CN106174193B - A kind of health-care food composition of auxiliary reducing blood lipid containing green plum and preparation method thereof - Google Patents

A kind of health-care food composition of auxiliary reducing blood lipid containing green plum and preparation method thereof Download PDF

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CN106174193B
CN106174193B CN201610560924.6A CN201610560924A CN106174193B CN 106174193 B CN106174193 B CN 106174193B CN 201610560924 A CN201610560924 A CN 201610560924A CN 106174193 B CN106174193 B CN 106174193B
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green plum
parts
health
reducing blood
blood lipid
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CN106174193A (en
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钱书元
邹伟权
缪来耿
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Guangdong four seasons beautiful Industrial Co., Ltd.
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Shenzhen Sijiyoumei Trade Co Ltd
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Abstract

The invention discloses a kind of health-care food composition of auxiliary reducing blood lipid containing green plum and preparation method thereof, the health-care food composition of auxiliary reducing blood lipid of the present invention containing green plum includes the preparing raw material of following weight portion meter：1~4 part of 26~30 parts of green plum, 8~12 parts of rhizoma imperatae, 12~16 parts of rhizoma atractylodis, 2~6 parts of the fruit of Chinese wolfberry, 4~8 parts of Momordica grosvenori and Amomum cardamomum.The present composition has reducing blood lipid, the effect of protection liver kidney, can be used as the health-care assistance food of hyperlipemia.

Description

A kind of health-care food composition of auxiliary reducing blood lipid containing green plum and preparation method thereof
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of health food group of the auxiliary reducing blood lipid containing green plum Compound and preparation method thereof.
Background technology
Blood fat refers to the content of the fat element such as free fatty in human plasma, phosphatide, sterol and triglyceride.Blood In slurry the content health value of blood fat it is general in 130mg/dl (every deciliter of milligram) below；All being medically referred to as more than 160mg/dl For blood fat element is exceeded, as high fat of blood.The concentration of the lipid compositions such as hyperlipemia plasma cholesterol, triglycerides, total fat More than arm's length standard.
Infringement of the high fat of blood to body be concealment, gradually, progressive and general, its direct infringement is to accelerate whole body Atherosclerosis, and then cause numerous relevant diseases, because the vitals of whole body will rely on artery blood supply, oxygen supply, Once artery is blocked by atheromatous plaque, serious consequence is may result in.Numerous studies data shows that hyperlipemia is cerebral apoplexy, hat Worry, myocardial infarction, cardiac sudden death be independent and important hazards.Additionally, hyperlipemia is also to promote hypertension, sugar tolerance An abnormal, important risk factor of diabetes.Hyperlipemia can also result in fatty liver, cirrhosis, cholelithiasis, pancreatitis, eye Bottom bleeding, blindness, peripheral vascular disease, limping, hyperuricemia.Some primary and familial hyperlipemia can also go out Existing tendon shape, nodositas, palm plane and xanthoma, embryotoxon etc. around eye socket.
At present, the medicine for being usually used in treating high fat of blood has Statins fat regulation medicine, fibrates fat regulation medicine, nicotinic acid class and its derivative Although thing, cholic acid chelating agent and probucol etc., these medicines have obvious effect for reducing blood fat, but long-term taking to liver kidney Toxic and side effect it is big, and easily recur after being discontinued.Therefore, hyperlipemic patients are being focused on outside reasonable diet and appropriate exercise, also The health food for aiding in reducing blood lipid is needed to reach gentle conditioning body, slows down the toxic and side effect to liver kidney, and be difficult recurrence Purpose.
Green plum (Prunus mumc, Sourplum), also known as smoked plum, fruit plum, is that rose family apricot belongs to arbor, main product in the Changjiang river with The vast Hills in south, are the traditional medicine-food two-purpose fruits of China, with unique whole intestines that promote the production of body fluid, protect liver, clarification blood and The health-care efficacies such as dispelling fatigue.Chinese patent application CN101263896A discloses a kind of health beverages, its by mulberry leaf, purple perilla, Mushroom, matrimony vine, luxuriant pomegranate and green plum are prepared from, with the functions such as hypoglycemic, reducing blood lipid, enhancing liver function, but effect Effect is not obvious.
Therefore, in order to give full play to application effect of the green plum in terms of reducing blood lipid, while providing a kind of to hyperlipemic patients Effectively aid in reducing blood lipid and the health food of liver kidney can be protected, it is necessary to research and develop a kind of health care food of the auxiliary reducing blood lipid containing green plum Product composition.
The content of the invention
In order to overcome the deficiencies in the prior art, it is an object of the invention to provide a kind of guarantor of the auxiliary reducing blood lipid containing green plum Health food composition, said composition effectively aids in reducing blood lipid, and has protective effect to hepatic and renal function.
To achieve these goals, technical scheme is as follows：
It is a kind of containing green plum auxiliary reducing blood lipid health-care food composition, including following weight portion meter preparing raw material：It is blue or green 26~30 parts of plum, 8~12 parts of rhizoma imperatae, 12~16 parts of rhizoma atractylodis, 2~6 parts of the fruit of Chinese wolfberry, 4~8 parts of Momordica grosvenori and Amomum cardamomum 1~4 Part.
As the preferred embodiment of the present invention, it is described containing green plum auxiliary reducing blood lipid health-care food composition include with The preparing raw material of lower weight portion meter：28 parts of green plum, 10 parts of rhizoma imperatae, 14 parts of rhizoma atractylodis, 4 parts of the fruit of Chinese wolfberry, 6 parts of Momordica grosvenori and Amomum cardamomum 3 parts.
In order that the health-care food composition for obtaining the auxiliary reducing blood lipid containing green plum preferably plays a role, the combination Thing is preferably oral liquid, and present invention also offers corresponding preparation method, it is specific as follows：
S1, take green plum, be enucleated and rub, be subsequently adding 5~6 times of water of amount of green plum weight, temperature be 50~60 DEG C, it is micro- Wave power is to process 1.5~2h, filtering under 600~800w, and filter residue adds 3~4 times of water of amount of green plum weight, temperature be 50~ 60 DEG C, microwave power be 600~800w under process 20~40min, filtering, merging filtrate, filtrate is in vacuum-concentrcted to 60 Relative density is 1.10~1.20 medicinal extract one at DEG C, is cooled standby；
S2, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 6~8 times of water of amount of inventory, immersion 30 ~60min, then heating is boiled, and 1.5~2h, filtering are extracted in insulation, and filter residue adds 4~6 times of water of amount of inventory, protected after boiling Temperature extracts 40~60min, filters, merging filtrate, and filtrate is 1.10~1.20 in vacuum-concentrcted to relative density at 60 DEG C Medicinal extract two, cool standby；
S3, the medicinal extract one and medicinal extract two are mixed, it is 65~70% ethanol to add 2~3 times of volume fractions of cream weight, is filled Divide stirring, 24~48h is stood at room temperature, take supernatant, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtain liquid；
S4, the water toward 6~8 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the clarification of 0.5~1g/L Agent, 20~30min of stir process under 400~500w microwave powers, stand 6~8h, filtering, toward filtrate addition 0.1~ 0.3g/L preservatives, filtering is obtained final product after standing.
Further, the fining agent is shitosan.
Further, the preservative is the weight of the mixture of phytic acid and lentinan, the phytic acid and lentinan Than being 1:(0.4~0.7).
In the inventive solutions, the rhizoma imperatae of the composition is the dry rhizome of grass cogongrass；It is grey Art is the dry rhizome of feverfew Atractylis lancea；The fruit of Chinese wolfberry is the dry mature fruit of plant of Solanaceae lycium barbarum；Momordica grosvenori is The dry fruit of cucurbitaceous plant Momordica grosvenori；Amomum cardamomum is the dry mature fruit (used time removes shell) of zingiberaceous plant Amomum cardamomum.
Inventor have studied the lipid-lowering effect of green plum first, it is found that its water extract has reduction to act on blood fat, to liver It is dirty to have protective effect, but action effect is not obvious.In order to improve the action effect of green plum, inventor has carried out substantial amounts of research And experiment, it is determined that the combination of rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum and green plum and proportioning, the combination reducing blood lipid Effect substantially, and with protection liver kidney effect；Also, said composition can coordinate with Statins fat regulation medicine to be taken, and can be had Effect slows down toxic and side effect of the Statins fat regulation medicine to liver kidney；Meanwhile, said composition using sugariness and the green plum of Momordica grosvenori acidity, Astringent sense is coordinated, and strengthens the agreeable to the taste sense of the present composition.
In health food, oral liquid has that consumption is small, bioavilability is high, the advantage such as convenient to take, so the present invention contains The health-care food composition of the auxiliary reducing blood lipid of green plum is preferably oral liquid.In order to ensure the drug effect of the present composition and oral The stabilization of liquid, individually water extraction is carried out in preparation method of the present invention to green plum, and with microwave radiation technology, fully in extraction green plum Active component, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum then mix is boiled with decocting, is carried out after the medicinal extract mixing for obtaining Alcohol precipitation then after dealcoholysis, diluting, is made with removing the non-medicinal ingredient such as most of gelatinized starch, tannin, albumen, resin, grease Combined to remove resin, the mucilaginous substance isocolloid material of indissoluble with microwave with fining agent so that liquid clear, system is steady It is fixed, preservative is eventually adding, filtering obtains final product oral liquid after standing.The health food combination of auxiliary reducing blood lipid of the present invention containing green plum Adult's consumption of thing oral liquid is 20~30ml/d.The present invention uses shitosan as fining agent in the clarifying treatment of liquid, Accelerate in combination with microwave treatment indissoluble resin, the precipitation of mucilaginous substance isocolloid material with sedimentation, it is ensured that liquid system it is steady It is fixed, it is to avoid muddy or precipitation occurs during storage in liquid.Preservative of the present invention is using the mixed of phytic acid and lentinan Compound, Synergistic antimicrobial anti-corrosion, and prevent liquid brown stain, it is ensured that the organoleptic quality of oral liquid；The weight of phytic acid and lentinan Than being preferably 1:Antimicrobial preservative is better when (0.4~0.7).
Therefore, compared with prior art, advantage of the invention is that：
(1) health-care food composition of auxiliary reducing blood lipid of the present invention containing green plum has reducing blood lipid, the effect of protection liver kidney, Can individually be taken as the health-care assistance food of hyperlipemia, can also be used cooperatively with the fat regulation medicine such as Statins, not only Auxiliary reducing blood lipid, and protection liver kidney, slow down toxic and side effect of the long-term taking Western medicine to liver kidney；And present composition formula Simply, low cost, fits in good taste.
(2) the preparation method process stabilizing of the health-care food composition of auxiliary reducing blood lipid of the present invention containing green plum, condition can Control, can industrialized production, and obtained product stabilization, be conducive to promote.
Specific embodiment
Below by way of the description of specific embodiment, the invention will be further described, but this is not to limit of the invention System, those skilled in the art's basic thought of the invention, various modifications may be made or improves, but without departing from this The basic thought of invention, within the scope of the present invention.
The health-care food composition of the auxiliary reducing blood lipid of embodiment 1, the present invention containing green plum and its preparation
Formula：Green plum 26kg, rhizoma imperatae 8kg, rhizoma atractylodis 12kg, fruit of Chinese wolfberry 2kg, Momordica grosvenori 4kg and Amomum cardamomum 1kg.
Prepare：S1, take green plum, be enucleated and rub, be subsequently adding 130kg water, temperature be 50 DEG C, microwave power be 600w Lower treatment 1.5h, filtering, filter residue add 78kg water, temperature be 50 DEG C, microwave power be 600w under process 20min, filter, close And filtrate, filtrate cools standby in vacuum-concentrcted to the medicinal extract one that relative density at 60 DEG C is 1.10；
S2, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 162kg water, soak 30min, then heated Boil, 1.5h is extracted in insulation, filtering, filter residue adds 108kg water, be incubated after boiling and extract 40min, filtering, merging filtrate, filtrate In vacuum-concentrcted to the medicinal extract two that relative density at 60 DEG C is 1.10, cool standby；
S3, the medicinal extract one and medicinal extract two are mixed, it is 65% ethanol to add 2 times of volume fractions of cream weight, is sufficiently stirred for, 24h is stood at room temperature, supernatant is taken, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtain liquid；
S4, the water toward 6 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the shitosan of 0.5g/L, Stir process 20min under 400w microwave powers, stands 6h, and filtering adds 0.1g/L preservatives toward filtrate, and filtering is after standing .
The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:0.4.
The health-care food composition of the auxiliary reducing blood lipid of embodiment 2, the present invention containing green plum and its preparation
Formula：Green plum 30kg, rhizoma imperatae 12kg, rhizoma atractylodis 16kg, fruit of Chinese wolfberry 6kg, Momordica grosvenori 8kg and Amomum cardamomum 4kg.
Prepare：S1, take green plum, be enucleated and rub, be subsequently adding 180kg water, temperature be 60 DEG C, microwave power be 800w Lower treatment 2h, filtering, filter residue add 120kg water, temperature be 60 DEG C, microwave power be 800w under process 40min, filter, close And filtrate, filtrate cools standby in vacuum-concentrcted to the medicinal extract one that relative density at 60 DEG C is 1.20；
S2, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 368kg water, soak 60min, then heated Boil, 2h is extracted in insulation, filtering, filter residue adds 276kg water, be incubated after boiling and extract 60min, filtering, merging filtrate, filtrate exists Vacuum-concentrcted is cooled standby to the medicinal extract two that relative density at 60 DEG C is 1.20；
S3, the medicinal extract one and medicinal extract two are mixed, it is 70% ethanol to add 3 times of volume fractions of cream weight, is sufficiently stirred for, 48h is stood at room temperature, supernatant is taken, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtain liquid；
S4, the water toward 8 times of liquids weights of addition in the liquid are diluted, and the shitosan of 1g/L are subsequently adding, in 500w Stir process 30min under microwave power, stands 8h, and filtering adds 0.3g/L preservatives toward filtrate, and filtering is obtained final product after standing.
The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:0.7.
The health-care food composition of the auxiliary reducing blood lipid of embodiment 3, the present invention containing green plum and its preparation
Formula：Green plum 28kg, rhizoma imperatae 10kg, rhizoma atractylodis 14kg, fruit of Chinese wolfberry 4kg, Momordica grosvenori 6kg and Amomum cardamomum 3kg.
Prepare：S1, take green plum, be enucleated and rub, be subsequently adding 140kg water, temperature be 55 DEG C, microwave power be 700w Lower treatment 1.5h, filtering, filter residue add 84kg water, temperature be 55 DEG C, microwave power be 700w under process 30min, filter, close And filtrate, filtrate cools standby in vacuum-concentrcted to the medicinal extract one that relative density at 60 DEG C is 1.10；
S2, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 259kg water, soak 40min, then heated Boil, 1.5h is extracted in insulation, filtering, filter residue adds 185kg water, be incubated after boiling and extract 50min, filtering, merging filtrate, filtrate In vacuum-concentrcted to the medicinal extract two that relative density at 60 DEG C is 1.10, cool standby；
S3, the medicinal extract one and medicinal extract two are mixed, it is 65% ethanol to add 2 times of volume fractions of cream weight, is sufficiently stirred for, 24h is stood at room temperature, supernatant is taken, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtain liquid；
S4, the water toward 7 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the shitosan of 0.8g/L, Stir process 30min under 400w microwave powers, stands 7h, and filtering adds 0.2g/L preservatives toward filtrate, and filtering is after standing .
The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:0.6.
Comparative example 1,
Formula：Green plum 28kg.
Prepare：S1, take green plum, be enucleated and rub, be subsequently adding 140kg water, temperature be 55 DEG C, microwave power be 700w Lower treatment 1.5h, filtering, filter residue add 84kg water, temperature be 55 DEG C, microwave power be 700w under process 30min, filter, close And filtrate, filtrate cools standby in vacuum-concentrcted to the medicinal extract that relative density at 60 DEG C is 1.10；
S2, it is 65% ethanol toward 2 times of volume fractions of cream weight are added in the medicinal extract, is sufficiently stirred for, stands at room temperature 24h, takes supernatant, and ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtains liquid；
S3, the water toward 7 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the shitosan of 0.8g/L, Stir process 30min under 400w microwave powers, stands 7h, and filtering adds 0.2g/L preservatives toward filtrate, and filtering is after standing .The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:0.6.
Comparative example 2,
Formula：Rhizoma imperatae 10kg, rhizoma atractylodis 14kg, fruit of Chinese wolfberry 4kg, Momordica grosvenori 6kg and Amomum cardamomum 3kg.
Prepare：S1, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 259kg water, soak 40min, so Heating afterwards is boiled, and 1.5h is extracted in insulation, and filtering, filter residue adds 185kg water, is incubated after boiling and is extracted 50min, and filtering merges filter Liquid, filtrate cools standby in vacuum-concentrcted to the medicinal extract that relative density at 60 DEG C is 1.10；
S2, it is 65% ethanol toward 2 times of volume fractions of cream weight are added in the medicinal extract, is sufficiently stirred for, stands at room temperature 24h, takes supernatant, and ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtains liquid；
S3, the water toward 7 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the shitosan of 0.8g/L, Stir process 30min under 400w microwave powers, stands 7h, and filtering adds 0.2g/L preservatives toward filtrate, and filtering is after standing .The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:0.6.
Comparative example 3,
Formula：Green plum 28kg, rhizoma imperatae 10kg, rhizoma atractylodis 14kg, fruit of Chinese wolfberry 4kg, Momordica grosvenori 6kg and Amomum cardamomum 3kg.
Prepare：S1, green plum, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 455kg water, immersion 40min, then heating is boiled, and 1.5h is extracted in insulation, and filtering, filter residue adds 325kg water, is incubated after boiling and is extracted 50min, mistake Filter, merging filtrate, filtrate cools standby in vacuum-concentrcted to the medicinal extract that relative density at 60 DEG C is 1.10；
S3, it is 65% ethanol toward 2 times of volume fractions of cream weight are added in the medicinal extract, is sufficiently stirred for, stands at room temperature 24h, takes supernatant, and ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtains liquid；
S4, the water toward 7 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the shitosan of 0.8g/L, Stir process 30min under 400w microwave powers, stands 7h, and filtering adds 0.2g/L preservatives toward filtrate, and filtering is after standing .The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:0.6.
Comparative example 4,
Compared with Example 3, the difference of this comparative example is：In preparation method step S4, do not use microwave treatment, i.e., it is past Add the water of 7 times of liquid weights to be diluted in the liquid, be subsequently adding the shitosan of 0.8g/L, stand 7h, filtering, toward filtrate Middle addition 0.2g/L preservatives, filtering is obtained final product after standing.
Comparative example 5,
Compared with Example 3, the difference of this comparative example is：In preparation method step S4, using gelatin as fining agent.
Comparative example 6,
Compared with Example 3, the difference of this comparative example is：In preparation method step S4, the preservative is phytic acid.
Comparative example 7,
Compared with Example 3, the difference of this comparative example is：In preparation method step S4, the preservative is that mushroom is more Sugar.
The safety testing of the health-care food composition of the auxiliary reducing blood lipid of test example one, the present invention containing green plum
Example 1~3 and oral liquid obtained in comparative example 1~3 carry out acute toxicity test, 30 days feeding trials respectively And feeding test for 90 days.As a result：The growing state of nutrition purposes, especially for feeding animals is good, and hematology and physico-chemical examination are normal.Therefore, the present invention is carried The oral liquid of confession has edible safety, suitable long-term consumption.
The health-care food composition of the auxiliary reducing blood lipid of test example two, the present invention containing green plum is to hyperlipidemia ratses blood fat Regulation and the influence of hepatic and renal function experiment
1st, experiment material
1.1 experimental animals
SD rats, 200 ± 20g of body weight, male, Military Medical Science Institute's medical experiment animal center breeding is provided.
1.2 experiment reagents and medicine
Embodiment 1~3, oral liquid obtained in comparative example 1~3, Simvastatin Tablets (authentication code：Chinese medicines quasi-word H20083593 manufacturers：Shanxi Yun Peng pharmaceutical Co. Ltds), cholesterol, sodium taurocholate, serum total cholesterol (TC), glycerine three Ester (TG), LDL-C (LDL-C), HDL-C (HDL-C), glutamic-pyruvic transaminase (ALT), paddy Careless transaminase (AST), blood creatinine (Cr), urea nitrogen (BUN) determine kit.
2nd, experimental technique
2.1 rearing conditions
Zoopery room air timing air draft, illumination are good, normal temperature.10 animals are raised per cage, is raised with conventional expanded feeding Material, free water.Before on-test, the feed of observation animal, activity and excrement etc. 1 week, selection healthy animal enters experiment.
The packet of 2.2 experimental animals
Healthy male SD rat 80, is randomly divided into 10 groups, every group 8：Blank control group, model control group, pungent cut down him Spit of fland group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example and combined therapy Group.Blank control group rat normal diet, other groups use olive Antihyperlipidemia capsule.
2.2 hyperlipemia model of rats are prepared and are administered
Hyperlipemia model of rats causes hyperlipidemia method using high lipid food.High lipid food formula is as follows：Basal feed 86.3%th, cholesterol 3%, lard 10%, methylthiouracil 0.2%, Pig cholate 0.5%, it is ensured that each composition is well mixed.Even 14 days high lipid foods of continuous feeding.High lipid food is given between administration phase every other day.
The method of administration of clinical plan is oral, therefore this experiment is administered using administration by gavage.14 days high lipid foods of continuous feeding Afterwards, gastric infusion is started within the 15th day, continuous gavage is administered 20 days, gavage is carried out after animal is taken food.Each group gives down respectively State test medicine：
Blank control group：Normal diet, is not administered；
Model control group：Gavage gives physiological saline 40.0mg/ (kgd)；
Simvastatin group：Gavage gives Simvastatin 0.18mg/ (kgd)；
1 group of embodiment：Gavage gives oral liquid 40.0ml/ (kgd) obtained in the embodiment of the present invention 1；
2 groups of embodiment：Gavage gives oral liquid 40.0ml/ (kgd) obtained in the embodiment of the present invention 2；
3 groups of embodiment：Gavage gives oral liquid 40.0ml/ (kgd) obtained in the embodiment of the present invention 3；
1 group of comparative example：Gavage gives oral liquid 40.0ml/ (kgd) obtained in comparative example of the present invention 1；
2 groups of comparative example：Gavage gives oral liquid 40.0ml/ (kgd) obtained in comparative example of the present invention 2；
3 groups of comparative example：Gavage gives oral liquid 40.0ml/ (kgd) obtained in comparative example of the present invention 3；
Combined therapy group：Gavage gives Simvastatin 0.18mg/ (kgd), and gavage gives the embodiment of the present invention 3 after 0.5h Obtained oral liquid 40.0ml/ (kgd)；
3rd, Testing index
After rat oral gavage is administered 20 days, from the 21st day, chloraldurate 400mg/kg body weight was used in fasting 24 hours before experiment Standard dose is anaesthetized through rat abdominal cavity, shaving, opens thoracic cavity, exposes heart, the ventricle blood sampling 7ml to the right at the apex of the heart, in normal temperature Lower 3000rpm is centrifuged 15 minutes, separates the index that serum determines TC, TG, HDL, LDL, ALT, AST, Cr and BUN in serum.
Lipid determination：Determine serum TG, TC, HDL, LDL；Liver functional testing：ALT、AST；Renal function is determined：Cr、BUN.
4th, result of the test：
(1) to the influence of olive Antihyperlipidemia capsule TG, TC
Table 1
Group TG(mmol/L) TC(mmol/L)
Blank control group 0.495±0.082 1.713±0.240
Model control group 1.126±0.163** 2.280±0.376**
Simvastatin group
1 group of embodiment
2 groups of embodiment
3 groups of embodiment
1 group of comparative example 1.084±0.147 2.169±0.362
2 groups of comparative example 1.124±0.158 2.276±0.402
3 groups of comparative example 1.021±0.103 2.091±0.349
Combined therapy group
* P compared with blank control group<0.01；#The P compared with model control group<0.05,##The P compared with model control group< 0.01。
From upper table 1：Model control group rat TG and TC content is apparently higher than blank control group (P<0.01), it was demonstrated that high Blood fat rat model modeling success；TG the and TC contents of Simvastatin group and combined therapy group are significantly lower than model group (P< 0.01), it was demonstrated that treatment is effective, and TG the and TC contents of combined therapy group are lower, close to normal mouse；1~3 group of embodiment is to height TG the and TC contents of blood fat rat model have obvious reduction effect (P<0.05), wherein most bright with the effect of 3 groups of embodiment It is aobvious；3 groups of 1 group of comparative example and comparative example have certain reduction to act on to rat model TG and TC content, but not substantially, also than implementing The effect of example 1~3 is poor, and 2 groups of comparative example does not work substantially.
(2) to the influence of olive Antihyperlipidemia capsule HDL, LDL
Table 2
Group HDL(mmol/L) LDL(mmol/L)
Blank control group 1.227±0.096 0.846±0.174
Model control group 0.832±0.065** 1.542±0.168**
Simvastatin group
1 group of embodiment 1.368±0.190
2 groups of embodiment 1.379±0.174
3 groups of embodiment
1 group of comparative example 0.855±0.097 1.403±0.180
2 groups of comparative example 0.830±0.080 1.539±0.173
3 groups of comparative example 0.866±0.099 1.407±0.188
Combined therapy group
* P compared with blank control group<0.01；#The P compared with model control group<0.05,##The P compared with model control group< 0.01。
From upper table 2：Model control group rat HDL contents are significantly lower than blank control group (P<0.01), LDL contents are bright Aobvious is higher than blank control group (P<0.01), it was demonstrated that Arteriosclerosis rat model modeling success；Simvastatin group and combined therapy group HDL contents are apparently higher than model control group (P<0.01), LDL contents are significantly lower than model control group (P<0.01), it was demonstrated that treatment Effectively, and combined therapy group therapeutic effect more preferably；1~3 group of HDL content to Arteriosclerosis rat model of embodiment has rising to make With, there is reduction to act on LDL contents, wherein most obvious with the effect of 3 groups of embodiment, statistical procedures have significant difference (P< 0.05)；3 groups of 1 group of comparative example and comparative example have certain adjustment effect to rat model HDL and LDL content, but not substantially, Effect than embodiment 1~3 is poor, and 2 groups of comparative example does not work substantially.
(3) to the influence of olive Antihyperlipidemia capsule ALT, AST
Table 3
Group ALT(mmol/L) AST(mmol/L)
Blank control group 17.70±2.259 20.50±3.270
Model control group 38.10±3.862** 35.80±4.532**
Simvastatin group 48.60±4.592** 53.40±3.806**
1 group of embodiment
2 groups of embodiment
3 groups of embodiment 22.50±3.107##
1 group of comparative example 35.20±3.752 32.90±4.081
2 groups of comparative example 37.40±3.809 43.70±3.894
3 groups of comparative example 31.80±3.732 29.10±3.945
Combined therapy group 24.00±2.963## 25.70±3.972##
* P compared with blank control group<0.01；## P compared with model control group<0.01.
From upper table 3：Model control group ALT and AST content are apparently higher than blank control group (P<0.01), illustrate in height In the case of diet, easily increase burden of liver, cause hepar damnification, dysfunction of liver occur；Simvastatin group ALT and AST Content is apparently higher than blank control group (P<0.01), it was demonstrated that Simvastatin has damage to liver function；1~3 group of embodiment and group Close treatment group ALT and AST content and be significantly lower than model control group (P<0.01), close to blank control group, illustrate embodiment 1~ 3 groups of composition oral liquid play a very good protection to liver, and when coordinating Simvastatin to take, can effectively slow down pungent cutting down Damage of the statin to liver；3 groups of 1 group of comparative example and comparative example have and have certain protective effect to liver, and 2 groups of comparative example is substantially not Work.
(4) to the influence of olive Antihyperlipidemia capsule Cr, BUN
Table 4
Group Cr(mmol/L) BUN(mmol/L)
Blank control group 30.334±2.815 5.894±1.095
Model control group 31.647±2.473 6.143±0.984
Simvastatin group 32.364±2.490 6.245±1.104
1 group of embodiment 30.792±2.506 6.013±1.090
2 groups of embodiment 31.073±2.125 6.071±1.103
3 groups of embodiment 30.390±1.809 5.947±1.008
Combined therapy group 30.408±1.972 5.908±1.012
From upper table 4：Compare between each group, no significant difference, in the case of illustrating high fat diet, to kidney in the short time The influence of dirty function is not obvious.Simvastatin is taken with the preceding no significant difference for the treatment of, the composition oral of the embodiment of the present invention 1~3 While liquid regulation blood fat, renal function is had not significant impact.
The long-term stable experiment of the health-care food composition of the auxiliary reducing blood lipid of test example three, the present invention containing green plum
To embodiment 1~3, oral liquid carries out long-term stable experiment at room temperature obtained in comparative example 4~7, as a result sees Table 5 below and table 6.
Table 5
Table 6
From upper table 5：The health-care food composition oral liquid of auxiliary reducing blood lipid of the embodiment of the present invention 1~3 containing green plum Stable system, by 12 months long-term stable experiments, not there is brown stain in product colour, also not precipitate generation, product Local flavor does not change, and pH value is constant, and microorganism limitation meets regulation.
From upper table 6：Microwave treatment is not used in the preparation of the oral liquid of comparative example 4, causes resin, the mucilaginous substance of indissoluble Isocolloid material cannot be removed, so that product taste slight bitter, begins with precipitation and produce after placing 3 months, and pH value declines, shadow Ring product special flavour and outward appearance；Using gelatin as fining agent in the preparation of the oral liquid of comparative example 5, but it is clear with what microwave coordinated Clear effect is undesirable, it is impossible to remove resin, the mucilaginous substance isocolloid material of indissoluble, so that product taste slight bitter, puckery, placement 3 A small amount of precipitation is begun with after month to produce, and pH value declines；Comparative example 6 uses phytic acid as preservative, and comparative example 7 is using fragrant Mushroom polysaccharide is used as preservative, and its antiseptic effect is undesirable, product occur different degrees of brown stain, acidifying, and bacterium and Fungi showed increased, illustrating that phytic acid and lentinan are applied in combination can Synergistic antimicrobial anti-corrosion.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe The personage for knowing this technology all can carry out modifications and changes under without prejudice to spirit and scope of the invention to above-described embodiment.Cause This, those of ordinary skill in the art is complete with institute under technological thought without departing from disclosed spirit such as Into all equivalent modifications or change, should be covered by claim of the invention.

Claims (4)

1. it is a kind of containing green plum auxiliary reducing blood lipid health-care food composition preparation method, it is characterised in that including following step Suddenly：
S1, green plum is taken, be enucleated and rub, be subsequently adding 5~6 times of water of amount of green plum weight, be 50~60 DEG C, microwave work(in temperature Rate is 1.5~2h for the treatment of under 600~800w, and filtering, filter residue adds 3~4 times of water of amount of green plum weight, is 50~60 in temperature DEG C, microwave power be 600~800w under process 20~40min, filtering, merging filtrate, filtrate is in vacuum-concentrcted to 60 DEG C Lower relative density is 1.10~1.20 medicinal extract one, is cooled standby；
S2, rhizoma imperatae, rhizoma atractylodis, the fruit of Chinese wolfberry, Momordica grosvenori and Amomum cardamomum are taken, add 6~8 times of water of amount of inventory, immersion 30~ 60min, then heating is boiled, and 1.5~2h, filtering are extracted in insulation, and filter residue adds 4~6 times of water of amount of inventory, is incubated after boiling 40~60min is extracted, is filtered, merging filtrate, filtrate is 1.10~1.20 in vacuum-concentrcted to relative density at 60 DEG C Medicinal extract two, cools standby；
S3, the medicinal extract one and medicinal extract two are mixed, it is 65~70% ethanol to add 2~3 times of volume fractions of cream weight, is fully stirred Mix, 24~48h is stood at room temperature, take supernatant, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtain liquid；
S4, the water toward 6~8 times of liquids weights of addition in the liquid are diluted, and are subsequently adding the fining agent of 0.5~1g/L, 20~30min of stir process under 400~500w microwave powers, stands 6~8h, and filtering adds 0.1~0.3g/L to prevent toward filtrate Rotten agent, filtering is obtained final product after standing；
In the health-care food composition of the auxiliary reducing blood lipid containing green plum, the weight portion of each preparing raw material is as follows：Green plum 26~ 1~4 part of 30 parts, 8~12 parts of rhizoma imperatae, 12~16 parts of rhizoma atractylodis, 2~6 parts of the fruit of Chinese wolfberry, 4~8 parts of Momordica grosvenori and Amomum cardamomum；
The health-care food composition of the auxiliary reducing blood lipid containing green plum is oral liquid.
2. the preparation method of the health-care food composition of the auxiliary reducing blood lipid of green plum is contained as claimed in claim 1, it is characterised in that In the health-care food composition of the auxiliary reducing blood lipid containing green plum, the weight portion of each preparing raw material is as follows：28 parts of green plum, cogongrass 3 parts of 10 parts of root, 14 parts of rhizoma atractylodis, 4 parts of the fruit of Chinese wolfberry, 6 parts of Momordica grosvenori and Amomum cardamomum.
3. the preparation method of the health-care food composition of the auxiliary reducing blood lipid of green plum is contained as claimed in claim 1, it is characterised in that The fining agent is shitosan.
4. the preparation method of the health-care food composition of the auxiliary reducing blood lipid of green plum is contained as claimed in claim 1, it is characterised in that The preservative is the mixture of phytic acid and lentinan, and the weight ratio of the phytic acid and lentinan is 1:(0.4~0.7).
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