CN1117561C - Compounded calcium preparation, preparing method and use thereof - Google Patents

Abstract

The present invention discloses a compound calcium preparation whose main component contains a calcium preparation used as a carrier. The effective dose of other macroelements, especially compounds, such as acetate of trace elements, etc., are added. In the formulation of the present invention, the content of the calcium preparation is controlled to be from 50 to 99.5%. After the compound calcium preparation of the present invention is taken, calcium can be complemented in a high efficiency mode, and simultaneously, other macroelements, especially trace elements can be complemented in a high efficiency mode. Therefore, various chronic diseases caused by deficiency of the elements can be prevented. The present invention is good for health and longevity of a human body.

Description

Compounded calcium preparation and its production and use

The invention relates to a kind of compounded calcium preparation that contains the needed by human beneficial element, more particularly can effectively replenish compounded calcium preparation of these elements of needed by human body and its production and use about a kind of.

The macroelement of needed by human (greater than human body body weight ten thousand/more than) calcium, sodium, magnesium, sulfur, phosphorus etc. are arranged, its requirement is big, the safety range broad, content is abundanter relatively in the general food, so outside the deliming, be difficult for shortage; Essential trace element has 14 kinds in ferrum, zinc, cobalt, manganese, copper, strontium, nickel, molybdenum, chromium, iodine, selenium, vanadium, stannum, fluorine etc., and its requirement is little, and safety range is narrow, and content is very little in the general food, lacks so easily form.These elements have constituted human mineral matter nutritional, and lacked their life and just can not exist or growth retardation, but excessive also harmful.

Calcium is described as life originally, is the main matter of keeping all cell functions, is the Main Ingredients and Appearance of tooth, skeleton etc.; Calcium can activate multiple enzyme and participate in heartbeat, nerve information transmission, muscle contraction and diastole, control body fluid, blood acid-base balance and blood coagulation; It can improve blood viscosity, eliminate unnecessary blood fat and cholesterol, improves blood vessel elasticity; And can prevent toxic ionic absorption, and get rid of lactic acid, remove canceration poisonous substance on the colon film; Calcium can be strengthened myocardial function, can stimulate spermioteleosis, sexual function improvement; Calcium can stimulate the elongation factor in the ribonucleic acid.Calcium deficiency is that all are weak, the basic reason of sub-health state, affluenza and various diseases.Old people's calcium deficiency causes osteoporosis, cardiovascular disease, serious calcium deficiency can cause symptoms such as general weakness, sore waist and aching in the waist and the back, tetany, arrhythmia; That the middle age calcium deficiency causes is weak and sickly, the osteomalacia, easily knot, weak, climacteric in advance and reaction is big, early whitening of beard and hair, back The symptoms of aging in advance such as camel early; Child's calcium deficiency influence is grown, cause rickets, also can bring out cry night, night sweat, tetany, convulsion, even can cause death because of the throat spasm.The human body calcium deficiency is a worldwide problem, is thought a difficult problem by physician and nutritionist for a long time and replenish the calcium always.The source of calcium is mainly by meals in the Chinese visible human, and in the meals calcium contain quantity not sufficient, so the general calcium deficiency of Chinese, especially old people, women, child are even more serious.China NI be specified to the people day by day the calcium amount be 800 milligrams (1000 milligrams in U.S.), this can be surveyed on average only has 400 milligrams for the calcium amount China's standard diet day, differs from 400 milligrams.And old man, anemia of pregnant woman, wet nurse day by day the calcium amount so replenish 300 milligrams～400 milligrams calcium every day and be fit to more than 1500 milligrams.

Ferrum is important elements such as human body hemopoietic, information transmission, nutrition, oxygen delivery, metabolism, and iron deficiency can cause diseases such as anemia, hypoimmunity.Current iron deficiency anemia is one of modal Deficiency disease of Chinese children, and the ratio of students in middle and primary schools' iron deficiency anemia is about about 50%.

Zinc is the component and the activation factor of hundreds of enzymes such as carbonic acid enzyme, DNA and RNA polymerase, participates in ribozyme and protein synthesis, keeps cellularity and function, improves immune function of human body.Zinc deficiency makes people's inappetence, growth retardation, stupid, hypoimmunity.Current, to zinc content analysis in 19 provinces and cities' preschooler hairs such as Beijing, nearly 60% child is lower than normal value according to relevant department; Zinc wretched insufficiency among the student, students in middle and primary schools' zinc deficiency reaches 30%.

Cobalt occupies the monarch status in 14 kinds of essential trace elements, other various trace element are regulated and control by it all; Cobalt participates in skeleton hemopoietic, promotes erythrocytic growth and maturation, promotes nucleic acid and protein synthesis nucleoprotein, and is also relevant with cardiovascular growth and metabolism; Cobalt is a vitamin B ₁₂Composition, vitamin B ₁₂Lacking then influences hemopoietic function.

Manganese is the component and the activator (as SOD) of many important enzymes, and is the important factor of biochemical process such as oxidoreduction, participates in protein, vitamin B, the synthetic and hereditary information transmission of C, E, can promote skeleton to form and gonad development, can promote insulin action; Participate in hematopoiesis, increase the utilization of fat, raise immunity helps the control of cancer, schizophrenia and diabetes; Have the scholar to point out, contain manganese superoxide dismutase (Mn, SOD) to the elimination factor of superoxide radical up to 70%, superoxide radical is aged principal element, so manganese is the long-lived element of anti-senility.

Strontium is the component of skeleton and tooth, and the formation of itself and skeleton is in close relations; The absorption and the drainage of energy balance sodium; With cardiovascular function and construct relevant, can prophylaxis of hypertension etc. cardiovascular disease; Calcium ion concentration difference inside and outside safeguarding cell membrane is played an important role.

Selenium is described as the natural jinx of cancer, and selenium has the effect that keeps thymus, keeps lymphocyte activity and enhancing antibody formation, thereby improves human immune system's anti-cancer ability.Selenium is also to the number of chemical carcinogen, especially flavacin B ₁Has tangible destruction.Selenium can strengthen the activity of superoxide dismutase and glutathione oxidase, thereby can remove free radical, to affluenza, as diabetes, hyperlipidemia, hyperlipidemia etc. effect is well arranged obviously, and selenium also is one of necessary element of children ' s intelligence development simultaneously.

Above-mentioned beneficial element all contains in food, but content is abundant, and all to need the gastric acid digest and decompose be could be by intestinal absorption after the ionic state.If the gastric acid deficiency is then decomposed insufficiently, just be difficult to absorb, so easily cause these elements of shortage in the body.The acetate of these metallic elements belongs to ionic compound, and soluble in water and ionization immediately is metallic element cation and acetate anion; The former plays the effect that replenishes these elements easily by intestinal absorption; The latter can play the same multiple important physiological function of vinegar, and have good bactericidal action after being absorbed in the human body, and this is the peculiar advantage of acetate, is that other any calcium preparation are incomparable.

Up to now, the inventor does not find to have on the market " compounded calcium preparation " sale as replenishing the calcium and replenishing other elements effectively as yet, finds no the bibliographical information of this respect yet.

One of purpose of the present invention provides a kind of prior art existing problems of overcoming, and is human high efficiency calcium-enriching and the efficient compounded calcium preparation that replenishes other magnanimities, particularly trace element.

Two of purpose of the present invention provides a kind of in high efficiency calcium-enriching, can efficiently replenish other magnanimities, particularly trace element again, with control for want of these elements and the multiple disease that causes, thereby keeps fit and the compounded calcium preparation of life lengthening.

Three of purpose of the present invention provides a kind of preparation method of compounded calcium preparation.

These and other purpose of the present invention will further be illustrated by following detailed description and explanation.

Compounded calcium preparation of the present invention comprises the calcium preparation as carrier, has also added the acetate of other useful magnanimity, particularly trace element of effective dose and the beneficial element chemical compound of other kind, and wherein calcium preparation content is 50～99.5 weight %.

In compounded calcium preparation of the present invention, metallic element in the described calcium preparation and nonmetalloid can be manganese, selenium, ferrum, zinc, cobalt, copper, magnesium etc., can add one or more separately, except the sulfate; The content of the beneficial element chemical compound (except that calcium preparation) of the acetate of described other useful magnanimity, particularly trace element and other kind is 0.01～35 weight %; The particle diameter of product and is powdery and nearly neutral compounded calcium preparation between 0.1～10 micron; As the calcium preparation of carrier can be in calcium acetate, calcium gluconate, calcium lactate, calcium carbonate, l threonic acid, calcium ascorbate, amino acid calcium, calcium citrate, activated calcium, calcium hydrogen phosphate and the animal bone calcium one or more.

Compounded calcium preparation of the present invention can prepare by the following method, and its processing step comprises:

A, recipe design need to select the various elements of interpolation by actual requirement, the standard volume that need take in this element everyone every day or the actual required amount of formulating by national NI again, calculate the prescription of various element allied compounds, can calculate the weight that it needs at last; The average gross weight of mineral element that the adult needs to lack easily every day is 1044.9 milligrams, and the prescription value of each element is: calcium is 95.7029%, and manganese is 0.3589%, selenium is 0.0144%, and ferrum is 1.9141%, and zinc is 1.4355%, strontium is 0.1914%, and cobalt is 0.3828%.The people of other age brackets can do analogy with the day requirement of the calcium of being grown up.Reference when above-mentioned element combinations and prescription value are only specifically implemented can be taken the circumstances into consideration to adjust.But must be noted that, trace element, especially selenium, its safety range very narrow (selenium is 0.05-0.28 milligram/day only), careless slightly can working the mischief is in peril of one's life slightly at most, so safety coefficient would rather design greatly.

B, by the prescription requirement accurately weigh up needed all cpds;

C, to above-mentioned various powderies batching, with equivalent incremental method mix homogeneously, and after placing agitator to stir, pour out and be loaded in the container;

D, above-mentioned abortion product are made tablet, capsule and electuary through after the assay was approved.

Compounded calcium preparation of the present invention also can prepare by the following method, and its processing step comprises:

A, recipe design: various elements that need to select interpolation by actual requirement, the standard volume that need take in this element everyone every day or the actual required amount of formulating by national NI again, calculate the prescription of various element allied compounds, can calculate the weight that it needs at last; The average gross weight of mineral element that the adult needs to lack easily every day is 1044.9 milligrams, and the prescription value of each element is: calcium is 95.7029%, and manganese is 0.3589%, selenium is 0.0144%, and ferrum is 1.9141%, and zinc is 1.4355%, strontium is 0.1914%, and cobalt is 0.3828%.The people of other age brackets can do analogy with the day requirement of the calcium of being grown up.Reference when above-mentioned element combinations and prescription value are only specifically implemented can be taken the circumstances into consideration to adjust.But must be noted that, trace element, especially selenium, its safety range very narrow (selenium is 0.05-0.28 milligram/day only), careless slightly can working the mischief is in peril of one's life slightly at most, so safety coefficient would rather design greatly.

B, by the prescription requirement accurately measure the required various compound solution of having measured concentration;

C, place container to stir the above-mentioned solution batching after, import again and promptly get compounded calcium preparation in spray dryer or the vaporizer after the evaporation drying;

D, above-mentioned compounded calcium preparation are made tablet, capsule and electuary through after the assay was approved.

In the present invention, with the big calcium preparation of requirement is carrier, and other function is huge, that requirement is little acetate and other kind beneficial element chemical compound participate in wherein in required ratio, make compounded calcium preparation, to mend these necessary various elements again when replenishing the calcium.Everyone requirement every day of various elements in this kind calcium preparation, the standard of formulating with reference to China NI and drafting sees table 1 for details.

The easy beneficial element day requirement milligram that lacks/day table 1

Age	0-1	2-9	10-18	The adult	The old man	The anemia of pregnant woman	Wet nurse
								Calcium Ca 2+	400-600	600-800	1000-1200	800-1200	1200-2000	1500	2000
Manganese Mn 2+	0.5-1	1-2	2.5	2.5-5
								Selenium Se 2-				0.05-0.25
Ferrum Fe 2+	3-5	10	12	20		25
								Zinc Zn 2+	3	10	15	15		20	25
Strontium Sr 2+				2
								Cobalt Co 2+	0.3	0.9-1.5	2	3.5		3	2.5

Can converse acetate weight and nonmetalloid chemical compound weight according to element wt in the table 1.

In the present invention, the compounded calcium preparation main component comprises the calcium preparation as carrier, as calcium acetate (CH ₃COO ₂) ₂Ca, Ca25.316%, and the beneficial metallic elements acetate of other effective doses are as manganese acetate (CH ₃COO ₂) ₂Mn, Mn31.752%; Ferrous acetate (CH ₃COO ₂) ₂Fe, Fe32.106%; Zinc acetate (CH ₃COO ₂) ₂Zn, Zn35.66%; Strontium acetate (CH ₃COO ₂) ₂Sr, Sr42.607%; Inferior cobalt (the CH of acetic acid ₃COO ₂) ₂Co, Co33.296% or the like also can add the beneficial element chemical compound of other an amount of kind, as three sodium selenate Na ₂SeO ₃, Se45.633% or selenic acid H ₂SeO ₄, Se54.451% or Monohydrated selenium dioxide H ₂SeO ₃, Se61.210% or the like.As for the shared ratio of required beneficial element (prescription), be to measure as required and decide generally, be exactly everyone requirement every day standard of formulating according to China NI specifically, with following formula calculating:

Must point out emphatically herein,, only be to replenish various beneficial elements general, and requirement is cancelled or reduced to wantless element, also not give outstanding the element that lacks with the prescription that said method is designed.For to the special requirement of certain areas, some crowd to some beneficial element, also wantless element can be cancelled, the beneficial element that lacks is increased very much, but calcium can not be cancelled.In the case, it is same as described above to calculate the method that element distributes, and element combinations and ratio thereof in the compounded calcium preparation in a word must depend on actual need and decide, like this competence exertion its should produce effect.

Product of the present invention is because of the chemical compound of other magnanimities, the particularly trace element that have added effective dose, so edible back is except that having the effect of replenishing the calcium significantly, also has the good effect of replenishing other magnanimities, particularly trace element simultaneously, thereby can prevent and treat the multiple chronic disease that causes because of calcium deficiency and other macroelements, help the healthy and long-lived of people.This product can directly make an addition in boiled water, beverage and the meals edible in right amount, also is suitable for food industry and makes functional food.

In the present invention, employed calcium acetate, be the unparalleled precious Group Co.,Ltd in the Guangdong patent " Preparation method and use of calcium acetate " utilizing Lee and become for a long time (patent No.: ZL90106957.4) and Development and Production, so can be described as the significant improvement of preceding patent.

In the present invention, if not refer in particular to, all parts, amount are the unit of weight based on gross weight.

Below by specific embodiment further specify the present invention but embodiment only be used for the explanation, can not limit the scope of the invention.

Example 1:

A kind of is " the anticancer longevity ions of manganese selenium type acetate " that the adult eats in the manganese deficiency formation hepatocarcinoma district occurred frequently specially:

A, recipe design table: table 2

Element		The chemical compound of this element
					Title	Day requirement (milligram/day)	Title	The weight milligram	Prescription value (%)
Calcium	800	Pure anhydrous calcium acetate	3160.057	98.4182
					Manganese Mn 2+	10	Manganese acetate	31.4941	0.9809
Selenium	0.1	Three sodium selenate	0.2191	0.0068
							Impurity (in the calcium acetate)	19.075	0.5941
		Add up to	3210.8452	100.000

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 3210.8452 milligrams=24.9156%; Manganese content=10 milligram ÷ 3210.8452 milligrams=0.3114%; Se content=0.1 milligram ÷ 3210.8452 milligrams=0.0031%;

C, preparation method: get purity and be 10 kilograms of 99.4% acetic acid calcium powder products, calculating pure anhydrous calcium acetate is 9940 grams, and calculating total amount of compound by calcium acetate prescription value 98.4182% in the table 2 again is 10099.8 to restrain, so:

Need manganese acetate=10099.8 gram * 0.9809%=99.069 gram;

Need three sodium selenate=10099.8 gram * 0.0068%=0.687 gram

The calcium acetate, manganese acetate, three sodium selenate that weigh up are put container with equivalent incremental method mix homogeneously, put in the blender and stir, take out then, its theoretical weight and content are:

Calcium weight=9940 gram * 25.316%=2516.410 gram;

Manganese weight=99.069 gram * 31.752%=31.456 gram;

Selenium weight=0.687 gram * 45.633%=0.313 gram;

Calcium content=2516.410 gram ÷, 10099.8 grams=24.915%;

Manganese content=31.456 gram ÷, 10099.8 grams=0.3115%;

Se content=0.313 gram ÷, 10099.8 grams=0.0031%;

Above-mentioned trial product is through the test of Guangzhou test center, and calcium content is 24.87%, and manganese is 0.32%, and selenium is 0.003%, with above-mentioned theory value basically identical.

D, to the commentary of test products: this product is white powder, and is soluble in water, and the solution mouthfeel is light as water, 10 milligrams of manganese content, 0.1 milligram of Se content.Therefore, even at 400 milligram hours of replenishing the calcium, also can mend 5 milligrams in manganese (being equivalent to 27.8 kilograms of manganese in the beef) simultaneously, 0.05 milligram of selenium supplement.The Shaanxi Ziyang tea contains manganese 0.653ppm, quite is subjected to domestic and international attention, is 47 times of Ziyang tea and this product contains selenium.Because to contain manganese and the selenium that can prevent and treat cancer suitable for this product, have no side effect during correct consumption, so should become the good preparation of preventing and treating carninomatosis such as hepatocarcinoma, have very considerable DEVELOPMENT PROSPECT, will obtain huge social and economic benefit.

Example 2:

Special " the Fructus Alpiniae Oxyphyllae ionic iron of the enriching blood zinc type calcium acetate " that eats for the iron deficiency anemia child

A, recipe design table table 3

Element		The chemical compound of this element
					Title	Day requirement (milligram/day)	Title	The weight milligram	Prescription value (%)
Calcium	800	Pure anhydrous calcium acetate	3160.057	98.188

Ferrum	9	Ferrous acetate	28.032	0.871
					Zinc	4	Zinc acetate	11.217	0.349
		Impurity (in the calcium acetate)	19.075	0.593
							Add up to	3218.381	100

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 3218.381 milligrams=24.857%; Iron content=9 milligram ÷ 3218.381 milligrams=0.280%; Zinc content=4 milligram ÷ 3218.381 milligrams=0.124%;

C, preparation method: get purity and be 10 kilograms of 99.4% acetic acid calcium powder products, calculating and closing pure anhydrous calcium acetate is 9940 grams, and calculating total amount of compound by calcium acetate prescription value 98.188% in the table 1 again is 10123.4 to restrain, therefore:

Need Ferrous acetate=10123.4 gram * 0.871%=88.175 gram;

Need zinc acetate=10123.4 gram * 0.349%=35.331 gram.

With calcium acetate, Ferrous acetate, the zinc acetate that weighs up, put in the container with equivalent incremental method mix homogeneously, put in the blender again and stir evenly, take out then, its theoretical weight and content are:

Calcium weight=9940 gram * 25.316%=2516.410 gram

Ferrum weight=88.175 gram * 32.106%=28.309 gram

Zinc weight=35.331 gram * 35.66%=12.599 gram

Calcium content=2516.410 gram ÷, 10123.4 grams=24.857%

Iron content=28.309 gram ÷, 10123.4 grams=0.280%

Zinc content=12.599 gram ÷, 10123.4 grams=0.124%

The said goods is through the test of Guangzhou test center, and calcium content is 24.83%, and ferrum is 0.27%, and zinc is 0.12%, with above-mentioned theory value basically identical.

D, to the commentary of product: this product is white powder, and is soluble in water, and the solution mouthfeel is light as water.Considers and all contain ferrum, zinc in the general food, and meal structures for children difference is big, iron deficiency, zinc degree difference, and take in ferrum, zinc is careless slightly causes excessive meeting to cause bigger toxic and side effects; Moreover the child adjustment ability, toleration is low, thus when component design temporary transient standard (3～12 milligrams/day of ferrum, 3～15 milligrams/day on zinc) in accordance with regulations not, and only be designed to: when 9 milligrams/day of ferrum, 4 milligrams/day on zinc, to increase safety.When replenishing the calcium (being equivalent to 22 kilograms of calcium amounts in the beef) 400 milligrams/day the time, 4.5 milligrams of iron supplement (being equivalent to the ferrum amounts in the 349 gram beef) simultaneously still, 2 milligrams of zinc supplements (being equivalent to the zinc amount in the 109 gram beef) are so ferrum, zinc content still are significant in the product.China iron deficiency anemia child is very general at present, so this product has very considerable DEVELOPMENT PROSPECT, will obtain huge social and economic benefit.

Example 3:

A kind ofly special form " the anticancer anti-aging manganese selenium type calcium acetate " that hepatocarcinoma and other cancers crowd eat, former calcium acetate content 99.4% for trace element such as manganese deficiencies.

A, recipe design: in adult's daily requirement amount (milligram)

Element		This element need chemical compound
						Title	Day requirement (/ day)	Title	Constituent content (%)	Weight (mg)	Prescription value (%)
Calcium Ca 2+	800	Pure anhydrous calcium acetate	25.3402	3157.0390	98.2856
						Manganese Mn 2+	10	Manganese acetate	31.7514	31.4947	0.9805
Selenium Se 4+	0.05	Three sodium selenate	45.6395	0.1096	0.0034
						Cobalt Co 2+	1	The inferior cobalt of acetic acid	33.2917	3.0030	0.0935
Zinc Zn 2+	0.5	Zinc acetate	35.6358	1.4031	0.0437
								Impurity (containing in the calcium powder)		19.0566	0.5933
		Add up to		3212.1068	100.0000

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 3212.1068 milligrams=24.9058%, manganese content=10 milligram ÷ 3212.1068 milligrams=0.3113%, Se content=0.05 milligram ÷ 3212.1068 milligrams=0.0016%, cobalt content=1 milligram ÷ 3212.1068 milligrams=0.0311%, zinc content=0.5 milligram ÷ 3212.1068 milligrams=0.0156%, content of strontium=0.023%, (rice contains selenium 0.025ppm, and the 2kg rice contains selenium 50ug)

C, preparation method are similar to example 2.Product is through the test of Guangzhou test center, and constituent content and above theoretical value are basic identical.

Example 4

Another kind of " the Fructus Alpiniae Oxyphyllae ionic iron of the enriching blood zinc cobalt type calcium acetate " that eats for the iron deficiency anemia child specially: former calcium acetate content 99.4%.

A, recipe design table: in adult's daily requirement amount (mg)

Element		This element need chemical compound
						Title	Day requirement (mg/ day)	Title	Constituent content (%)	Weight (mg)	Prescription value (%)
Calcium Ca 2+	800	Pure anhydrous calcium acetate	25.3402	3157.0390	98.2350
						Ferrum Fe 2+	8	Ferrous acetate	32.1053	24.9180	0.7754
Zinc Zn 2+	4	Zinc acetate	35.6358	11.2247	0.3493
						Cobalt Co 2+	0.5	The inferior cobalt of acetic acid	33.2917	1.5019	0.0467
Selenium Se 4+	0.01	Three sodium selenate	45.6395	0.0219	0.0007
								Impurity (in the calcium acetate)		19.0566	0.5930
		Add up to		3213.7621	100.00

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 3213.7621 milligrams=24.8929%, iron content=8 milligram ÷ 3213.7621 milligrams=0.2489%, zinc content=4 milligram ÷ 3213.7621 milligrams=0.1245%, cobalt content=0.5 milligram g ÷ 3213.7621 milligrams=0.0156%, Se content=0.01 milligram ÷ 3213.7621 milligrams=0.0003%

C, preparation method are similar to example 2.Product is through the test of Guangzhou test center, and constituent content and above theoretical value are basic identical.

Example 5

The balanced compound calcium acetate that replenishes the nutrition of main mine material is as men and women, old and young, and is daily edible, former calcium acetate content 99.4%.

A, recipe design table: in adult's daily requirement amount (milligram)

Element		This element need chemical compound
						Title	Day requirement (mg/ day)	Title	Constituent content (%)	Weight (mg)	Prescription value (%)
Calcium Ca 2+	800	Pure anhydrous calcium acetate	25.3402	3157.0390	52.9135
						Magnesium Mg 2+	325	Magnesium acetate	17.0690	1904.0365	31.9126
Potassium K 1+	300	Potassium acetate	39.8383	753.0442	12.6214
						Manganese Mn 2+	3.75	Manganese acetate	31.7514	11.8105	0.1979
Selenium Se 4+	0.15	Three sodium selenate	45.6395	0.3287	0.0055
						Ferrum Fe 2+	20	Ferrous acetate	32.1053	62.2950	1.0441
Zinc Zn 2+	15	Zinc acetate	35.6358	42.0925	0.7055
						Strontium Sr 2+	2	Strontium acetate	42.5945	4.6954	0.0787
Cobalt Co 2+	4	The inferior cobalt of acetic acid	33.2917	12.0150	0.2014
								Impurity (in the calcium acetate)		19.0566	0.3194
		Add up to		5966.4134	100.0000

B, the constituent content theoretical value is calculated: calcium content=800 milligram ÷ 5966.4134 milligrams=13.4084%, content of magnesium=325 milligram ÷ 5966.4134 milligrams=5.4472%, potassium content=300 milligram ÷ 5966.4134 milligrams=5.0281%, manganese content=3.75 milligram ÷ 5966.4134 milligrams=0.0629%, Se content=0.15 milligram ÷ 5966.4134 milligrams=0.0025%, iron content=20 milligram ÷ 5966.4134 milligrams=0.3352%, zinc content=15 milligram ÷ 5966.4134 milligrams=0.2514%, content of strontium=2 milligram ÷ 5966.4134 milligrams=0.0335%, cobalt content=4 milligram ÷ 5966.4134 milligrams=0.0670%

C, preparation method are similar to example 2.Product is through the test of Guangzhou test center, and constituent content and above theoretical value are basic identical.

Example 6:

With the calcium gluconate is " the anticancer anti-aging manganese selenium type calcium gluconate " of preparing carriers, former gluconic acid calcium content 99.0%.

A, recipe design table: in adult's daily requirement amount (milligram)

Element		This element need chemical compound
						Title	Day requirement	Title	Constituent content (%)	Weight (mg)	Prescription value (%)
Calcium Ca 2+	800	Pure anhydrous grape saccharic acid calcium	9.3023	8600.0236	89.6621
						Manganese Mn 2+	10	Manganese acetate	31.7514	31.4947	0.3284
Selenium Se 4+	0.05	Three sodium selenate	45.6395	0.1096	0.0011
						Cobalt Co 2+	1	The inferior cobalt of acetic acid	33.2917	3.0038	0.0313
Zinc Zn 2+	0.5	Zinc acetate	35.6358	1.4031	0.0146
								Impurity (in the calcium gluconate)		955.5582	9.9625
		Add up to		9591.5930	100.0000

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 9591.5930 milligrams=8.3406% manganese content=10 milligram ÷ 9591.5930 milligrams=0.1043% Se content=0.05 milligram ÷ 9591.5930 milligrams=0.0005% cobalt content=1 milligram ÷ 9591.5930 milligrams=0.0104% zinc content=0.5 milligram ÷ 9591.5930 milligrams=0.0052%

C, preparation method are similar to example 2.Product is through the test of Guangzhou test center, and constituent content and above theoretical value are basic identical.

Example 7

With the l threonic acid is carrier system " the Fructus Alpiniae Oxyphyllae ionic iron of enriching blood zinc cobalt type l threonic acid ", former l threonic acid content 99.0%

A, recipe design table: in adult's daily requirement amount (milligram)

Element		This element need chemical compound
						Title	Day requirement	Title	Constituent content (%)	Weight (mg)	Prescription value (%)
Calcium Ca 2+	800	Pure anhydrous l threonic acid	12.9032	6200.0124	89.4381
						Ferrum Fe 2+	8	Ferrous acetate	32.1053	24.9180	0.3595
Zinc Zn 2+	6	Zinc acetate	35.6358	16.8370	0.2429
						Cobalt Co 2+	0.5	The inferior cobalt of acetic acid	33.2917	1.5019	0.0217
Selenium Se 4+	0.01	Three sodium selenate	45.6395	0.0219	0.0003
								Impurity (in the l threonic acid)		688.8903	9.9376
		Add up to		6932.1015	100.0001

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 6932.1015 milligrams=11.5404% iron content=8 milligram ÷ 6932.1015 milligrams=0.1154% zinc content=6 milligram ÷ 6932.1015 milligrams=0.0866% cobalt content=0.5 milligram ÷ 6932.1015 milligrams=0.0072% Se content=0.01 milligram ÷ 6932.1015 milligrams=0.0001%

C, preparation method are similar to example 2.Product is through the test of Guangzhou test center, and constituent content and above theoretical value are basic identical.

Example 8

With the calcium carbonate is balanced " composite calcium carbonate " that replenishes the nutrition of main mine material of preparing carriers, orthocarbonic acid calcium content 98.0%.

A, recipe design table: in adult's daily requirement amount (milligram)

Element		This element need chemical compound
						Title	Day requirement	Title	Constituent content (%)	Weight (mg)	Prescription value (%)
Calcium Ca 2+	800	Pure Carbon Dioxide calcium	40.0000	2000.0000	39.5882
						Magnesium Mg 2+	325	Magnesium acetate	17.0690	1757.5722	34.7895
Potassium K 1+	300	Potassium acetate	39.8383	753.0442	14.9058
						Manganese Mn 2+	3.75	Manganese acetate	31.7514	11.8105	0.2338
Selenium Se 4+	0.15	Three sodium selenate	45.6395	0.3287	0.0065
						Ferrum Fe 2+	20	Ferrous acetate	32.1053	62.2950	1.2331
Zinc Zn 2+	15	Zinc acetate	35.6358	42.0925	0.8332
						Strontium Sr 2+	2	Strontium acetate	42.5945	4.6954	0.0929
Cobalt Co 2+	4	The inferior cobalt of acetic acid	33.2917	12.0150	0.2378
								Impurity (in the calcium carbonate)		408.1633	8.0792
		Add up to		5052.0168	100.0000

B, constituent content theoretical value are calculated: calcium content=800 milligram ÷ 5052.0168 milligrams=15.8353% content of magnesium=325 milligram ÷ 5052.0168 milligrams=5.9382% potassium content=300 milligram ÷ 5052.0168 milligrams=5.9382% manganese content=3.75 milligram ÷ 5052.0168 milligrams=0.0742% Se content=0.15 milligram ÷ 5052.0168 milligrams=0.0030% iron content=20 milligram ÷ 5052.0168 milligrams=0.3959% zinc content=15 milligram ÷ 5052.0168 milligrams=0.2969% content of strontium=2 milligram ÷ 5052.0168 milligrams=0.0396% cobalt content=4 milligram ÷ 5052.0168 milligrams=0.0792%

C, preparation method are similar to example 2.Product is through the test of Guangzhou test center, and constituent content and above theoretical value are basic identical.

Claims (6)

1, a kind of compounded calcium preparation, comprise calcium preparation as carrier, it is characterized in that: also added the acetate of other useful magnanimity, particularly trace element of effective dose and the beneficial element chemical compound of other kind, wherein calcium preparation content is 50～99.5 weight %, the content of the beneficial element chemical compound (except that calcium preparation) of the acetate of trace element and other kind is 0.01～35 weight %, the particle diameter of product is powdery and near neutral between 0.1～10 micron.

2, compounded calcium preparation as claimed in claim 1 is characterized in that: metallic element in the described calcium preparation and nonmetalloid can be manganese, selenium, ferrum, zinc, cobalt, copper, magnesium etc., can add one or more separately.

3, compounded calcium preparation as claimed in claim 1 is characterized in that calcium preparation as carrier can be one or more in calcium acetate, calcium gluconate, calcium lactate, calcium carbonate, l threonic acid, calcium ascorbate, amino acid calcium, calcium citrate, activated calcium, calcium hydrogen phosphate and the animal bone calcium.

4, as the preparation method of the described compounded calcium preparation of claim 1～3, its processing step comprises:

A, recipe design: various elements that need to select interpolation by actual requirement, the standard volume that need take in this element everyone every day or the actual required amount of formulating by national NI again, calculate the prescription of various element allied compounds, can calculate the weight that it needs at last;

B, by the prescription requirement accurately weigh up needed all cpds;

C, to above-mentioned various powderies batching, with equivalent incremental method mix homogeneously, and after placing agitator to stir, pour out and be loaded in the container;

D, above-mentioned abortion product are made tablet, capsule and electuary through after the assay was approved.

5, as the preparation method of the described compounded calcium preparation of claim 1～3, its processing step comprises:

A, recipe design: various elements that need to select interpolation by actual requirement, the standard volume that need take in this element everyone every day or the actual required amount of formulating by national NI again, calculate the prescription of various element allied compounds, can calculate the weight that needs;

B, by the prescription requirement accurately measure the required various compound solution of having measured concentration;

C, place container to stir the above-mentioned solution batching after, import again and promptly get compounded calcium preparation in spray dryer or the vaporizer after the evaporation drying;

D, above-mentioned compounded calcium preparation are made tablet, capsule and electuary through after the assay was approved.

6, as the described compounded calcium preparation of claim 1～3, it is characterized in that its can do edible and medicinal, both can high efficiency calcium-enriching, can efficiently replenish particularly trace element of other magnanimities again simultaneously.