CN107213391A - One kind has strengthening spleen and nourishing stomach, and help digestion pharmaceutical composition of tune fat and preparation method thereof - Google Patents
One kind has strengthening spleen and nourishing stomach, and help digestion pharmaceutical composition of tune fat and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
There is strengthening spleen and nourishing stomach the invention discloses one kind, help digestion pharmaceutical composition of tune fat and preparation method thereof, described pharmaceutical composition is by following components and weight ratio composition：The parts by weight of melanoidin malt 8 100, the parts by weight of red yeast rice 8 100, the parts by weight of Semen Lablab Album 8 100, the parts by weight of lotus leaf 8 100, the parts by weight of cassia seed 8 100, the parts by weight of the membrane of a chicken's gizzard 3 80, the parts by weight of citron 3 80, the parts by weight of charred FRUCTUS CRATAEGI 3 80.Pharmaceutical composition composition of the present invention is simple, novel formula, with strengthening spleen and nourishing stomach, helps digestion and adjusts the effect of fat, there is preferably prevention or therapeutic effect to eating accumulation or hyperlipidemia.
Description
Technical field
The invention belongs to drug field, the present invention relates to a kind of pharmaceutical composition with treatment or health-care efficacy, especially
It is to be related to one kind there is strengthening spleen and nourishing stomach, the pharmaceutical composition and preparation method of the effect for adjusting fat that helps digestion.
Background technology
In recent years, with the improvement of people ' s living standards and rhythm of life quickening, people, which eat and drink immoderately, makes stomach and intestine extremely
Injury, current clinical practice is many in the medicine for promoting to digest, but the effect of these kinds is more single, and is inconvenient to take.Example
Such as promoting digestion medicine domperidone has promotion gastrointestinal motility, promotes the effect of digestion, but without the effect of regulation blood fat；Reducing blood lipid
Common medicine Simvastatin plays the role of to adjust blood fat, but can not improve digestive function.If it is desired to improve digestive function and adjust
Blood fat is it is necessary to while take multi-medicament.And these Drug safeties are under suspicion, domperidone may cause the rhythm of the heart to lose
Often, the adverse events such as heart arrest, sudden death；And simvastatin can cause constipation, flatulence shows that its digestive function has pair
Effect.Chinese medicine compound prescription can solve problem above well just.Chinese medicine compound prescription is integrated by each active ingredient and played a role, to many
Planting disease has therapeutic effect.Our people uses some Chinese medicines for a long time in diet, and these Chinese medicines are in use
Demonstrate its security.National drug food Surveillance Authority (abbreviation CFDA) also discloses integration of drinking and medicinal herbs, can be used for health care
The Chinese medicine list of food, shows that CDFA is recognized these Drug safeties.The present invention is exactly that the medicine food for selecting CDFA to announce is same
Source, the Chinese medicine that can be used in the Chinese medicine list of health food, by reasonable compatibility, reaches strengthening spleen and nourishing stomach, and help digestion Regulation serum lipids,
Its security has obtained CFDA accreditations simultaneously, very safe.
The content of the invention
It is an object of the invention to solve the deficiencies in the prior art to constitute simply, and by natural medicinal raw material there is provided one kind
Active ingredient or the extract combination of active ingredient of its medicinal raw material there is strengthening spleen and nourishing stomach, help digestion and adjust fat
Pharmaceutical composition.The pharmaceutical composition has good effect, has no toxic side effect, and is not likely to produce tolerance, convenient to take, is generally applicable
In indigestion, hyperlipidemia patient.
It is another object of the present invention to provide a kind of preparation method of pharmaceutical composition and purposes.
The purpose of the present invention is achieved through the following technical solutions：One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the medicine of fat
Compositions, it is characterised in that：It is made up of following components and weight ratio：Melanoidin malt 8-100 parts by weight, red yeast rice 8-100 weights
Part is measured, Semen Lablab Album 8-100 parts by weight, lotus leaf 8-100 parts by weight, cassia seed 8-100 parts by weight, the membrane of a chicken's gizzard 3-80 parts by weight are fragrant
Rafter 3-80 parts by weight, charred FRUCTUS CRATAEGI 3-80 parts by weight.
Preferably, melanoidin malt 10-80 parts by weight, red yeast rice 10-80 parts by weight, Semen Lablab Album 10-80 parts by weight, lotus leaf 10-80
Parts by weight, cassia seed 10-80 parts by weight, the membrane of a chicken's gizzard 5-60 parts by weight, citron 5-60 parts by weight, charred FRUCTUS CRATAEGI 5-60 parts by weight.
Preferably, melanoidin malt 20-60 parts by weight, red yeast rice 20-60 parts by weight, Semen Lablab Album 20-60 parts by weight, lotus leaf 20-60
Parts by weight, cassia seed 20-60 parts by weight, the membrane of a chicken's gizzard 10-50 parts by weight, citron 10-50 parts by weight, charred FRUCTUS CRATAEGI 10-50 parts by weight.
Preferably, melanoidin malt 30-50 parts by weight, red yeast rice 30-50 parts by weight, Semen Lablab Album 30-50 parts by weight, lotus leaf 30-50
Parts by weight, cassia seed 30-50 parts by weight, the membrane of a chicken's gizzard 15-40 parts by weight, citron 15-40 parts by weight, charred FRUCTUS CRATAEGI 15-40 parts by weight.
Preferably, the parts by weight of melanoidin malt 40, the parts by weight of red yeast rice 40, the parts by weight of Semen Lablab Album 40, the parts by weight of lotus leaf 40, cassia seed
40 parts by weight, the parts by weight of the membrane of a chicken's gizzard 20, the parts by weight of citron 20, the parts by weight of charred FRUCTUS CRATAEGI 20.
Preferably, the parts by weight of melanoidin malt 15, the parts by weight of red yeast rice 15, the parts by weight of Semen Lablab Album 15, the parts by weight of lotus leaf 10, cassia seed
15 parts by weight, the parts by weight of the membrane of a chicken's gizzard 5, the parts by weight of citron 6, the parts by weight of charred FRUCTUS CRATAEGI 5.
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Fructus Hordei Germinatus extract 8-100 parts by weight, red yeast rice 8-100 extract weights part, Semen Lablab Album extract 8-100 parts by weight,
Lotus Leafextract 8-100 parts by weight, cassia seed extract 8-100 parts by weight, Endothelium Corneum Gigeriae Galli extract 3-80 parts by weight, citron is extracted
Thing 3-80 parts by weight, Fructus Crataegi (parched to brown) extract 3-80 parts by weight.
Preferably, the parts by weight of Fructus Hordei Germinatus extract 15, the extract weight part of red yeast rice 15, the parts by weight of Semen Lablab Album extract 15,
The parts by weight of Lotus Leafextract 10, the parts by weight of cassia seed extract 15, the parts by weight of Endothelium Corneum Gigeriae Galli extract 5, the weight of citron extract 6
Part, the parts by weight of Fructus Crataegi (parched to brown) extract 5.
A kind of method for preparing any of the above-described pharmaceutical composition, this method comprises the following steps：S1：Jiao is weighed by weight
Malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron, charred FRUCTUS CRATAEGI；S2：Medicine is prepared into according to customary preparation methods
Composition.
The pharmaceutical composition of the present invention can be prepared into institute in any pharmacy according to the conventional method of pharmaceutical field
The formulation stated；The pharmaceutical composition of the present invention can be applied to patient by way of oral, suction or parenteral administration.Orally give
Piece agent, capsule, pill, pulvis, granule, syrup or oral liquid etc. can be prepared during medicine；It can be made in parenteral administration
It is standby into freeze-dried powder and parenteral solution etc..
To enable above-mentioned formulation to realize, pharmaceutically acceptable auxiliary material need to be added when preparing these formulations, for example：Filling
Agent, disintegrant, lubricant, suspending agent, adhesive, sweetener, flavouring, preservative etc., filler includes：Starch, pregelatinated
Starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose etc., disintegrant includes：Starch, pregelatinized starch, microcrystalline cellulose
Element, sodium carboxymethyl starch, PVPP, low-substituted hydroxypropyl cellulose, Ac-Di-Sol etc., lubrication
Agent includes：Magnesium stearate, lauryl sodium sulfate, talcum powder, silica etc., suspending agent includes：It is polyvinylpyrrolidone, micro-
Crystalline cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc., adhesive includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl
Methylcellulose etc., sweetener includes：Saccharin sodium, aspartame, sucrose, honey element, enoxolone etc., flavouring includes：Sweet tea
Taste agent and various essence, preservative include：Parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, vinegar
Sour chloroethene is fixed, eucalyptus oil etc..
The beneficial effects of the invention are as follows：Being experimentally confirmed this pharmaceutical composition has strengthening spleen and nourishing stomach, promotes animal ingestion,
Promote small bowel peristalsis function and gastric emptying, improve digestive function, increase the weight of animals.Meanwhile, pharmaceutical composition of the present invention can be with
Reduce TC, TG, LDL-C content in blood and liver, HDL-C contents rise, liver index declines, and further relates to the present invention
Pharmaceutical composition can adjust blood fat, have certain effect to anti-curing hyperlipemia.
Embodiment
Technical scheme is described in further detail with reference to embodiment, but protection scope of the present invention is not limited to
In as described below.
Embodiment 1：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 8g, red yeast rice 8g, Semen Lablab Album 8g, lotus leaf 8g, cassia seed 8g, the membrane of a chicken's gizzard 3g, citron 3g, charred FRUCTUS CRATAEGI 3g.
Embodiment 2：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 100g, red yeast rice 100g, Semen Lablab Album 100g, lotus leaf 100g, cassia seed 100g, the membrane of a chicken's gizzard 80g, citron 80g,
Charred FRUCTUS CRATAEGI 80g.
Embodiment 3：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 10g, red yeast rice 10g, Semen Lablab Album 10g, lotus leaf 10g, cassia seed 10g, the membrane of a chicken's gizzard 5g, citron 5g, charred FRUCTUS CRATAEGI
5g。
Embodiment 4：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 20g, red yeast rice 20g, Semen Lablab Album 20g, lotus leaf 20g, cassia seed 20g, the membrane of a chicken's gizzard 10g, citron 10g, charred FRUCTUS CRATAEGI
10g。
Embodiment 5：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 60g, red yeast rice 60g, Semen Lablab Album 60g, lotus leaf 60g, cassia seed 60g, the membrane of a chicken's gizzard 10g, citron 10g, charred FRUCTUS CRATAEGI
10g。
Embodiment 6：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 30g, red yeast rice 30g, Semen Lablab Album 30g, lotus leaf 30g, cassia seed 30g, the membrane of a chicken's gizzard 15g, citron 15g, charred FRUCTUS CRATAEGI
15g。
Embodiment 7：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 50g, red yeast rice 50g, Semen Lablab Album 50g, lotus leaf 50g, cassia seed 50g, the membrane of a chicken's gizzard 40g, citron 40g, charred FRUCTUS CRATAEGI
40g。
Embodiment 8：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 40g, red yeast rice 40g, Semen Lablab Album 40g, lotus leaf 40g, cassia seed 40g, the membrane of a chicken's gizzard 20g, citron 20g, charred FRUCTUS CRATAEGI
20g。
Embodiment 9：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 15g, red yeast rice 15g, Semen Lablab Album 15g, lotus leaf 10g, cassia seed 15g, the membrane of a chicken's gizzard 5g, citron 6g, charred FRUCTUS CRATAEGI
5g。
Embodiment 10：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：In Fructus Hordei Germinatus extract 8g, red yeast rice 8g, Semen Lablab Album extract 8g, Lotus Leafextract 8g, cassia seed extract 8g, chicken
Golden extract 3g, citron extract 3g, Fructus Crataegi (parched to brown) extract 3g.
Embodiment 11：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Fructus Hordei Germinatus extract 100g, red yeast rice 100g, Semen Lablab Album extract 100g, Lotus Leafextract 100g, cassia seed extract
100g, Endothelium Corneum Gigeriae Galli extract 80g, citron extract 80g, Fructus Crataegi (parched to brown) extract 80g.
Embodiment 11：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Fructus Hordei Germinatus extract 15g, Red Yeast Rice P.E 15g, Semen Lablab Album extract 15g, Lotus Leafextract 10g, cassia seed are extracted
Thing 15g, Endothelium Corneum Gigeriae Galli extract 5g, citron extract 6g, Fructus Crataegi (parched to brown) extract 5g.
Embodiment 12：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 8g, red yeast rice 8g, Semen Lablab Album 8g, lotus leaf 8g, cassia seed 8g, the membrane of a chicken's gizzard 3g, citron 3g, charred FRUCTUS CRATAEGI 3g, according to
Conventional method is prepared into pulvis.
Embodiment 13：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 100g, red yeast rice 100, Semen Lablab Album 100g, lotus leaf 100g, cassia seed 100g, the membrane of a chicken's gizzard 80g, citron 80g are burnt
Hawthorn 80g, is conventionally prepared into granule.
Embodiment 14：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 10g, red yeast rice 10g, Semen Lablab Album 10g, lotus leaf 10g, cassia seed 10g, the membrane of a chicken's gizzard 5g, citron 5g, charred FRUCTUS CRATAEGI
5g, is conventionally prepared into lotion.
Embodiment 15：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 20g, red yeast rice 20g, Semen Lablab Album 20g, lotus leaf 20g, cassia seed 20g, the membrane of a chicken's gizzard 10g, citron 10g, charred FRUCTUS CRATAEGI
10g, is conventionally prepared into oral liquid.
Embodiment 16：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 60g, red yeast rice 60g, Semen Lablab Album 60g, lotus leaf 60g, cassia seed 60g, the membrane of a chicken's gizzard 10g, citron 10g, charred FRUCTUS CRATAEGI
10g, is conventionally prepared into capsule.
Embodiment 17：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 30g, red yeast rice 30g, Semen Lablab Album 30g, lotus leaf 30g, cassia seed 30g, the membrane of a chicken's gizzard 15g, citron 15g, charred FRUCTUS CRATAEGI
15g, conventionally prepares piece agent.
Embodiment 18：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 50g, red yeast rice 50g, Semen Lablab Album 50g, lotus leaf 50g, cassia seed 50g, the membrane of a chicken's gizzard 40g, citron 40g, charred FRUCTUS CRATAEGI
40g, is conventionally prepared into granule.
Embodiment 19：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 40g, red yeast rice 40g, Semen Lablab Album 40g, lotus leaf 40g, cassia seed 40g, the membrane of a chicken's gizzard 20g, citron 20g, charred FRUCTUS CRATAEGI
20g, is conventionally prepared into injection.
Embodiment 20：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Melanoidin malt 15g, red yeast rice 15g, Semen Lablab Album 15g, lotus leaf 10g, cassia seed 15g, the membrane of a chicken's gizzard 5g, citron 6g, charred FRUCTUS CRATAEGI
5g, conventionally prepares paste making agent.
Embodiment 21：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：In Fructus Hordei Germinatus extract 8g, red yeast rice 8g, Semen Lablab Album extract 8g, Lotus Leafextract 8g, cassia seed extract 8g, chicken
Golden extract 3g, citron extract 3g, Fructus Crataegi (parched to brown) extract 3g, is conventionally prepared into effervescent agent.
Embodiment 22：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Fructus Hordei Germinatus extract 100g, red yeast rice 100g, Semen Lablab Album extract 100g, Lotus Leafextract 100g, cassia seed extract
100g, Endothelium Corneum Gigeriae Galli extract 80g, citron extract 80g, Fructus Crataegi (parched to brown) extract 80g, are conventionally prepared into pill.
Embodiment 23：
One kind has strengthening spleen and nourishing stomach, helps digestion and adjusts the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight
Than composition：Fructus Hordei Germinatus extract 15g, Red Yeast Rice P.E 15g, Semen Lablab Album extract 15g, Lotus Leafextract 10g, cassia seed are extracted
Thing 15g, Endothelium Corneum Gigeriae Galli extract 5g, citron extract 6g, Fructus Crataegi (parched to brown) extract 5g, conventionally prepare piece agent.
Medicine extracting method：Charred FRUCTUS CRATAEGI medicinal material powder, plus 10 times of 70% alcohol refluxs of amount is taken to extract 2 times, each 1h will be extracted
Thing is filtered, merging filtrate；Filtrate recycling ethanol is to without alcohol taste.Charred FRUCTUS CRATAEGI medicinal material powder, plus 6 times of amount water are taken, are decocted 2 times, each 2h,
Extract is filtered, merging obtains filtrate.Melanoidin malt medicinal material powder, plus 8 times of amount water are taken, are decocted 2 times, each 1h, by extract mistake
Filter, merging obtains filtrate.Take Semen Lablab Album medicinal material powder, plus 8 times of 95% alcohol refluxs of amount to extract 2h, extract is filtered, second is reclaimed
Alcohol is to without alcohol taste.Take lotus leaf medicinal material powder, plus 5 times of amount decoctings to boil 4h, filter, centrifugation is concentrated in vacuo to 50mL.Take lotus leaf medicinal material
Powder, plus 10 times of 70% alcohol refluxs of amount extract 4h, filter, and centrifugation is concentrated in vacuo to 50mL.Depend on pine torch medicinal material powder, plus 8 times of amounts
Concentration is extracted 2 times for 50% alcohol reflux, and each 2h filters extract, merging filtrate；Filtrate recycling ethanol is to without alcohol
Taste.The membrane of a chicken's gizzard coarse powder, plus 6 times of amount water are taken, 85 DEG C are extracted 2 times, each 1h.Citron medicinal material powder is taken, supercritical CO is added2Fluid extracts
Take in pond, 40 DEG C of abstraction pool temperature, 30 DEG C of reception tank temperature, first static extracting 45min, then dynamic extraction 20min；CO2Flow
1.5mL/min, obtains extract.Merge alcohol extract and Aqueous extracts, adjust to every 100 milliliters equivalent to 5 parts of charred FRUCTUS CRATAEGI, melanoidin malt
15 parts, 15 parts of Semen Lablab Album, 10 parts of lotus leaf, 15 parts of cassia seed, 5 parts of the membrane of a chicken's gizzard, 6 parts of citron.After the mixing of said extracted liquid, add red
15 parts of starter powder, by being concentrated and dried, is made medicinal extract.Per 1g medicinal extract equivalent to crude drug 3g.
For charred FRUCTUS CRATAEGI, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron extract extractant can
To be water, alcohol, hexane or its mixture.Extract of the present invention can using concussion extraction, surname extraction, refluxing extraction or
Ultrasonic extraction is extracted, but is not limited to these methods.For Extracting temperature, preferably 40-100 DEG C, and for temperature, it is optimal
Elect 60-95 DEG C as.In addition, being 1-5 times for extracting duration, preferably 2-24h, and extraction time.In addition, Jiaoshan Hill
Short, bristly hair or beard, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron extract can be used or logical by being bought from market
Cross organic synthesis acquisition.
Comprising charred FRUCTUS CRATAEGI, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron extract be used for invigorating the spleen
Nourishing the stomach, helps digestion and adjusts the pharmaceutical composition of fat to can be formulated as solid pharmaceutical preparation such as tablet, pill, pulvis, granule, capsule etc., uses
In orally administering.These solid pharmaceutical preparations can be by that will contain charred FRUCTUS CRATAEGI, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, chicken
Interior gold, citron extract mix to prepare with least one excipient such as starch, calcium carbonate, sucrose or lactose, gelatin etc..This
Outside, pharmaceutical composition can be formulated as liquid preparation, such as supensoid agent, for interior liquid, emulsion, syrup, for oral
Using.In addition to water and atoleine, various excipient such as NMF, sweetener, aromatic, preservative etc. can be used for preparing
Liquid preparation.
In addition, when being formulated for parenteral administration, including charred FRUCTUS CRATAEGI, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, Cassia
Son, the membrane of a chicken's gizzard, citron extract are used for strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat can be comprising aseptic aqueous solution, non-
Aqueous solvent, suspension, emulsion, lyophilized formulations and suppository.Nonaqueous solvents and suspension can be propane diols, polyethylene glycol, plant
Oil such as olive oil, or injectable esters such as ethyl oleate.The basic material of suppository can be polyethylene glycol, Tween61, cacao butter,
Glycerin gelatine etc..Method of administration can be any general way, as long as it reaches target tissue.Method of administration can be oral, abdomen
Film is interior, intravenous, in intramuscular, subcutaneous, intranasal, intrapulmonary, rectum, intracavitary, intraperitoneal and intrathecal, but be not limited to these.For example,
Pharmaceutical composition can pass through oral, rectum or vein, muscle, subcutaneous, endometrium or ICV drug administration by injection.Include Jiao
Hawthorn, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron extract be used for strengthening spleen and nourishing stomach, help digestion tune fat
The pharmaceutical composition of present disclosure can be administered once a day or be divided at regular intervals several times.In addition, comprising charred FRUCTUS CRATAEGI,
Melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron extract be used for strengthening spleen and nourishing stomach, help digestion adjust fat this public affairs
Opening the pharmaceutical composition of content can further include to promoting to digest, and regulation blood fat has the other active components of effect.Bag
Containing charred FRUCTUS CRATAEGI, melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, the present disclosure of citron extract medicine group
Compound can be used alone or is used in combination with multiple therapy methods such as medicinal treatment, acupuncture and moxibustion treatment etc., with strengthening spleen and nourishing stomach, help digestion
Adjust fat.
Beneficial effects of the present invention are proved below by specific pharmacy test：
1. improve digestion experiment
Healthy SD rat (body weight 180~200g, SPF grade, male and female half and half), modeling after adaptability is raised one week.Animal fills
Stomach rheum officinale decocting liquid modeling.The daily gavage of every animal once, each 4mL, continuous 10 days.The 3rd day animal of gavage starts to occur
Loose stool, and it is continued until that modeling terminates.Dietary amount is significantly reduced after 3rd day.Occur within 5th day becoming thin, weight loss, crissum is dirty
Dirty, there is prolapse of the anus in Some Animals.9th, there is weakness of limbs in most animals after 10 days, and into shape of crawling, slow movement, reaction is slow
Blunt, even taking action for having is crooked, and hair is withered, evacuation.Animal with these symptom and signs is considered as modeling success.
The selection successful animal of modeling is randomly divided into 4 groups：Model group, basic, normal, high dosage group, every group 10, male and female are each
Half.Separately 10 rats are taken as normal group, male and female half and half, not modeling.
Blank control group and model control group give drinking water；Basic, normal, high dosage group give respectively 2g/kg, 4g/kg,
This pharmaceutical composition of 8g/kg.Each group is administered by gavage mode, gavage volume 1mL/100g, once a day, the 7th after modeling
It is started medication, continued administration 14d.Administration determines the weight of animals and food ration in D1 days and D14 days.Animal ingestion amount is determined：Head
Give certain feed in the morning on the one, and the ratio of surplus, both differences and animal numbers is determined to morning next day time to approach
The as average food ration of animal.
Table 1 is to deficiency of spleen-QI and stomach-QI indigestion rat appetite, the influence (± SD) of weight
*：Compared with model control group, P ＜ 0.05**：Compared with model control group, P ＜ 0.01
Influence of the table 2 to deficiency of spleen-QI and stomach-QI indigestion rat food ration
When experiment starts, compared with blank control group, model group and basic, normal, high dosage group the weight of animals are relatively low, and difference has
Statistical significance.Modeling animal starts on the 6th day to occur that diet declines, dilute soft, hair of defecating is withered, movable frequency declines in modeling
Etc. indigestion performance.After administration, each dosage group animal body quality rises, compared with model control group, middle and high dosage group animal
Weight difference is statistically significant.Animal ingestion amount increase after administration, stool shaping, hair recovers normal, activity increase, says
Bright pharmaceutical composition energy strengthening spleen and nourishing stomach, promotes animal ingestion, improves digestive function, puts on weight.
Gastrointestinal motility function index determining：Last dose after modeling the 13rd day, animal fasting (free water) 12h.Administration
After 1h, each group gavage carbon powder nutrition semisolid paste, volume 0.4mL/ only, weighs the quality of 0.4mL carbon powders nutrition semisolid paste.
Neck is taken off after 20min and puts to death animal, is cut open the belly, mesenterium is separated, ligation stomach orifice of the stomach, pylorus take stomach and small intestine.Stomach with filter paper wipe it is dry after
Weigh, body of stomach is cut off along greater curvature, wash away and wipe dry after gastric content, claim net weight.Using stomach full weight and the difference of net weight to be residual in stomach
The quality of thing is stayed, the percentage that residue quality in stomach accounts for filled carbon powder nutrition semisolid paste quality is calculated, is as remained in stomach
Rate (%).Small intestine is taken out, using pylorus as starting point, distance and the total length of small intestine that measurement black paste thing is promoted calculate charcoal
The distance of last small intestine push accounts for the percentage of total small intestinal length, as Intestinal propulsive rate (%).Residual rate (%) in stomach=(stomach is complete
Quality-the net quality of stomach)/fill carbon powder semisolid paste quality × 100%.Intestinal propulsive rate (%)=(carbon powder semisolid paste is small
Enteral promotes length/mouse small intestine overall length) × 100%.
Influence (± SD) of the table 3 to solid residue rate in deficiency of spleen-QI and stomach-QI indigestion rat small intestine propulsion rate and stomach
*：Compared with model control group, P ＜ 0.05**：Compared with model control group, P ＜ 0.01
As a result show, model group Intestinal propulsive rate slows down compared with blank control group, residual rate and blank in model group stomach
Control group has statistical significance compared to increase, difference, illustrates modeling success.Each dosage group animal Intestinal propulsive rate increases, with
Model group is compared, and middle and high dosage group Intestinal propulsive rate difference has statistical significance.Residual rate declines in each dosage group animal stomach,
Compared with model control group, residual rate difference is statistically significant in middle and high dosage group stomach, illustrates that this pharmaceutical composition can promote
Small bowel peristalsis function and gastric emptying, contribute to digestion.
Two above experimental result shows that this pharmaceutical composition energy strengthening spleen and nourishing stomach promotes animal ingestion, promotes small bowel peristalsis
Function and gastric emptying, improve digestive function, increase the weight of animals.
2. adjust blood fat experiment
The preparation of high lipoprotein emulsion：High lipoprotein emulsion formula and ratio：Oil phase：Lard 25g, cholesterol 10g, Propylthiouracil Tablets
1g, Tween-80 25mL；Aqueous phase：Distilled water 30mL, 1,2-PD 20mL, NaTDC 2g.Specific preparation method：Oil phase：
Lard 25g is put into 200mL beaker, is heated to 100 DEG C, is added cholesterol 10g fusings, is added Propylthiouracil Tablets 1g,
Tween-80 25mL is added after fully mixing.Aqueous phase：Distilled water 30mL is added in 200mL beakers, 60 DEG C of water-bath water-baths, plus
Enter 1,2-PD 20mL, NaTDC 2g is fully dissolved, and aqueous phase then is added into oil phase, is sufficiently stirred for, and 4 DEG C are put after cooling
Refrigerator is saved backup.
SD rats (90~120 grams of body weight, SPF grades, male and female half and half) 60, male and female half and half.Adaptability is made after feeding one week
Mould.D0~D21 blank control group animal every mornings gavage physiological saline by 1mL/100g body weight doses, and modeling animal is per in the sky
Noon gavages fat emulsion by 1mL/100g body weight doses.D21 days to vein after normal group and nursing high lipid food group rat eye
Clump takes blood, determines total cholesterol level, and the selection successful animal of modeling is randomly divided into model control group, basic, normal, high dosage group.
10 rats separately are taken, male and female half and half are used as Normal group, not modeling.
D22~D49 blank control group every mornings gavage physiological saline, afternoon by 1mL/ by 1mL/100g body weight doses
100g body weight doses gavage physiological saline, and model control group, basic, normal, high dosage group every morning press 1.5mL/100g body weight agent
Amount gavages fat emulsion, and afternoon, model control group gavaged physiological saline, basic, normal, high dosage component by 1mL/100g body weight doses
Do not give 3g/kg, 6g/kg, 12g/kg this pharmaceutical composition, by 1mL/100g body weight gavages.Successive administration 4 weeks.In last 1 time
After administration, all animal fasting (can't help water) are stayed overnight.Rat blood sampling in second day, prepares serum, is grasped according to kit specification
Make the content that step surveys TC, TG, HDL-C, LDL-C absorbance and calculates each index.Liver weight is weighed, liver is calculated and refers to
Number, liver tissue homogenate detects hepatic tissue TC, TG absorbance and calculates each index and contains according to kit specification operating procedure
Amount.
TC, TG content (± SD) in the rat blood serum of table 4
*：Compared with model control group, P ＜ 0.05**：Compared with model control group, P ＜ 0.01
HDL-C, LDL-C content (± SD) in the rat blood serum of table 5
*：Compared with model control group, P ＜ 0.05**：Compared with model control group, P ＜ 0.01
TC, TG content and liver index (± SD) in the liver tissues of rats of table 6
*：Compared with model control group, P ＜ 0.05
As a result show, TC, TG, LDL-C content in high blood lipid model group rat blood serum substantially increase, and HDL-C contains
Amount substantially reduction, difference is statistically significant compared with normal rats, illustrates modeling success.In each dosage group animal blood serum
TC, TG, LDL-C content are reduced, HDL-C content increase, compared with model control group, middle and high dosage group serum TC, TG,
LDL-C, HDL-C content difference are statistically significant.Illustrate that the pharmaceutical composition can reduce TC, TG, LDL-C in animal blood serum and contain
Amount, increases HDL-C content.
TC in the homogenate of high blood lipid model group liver tissues of rats, TG contents substantially increase, the difference compared with normal rats
It is statistically significant.TC in each dosage group animal liver tissue homogenate, the reduction of TG contents, compared with model control group, middle and high dosage
TC in group liver tissue homogenate, TG content differences are statistically significant.The liver weight of high blood lipid model group substantially increases, and liver refers to
Number is compared with normal group, and there were significant differences.Each dosage group animal's liver index decreased, compared with model control group, high dose group liver
Dirty index differential is statistically significant, illustrates that high dose medicament composition can suppress liver weightening.
Above result of the test shows that animal is given after this pharmaceutical composition, in blood and liver under TC, TG, LDL-C content
Drop, HDL-C contents rise, and liver index declines.Illustrate that this pharmaceutical composition can adjust blood fat, have necessarily to anti-curing hyperlipemia
Effect.
In summary, this pharmaceutical composition can energy strengthening spleen and nourishing stomach, promotion animal ingestion, promotion small bowel peristalsis function and stomach row
Sky, improves digestive function, increases the weight of animals；TC, TG, LDL-C content in blood and liver can be promoted to decline, HDL-C contents
Rise, liver index declines.Illustrate that this pharmaceutical composition can adjust blood fat, have certain effect to anti-curing hyperlipemia.
Claims (10)
1. one kind has strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It is by following components and weight ratio
Composition：Melanoidin malt 8-100 parts by weight, red yeast rice 8-100 parts by weight, Semen Lablab Album 8-100 parts by weight, lotus leaf 8-100 parts by weight, Cassia
Sub- 8-100 parts by weight, the membrane of a chicken's gizzard 3-80 parts by weight, citron 3-80 parts by weight, charred FRUCTUS CRATAEGI 3-80 parts by weight.
2. it is according to claim 1 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It is burnt
Malt 10-80 parts by weight, red yeast rice 10-80 parts by weight, Semen Lablab Album 10-80 parts by weight, lotus leaf 10-80 parts by weight, cassia seed 10-80
Parts by weight, the membrane of a chicken's gizzard 5-60 parts by weight, citron 5-60 parts by weight, charred FRUCTUS CRATAEGI 5-60 parts by weight.
3. it is according to claim 1 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It is burnt
Malt 20-60 parts by weight, red yeast rice 20-60 parts by weight, Semen Lablab Album 20-60 parts by weight, lotus leaf 20-60 parts by weight, cassia seed 20-60
Parts by weight, the membrane of a chicken's gizzard 10-50 parts by weight, citron 10-50 parts by weight, charred FRUCTUS CRATAEGI 10-50 parts by weight.
4. it is according to claim 1 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It is burnt
Malt 30-50 parts by weight, red yeast rice 30-50 parts by weight, Semen Lablab Album 30-50 parts by weight, lotus leaf 30-50 parts by weight, cassia seed 30-50
Parts by weight, the membrane of a chicken's gizzard 15-40 parts by weight, citron 15-40 parts by weight, charred FRUCTUS CRATAEGI 15-40 parts by weight.
5. it is according to claim 1 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It is burnt
The parts by weight of malt 40, the parts by weight of red yeast rice 40, the parts by weight of Semen Lablab Album 40, the parts by weight of lotus leaf 40, the parts by weight of cassia seed 40, the membrane of a chicken's gizzard 20
Parts by weight, the parts by weight of citron 20, the parts by weight of charred FRUCTUS CRATAEGI 20.
6. it is according to claim 1 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It is burnt
The parts by weight of malt 15, the parts by weight of red yeast rice 15, the parts by weight of Semen Lablab Album 15, the parts by weight of lotus leaf 10, the parts by weight of cassia seed 15, the membrane of a chicken's gizzard 5
Parts by weight, the parts by weight of citron 6, the parts by weight of charred FRUCTUS CRATAEGI 5.
7. it is according to claim 1 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It
It is made up of following components and weight ratio：Fructus Hordei Germinatus extract 8-100 parts by weight, red yeast rice 8-100 extract weights part, Semen Lablab Album
Extract 8-100 parts by weight, Lotus Leafextract 8-100 parts by weight, cassia seed extract 8-100 parts by weight, Endothelium Corneum Gigeriae Galli extract
3-80 parts by weight, citron extract 3-80 parts by weight, Fructus Crataegi (parched to brown) extract 3-80 parts by weight.
8. it is according to claim 7 a kind of with strengthening spleen and nourishing stomach, help digestion and adjust the pharmaceutical composition of fat, it is characterised in that：It
It is made up of following components and weight ratio：The parts by weight of Fructus Hordei Germinatus extract 15, the extract weight part of red yeast rice 15, Semen Lablab Album extract
15 parts by weight, the parts by weight of Lotus Leafextract 10, the parts by weight of cassia seed extract 15, the parts by weight of Endothelium Corneum Gigeriae Galli extract 5, citron is extracted
The parts by weight of thing 6, the parts by weight of Fructus Crataegi (parched to brown) extract 5.
9. a kind of method for preparing the pharmaceutical composition in claim 1~8 described in any one claim, its feature exists
In：This method comprises the following steps：
S1：Melanoidin malt, red yeast rice, Semen Lablab Album, lotus leaf, cassia seed, the membrane of a chicken's gizzard, citron, charred FRUCTUS CRATAEGI are weighed by weight；
S2：Pharmaceutical composition is prepared into according to customary preparation methods.
10. a kind of method for preparing pharmaceutical composition according to claim 9, it is characterised in that：Described drug regimen
Thing is pulvis, granule, lotion, tablet, pill, powder, capsule, decoction, paste, effervescent agent.
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Application publication date: 20170929 |