CN108451984A

CN108451984A - A kind of preparation method of Endothelium Corneum Gigeriae Galli extract

Info

Publication number: CN108451984A
Application number: CN201810550423.9A
Authority: CN
Inventors: 李先强
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-05-31
Filing date: 2018-05-31
Publication date: 2018-08-28

Abstract

A kind of preparation method of Endothelium Corneum Gigeriae Galli extract is mainly pressed following step and is carried out：One, the membrane of a chicken's gizzard is cleaned up, high-temperature baking, 120 DEG C of temperature, becomes golden yellow；Two, the roasted the membrane of a chicken's gizzard is broken into powder, 3 times of quality is added, clear water is added to stir evenly, increased temperature to 100 DEG C, become mixing decoction liquor；Three, mixing decoction liquor is subjected to strainer filtering, filtered fluid is subjected to centrifugal clarification, takes clarified solution；Four, clarified solution is poured into another glass container, temperature is reduced to 25 DEG C ~ 30 DEG C, and ether is added, and addition is 1/3 volume of clarified solution, and closing stirring extraction 7 ~ 8 minutes is stood, after layering, separation takes upper layer ether to extract mixed liquor；Five, it puts the container for extracting mixed liquor equipped with ether into destilling tower, increases temperature and evaporate ether, it is Endothelium Corneum Gigeriae Galli extract that container bottom, which will be left behind powder dress object,.

Description

A kind of preparation method of Endothelium Corneum Gigeriae Galli extract

Technical field

The present invention relates to a kind of preparation methods of the extract of the membrane of a chicken's gizzard, more particularly to be with the extraction side of extraction Method belongs to pharmaceutical technology field.

Background technology

For the drying gizzard of Chordata Phasianidae animal family chicken (Gallus gallus domesticus Brisson) Inner wall（Muscular stomach）.It produces all parts of the country.After killing chicken, chicken gizzard is taken out, removes inner wall immediately, cleans, dries, life is used or fried and uses.

Appropriate digested bad, sallow complexion, do not think Na Gu, infantile malnutrition, body become thin, the big abdominal distension of abdomen, it is weakness of the spleen and the stomach, food The condition subjects such as product turgor, intestinal tuberculosis, bone tuberculosis are edible.

Family chicken, poultry.Mouth is short and hard, is in slightly coniform, upper mouth is slightly bent.Shape is split in nostril, is there is squamous valve.Eye has wink Film.There are comb, throat both sides to have wattle on head, is usually in maroon；Comb is tall and big with male person, and female person is low small；Wattle also with Male person is big.The wing is short；Plumage color is female, male difference, and male person's plumage color is more beautiful, there is the long and tail feathers of floridity；Female person's tail feathers is very short.Foot is strong Strong, instep, plantar and toe are had dissepiment；Toe 4, preceding 3 toe, rear 1 toe, hallux is short and small, and position is slightly higher, male person's tarsometatarsus portion rear have away from.

Influence to human stomach function：Healthy People takes orally bronze end 5g in Grilled chicken, through 45-60 minutes, gastric secretion ratio Control value increases 30-37%, restores normal in 2 hours.Gastric acidity also obviously increases.Free acid or total acidity are in 1 chicken of taking medicine It is generally begun to ramp up after when Nei Jin-is medicinal, reached peak in 1-2 hours, be gradually reduced later, restore normal after 3 hours.Wherein The peak of free acid is 0.19-0.24%, increases 32-113% than control value；The peak of total acidity is 0.2-0.32%, than just Constant value increases 25-75%.Though the enhancing of eupepsy is slower, hold time relatively long.Stomach motion function is remarkably reinforced, and shows Stomach movement extends and peristaltic wave enhancing, therefore gastric emptying rate is accelerated.The membrane of a chicken's gizzard itself is containing only micro pepsin and starch Enzyme after medication the secretory volume of gastric juice can increase and stomach movement enhancing, it is believed that may be to pass through body fluid after the membrane of a chicken's gizzard is digested and assimilated Caused by the neuromuscular of factor excitement stomach wall.Also have and be considered that gastric hormone promotes stomachial secretion function.

Influence of the membrane of a chicken's gizzard difference processed product to mouse stomach propulsion functions：The membrane of a chicken's gizzard health product and different processed products：It fries Product, sand scald product, vinegar product, baking product gavage 0.2m1/10g to mouse stomach propulsion functions situation and compared with physiological saline.Though The propulsion functions of various processed products have the tendency that enhancing, but not significantly（P<0.05).As a result the food digesting action of the membrane of a chicken's gizzard is prompted It is not caused by local action or direct stimulating intestine and stomach of the drug in stomach move, it may be possible to enter blood after drug digestion and pierce Swash gastric gland secretion to increase and play indirect digestion-aid effect.

Antitumaous effect：In vitro test；The membrane of a chicken's gizzard plays the role of inhibiting tumour cell.After oral this product, gastric secretion, acid Degree and digestion power improve, and stomach movement is reinforced, and Emptying Rate is accelerated, and the effect of secreting is urged to be even stronger than digested tankage, effect by way of be seemingly through Enter in blood after digesting and assimilating, the nerve muscle apparatus of excited stomach wall by humoral factor.

Invention content

The membrane of a chicken's gizzard contains gastric hormone, keratin, micro pepsin, amylase, multivitamin.Be born 4-8 weeks it is small The chicken gizzard inner membrance also yellow derivative containing bilitrien and biliverdin, and contain lysine, histidine, arginine, glutamic acid Aspartic acid, leucine, threonine, serine, glycine, alanine, isoleucine, tyrosine（tyrosine）, phenylpropyl alcohol ammonia Acid, proline, the trace elements such as 18 kinds of amino acid such as tryptophan and aluminium, calcium, chromium, cobalt, copper, iron, magnesium, manganese, molybdenum, lead, zinc.Containing stomach Hormone, keratin etc..Therefore, medical substance is extracted from the membrane of a chicken's gizzard important pharmacy meaning.

A kind of preparation method of Endothelium Corneum Gigeriae Galli extract solves the problems, such as to adopt the technical scheme that by following step progress： One, the membrane of a chicken's gizzard is cleaned up, puts baking tower into and carries out high-temperature baking, temperature is increased to 120 DEG C, keeps temperature baking 10 ~ 20 Minute becomes golden yellow；Two, the roasted the membrane of a chicken's gizzard is broken into powder, powder is put into glass container, 3 times of quality are added and add clear water It stirs evenly, increases temperature to 100 DEG C, stirred when decocting, decocting dissolving becomes mixing decoction liquor for 5 ~ 6 minutes；It three, will mixing Decoction liquor carries out strainer filtering, and filtered fluid is carried out centrifugal clarification, takes clarified solution；Four, clarified solution is poured into another glass to hold Device, temperature are reduced to 25 DEG C ~ 30 DEG C, and ether is added, and addition is 1/3 volume of clarified solution, and closing stirring extracts 7 ~ 8 minutes, It stands, after layering, separation takes upper layer ether to extract mixed liquor；Five, the container that mixed liquor is extracted equipped with ether is put into destilling tower, It increases temperature to evaporate ether, it is Endothelium Corneum Gigeriae Galli extract that container bottom, which will be left behind powder dress object,.

A kind of advantageous effect of the preparation method of Endothelium Corneum Gigeriae Galli extract is：A kind of preparation method of Endothelium Corneum Gigeriae Galli extract first will The male the membrane of a chicken's gizzard cleans up, and avoids impurity mixing extraction flow；Then high-temperature baking is carried out, the protein sealing of the membrane of a chicken's gizzard is changed Physical property, so that the trace element in the membrane of a chicken's gizzard is detached with organic matter, can it is more soluble in water as aqueous solution, then in water Ether is added in solution to be extracted, microelement substance is turned to be dissolved in ether, by detaching, distilling, finally by ether Volatilization, achieves the medical substance in the membrane of a chicken's gizzard.

Specific implementation mode

Embodiment：A kind of preparation method of Endothelium Corneum Gigeriae Galli extract is mainly pressed following step and is carried out：One, by the membrane of a chicken's gizzard It cleans up, puts baking tower into and carry out high-temperature baking, temperature is increased to 120 DEG C, keeps temperature to toast 10 ~ 20 minutes and turns golden yellow Color；Two, the roasted the membrane of a chicken's gizzard is broken into powder, powder is put into glass container, 3 times of quality are added, clear water is added to stir evenly, Temperature is increased to 100 DEG C, is stirred when decocting, decocting dissolving becomes mixing decoction liquor for 5 ~ 6 minutes；Three, will mixing decoction liquor into Filtered fluid is carried out centrifugal clarification, takes clarified solution by row strainer filtering；Four, clarified solution is poured into another glass container, temperature drop Down to 25 DEG C ~ 30 DEG C, ether is added, addition is 1/3 volume of clarified solution, and closing stirring extraction 7 ~ 8 minutes is stood, layering Afterwards, separation takes upper layer ether to extract mixed liquor；Five, it puts the container for extracting mixed liquor equipped with ether into destilling tower, increases temperature Ether is evaporated, it is Endothelium Corneum Gigeriae Galli extract that container bottom, which will be left behind powder dress object,.

Claims

1. a kind of preparation method of Endothelium Corneum Gigeriae Galli extract, feature is mainly to be carried out by following step：A kind of the membrane of a chicken's gizzard extraction The preparation method of object solves the problems, such as to adopt the technical scheme that by following step progress：One, the membrane of a chicken's gizzard is cleaned up, is put into It toasts tower and carries out high-temperature baking, temperature is increased to 120 DEG C, keeps temperature to toast and becomes within 10 ~ 20 minutes golden yellow；It two, will be roasted The membrane of a chicken's gizzard is broken into powder, and powder is put into glass container, 3 times of quality is added, clear water is added to stir evenly, and increases temperature to 100 DEG C, it is stirred when decocting, decocting dissolving becomes mixing decoction liquor for 5 ~ 6 minutes；Three, mixing decoction liquor is subjected to strainer filtering, it will Filtered fluid carries out centrifugal clarification, takes clarified solution；Four, clarified solution is poured into another glass container, temperature is reduced to 25 DEG C ~ 30 DEG C, ether is added, addition is 1/3 volume of clarified solution, and closing stirring extraction 7 ~ 8 minutes is stood, after layering, separation takes Layer ether extracts mixed liquor；Five, it puts the container for extracting mixed liquor equipped with ether into destilling tower, increases temperature and evaporate ether, It is Endothelium Corneum Gigeriae Galli extract that container bottom, which will be left behind powder dress object,.