CN109430885A - It is a kind of using oligopeptide as nutritional agents of carrier and preparation method thereof - Google Patents
It is a kind of using oligopeptide as nutritional agents of carrier and preparation method thereof Download PDFInfo
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- CN109430885A CN109430885A CN201811609441.6A CN201811609441A CN109430885A CN 109430885 A CN109430885 A CN 109430885A CN 201811609441 A CN201811609441 A CN 201811609441A CN 109430885 A CN109430885 A CN 109430885A
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- oligopeptide
- pulvis
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- capsule body
- carrier
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- 108010038807 Oligopeptides Proteins 0.000 title claims abstract description 74
- 102000015636 Oligopeptides Human genes 0.000 title claims abstract description 74
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000002775 capsule Substances 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 28
- 230000035764 nutrition Effects 0.000 claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 238000011049 filling Methods 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims abstract description 17
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 17
- 239000011651 chromium Substances 0.000 claims abstract description 17
- 229910052804 chromium Inorganic materials 0.000 claims abstract description 17
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims abstract description 17
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000011159 matrix material Substances 0.000 claims abstract description 16
- 239000011669 selenium Substances 0.000 claims abstract description 16
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 16
- 102000008186 Collagen Human genes 0.000 claims description 25
- 108010035532 Collagen Proteins 0.000 claims description 25
- 210000000988 bone and bone Anatomy 0.000 claims description 25
- 229920001436 collagen Polymers 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- 244000068988 Glycine max Species 0.000 claims description 12
- 235000010469 Glycine max Nutrition 0.000 claims description 12
- 229920001817 Agar Polymers 0.000 claims description 10
- 241000196324 Embryophyta Species 0.000 claims description 10
- 229920002774 Maltodextrin Polymers 0.000 claims description 10
- 239000005913 Maltodextrin Substances 0.000 claims description 10
- 241000276701 Oreochromis mossambicus Species 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 238000005189 flocculation Methods 0.000 claims description 10
- 230000016615 flocculation Effects 0.000 claims description 10
- 229940035034 maltodextrin Drugs 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- 239000008107 starch Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 241000251468 Actinopterygii Species 0.000 claims description 9
- 230000007071 enzymatic hydrolysis Effects 0.000 claims description 7
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims description 7
- 241000251511 Holothuroidea Species 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 5
- 241000237502 Ostreidae Species 0.000 claims description 5
- 238000010612 desalination reaction Methods 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000005342 ion exchange Methods 0.000 claims description 5
- 235000020636 oyster Nutrition 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 2
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 14
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 7
- 239000011573 trace mineral Substances 0.000 abstract description 6
- 235000013619 trace mineral Nutrition 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 5
- 230000023852 carbohydrate metabolic process Effects 0.000 abstract description 4
- 230000004203 pancreatic function Effects 0.000 abstract description 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 8
- 241000758789 Juglans Species 0.000 description 4
- 235000009496 Juglans regia Nutrition 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000020234 walnut Nutrition 0.000 description 4
- 244000046052 Phaseolus vulgaris Species 0.000 description 3
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 208000033065 inborn errors of immunity Diseases 0.000 description 3
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 206010018473 Glycosuria Diseases 0.000 description 1
- 206010039921 Selenium deficiency Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of oligopeptide nutritional agents and preparation method thereof, it include: capsule body raw material and filling pulvis, the filling pulvis includes matrix pulvis and nutrition powder, described matrix pulvis is made of oligomeric Gly-His-Lys, the nutrition powder is counted by ratio of weight and the number of copies, including following components: organism organic selenium: 5-25 parts, biological organic chromium: 1-5 parts, VC:50 parts, matrix pulvis and nutrition powder in the filling pulvis are 1:100 by weight, it is a kind of using oligopeptide as the preparation method of the nutritional agents of carrier, capsule body raw material is obtained into class capsule body, nutrition powder is filled in class capsule body, sugar tolerance ability is improved using oligopeptide, promote the absorption of microelement, keep human body more accurate to the absorption of trace elements time using oligomeric peptides capsule body, it can more effective supplemented with exogenous biological organic Selenium and biological organic chromium improve pancreas function, promote glycometabolism normal, enhance patient's immunity of organisms, prevent complication and tumour occurs.
Description
Technical field
It is the present invention relates to a kind of medical preparation field, in particular to a kind of using oligopeptide as the nutritional agents of carrier and its preparation
Method.
Background technique
Due to the factors such as environment, diet influence, tumor incidence is higher and higher, in oncotherapy, at present in addition to
Operation.Chemicotherapy, it is upper without more perfect technological means, using exogenous element rationally solve tumour patient hypoimmunity and
The problem of internal trace elements of selenium shortcoming, reaches raising and improves immune function, and treatment occurs swollen because lacking trace elements of selenium
Tumor disease is reported according to the world cancer village and is estimated, estimates China's cancer new cases 429.2 ten thousand in 2015, death toll 281.4 ten thousand
People accounts for about a quarter of global number of cancer deaths, and China just has 8.3 people to suffer from pain per minute, and 5.2 people die of cancer and build, exempt from
Epidemic disease power is low and body trace element selenium deficiency is the main common trait of tumour patient, current research China 18 years old as the result is shown
Or more in adult, the diabetes estimation illness rate diagnosed according to international newest clinical criteria is 1.6%, new to issue
Diabetes mellitus in China disease incidence account for the one third of global diabetes number, analyzed according to pathological study, hypoimmunity and body
Microelement chromium deficiency is the main common trait of diabetes patient, and the therapeutic agent of diabetes is various, and many drugs, which all exist, to be produced
Weight toxic side effect generates certain influence to patient's liver kidney.Therapeutic effect is also unsatisfactory, is rationally solved using exogenous microelement
Certainly glycosuria people hypoimmunity and internal trace element chromium shortcoming problem, reach raising and improve immune function, prevent and treat micro- because lacking
Secondary element chromium and the diabetes occurred.
Oligopeptide is the important component of body cell, tissue, organ tectine, due to endogenous deficiency, leads to that disease occurs
Disease and aging, timely and appropriate discovery are supplemented by external source, meet the needs of body eubolism, thus realize the healthy state for restoring body,
Oligopeptide has high-purity, high-energy, high bioactivity, improves sugar tolerance ability, can promote absorption of the human body to nutriment.
Summary of the invention
The present invention be directed to tumour and diabetic population body feature and existing physiological status, utilize exogenous micro member
It is plain rationally to solve the problems, such as immunity degradation and internal microelement shortcoming, reach raising and improve immune function, prevents and treats micro- because lacking
Secondary element and suffer from tumour and diabetes, the present invention utilize oligopeptide, promote the absorption of microelement, utilize oligomeric peptides capsule body
Keep human body more accurate to the absorption of trace elements time, energy more effectively supplemented with exogenous organism organic selenium and biological organic chromium change
Kind pancreas function, promotes glycometabolism normal, enhances patient's immunity of organisms, prevents complication and tumour occurs.
Technical solution provided by the invention are as follows:
It is a kind of using oligopeptide as the nutritional agents of carrier characterized by comprising capsule body raw material and filling pulvis, it is described
Filling pulvis includes matrix pulvis and nutrition powder, and described matrix pulvis is made of oligomeric Gly-His-Lys, and the nutrition powder is by weight
Portion rate meter, including following components: organism organic selenium: 5-25 parts, biological organic chromium: 1-5 parts, VC:50 parts, the filling pulvis
In matrix pulvis and nutrition powder be by weight 1:100；
The capsule body raw material is by weight percentage, composed of the following components: 40% maltodextrin, 30% oligopeptide
Powder, 10% hydroxypropul starch, 20% agaropectin.
Preferably, the nutrition powder is counted by ratio of weight and the number of copies, including following components: organism organic selenium: 5 parts, biology
Organic Chromium: 1 part, VC:50 parts.
Preferably, the nutrition powder is counted by ratio of weight and the number of copies, including following components: organism organic selenium: 25 parts, biology
Organic Chromium: 5 parts, VC:50 parts.
Preferably, the oligomeric Gly-His-Lys be fish scale, bone, the collagen oligopeptide of skin, ox bone collagen albumen oligopeptide,
One or both of plants oligopeptide such as sea cucumber oligopeptide, oyster oligopeptide or soybean, walnut, the animal collagen
Oligopeptide or plant collagen oligopeptide average molecular weight are respectively less than 1000 dalton.
Preferably, the soybean oligopeptide the preparation method comprises the following steps: by soybean successively by crushing, Protein Separation, enzymatic hydrolysis,
Concentration, decoloration and drying.
Preferably, the fish scale, bone, collagen oligopeptide are using ocean Tilapia mossambica fish scale, bone, skin as primary raw material
Ocean Tilapia mossambica fish scale, bone, skin is dry by drying, crushing, dissolution, enzymatic hydrolysis, filtering, desalination, decoloration, ion exchange and concentration
It is dry to be made.
It is a kind of to include the following steps using oligopeptide as the preparation method of the nutritional agents of carrier,
Step 1: it is obtained after maltodextrin, hydroxypropul starch and agaropectin in capsule body raw material are mixed by both certainty ratios
Composition A,
Step 2: above-mentioned composition A is heated to 80 DEG C by the water that volume is added 4-6 times, the time of heating is 15 minutes
~90, it is allowed to be gelatinized gelatinization,
Step 3: the oligomeric Gly-His-Lys of both certainty ratios will be added in mixture that step 2 obtains, stirs evenly.
Step 4: will be added flocculation aid in the resulting mixture of step 3, stir evenly, and the flocculation aid is potassium carbonate.
Step 5: the mixture that step 4 is obtained is put into capsule draft machine, and spray drying obtains class capsule body.
Step 6: filling pulvis is filled in class capsule body.
The beneficial effects of the present invention are embodied in the followings:
1: improving sugar tolerance ability using oligopeptide, promote the absorption of microelement.
2: using oligomeric peptides capsule body extend human body to the soak time of nutrition powder enable oligopeptide with it is micro
Element enters the absorption site of small intestine together, forms supported ionic, promotes the suction of exogenous organism organic selenium and biological organic chromium
It receives.
3: improving pancreas function, promote glycometabolism normal, enhance patient's immunity of organisms, prevent complication and tumour hair
It is raw.
Specific embodiment
The present invention is described in further detail below, to enable those skilled in the art's refer to the instruction text being capable of evidence
To implement.
Embodiment 1
It is a kind of using oligopeptide as the nutritional agents of carrier, comprising: capsule body raw material and filling pulvis, the filling pulvis includes
Matrix pulvis and nutrition powder, described matrix pulvis are made of oligomeric Gly-His-Lys, and the nutrition powder is counted by ratio of weight and the number of copies, including
Following components: organism organic selenium: 5 parts, biological organic chromium: 1 part, VC:50 parts, the matrix pulvis filled in pulvis and nutrition
Pulvis is 1:100 by weight；
The capsule body raw material is by weight percentage, composed of the following components: 40% maltodextrin, 30% oligopeptide
Powder, 10% hydroxypropul starch, 20% agaropectin.
The oligomeric Gly-His-Lys are that fish scale, bone, the collagen oligopeptide of skin, ox bone collagen albumen oligopeptide, sea cucumber are oligomeric
One or both of plants oligopeptide such as peptide, oyster oligopeptide or soybean, walnut, the animal collagen oligopeptide or
Plant collagen oligopeptide average molecular weight is respectively less than 1000 dalton, the soybean oligopeptide the preparation method comprises the following steps: by big
Beans are successively by crushing, Protein Separation, enzymatic hydrolysis, concentration, decoloration and drying, and the fish scale, bone, collagen oligopeptide are with sea
Ocean Tilapia mossambica fish scale, bone, skin are passed through dry, crushing for primary raw material, dissolution, digested, mistake by foreign Tilapia mossambica fish scale, bone, skin
Filter, desalination, decoloration, ion exchange and concentrate drying are made.
It is a kind of to include the following steps using oligopeptide as the preparation method of the nutritional agents of carrier,
Step 1: it is obtained after maltodextrin, hydroxypropul starch and agaropectin in capsule body raw material are mixed by both certainty ratios
Composition A,
Step 2: above-mentioned composition A is heated to 80 DEG C by the water that volume is added 4-6 times, the time of heating is 15 minutes
~90, it is allowed to be gelatinized gelatinization,
Step 3: the oligomeric Gly-His-Lys of both certainty ratios will be added in mixture that step 2 obtains, stirs evenly.
Step 4: will be added flocculation aid in the resulting mixture of step 3, stir evenly, and the flocculation aid is potassium carbonate.
Step 5: the mixture that step 4 is obtained is put into capsule draft machine, and spray drying obtains class capsule body.
Step 6: filling pulvis is filled in class capsule body.
Embodiment 2
8, a kind of using oligopeptide as the nutritional agents of carrier characterized by comprising capsule body raw material and filling pulvis, institute
Stating filling pulvis includes matrix pulvis and nutrition powder, and described matrix pulvis is made of oligomeric Gly-His-Lys, and the nutrition powder is by weight
Measure portion rate meter, including following components: the nutrition powder is counted by ratio of weight and the number of copies, including following components: organism organic selenium: 25
Part, biological organic chromium: 5 parts, VC:50 parts；
The capsule body raw material is by weight percentage, composed of the following components: 40% maltodextrin, 30% oligopeptide
Powder, 10% hydroxypropul starch, 20% agaropectin.
The oligomeric Gly-His-Lys are that fish scale, bone, the collagen oligopeptide of skin, ox bone collagen albumen oligopeptide, sea cucumber are oligomeric
One or both of plants oligopeptide such as peptide, oyster oligopeptide or soybean, walnut, the animal collagen oligopeptide or
Plant collagen oligopeptide average molecular weight is respectively less than 1000 dalton, the soybean oligopeptide the preparation method comprises the following steps: by big
Beans are successively by crushing, Protein Separation, enzymatic hydrolysis, concentration, decoloration and drying, and the fish scale, bone, collagen oligopeptide are with sea
Ocean Tilapia mossambica fish scale, bone, skin are passed through dry, crushing for primary raw material, dissolution, digested, mistake by foreign Tilapia mossambica fish scale, bone, skin
Filter, desalination, decoloration, ion exchange and concentrate drying are made.
It is a kind of to include the following steps using oligopeptide as the preparation method of the nutritional agents of carrier,
Step 1: it is obtained after maltodextrin, hydroxypropul starch and agaropectin in capsule body raw material are mixed by both certainty ratios
Composition A,
Step 2: above-mentioned composition A is heated to 80 DEG C by the water that volume is added 4-6 times, the time of heating is 15 minutes
~90, it is allowed to be gelatinized gelatinization,
Step 3: the oligomeric Gly-His-Lys of both certainty ratios will be added in mixture that step 2 obtains, stirs evenly.
Step 4: will be added flocculation aid in the resulting mixture of step 3, stir evenly, and the flocculation aid is potassium carbonate.
Step 5: the mixture that step 4 is obtained is put into capsule draft machine, and spray drying obtains class capsule body.
Step 6: filling pulvis is filled in class capsule body.
Embodiment 3
9, a kind of using oligopeptide as the nutritional agents of carrier characterized by comprising capsule body raw material and filling pulvis, institute
Stating filling pulvis includes matrix pulvis and nutrition powder, and described matrix pulvis is made of oligomeric Gly-His-Lys, and the nutrition powder is by weight
Measure portion rate meter, including following components: the nutrition powder is counted by ratio of weight and the number of copies, including following components: organism organic selenium: 25
Part, biological organic chromium: 5 parts, VC:50 parts；
The capsule body raw material is by weight percentage, composed of the following components: 40% maltodextrin, 30% oligopeptide
Powder, 10% hydroxypropul starch, 20% agaropectin.
The oligomeric Gly-His-Lys are that fish scale, bone, the collagen oligopeptide of skin, ox bone collagen albumen oligopeptide, sea cucumber are oligomeric
One or both of plants oligopeptide such as peptide, oyster oligopeptide or soybean, walnut, the animal collagen oligopeptide or
Plant collagen oligopeptide average molecular weight is respectively less than 1000 dalton, the soybean oligopeptide the preparation method comprises the following steps: by big
Beans are successively by crushing, Protein Separation, enzymatic hydrolysis, concentration, decoloration and drying, and the fish scale, bone, collagen oligopeptide are with sea
Ocean Tilapia mossambica fish scale, bone, skin are passed through dry, crushing for primary raw material, dissolution, digested, mistake by foreign Tilapia mossambica fish scale, bone, skin
Filter, desalination, decoloration, ion exchange and concentrate drying are made.
It is a kind of to include the following steps using oligopeptide as the preparation method of the nutritional agents of carrier,
Step 1: it is obtained after maltodextrin, hydroxypropul starch and agaropectin in capsule body raw material are mixed by both certainty ratios
Composition A,
Step 2: above-mentioned composition A is heated to 80 DEG C by the water that volume is added 4-6 times, the time of heating is 15 minutes
~90, it is allowed to be gelatinized gelatinization,
Step 3: the oligomeric Gly-His-Lys of both certainty ratios will be added in mixture that step 2 obtains, stirs evenly.
Step 4: will be added flocculation aid in the resulting mixture of step 3, stir evenly, and the flocculation aid is potassium carbonate.
Step 5: the mixture that step 4 is obtained is put into capsule draft machine, and spray drying obtains class capsule body.
Step 6: filling pulvis is filled in class capsule body.
The beneficial effects of the present invention are embodied in the followings:
1: improving sugar tolerance ability using oligopeptide, promote the absorption of microelement.
2: using oligomeric peptides capsule body extend human body to the soak time of nutrition powder enable oligopeptide with it is micro
Element enters the absorption site of small intestine together, forms supported ionic, promotes the suction of exogenous organism organic selenium and biological organic chromium
It receives.
3: improving pancreas function, promote glycometabolism normal, enhance patient's immunity of organisms, prevent complication and tumour hair
It is raw.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With.It can be applied to various suitable the field of the invention completely.It for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (7)
1. a kind of using oligopeptide as the nutritional agents of carrier characterized by comprising capsule body raw material and filling pulvis, it is described to fill out
Filling pulvis includes matrix pulvis and nutrition powder, and described matrix pulvis is made of oligomeric Gly-His-Lys, and the nutrition powder is by weight
Number is than meter, including following components: organism organic selenium: 5-25 parts, biological organic chromium: 1-5 parts, VC:50 parts, in the filling pulvis
Matrix pulvis and nutrition powder be by weight 1:100；
The capsule body raw material is by weight percentage, composed of the following components: 40% maltodextrin, 30% oligomeric Gly-His-Lys,
10% hydroxypropul starch, 20% agaropectin.
2. according to claim 1 a kind of using oligopeptide as the nutritional agents of carrier, which is characterized in that the nutrition powder is pressed
Weight fraction ratio meter, including following components: organism organic selenium: 5 parts, biological organic chromium: 1 part, VC:50 parts.
3. according to claim 1 a kind of using oligopeptide as the nutritional agents of carrier, which is characterized in that the nutrition powder is pressed
Weight fraction ratio meter, including following components: organism organic selenium: 25 parts, biological organic chromium: 5 parts, VC:50 parts.
4. according to claim 1 a kind of using oligopeptide as the nutritional agents of carrier, which is characterized in that the oligomeric Gly-His-Lys are
Fish scale, bone, the collagen oligopeptide of skin, ox bone collagen albumen oligopeptide, sea cucumber oligopeptide, oyster oligopeptide or soybean, core
One or both of plants oligopeptide such as peach, the animal collagen oligopeptide or plant collagen oligopeptide average mark
Son amount is respectively less than 1000 dalton.
5. according to claim 4 a kind of using oligopeptide as the nutritional agents of carrier, which is characterized in that the soybean oligopeptide
The preparation method comprises the following steps: by soybean successively by crushing, Protein Separation, enzymatic hydrolysis, concentration, decoloration and drying.
6. according to claim 4 a kind of using oligopeptide as the nutritional agents of carrier, which is characterized in that the fish scale, bone, skin
Collagen oligopeptide using ocean Tilapia mossambica fish scale, bone, skin as primary raw material by ocean Tilapia mossambica fish scale, bone, skin by it is dry,
Crushing, dissolution, enzymatic hydrolysis, filtering, desalination, decoloration, ion exchange and concentrate drying are made.
7. a kind of described in -6 according to claim 1 include the following steps using oligopeptide as the preparation method of the nutritional agents of carrier,
Step 1: it is combined after maltodextrin, hydroxypropul starch and agaropectin in capsule body raw material are mixed by both certainty ratios
Object A,
Step 2: being heated to 80 DEG C by the water that volume is added 4-6 times for above-mentioned composition A, and the time of heating is 15 minutes~90,
It is allowed to be gelatinized gelatinization,
Step 3: the oligomeric Gly-His-Lys of both certainty ratios will be added in mixture that step 2 obtains, stirs evenly.
Step 4: will be added flocculation aid in the resulting mixture of step 3, stir evenly, and the flocculation aid is potassium carbonate.
Step 5: the mixture that step 4 is obtained is put into capsule draft machine, and spray drying obtains class capsule body.
Step 6: filling pulvis is filled in class capsule body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN112494453A (en) * | 2020-12-30 | 2021-03-16 | 山东农业大学 | Agar/maltodextrin slow-release capsule and preparation method thereof |
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