CN1112214C - Organic trace elements supplement - Google Patents

Organic trace elements supplement Download PDF

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Publication number
CN1112214C
CN1112214C CN99124691A CN99124691A CN1112214C CN 1112214 C CN1112214 C CN 1112214C CN 99124691 A CN99124691 A CN 99124691A CN 99124691 A CN99124691 A CN 99124691A CN 1112214 C CN1112214 C CN 1112214C
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selenium
zinc
semen
vitamin
trace element
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CN1263774A (en
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王将克
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Abstract

The present invention relates to an organic-state micro element supplementing agent, wherein a middle-age and old-age people's organic-state micro element supplementing agent is prepared from selenium-containing soybean flour, germanium-containing soybean flour, vitamin E and vitamin C, a children's organic-state micro element supplementing agent is prepared from zinc-containing soybean flour, selenium-containing soybean flour, germanium-containing soybean flour, vitamin C, vitamin E and L-lysine, and the diabetes people's organic-state micro element supplementing agent is prepared from chromium-containing soybean flour, vanadium-containing soybean flour, lithium-containing soybean flour, selenium-containing soybean flour and zinc-containing soybean flour. The present invention uses the organic-state trace elements according to different special people's characteristics and uses the synergistic effect among the trace elements for preparation so as to be helpful for the human body's effective absorption.

Description

Organic state micro element supplement agent
The present invention relates to field of health care products, particularly be suitable for the organic state micro element supplement agent that middle-aged and elderly people, diabetes patient, juvenile eat.
Trace element has inorganic states and organic two kinds of existence forms, for example ZnSO 4, Na 2SeO 3, GeO 2Deng being the inorganic states trace element.ZnSO for example 4, Na 2SeO 3, GeO 2, CrCl 3Bio-ligand complex (as germanium yeast, chromium yeast, zinc yeast etc.) and self transform by biological, promptly to generate amino-acid zinc, aminoacid selenium etc. with organic acid in the organism (as aminoacid) complexation be organic state micro element to the inorganic states trace element.
The trace element replenisher product of selling on the existing market is as " Theragran ", " Centrum " etc., and trace element wherein all is trace element of inorganic states, and the absorption of human body utilization rate is low.Trace element composition and proportioning are not prepared at the health of different crowd in these class health product, and for example common complaint among the elderly is cancer, cardiovascular diseases, diabetes, hepatitis B etc., and selenium (Se) is relevant with lacking, and needs Selenium Supplement especially; Glucose tolerance factor reduces and shortage chromium (Cr in diabetes patient's the body 3+) relevant, need to replenish chromium; Grow up healthy and sound process and zinc (Zn), lysine content such as the increasing of juvenile, intelligence is relevant, needs to replenish.
Have only single vitamin E or its health product to sell for example oral capsule, skincare product etc. now on the market.Relevant trace element health-care product are also more single.Do not make full use of trace element-selenium and germanium synergism, do not make full use of the coordinative role of selenium and vitamin E yet Human Physiology.
The objective of the invention is to overcome the deficiencies in the prior art part, characteristics at middle-aged and elderly people, a kind of middle-aged and elderly people trace element replenisher are provided, use organic state micro element, and utilize synergism between the trace element and the coordinative role between trace element and the vitamin, be beneficial to human body and effectively absorb.
The objective of the invention is to overcome the deficiencies in the prior art part, characteristics at the juvenile, a kind of juvenile's organic state micro element supplement agent is provided, use organic state micro element, and utilize synergism between the trace element and the coordinative role between trace element and the vitamin, be beneficial to human body and effectively absorb.
The objective of the invention is to overcome the deficiencies in the prior art part, characteristics at the diabetes patient, a kind of diabetes patient's organic state micro element supplement agent is provided, use organic state micro element, and utilize synergism between the trace element and the coordinative role between trace element and the vitamin, be beneficial to human body and effectively absorb.
Middle-aged and elderly people organic state micro element supplement agent weight of the present invention is composed as follows:
Contain selenium Semen Glycines powder 10-40 part
Germanic Semen Glycines powder 10-88 part
1 part of vitamin E
Vitamin C 1-3 part
This prescription is according to human body the daily requirement of mentioned component to be prepared.
Middle-aged and elderly people organic state micro element supplement agent of the present invention uses contains selenium Semen Glycines powder, germanic Semen Glycines powder, can obtain with the nutritional solution soaking beans kind, the accelerating germination that contain trace element-selenium or germanium by the method for soilless culture.The concrete preparation method that contains selenium, germanium Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water.
The used nutritional solution that contains trace element of seed soaking can be that selenium concentration is the Na of 50-100 microgram/gram in the first step 2SeO 3Solution etc., or germanium concentration is the GeO of 50-1000 microgram/gram 2Solution etc.
Above-mentioned germinating cabinet can be the germinating cabinet of existing cultivation apparatus without soil, for example the cultivation case of lucifuge, cultivation box, germinating cabinet etc.
Selenium has the important physical effect to human body, is one of extremely important trace element.But its delaying human body caducity, anti-curing cancers, cardiovascular diseases, hepatic necrosis, hemolytic anemia, Keshan disease and Kaschin-Beck disease etc. also can improve people's vision, and old friend's body selenium supplement seems particularly important.
Selenium in the human body mainly depends on the Se content in the food, and it is low that low selenium area growing plants contains the Se amount, and the selenium disease just takes place to lack humans and animals easily.For example the cause of disease of Keshan disease and Kaschin-Beck disease is exactly to lack selenium, and relevant with multiple disease, as white muscle disease, exudative diathesis disease, reproductive capacity go down, disease such as digestive function obstacle.Take the photograph the selenium amount every day when human body and be lower than 22 micrograms, also can cause scarce selenium.
Trace element germanium has the function of enhancing immunity and resistance, anticancer, defying age and the multiple disease of treatment.There are some researches show that per day for adults is on average taken in the germanium of 0.4~3.7mg, can promote health, regulate physiological function, treatment tumor, antiinflammatory, antibiotic etc.A lot of germanium compounds are biologically active all, wherein especially with natural organic germanium, single organic germanium sesquioxide and sulfide and GeO 2Some bio-ligand complex (as germanium yeast) etc. higher nutritive value is arranged.
Selenium and germanium exist synergism on physiological function.Selenium and germanium all have different physiological roles, they to improve immunity, antioxidation, aspect such as anticancer plays an important role.Selenium---germanium mixed liquor is in the effect that promotes immunologic function, antioxidation, aspect such as anticancer, and the effect of using separately than selenium, germanium is bigger.Aspect the removing living radical, selenium and germanium also exist synergism; Germanium also has the selenic toxic action of antagonism.
There are following rapport in selenium and vitamin E biologically: selenium is a kind of strong oxidizer, and its effect is similar to vitamin E, but effectiveness is bigger, and is higher approximately 500 times than vitamin E as the oxidation resistance of selenoprotein.Selenium is to work by glutathion peroxidase (GSH-Px), is present in the cytoplasm, works to remove the peroxide that has formed.Vitamin E mainly is positioned on the biomembrane, by the blocking-up radical chain reaction, attacks with the membranous free radical of avoiding of protection cell membrane system.
Because the antioxidation point of Se and vitamin E is different, though both have many similarities aspect anti-oxidative damage, can show as both and play complementary action, even lack that either party is inoperative also showing aspect certain, only when The combined, just can give full play to the effect of the anti-damage of antioxidation.
Juvenile's organic state micro element supplement agent weight of the present invention is composed as follows:
Contain zinc Semen Glycines powder 30-50 part
Contain selenium Semen Glycines powder 10-40 part
Germanic Semen Glycines powder 10-88 part
Vitamin C 1-3 part
1 part of vitamin E
L-lysine 10-20 part
This prescription is according to human body the daily requirement of mentioned component to be prepared.
The present invention uses contains selenium Semen Glycines powder, germanic Semen Glycines powder, contain the zinc Semen Glycines powder, can obtain with the nutritional solution soaking beans kind, the accelerating germination that contain trace element-selenium or germanium or zinc by the method for soilless culture.Contain selenium, concrete preparation method germanic, that contain the zinc Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water.
The used nutritional solution that contains trace element of seed soaking can be that selenium concentration is the Na of 50-100 microgram/gram in the first step 2SeO 3Solution; Or germanium concentration is the GeO of 50-1000 microgram/gram 2Solution or zinc concentration are the solution of zinc sulfate of 800-4000 microgram/gram etc.
Above-mentioned germinating cabinet can be the germinating cabinet of existing cultivation apparatus without soil, for example the cultivation case of lucifuge, cultivation box, germinating cabinet etc.
Zinc (Zn) plays immeasurable effect in life process, be described as " Promethean fire flower ".Many researchs point out that the effect of zinc and juvenile's height is most important, are to influence the excretory important element of human growth hormone.It directly acts on hypophysis cerebri, can reasonably activate, and adjusts secretion of growth hormone, synthetic and release, promote the human body metabolism, accelerate cell division and regeneration, make the regeneration of shank skeletal cartilage, carrtilage space increases, manyly absorb skeleton nutrition quickly, reach the purpose that increases.Even under the situation that cartilage has healed, secretion that still can the stimulating growth hormone makes brain skeletal cartilage regeneration slit, absorbs nutrition once more, reaches the effect that increases once more.Zinc has many-sided physiological function, zinc deficiency will influence that the metabolism that the proper splitting of cell and immune function depression, protein synthesis produce obstacle, endocrine disturbance, cell slows down, resistance weakens, individual senescence process is accelerated, and can be caused cancer morbidity to increase.
L-lysine is one of proteinic important component part, it is the indispensable food additive of human body, be referred to as meaning " aminoacid that nutrition is necessary " by scientist, it can health invigorating, promote intelligence development, increase child's height, but and vessel softening, preventing multiple functions such as cerebral hemorrhage, is the nutrition treasure that the world today generally acknowledges.
Diabetes patient's organic state micro element supplement agent of the present invention is composed as follows:
Contain 1 part of chromium Semen Glycines powder
Contain vanadium Semen Glycines powder 0.8-3.2 part
Contain lithium Semen Glycines powder 5.3-10.7 part
Contain selenium Semen Glycines powder 6.7-26.7 part
Contain zinc Semen Glycines powder 22.2-33.3 part
This prescription is according to human body the daily requirement of mentioned component to be prepared.
The present invention uses contains chromium, contain vanadium, contain lithium, contain selenium, contain the zinc Semen Glycines powder, can obtain with the nutritional solution soaking beans kind, the accelerating germination that contain trace element chromium, vanadium, lithium, selenium, zinc by the method for soilless culture.The concrete preparation method that contains selenium, germanium Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water.
The used nutritional solution that contains trace element of seed soaking can be that selenium concentration is the Na of 50-100 microgram/gram in the first step 2SeO 3Solution etc.; Or germanium concentration is the GeO of 50-1000 microgram/gram 2Solution or zinc concentration are that solution of zinc sulfate of 600-4000 microgram/gram etc. or concentration are the CrCl of 50-1000ug/g 3Solution etc., or concentration is the lithium carbonate solution of 50-200ug/g etc., or concentration is sodium metavanadate, sodium vanadate solution of 50-500ug/g etc.Above-mentioned solution can be separately or two kinds of solution mix and use.
Above-mentioned various microelement nutritious liquid is self transformation by these bean kinds, closes with its intravital organic acid (as aminoacid) chromium, generates various organic chromium compounds---the active substance of life, promptly helps the trace element of absorption of human body and utilization.
Above-mentioned germinating cabinet can be the germinating cabinet of existing cultivation apparatus without soil, the cultivation case of routine good lucifuge, cultivation box, germinating cabinet etc.
Chromium (Cr 3+) be the active component of glucose tolerance factor, chromium exists with three valence states in vivo, and chromic main effect is the metabolism of involved in sugar and fat, and the chromic content of diabetics blood plasma is starkly lower than the normal person, and patient's blood glucose is reduced; To blood glucose person on the low side, blood glucose is risen.Trivalent chromium is harmless in vivo.
Lithium (Li) can promote various tissue picked-up sugar and store glycogen, humans and animals is all had antidiabetic effect.Treat the diabetes result of the test with lithium: 1. blood glucose, glucose in urine all reduce; 2. plasma insulin, C peptide concentration all descend; 3. the Insulin receptor INSR number of high and low affinity all increases on the erythrocyte, and lithium performance blood sugar reducing function is described.Result of study shows that also lithium can also promote the dna replication dna of insulin B cell.Lithium carbonate is one for the treatment of diabetes ancillary drug commonly used, and the adult is 200-400ug/d to the day requirement of lithium.
Vanadium (V) not only participates in human body hemopoietic in human body, also influence cholesterol metabolism.Recently studies show that vanadium has ILA, vanadate reduces the blood glucose value of rising.The blood sugar reducing function of vanadium is relevant with combined state, and the adult is 40ug/d to the daily requirement of vanadium.Confirm that at present sodium metavanadate, sodium vanadate, vanadium oxysulfate, five oxos, two vanadium etc. all have blood sugar reducing function.
The dependency that has height between diabetes and the selenium.Selenic metabolism disorder in the diabetics body.Selenium also is the active center material of glutathion peroxidase (GSH-Px).The relation of selenium and diabetes receives publicity recently.Recently selenic result of study is found: type ii diabetes does not have complication group and the no significant difference of health group contrast, and type ii diabetes has complication group and health to organize and do not have the contrast of complication group, and highly significant difference is all arranged.Prompting is to the suitable selenium supplement of type ii diabetes person that complication is arranged.
At present, known in human body have at least the activity of 80 plurality of enzymes all relevant with zinc.Enzyme is a biocatalyzer, because zinc energy kinase, so promote the metabolism of sugar.Pancreas is one of the most responsive organ of zinc metabolism, and insulin is that the form with crystalline state or subgrain attitude zinc is present in the secreting gland of pancreas.Lacking zinc is the major reason that insulin concentration reduces.Usually the content of zinc (Zn) is lower than the normal person among diabetes blood glucose's (or hair), illustrates that the diabetes patient needs zinc supplement.
The used beans of the present invention can be Semen Glycines, Semen phaseoli radiati, Semen sojae atricolor, Semen Phaseoli, Semen Pisi sativi, Seem Lablab Album etc.
Organic state micro element supplement agent of the present invention can be made dosage forms such as electuary, concentrated solution, capsule.
As seen organic trace nutrient supplement of the present invention mainly be among the current crowd often because of lacking trace nutrient in the food, can not satisfy the health needs and cause body immunity to descend, vulnerable, easy aging, easily fall ill and the new product released.It is divided into middle-aged and elderly people organic state micro element supplement agent, juvenile's organic state micro element supplement agent, diabetes patient's organic state micro element supplement agent according to different age people and nutritional deficiency disease situation.
Technical conceive of the present invention is an applying biological geochemistry food engineering scientific method, utilize above-mentioned various needed by human or beneficial trace elements optimize beans, improve little nutrient composition content level of these beans and be primary raw material, add an amount of vitamin E, VE etc. with these rich plain Semen Glycines powderes.By human body the daily requirement of various trace element is carried out scientific matching.
The adult is as follows to the daily requirement of trace element, vitamin: chromium 50-200ug/d; Lithium 200-400ug/d; Vanadium 40ug/d; Selenium 50-200ug/d; Germanium 0.4-3.5mg/d; Zinc 10-15mg/d; Vitamin E 50-150mg/d; Vitamin C 100-300mg/d; Lysine 1-2g/d (children).
The present invention compared with prior art has following advantage:
It is 1, used that base stock---containing trace element beans powder is the biological product of pure natural.The trace element that is rich in the beans is sheerly natural, the bioactive organic complex of tool.It is an applying biological geochemistry food engineering scientific method, utilize biological (beans) as the carrier that transmits micro elements needed by human, promptly, the trace element of artificial input is organised, become the active substance that is easy to the absorption of human body utilization by the transformation of beans self.
2, trace element lives through great several times improvement as the development and use of nutrient source for a long time substantially, promptly by the product that directly utilizes inorganic salt (as zinc sulfate etc.) to make.As (the belonging to first generation nutrient) such as " Centrum " of agent of sulfated compound zinc metal sheet and current market sale; With the product of simple organic acid and inorganic salt chemosynthesis, as (the belonging to second filial generation trace nutrient) such as zinc gluconate of current market sale; The product that utilizes biogenic aminoacid and trace element complexation (or chelating) to make belongs to third generation nutrient, also is the nutrient of latest generation.The latter overcomes poor, the instability of preceding two generation product bio-absorbable usability, easily oxidation, easily has between element shortcoming such as antagonism between the moisture absorption and inorganic salt product.
Organic state micro element supplement agent of the present invention is the third generation that belongs to above-mentioned, i.e. Xin Yidai product.Its advantage is the bioavailability that has improved trace element greatly, and anti-interference, good stability, toxicity are little, are the effective little nutrients of a kind of safety and stability.
3, the preparation of organic state micro element supplement agent of the present invention is the rapport that makes full use of between trace element, makes the bigger effect of they performances, as the rapport between trace element-selenium and the germanium; Rapport between rapport between trace element-selenium and the vitamin E and vitamin E and the vitamin C etc.And have only single vitamin E or its health product to sell (as oral capsule, skincare product etc.) or inorganic states trace element replenisher on the current market.Middle-aged and elderly people organic state micro element supplement agent of the present invention is exactly to make full use of the new product that trace element-selenium is used with cooperating of vitamin E and the rapport of selenium and germanium is developed; Also make full use of simultaneously and other nutritional labeling between rapport, as trace element zinc and L-lysine and macroelement calcium to the juvenile increase, intelligence development all is considerable nutrient substance, therefore, in juvenile's organic state micro element supplement agent of the present invention, all these nutrient substance are taken into account.
Also have in the diabetes medicament and health product of current market sale, utilize trace element few for medicine and health product that the diabetes patient uses specially, what have just makes an addition in the milk powder with Chlorizate chromium.Diabetes patient's organic state micro element supplement agent of the present invention is the cause effect relation at trace nutrient and diabetes, utilizes the trace element relevant with developing various diabetes more all sidedly.
Below by embodiment the present invention is done further narration.
Embodiment 1
The middle-aged and elderly people organic state micro element supplement agent
(1) contains selenium, the preparation of germanium Semen phaseoli radiati powder
The first step: (selenium concentration is the Na of 100 microgram/grams with " selenium-germanium " mixed solution 2SeO 3With germanium concentration be the GeO of 500 microgram/grams 2Solution) soaked mung bean seed 6 hours, make seed fully absorb nutritional solution to saturated;
Second step: first step seeds treated in the germinating cabinet under 25 ℃ of conditions accelerating germination 1 day become to contain the Semen phaseoli radiati kind bud of organic state micro element;
The 3rd step: gained Semen phaseoli radiati kind bud soaks, washes, dries, grinds to form Semen phaseoli radiati powder with ionized water.
Se content is that 40-60ug/g, Ge content are 400-600ug/g in the Semen phaseoli radiati powder.
(2) prescription: rich selenium-germanium Semen phaseoli radiati powder 20g; Vitamin e1 500mg; Vc3000mg.Make capsule, every capsules dress 0.6g.Allow 55 years old designed for old people, 4/day, 2 times/day, 2/time.1 month aftersensation mental status is preferable, do not have inflammation, indefatigability such as flu, vigor is arranged.
Embodiment 2
Juvenile's organic state micro element supplement agent
(1) preparation of rich zinc green Semen Glycines powder: with zinc concentration is the solution of zinc sulfate optimization Semen phaseoli radiati of 3000ug/g, obtains containing the analysis for soybean powder of zinc 2500ug/g.The preparation that contains selenium, germanium Semen phaseoli radiati powder is with embodiment 1.
(2) prescription is formed: rich zinc green Semen Glycines powder 20g; Rich selenium germanium Semen Glycines powder 10g; Vitamin E 500mg; Vitamin C 1000mg; L-lysine 10g.Make tablet, every 0.6g makes 10 years old juvenile edible, and 3 slices/time, 3 times/day; Obviously grow tall after 6 months, healthy, hypermnesia.
Embodiment 3
Diabetes patient's organic state micro element supplement agent
(1) contains chromium (Cr 3+), the preparation of lithium, vanadium, zinc and selenium Semen Glycines powder:
With chromium chloride solution (Cr 3+Concentration is 1000ug/g), lithium carbonate solution (Li concentration is 400ug/g), sodium metavanadate (V concentration is 200ug/g), sodium selenite (Se concentration is 75ug/g) and solution of zinc sulfate (Zn concentration is 4000ug/g) optimize the Semen Glycines seed respectively.Can obtain containing Cr 3+The analysis for soybean powder of 800ug/g, Li250ug/g, V100ug/g, Se50ug/g, Ge400ug/g, Zn3000ug/g.
(2) prescription is formed: contain chromium Semen Glycines powder 10g; Contain lithium Semen Glycines powder 10g; Contain vanadium Semen Glycines powder 2.5g; Contain zinc Semen Glycines powder 20g; Contain selenium, germanium Semen Glycines powder 10g.Make capsule, every 0.6g allows 60 years old diabetes patient, and 3/day, 3 times/day, 1/time.The state of an illness is alleviated after 1 month, and blood glucose reduces.

Claims (2)

1, a kind of organic state micro element supplement agent is characterized in that main weight is composed as follows:
Contain selenium Semen Glycines powder 10-40 part
Germanic Semen Glycines powder 10-88 part
1 part of vitamin E
Vitamin C 1-3 part; The described preparation method that contains selenium, germanium Semen Glycines powder is as follows:
The first step: soaked seed 4-6 hour with the nutritional solution that contains trace element;
Second step: first step seeds treated became to contain the kind bud of organic state micro element in accelerating germination 1-2 days under 20-28 ℃ of condition in the germinating cabinet;
The 3rd step: gained kind bud soaks, washes, dries, pulverizes with ionized water; The used nutritional solution that contains trace element of seed soaking is that selenium concentration is the Na of 50-100 microgram/gram in the first step 2SeO 3Solution, or germanium concentration is the GeO of 50-1000 microgram/gram 2Solution; Described bean kind is Semen Glycines, Semen phaseoli radiati, Semen sojae atricolor, Semen Phaseoli, Semen Pisi sativi or Seem Lablab Album.
2, organic state micro element supplement agent according to claim 1 is characterized in that its weight composition also comprises:
Contain zinc Semen Glycines powder 30-50 part
L-lysine 10-20 part; The used nutritional solution that contains trace element of first step seed soaking comprises that also zinc concentration is the solution of zinc sulfate of 800-4000 microgram/gram.
CN99124691A 1999-07-20 1999-12-30 Organic trace elements supplement Expired - Fee Related CN1112214C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN99124691A CN1112214C (en) 1999-12-30 1999-12-30 Organic trace elements supplement
US09/795,406 US6505439B2 (en) 1999-07-20 2001-02-28 Process for producing natural organic trace element rich nutritional supplements

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CN109430885A (en) * 2018-12-27 2019-03-08 陈莉 It is a kind of using oligopeptide as nutritional agents of carrier and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1194141A (en) * 1997-03-26 1998-09-30 张星辰 Phospholipid hard capsule

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1194141A (en) * 1997-03-26 1998-09-30 张星辰 Phospholipid hard capsule

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