CN101322559A - Multifunctional high-efficient calcium replenishing agent and preparation thereof - Google Patents
Multifunctional high-efficient calcium replenishing agent and preparation thereof Download PDFInfo
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- CN101322559A CN101322559A CNA2008101321127A CN200810132112A CN101322559A CN 101322559 A CN101322559 A CN 101322559A CN A2008101321127 A CNA2008101321127 A CN A2008101321127A CN 200810132112 A CN200810132112 A CN 200810132112A CN 101322559 A CN101322559 A CN 101322559A
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Abstract
The invention relates to a nutrient supplement for calcium supplementation, in particular to a multi-functional high-efficient calcium supplemental agent and a preparation method thereof which belong to the field of nutritious and health care products. The product of the invention selects inorganic calcium salt, L-ascorbic acid, L-aspartic acid for carrying out the reaction to prepare L-ascorbic acid-L-aspartic acid calcium; and the L-ascorbic acid-L-aspartic acid calcium can be prepared into health care foods with different forms such as tablets, granules, capsules, oral liquor and other after being added with necessary excipients. The product has good taste, no bitter taste and no gastrointestinal tract stimulation; the product has easy absorption, good safety and multiple nutritious health care functions. The product can more easily enter various parts of the human body through the passive diffusion, the transport or active transport and other different modes when in lack of calcium of the human body particularly, thereby meeting the needs on the calcium element by various tissues of the human body.
Description
Technical field
The present invention relates to a kind of nutrient prime replenisher that is used to replenish the calcium, particularly a kind of multifunctional high-efficient calcium replenishing agent and preparation method thereof, belong to the nutrition and health care field of food.
Background technology
Calcium is basis of human life, also is the abundantest mineral element of content in the human body, participates in whole life process, and multiple disease is all relevant with calcium deficiency.Calcium constituent can only be taken in from " drink " and " food " by people, and the national calcium deficiency of China is indubitable at present, and China repeatedly nutrition survey result proves that all calcium is the nutrient that lacks most.It is necessary conscientiously that Chinese people China Association for Promoting Democracy row generally, is reasonably replenished the calcium.But disease that many calcium deficiency cause and symptom have been used after the calcium agent, and effect is unsatisfactory.Safety, efficient, the economy development and the production of practical calcium nutritional supplement have again become China nutrition educational circles, the numerous scientific workers' of food educational circles important topic.
China's calcium deficiency for the entire people is familiar with by people gradually, and calcium tonic enlarges to nutritional health food from medicine company.At present, replenishing the calcium exists a kind of mistaken ideas, and that is exactly vitamin D Can and phosphorus when replenishing the calcium, and emphasizes certain calcium-phosphorus ratio, but body generally should not lack phosphorus and V
D, cause V on the contrary easily
DPoison, and cause abnormal calcium metabolism.Calcium agent on current market mainly contains three types of inorganic calcium, BIOLOGICAL CALCIUM and organic calciums.The calcium agent that is used the earliest is an inorganic calcium, and as calcium carbonate, calcium oxide, calcium hydroxide, calcium phosphate etc., the characteristics of inorganic calcium are that preparation is simple, cheap and easy to get, but exist following shortcoming: (1) calcium exists with the inorganic ions form, is difficult to be absorbed by the body, and bioavailability is low; (2) inorganic calcium, bitter and puckery flavor will consume a large amount of hydrochloric acid in gastric juice after taking, and stomach is had spread effect; (3) facile hydrolysis in enteron aisle is easy to CO
3 2-, PO
4 3-, generation indissoluble thing such as phytic acid and influence absorption.In order to improve the absorption rate of calcium, people have developed second generation organic calcium supplement, as calcium gluconae, calcium lactate, calcium acetate, calcium citrate etc.These calcium agent are compared with inorganic calcium, and moral character has had bigger improvement, but still desirable not to the utmost.Calcium content as calcium gluconae is lower, and price is higher, and the user is difficult to accept.The acid group of some organic calcium salt is put aside in vivo and can be produced ill-effect, and the glucose acid group is decomposed into glucose, to not only calcium deficiency but also there is the glycosuria of suffering from patient unfavorable; That lactate can cause is weak, sense of fatigue etc., and it is unfavorable that people such as sportsman are replenished the calcium; It is bigger that calcium acetate exists acute toxicity, cause kidney stone and myocardium spasm easily and cause death, acetate also has the uncertain problem of other arguements, to make peculiar smell big for calcium acetate simultaneously, and direct labor and environment are had a negative impact.Calcium citrate is slightly soluble in water, and its application is restricted.The third generation of the up-to-date development hardening agent of replenishing the calcium is the amino acid complex of calcium, and the most representative is exactly calcium glycine, be characterized in almost having eliminated the peculiar acid of calcium salt, astringent taste, but price is higher, and is insoluble in water, and its application also is restricted.The amino-acid calcium that general amino acid and calcium reaction obtain is water insoluble or is insoluble in the material of water, effect of supplemented calcium is reduced.In addition,, find that lead content exceeds standard in most of calcium health products, have problems such as security hidden danger according to the sampling observation of national quality supervision and inspection department.
Summary of the invention
Is must propose such problem as a scientific worker: which type of calcium source only real good calcium source in the face of stern reality like this? how to make replenish the calcium more effective? how to solve in the calcium lead content safety issue such as exceed standard?
The inventor is in line with pragmatic principle, the long-pending research experience and the practice of this area for many years finds that under study for action a kind of good calcium complement agent should have following characteristics: (1) has left-handed structure, just have and to be discerned by biomembrane, optically active compound structure arranged; (2) molecular weight is moderate, have moderate fat-soluble, to guarantee permeates cell membranes with comparalive ease; (3) better water solubility is arranged, this is that calcium can be in the prerequisite of intestinal absorption; (4) have chelating or chelation structure, have moderate complexation constant, be not subject to the interference that some can form the material of insoluble chemical compound such as phosphoric acid, phytic acid with calcium ion, can discharge calcium ion lentamente in the place that needs calcium ion to guarantee calcium ion; (5) have the active transport mechanism of absorption, acid ion has biological health and trophic function.That is to say that desirable oral calcium tonic should meet easy absorption, moderate cost; No bitter taste, mouthfeel is good; Basic standard requirements such as no GI irritation.
Purpose of the present invention just provides a kind of multifunctional high-efficient calcium replenishing agent that meets These characteristics and standard-required and preparation method thereof.
The inventor is through years of researches and test, mechanism from absorption of human body element calcium, in line with practical, the research attitude of scientific and precise, to various calcium tonics analyze repeatedly, experiment sieving, learn from other's strong points to offset one's weaknesses, have complementary advantages, find L-ascorbic acid-this good calcium of L-calcium aspartate source, looked into new proof through the Scientific and Technical Information Institute and belong to domestic and international novel calcium tonic, finished the present invention finally.
Technical scheme of the present invention is achieved in that selects inorganic calcium salt and L-ascorbic acid for use, the L-aspartic acid is according to certain molar ratio, under suitable temperature conditions, react a period of time, filter, oven dry, pulverize and promptly obtain white or lurid L-ascorbic acid-L-calcium aspartate, with L-ascorbic acid-L-calcium aspartate as the calcium source, after utilizing prior art to add required auxiliary material, can be made into tablet through processing, electuary, capsule, the health food of four kinds of different shapes of oral liquid, or make an addition in the food as nutrition fortifier and use, or use as bulk drug.As with L-ascorbic acid-L-calcium aspartate as the calcium source, add taurine and zinc and can be made into the children special-purpose replenishers; Add glycine, iron and vitamin E and can be made into special-purpose replenishers of women or the like.
Inorganic calcium salt of the present invention is meant one or more of calcium carbonate, oyster shell calcium, pearl powder, egg-shell meal, calcium oxide, calcium hydroxide, calcium activated etc., calcium activated more preferably, this is that the lead content of calcium activated is very low, less than 1ppm because calcium activated claims activated ionic calcium again; Lead content is generally less than 20ppm in other calcium salts; The mol ratio of L-ascorbic acid, L-aspartic acid 1: 0.1～10, more preferably 1: 4～6; The molal quantity sum of L-ascorbic acid and L-aspartic acid is 1.5～2.5: 1 with the ratio of the molal quantity of inorganic calcium salt, more preferably 2: 1; Reaction temperature is 20～100 ℃, and more preferably 50 ℃, the reaction time is 1～3 hour, more preferably reacts 1.5 hours.Required auxiliary material is meant some known raw materials commonly used in the prior aries such as starch, glucose, citric acid, sucrose, sweetener, excipient, essence, pigment.
Several components can be mutually promoted and be absorbed and have a synergistic function in L-ascorbic acid-L-calcium aspartate, if lack wherein a kind of, result of use can be had a greatly reduced quality, this also is the conclusion that the inventor obtains through long term studies and test, though be not strict in concrete raw material proportioning qualification, can reach best result of use according to disclosed proportioning among the present invention.
Advantage of the present invention and beneficial effect are:
L-ascorbic acid-L-calcium aspartate has following characteristics: (1) has left-handed structure, can be discerned by cell membrane, can carry out active transport at intestinal villi cell epithelium by special carrier protein calcium channel and absorb, and not need the participation of vitamin D; (2) better water solubility is arranged, solubility is in 21～40g/100ml water, and under the different condition of pH value 1～14 equal solubilized, this be an all ages and classes, the people of different acid concentrations provides stomach and intestinal absorption possible; (3) have chelating or chelation structure, have moderate complexation constant, be not subject to the interference that some can form the material such as the phosphoric acid of insoluble chemical compound with calcium ion, can discharge calcium ion lentamente in the place that needs calcium ion; (4) acid ion has nourishing healthy and physiological function.L-ascorbic acid-L-calcium aspartate can also replenish L-ascorbic acid and L-aspartic acid, and the three has synergistic function except can supplementing calcium element.As: the L-ascorbic acid can promote the biosynthesis of collagen, helps the healing of tissue wounds; Promote bone and dental growth, strengthen capillary intensity, avoid oozing phenomenon occurring around tooth and the bone; Promote the metabolism of tyrosine and tryptophan, quicken the deaminizating metabolism of albumen or peptide class; Improve the utilization of iron, calcium and folic acid; The L-ascorbic acid still is a kind of free radical scavenger, but skin whitening can increase the body stress ability etc. of environment to external world.The L-aspartic acid has the function of improving myocardium shrinkage function and strengthening liver; Can also reduce the amount of ammonia and carbon dioxide in the blood, the effect of removing rubbish in the body is arranged; Can prevent skin aging, and make aging skin moisturizing; Has the fatigue of elimination, the function that regains one's strength fast.This shows that L-ascorbic acid-L-calcium aspartate can really be realized the purpose of " replenish the calcium and add power ".In addition, the lead content in the product of the present invention is extremely low, and less than 0.15ppm, the price economy material benefit has the market development potential.
The present invention is described further below in conjunction with embodiment, is limitation of the present invention but should not be construed as.
The specific embodiment
Embodiment 1:
Take by weighing 53.2 gram L-aspartic acids and 17.6 gram L-ascorbic acid are dissolved in the 200ml water, water-bath is heated to 50 ℃ and makes it to dissolve fully, taking by weighing 18.5 gram calcium activateds more slowly joins in the mixed solution of L-ascorbic acid and L-aspartic acid, stirring reaction 1.5 hours, making precipitation separate out the back fully filters, refining drying and crushing obtains white L-ascorbic acid-L-aspartic acid calcium powder 76.6 grams, solubility in water is 31.7g/100ml, this product does not only have the astringent taste of calcium, and mouthfeel is fine, nonirritant.
Embodiment 2:
Take by weighing 66.5 gram L-aspartic acids and 176 gram L-ascorbic acid are dissolved in the 500ml water, water-bath is heated to 60 ℃ and makes it to dissolve fully, taking by weighing 80 gram oyster shell calciums more slowly joins in the mixed solution of L-ascorbic acid and L-aspartic acid, stirring reaction 3 hours, making precipitation separate out the back fully filters, refining drying and crushing obtains white L-ascorbic acid-L-aspartic acid calcium powder 260.5 grams, solubility in water is 23.2g/100ml, this product does not only have the astringent taste of calcium, and mouthfeel is fine, nonirritant.
Embodiment 3:
Take by weighing 133 gram L-aspartic acids and 176 gram L-ascorbic acid are dissolved in the 600ml water, water-bath is heated to 40 ℃ and makes it to dissolve fully, taking by weighing 74 gram calcium activateds more slowly joins in the mixed solution of L-ascorbic acid and L-aspartic acid, stirring reaction 2 hours, making precipitation separate out the back fully filters, refining drying and crushing obtains ivory buff L-ascorbic acid-L-aspartic acid calcium powder 313.7 grams, solubility in water is 39.4g/100ml, this product does not only have the astringent taste of calcium, and mouthfeel is fine, nonirritant.
Claims (9)
1. multifunctional high-efficient calcium replenishing agent and preparation method thereof, it is characterized in that it being to select for use inorganic calcium salt and L-ascorbic acid, L-aspartic acid according to certain molar ratio, react a period of time under suitable temperature conditions, filtration, oven dry, pulverizing promptly obtain white or lurid L-ascorbic acid-L-calcium aspartate.
2. a kind of multifunctional high-efficient calcium replenishing agent as claimed in claim 1 and preparation method thereof is characterized in that selected inorganic calcium salt is meant one or more of calcium carbonate, oyster shell calcium, pearl powder, egg-shell meal, calcium oxide, calcium hydroxide, calcium activated etc.
3. as claim 1,2 described a kind of multifunctional high-efficient calcium replenishing agents and preparation method thereof, it is characterized in that selected inorganic calcium salt is meant calcium activated.
4. a kind of multifunctional high-efficient calcium replenishing agent as claimed in claim 1 and preparation method thereof is characterized in that the mol ratio 1: 0.1～10 of L-ascorbic acid, L aspartic acid; The molal quantity sum of L-ascorbic acid and L-aspartic acid is 1.5～2.5: 1 with the ratio of the molal quantity of inorganic calcium salt.
5. a kind of multifunctional high-efficient calcium replenishing agent as claimed in claim 1 and preparation method thereof, the mol ratio that it is characterized in that L-ascorbic acid, L aspartic acid is 1: 4～6; The molal quantity sum of L-ascorbic acid and L-aspartic acid is 2: 1 with the ratio of the molal quantity of inorganic calcium salt.
6. a kind of multifunctional high-efficient calcium replenishing agent as claimed in claim 1 and preparation method thereof is characterized in that reaction temperature is 20～100 ℃, and the reaction time is 1～3 hour.
7. a kind of multifunctional high-efficient calcium replenishing agent as claimed in claim 1 and preparation method thereof is characterized in that reaction temperature is 50 ℃, and the reaction time is 1.5 hours.
8. as described a kind of multifunctional high-efficient calcium replenishing agent of claim 1～5 and preparation method thereof, it is characterized in that taking by weighing 53.2 gram L-aspartic acids and 17.6 gram L-ascorbic acid are dissolved in the 200ml water, water-bath is heated to 50 ℃ and makes it to dissolve fully, taking by weighing 18.5 gram calcium activateds more slowly joins in the mixed solution of L-ascorbic acid and L-aspartic acid, stirring reaction 1.5 hours, make precipitation separate out the back fully and filter, refining drying and crushing obtains white L-ascorbic acid-L-aspartic acid calcium powder.
9. a kind of multifunctional high-efficient calcium replenishing agent as claimed in claim 1 and preparation method thereof is characterized in that L-ascorbic acid-L-calcium aspartate adding taurine and zinc and can be made into the children special-purpose replenishers as the calcium source; Add glycine, iron and vitamin E and can be made into the special-purpose replenishers of women.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101321127A CN101322559B (en) | 2008-07-18 | 2008-07-18 | Multifunctional high-efficient calcium replenishing agent |
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| CN2008101321127A CN101322559B (en) | 2008-07-18 | 2008-07-18 | Multifunctional high-efficient calcium replenishing agent |
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| CN101322559A true CN101322559A (en) | 2008-12-17 |
| CN101322559B CN101322559B (en) | 2012-01-11 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102987404A (en) * | 2012-08-21 | 2013-03-27 | 苏州谷力生物科技有限公司 | Food additive for promoting calcium absorption |
| CN104224893A (en) * | 2013-06-11 | 2014-12-24 | 美邦国际有限公司 | Absorbable encapsulated calcium in hypromellose capsule |
| CN111663151A (en) * | 2020-04-24 | 2020-09-15 | 广西科学院 | Process for preparing high-purity calcium glycinate by electrochemical-complexation reaction technology |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1112418A (en) * | 1994-05-25 | 1995-11-29 | 广州医学院 | Preparing method of calcium ascorbate |
| CN1144533C (en) * | 1998-03-25 | 2004-04-07 | 广西大学 | Composite amino-acid calcium compensating agent and its producing method |
| CN100528933C (en) * | 2006-07-04 | 2009-08-19 | 北京联合大学 | Calcium polyaspartate and preparation method thereof |
-
2008
- 2008-07-18 CN CN2008101321127A patent/CN101322559B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102987404A (en) * | 2012-08-21 | 2013-03-27 | 苏州谷力生物科技有限公司 | Food additive for promoting calcium absorption |
| CN104224893A (en) * | 2013-06-11 | 2014-12-24 | 美邦国际有限公司 | Absorbable encapsulated calcium in hypromellose capsule |
| CN111663151A (en) * | 2020-04-24 | 2020-09-15 | 广西科学院 | Process for preparing high-purity calcium glycinate by electrochemical-complexation reaction technology |
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| CN101322559B (en) | 2012-01-11 |
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Owner name: LIAONING MEITIANJIA BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: LI WEIPING Effective date: 20150709 |
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Effective date of registration: 20150709 Address after: 114016 No. 618, Jianshe Avenue, Qianshan District, Liaoning, Anshan Patentee after: LIAONING MEITIANJIA BIOTECHNOLOGY CO., LTD. Address before: 050021 Hebei Province, Shijiazhuang city Yuhua District No. 262 South Main Street Sports Fujin building block B room 1-1101 Patentee before: Li Weiping |
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Granted publication date: 20120111 Termination date: 20210718 |