756.7A patent/CN106417619A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101233874A (en) * | 2008-02-02 | 2008-08-06 | 内蒙古蒙牛乳业（集团）股份有限公司 | Liquid state milk suitable for baby from 12 to 36 months old |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109043516A (en) * | 2018-08-04 | 2018-12-21 | 安徽金源药业有限公司 | A kind of milk calcium and preparation method thereof of high nutrition absorption efficiency |
| CN109090321A (en) * | 2018-09-12 | 2018-12-28 | 吉林省修悦生物科技有限公司 | Amino-acid liquid chelates calcium preparation and preparation method thereof |
| CN110786388A (en) * | 2019-11-29 | 2020-02-14 | 成都桥然生物科技有限公司 | Milk powder for promoting growth of children and preparation method thereof |
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Application publication date: 20170222 |
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