KR100561286B1 - Growth-promoting Composition Comprising Dried Yeast, Extracted Natural Substances and Nutrient Mixed Powder - Google Patents

Abstract

The present invention relates to a health functional composition that helps growth and development,

More specifically, the present invention provides a growth promoting composition comprising a dry yeast, natural extract powder, nutrient mixture powder and additives, wherein the dry yeast is 50 to 90% by weight relative to the total composition weight; The natural product extract powder is 1 to 25% by weight based on the total weight of the composition; The nutritional mixed powder is 4 to 25% by weight based on the total weight of the composition; And by providing the growth promoting composition, characterized in that the additive is contained in an amount of 5 to 15% by weight based on the total weight of the composition, the growth promoting composition having excellent taste and preference, but no biological side effects and excellent growth promoting effect The purpose is to provide.

Yeast, Growth Promotion, Natural Extract Powder

Description

Growth-promoting Composition Comprising Dried Yeast, Extracted Natural Substances and Nutrient Mixed Powder} Containing Dry Yeast, Natural Extract Powder and Nutritious Mixed Powder

1 is a graph showing the change in the length of the long bone according to the amount of yeast in Sprague-Dawley male rats.

Figure 2 is a graph showing the concentration of growth hormone in the blood according to the amount of yeast in Sprague-Dawley male rats.

Figure 3 is a graph showing the average growth rate (%) when administering the embodiments according to the present invention to the growing children.

The present invention relates to a growth promoting composition. More specifically, the present invention is a growth promoting composition comprising a dry yeast, natural product extraction powder, nutrient mixture powder and additives, wherein the dry yeast is 50 to 90% by weight relative to the total composition weight; The natural product extract powder is 1 to 25% by weight based on the total weight of the composition; The nutritional mixed powder is 4 to 25% by weight based on the total weight of the composition; And by providing the growth promoting composition, characterized in that the additive is contained in an amount of 5 to 12% by weight based on the total weight of the composition, the growth promoting composition having excellent taste and preference but no biological side effects and excellent growth promoting effect It is about.

People living in modern times are experiencing nutritional imbalances due to environmental pollution, poor diet, and lifestyle changes. Despite the dazzling developments of modern science and medicine, modern people do not maintain optimal health due to stress, severe environmental pollution (water quality, air, food pollution), and changes in diet, resulting from excessive competition in the commercial society. I can't. Among these, especially the change of diet is the most serious and direct problem because it is directly related to our health.

As the development of modern technology solves the absolute poverty caused by food production, people pay attention to how to eat more delicious foods and foods that can be eaten for a long time in addition to the primary function of foods that fill the hunger. As a result, along with the development of food additives, the development of instant foods and processed foods.

While these foods enhance our vision and taste, and further satisfy our desire for simple and long storage, the loss of micronutrients and the overuse of chemicals, colorants, and preservatives in our refining processes are our health. Serious damage was done. In other words, the ingestion of animal food and sugar due to the westernization of diet, and the ingestion of refined foods lacking micronutrients contributed to the development of adult diseases such as heart disease and diabetes as well as nutritional imbalance. Therefore, the value of food, which prefers only palatability and convenience, has been emphasized in terms of quality of food.

In particular, when looking at human growth, genetic effects are generally thought to have the greatest impact, but in reality it is only about 23%. The remaining 77% is determined by acquired influence, and research has shown that nutrition is 31%, exercise 20%, environment 16%, and other 10% (Kawada Aiyoshi, `` The Secret of Tallity ''. MIDI, 1st edition Reprinted June 9, 1997, issued June 13, 1997).

Therefore, in order to promote growth, it is necessary to reduce the intake of instant foods, balance nutrition, remove proper exercise and polluting environment, and nutrition balance is essential.

In order to achieve such a balance of nutrition, various health foods, that is, health supplements are emerging as a new target of interest. In other words, health functional foods are being developed with the objective of promoting health, preventing and treating diseases from the passive concept of simple foods that maintain our bodies. Therefore, various health supplements to promote growth have been developed.

Among these health foods, general health supplements containing various natural products are sold on the market. These are functional foods using natural ingredients known to be effective for growth, and are not consumed in a form that does not satisfy the taste or taste of consumers due to the unique properties of natural products, but also have the disadvantage of insufficient growth effects.

On the other hand, yeast is widely used as an additive in growth promoting foods.

Yeast is about 50% protein and is rich in B vitamins. Moreover, yeast contains 6 to 10% of chelated minerals, of which about 80% or more are absorbed. In particular, it is a rare source of chromium, the main component of GTF, and is widely recognized as a perfect source of zinc, which is not only excellent in selenium content but also a key to insulin activity. The cell wall, which accounts for about 20% of yeast, is composed of dietary fibre, which has high intestinal utilization. Especially, the cell wall is composed of the meeting of the extracellular wall and the glucan of the cell wall. Yeast improves nutritional imbalance, promotes and maintains health, and metabolizes metabolism. It is a nutritional source that improves function.

On the other hand, yeast is added to the existing growth promoting foods contain a small amount of yeast, there was a point that did not fully utilize the growth promoting effect by yeast.

Accordingly, the present invention is provided to more efficiently solve the problems of the prior art as described above,

An object of the present invention is a growth promoting composition comprising a dry yeast, natural extract powder, nutrient mixture powder and additives, wherein the dry yeast is 50 to 90% by weight relative to the total weight of the composition; The natural product extract powder is 1 to 25% by weight based on the total weight of the composition; The nutritional mixed powder is 4 to 25% by weight based on the total weight of the composition; And by providing the growth promoting composition, characterized in that the additive is contained in an amount of 5 to 15% by weight based on the total weight of the composition, the growth promoting composition having excellent taste and preference, but no biological side effects and excellent growth promoting effect To provide.

The above and other objects can be achieved by the present invention described below.

In order to achieve the above object, the growth promoting composition according to the present invention is a growth promoting composition comprising a dry yeast, natural product extraction powder, nutrient mixture powder and additives, wherein the dry yeast is based on the total composition weight It may be 50 to 90% by weight.

50 to 90% by weight of the dry yeast, based on the total weight of the composition; The natural product extract powder is 1 to 25% by weight based on the total weight of the composition; The nutrient mixed powder is 4 to 25% by weight based on the total weight of the composition; And 5 to 15% by weight based on the total weight of the additive composition.

The dry yeast may be selected from the group consisting of lactic acid yeast, vitamin yeast, brewer's yeast, baker's yeast, yeast extract and mixtures thereof.

The natural extract powder may be selected from powders including safflower seed, malt, Seokchangpo, earth and sand, bokbunja, baekbokyeong, sansa, sanjoin, crystal clear, Angelica, Astragalus, licorice, viburnum and mixtures thereof.

The nutrient mixture powder is green tea powder, whey calcium, seaweed calcium, shark cartilage powder, vitamin 11 kinds, mineral-containing raw materials 5 kinds, bilberry extract powder, spirulina, chlorella extract powder, pollen crushed powder, colostrum powder, casein phospho It may be selected from powders consisting of peptides, fructooligosaccharides, soybean peptides, egg yolk lecithin and mixtures thereof.

The additive may be selected from the group consisting of crystalline cellulose, cocoa powder, aspartame, milk chocolate powder, sucrose fatty acid ester, hydroxypropyl methyl cellulose and mixtures thereof.

It may be a tablet consisting of the growth promoting composition.

It may be a granule made of the growth promoting composition.

It may be a capsule consisting of the growth promoting composition.

Hereinafter, the present invention will be described in detail.

Dry yeast according to the present invention is selected from lactic acid yeast, vitamin yeast, brewer's yeast, baker's yeast, yeast extract and mixtures thereof.

The amount of dry yeast may be 50 to 90% by weight based on the total weight of the growth promotion composition. When it is contained below 50% by weight, the effect cannot be expected, and when added above 90% by weight, the nutritional balance is reduced.

Dry yeast extract according to the present invention is extracted by adding purified water or ethanol and concentrated to dry.

Natural product extraction powder according to the present invention is selected from powders comprising safflower seed, malt, Seokchangpo, earth and sand, bokbunja, baekbokyeong, hawthorn, sanjoin, crystallization, Angelica, Astragalus, licorice, viburnum and mixtures thereof.

The natural raw materials are extracted, concentrated, and then powdered or dried to be powdered and evenly mixed together, and then 1 to 25% by weight based on the total weight of the growth promoting composition is used. If the content is less than 1% by weight, the effect is difficult to expect, and when used more than 25% by weight, the nutritional balance is reduced and it is difficult to chew.

Flos Carthami is a drawing of a year-old herbaceous safflower belonging to the Asteraceae family, which enhances the function of bone tissue cells, promotes bone development, quickly repairs bone damage caused by fractures or sprains, and dense reticulum. It helps increase bone density, which is a measure of bone health. Safflower seed according to the present invention contains 25 to 35% by weight based on the total weight of the natural product extract powder.

Malt (麥芽, Hordei Germinatus) flavor as that the germination of the seed is put geotbori properties are evaluated. The stomach is fragile and cannot digest food. Malt must be roasted slightly black and then ground slightly. In addition, it is rich in vitamin B ₁ to prevent each disease, to strengthen the stomach, liver, kidney, lung, spleen, reduce cholesterol and help prevent constipation and adult diseases, and to help digestion by warming the spleen and intestines. Malt according to the present invention contains 15 to 25% by weight based on the total weight of the natural product extract powder.

Seokchangpo (石菖蒲) ( Acorus Gramineus Soland ) is a evergreen perennial herb attached to Cheonnam Province. The leaves here have a long knife shape and have a distinctive scent like a stinging nose. These fragrances work to strengthen the brain, improve memory, stabilize the mind, and soothe pain. And Seokchangpo is excellent at releasing the fatigue of the cranial nerve. Seokchangpo according to the present invention contains 10 to 15% by weight based on the total weight of the natural product extract powder.

Cuscuta Chinensis Lamark is a mature seed of the same-year-old parasitic herbaceous ginseng and sea larvae ginseng that belongs to the maestroaceae family, and has a protective effect on the kidneys and liver. Plays an important role in facilitation. In other words, the liver is an organ that stores blood, and the function of muscles is deeply related to exercise.When a person sleeps at night, the blood gathers into the liver, and when it is active during the day, it is sent to the organs and meridians that are active. It means to perform, and has the function of regulating blood flow. If liver blood is scarce, blood distributed throughout the body will not be able to supply enough to meet the needs of human physiology.

Therefore, only enough blood is needed to allow nutrients to penetrate the muscles, which makes each tissue and organ healthy and promotes growth and development. The growth function is to keep the jeong (精), to control the bone (骨), to control the growth and reproduction, to produce the bone marrow and communicate with the brain. In oriental medicine, the kidney is regarded as an organ that has innate functions, but the shape and tissues of the brain, skeleton, root vein, skin, muscle, hair, etc. gradually grow and become complete, so that the body can grow and develop only when the kidney is congested. will be. If the dysfunction of the kidneys, lack of nutrition in the brain, skeletal, root vein, skin, muscles, etc., can cause growth disorders due to lower hormone secretion. Earth and sand according to the present invention contains 10 to 15% by weight based on the total weight of the natural product extract powder.

Bokbunja (覆盆子, Rubus Coreanus Miquel ) is an immature fruit of the deciduous irrigation, which is a deciduous shrub belonging to the Rosaceae family, and acts on the pituitary gland to stimulate the secretion of growth hormone, and stabilizes the function of the five intestines. It keeps the growth and catches ligaments and muscles in the joints. Bokbunja according to the present invention contains 10 to 15% by weight based on the total weight of the natural product extract powder.

Baek- bok- ryeong (Poria cocos Wolf, Polypori umbellati Polyporaceae ) belongs to the fungi family and is a parasitic worm in Songsu-geun (松樹 根). This reinforces the digestive system to ensure that the nutrients are well absorbed, to stabilize the heart function to eliminate stress, and to get a good night's sleep according to the height of the sleep, eliminating the growth disorder due to sleep deprivation . Baekbokryeong according to the present invention contains 2 to 5% by weight based on the total weight of the natural product extract powder.

Mountain lion (山査 子, Crataegi Fructus ) is a deciduous arborescent tree of the family Rosaceae, whose fruit is medicinal. This mountain lion is delicious and sweet, and its temperature is warm. Health and digestive action, coronary artery disorders and angina pectoris, hypertension, hyperlipidemia is used. In particular, it promotes the secretion and digestion of gastric juice. Sansa according to the present invention contains 2 to 5% by weight based on the total weight of the natural product extract powder.

Sanjoin ( Chinese 仁 , Chinese Jujube ) is a sea buckthorn plant that is even, sweet and tasteless, has no poison, and can't sleep because the heart burns . ) Lowers, adds the intermittent (肝氣), strengthens the muscules (筋骨), vegan (肥 健), and cures the musculature. Sanjoin according to the present invention contains 0.5 to 1.5% by weight based on the total weight of the natural product powder.

Cassiae Semen (決 明子, Cassiae Semen ) has a clearing effect on the eyes are red, swollen, painful, cold or teary eyes are good. It is effective for constipation caused by agglomeration of fever or drying of the intestines. It lowers blood cholesterol and lowers blood pressure. According to the present invention, the deficiency includes 0.5 to 1.5% by weight based on the total weight of the natural product extract powder.

Angelicae Giganits Radix is sweet and spicy. It is warm in nature, releasing paralysis symptoms and bleeding caused by blood circulation disorders. It is also effective for anemia and malnutrition and improves blood circulation. It is good for the sick and healthy people, and it is used for pain relief, soothing, hemorrhoids, ripening, soothing, painfulness, ripening, tonic, diuresis, epilepsy, blood donation, toothache, tonic. Angelica according to the present invention contains 0.5 to 1.5% by weight based on the total weight of the natural product extract powder.

Astragali Radix (黄 효과) is effective in the cardiovascular system and strengthens the normal heart contraction, strengthening the heart weakened by addiction or fatigue. Astragalus is excellent in lowering blood pressure, which is due to the expansion of blood vessels and coronary arteries, which is characterized by a rapid drop in blood pressure and short duration. Astragalus according to the present invention contains 0.5 to 1.5% by weight based on the total weight of the natural product extract powder.

Licorice (甘草, Glycyrrhiza, Liquorice Root ) has anti-inflammatory and immune function. It calms cramps, protects the liver and restores glycogen and nuclear sugar nucleic acids in liver cells. It lowers serum cholesterol, lowers blood pressure, and is effective for atherosclerosis. Licorice according to the present invention contains 0.5 to 1.5% by weight based on the total weight of the natural product extract powder.

Acanthopanax Senticosus is medicinal in stems and bark. The taste is spicy and bitter. The nature is warm. Liver and kidney supplements to strengthen muscles and skeletons. Prickly Ogapi according to the present invention contains 0.5 to 1.5% by weight based on the total weight of the natural product extract powder.

The nutritious mixed powder according to the present invention is green tea, whey calcium, algae calcium, shark cartilage powder, 11 vitamins, 5 mineral-containing raw materials, bilberry extract powder, spirulina, chlorella extract powder, pollen crushed powder, colostrum powder, casein It is selected from a powder consisting of phosphopeptides, soybean peptides, egg yolk lecithin and mixtures thereof, and contains 4 to 25% by weight based on the total weight of the growth promoting composition.

If the content is less than 4% by weight, the effect is hard to expect, and when used more than 25% by weight, the nutritional balance is reduced.

Cervi Cornu is a rusted antler that completely grows, tears, hardens, and fractures. It supplies essential calcium for bone development, acts on the spine, maintains posture, and grows hormones. Together, it promotes the branching of male and female hormones that affect growth. Green rust according to the present invention is used in the form of rust powder by pulverizing after removing the foreign matter, it contains 7 to 10% by weight based on the total weight of the nutrient mixture powder.

Calcium (whey calcium, seaweed calcium, shark cartilage powder) is the most necessary substance for life support. Calcium is the most abundant element in the human body after carbon, hydrogen, and oxygen. It is about 1 kg. Most of them are composed of bone and it in the same form as calcium phosphate, calcium carbonate, and about 1% of the body is in the body fluid in the ionic state or the protein and performs the physiological control function of the body. Calcium helps the formation of bones and teeth, as well as the absorption of vitamins A, C, D, P, as well as the three kinds of raw materials to help growth growth by preventing calcium deficiency.

The calcium component according to the present invention contains 60 to 75% by weight based on the total weight of the nutrient mixture powder.

Soybean peptide contains 90% or more of protein by hydrothermal extraction and enzymatic hydrolysis of skim soybeans to help disseminate protein efficiently to the human body, and becomes a component of body tissues such as muscles and connective tissues, and helps balance protein metabolism In addition to improving nutrition and malnutrition. Soybean peptide according to the present invention contains 4 to 5% by weight based on the total weight of the nutrient mixture powder.

Egg yolk lecithin helps maintain the brain and body's activity to prevent aging, supply high quality protein, excrete waste products, and nourish the brain for adolescents to help develop the brain. Egg yolk lecithin according to the present invention contains 4 to 5% by weight based on the total weight of the nutrient component powder.

Fructooligosaccharide maintains gut health by selectively propagating beneficial bacteria such as Bifidobacteria among intestinal bacteria. Fructooligosaccharide according to the present invention contains 3.5 to 4.5% by weight based on the total weight of the nutrient mixture powder.

The bilberry extract powder extracts and concentrates fresh bilberry (Vaccinum myrtillus) fruit, which contains a large amount of anthocyanidine, which improves vision protection, capillary protection and platelet coagulation. Bilberry extract powder according to the present invention contains 0.005 to 0.01% by weight based on the total weight of the nutrient ingredients powder.

Colostrum powder is rich in growth factors and vitamins, and contains large amounts of immunoglobulins, increasing resistance. The colostrum powder according to the present invention contains 0.5 to 0.9% by weight based on the total weight of the nutrient component powder.

Chlorella extract powder is an extract of chlorella unicellular algae in fresh water, rich in vitamins and various phytonutrients, and also contains Chlorella Growth Factor (CGF) containing essential amino acids and minerals. Chlorella extract powder according to the present invention contains 0.2 to 0.4% by weight based on the total weight of the nutrient ingredients powder.

Spirulina contains a large amount of protein, essential amino acids, fats, vitamins, and pigments. It not only harms free radicals, but also contains high levels of vitamin B ₁₂ and iron, increasing red blood cells in the blood. Spirulina according to the present invention contains 0.2 to 0.4% by weight based on the total weight of the nutrient mixture powder.

Pollen crushed powder is the crushed pollen shells collected by gathering the pollen bags on the hind legs of bees. It is rich in amino acids, vitamins, minerals, and proteins, so that it provides nutrition, stamina, normalization and resistance to metabolism. Enhance. Pollen crushed powder according to the present invention contains 1.2 to 1.6% by weight based on the total weight of the nutrient component powder.

Ham iron is a source of natural iron (Fe) that is highly absorbed from animal sources and helps to produce hemoglobin that sends oxygen to all blood vessels through the lungs as an absolute factor in making blood. Ham iron according to the present invention contains 0.01 to 0.02% by weight relative to the total weight of the nutrient ingredients powder.

Potassium (K) in potassium iodine prevents the body from acidifying and softens the body through nutrition, while iodine (I) helps produce thyroid hormone thyroxine and regulates energy production and weight balance do. Potassium iodine according to the present invention contains 0.001 to 0.003% by weight relative to the total weight of the nutrient mixture powder.

Magnesium hydroxide (Mg) is a mineral that aids mental stability. It balances acid alkali in human tissues, helps to produce lecithin, and is involved in nerve excitement and carbohydrate metabolism. Magnesium hydroxide of the present invention is 1.1 to 1.4% by weight based on the total weight of the nutrient mixture powder.

Manganese sulfate (Mg) is a component necessary for many kinds of enzymes and acts as an oxidation catalyst in the body, and when it is insufficient, the utilization rate of sugar decreases. Manganese sulfide according to the present invention contains 0.15 to 0.19% by weight based on the total weight of the nutrient component powder.

Zinc oxide (Zn) is required for the formation of ribohexane (RNA), deoxyribohexane (DNA) and protein synthesis, and is secreted by the pancreas to energize glucose. Zinc oxide according to the present invention contains 0.35 to 0.55% by weight based on the total weight of the nutrient ingredients powder.

Vitamin A (vitamin A, retinol retinol) plays an important role in vision and is a nutritional supplement for the eyes. Retinol is enzymatically converted into retinal in the liver, which binds to a protein called opsin in the retina of the eye. When light entering the eye stimulates the conjugate, it generates an electrical signal to the retinal cells, which can distinguish the shape and color of the object.

Vitamin A powder according to the present invention contains 0.12 to 0.18% by weight based on the total weight of the nutrient mixture powder.

Vitamin D ₃ (cholecalciferol) acts on calcium and phosphorus metabolism. Vitamin D ₃ is produced by the ultraviolet light of cholesterol in the skin. Vitamin D ₃ is oxidized and enzymatically converted into hydroxycholecalciferol in the liver and kidneys. Hydroxycalciferol plays a role in producing calcium binding proteins. The resulting calcium-binding protein is absorbed by incorporating calcium ions in the intestine and then transferred to bone tissue for bone formation.

Vitamin D ₃ according to the present invention contains 0.03 to 0.06% by weight based on the total weight of the nutrient mixture powder.

Vitamin E powder is mainly alpha tocopherol and acts as an antioxidant. Vitamin E suppresses tumors (cancer) and aging caused by oxides, and is effective in treating skin wounds. It also promotes vasodilation and blood circulation. Vitamin E powder according to the present invention contains 0.5 to 0.9% by weight based on the total weight of the nutrient mixture powder.

Vitamin B ₁ hydrochloride (thiamine, vitamin B ₁ ) is active in the form of thiamine pyrophosphate (TPP), which removes carbon dioxide from certain organics, attaches an aldehyde group, and transports it to the next reactant to metabolize proteins and carbohydrates. To promote. Vitamin B ₁ hydrochloride according to the present invention contains 0.03 to 0.06% by weight based on the total weight of the nutrient mixture powder.

Vitamin B ₂ (riboflavin, vitamin B ₂ ) is a precursor to flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which act as carriers of hydrogen atoms (electrons) in metabolism and promotes unsaturated fat metabolism and protein metabolism . Vitamin B ₂ according to the present invention contains 0.03 to 0.05% by weight based on the total weight of the nutrient mixture powder.

Nicotinamide (niacin) is a precursor of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which act as carriers of hydrogen atoms (electrons) in metabolism and is involved in bioenergy metabolism. Nicotinic acid amide according to the present invention contains 0.3 to 0.5% by weight based on the total weight of the nutrient mixture powder.

Pantothenic acid of calcium tenate forms a structural part of the coenzyme Coenzyme A and acts as an acyl group carrier. Calcium pantothenate according to the present invention contains 0.2 to 0.35% by weight based on the total weight of the nutrient ingredients powder.

Pyridoxin (pyridoxin) or pyridoxamine phosphate, a pyridoxin (vitamin B ₆ ) active form of vitamin B ₆ hydrochloride, acts as a coenzyme that transports amino groups in amino acid metabolism. Vitamin B6 hydrochloride according to the present invention contains 0.03 to 0.06% by weight based on the total weight of the nutrient mixture powder.

Vitamin B ₁₂ (cyanocobalamin) has a cobalt in the center of the corrin ring (cobalt) is involved in the synthesis of methionine and succinyl CoA and plays an important role in the formation and maturation of red blood cells. Lack of pernicious anemia can occur. Vitamin B ₁₂ according to the present invention contains 0.03 to 0.06% by weight based on the total weight of the nutrient mixture powder.

Vitamin C has a lactone ring structure and acts as a strong reducing agent (antioxidant) in metabolism. It is known to be effective for skin aging, carcinogen removal and cold prevention. It also acts as a cofactor to hydroxylation amino acids such as proline and lysine during collagen synthesis. Vitamin C according to the present invention contains 1.5 to 2.1% by weight based on the total weight of the nutrient mixture powder.

Folic acid (folic acid) is a carrier of single carbon bodies such as hydroxymethyl, formyl and methyl groups in the metabolism of amino acids, purines or pyrimidines. Folic acid according to the present invention contains 0.01 to 0.02% by weight based on the total weight of the nutrient mixture powder.

The additive according to the present invention is selected from the group consisting of crystalline cellulose, cocoa powder, aspartame, milk chocolate powder, sucrose fatty acid ester, hydroxypropyl methyl cellulose, and mixtures thereof, based on the total weight of the growth promoting composition. To 15% by weight.

Additives according to the present invention were added to improve the quality of the composition and to enhance the taste and aroma, in particular crystalline cellulose and sucrose fatty acid esters improve the fluidity of the composition during the filling and tableting of campels, aspartame, cocoa powder and milk chocolate powder flavor Silver improves the taste and flavor hue of the composition. In addition, hydroxypropyl methyl cellulose is added during coating (coating) to improve the dosage and stability of the tablet.

The growth promoting composition according to the present invention used a natural raw material having almost no side effects, and can be prepared in tablets, granules, and capsules with dry yeast as a main ingredient.

The composition according to the present invention is selected by taking an appropriate amount according to age, but preferably intake of about 3g to 6g per day, more preferably 3.6g to 5.4g intake per day has a growth promoting effect.

The compositions according to the invention are prepared by the following preparation method.

Step 1: Purchasing a natural raw material suitable for food standards, removing foreign substances and washing them, inserting natural raw materials and purified water into an extractor, extracting by heating, and filtering to prepare a primary X. Secondary extraction as described above and mixed with the first X and concentrated under reduced pressure to prepare a natural product extraction powder.

Step 2: Purchasing and mixing the ingredients of the nutrient mixture powder suitable for food standards in the blender to prepare a nutrient mixture powder.

Step 3: dry powder, yeast extract powder and the nutrient mixture powder is mixed to prepare a mixed powder.

Step 4: Add additives to the mixed powder to mix uniformly to prepare granules, and then to prepare granules, capsules and tablets.

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

Preparation of Examples 1 to 4 and Comparative Example 1

Preparation of Examples 1, 2, 3, and 4, in which yeasts were mixed in amounts of 10%, 30%, 50%, and 90% by weight in rat feed, respectively, and Comparative Example 1 without mixing yeast was prepared. The rate of change of body weight and feed intake and iliac length growth rate according to the amount of yeast were tested.

[Test Example 1]

Test of rate of change in body weight and feed intake

Sprague-Dawley male rats (3 weeks old) weighing 50 ± 10g were divided into 10 groups per body weight for 4 weeks, and then the changes in initial body weight and body weight after 4 weeks were measured. The correlation between dose and activity was measured and the results are shown in Table 1 below.

In order to extrapolate the human dose to the experimental animals, the intake per unit weight of the animal and the content per unit calorie were used. Examples 1 to 4 and Comparative Example 1 were freely ingested, and the dosage of the composition was adjusted to 0.0865% of the average diet.

Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Initial weight average (g) 60.3 ± 0.8 60.2 ± 0.9 59.9 ± 1.3 60.1 ± 1.2 59.9 ± 1.4 Weight average after 1 week 102.4 ± 1.1 103.7 ± 1.2 104.1 ± 1.3 108.3 ± 1.7 107.9 ± 1.4 Weight average after 2 weeks 146.6 ± 1.6 150.9 ± 1.8 153.2 ± 1.4 157.5 ± 2.0 157.3 ± 1.8 Average weight after 3 weeks 192.7 ± 2.8 198.2 ± 2.3 200.5 ± 2.2 208.4 ± 2.2 207.2 ± 2.3 Weight average after 4 weeks 242.5 ± 4.3 250.2 ± 3.9 251.3 ± 3.7 261.2 ± 3.4 260.4 ± 2.8 Initial feed intake average (g) 13.8 ± 1.7 14.2 ± 2.0 13.6 ± 2.1 13.6 ± 1.2 12.8 ± 2.0 Feed intake average after 1 week 15.9 ± 2.2 17.0 ± 2.1 16.8 ± 2.4 16.8 ± 2.4 16.1 ± 1.9 Feed intake average after 2 weeks 19.9 ± 2.1 19.7 ± 1.5 18.1 ± 2.0 19.2 ± 2.6 18.6 ± 1.8 Feed intake average after 3 weeks 20.8 ± 2.6 21.0 ± 1.3 21.7 ± 3.1 19.4 ± 2.7 20.5 ± 2.3 Feed intake average after 4 weeks 22.1 ± 3.0 20.1 ± 2.2 21.9 ± 3.4 21.2 ± 3.1 21.2 ± 4.2

As can be seen in Table 1, the average body weight and the change after 4 weeks in Comparative Example 1 were 182.2 g on average, but the change in Examples was 190.0 g in Example 1, 191.4 g in Example 2, 201.1 g in Example 3, Example 4 shows a change of 200.5g, respectively, and it was confirmed that the yeast showed a significant weight change since the content of 50%.

Feed intake did not show a particular difference in each group, it was confirmed that the administration of the above example composition did not affect the feed intake, and that the weight change was not due to the difference in feed intake.

[Test Example 2]

Iliac length growth measurement

In order to observe the change in bone length growth according to the administration of Comparative Example 1 and Examples 1 to 4 was administered for 5 days in the same manner as in Test Example 1, the iliac length growth was observed after two days and the results are shown in Figure 1 .

As can be seen in Figure 1 Comparative Example showed a bone length growth of 720.1 ± 15.4 ㎛, while Examples 1 and 2 showed a bone length of 726.2 ± 18.7 ㎛ and 724.8 ± 22.6 ㎛, respectively, statistically significant with Comparative Example 1 No difference was observed, but Examples 3 and 4 showed excellent bone length growth promoting effects of 776.7 ± 31.4 μm and 779.3 ± 24.6 μm, respectively (p <0.01).

[Test Example 3]

Measurement of Growth Hormone Change Rate in Blood

In order to measure the rate of change of the growth hormone in blood according to the administration of Comparative Examples 1 and 4, Comparative Example 1 and Examples 1 to 4 were assigned to each of the group administered to Comparative Example 1 After the administration of the Examples, blood growth hormone was measured using an ELISA method, and the results are shown in FIG. 2.

Each group administered Examples 1 to 4 did not show a significant difference from the results of Comparative Example 1, which means that the administration of Examples 1 to 4 did not increase the secretion of growth hormone in the blood, and growth produced hormone secretion. It does not mean that it is due to.

Preparation of Examples 5-10

Based on the results of Test Examples 1 to 3, the inventors of the present invention contained more than 50% by weight of dry yeast based on the total weight of the composition, and tested the growth promoting effect according to the natural extract powder or nutrient mixture powder. Taking the embodiments according to the invention in the growing adolescents to determine the growth effect according to the content of dry yeast, natural product extract powder and nutrient mixture powder.

Example 5

Preparation of growth promoting granules containing dry yeast and additives.

In the blending ratio shown in Table 2 below, sucrose fatty acid ester was added to the dried granules uniformly mixed according to the preparation method to uniformly mix the granules.

ingredient Compounding ratio (% by weight) Dry yeast 88.3 Crystalline cellulose 2.4 Cocoa Powder 5.8 Aspartame 0.2 Milk Chocolate Powder 2.5 Sucrose Fatty Acid Ester 0.8 Sum 100

Example 6

Preparation of Growth Promotion Granules Containing Dry Yeast, Nutritious Mixture Powder and Additives

In the mixing ratio shown in Table 3 below, sucrose fatty acid ester was added to the dried granules uniformly mixed according to the preparation method to uniformly mix the granules.

ingredient Compounding ratio (% by weight) Dry yeast 63.3 Nutritional Supplements ² 25 Crystalline cellulose 2.4 Cocoa Powder 5.8 Aspartame 0.2 Milk Chocolate Powder 2.5 Sucrose Fatty Acid Ester 0.8 Sum 100

The nutrient mixture powder ²⁾ is 28.807% by weight whey calcium salt, 32.992% by weight seaweed calcium, 6.102% by weight shark cartilage powder, 8.23% by weight green tea powder 8.23% by weight, soybean peptide 4.527% by weight, yolk lecithin 4.527% by weight, 4.115% by weight fructooligosaccharide, 0.15% by weight of vitamin A powder, 0.706% by weight of vitamin E powder (50%), 1.969% by weight of vitamin C powder, 0.043% by weight of vitamin B ₂ , 0.048% by weight of vitamin B ₆ hydrochloride , 0.407% nicotinamide, 0.014% folic acid, 0.471% zinc oxide, 0.043% vitamin B ₁ hydrochloride, 0.267% calcium pantothenate, 0.048% vitamin B ₁₂ (0.1%), 0.048% vitamin D ₃ , Manganese sulfide 0.171% by weight, magnesium hydroxide 1.209% by weight, potassium iodine 0.002% by weight, bilberry extract powder 0.009% by weight, spirulina 0.278% by weight, chlorella extract powder 0.278% by weight, pollen crushed powder 1.421% by weight, colostrum powder 0.792% by weight , Caseinphosphopeptide 2.311% by weight and 0.015% by weight of ham iron was added and mixed, followed by the composition shown in Table 3 above.

Example 7

Preparation of growth promoting granules containing dry yeast, natural extract powder and additives

In the blending ratios shown in Table 4 below, sucrose fatty acid ester was added to the dried granules uniformly mixed according to the preparation method to uniformly mix the granules.

ingredient Compounding ratio (% by weight) Dry yeast 63.3 Natural Extraction Powder ¹ 25 Crystalline cellulose 2.4 Cocoa Powder 5.8 Aspartame 0.2 Milk Chocolate Powder 2.5 Sucrose Fatty Acid Ester 0.8 Sum 100

The raw material extract powder ¹⁾ is 31.5% by weight safflower seed, malt 18.9% by weight, 12.86% by weight, 12.86% by weight, earth and sand 12.6% by weight, bokbunja 12.6% by weight, 2.62% by weight, mountain lion 2.62% by weight , 1.05% by weight, 1.05% by weight of zojoin, 1.05% by weight of thorns, 1.05% by weight, 1.05% by weight of licorice, 1.05% by weight of Licorice and mixed, and then added according to the composition of Table 4.

Example 8

Preparation of growth promoting granules containing dry yeast, natural product extraction powder, nutrient mixture powder and additives.

In the blending ratios shown in Table 5 below, sucrose fatty acid ester was added to the dried granules uniformly mixed according to the preparation method to uniformly mix the granules.

ingredient Compounding ratio (% by weight) Dry yeast 60.1 Natural product extract powder ¹⁾ 3.9 Nutritional Powder Mix ²⁾ 24.3 Crystalline cellulose 2.4 Cocoa Powder 5.8 Aspartame 0.2 Milk Chocolate Powder 2.5 Sucrose Fatty Acid Ester 0.8 Sum 100

The natural product extract powder ¹⁾ and the nutrient ingredient powder ²⁾ are the same as the composition of Tables 3 and 4.

Example 9

Preparation of growth-promoting capsules containing dry yeast, natural product extraction powder, nutrient mixture powder and additives.

In the blending ratio shown in Table 5, the granules of Example 8 were charged with an automatic capsule charger to prepare a capsule.

Example 10

Preparation of growth-promoting tablets containing dry yeast, natural product extraction powder, nutrient mixture powder and additives.

Tableting the granules of Example 8 with a tableting machine at the blending ratio shown in Table 6, spraying HPMC [liquor: water = 9: 1 (15 times)] solution to the tablets tableted while the protective coating (coating) Tablets were prepared by coating with drying to volatilize.

ingredient Compounding ratio (% by weight) Dry yeast 60.1 Natural product extract powder ¹⁾ 3.9 Nutritional Powder Mix ²⁾ 24.3 Crystalline cellulose 2.4 Cocoa Powder 5.0 Aspartame 0.2 Milk Chocolate Powder 2.5 Sucrose Fatty Acid Ester 0.8 Hydroxypropylmethylcellulose 0.8 Sum 100

The natural product extract powder ¹⁾ and the nutrient ingredient powder ²⁾ are the same as described in Tables 3 and 4.

[Test Example 4]

Test to measure the rate of change of body weight and feed intake by administration of natural extract powder and nutrient mixture powder.

Sprague-Dawley male rats (3 weeks old) of 60 ± 10 g were divided into 20 rats in each group by weight and administered with Examples 5 to 8 according to the present invention and Comparative Example 2, which is a general feed without addition, for 4 weeks. The change in body weight and body weight after 4 weeks was measured, and then the correlation between the administration of the natural extract powder and the nutrient mixture powder and the weight gain was measured using the average value. The results are shown in Table 7 below.

In order to extrapolate the human dose to the experimental animals, the intake per unit weight of the animal and the content per unit calorie were used. Comparative examples and examples were mixed freely in the feed and the dose was adjusted to 0.0865% of the average diet.

Comparative Example 2 Example 5 Example 6 Example 7 Example 8 Initial weight average (g) 59.9 ± 0.9 60.9 ± 1.2 60.5 ± 0.7 60.1 ± 0.9 60.6 ± 0.7 Weight average after 1 week 101.3 ± 1.2 107.7 ± 1.8 110.6 ± 1.4 112.4 ± 0.9 120.4 ± 1.3 Weight average after 2 weeks 145.3 ± 1.7 158.6 ± 1.9 164.9 ± 1.5 166.7 ± 1.7 177.6 ± 2.2 Average weight after 3 weeks 191.6 ± 2.7 208.7 ± 2.1 216.3 ± 3.7 215.6 ± 4.3 236.7 ± 3.6 Weight average after 4 weeks 240.3 ± 3.8 260.5 ± 3.8 271.2 ± 4.2 270.4 ± 3.2 296.5 ± 5.0 Initial feed intake average (g) 14.0 ± 2.1 14.3 ± 2.4 13.7 ± 1.7 13.8 ± 2.6 14.7 ± 3.4 Feed intake average after 1 week 16.3 ± 3.2 16.5 ± 2.5 17.3 ± 2.3 17.4 ± 3.7 17.2 ± 2.3 Feed intake average after 2 weeks 19.1 ± 1.3 19.8 ± 2.3 18.9 ± 1.5 18.6 ± 2.3 18.7 ± 1.7 Feed intake average after 3 weeks 20.5 ± 2.7 20.7 ± 1.4 19.7 ± 2.9 21.4 ± 2.6 20.9 ± 3.3 Feed intake average after 4 weeks 21.5 ± 3.5 20.3 ± 2.3 20.9 ± 4.1 20.2 ± 2.5 21.6 ± 3.2

As can be seen from Table 7, Comparative Example 2 initial body weight and the change after 4 weeks was an average of 180.4g, but in Example 5, Example 5 is 199.6, Example 6 is 210.7, Example 7 is 210.3, Example 8 is A change of 235.9 g was shown, and a synergistic effect was obtained when combined administration (Example 8) compared with the administration of natural extract powder (Example 7) or nutrient mixture powder (Example 6) alone with yeast. Could check.

Feed intake did not show a particular difference in each group, it was confirmed that the weight change was not due to the difference in feed intake.

[Test Example 5]

Only 20 subjects in the 10 to 11 year old male children whose height is in the range of 145 ± 5cm were assigned to each group so as to distribute the kidneys evenly, and then administered 5.4 g of Examples 5 to 8 per day. After 6 months of administration, the change in height was measured in comparison with Comparative Example 3, in which the same amount of mock tablet was taken, and the results are shown in Table 8 below.

division Comparative Example 3 Example 5 Example 6 Example 7 Example 8 Average height (cm) 0 months 146.7 6 months 150.2 0 months 146.3 6 months 152.9 0 months 145.7 6 months 152.9 0 months 145.6 6 months 152.5 0 months 145.6 6 months 155.1 Average height change 3.5 cm 6.0 cm 7.2 cm 6.9 cm 9.5 cm Average growth rate (%) 2.39% 4.10% 4.94% 4.74% 6.52%

As shown in Table 8, when using a combination of natural product extract powder and nutrient mixture powder (Example 8) compared to Comparative Examples 3 and 5 to 7, the results of the animal test that the growth promoting effect is improved even in the clinical I could confirm it.

The growth promoting composition of the present invention, which is composed of dry yeast, natural extract powder, and nutrient mixture powder, shows an excellent growth promoting effect on the change in height of adolescents in growing season, and has the advantage of being easily consumed without side effects.

While the present invention has been described in detail with reference to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the scope and spirit of the present invention, and such modifications and variations are included in the appended claims. It is natural to belong.

Claims (9)

delete Dry yeast selected from the group consisting of lactic acid yeast, vitamin yeast, brewer's yeast, baker's yeast, yeast extract and mixtures thereof, from 50 to 90% by weight relative to 100% by weight of the total composition; Safflower seed 25 to 35% by weight, malt 15 to 25% by weight, 10 to 15% by weight, earth and sand 10 to 15% by weight, bokbunja 10 to 15% by weight, Baekbongryeong 2 to 5% by weight, based on 100% by weight of natural product extract powder, 2 to 5% by weight of hawthorn, 0.5 to 1.5% by weight of zojoin, 0.5 to 1.5% by weight of cultivars, 0.5 to 1.5% by weight, Angelica 0.5 to 1.5% by weight, 0.5 to 1.5% by weight of licorice and 0.5 to 1.5% by weight of licorice. Natural product extract powder 1 to 25% by weight; Green sugar 7-10% by weight, calcium 60-75% by weight, soybean peptide 4-5%, egg yolk lecithin 4-5% by weight, bilberry extract powder 0.005-0.01% by weight, colostrum powder 0.5 to 0.9% by weight, chlorella extract powder 0.2 to 0.4% by weight, spirulina 0.2 to 0.4% by weight, pollen crushed powder 1.2 to 1.6% by weight, casein phosphopeptide 2 to 3% by weight, vitamins 11 to 2 to 4% by weight And 4 to 25% by weight of the nutrient mixture powder consisting of 1 to 2% by weight of 5 kinds of mineral-containing raw materials; And 5 to 15% by weight of an additive selected from the group consisting of crystalline cellulose, cocoa powder, aspartame, milk chocolate powder, sucrose fatty acid ester, hydroxypropyl methyl cellulose and mixtures thereof; Growth promoting composition, characterized in that consisting of delete delete delete delete delete delete delete

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